1 00:00:00,120 --> 00:00:05,640 Speaker 1: Eleven three oh Global business news twenty four hours a 2 00:00:05,760 --> 00:00:08,959 Speaker 1: day at Bloomberg dot com, the radio plus mobile LAPP 3 00:00:09,039 --> 00:00:12,280 Speaker 1: and on your radio. This is a Bloomberg Business flag 4 00:00:12,360 --> 00:00:16,640 Speaker 1: from Bloomberg World Headquarters. I'm Charlie Pellett. Stocks are advancing 5 00:00:16,720 --> 00:00:20,400 Speaker 1: the SMP five hundred index within one percent of its record. 6 00:00:20,520 --> 00:00:25,080 Speaker 1: Rallies and energy producers and airlines offsetting slumping healthcare shares. 7 00:00:25,160 --> 00:00:28,400 Speaker 1: Right now, the SMP at seventeen the record on the 8 00:00:28,480 --> 00:00:32,960 Speaker 1: SMP twenty one thirty reached last May. Right now, the 9 00:00:33,080 --> 00:00:35,440 Speaker 1: SMP of four tenths of one percent to Dow also 10 00:00:35,560 --> 00:00:38,040 Speaker 1: hired by four tenths of one percent, up seventy points 11 00:00:38,280 --> 00:00:41,519 Speaker 1: to seventeen thousand, nine hundred ninety has stand up for 12 00:00:41,760 --> 00:00:44,720 Speaker 1: a gain of point one percent. Ten You're up eight 13 00:00:44,800 --> 00:00:48,840 Speaker 1: thirty seconds yield one point seven oh percent. Gold unchanged 14 00:00:48,880 --> 00:00:52,840 Speaker 1: at twelve forty seven fifty crude trading above fifty dollars 15 00:00:52,880 --> 00:00:55,360 Speaker 1: of barrel fifty forty two. Right now on West Texas 16 00:00:55,440 --> 00:00:58,320 Speaker 1: Intermediate it is up by one and a half percent. 17 00:00:58,760 --> 00:01:03,760 Speaker 1: I'm Charlie Pelleton. That's a bloom Bred business flash. You're 18 00:01:03,800 --> 00:01:09,280 Speaker 1: listening to taking stock with on Bluebird Radio. Were are 19 00:01:09,280 --> 00:01:13,320 Speaker 1: broadcasting live at Pershing's Inside Twenties sixteen conference at the 20 00:01:13,400 --> 00:01:16,520 Speaker 1: Higher Regency in Orlando of Florida. And you know, planning 21 00:01:16,520 --> 00:01:20,160 Speaker 1: for retirement means more than just having a personal plan 22 00:01:20,600 --> 00:01:23,360 Speaker 1: to assure that you have enough money to enjoy your 23 00:01:23,400 --> 00:01:26,679 Speaker 1: older age. It's also about having a health plan and 24 00:01:26,840 --> 00:01:28,959 Speaker 1: being healthy in order to enjoy it. Here to tell 25 00:01:29,040 --> 00:01:32,640 Speaker 1: us more is Dr Annette Khalid, Cancer Division Head and 26 00:01:32,680 --> 00:01:36,919 Speaker 1: Associate Professor at the Burnett School of Biomedical Sciences, University 27 00:01:37,000 --> 00:01:41,039 Speaker 1: of Central Florida College of Medicine. Dr Khaleen, thank you 28 00:01:41,120 --> 00:01:43,520 Speaker 1: very much for being here. Now. I know that you 29 00:01:43,640 --> 00:01:46,040 Speaker 1: spoke on the panel having to do with developing the 30 00:01:46,080 --> 00:01:50,120 Speaker 1: next generation of treatments for cancer. I wonder if you 31 00:01:50,120 --> 00:01:52,760 Speaker 1: could just speak a little bit about why this is 32 00:01:52,800 --> 00:01:56,200 Speaker 1: such a crucial issue for all of the attendees here 33 00:01:56,240 --> 00:02:00,160 Speaker 1: at this Pershing conference. So we're really at a or 34 00:02:00,240 --> 00:02:03,680 Speaker 1: front right now and cancer research where we're making discoveries 35 00:02:03,720 --> 00:02:06,440 Speaker 1: that are going to advanced cures for patients. But we've 36 00:02:06,480 --> 00:02:10,239 Speaker 1: discovered that in order to personalize cure for a specific 37 00:02:10,280 --> 00:02:13,160 Speaker 1: patients tumor, we had a lot more treatments that we 38 00:02:13,160 --> 00:02:16,560 Speaker 1: have currently available. In fact, only about maybe two to 39 00:02:16,639 --> 00:02:19,799 Speaker 1: three percent of patients actually have a type of tumor 40 00:02:19,840 --> 00:02:22,960 Speaker 1: that can be treated with currently available drugs. We need 41 00:02:23,000 --> 00:02:25,680 Speaker 1: a lot more drugs in the marketplace, and that's what 42 00:02:25,760 --> 00:02:28,320 Speaker 1: labs like mine are doing, is we're discovering new drugs 43 00:02:28,400 --> 00:02:31,000 Speaker 1: and trying to move them forward to commercialize them and 44 00:02:31,040 --> 00:02:33,639 Speaker 1: get them into patients. That is stunning though, to say 45 00:02:33,639 --> 00:02:37,360 Speaker 1: such a small amount of tumors are really only truly 46 00:02:37,480 --> 00:02:43,200 Speaker 1: treatable with the current the current drugs, the current protocols 47 00:02:43,960 --> 00:02:47,359 Speaker 1: you are on in the midst of something that's very important, 48 00:02:47,880 --> 00:02:50,840 Speaker 1: because to cure cancer seems like the big thing is 49 00:02:50,880 --> 00:02:52,400 Speaker 1: to figure out how it works and and get in 50 00:02:52,440 --> 00:02:55,399 Speaker 1: the middle of that process so the cancer cannot develop, right, 51 00:02:55,520 --> 00:03:00,720 Speaker 1: So talk to us about c T twenty P. It's 52 00:03:00,720 --> 00:03:04,760 Speaker 1: a molecule that gets in the way of something called 53 00:03:04,880 --> 00:03:08,000 Speaker 1: a chaperone in which is a key part of a 54 00:03:08,080 --> 00:03:10,720 Speaker 1: tumor growing and developing and ultimately killing someone if you 55 00:03:10,760 --> 00:03:13,960 Speaker 1: can't stop it. So you can, you've defined our platform 56 00:03:14,160 --> 00:03:17,400 Speaker 1: very well. We actually discovered a therapeutic that is a 57 00:03:17,480 --> 00:03:20,200 Speaker 1: small peptide that's really made of amino acids that are 58 00:03:20,240 --> 00:03:23,160 Speaker 1: part of your bodies, you know, normal cells, and this 59 00:03:23,200 --> 00:03:26,920 Speaker 1: peptide actually goes to cancer cells and specifically kills them. 60 00:03:26,960 --> 00:03:29,200 Speaker 1: And the way it does it is because it interferes 61 00:03:29,240 --> 00:03:32,600 Speaker 1: with very large machinery. It's also found in cells. It's 62 00:03:32,639 --> 00:03:35,920 Speaker 1: called the chaperonein, and what chaperones do is they basically 63 00:03:36,000 --> 00:03:39,080 Speaker 1: fold proteins in their final shapes so they can function. 64 00:03:39,520 --> 00:03:42,600 Speaker 1: You know, d NA makes rna, RNA makes protein, but 65 00:03:42,680 --> 00:03:45,720 Speaker 1: proteins don't stop. Their proteins have to have an activity, 66 00:03:45,760 --> 00:03:48,080 Speaker 1: but they have to have the right shape to be 67 00:03:48,160 --> 00:03:51,120 Speaker 1: able to have their activities. And that's what chaperoneins do. 68 00:03:51,280 --> 00:03:54,520 Speaker 1: They actually make proteins reach the right shape so they 69 00:03:54,560 --> 00:03:58,200 Speaker 1: can function and do their jobs. So cancer cells need 70 00:03:58,240 --> 00:04:00,080 Speaker 1: a lot of proteins and they need a lot of 71 00:04:00,160 --> 00:04:02,880 Speaker 1: proteins in the right shape. And so our pep tide 72 00:04:02,920 --> 00:04:07,200 Speaker 1: blocks the shaperone and specifically in cancer cells and thereby 73 00:04:07,240 --> 00:04:10,920 Speaker 1: reducing the number of proteins that confunction and cancer cells 74 00:04:11,040 --> 00:04:15,240 Speaker 1: and cancer cells will then die. Dr Khalid maybe explain 75 00:04:15,760 --> 00:04:19,039 Speaker 1: the kind of cancer that we're talking about here, because 76 00:04:19,080 --> 00:04:22,000 Speaker 1: I understand that if you have cancer or tumor in 77 00:04:22,080 --> 00:04:24,640 Speaker 1: one part of your body and then it metastasized, it 78 00:04:24,720 --> 00:04:27,679 Speaker 1: shifts to other parts of your body. Now we're getting 79 00:04:27,680 --> 00:04:31,320 Speaker 1: into an area where you can imagine people need a 80 00:04:31,320 --> 00:04:34,200 Speaker 1: lot of help to just correct correct. So so usually 81 00:04:34,320 --> 00:04:37,840 Speaker 1: the tumors localized or it's a primary tumor, a lot 82 00:04:37,880 --> 00:04:40,400 Speaker 1: of treatments might be able to you know, surgeries or 83 00:04:40,400 --> 00:04:44,560 Speaker 1: even you know, toxic compounds, chemotherapeutics, radiation can really deal 84 00:04:44,600 --> 00:04:48,040 Speaker 1: with the localized tumors. It's when these tumors, as you mentioned, 85 00:04:48,120 --> 00:04:51,000 Speaker 1: leave that primary location when they spread. They spread and 86 00:04:51,000 --> 00:04:52,919 Speaker 1: they moved to the brain, when they moved to the 87 00:04:53,040 --> 00:04:56,400 Speaker 1: lungs or the bones areas, they're really hard to treat 88 00:04:56,520 --> 00:04:58,960 Speaker 1: and really hard to find, and so it's a challenge 89 00:04:59,000 --> 00:05:01,640 Speaker 1: to find the treatments drugs that will actually help these 90 00:05:01,640 --> 00:05:05,280 Speaker 1: patients eliminate the spread. And what we do with our 91 00:05:05,320 --> 00:05:08,920 Speaker 1: treatment is actually target those cells specifically, we're targeting these 92 00:05:08,920 --> 00:05:12,240 Speaker 1: cells that rove around and preventing them from basically moving. 93 00:05:12,480 --> 00:05:14,640 Speaker 1: A lot of your work right now focusing on breast cancer. 94 00:05:14,839 --> 00:05:17,960 Speaker 1: Correct We're using breast cancer is our model because it 95 00:05:18,120 --> 00:05:21,200 Speaker 1: really affects so many women and it's really a challenge 96 00:05:21,240 --> 00:05:24,120 Speaker 1: because when it metaticizes, there's very little choices out there. 97 00:05:24,880 --> 00:05:28,880 Speaker 1: What about raising money to do exactly exactly so that's 98 00:05:28,920 --> 00:05:31,440 Speaker 1: that's the challenge that we have. So you know where 99 00:05:31,520 --> 00:05:34,560 Speaker 1: our ideas are very vulnerable because we don't have funding 100 00:05:34,600 --> 00:05:37,240 Speaker 1: to see them through. And this is where we need funds. 101 00:05:37,240 --> 00:05:40,600 Speaker 1: We need organizations like the Breast Cancer Research Foundation that 102 00:05:41,120 --> 00:05:44,000 Speaker 1: funds studies like mine to be able to develop these 103 00:05:44,040 --> 00:05:46,240 Speaker 1: ideas that we have into something that can be turned 104 00:05:46,240 --> 00:05:48,600 Speaker 1: into a cancer drug for patients. Tell us a bit 105 00:05:48,680 --> 00:05:50,560 Speaker 1: about and I'm sure one of the reasons is that 106 00:05:50,600 --> 00:05:53,840 Speaker 1: you need money. And let's just underscore this that Dr 107 00:05:53,960 --> 00:05:59,080 Speaker 1: Nekhalid is that the Burnett's School of Biomedical Sciences. And again, 108 00:05:59,120 --> 00:06:01,560 Speaker 1: if you want to send some money or help our 109 00:06:01,560 --> 00:06:04,560 Speaker 1: research co right ahead, yes, please, yes, because we're what 110 00:06:04,600 --> 00:06:07,560 Speaker 1: we're doing is not only helping cancer, you know, survivors, 111 00:06:07,640 --> 00:06:11,440 Speaker 1: preventing cancer, um menistetic cancer is not just breast cancer. 112 00:06:11,480 --> 00:06:15,160 Speaker 1: There's so many cancers that you know, prostate, long liver, 113 00:06:15,279 --> 00:06:18,560 Speaker 1: all these ministhetic sites. What we do can help those 114 00:06:18,600 --> 00:06:20,680 Speaker 1: cancers as well. I just said that one the reason 115 00:06:20,720 --> 00:06:25,200 Speaker 1: it's probably costly. You're using you know, you're harnessing nanotechnology 116 00:06:25,360 --> 00:06:27,880 Speaker 1: for example. Tell us about some of the tools that 117 00:06:27,920 --> 00:06:31,000 Speaker 1: are that you're developing and using to do this groundbreaking 118 00:06:31,040 --> 00:06:34,359 Speaker 1: cancer search and discovery. Correct. So as we have a 119 00:06:34,440 --> 00:06:36,640 Speaker 1: drug and we have a target, we have to get 120 00:06:36,640 --> 00:06:39,719 Speaker 1: our drug to that target. And that's where now technology 121 00:06:39,760 --> 00:06:42,920 Speaker 1: comes in. We can use these small nanoparticles and they're 122 00:06:42,920 --> 00:06:46,760 Speaker 1: actually made of a polyester polymer. It's biodegradable, and we 123 00:06:46,800 --> 00:06:49,520 Speaker 1: can load up these little nanoparticles with our PEP tide 124 00:06:50,040 --> 00:06:53,120 Speaker 1: injected into you know, a patient, and have those nanta 125 00:06:53,160 --> 00:06:55,640 Speaker 1: particles find the tumors and deliver our pep tide to 126 00:06:55,680 --> 00:06:59,400 Speaker 1: those tumors. I wonder if you can describe also the 127 00:06:59,480 --> 00:07:02,799 Speaker 1: idea of finding the right doctor or the right treatment. 128 00:07:02,880 --> 00:07:06,279 Speaker 1: How does a patient go about doing this? Because it 129 00:07:06,279 --> 00:07:09,360 Speaker 1: seems as though you could go online, but you could 130 00:07:09,360 --> 00:07:12,200 Speaker 1: also end up in a place that is not necessarily 131 00:07:12,200 --> 00:07:15,000 Speaker 1: going to give you stuff that's useful. You've actually hit 132 00:07:15,080 --> 00:07:18,600 Speaker 1: a real problem in the field because you can have 133 00:07:18,880 --> 00:07:21,720 Speaker 1: a lot of clinical trials and academic centers, but there 134 00:07:21,760 --> 00:07:24,680 Speaker 1: are very few academic centers are accessible to all the patients. 135 00:07:25,000 --> 00:07:27,160 Speaker 1: If you live in you know, a major city, find 136 00:07:27,200 --> 00:07:29,240 Speaker 1: But what if you don't, how do you find these 137 00:07:29,280 --> 00:07:32,400 Speaker 1: these treatments, these clinics. Your own doctor is still the 138 00:07:32,440 --> 00:07:35,120 Speaker 1: best place to start with. But you know, we have 139 00:07:35,280 --> 00:07:37,560 Speaker 1: to fix that. We have to make these clinical trials 140 00:07:37,560 --> 00:07:40,240 Speaker 1: and these things in a way that's accessible to patients, 141 00:07:40,280 --> 00:07:42,400 Speaker 1: not just you know, those patients that happen to live 142 00:07:42,440 --> 00:07:44,880 Speaker 1: in an academic area. I'm still forging of those little 143 00:07:44,920 --> 00:07:47,640 Speaker 1: polyous and your polymers who are grabbing the peptides and 144 00:07:47,680 --> 00:07:50,200 Speaker 1: moving them around. It just it's just it's so it's 145 00:07:50,240 --> 00:07:55,240 Speaker 1: fascinating U as far as very top down, we're in 146 00:07:55,360 --> 00:07:59,520 Speaker 1: election year. If you were suddenly the czar of of 147 00:08:00,000 --> 00:08:03,400 Speaker 1: on BAT team finding a cure for cancer, what would 148 00:08:03,400 --> 00:08:06,600 Speaker 1: you say about the big system we have in place 149 00:08:06,880 --> 00:08:09,320 Speaker 1: that needs to be changed. It needs to move forward. 150 00:08:09,360 --> 00:08:13,239 Speaker 1: You're obviously mentioning money. Well, key is money. So first 151 00:08:13,240 --> 00:08:16,280 Speaker 1: we need to put more money into these ideas. There 152 00:08:16,320 --> 00:08:19,280 Speaker 1: there are thousands and thousands and thousands of scientists working 153 00:08:19,400 --> 00:08:22,480 Speaker 1: on cures. We need money to move forward so we 154 00:08:22,480 --> 00:08:25,080 Speaker 1: can develop our cures into break twos that can be 155 00:08:25,280 --> 00:08:28,880 Speaker 1: developed in technologies. But more importantly, once we've got the 156 00:08:29,000 --> 00:08:32,520 Speaker 1: technology in hand, we need to facilitate the process of 157 00:08:32,559 --> 00:08:36,880 Speaker 1: getting through you know, intellectual property. The patent process takes 158 00:08:36,960 --> 00:08:39,720 Speaker 1: way too long. I mean, waiting around for five years 159 00:08:39,920 --> 00:08:42,200 Speaker 1: to get a patent issue it so you can commercialize 160 00:08:42,200 --> 00:08:45,600 Speaker 1: your technology. That's way too much time to waste. We 161 00:08:45,679 --> 00:08:48,280 Speaker 1: need to work with FDA to get things to happen faster, 162 00:08:48,360 --> 00:08:50,640 Speaker 1: so we're not spending you know, eight to ten years 163 00:08:50,640 --> 00:08:52,839 Speaker 1: waiting through all the clinical trials and everything to get 164 00:08:52,880 --> 00:08:54,880 Speaker 1: to that point. So there's a lot of things that 165 00:08:54,960 --> 00:08:58,800 Speaker 1: have to work handaha with government, with regulatory agencies to 166 00:08:58,920 --> 00:09:02,319 Speaker 1: make things happen for the scientists who are developing new technologies. 167 00:09:02,840 --> 00:09:06,240 Speaker 1: These new technologies primarily being developed in the United States, 168 00:09:06,720 --> 00:09:09,240 Speaker 1: now all over the world. The United States is definitely 169 00:09:09,240 --> 00:09:12,640 Speaker 1: a leader. You know, over fifty of our universities are 170 00:09:12,679 --> 00:09:15,319 Speaker 1: working on basic science research that will lead to new 171 00:09:15,320 --> 00:09:22,040 Speaker 1: discoveries education. You've been on this road for some time obviously, 172 00:09:22,360 --> 00:09:24,280 Speaker 1: so much hard work to get to the level where 173 00:09:24,320 --> 00:09:28,320 Speaker 1: you are. If you're if you're advising some young person 174 00:09:28,360 --> 00:09:31,960 Speaker 1: about going into this field as a doctor, a scientist, 175 00:09:32,280 --> 00:09:35,920 Speaker 1: someone who is working on the technology or even selling, 176 00:09:36,000 --> 00:09:37,800 Speaker 1: I mean, what what advice would you give them at 177 00:09:37,800 --> 00:09:39,320 Speaker 1: this point? Is this a growing field? This is a 178 00:09:39,320 --> 00:09:41,720 Speaker 1: tough field. It's a tough field. But you follow your heart. 179 00:09:41,800 --> 00:09:43,800 Speaker 1: That's what I tell everybody. You love what you do. 180 00:09:44,000 --> 00:09:45,920 Speaker 1: You have to absolutely have a passion for what you 181 00:09:45,960 --> 00:09:48,640 Speaker 1: do and if you have have that, you'll be successful. 182 00:09:49,000 --> 00:09:50,800 Speaker 1: So I trained students in my lab, and I've got 183 00:09:50,840 --> 00:09:54,120 Speaker 1: students who work in by a technology technology transfer who 184 00:09:54,200 --> 00:09:57,480 Speaker 1: are doing academic like I'm doing myself. So I've trained 185 00:09:57,480 --> 00:09:59,880 Speaker 1: students who do all sorts of different things with their degrees. 186 00:10:00,240 --> 00:10:03,120 Speaker 1: Just follow your passion, follow your hearts, what I tell them. 187 00:10:03,160 --> 00:10:04,840 Speaker 1: We are in Florida, so I do want to ask 188 00:10:04,840 --> 00:10:09,240 Speaker 1: you a little bit about melanoma and carcinoma. You've got 189 00:10:09,240 --> 00:10:11,760 Speaker 1: to because this is, you know, it seems like something 190 00:10:11,760 --> 00:10:14,840 Speaker 1: that only you avoid when you're you know, young and 191 00:10:14,840 --> 00:10:17,280 Speaker 1: and and healthy, but it can come back and hurt 192 00:10:17,320 --> 00:10:19,920 Speaker 1: you later later on. What kind of advances or what 193 00:10:20,040 --> 00:10:22,720 Speaker 1: kind of treatments are are currently being worked on. Some 194 00:10:22,840 --> 00:10:26,240 Speaker 1: great immunotherapy is coming out there, teaching your body to 195 00:10:26,480 --> 00:10:30,000 Speaker 1: you know, function and kill the cancers themselves, enabling your 196 00:10:30,040 --> 00:10:32,640 Speaker 1: your body to defend yourself. And of course where your 197 00:10:32,640 --> 00:10:34,560 Speaker 1: sun screen and where your hat if you're in Florida. 198 00:10:35,120 --> 00:10:36,920 Speaker 1: It sounds like a good idea. I want to thank 199 00:10:36,920 --> 00:10:39,199 Speaker 1: you very much for spending time with us. Dr Annette 200 00:10:39,240 --> 00:10:42,719 Speaker 1: Khali is the ahead of the Cancer Division and Associate 201 00:10:42,720 --> 00:10:47,119 Speaker 1: professor the Burnett School of Biomedical Sciences at the University 202 00:10:47,200 --> 00:10:51,560 Speaker 1: of Central Florida College of Medicine. You're listening to Taking 203 00:10:51,600 --> 00:10:54,520 Speaker 1: Stockh'm PIM Fox my co host Kathleen Hayes. We are 204 00:10:54,520 --> 00:11:00,400 Speaker 1: broadcasting live at Persian's Inside Conference at the Hyatt Agency 205 00:11:00,400 --> 00:11:04,520 Speaker 1: in Orlando. This year marks eighteen years of insight, eighteen 206 00:11:04,600 --> 00:11:07,640 Speaker 1: years committed to the success of advisors. Were here with 207 00:11:07,679 --> 00:11:11,000 Speaker 1: over two thousand financial professionals from all over the globe. 208 00:11:11,040 --> 00:11:12,640 Speaker 1: And you're listening to the Bloomberg Radio