WEBVTT - UCF's Dr. Khaled on Delivering 'Cure' to Cancer Cells (Audio)

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<v Speaker 1>Eleven three oh Global business news twenty four hours a

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<v Speaker 1>from Bloomberg World Headquarters. I'm Charlie Pellett. Stocks are advancing

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<v Speaker 1>I'm Charlie Pelleton. That's a bloom Bred business flash. You're

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<v Speaker 1>listening to taking stock with on Bluebird Radio. Were are

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<v Speaker 1>broadcasting live at Pershing's Inside Twenties sixteen conference at the

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<v Speaker 1>Higher Regency in Orlando of Florida. And you know, planning

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<v Speaker 1>for retirement means more than just having a personal plan

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<v Speaker 1>to assure that you have enough money to enjoy your

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<v Speaker 1>older age. It's also about having a health plan and

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<v Speaker 1>being healthy in order to enjoy it. Here to tell

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<v Speaker 1>us more is Dr Annette Khalid, Cancer Division Head and

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<v Speaker 1>Associate Professor at the Burnett School of Biomedical Sciences, University

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<v Speaker 1>of Central Florida College of Medicine. Dr Khaleen, thank you

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<v Speaker 1>very much for being here. Now. I know that you

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<v Speaker 1>spoke on the panel having to do with developing the

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<v Speaker 1>next generation of treatments for cancer. I wonder if you

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<v Speaker 1>could just speak a little bit about why this is

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<v Speaker 1>such a crucial issue for all of the attendees here

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<v Speaker 1>at this Pershing conference. So we're really at a or

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<v Speaker 1>front right now and cancer research where we're making discoveries

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<v Speaker 1>that are going to advanced cures for patients. But we've

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<v Speaker 1>discovered that in order to personalize cure for a specific

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<v Speaker 1>patients tumor, we had a lot more treatments that we

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<v Speaker 1>have currently available. In fact, only about maybe two to

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<v Speaker 1>three percent of patients actually have a type of tumor

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<v Speaker 1>that can be treated with currently available drugs. We need

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<v Speaker 1>a lot more drugs in the marketplace, and that's what

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<v Speaker 1>labs like mine are doing, is we're discovering new drugs

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<v Speaker 1>and trying to move them forward to commercialize them and

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<v Speaker 1>get them into patients. That is stunning though, to say

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<v Speaker 1>such a small amount of tumors are really only truly

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<v Speaker 1>treatable with the current the current drugs, the current protocols

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<v Speaker 1>you are on in the midst of something that's very important,

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<v Speaker 1>because to cure cancer seems like the big thing is

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<v Speaker 1>to figure out how it works and and get in

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<v Speaker 1>the middle of that process so the cancer cannot develop, right,

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<v Speaker 1>So talk to us about c T twenty P. It's

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<v Speaker 1>a molecule that gets in the way of something called

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<v Speaker 1>a chaperone in which is a key part of a

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<v Speaker 1>tumor growing and developing and ultimately killing someone if you

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<v Speaker 1>can't stop it. So you can, you've defined our platform

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<v Speaker 1>very well. We actually discovered a therapeutic that is a

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<v Speaker 1>small peptide that's really made of amino acids that are

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<v Speaker 1>part of your bodies, you know, normal cells, and this

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<v Speaker 1>peptide actually goes to cancer cells and specifically kills them.

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<v Speaker 1>And the way it does it is because it interferes

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<v Speaker 1>with very large machinery. It's also found in cells. It's

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<v Speaker 1>called the chaperonein, and what chaperones do is they basically

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<v Speaker 1>fold proteins in their final shapes so they can function.

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<v Speaker 1>You know, d NA makes rna, RNA makes protein, but

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<v Speaker 1>proteins don't stop. Their proteins have to have an activity,

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<v Speaker 1>but they have to have the right shape to be

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<v Speaker 1>able to have their activities. And that's what chaperoneins do.

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<v Speaker 1>They actually make proteins reach the right shape so they

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<v Speaker 1>can function and do their jobs. So cancer cells need

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<v Speaker 1>a lot of proteins and they need a lot of

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<v Speaker 1>proteins in the right shape. And so our pep tide

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<v Speaker 1>blocks the shaperone and specifically in cancer cells and thereby

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<v Speaker 1>reducing the number of proteins that confunction and cancer cells

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<v Speaker 1>and cancer cells will then die. Dr Khalid maybe explain

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<v Speaker 1>the kind of cancer that we're talking about here, because

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<v Speaker 1>I understand that if you have cancer or tumor in

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<v Speaker 1>one part of your body and then it metastasized, it

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<v Speaker 1>shifts to other parts of your body. Now we're getting

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<v Speaker 1>into an area where you can imagine people need a

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<v Speaker 1>lot of help to just correct correct. So so usually

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<v Speaker 1>the tumors localized or it's a primary tumor, a lot

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<v Speaker 1>of treatments might be able to you know, surgeries or

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<v Speaker 1>even you know, toxic compounds, chemotherapeutics, radiation can really deal

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<v Speaker 1>with the localized tumors. It's when these tumors, as you mentioned,

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<v Speaker 1>leave that primary location when they spread. They spread and

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<v Speaker 1>they moved to the brain, when they moved to the

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<v Speaker 1>lungs or the bones areas, they're really hard to treat

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<v Speaker 1>and really hard to find, and so it's a challenge

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<v Speaker 1>to find the treatments drugs that will actually help these

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<v Speaker 1>patients eliminate the spread. And what we do with our

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<v Speaker 1>treatment is actually target those cells specifically, we're targeting these

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<v Speaker 1>cells that rove around and preventing them from basically moving.

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<v Speaker 1>A lot of your work right now focusing on breast cancer.

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<v Speaker 1>Correct We're using breast cancer is our model because it

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<v Speaker 1>really affects so many women and it's really a challenge

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<v Speaker 1>because when it metaticizes, there's very little choices out there.

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<v Speaker 1>What about raising money to do exactly exactly so that's

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<v Speaker 1>that's the challenge that we have. So you know where

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<v Speaker 1>our ideas are very vulnerable because we don't have funding

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<v Speaker 1>to see them through. And this is where we need funds.

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<v Speaker 1>We need organizations like the Breast Cancer Research Foundation that

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<v Speaker 1>funds studies like mine to be able to develop these

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<v Speaker 1>ideas that we have into something that can be turned

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<v Speaker 1>into a cancer drug for patients. Tell us a bit

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<v Speaker 1>about and I'm sure one of the reasons is that

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<v Speaker 1>you need money. And let's just underscore this that Dr

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<v Speaker 1>Nekhalid is that the Burnett's School of Biomedical Sciences. And again,

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<v Speaker 1>if you want to send some money or help our

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<v Speaker 1>research co right ahead, yes, please, yes, because we're what

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<v Speaker 1>we're doing is not only helping cancer, you know, survivors,

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<v Speaker 1>preventing cancer, um menistetic cancer is not just breast cancer.

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<v Speaker 1>There's so many cancers that you know, prostate, long liver,

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<v Speaker 1>all these ministhetic sites. What we do can help those

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<v Speaker 1>cancers as well. I just said that one the reason

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<v Speaker 1>it's probably costly. You're using you know, you're harnessing nanotechnology

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<v Speaker 1>for example. Tell us about some of the tools that

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<v Speaker 1>are that you're developing and using to do this groundbreaking

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<v Speaker 1>cancer search and discovery. Correct. So as we have a

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<v Speaker 1>drug and we have a target, we have to get

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<v Speaker 1>our drug to that target. And that's where now technology

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<v Speaker 1>comes in. We can use these small nanoparticles and they're

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<v Speaker 1>actually made of a polyester polymer. It's biodegradable, and we

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<v Speaker 1>can load up these little nanoparticles with our PEP tide

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<v Speaker 1>injected into you know, a patient, and have those nanta

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<v Speaker 1>particles find the tumors and deliver our pep tide to

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<v Speaker 1>those tumors. I wonder if you can describe also the

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<v Speaker 1>idea of finding the right doctor or the right treatment.

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<v Speaker 1>How does a patient go about doing this? Because it

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<v Speaker 1>seems as though you could go online, but you could

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<v Speaker 1>also end up in a place that is not necessarily

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<v Speaker 1>going to give you stuff that's useful. You've actually hit

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<v Speaker 1>a real problem in the field because you can have

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<v Speaker 1>a lot of clinical trials and academic centers, but there

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<v Speaker 1>are very few academic centers are accessible to all the patients.

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<v Speaker 1>If you live in you know, a major city, find

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<v Speaker 1>But what if you don't, how do you find these

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<v Speaker 1>these treatments, these clinics. Your own doctor is still the

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<v Speaker 1>best place to start with. But you know, we have

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<v Speaker 1>to fix that. We have to make these clinical trials

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<v Speaker 1>and these things in a way that's accessible to patients,

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<v Speaker 1>not just you know, those patients that happen to live

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<v Speaker 1>in an academic area. I'm still forging of those little

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<v Speaker 1>polyous and your polymers who are grabbing the peptides and

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<v Speaker 1>moving them around. It just it's just it's so it's

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<v Speaker 1>fascinating U as far as very top down, we're in

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<v Speaker 1>election year. If you were suddenly the czar of of

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<v Speaker 1>on BAT team finding a cure for cancer, what would

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<v Speaker 1>you say about the big system we have in place

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<v Speaker 1>that needs to be changed. It needs to move forward.

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<v Speaker 1>You're obviously mentioning money. Well, key is money. So first

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<v Speaker 1>we need to put more money into these ideas. There

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<v Speaker 1>there are thousands and thousands and thousands of scientists working

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<v Speaker 1>on cures. We need money to move forward so we

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<v Speaker 1>can develop our cures into break twos that can be

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<v Speaker 1>developed in technologies. But more importantly, once we've got the

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<v Speaker 1>technology in hand, we need to facilitate the process of

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<v Speaker 1>getting through you know, intellectual property. The patent process takes

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<v Speaker 1>way too long. I mean, waiting around for five years

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<v Speaker 1>to get a patent issue it so you can commercialize

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<v Speaker 1>your technology. That's way too much time to waste. We

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<v Speaker 1>need to work with FDA to get things to happen faster,

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<v Speaker 1>so we're not spending you know, eight to ten years

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<v Speaker 1>waiting through all the clinical trials and everything to get

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<v Speaker 1>to that point. So there's a lot of things that

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<v Speaker 1>have to work handaha with government, with regulatory agencies to

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<v Speaker 1>make things happen for the scientists who are developing new technologies.

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<v Speaker 1>These new technologies primarily being developed in the United States,

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<v Speaker 1>now all over the world. The United States is definitely

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<v Speaker 1>a leader. You know, over fifty of our universities are

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<v Speaker 1>working on basic science research that will lead to new

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<v Speaker 1>discoveries education. You've been on this road for some time obviously,

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<v Speaker 1>so much hard work to get to the level where

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<v Speaker 1>you are. If you're if you're advising some young person

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<v Speaker 1>about going into this field as a doctor, a scientist,

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<v Speaker 1>someone who is working on the technology or even selling,

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<v Speaker 1>I mean, what what advice would you give them at

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<v Speaker 1>this point? Is this a growing field? This is a

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<v Speaker 1>tough field. It's a tough field. But you follow your heart.

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<v Speaker 1>That's what I tell everybody. You love what you do.

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<v Speaker 1>You have to absolutely have a passion for what you

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<v Speaker 1>do and if you have have that, you'll be successful.

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<v Speaker 1>So I trained students in my lab, and I've got

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<v Speaker 1>students who work in by a technology technology transfer who

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<v Speaker 1>are doing academic like I'm doing myself. So I've trained

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<v Speaker 1>students who do all sorts of different things with their degrees.

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<v Speaker 1>Just follow your passion, follow your hearts, what I tell them.

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<v Speaker 1>We are in Florida, so I do want to ask

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<v Speaker 1>you a little bit about melanoma and carcinoma. You've got

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<v Speaker 1>to because this is, you know, it seems like something

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<v Speaker 1>that only you avoid when you're you know, young and

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<v Speaker 1>and and healthy, but it can come back and hurt

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<v Speaker 1>you later later on. What kind of advances or what

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<v Speaker 1>kind of treatments are are currently being worked on. Some

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<v Speaker 1>great immunotherapy is coming out there, teaching your body to

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<v Speaker 1>you know, function and kill the cancers themselves, enabling your

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<v Speaker 1>your body to defend yourself. And of course where your

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<v Speaker 1>sun screen and where your hat if you're in Florida.

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<v Speaker 1>It sounds like a good idea. I want to thank

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<v Speaker 1>you very much for spending time with us. Dr Annette

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<v Speaker 1>Khali is the ahead of the Cancer Division and Associate

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<v Speaker 1>professor the Burnett School of Biomedical Sciences at the University

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<v Speaker 1>of Central Florida College of Medicine. You're listening to Taking

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<v Speaker 1>Stockh'm PIM Fox my co host Kathleen Hayes. We are

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<v Speaker 1>broadcasting live at Persian's Inside Conference at the Hyatt Agency

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<v Speaker 1>in Orlando. This year marks eighteen years of insight, eighteen

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<v Speaker 1>years committed to the success of advisors. Were here with

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<v Speaker 1>over two thousand financial professionals from all over the globe.

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<v Speaker 1>And you're listening to the Bloomberg Radio