WEBVTT - The young Aussies using Ozempic

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<v Speaker 1>This episode contains distressing themes, including suicide and disordered eating.

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<v Speaker 1>For twenty four to seven support, please contact Lifeline on

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<v Speaker 1>thirteen eleven fourteen. You'll find some links to more resources

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<v Speaker 1>in today's episode description.

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<v Speaker 2>Welcome to the eighty second Golden Gloves, Ozempik's biggest night.

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<v Speaker 1>Shall we think of this ozembic takeover in Hollywood?

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<v Speaker 3>Excuse me, Jennie, No, he's of ozembic.

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<v Speaker 1>From viral weight loss drug to Hollywood punchline.

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<v Speaker 4>What percent?

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<v Speaker 1>Shouldn't be the only ones whose body fat is one percent?

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<v Speaker 5>When I look.

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<v Speaker 6>Around the room, I can't help but wonder is ozembic

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<v Speaker 6>right for me?

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<v Speaker 1>Before ozempic took social media by storm, it was touted

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<v Speaker 1>as the miracle drug that could end type two diabetes.

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<v Speaker 1>Medications are changing the way that you think about diabetes

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<v Speaker 1>and weight management, but also cardiovascular risk management. Once lauded

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<v Speaker 1>as the silver bullet to the stars, Ozempic and other

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<v Speaker 1>similar medications slowly but surely crossed into the mainstream, bringing

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<v Speaker 1>with them new conversations about body image, ethics, health and accessibility.

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<v Speaker 7>There is so much demand. There is demand for this

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<v Speaker 7>that outstrips anything we ever say.

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<v Speaker 1>But what does the exploding global popularity of azenpic mean

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<v Speaker 1>for young.

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<v Speaker 6>People, the entire body neutrality movement has almost had this

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<v Speaker 6>regression where it's like, I don't know, we're actually back

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<v Speaker 6>to those sizes that we're trying to get away from,

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<v Speaker 6>and here's a drug that's going to fix everything.

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<v Speaker 1>Over the next three episodes, we'll explore the new world

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<v Speaker 1>of weight loss medication, its long term implications, the medical

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<v Speaker 1>and social ramifications of its growing popularity, and how it's

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<v Speaker 1>being prescribed and used in Australia Today.

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<v Speaker 4>Medicine and marketing should not be disconnected.

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<v Speaker 5>In this way, We'll.

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<v Speaker 1>Speak to experts, advocates and the people whose lives have

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<v Speaker 1>been changed by ozempic, for better or for worse.

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<v Speaker 3>From the daily os.

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<v Speaker 1>I'm Emma Gillespie and this is investigating Ozempic Part one.

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<v Speaker 1>Ozempic was first approved by health authorities in the US

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<v Speaker 1>in twenty seventeen as a medication to treat type two diabetes,

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<v Speaker 1>approved for use in Australia the following year. The drug

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<v Speaker 1>now generates billions of dollars annually for its manufacturer, Novo Nordisk,

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<v Speaker 1>which has become one of the world's richest pharmaceutical companies.

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<v Speaker 1>But what is ozempic and how does it actually work.

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<v Speaker 7>So, Zempic's a drug name, and it's a drug name

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<v Speaker 7>for what is otherwise known as semaglue tide. Semaglue tide

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<v Speaker 7>falls into this family of drugs called glp ones.

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<v Speaker 3>That's doctor Michael Bonding.

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<v Speaker 1>He is the Australian Medical Association Chair of Public Health

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<v Speaker 1>and Sydney GP.

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<v Speaker 7>Ozempic is the one that has been talked about so

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<v Speaker 7>much in the media, but actually there are two others

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<v Speaker 7>that get a lot of coverage as well. One is

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<v Speaker 7>called weigov which is just a higher dose version of ozempic,

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<v Speaker 7>and another one that is called Munjaro. They act on

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<v Speaker 7>hormones in our body and generally they were developed for

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<v Speaker 7>diabetes patients. What they did for them was making sure

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<v Speaker 7>that the cells work better with insulin, but also then

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<v Speaker 7>that gastric emptying is slowed down so you feel fuller faster.

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<v Speaker 7>You ended up with people losing significant amounts of weight,

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<v Speaker 7>which for many people with diabetes is also a significant

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<v Speaker 7>benefit to improving their diabetic control. But for those who

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<v Speaker 7>don't have diabetes, that side effect has meant that these

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<v Speaker 7>drugs have become increasingly popular for an indication that they

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<v Speaker 7>weren't originally put on the market for.

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<v Speaker 8>With those Zampig's popularity for dramatic weight loss, it's been

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<v Speaker 8>hard to get. But a new similar drug has the

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<v Speaker 8>same active ingredient as ozempig.

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<v Speaker 2>Wheregovi helped people lose on average fifteen percent of their

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<v Speaker 2>body weight, that's compared with the nearly twenty three percent

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<v Speaker 2>achieved by Maunjaro. The battle of the weight loss drugs continues.

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<v Speaker 1>Taken as an injection, usually once a week, doctor Bonning says,

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<v Speaker 1>ozempic and other GLP one medications start working almost immediately,

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<v Speaker 1>within a few hours. For twenty six year old Grace,

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<v Speaker 1>the overall experience of weight loss medication gave her a

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<v Speaker 1>confidence that she had never felt before. Grace wrote to

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<v Speaker 1>us from Brisbane to tell us about her experience. Here's

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<v Speaker 1>a bit of her story, voiced by someone else.

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<v Speaker 8>My entire life, I have been slightly overweight since becoming

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<v Speaker 8>an adult, working an office job, no longer doing sports,

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<v Speaker 8>the weight started to climb slightly. It wasn't until I

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<v Speaker 8>moved away from home and experienced a really rough time

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<v Speaker 8>that I ended up putting on significant weight in a

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<v Speaker 8>short period. This was the start of a number of

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<v Speaker 8>health problems for me. I had kidney stones, I had gallstones.

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<v Speaker 8>I was generally unhappy and lacking a lot of self love.

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<v Speaker 1>Grace has used both ozenpic and Munjaro at different times

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<v Speaker 1>since June twenty twenty three.

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<v Speaker 8>Munjaro was significantly more expensive, but it gave me almost

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<v Speaker 8>no side effects. Because of that, I was able to

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<v Speaker 8>consistently stay on the medication for about six months.

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<v Speaker 1>She lost over seventeen kilos during that time, and since then,

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<v Speaker 1>Grace says her life has changed. Her confidence has transformed.

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<v Speaker 1>The joined pain she used to feel daily has disappeared.

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<v Speaker 8>I'm not embarrassed to walk up the stairs with someone.

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<v Speaker 8>I feel confident that I could physically get myself out

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<v Speaker 8>of danger if I had to. The mobility is insane.

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<v Speaker 8>The change of perspective is enormous.

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<v Speaker 1>Grace said she feels in control of her food choices

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<v Speaker 1>for the first time in her life. She details experiencing

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<v Speaker 1>a shift in how she thinks about food, what Grace

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<v Speaker 1>describes as previous compulsions and food noise all day, every day.

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<v Speaker 1>She told us it's a difficult thing to explain to

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<v Speaker 1>someone who's never experienced issues with food noise, but Grace

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<v Speaker 1>likens it to listening to a loud song on repeat,

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<v Speaker 1>and you've got no ability to change the song, or

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<v Speaker 1>turn down the volume or take a break. For her,

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<v Speaker 1>both glp won medications, Ozempic and Munjaro.

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<v Speaker 3>Were like finally someone.

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<v Speaker 1>Had given her a remote to listen to something else.

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<v Speaker 8>It was so healing to know that I wasn't just

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<v Speaker 8>worse than skinny people, or I wasn't just weak. My

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<v Speaker 8>brain wasn't working against me anymore.

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<v Speaker 1>Grace's story is just one of the hundreds of positive

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<v Speaker 1>anecdotes we received when we asked our audience about their

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<v Speaker 1>experiences using Ozenpic and similar medications. Dozens of TDA followers

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<v Speaker 1>told us that these drugs have changed their life, that

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<v Speaker 1>they've never been happier or healthier. Some of you told

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<v Speaker 1>us it's saved your life. We could go on for

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<v Speaker 1>hours talking through all the many glowing reviews we received

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<v Speaker 1>about Ozeenpic, Munjaro, and we go v.

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<v Speaker 3>But while so many of you.

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<v Speaker 1>Did have a positive experience with these medications, hundreds of

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<v Speaker 1>you also told us the exact opposite. Several TDA followers

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<v Speaker 1>told us they've ended up in hospital after taking ozenpic,

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<v Speaker 1>with gallbladder removal being the most commonly reported issue.

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<v Speaker 7>As with most drugs, most side effects are dose dependent.

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<v Speaker 7>They often are worse at higher doses.

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<v Speaker 1>We'll be back with more of today's episode right after this. Ultimately,

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<v Speaker 1>GLP one medications like ozeenpic are still relatively new, and

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<v Speaker 1>that means the full list of side effects associated with

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<v Speaker 1>their long term use remains somewhat unknown. GPS and healthcare

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<v Speaker 1>providers can report adverse side effects relating to these medications

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<v Speaker 1>to the federal government's Department of Health. These reports are

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<v Speaker 1>tracked on the Therapeutic Goods Administration's Database of Adverse Event Notifications.

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<v Speaker 1>The online tracker includes negative symptoms associated with the use

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<v Speaker 1>of any medication, but you can filter down by type.

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<v Speaker 3>So that's what we did. To look at ozepic.

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<v Speaker 1>Wegov and compounded products or pharmacy made versions of these drugs,

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<v Speaker 1>as well as semagluetide products where the brand name was

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<v Speaker 1>not specified. Remembering that semaglutides are a type of GLP one.

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<v Speaker 1>GLP ones are these weight loss medications that we are

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<v Speaker 1>talking about. On the database, gastro Intestinal disorders, including pancreatitis,

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<v Speaker 1>made up around half of the adverse events reported between

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<v Speaker 1>January twenty twenty three and January twenty twenty five. But

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<v Speaker 1>there's another particularly sinister side effect associated with ozempic use

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<v Speaker 1>that's becoming increasingly prominent. I, for no reason whatsoever, and

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<v Speaker 1>I hadn't felt like this for a very long time,

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<v Speaker 1>became suicidal unable to work.

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<v Speaker 5>It was really quite unexplained.

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<v Speaker 1>Mackenzie is a twenty six year old woman who sought

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<v Speaker 1>out a zenpic for weight management.

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<v Speaker 5>I've tried diet exercise and haven't been able to get

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<v Speaker 5>that to work for the long term.

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<v Speaker 1>But taking ozepic would lead her down one of the

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<v Speaker 1>most frightening periods of her life.

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<v Speaker 5>I was really really concerned, and I chatted with my

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<v Speaker 5>partner about it, and he was like, well, the only

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<v Speaker 5>thing that has changed in your life is you going

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<v Speaker 5>on this particular medication.

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<v Speaker 1>Suicidal ideation makes up one in every twenty adverse GLP

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<v Speaker 1>one reactions reported to the TGA database. Since January twenty

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<v Speaker 1>twenty three, there have been three reports of attempted suicide

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<v Speaker 1>and separately, two deaths by suicide associated with the use

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<v Speaker 1>of these medications. Ozepic was the only product suspected to

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<v Speaker 1>be related to both of those deaths. The TGA website

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<v Speaker 1>stresses that the reports included in the database doesn't mean

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<v Speaker 1>the details of the event have been confirmed or that

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<v Speaker 1>the event has been determined to be related to that

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<v Speaker 1>specific medication that it's listed alongside. The TGA says it

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<v Speaker 1>uses adverse event reports to quote identify when a safety

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<v Speaker 1>issue may be present, but it says assessing the safety

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<v Speaker 1>of a medication cannot be made using the tracker alone.

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<v Speaker 5>Saw Juniper advertised and decided to go through the questionnaire

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<v Speaker 5>that they've got online, put in all accurate information, and

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<v Speaker 5>it gave me a prescription for ozenpic.

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<v Speaker 1>Juniper is one of a growing number of online platforms

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<v Speaker 1>that privately prescribe weight loss medications without requiring face to

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<v Speaker 1>face consults. It's a virtual or telehealth service, and while

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<v Speaker 1>individual practitioners must comply with compulsory standards, there is no

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<v Speaker 1>current mandatory safety and quality standards framework for these platforms.

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<v Speaker 1>Mackenzie disclosed to but that she'd been taking antidepressants since

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<v Speaker 1>her early teens before she received a prescription for ozenpic.

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<v Speaker 5>So I started receiving that in the mail and injecting

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<v Speaker 5>that as per kind of the recommended guidelines. I kind

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<v Speaker 5>of had peace of mind that it would cover everything

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<v Speaker 5>that was in my medical history.

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<v Speaker 1>Mackenzie started on what she said was quite a low

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<v Speaker 1>dose of ozempic, but a month later she ramped up

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<v Speaker 1>to a higher dose, and that's when she says things

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<v Speaker 1>started feeling off, essentially out of nowhere. She describes experiencing

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<v Speaker 1>suicidal ideations. Mackenzie shared her concerns with her regular GP,

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<v Speaker 1>but that GP is not the person who prescribed her

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<v Speaker 1>this medication. She got the drugs through Juniper.

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<v Speaker 5>He said that he'd seen this in a number of patients.

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<v Speaker 5>He explained to me how it kind of worked, and

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<v Speaker 5>one of the things is that it slows the digestive system,

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<v Speaker 5>which then can have negative effects on absorption.

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<v Speaker 1>The medication Mackenzie was taking had stopped her body from

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<v Speaker 1>absorbing the antidepressants that she'd been used to taking for

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<v Speaker 1>more than a decade.

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<v Speaker 5>I was in such a bad place that he suggested

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<v Speaker 5>I go to hospital, stop taking it and contact Gina

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<v Speaker 5>pet to let them know that I was no longer

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<v Speaker 5>taking it and explain what the side effects of that

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<v Speaker 5>had been for me.

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<v Speaker 1>Mackenzie followed the advice of her regular GP and stopped

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<v Speaker 1>taking ozebic immediately, but due to the slow release nature

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<v Speaker 1>of the drug, it took over a month for her

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<v Speaker 1>to start feeling like herself again. The twenty six year

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<v Speaker 1>old said she was surrounded by the right people and

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<v Speaker 1>the right support to get herself back to feeling safe

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<v Speaker 1>and happy. She considers herself one of the lucky ones,

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<v Speaker 1>but Mackenzie holds broader concerns about what these prescribing practices

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<v Speaker 1>could mean that at risk young people.

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<v Speaker 5>The fact that this is so freely available without even

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<v Speaker 5>so much as a zoom call or a face to

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<v Speaker 5>face check in is really really concerning to me, and

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<v Speaker 5>I think something needs to be done regarding the access

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<v Speaker 5>people have to this medication. I'm not saying that we

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<v Speaker 5>should never use it and that it should be totally

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<v Speaker 5>out of the question, but I think some kind of

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<v Speaker 5>regulation needs to be put in place.

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<v Speaker 1>So how are these medications regulated and how many people

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<v Speaker 1>are taking them in Australia.

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<v Speaker 3>The short answer to the second part of.

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<v Speaker 1>That question is really we have no idea, and that's

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<v Speaker 1>because of the way that these drugs are classified by

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<v Speaker 1>health regulators and something called the Pharmaceutical Benefit Scheme, The PBS.

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<v Speaker 7>Ozepic is funded by the Australian government, so on the

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<v Speaker 7>PBS for those people who meet certain parameters around their

0:13:34.920 --> 0:13:38.720
<v Speaker 7>type two diabetes, so those people need to be the

0:13:38.760 --> 0:13:40.840
<v Speaker 7>ones who are prioritized to get access to it.

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<v Speaker 3>Let's break that down.

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<v Speaker 1>Ozepic is a PBIS listed drug for type two diabetes treatment,

0:13:46.640 --> 0:13:50.040
<v Speaker 1>so because of that, it'll cost a diabetic around forty

0:13:50.080 --> 0:13:53.120
<v Speaker 1>dollars a month to access. That doesn't mean it's illegal

0:13:53.200 --> 0:13:55.880
<v Speaker 1>to use ozepic for other reasons, but it does mean

0:13:55.960 --> 0:13:59.880
<v Speaker 1>prescriptions issued for a purpose other than diabetes, what's called

0:14:00.080 --> 0:14:04.360
<v Speaker 1>off label uses, aren't subsidized by the PBS and therefore

0:14:04.600 --> 0:14:08.600
<v Speaker 1>aren't tracked by it either. These private scripts also cost

0:14:08.640 --> 0:14:11.520
<v Speaker 1>patients upwards of four hundred dollars a month.

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<v Speaker 7>The other two medications are not on the PBS for

0:14:16.360 --> 0:14:17.040
<v Speaker 7>that indication.

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<v Speaker 1>Doctor Michael Bonning is talking about Munjaro and we go

0:14:20.480 --> 0:14:23.560
<v Speaker 1>v but we gov could soon become cheaper for some

0:14:23.640 --> 0:14:26.680
<v Speaker 1>people who take it after the TGA recently approved this

0:14:26.840 --> 0:14:30.200
<v Speaker 1>drug as a treatment for heart disease in overweight patients.

0:14:30.880 --> 0:14:34.360
<v Speaker 1>This means the Medicine regulator has determined there is satisfactory

0:14:34.360 --> 0:14:37.880
<v Speaker 1>evidence that we govy is an effective complementary therapy for

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<v Speaker 1>adults with both cardiovascular disease and high body mass index

0:14:42.480 --> 0:14:46.040
<v Speaker 1>to reduce the related risk of heart attack, stroke or death.

0:14:46.560 --> 0:14:49.120
<v Speaker 1>We can find out how many people take ozenpic for

0:14:49.200 --> 0:14:51.840
<v Speaker 1>type two diabetes treatment, and we might soon be able

0:14:51.880 --> 0:14:54.000
<v Speaker 1>to find out how many people take we go v

0:14:54.040 --> 0:14:57.240
<v Speaker 1>as a treatment for heart disease, But for everything else

0:14:57.720 --> 0:15:01.160
<v Speaker 1>it's virtually impossible to determine and the scale of the

0:15:01.280 --> 0:15:05.600
<v Speaker 1>use of these medications. Doctor Emma Beckett, a food and

0:15:05.720 --> 0:15:09.560
<v Speaker 1>nutrition scientist and an adjunct Senior lecturer at UNSW, says

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<v Speaker 1>this is an issue that needs to shift urgently.

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<v Speaker 4>My suspicion is the vast number of people accessing these

0:15:17.640 --> 0:15:23.400
<v Speaker 4>medications in Australia are accessing them through telehealth and not

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<v Speaker 4>through their standard GP. And for me, the question is

0:15:27.600 --> 0:15:30.120
<v Speaker 4>why are they going to their standard GP, and their

0:15:30.160 --> 0:15:32.720
<v Speaker 4>standard GP is going no, no, you don't need that,

0:15:33.320 --> 0:15:34.920
<v Speaker 4>and you go to the people who are selling them

0:15:34.920 --> 0:15:37.400
<v Speaker 4>directly and that's their purpose and they go, well, of

0:15:37.480 --> 0:15:41.280
<v Speaker 4>course you can have that. And so my question is

0:15:41.320 --> 0:15:44.000
<v Speaker 4>about how do we look at that context because I

0:15:44.000 --> 0:15:46.520
<v Speaker 4>don't think we have that data.

0:15:46.840 --> 0:15:50.400
<v Speaker 1>So without that database of prescriptions, we decided to look

0:15:50.400 --> 0:15:53.120
<v Speaker 1>into this further to get a sense of how young

0:15:53.160 --> 0:15:58.080
<v Speaker 1>people are engaging with these medications. Around twenty five thousand

0:15:58.080 --> 0:16:00.760
<v Speaker 1>of you responded to a poll by The Daily Ods.

0:16:01.360 --> 0:16:04.560
<v Speaker 1>Eleven percent told us they had used Ozenpic or a

0:16:04.600 --> 0:16:07.920
<v Speaker 1>similar drug. We asked the eighty nine percent who hadn't

0:16:07.960 --> 0:16:11.680
<v Speaker 1>used it if they've ever wanted to try ozenpic. Forty

0:16:11.720 --> 0:16:17.400
<v Speaker 1>three percent of respondents said yes. We heard from nurses, surgeons,

0:16:17.480 --> 0:16:21.280
<v Speaker 1>GP and other health professionals who said GLP one medications

0:16:21.480 --> 0:16:25.520
<v Speaker 1>licosenpic are among the most prescribed drugs in the country,

0:16:26.360 --> 0:16:29.200
<v Speaker 1>but it's how people are accessing these drugs, or rather

0:16:29.560 --> 0:16:33.840
<v Speaker 1>where they're getting their prescriptions that has some experts concerned.

0:16:34.240 --> 0:16:38.560
<v Speaker 4>If you Google interested in these drugs, the top hits

0:16:38.720 --> 0:16:43.000
<v Speaker 4>are not results to studies, They're not informational pieces. They're

0:16:43.000 --> 0:16:47.520
<v Speaker 4>links to the companies who are selling it, and medicine

0:16:48.080 --> 0:16:53.720
<v Speaker 4>and marketing should not be disconnected in this way because

0:16:53.960 --> 0:16:58.920
<v Speaker 4>I can't think of any other medication that happens like this.

0:17:03.240 --> 0:17:08.239
<v Speaker 1>On the next episode of Investigating Ozenpic, we take a

0:17:08.320 --> 0:17:11.840
<v Speaker 1>closer look at the online providers prescribing weight loss medication

0:17:12.040 --> 0:17:15.320
<v Speaker 1>in Australia. We'll look into their duty of care and

0:17:15.400 --> 0:17:19.400
<v Speaker 1>whether or not they're meeting those responsibilities. We'll hear from

0:17:19.560 --> 0:17:23.360
<v Speaker 1>the people who've accessed these drugs through these providers and

0:17:23.720 --> 0:17:25.120
<v Speaker 1>those who've worked for them.

0:17:25.480 --> 0:17:28.800
<v Speaker 4>If these people started these companies to deliberately sell these

0:17:28.800 --> 0:17:32.119
<v Speaker 4>weight loss drugs, that says there's a gap. That says

0:17:32.160 --> 0:17:34.159
<v Speaker 4>when people are going to the doctor and having this

0:17:34.200 --> 0:17:38.680
<v Speaker 4>conversation with their regular GP, they're not getting what they need.

0:17:39.200 --> 0:17:42.200
<v Speaker 1>We'll answer all your questions and more on part two.

0:17:43.600 --> 0:17:47.400
<v Speaker 1>Thank you so much for listening to this episode. If

0:17:47.400 --> 0:17:51.040
<v Speaker 1>it's raised any concerns for you, help is available twenty

0:17:51.080 --> 0:17:54.760
<v Speaker 1>four to seven through lifelined on thirteen eleven fourteen. For

0:17:54.840 --> 0:17:58.080
<v Speaker 1>eating disorder support, you can contact the Butterfly Foundation on

0:17:58.080 --> 0:18:01.400
<v Speaker 1>one eight hundred eighty hope. That's one eight hundred three

0:18:01.480 --> 0:18:05.520
<v Speaker 1>three four six seventy three. There are also some links

0:18:05.560 --> 0:18:08.240
<v Speaker 1>to resources in today's episode description.

0:18:13.200 --> 0:18:15.520
<v Speaker 3>My name is Lily Maddon and I'm a proud Arunda

0:18:15.720 --> 0:18:18.280
<v Speaker 3>Bunjelung Calcuttin woman from Gadighl Country.

0:18:19.119 --> 0:18:22.280
<v Speaker 8>The Daily oz acknowledges that this podcast is recorded on

0:18:22.320 --> 0:18:24.800
<v Speaker 8>the lands of the Gadighl people and pays respect to

0:18:24.880 --> 0:18:28.200
<v Speaker 8>all Aboriginal and torrest Rate Island and nations. We pay

0:18:28.200 --> 0:18:31.120
<v Speaker 8>our respects to the first peoples of these countries, both

0:18:31.200 --> 0:18:32.080
<v Speaker 8>past and present.