WEBVTT - From the Vault: Eternal Youth, Part 1

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<v Speaker 1>Hey, are you welcome to stuff to blow your mind?

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<v Speaker 1>My name is Robert Lamb and I'm Joe McCormick, and

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<v Speaker 1>it's Saturday. Time to venture into the vault, this time

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<v Speaker 1>with an episode about youth and aging. This is Eternal Youth,

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<v Speaker 1>Part one, originally published January four. This is one of

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<v Speaker 1>the episodes. I think we did a pair here where

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<v Speaker 1>we were sort of asking the question why animals age? Why?

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<v Speaker 1>Why why not just stay young? Forever? Yeah? Youth like

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<v Speaker 1>diamonds in the sun, right, um, forever young Alphaville. Hopefully

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<v Speaker 1>I don't remember if I referenced that track uh in

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<v Speaker 1>these episodes, but I hope I did. I think you

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<v Speaker 1>referenced it more recently when pointing out how creepy the

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<v Speaker 1>lyrics are that they they sound like a serial killer. Note, yeah,

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<v Speaker 1>they're they're they're super creepy. That track is the reason

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<v Speaker 1>I didn't share my You know a lot of people

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<v Speaker 1>are sharing, uh, these curated lists of what tracks they

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<v Speaker 1>listened to the most in the previous year. That was

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<v Speaker 1>your number one? It was, it was, it was, it

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<v Speaker 1>was up there way too much, and I have to

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<v Speaker 1>I can only share that with people if I can

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<v Speaker 1>also explain to them that I have a very creepy

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<v Speaker 1>interpretation of the song and therefore me listening to Forever

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<v Speaker 1>Young is like most people listening to death metal. I'm

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<v Speaker 1>gonna see you and raise you there because the other

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<v Speaker 1>Forever Young also has creepy lyrics if you listen to them.

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<v Speaker 1>Oh yeah, this is the Bob Dylan r. Yeah yeah yeah,

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<v Speaker 1>just go listen, you'll you'll see. All right, Well, let's

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<v Speaker 1>jump right into it. Welcome to Stuff to Blow your

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<v Speaker 1>Mind from how stuff dot com. Hey you, welcome to

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<v Speaker 1>Stuff to Blow your Mind. My name is Robert Lamb

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<v Speaker 1>and I'm Joe McCormick and Robert, I want to ask

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<v Speaker 1>you about a Greek commit go for it. You know,

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<v Speaker 1>the myth of tiffan Us. This is not one that

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<v Speaker 1>I am am readily familiar with off stuff of my head. Well,

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<v Speaker 1>it's one of those great ones with doomed lovers. Are

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<v Speaker 1>doomed lovers? Just fantastic? Yea? Is there? Does a god

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<v Speaker 1>show up the act particularly crappy towards mortals? Uh not.

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<v Speaker 1>I don't know if it's on purpose. You do get

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<v Speaker 1>Zeus being a jerk, but he might be like he's

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<v Speaker 1>a jerk by accident. Or maybe he's a jerk on purpose.

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<v Speaker 1>It's kind of hard to tell, because being a jerk

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<v Speaker 1>is kind of Zeus is default thing in general. Yeah,

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<v Speaker 1>Zeus in this myth acts kind of like the Monkeys

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<v Speaker 1>Paul and the classic short story, where you get the

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<v Speaker 1>wish but not quite in the way you wanted it.

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<v Speaker 1>So here's how it goes. And this is the version

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<v Speaker 1>that's in the Homeric Hymn to Aphrodite. So the myth

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<v Speaker 1>involves the goddess aos Aus is the goddess of Dawn,

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<v Speaker 1>and she falls in love with a mortal man from

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<v Speaker 1>Troy named tiffan Us. And this is horrible, right, It's

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<v Speaker 1>horrible for a goddess to fall in love with a

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<v Speaker 1>mortal because while the gods may live eternally, dining on

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<v Speaker 1>the ambrosia and just going on into the future, of course,

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<v Speaker 1>mortal people, as the name implies, will die. And she

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<v Speaker 1>hates this idea. She hates the idea that the man

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<v Speaker 1>she's fallen in love with will someday die while she

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<v Speaker 1>gets to go on living forever. She can't bear the

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<v Speaker 1>thought of it. So she goes to Zeus and she

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<v Speaker 1>makes a request, Well, you grant my lover Tiffanus eternal life,

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<v Speaker 1>and Zeus does it. Usually, you know, usually Zeus is

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<v Speaker 1>a jerk, but here he's like, yes, yes, I will

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<v Speaker 1>do that for you. Aos. Well, maybe he was busy

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<v Speaker 1>and he's just like, okay, yeah, I'm just go ahead

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<v Speaker 1>check this off the list because I've I've got this, uh,

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<v Speaker 1>this other torment in mind for another mortal. Right, don't

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<v Speaker 1>have time to be a jerk. Just bam, eternal life.

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<v Speaker 1>You will not perish and die like the other mortals.

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<v Speaker 1>But then it takes a dark turn. So let me

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<v Speaker 1>read from the translation of the Home Eric him to Aphrodite,

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<v Speaker 1>and this is translated by Hugh Evelyn White. Quote. So

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<v Speaker 1>also golden throned Aos wrapped away Tiffanus, who was of

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<v Speaker 1>your race and like the deathless gods. And she went

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<v Speaker 1>to ask the dark clouded son of ChRI On knows

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<v Speaker 1>that he should be deathless and live eternally. And Zeus

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<v Speaker 1>bowed his head to her prayer and fulfilled her desire. Okay,

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<v Speaker 1>so he's granning the wish. Too simple, was queenly Aos.

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<v Speaker 1>She thought not in her heart to ask youth for

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<v Speaker 1>him and to strip him of the slough of deadly age.

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<v Speaker 1>So while he enjoyed the sweet flower of life, he

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<v Speaker 1>lived rapturously with golden throned Aos, the early born by

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<v Speaker 1>the streams of ocean at the ends of the earth.

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<v Speaker 1>But when the first gray hairs began to ripple from

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<v Speaker 1>his comely head and noble chin, queenly Aos kept away

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<v Speaker 1>from his bed, though she cherished him in her house,

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<v Speaker 1>and nourished him with food and ambrosia, and gave him

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<v Speaker 1>rich clothing. But when loathsome old age pressed full upon him,

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<v Speaker 1>and he could not move nor lift his limbs. This

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<v Speaker 1>seemed to her in her heart the best counsel. She

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<v Speaker 1>laid him in a room and put to the shining doors.

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<v Speaker 1>There he babbles endlessly, and no more has strength at all,

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<v Speaker 1>such as once he had in his supple limbs. M Okay, well,

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<v Speaker 1>this makes me think Zeus probably just agreed to her request,

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<v Speaker 1>because all the gods know that mortals are going to

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<v Speaker 1>ask for immortality at some point or the other, and

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<v Speaker 1>they're probably not going to phrase the question properly, and

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<v Speaker 1>you should let them have it because it will teach

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<v Speaker 1>them a lesson. Well, yeah, he'll learn when he's old

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<v Speaker 1>and babbling and decrepit. But cannot die. Yeah, because global

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<v Speaker 1>myth cycles are filled with stories of of immortality gone wrong.

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<v Speaker 1>You know, it's either a wandering immortal who's doomed or

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<v Speaker 1>or lovers who you know, obtain a portion of immortality

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<v Speaker 1>and it's mishandled. There's a there's a wonderful example of

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<v Speaker 1>this in in Chinese myth with the the Elixir of

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<v Speaker 1>Immortality and the and the Woman of the Moon. Oh

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<v Speaker 1>does it come back to bite her? Or come back

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<v Speaker 1>to bite the person who wants it? Um it gets

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<v Speaker 1>There are a few different versions of the tale, but essentially,

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<v Speaker 1>you know, one person is immortal and the other is not.

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<v Speaker 1>That sort of thing, this this this mismatch that we

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<v Speaker 1>see president in the Greek tale as well. Man, why

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<v Speaker 1>are there so many myths and folk tales where people

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<v Speaker 1>get punished for wanting better than their lot in life? Well,

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<v Speaker 1>because you can't have it, I mean, especially when it

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<v Speaker 1>comes to things like avoiding death and avoiding aging. You're

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<v Speaker 1>not gonna get it. So there's something refreshing about stories

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<v Speaker 1>in which people do get it and it backfires because

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<v Speaker 1>that way we think, oh, well, this this thing that

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<v Speaker 1>I cannot have is actually not that great. So thank goodness,

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<v Speaker 1>I'm going to grow old and die. Yeah. I wonder

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<v Speaker 1>if it makes you feel like you're not so bad off.

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<v Speaker 1>It's like, well, I'm gonna die one day, but I

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<v Speaker 1>could be like Tiffanous, and that's even worse. Exactly, So,

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<v Speaker 1>I think the myth is sort of an embodiment of

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<v Speaker 1>this cruel fact about human nature. It's not just that,

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<v Speaker 1>as they say in Bravos, all men must die, but

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<v Speaker 1>that all people must decline. I think warrensy On put

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<v Speaker 1>it best. He said time treats everybody like a fool.

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<v Speaker 1>And I think that's the case. And no amount of lawyers, guns,

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<v Speaker 1>or money will get you out of this, that's right.

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<v Speaker 1>So on one hand, you've got the idea of death.

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<v Speaker 1>And death is a sort of unavoidable fact about biology

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<v Speaker 1>because living organisms are these finely tuned factories of chemical reactions,

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<v Speaker 1>and if you make substantial changes to the factory, say

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<v Speaker 1>by jamming a rock through part of it, or biting

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<v Speaker 1>part of it off, or filling it up with parasites

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<v Speaker 1>that gum up all the gears, the factory isn't going

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<v Speaker 1>to work the same anymore. It might not work at all.

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<v Speaker 1>Were physical creatures were subject to physical disruption. So the

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<v Speaker 1>potential for death is unavoidable. It's sort of part of

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<v Speaker 1>what it means to be alive. But aging not quite

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<v Speaker 1>so much. This steady time correlated decline in our biological fitness.

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<v Speaker 1>Why does that have to happen? That's not physically inevitable

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<v Speaker 1>in same way that death is. Yes, and this is

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<v Speaker 1>going to be the question we're gonna be discussing in

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<v Speaker 1>this pair of episodes. Now, we do want to drive home.

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<v Speaker 1>We're not going to get as much into some of

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<v Speaker 1>the mechanics of aging, like we're not going to get

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<v Speaker 1>into telomeres and telomerase and all and all of that,

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<v Speaker 1>although that's a wonderfully insightful topic onto itself. We're gonna

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<v Speaker 1>be talking more about the these this sort of evolutionary

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<v Speaker 1>function of aging, if it has one, right, aging is

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<v Speaker 1>something that has such a cost for the organisms that

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<v Speaker 1>undergo it, like tiffanus. What pays for it biologically? Why

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<v Speaker 1>does it exist? Now, to underscore the fact that aging

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<v Speaker 1>is not necessarily something that is inevitable, and especially not

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<v Speaker 1>aging as early as we do, we should maybe look

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<v Speaker 1>at some organisms that do not age in the same

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<v Speaker 1>way we do. Yeah, they're there are a number of organisms.

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<v Speaker 1>I'm sure a number of them come to to everyone's

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<v Speaker 1>mind here. You think of ancient hoary tortoise is stumbling

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<v Speaker 1>across the the ground, right, or perhaps your mind turns

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<v Speaker 1>with the greenland shark. Will come back to that one

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<v Speaker 1>in a second. But really one of the more insightful

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<v Speaker 1>examples here is the hydra, or at least individuals in

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<v Speaker 1>the Hydra genus. So you're talking about the monster that

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<v Speaker 1>gets its head cut off and grows two more. No,

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<v Speaker 1>as much as I do love the mythical hydra, now

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<v Speaker 1>these are the natural world. Hydra's tiny tentacled creatures that

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<v Speaker 1>need to continue to wow scientists because they have a

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<v Speaker 1>number of just wonderfully bizarre and monstrous capability. So they

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<v Speaker 1>can reproduce through a sexual butting. They have these mouths

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<v Speaker 1>that open up kind of like wounds in their body

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<v Speaker 1>and then close. There's some fabulous videos of them doing that.

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<v Speaker 1>It looks like you're staring into the mouth of hell.

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<v Speaker 1>And they have this seemingly natural inability to grow, grow old,

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<v Speaker 1>and die of natural causes. They boast low mortality rates

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<v Speaker 1>throughout their lives, and apparently this is according to when

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<v Speaker 1>Dr Owen Jones from the University of Southern Denmark. He

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<v Speaker 1>has claimed that it would take four hundred years for

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<v Speaker 1>of a hydro population to die of natural causes in

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<v Speaker 1>the lab. Wow, well, well that's a hardy species. Yeah,

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<v Speaker 1>So let me let me back some of that up

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<v Speaker 1>here with with some more the facts about the life

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<v Speaker 1>of the hydra, so their fertility rates remain constant their

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<v Speaker 1>entire lives, which, as will discuss is is pretty unique.

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<v Speaker 1>And according to Pomono College biology researcher Professor Daniel Martinez,

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<v Speaker 1>he has repeatedly found no evidence of sinescence in laboratory

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<v Speaker 1>caddled hydra. Yeah, and even goes so far as to

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<v Speaker 1>state that an individual hydra can live forever under the

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<v Speaker 1>right laboratory circumstances. Now, of course, that's the catch, right.

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<v Speaker 1>The hydro's natural environment offers sufficient hostilities to make natural

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<v Speaker 1>death by old age and impossibility. You got disease, predators,

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<v Speaker 1>water contamination. These are the things that usually all a

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<v Speaker 1>hydra off in due time, and likewise, scientists have yet

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<v Speaker 1>to create a hydra utopia that can sustain them indefinitely. Now,

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<v Speaker 1>this is a good point in the use of the

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<v Speaker 1>word immortality, which sometimes comes up when people are covering

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<v Speaker 1>organisms like these. There are a couple of different ways

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<v Speaker 1>you could look at immortality. One would be the Highlander

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<v Speaker 1>version or something like that, where there's just like nothing

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<v Speaker 1>that can kill you except maybe one or two little things,

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<v Speaker 1>but that you are generally invulnerable to death. And then

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<v Speaker 1>there'd be a different version of immortality that says, yeah,

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<v Speaker 1>you're vulnerable to death by injury or disease, you just

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<v Speaker 1>don't naturally grow old and die. You don't have a

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<v Speaker 1>cap on your life span. That would be more like

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<v Speaker 1>what are the elves of Middle Earth? Kind of like that,

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<v Speaker 1>Like they can be killed in battle, but they don't

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<v Speaker 1>grow old and die. Yeah. Well, I mean I would

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<v Speaker 1>argue that the immortals of Highlander are much the same,

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<v Speaker 1>Like there's a there's a very specific thing you can

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<v Speaker 1>do to kill them, uh, and technically anyone can do it.

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<v Speaker 1>It's just you've got to get the drop on a right.

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<v Speaker 1>We should mention that we're popping in little references to

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<v Speaker 1>Highlander to get you ready for the fact that one

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<v Speaker 1>day soon we're going to do a Science of Highlander

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<v Speaker 1>two episode and I'm not kidding. Yeah, you have advanced

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<v Speaker 1>warning so you can all go review at least the

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<v Speaker 1>first two films. Well, I would say just the first

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<v Speaker 1>two films actually, okay, but back to the hydra and

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<v Speaker 1>biological immortality in the real world. Yeah, so this is

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<v Speaker 1>a major point really for all organisms. The natural world

0:12:24.760 --> 0:12:28.480
<v Speaker 1>is generally sufficient to ensure mortality. It's dangerous, It's filled

0:12:28.520 --> 0:12:34.640
<v Speaker 1>with competitors, predators, pathogens, accidents, and all manner of additional hazards. Now,

0:12:34.720 --> 0:12:37.400
<v Speaker 1>humans and their captives tend to live in a very

0:12:37.440 --> 0:12:41.079
<v Speaker 1>privileged space, largely removed from the threat of predation. At least,

0:12:41.960 --> 0:12:44.520
<v Speaker 1>you'll find other creatures with no natural predators as well.

0:12:44.559 --> 0:12:47.600
<v Speaker 1>Typically these are apex predators, but that doesn't mean they

0:12:47.640 --> 0:12:50.240
<v Speaker 1>don't have to deal with all these other dangers. Well. No,

0:12:50.440 --> 0:12:53.400
<v Speaker 1>when you think about an apex predator, just because there's

0:12:53.440 --> 0:12:56.840
<v Speaker 1>nothing that tackles it and tears it apart and eats it,

0:12:57.240 --> 0:13:00.840
<v Speaker 1>that doesn't mean that it's not subject to attacks from

0:13:00.840 --> 0:13:03.920
<v Speaker 1>its environment, right. I mean, it of course is subject

0:13:03.920 --> 0:13:06.439
<v Speaker 1>to disease. But one of the other things to think

0:13:06.440 --> 0:13:09.240
<v Speaker 1>about with an apex predator is these creatures are very

0:13:09.320 --> 0:13:13.080
<v Speaker 1>often constantly at the edge of starvation. And so when

0:13:13.120 --> 0:13:16.840
<v Speaker 1>you see the antelope running from the cheetah or something.

0:13:16.920 --> 0:13:19.680
<v Speaker 1>Of course, the cheetahs trying to kill the antelope, but

0:13:19.920 --> 0:13:23.520
<v Speaker 1>by escaping, the antelope is sort of also trying to

0:13:23.720 --> 0:13:26.959
<v Speaker 1>kill the cheetah. It is starving the cheetah to death

0:13:27.040 --> 0:13:29.760
<v Speaker 1>by escaping. The cheat is a great example too, because

0:13:29.880 --> 0:13:32.720
<v Speaker 1>either cheetah injures itself in the pursuit of a prey,

0:13:32.840 --> 0:13:36.760
<v Speaker 1>especially if it tackles prey that is a little beyond

0:13:36.800 --> 0:13:42.200
<v Speaker 1>its ability or or is potentially beyond its ability, it

0:13:42.240 --> 0:13:45.360
<v Speaker 1>can sustain an injury that results in death, not because

0:13:45.440 --> 0:13:48.760
<v Speaker 1>it becomes infected or what have you, but because say,

0:13:48.480 --> 0:13:52.319
<v Speaker 1>a wounded limb on a cheetah can mean it cannot

0:13:52.360 --> 0:13:55.400
<v Speaker 1>pursue prey and it starves. Right. This is another thing

0:13:55.440 --> 0:13:58.160
<v Speaker 1>we often fail to appreciate in the natural world is

0:13:58.200 --> 0:14:04.440
<v Speaker 1>how how absolutely damning a small injury can be to

0:14:04.679 --> 0:14:08.240
<v Speaker 1>an organism that has to hunt or escape hunters to survive.

0:14:08.559 --> 0:14:12.080
<v Speaker 1>You also, of course, have read about large cats that

0:14:12.120 --> 0:14:15.719
<v Speaker 1>have turned man killer, and uh in some of these

0:14:15.760 --> 0:14:19.240
<v Speaker 1>cases I remember correctly, Sometimes it has to do with

0:14:19.280 --> 0:14:22.840
<v Speaker 1>the decline of dental health, like their their inability to

0:14:22.920 --> 0:14:26.640
<v Speaker 1>depend on their their teeth for their traditional prey, and

0:14:26.680 --> 0:14:30.240
<v Speaker 1>it leads to sort of a desperate switch in their

0:14:30.280 --> 0:14:34.520
<v Speaker 1>their selection of prey. So anyway, most most individuals are

0:14:34.520 --> 0:14:36.920
<v Speaker 1>going to die or be killed before they can grow old,

0:14:37.520 --> 0:14:39.840
<v Speaker 1>so there's already a low probability of being alive and

0:14:39.960 --> 0:14:43.720
<v Speaker 1>reproductive at an advanced age. Still, hyders are are really

0:14:43.760 --> 0:14:45.440
<v Speaker 1>interesting because it give us a real world of world

0:14:45.480 --> 0:14:49.040
<v Speaker 1>example of how how undying creatures would work on a

0:14:49.040 --> 0:14:53.280
<v Speaker 1>biological level. They're hardy, their regenerative they have they have

0:14:53.320 --> 0:14:57.600
<v Speaker 1>evolved to thrive in harsh environments, and it actually reminds

0:14:57.600 --> 0:15:00.840
<v Speaker 1>me of an alien species that shows up in Ian

0:15:00.960 --> 0:15:03.480
<v Speaker 1>m banks. The Culture series, of course, go into the

0:15:03.480 --> 0:15:05.640
<v Speaker 1>Culture Yeah, I mean he he always managed to work

0:15:05.640 --> 0:15:09.000
<v Speaker 1>so many wonderful scientific topics into his his books, and

0:15:09.040 --> 0:15:12.160
<v Speaker 1>one of these topics is biological immortality. Alright, So we

0:15:12.200 --> 0:15:15.160
<v Speaker 1>meet in the really the very first Culture book, we

0:15:15.280 --> 0:15:19.400
<v Speaker 1>meet the Adherens. And here's just a quick quote. The

0:15:19.440 --> 0:15:22.680
<v Speaker 1>Adherens themselves had evolved on their planet a deer as

0:15:22.720 --> 0:15:25.880
<v Speaker 1>the top monster from a whole planet full of monsters.

0:15:26.440 --> 0:15:30.240
<v Speaker 1>The frenetic and savage ecology of a deer in its

0:15:30.240 --> 0:15:33.120
<v Speaker 1>early days had long since disappeared, and so had all

0:15:33.240 --> 0:15:37.200
<v Speaker 1>the other homeworld monsters. Except those in zoos. But the

0:15:37.240 --> 0:15:41.000
<v Speaker 1>Adherens had retained the intelligence that made them winners, as

0:15:41.000 --> 0:15:44.960
<v Speaker 1>well as the biological immortality, which, due to the viciousness

0:15:45.000 --> 0:15:47.400
<v Speaker 1>of the fight for survival back then, not to mention

0:15:47.400 --> 0:15:50.880
<v Speaker 1>a deer's high radiation levels, had been an evolutionary advantage

0:15:50.960 --> 0:15:54.200
<v Speaker 1>rather than a recipe for stagnation. Now, I think that

0:15:54.280 --> 0:15:56.680
<v Speaker 1>might be something interesting to come back to, maybe in

0:15:56.720 --> 0:15:59.920
<v Speaker 1>the second episode, and consider whether it would actually work

0:16:00.120 --> 0:16:04.040
<v Speaker 1>that way and what the effect of high mortality at

0:16:04.080 --> 0:16:07.240
<v Speaker 1>different stages of life would have on the life span

0:16:07.320 --> 0:16:09.800
<v Speaker 1>of an organism. Alright, Well, on that note, let's take

0:16:09.800 --> 0:16:12.200
<v Speaker 1>a quick break, and when we come back, we're gonna

0:16:12.280 --> 0:16:15.800
<v Speaker 1>roll through just a few other long living organisms, uh

0:16:15.880 --> 0:16:20.520
<v Speaker 1>that are not a hydra or an endearing thank alright,

0:16:20.520 --> 0:16:25.040
<v Speaker 1>we're back. So I mentioned the greenland shark earlier. This

0:16:25.080 --> 0:16:28.560
<v Speaker 1>one is pretty impressive because greenland sharks live where we

0:16:28.640 --> 0:16:32.920
<v Speaker 1>understand now about four hundred years uh. And this is

0:16:32.960 --> 0:16:36.200
<v Speaker 1>an exclusively wild species as well. This is not something

0:16:36.240 --> 0:16:39.360
<v Speaker 1>you're gonna find growing old and fat and an aquarium.

0:16:39.400 --> 0:16:42.840
<v Speaker 1>These are sharks generally don't do very well in aquariums. Correct. Yeah,

0:16:42.880 --> 0:16:45.680
<v Speaker 1>it's and no one has a greenland shark that I

0:16:45.760 --> 0:16:49.440
<v Speaker 1>am aware of as of this recording. At two thousand sixteen,

0:16:49.800 --> 0:16:53.800
<v Speaker 1>University of Copenhagen study estimated that one female greenland shark

0:16:54.320 --> 0:16:56.520
<v Speaker 1>UH had it was, it was at least four hundred

0:16:56.600 --> 0:16:59.360
<v Speaker 1>years old, and that the species doesn't even reach sexual

0:16:59.440 --> 0:17:04.520
<v Speaker 1>mature until one fifty. So think of that, not until

0:17:04.880 --> 0:17:07.880
<v Speaker 1>they've reached an age that exceeds every human being who

0:17:07.920 --> 0:17:11.320
<v Speaker 1>has ever lived, and that's counting unverified but not mythic

0:17:11.400 --> 0:17:15.959
<v Speaker 1>individual humans, right, not the Highlanders or you know, like

0:17:16.000 --> 0:17:20.520
<v Speaker 1>you know, biblical days. Right. Yeah. Now, of course that's

0:17:20.600 --> 0:17:25.040
<v Speaker 1>still not the oldest animal, because there was a clam

0:17:25.119 --> 0:17:29.160
<v Speaker 1>named Ming. This is the first line of a children's book.

0:17:29.200 --> 0:17:31.000
<v Speaker 1>I know it should be. Well, I would be. I

0:17:31.000 --> 0:17:33.160
<v Speaker 1>would actually be surprised if there's not a children's book

0:17:33.160 --> 0:17:35.679
<v Speaker 1>about Ming. There was a clam named Ming. Yeah, and

0:17:35.760 --> 0:17:39.120
<v Speaker 1>Ming did love to sing. Yeah, it's this here writes itself.

0:17:39.600 --> 0:17:43.560
<v Speaker 1>So technically Ming was a qua hog clam. This is

0:17:43.760 --> 0:17:46.720
<v Speaker 1>uh an Arctic variety of clam, and it was discovered

0:17:46.720 --> 0:17:49.840
<v Speaker 1>off the coast of Iceland in two thousand six Now

0:17:49.920 --> 0:17:52.480
<v Speaker 1>at the time they thought it was around four hundred

0:17:52.480 --> 0:17:54.399
<v Speaker 1>and five years old, so they named it after the

0:17:54.480 --> 0:17:57.200
<v Speaker 1>Ming dynasty that would have ruled China at this time.

0:17:58.200 --> 0:18:01.080
<v Speaker 1>Later estimates, and this is supported by urban dating, would

0:18:01.080 --> 0:18:04.480
<v Speaker 1>boost that age to five hundred and seven years half

0:18:04.520 --> 0:18:08.280
<v Speaker 1>a millennium. So this means that the creature was born

0:18:08.359 --> 0:18:13.240
<v Speaker 1>in fourteen and that's still within the Mean dynasty which

0:18:13.280 --> 0:18:18.760
<v Speaker 1>went four And to throw another point of context in there,

0:18:18.800 --> 0:18:21.320
<v Speaker 1>this was around the time that Leonardo da Vinci completed

0:18:21.359 --> 0:18:24.719
<v Speaker 1>the Last Supper. It's the year Portuguese explorer Vasco da

0:18:24.720 --> 0:18:28.800
<v Speaker 1>Gama reached India. That's when this this thing was was

0:18:28.840 --> 0:18:30.720
<v Speaker 1>born and then it died in two thousand and six,

0:18:31.119 --> 0:18:34.240
<v Speaker 1>there was a clam named Ming, and Ming remembered everything.

0:18:34.600 --> 0:18:38.120
<v Speaker 1>There you go now the plant where world, of course

0:18:38.200 --> 0:18:41.360
<v Speaker 1>has all of this beat uh. There's the great basin

0:18:41.480 --> 0:18:45.520
<v Speaker 1>bristle cone Pine or Pinus along Gava and it can

0:18:45.560 --> 0:18:48.320
<v Speaker 1>only lived to over five thousand years of age, and

0:18:48.320 --> 0:18:50.080
<v Speaker 1>that takes us back to the very end of the

0:18:50.119 --> 0:18:54.199
<v Speaker 1>Neolithic period. Work on Stonehenge had begun. This was the

0:18:54.240 --> 0:18:56.560
<v Speaker 1>age of the Pharaoh, so it lived through the rise

0:18:56.720 --> 0:18:59.320
<v Speaker 1>and the fall of the Roman Empire. Now, of course

0:18:59.359 --> 0:19:03.720
<v Speaker 1>this highlights that different kinds of organisms have massively different

0:19:03.720 --> 0:19:06.560
<v Speaker 1>potential when it comes to lifespan. Yeah, and of course

0:19:06.560 --> 0:19:09.080
<v Speaker 1>plants are very different from animals. This reminds me that

0:19:09.080 --> 0:19:11.040
<v Speaker 1>one of the ideas that was brought up recently. I

0:19:11.040 --> 0:19:14.240
<v Speaker 1>believe on our discussion module on on Facebook or Facebook group,

0:19:14.920 --> 0:19:16.879
<v Speaker 1>that we should do something just on plants, like what

0:19:17.080 --> 0:19:19.080
<v Speaker 1>is a plant? To sort of strip it down to

0:19:19.119 --> 0:19:21.800
<v Speaker 1>its basics. I kind of like that idea, it's a

0:19:21.840 --> 0:19:26.680
<v Speaker 1>really lazy animal. Well, I've got a really lazy one.

0:19:26.680 --> 0:19:30.280
<v Speaker 1>Then for you here, Uh, there's at least one step

0:19:30.320 --> 0:19:35.040
<v Speaker 1>beyond the great basin bristle Cone pine. And this is

0:19:35.040 --> 0:19:37.960
<v Speaker 1>something you'll find in fish Lake National Park in Utah

0:19:38.200 --> 0:19:41.440
<v Speaker 1>here in the United States, Uh, the quaking aspen tree,

0:19:41.760 --> 0:19:43.840
<v Speaker 1>which is also the state tree by the way, also

0:19:43.880 --> 0:19:47.480
<v Speaker 1>known as the trembling Giant or pando, which means I spread.

0:19:48.840 --> 0:19:50.760
<v Speaker 1>So what we have here and this is this is

0:19:50.760 --> 0:19:54.640
<v Speaker 1>one where not everybody necessarily agrees with that this might

0:19:54.640 --> 0:19:56.879
<v Speaker 1>be sort of bending the definition a little bit of

0:19:56.920 --> 0:19:59.280
<v Speaker 1>what is a long living organism. But what we have

0:19:59.400 --> 0:20:02.480
<v Speaker 1>here is a single clone of quaking asp been connected

0:20:02.480 --> 0:20:05.880
<v Speaker 1>by a single extensive roots system that's roughly the size

0:20:05.880 --> 0:20:08.760
<v Speaker 1>of Vatican City, a hundred and six acres thirteen million

0:20:08.800 --> 0:20:12.359
<v Speaker 1>pounds and it's all eighty thousand years old. So what

0:20:12.400 --> 0:20:16.800
<v Speaker 1>you're talking about is a forest that is all sort

0:20:16.840 --> 0:20:19.800
<v Speaker 1>of in some way the same organism. Right, you can.

0:20:19.880 --> 0:20:22.560
<v Speaker 1>It's it's not as simple as the clam was born

0:20:23.040 --> 0:20:25.679
<v Speaker 1>in the century and it died in this one. But

0:20:25.800 --> 0:20:28.080
<v Speaker 1>if you if you've been the definition enough and you

0:20:28.119 --> 0:20:31.000
<v Speaker 1>accept this as an example, we're talking about a thing

0:20:31.119 --> 0:20:34.240
<v Speaker 1>that has lived since humans first left Africa to colonized

0:20:34.280 --> 0:20:37.600
<v Speaker 1>the world. Wow. Yeah, Now, Robert, here's something I've always

0:20:37.600 --> 0:20:42.080
<v Speaker 1>wondered about. Okay, dinosaurs. You got to wonder how long

0:20:42.119 --> 0:20:44.760
<v Speaker 1>they lived, especially because this gets warped by our sense

0:20:44.800 --> 0:20:48.520
<v Speaker 1>of history. I think because they lived so long ago,

0:20:49.600 --> 0:20:52.680
<v Speaker 1>you just naturally go to this completely illogical place where

0:20:52.720 --> 0:20:57.000
<v Speaker 1>they must have lived a long time. Like, Okay, tyrannosaurs

0:20:57.040 --> 0:20:59.879
<v Speaker 1>rex lived maybe three hundred years. I mean they they

0:21:00.000 --> 0:21:02.320
<v Speaker 1>they've got very big, so you have to imagine it

0:21:02.359 --> 0:21:04.400
<v Speaker 1>took them a while to grow as big as they did.

0:21:04.800 --> 0:21:06.919
<v Speaker 1>This would take a lot of years of eating and

0:21:07.000 --> 0:21:10.479
<v Speaker 1>cell division and all that. So so surely they had

0:21:10.560 --> 0:21:14.399
<v Speaker 1>very long lifespans. Well, this used to be the main theory,

0:21:15.000 --> 0:21:17.520
<v Speaker 1>and this was in part because of ai their size

0:21:17.560 --> 0:21:19.440
<v Speaker 1>or at least the size of many of the specimens

0:21:19.760 --> 0:21:21.879
<v Speaker 1>and the fact that we thought, well, they were essentially

0:21:22.440 --> 0:21:26.119
<v Speaker 1>giant reptiles, and so based on slow reptile growth rates

0:21:26.119 --> 0:21:28.560
<v Speaker 1>and their size, they said, well, big dinos probably lived

0:21:28.720 --> 0:21:32.240
<v Speaker 1>several hundred years. But today paleonto just believed they grew

0:21:32.560 --> 0:21:35.480
<v Speaker 1>more like birds and mammals, and this cuts back on

0:21:35.520 --> 0:21:39.080
<v Speaker 1>their lifespans somewhat. So, for instance, the Field Museum of

0:21:39.160 --> 0:21:42.720
<v Speaker 1>Chicago they have this, uh, this these t rex remains

0:21:43.240 --> 0:21:46.280
<v Speaker 1>that they named Sue. Sue. Sue is great. Yeah, she's

0:21:46.280 --> 0:21:48.679
<v Speaker 1>a wonderful specimen. You get to look right up at

0:21:48.680 --> 0:21:51.520
<v Speaker 1>her and get a sense of the true size of

0:21:51.560 --> 0:21:54.960
<v Speaker 1>this this amazing species. Can I say something embarrassing, go

0:21:55.080 --> 0:21:56.960
<v Speaker 1>for it. I cried a little bit at Sue. Yeah,

0:21:57.040 --> 0:22:00.240
<v Speaker 1>I'm not kidding. When we were in Chicago and I'm

0:22:00.280 --> 0:22:03.080
<v Speaker 1>just sitting there looking at Sue for a while, I

0:22:03.119 --> 0:22:06.680
<v Speaker 1>did something to me a little misty. That's that's beautiful.

0:22:06.920 --> 0:22:09.000
<v Speaker 1>I I can understand it because it is like looking

0:22:09.000 --> 0:22:11.520
<v Speaker 1>back in time to encounter, you know, a fossil like that.

0:22:12.400 --> 0:22:16.200
<v Speaker 1>So Sue is a rather big specimen, or at least

0:22:16.960 --> 0:22:19.280
<v Speaker 1>the fossil remains are rather large and speak to a

0:22:19.359 --> 0:22:23.640
<v Speaker 1>large specimen. They we think now that she probably achieved

0:22:23.680 --> 0:22:26.400
<v Speaker 1>adult size at age twenty and lived to a ripe

0:22:26.440 --> 0:22:31.000
<v Speaker 1>old age of twenty nine. So I am now older

0:22:31.400 --> 0:22:36.200
<v Speaker 1>than than this Tyrannosaurus rex was when it dies exactly. Yeah,

0:22:36.320 --> 0:22:38.639
<v Speaker 1>and uh, and you just underlines that what you had

0:22:38.680 --> 0:22:41.600
<v Speaker 1>with the dinosaurs was likely rapid growth but short lives.

0:22:42.400 --> 0:22:46.360
<v Speaker 1>Now one sort of side question that we won't fully explore.

0:22:46.440 --> 0:22:49.199
<v Speaker 1>But this this may raise the question, well, dinosaurs have

0:22:49.320 --> 0:22:52.960
<v Speaker 1>cancer because you're thinking about rapid growth, right of course. Well,

0:22:53.600 --> 0:22:55.320
<v Speaker 1>basically this is the question we have to come back to.

0:22:55.440 --> 0:22:57.760
<v Speaker 1>But based on the research I was looking at, we

0:22:57.840 --> 0:23:01.040
<v Speaker 1>only have evidence of the haddress sores the duck build

0:23:01.040 --> 0:23:05.360
<v Speaker 1>dinosaurs developing any form of cancer. Now that's the caveat

0:23:05.440 --> 0:23:08.239
<v Speaker 1>that's the only the only ones we have evidence of

0:23:08.240 --> 0:23:11.479
<v Speaker 1>that that occurring in. But it is interesting to think

0:23:11.520 --> 0:23:14.399
<v Speaker 1>of like the late model dinosaur as being the place

0:23:14.400 --> 0:23:17.040
<v Speaker 1>where we see the cancer showing up. We got to

0:23:17.080 --> 0:23:19.199
<v Speaker 1>come back and do an episode on dinosaur cancer in

0:23:19.200 --> 0:23:21.520
<v Speaker 1>the future. Yeah, by all means, well, I want to

0:23:21.520 --> 0:23:23.560
<v Speaker 1>do something that we often end up having to do,

0:23:23.600 --> 0:23:26.280
<v Speaker 1>which is that after we've explored a concept for a while,

0:23:26.320 --> 0:23:30.080
<v Speaker 1>it becomes more and more complicated, and our lay definition

0:23:30.280 --> 0:23:34.120
<v Speaker 1>starts to get a little less useful. So I think

0:23:34.160 --> 0:23:38.880
<v Speaker 1>maybe we should ask the question what actually is aging? Now?

0:23:39.040 --> 0:23:43.240
<v Speaker 1>We have a pretty uh intuitive, gut level understanding of

0:23:43.280 --> 0:23:45.440
<v Speaker 1>what aging is. We know when we see it, But

0:23:45.520 --> 0:23:47.800
<v Speaker 1>how would you define it? I mean, it's it is

0:23:47.840 --> 0:23:53.000
<v Speaker 1>something different from death, and it is something different from

0:23:53.080 --> 0:23:56.040
<v Speaker 1>just like, I don't know, your skin getting wrinkles or

0:23:56.080 --> 0:23:58.920
<v Speaker 1>something like that. What what is the actual scientific thing

0:23:58.960 --> 0:24:03.840
<v Speaker 1>that all of the stuff we call aging has in common. Well,

0:24:03.880 --> 0:24:07.800
<v Speaker 1>this is a great question. I mean, on one hand,

0:24:07.200 --> 0:24:10.320
<v Speaker 1>it is closely tied to death, and I think one

0:24:10.320 --> 0:24:12.720
<v Speaker 1>of the stumbling blocks is that will will alreadily admit

0:24:12.760 --> 0:24:15.439
<v Speaker 1>that aging is something that our body does, but we

0:24:15.480 --> 0:24:17.320
<v Speaker 1>tend there's tends to it tends to be a cultural

0:24:17.359 --> 0:24:19.760
<v Speaker 1>bearer in place to saying that death is something our

0:24:19.800 --> 0:24:23.000
<v Speaker 1>body does. We like to push that off onto some

0:24:23.040 --> 0:24:28.159
<v Speaker 1>sort of external force of of fade or anthropomorphized dread,

0:24:28.400 --> 0:24:30.399
<v Speaker 1>you know, or some sort of limit imposed on us

0:24:30.440 --> 0:24:33.360
<v Speaker 1>by the gods. Well, yeah, yeah, death is something that

0:24:33.440 --> 0:24:37.480
<v Speaker 1>we more often characterize as happening to us. Death happens

0:24:37.520 --> 0:24:41.119
<v Speaker 1>to you. It's not something you do, though, there you

0:24:41.160 --> 0:24:44.679
<v Speaker 1>can kind of see that the division between the death

0:24:44.720 --> 0:24:46.399
<v Speaker 1>and the aging death I was talking about at the

0:24:46.440 --> 0:24:49.480
<v Speaker 1>beginning of this episode comes into focus, because of course

0:24:49.560 --> 0:24:51.680
<v Speaker 1>death can happen to you if you get a rock

0:24:51.840 --> 0:24:54.359
<v Speaker 1>jammed through your you know, through your body or something

0:24:54.400 --> 0:24:58.840
<v Speaker 1>like that. But the body does seem to naturally progress

0:24:58.960 --> 0:25:02.760
<v Speaker 1>toward death of time, and that's kind of a weird question,

0:25:02.800 --> 0:25:06.280
<v Speaker 1>like why would it do that. We will definitely explore

0:25:06.320 --> 0:25:08.920
<v Speaker 1>the science behind that question in the second episode that

0:25:09.040 --> 0:25:11.560
<v Speaker 1>we will look at some archaic ancers to it in

0:25:11.600 --> 0:25:13.879
<v Speaker 1>this one, because when especially with the human, with the

0:25:13.960 --> 0:25:18.800
<v Speaker 1>human experience of aging and death, it seems completely illogical

0:25:18.920 --> 0:25:22.280
<v Speaker 1>that in many cases a human being would spend the

0:25:22.320 --> 0:25:26.840
<v Speaker 1>majority of its life progressing towards death, Like the majority

0:25:26.880 --> 0:25:30.879
<v Speaker 1>of your life is declined. Uh, that just feels either

0:25:31.920 --> 0:25:35.160
<v Speaker 1>gross or cruel or just like a horrible design flaw

0:25:35.400 --> 0:25:39.320
<v Speaker 1>or yeah, or nonsensical. Where's my eternal youth? Doesn't make

0:25:39.359 --> 0:25:44.359
<v Speaker 1>any sense? Um? So. In his book The Evolutionary Biology

0:25:44.359 --> 0:25:48.760
<v Speaker 1>of Aging published by Oxford University Press, the biologist Michael R.

0:25:48.880 --> 0:25:53.159
<v Speaker 1>Rose defined aging in the following way quote a persistent

0:25:53.240 --> 0:25:58.160
<v Speaker 1>decline in the age specific fitness components of an organism

0:25:58.240 --> 0:26:04.200
<v Speaker 1>due to internal physic eological deterioration. Now Rose actually has

0:26:04.320 --> 0:26:06.679
<v Speaker 1>offered has said that in some ways we might need

0:26:06.720 --> 0:26:09.280
<v Speaker 1>to update that understanding a little bit to accommodate for

0:26:09.359 --> 0:26:11.560
<v Speaker 1>some new discoveries. But I think this is a good

0:26:11.560 --> 0:26:14.119
<v Speaker 1>place to start. So let's look at the parts of

0:26:14.160 --> 0:26:18.440
<v Speaker 1>that definition. Number one, it's persistent decline, which means aging

0:26:18.640 --> 0:26:21.960
<v Speaker 1>only goes one way. It's not characterized by say decline

0:26:22.000 --> 0:26:26.000
<v Speaker 1>and rebound. And some organisms do have patterns like this

0:26:26.160 --> 0:26:28.119
<v Speaker 1>is not quite aging, like you can think about the

0:26:28.200 --> 0:26:32.439
<v Speaker 1>jellyfish that have regenerative capabilities where they can revert to

0:26:32.600 --> 0:26:36.880
<v Speaker 1>a younger stage of life. But then so it's persistent decline.

0:26:37.320 --> 0:26:42.000
<v Speaker 1>And then in the quote age specific fitness components biological

0:26:42.000 --> 0:26:46.200
<v Speaker 1>fitness meaning the ability to survive and reproduce. So these

0:26:46.200 --> 0:26:48.879
<v Speaker 1>are the things that are persistently in decline. You become

0:26:48.960 --> 0:26:53.320
<v Speaker 1>less able to survive and less able to reproduce. And

0:26:53.359 --> 0:26:57.960
<v Speaker 1>then it's due to internal physiological deterioration. So it's saying

0:26:57.960 --> 0:27:01.199
<v Speaker 1>that this persistent decline in the ability to survive and

0:27:01.240 --> 0:27:05.560
<v Speaker 1>reproduce is not due to disease or injury, but to

0:27:05.960 --> 0:27:11.320
<v Speaker 1>something deteriorating within the body. Tissues themselves, yeah, this is

0:27:11.560 --> 0:27:13.280
<v Speaker 1>this makes me think, of course, of the phrase cradle

0:27:13.320 --> 0:27:16.560
<v Speaker 1>to the grave and with the with the hydra. The

0:27:16.720 --> 0:27:18.800
<v Speaker 1>cradle to the grave is kind of a straight line

0:27:18.840 --> 0:27:23.679
<v Speaker 1>with reproduction taking place at all levels until something happens

0:27:23.720 --> 0:27:28.040
<v Speaker 1>to kill it. Whereas most of the models that that

0:27:28.119 --> 0:27:29.560
<v Speaker 1>we look at, most of the models we looked at

0:27:29.680 --> 0:27:32.600
<v Speaker 1>in researching this episode, it's more of a of a

0:27:32.800 --> 0:27:36.880
<v Speaker 1>rise rising and lowering. There's a rise towards like peak

0:27:36.960 --> 0:27:42.760
<v Speaker 1>sexual maturity, peak reproductive maturity, and then a decline. Yeah. Yeah,

0:27:42.840 --> 0:27:45.520
<v Speaker 1>and then it gets even stickier, right because we we've

0:27:45.560 --> 0:27:47.679
<v Speaker 1>just tried to be very careful and how we're defining this.

0:27:47.720 --> 0:27:50.399
<v Speaker 1>But then I realized that I said the it's a

0:27:50.440 --> 0:27:53.360
<v Speaker 1>decline in the ability to survive and reproduce, not due

0:27:53.400 --> 0:27:56.520
<v Speaker 1>to disease or injury. But a lot of the things

0:27:56.600 --> 0:28:01.240
<v Speaker 1>that are the characteristic signals of aging are sometimes thought

0:28:01.280 --> 0:28:05.360
<v Speaker 1>of as diseases, even though maybe they're not caused by

0:28:05.520 --> 0:28:09.720
<v Speaker 1>say a germ or something. Uh. There are all kinds

0:28:09.720 --> 0:28:15.080
<v Speaker 1>of things like diabetes melitas, or like rheumatoid arthritis that

0:28:15.160 --> 0:28:19.199
<v Speaker 1>are totally characteristic signs of aging and human beings, and

0:28:19.200 --> 0:28:22.560
<v Speaker 1>they're thought of as diseases. But they're not so much

0:28:22.640 --> 0:28:26.120
<v Speaker 1>something that gets done to the body by external forces.

0:28:26.200 --> 0:28:28.520
<v Speaker 1>There are a thing that happens when the body is

0:28:28.560 --> 0:28:31.880
<v Speaker 1>around for a long time under certain conditions. It makes

0:28:31.920 --> 0:28:35.040
<v Speaker 1>me think back to our episode on Chinese immortality and

0:28:35.080 --> 0:28:38.120
<v Speaker 1>about the the idea of the the older body being

0:28:38.240 --> 0:28:41.760
<v Speaker 1>kind of an alien body, Like it's a different biology.

0:28:41.920 --> 0:28:47.840
<v Speaker 1>We're changing into a different being with different physical characteristics,

0:28:48.280 --> 0:28:53.880
<v Speaker 1>generally characteristics that that lean towards towards weakness. Absolutely, But

0:28:53.920 --> 0:28:57.320
<v Speaker 1>then again, you can also look at aging through the microscope,

0:28:57.440 --> 0:28:59.520
<v Speaker 1>look at it on the cellular level, and this is

0:28:59.560 --> 0:29:03.920
<v Speaker 1>where you'll often see people using words like senescence. Defined

0:29:03.960 --> 0:29:08.480
<v Speaker 1>by by Nature's scientific glossory quote, senescence is the process

0:29:08.520 --> 0:29:13.200
<v Speaker 1>by which cells irreversibly stop dividing and inter a state

0:29:13.240 --> 0:29:18.640
<v Speaker 1>of permanent growth arrest without undergoing cell death. Senescence can

0:29:18.720 --> 0:29:22.960
<v Speaker 1>be induced by unrepaired DNA damage or other cellular stresses.

0:29:23.440 --> 0:29:25.760
<v Speaker 1>So this is looking at it on the microscopic level

0:29:25.800 --> 0:29:30.840
<v Speaker 1>and saying senescence, often used as as a synonym for aging,

0:29:31.200 --> 0:29:36.760
<v Speaker 1>happens when the cells stop making new rejuvenated cells. This

0:29:36.840 --> 0:29:39.960
<v Speaker 1>is kind of the lack of upkeep keep model. It's

0:29:39.960 --> 0:29:42.720
<v Speaker 1>the idea that well, the house is falling apart because

0:29:42.760 --> 0:29:45.160
<v Speaker 1>nobody's working on it, nobody's maintaining, or at least the

0:29:45.400 --> 0:29:49.920
<v Speaker 1>maintenance has really been scaled back or it's all. It's

0:29:49.960 --> 0:29:52.640
<v Speaker 1>been my experience thus far with aging that you find

0:29:53.240 --> 0:29:57.320
<v Speaker 1>the maintenance requests are are kind of rolled out in

0:29:57.320 --> 0:30:01.000
<v Speaker 1>an a logical way where you you may think yourself, well,

0:30:01.040 --> 0:30:04.040
<v Speaker 1>why am I still sore from this injury I sustained

0:30:04.160 --> 0:30:07.160
<v Speaker 1>last month? But my my, what my body is really

0:30:07.160 --> 0:30:09.600
<v Speaker 1>trying to do is like grow a bunch of nose hair.

0:30:10.080 --> 0:30:13.040
<v Speaker 1>You know, it's like, why why is that the the

0:30:13.680 --> 0:30:16.960
<v Speaker 1>main operative that's been passed down to my body? You know,

0:30:17.200 --> 0:30:18.920
<v Speaker 1>everything is beginning to get out of whack. It's as

0:30:18.960 --> 0:30:22.680
<v Speaker 1>if it's as if there's nobody in charge anymore. Uh,

0:30:22.680 --> 0:30:25.880
<v Speaker 1>and they're just letting the house fall apart. Yeah, if

0:30:25.920 --> 0:30:29.160
<v Speaker 1>you were the superintendent of an apartment building, it would

0:30:29.200 --> 0:30:31.880
<v Speaker 1>be like, there's a water leak in the basement that

0:30:31.960 --> 0:30:35.320
<v Speaker 1>has not been fixed for months, and your repair person

0:30:35.520 --> 0:30:38.400
<v Speaker 1>is busy building hundreds of kitchen cabinets on the roof.

0:30:38.600 --> 0:30:40.680
<v Speaker 1>Yeah yeah, and you think, well, in the old days,

0:30:41.080 --> 0:30:42.880
<v Speaker 1>we we didn't have all these kitchen cabinets on the

0:30:42.960 --> 0:30:45.360
<v Speaker 1>roof and things got fixed. Why do things not got

0:30:45.440 --> 0:30:47.800
<v Speaker 1>to get fixed anymore? That is a great question, and

0:30:47.840 --> 0:30:50.880
<v Speaker 1>I guess we should try to look at some answers

0:30:50.920 --> 0:30:54.840
<v Speaker 1>to that when we come back from this next break.

0:30:53.440 --> 0:30:57.240
<v Speaker 1>Than alright, we're back, all right, So let's look at

0:30:57.320 --> 0:31:00.640
<v Speaker 1>some historical and lay answers to the question, and why

0:31:00.760 --> 0:31:04.000
<v Speaker 1>do we age? What's the point? Why does it happen?

0:31:04.840 --> 0:31:07.640
<v Speaker 1>One common example that seems to make sense to people

0:31:07.720 --> 0:31:10.160
<v Speaker 1>is the idea that our body is over time quote

0:31:10.320 --> 0:31:15.720
<v Speaker 1>get worn out. Uh So. In his nine paper Pleotropy,

0:31:15.840 --> 0:31:18.720
<v Speaker 1>Natural Selection and the Evolution of Senescence, which we will

0:31:18.760 --> 0:31:21.680
<v Speaker 1>definitely come back to in the second episode here, the

0:31:21.720 --> 0:31:25.880
<v Speaker 1>American biologist George C. Williams pointed out that one problem

0:31:25.920 --> 0:31:30.960
<v Speaker 1>explaining the true biological reason behind aging is that many

0:31:31.000 --> 0:31:34.240
<v Speaker 1>people think they already understand what aging is and why

0:31:34.280 --> 0:31:37.400
<v Speaker 1>it happens. And they're wrong. They're wrong. But if you

0:31:37.440 --> 0:31:39.800
<v Speaker 1>think you've already got the answer, you'll never go asking

0:31:39.840 --> 0:31:43.160
<v Speaker 1>the question and writing of these kind of folk explanations

0:31:43.240 --> 0:31:47.680
<v Speaker 1>for aging. He says, quote the most injurious of these

0:31:47.800 --> 0:31:51.760
<v Speaker 1>is the identification of senescence with the quote wearing out

0:31:52.360 --> 0:31:56.160
<v Speaker 1>That is shown by human artifacts, And doesn't this seem

0:31:56.400 --> 0:31:59.600
<v Speaker 1>very sensical? Right? Our tools get worn out over time.

0:32:00.040 --> 0:32:02.480
<v Speaker 1>If you use a knife a whole lot, eventually it'll

0:32:02.480 --> 0:32:06.320
<v Speaker 1>lose the sharpness of its blade. Uh, any tool you

0:32:06.480 --> 0:32:09.560
<v Speaker 1>use too much. I'm thinking about a broom that we

0:32:09.680 --> 0:32:12.080
<v Speaker 1>used to have for years around our house that eventually

0:32:12.120 --> 0:32:14.120
<v Speaker 1>got worn down to nubs. There were just really no

0:32:14.200 --> 0:32:17.400
<v Speaker 1>bristles on it anymore. Shouldn't our bodies be the same.

0:32:18.240 --> 0:32:20.800
<v Speaker 1>This reminds me I've had to explain this to my

0:32:20.800 --> 0:32:24.080
<v Speaker 1>my son recently, where he'll get some sort of cheap toy,

0:32:24.240 --> 0:32:27.040
<v Speaker 1>you know, as a prize or something, and uh, and

0:32:27.160 --> 0:32:29.080
<v Speaker 1>he'll be really into it, and I'll have to explain

0:32:29.320 --> 0:32:31.000
<v Speaker 1>to him that this is not the sort of toy

0:32:31.040 --> 0:32:34.719
<v Speaker 1>that lasts very long. You know, toys like this may

0:32:34.880 --> 0:32:37.760
<v Speaker 1>last a week or so. And He's like, no, some

0:32:37.760 --> 0:32:39.800
<v Speaker 1>some toys last forever. And I'm like, well, they don't.

0:32:39.880 --> 0:32:42.760
<v Speaker 1>They don't. Really, you have to try to explain how

0:32:42.920 --> 0:32:46.400
<v Speaker 1>pretty much everything that is made by man is going

0:32:46.440 --> 0:32:49.840
<v Speaker 1>to fall apart. Okay, after I finished my children's book

0:32:49.880 --> 0:32:53.120
<v Speaker 1>about ming the clam, I'm writing a second children's book

0:32:53.160 --> 0:32:57.280
<v Speaker 1>called Toys Die. What it reminds me of the short

0:32:57.360 --> 0:33:01.400
<v Speaker 1>story that that A I was was based on. Oh yeah,

0:33:01.440 --> 0:33:03.120
<v Speaker 1>I forget the exact title, but to believe it was

0:33:03.320 --> 0:33:06.080
<v Speaker 1>Super Toys Last All Summer, which I always thought was

0:33:07.120 --> 0:33:11.400
<v Speaker 1>a rather fun title. That is great, But knowing knowing that,

0:33:11.480 --> 0:33:13.640
<v Speaker 1>we also know that they won't last forever, like you,

0:33:13.760 --> 0:33:17.440
<v Speaker 1>like you say so. Going back to what Williams wrote, quote,

0:33:18.320 --> 0:33:21.720
<v Speaker 1>A moment of serious consideration should convince a biologist of

0:33:21.760 --> 0:33:25.920
<v Speaker 1>the fundamental dissimilarity between these two processes, meaning the body

0:33:25.960 --> 0:33:29.960
<v Speaker 1>wearing out and tools wearing out. The breakdown of human

0:33:30.080 --> 0:33:35.080
<v Speaker 1>artifacts is strictly mechanical and is readily cured by mechanical repairs.

0:33:35.560 --> 0:33:38.960
<v Speaker 1>The system is a static one, since the same material

0:33:39.080 --> 0:33:43.280
<v Speaker 1>is continuously present and there is no endogenous change with

0:33:43.360 --> 0:33:46.600
<v Speaker 1>the passage of time. An organism, on the other hand,

0:33:46.760 --> 0:33:50.160
<v Speaker 1>is an open system in a state of material flux.

0:33:50.720 --> 0:33:56.840
<v Speaker 1>Even such structures as bones maintain constant exchanges with the environment. Moreover,

0:33:56.960 --> 0:34:01.440
<v Speaker 1>an organism produces itself by a morphogen netic process. It

0:34:01.560 --> 0:34:05.080
<v Speaker 1>is indeed remarkable that after a seemingly miraculous feat of

0:34:05.160 --> 0:34:09.360
<v Speaker 1>morphogenesis and that means like growing into the adult shape,

0:34:10.160 --> 0:34:13.600
<v Speaker 1>a metazoan should be unable to perform the much simpler

0:34:13.680 --> 0:34:17.640
<v Speaker 1>task of merely maintaining what is already formed. I think

0:34:17.680 --> 0:34:19.879
<v Speaker 1>this is a fantastic point. I mean, it doesn't make

0:34:19.920 --> 0:34:22.279
<v Speaker 1>sense to say we get old because over time our

0:34:22.320 --> 0:34:24.600
<v Speaker 1>bodies just get worn out. Because our bodies have the

0:34:24.640 --> 0:34:28.200
<v Speaker 1>ability to rejuvenate tissues. They built the tissues in the

0:34:28.200 --> 0:34:30.680
<v Speaker 1>first place, they could just keep building them as long

0:34:30.719 --> 0:34:33.400
<v Speaker 1>as they wanted. Yeah, I mean, I think part of

0:34:33.400 --> 0:34:35.239
<v Speaker 1>this is the I mean part of it is just

0:34:35.320 --> 0:34:37.520
<v Speaker 1>that we are so close to the aging process. We

0:34:37.600 --> 0:34:40.680
<v Speaker 1>experience it and we see it in others. Uh, we're

0:34:40.719 --> 0:34:43.279
<v Speaker 1>almost too close to it to have an objective view

0:34:43.320 --> 0:34:45.719
<v Speaker 1>of it. And then to your point, we're informed by

0:34:45.960 --> 0:34:49.239
<v Speaker 1>what happens to our tools. And then I also they're

0:34:49.680 --> 0:34:52.319
<v Speaker 1>tying into the experience as well, and the wearing out

0:34:52.320 --> 0:34:55.440
<v Speaker 1>of things. I think dental health has a has a

0:34:55.520 --> 0:34:58.520
<v Speaker 1>huge impact on it because we observe this happening with

0:34:58.560 --> 0:35:01.919
<v Speaker 1>our very teeth. Teeth of others that you get that

0:35:02.000 --> 0:35:04.600
<v Speaker 1>those adult teeth in and those are the ones you're

0:35:04.600 --> 0:35:06.799
<v Speaker 1>going to have for the rest of your life as

0:35:06.880 --> 0:35:09.279
<v Speaker 1>long as you can keep them. You know they are

0:35:09.320 --> 0:35:12.440
<v Speaker 1>going to wear out, and unlike other organisms, there's not

0:35:12.480 --> 0:35:15.680
<v Speaker 1>going to be an additional set there that are going

0:35:15.719 --> 0:35:21.120
<v Speaker 1>to lock into place. Third children's book for when children

0:35:21.200 --> 0:35:23.680
<v Speaker 1>get their baby teeth knocked out, it's called this is

0:35:23.680 --> 0:35:29.279
<v Speaker 1>your Last Chance. Yeah, I've actually heard parents, I think

0:35:29.280 --> 0:35:32.279
<v Speaker 1>half joking, we talk about not worrying with brushing that

0:35:32.360 --> 0:35:34.719
<v Speaker 1>much for young children because now they're gonna go they're

0:35:34.719 --> 0:35:36.759
<v Speaker 1>gonna get that second pit. You know they're gonna be

0:35:36.920 --> 0:35:39.040
<v Speaker 1>These are not even these are just the baby teeth.

0:35:39.080 --> 0:35:40.799
<v Speaker 1>Wait till the adult teeth come in and then start

0:35:40.800 --> 0:35:45.239
<v Speaker 1>worrying about Yeah. Now, beyond these simple folk explanations, we

0:35:45.280 --> 0:35:47.600
<v Speaker 1>know that there have been lots of thinkers throughout history

0:35:47.640 --> 0:35:51.240
<v Speaker 1>who must have tried to explain why aging happens before

0:35:51.280 --> 0:35:56.640
<v Speaker 1>we had modern modern genetics to really understand the true mechanisms. Right, Yeah,

0:35:56.920 --> 0:35:59.800
<v Speaker 1>this is you know, aging is part of the human experience,

0:35:59.840 --> 0:36:01.920
<v Speaker 1>and so some of the great thinkers and human history

0:36:01.960 --> 0:36:04.800
<v Speaker 1>have pondered it. We have a few examples here to

0:36:04.880 --> 0:36:11.040
<v Speaker 1>run through. For instance, Lucretius B. C. E uh he

0:36:11.320 --> 0:36:14.600
<v Speaker 1>wrote about it in his text on the Nature of Things,

0:36:15.280 --> 0:36:17.880
<v Speaker 1>and he argued that aging and death are beneficial because

0:36:17.880 --> 0:36:20.680
<v Speaker 1>they make room for the next generation. This is probably

0:36:20.719 --> 0:36:23.359
<v Speaker 1>another folk explanation. A lot of people would employ. Right,

0:36:23.400 --> 0:36:25.759
<v Speaker 1>It totally seems to make sense. You can't just keep

0:36:25.800 --> 0:36:27.680
<v Speaker 1>living forever because you've got to make room for the

0:36:27.719 --> 0:36:32.880
<v Speaker 1>next generation. Yeah. It especially makes a sort of sense,

0:36:32.920 --> 0:36:35.759
<v Speaker 1>I think for human populations when you have, say, individuals

0:36:35.840 --> 0:36:40.160
<v Speaker 1>who have over the course of their lifetime, accumulated certain

0:36:40.239 --> 0:36:44.040
<v Speaker 1>benefits and powers and possessions. And then the idea as well,

0:36:44.080 --> 0:36:47.800
<v Speaker 1>when they fall away, those resources spread to someone else,

0:36:47.840 --> 0:36:50.160
<v Speaker 1>you know, I mean we we we have always lived

0:36:50.160 --> 0:36:53.879
<v Speaker 1>in a world of of finite resources. And I want

0:36:53.880 --> 0:36:56.759
<v Speaker 1>to be clear, it is good that that happens. The

0:36:56.800 --> 0:37:00.800
<v Speaker 1>next generations actually do benefit from the fact that older

0:37:00.800 --> 0:37:04.319
<v Speaker 1>generations grow old and die. Uh, but there are some

0:37:04.360 --> 0:37:08.520
<v Speaker 1>serious problems with thinking about this as the reason biologically

0:37:08.640 --> 0:37:11.560
<v Speaker 1>that they grow old and die. Yeah. Though this this

0:37:11.600 --> 0:37:14.760
<v Speaker 1>observation persisted well up into the twentieth century. For instance,

0:37:14.840 --> 0:37:19.239
<v Speaker 1>nineteenth century German biologist August Weismann also believe that the

0:37:19.280 --> 0:37:22.040
<v Speaker 1>death mechanism created room for the next generation of young

0:37:22.120 --> 0:37:25.319
<v Speaker 1>to thrive at And you know, I have to men

0:37:25.360 --> 0:37:27.600
<v Speaker 1>as well that I always it always, I always kind

0:37:27.600 --> 0:37:29.400
<v Speaker 1>of felt this was the case, you know, at a

0:37:29.480 --> 0:37:33.239
<v Speaker 1>gut level, without putting a lot of serious thought behind it.

0:37:33.360 --> 0:37:36.320
<v Speaker 1>Oh yeah. Before I investigated this, I assumed something along

0:37:36.360 --> 0:37:38.840
<v Speaker 1>these lines. But then I started to doubt myself because

0:37:38.880 --> 0:37:41.239
<v Speaker 1>I was like, oh, wait a minute, that's group selection

0:37:41.360 --> 0:37:44.480
<v Speaker 1>and I always feel iffy about that. The problem here

0:37:44.560 --> 0:37:47.239
<v Speaker 1>is pointed out by Daniel Fabian of the Institute of

0:37:47.280 --> 0:37:51.480
<v Speaker 1>Population Genetics in in the publication Nature is that quote

0:37:51.520 --> 0:37:55.240
<v Speaker 1>the cost of death to individuals likely exceeds the benefit

0:37:55.320 --> 0:37:59.040
<v Speaker 1>to the group or species. And because long lived individuals

0:37:59.120 --> 0:38:03.080
<v Speaker 1>leave more off ring been short lived individuals given equivalent

0:38:03.400 --> 0:38:08.399
<v Speaker 1>reproductive output, selection would not favor such a death mechanism. Yeah.

0:38:08.440 --> 0:38:11.719
<v Speaker 1>This is one of the classic arguments against any kind

0:38:11.840 --> 0:38:16.000
<v Speaker 1>of group level selection influence. And we can revisit this

0:38:16.040 --> 0:38:19.080
<v Speaker 1>in more detail in the second episode. Now, of course,

0:38:19.120 --> 0:38:24.319
<v Speaker 1>another great thinker is Aristotle, right yeah, and he of

0:38:24.360 --> 0:38:27.719
<v Speaker 1>course wrote about this as well in on Longevity and

0:38:27.760 --> 0:38:31.360
<v Speaker 1>Shortness of Life. Aristotle tell us how it is? All right? Well,

0:38:32.640 --> 0:38:34.879
<v Speaker 1>before I got going here, I do want to point

0:38:34.880 --> 0:38:36.640
<v Speaker 1>out I I am going to be the last person

0:38:36.719 --> 0:38:41.640
<v Speaker 1>to to criticize Aristotle. Uh. I feel like he uh

0:38:42.239 --> 0:38:45.000
<v Speaker 1>he did did a lot with the wisdom of the day, obviously,

0:38:45.480 --> 0:38:48.680
<v Speaker 1>and that's an understatement. Uh, but he was not able

0:38:49.239 --> 0:38:51.560
<v Speaker 1>if We're not going to take the opinion that Aristotle

0:38:51.680 --> 0:38:55.080
<v Speaker 1>was dumb though I was talking. I was actually talking

0:38:55.080 --> 0:38:57.440
<v Speaker 1>about this with my my wife last night when I

0:38:57.480 --> 0:39:01.239
<v Speaker 1>was running through the material I'm about to to relate here,

0:39:01.600 --> 0:39:03.360
<v Speaker 1>and she said, well, that would actually make a wonderful

0:39:03.440 --> 0:39:07.520
<v Speaker 1>like BuzzFeed style article like six things that dummy Aristotle

0:39:07.560 --> 0:39:10.399
<v Speaker 1>got wrong. I mean, he got a lot of stuff wrong,

0:39:10.480 --> 0:39:12.560
<v Speaker 1>but I mean everybody in the ancient world did. I

0:39:12.560 --> 0:39:14.799
<v Speaker 1>mean he people just didn't know what we knew today, right,

0:39:14.840 --> 0:39:17.000
<v Speaker 1>and he was attempting and attempting to figure it out.

0:39:17.160 --> 0:39:19.120
<v Speaker 1>He threw out a number of hypotheses that were not

0:39:19.600 --> 0:39:22.040
<v Speaker 1>that did not shake out. So here are just a

0:39:22.640 --> 0:39:25.280
<v Speaker 1>few quotes from the work that will give you an

0:39:25.320 --> 0:39:27.960
<v Speaker 1>idea of where he was going. The reasons for some

0:39:28.000 --> 0:39:30.560
<v Speaker 1>animals being long lived and other short lived and in

0:39:30.600 --> 0:39:33.840
<v Speaker 1>a word, causes of the length and brevity of life

0:39:34.000 --> 0:39:38.120
<v Speaker 1>call for investigation. Fair enough, Yeah, same question, we're asking

0:39:38.160 --> 0:39:40.319
<v Speaker 1>why does it happen? And then he goes on to

0:39:40.440 --> 0:39:44.080
<v Speaker 1>say race is inhabiting warm countries have longer life, those

0:39:44.120 --> 0:39:47.319
<v Speaker 1>living in cold climates have a shorter time. Likewise, there

0:39:47.360 --> 0:39:51.080
<v Speaker 1>are similar differences among individuals occupying the same locality. I

0:39:51.080 --> 0:39:53.719
<v Speaker 1>don't know if that's true. I mean, we already touched

0:39:53.760 --> 0:39:56.440
<v Speaker 1>on the greenland shark, and I think we've gone more

0:39:56.440 --> 0:39:58.319
<v Speaker 1>in depth in the greenland shark in the past on

0:39:58.360 --> 0:40:01.640
<v Speaker 1>this show. But a part of it is its environment,

0:40:01.680 --> 0:40:05.560
<v Speaker 1>which is quite cold. Okay uh. He also commented on

0:40:05.640 --> 0:40:08.080
<v Speaker 1>the connection between the soul and the body. The soul

0:40:08.200 --> 0:40:11.120
<v Speaker 1>must stand in a different case in respect of its

0:40:11.239 --> 0:40:15.520
<v Speaker 1>union with the body. And then this at least rings true,

0:40:15.680 --> 0:40:18.960
<v Speaker 1>hints to all things are at all times in a

0:40:19.000 --> 0:40:23.080
<v Speaker 1>state of transition and are coming into being and passing away. Okay,

0:40:23.160 --> 0:40:26.560
<v Speaker 1>So this could be interpreted to mean something kind of

0:40:26.600 --> 0:40:29.680
<v Speaker 1>like the fact that we're constantly undergoing cell division and

0:40:29.760 --> 0:40:33.040
<v Speaker 1>our bodies maintain them I mean, obviously Aristotle didn't know this,

0:40:33.160 --> 0:40:36.120
<v Speaker 1>but that our bodies maintain themselves through cell division and

0:40:36.160 --> 0:40:40.280
<v Speaker 1>repair of tissues. Yes. And then there's this quote speaking generally,

0:40:40.600 --> 0:40:44.239
<v Speaker 1>the longest lived things occur among the plants, example of

0:40:44.239 --> 0:40:47.000
<v Speaker 1>the date palm. Next, in order we find them among

0:40:47.160 --> 0:40:50.640
<v Speaker 1>the sanguineous animals rather than among the bloodless, and among

0:40:50.719 --> 0:40:55.000
<v Speaker 1>those with feet rather than among the denizens of the water. Hints.

0:40:55.120 --> 0:40:58.680
<v Speaker 1>Taking these two characters together, the longest lived animals fall

0:40:58.719 --> 0:41:03.279
<v Speaker 1>amongst sanguineous animals which have feet. Uh, men and elephants. Well,

0:41:03.320 --> 0:41:07.200
<v Speaker 1>clearly we've learned how to make your aquarium fish live longer.

0:41:07.520 --> 0:41:11.520
<v Speaker 1>You transplant some feet onto them. Uh, this at least

0:41:11.520 --> 0:41:13.520
<v Speaker 1>as good quote. As a matter of fact, also, it

0:41:13.640 --> 0:41:16.719
<v Speaker 1>is a general rule that the larger live longer than

0:41:16.719 --> 0:41:20.960
<v Speaker 1>the smaller. For the other long lived animals to happen

0:41:21.000 --> 0:41:24.040
<v Speaker 1>to be of a large size are also those I

0:41:24.080 --> 0:41:27.719
<v Speaker 1>have mentioned. Now, I'm sure this is not a hard

0:41:27.800 --> 0:41:30.000
<v Speaker 1>and fast rule, though I think there are probably some

0:41:30.120 --> 0:41:33.240
<v Speaker 1>weak correlations along these lines. So, I mean, we already

0:41:33.239 --> 0:41:36.080
<v Speaker 1>touched on the dinosaur thing. But but certainly there are

0:41:36.080 --> 0:41:40.680
<v Speaker 1>some examples of rather large animals that have longer lifespans

0:41:41.160 --> 0:41:45.520
<v Speaker 1>within typical longevity. Now Aristotle's working theory, though, is that

0:41:45.600 --> 0:41:50.080
<v Speaker 1>all of it revolves around moisture in an organism. Yes, quote,

0:41:50.120 --> 0:41:52.720
<v Speaker 1>we must remember that an animal is by nature human

0:41:52.719 --> 0:41:55.160
<v Speaker 1>and warm, and to live is to be of such

0:41:55.200 --> 0:41:58.480
<v Speaker 1>a constitution, while old age is dry and cold, and

0:41:58.520 --> 0:42:01.759
<v Speaker 1>so is a corpse. I think Aristotle also tried to

0:42:02.560 --> 0:42:08.520
<v Speaker 1>explain earthquakes by way of moisture, maybe misremembering that. And

0:42:08.719 --> 0:42:11.359
<v Speaker 1>he also said that aquatic animals don't count here because

0:42:11.400 --> 0:42:14.960
<v Speaker 1>they're not humid. Their watery and quote watery moisture is

0:42:15.000 --> 0:42:19.440
<v Speaker 1>easily destroyed since it is cold and readily congealed. And finally,

0:42:19.440 --> 0:42:21.879
<v Speaker 1>he also throws in four in animals, the males are

0:42:21.920 --> 0:42:25.279
<v Speaker 1>in general the longer lived. I don't think that's true either. Yeah,

0:42:25.320 --> 0:42:27.719
<v Speaker 1>I believe in in in in many cases it is

0:42:27.760 --> 0:42:30.920
<v Speaker 1>the It is the female that lives longer, certainly in humans,

0:42:31.640 --> 0:42:35.799
<v Speaker 1>though that may be more pronounced in cases where we

0:42:35.920 --> 0:42:39.040
<v Speaker 1>have been removed from the like when we've got modern

0:42:39.120 --> 0:42:41.920
<v Speaker 1>medical care, because, for example, there is a lot of

0:42:42.000 --> 0:42:48.400
<v Speaker 1>natural mortality during childbearing. Correct. So I don't know, you

0:42:48.400 --> 0:42:50.919
<v Speaker 1>can maybe a point for Aristotle. There maybe a point

0:42:51.000 --> 0:42:55.759
<v Speaker 1>for modern science. We'll see, um. But anyway, that's that's

0:42:55.960 --> 0:42:58.200
<v Speaker 1>that's what Aristotle had to say in the matter. And uh,

0:42:58.840 --> 0:43:01.920
<v Speaker 1>and I like, I say, it's it's it's fascinating to

0:43:01.960 --> 0:43:03.919
<v Speaker 1>look back on his writings and see how he's working

0:43:03.960 --> 0:43:06.560
<v Speaker 1>this all out totally. So in the end, I think

0:43:06.600 --> 0:43:11.839
<v Speaker 1>we're still left with this biological paradox of aging. Once

0:43:11.840 --> 0:43:14.640
<v Speaker 1>we think about aging in a biological context, it's sort

0:43:14.680 --> 0:43:19.040
<v Speaker 1>of fails to make sense. Evolution selects for genes that

0:43:19.200 --> 0:43:23.360
<v Speaker 1>increase biological fitness, meaning that increase the chances of survival

0:43:23.480 --> 0:43:28.759
<v Speaker 1>and reproduction. Aging is characterized by an organism level decline

0:43:29.160 --> 0:43:33.560
<v Speaker 1>in the chances of survival and reproduction. So why would

0:43:33.640 --> 0:43:38.880
<v Speaker 1>organisms that have been evolving for billions of years still age, deteriorate,

0:43:39.239 --> 0:43:43.200
<v Speaker 1>lose the ability to reproduce, and eventually die. Shouldn't we

0:43:43.239 --> 0:43:48.320
<v Speaker 1>have evolved to maximize survival and reproduction as long as possible.

0:43:48.400 --> 0:43:52.120
<v Speaker 1>Shouldn't we survive and keep making babies until a leopard

0:43:52.120 --> 0:43:54.680
<v Speaker 1>bites our head off? But obviously this is not how

0:43:54.719 --> 0:43:57.879
<v Speaker 1>things are. So what's the answer to this mystery? Will

0:43:57.880 --> 0:44:00.319
<v Speaker 1>explore that in the next episode. As right, we have

0:44:00.320 --> 0:44:05.399
<v Speaker 1>a cliffhanger. Will it be cruel twist of fate? Accident? Uh,

0:44:05.680 --> 0:44:09.399
<v Speaker 1>biological mechanism that serves a purpose? I don't know. We'll

0:44:09.400 --> 0:44:12.600
<v Speaker 1>find out maybe our genome has been evolving to feed

0:44:12.640 --> 0:44:16.879
<v Speaker 1>leopards all right. Well, in the meantime, while you're waiting

0:44:16.880 --> 0:44:18.880
<v Speaker 1>for that next episode, head on over to Stuff to

0:44:18.920 --> 0:44:21.200
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