1 00:00:00,120 --> 00:00:02,720 Speaker 1: Hi, I'm Carol Masser and I'm Jason Kelly. It's time 2 00:00:02,720 --> 00:00:04,920 Speaker 1: for this week's cover story. Well, Carol, we're still at 3 00:00:04,920 --> 00:00:08,560 Speaker 1: the earliest months away from a working, widely available vaccine. 4 00:00:08,640 --> 00:00:12,080 Speaker 1: Until then, rapid COVID night teen tests could help close 5 00:00:12,080 --> 00:00:15,160 Speaker 1: the gap between normalcy and where we are right now. Yeah, 6 00:00:15,200 --> 00:00:18,079 Speaker 1: it's pretty simple, Jason. If Americans want to safely send 7 00:00:18,160 --> 00:00:21,000 Speaker 1: kids to school, go to a restaurant, travel somewhere, or 8 00:00:21,079 --> 00:00:24,200 Speaker 1: even host a holiday party, well, the United States needs 9 00:00:24,200 --> 00:00:28,280 Speaker 1: to test a lot more people and a lot faster. Faster, 10 00:00:28,600 --> 00:00:31,800 Speaker 1: cheaper testing which several companies are working on, may not 11 00:00:31,920 --> 00:00:34,360 Speaker 1: flag every new case of COVID, but that shouldn't mean 12 00:00:34,400 --> 00:00:37,599 Speaker 1: we should settle for the status quo that's right. At 13 00:00:37,600 --> 00:00:40,320 Speaker 1: the minimum, a new approach to testing might allow us 14 00:00:40,360 --> 00:00:44,120 Speaker 1: to enjoy a semblance of our normal lives. Coronavirus testing 15 00:00:44,159 --> 00:00:46,960 Speaker 1: could even become a habit. If not like brushing your teeth, 16 00:00:47,000 --> 00:00:50,199 Speaker 1: then at least like flossing. Check it out. If your 17 00:00:50,240 --> 00:00:53,400 Speaker 1: preferred climate as business friendly, check out Ohio with zero 18 00:00:53,400 --> 00:00:56,000 Speaker 1: presents taxes on corporate income, R and D investments, and 19 00:00:56,040 --> 00:00:58,720 Speaker 1: good sold out of state, Ohio was better for business 20 00:00:58,960 --> 00:01:02,040 Speaker 1: because Ohio was a built for followers. They're building for 21 00:01:02,200 --> 00:01:06,520 Speaker 1: leaders Ohios for leaders dot com. We can still pass 22 00:01:06,600 --> 00:01:10,400 Speaker 1: this test with the seasons changing and a vaccine a 23 00:01:10,480 --> 00:01:14,720 Speaker 1: ways off. The US needs to dramatically improve its infrastructure 24 00:01:14,720 --> 00:01:19,399 Speaker 1: for rapid COVID testing. It's got options by Drake Bennett 25 00:01:19,440 --> 00:01:24,520 Speaker 1: and Michelle fay Cortes. As undergraduates returned to the University 26 00:01:24,520 --> 00:01:27,520 Speaker 1: of Arizona for the fall semester, many of the new 27 00:01:27,560 --> 00:01:31,840 Speaker 1: precautions were hard to miss. Plexiglass dividers were affixed in 28 00:01:31,880 --> 00:01:35,720 Speaker 1: front of lecterns and between lab benches. Giant tents were 29 00:01:35,720 --> 00:01:38,640 Speaker 1: set up so students arriving early for a class could 30 00:01:38,640 --> 00:01:42,880 Speaker 1: wait outdoors, sheltered from the punishing sun. Roving teams of 31 00:01:42,920 --> 00:01:47,039 Speaker 1: student health ambassadors tooled around in golf carts, handing out 32 00:01:47,080 --> 00:01:50,160 Speaker 1: masks and politely chiding their peers for standing less than 33 00:01:50,160 --> 00:01:53,400 Speaker 1: six ft apart. But the first thing students had to 34 00:01:53,440 --> 00:01:56,240 Speaker 1: do was visit one of the university gyms for a 35 00:01:56,360 --> 00:02:00,280 Speaker 1: rapid stars cove to test. The results took an hour 36 00:02:00,960 --> 00:02:03,880 Speaker 1: negative and you could move into your residence hall right away. 37 00:02:04,320 --> 00:02:07,280 Speaker 1: Positive and you were sent to a special isolation dorm 38 00:02:07,600 --> 00:02:10,480 Speaker 1: where you spent the next ten days taking classes online. 39 00:02:11,480 --> 00:02:14,800 Speaker 1: Many of these safety measures emerged from discussions headed by 40 00:02:14,919 --> 00:02:18,000 Speaker 1: Richard Carmona, a former U S Surgeon General who is 41 00:02:18,000 --> 00:02:21,840 Speaker 1: a professor of public health at the university. Carmona's medical 42 00:02:21,880 --> 00:02:24,960 Speaker 1: career stretches back to the Vietnam War, where he served 43 00:02:25,000 --> 00:02:27,720 Speaker 1: as a Special Forces medic after dropping out of high school. 44 00:02:28,360 --> 00:02:31,880 Speaker 1: Over the years, he's developed an expertise in emergency preparedness 45 00:02:31,919 --> 00:02:36,040 Speaker 1: and disaster response. As news of the novel coronavirus began 46 00:02:36,120 --> 00:02:39,399 Speaker 1: making its way out of China last winter, the university's 47 00:02:39,440 --> 00:02:42,800 Speaker 1: president asked Carmona to form a working group and propose 48 00:02:42,840 --> 00:02:46,600 Speaker 1: ways to keep the institution functioning during a pandemic. The 49 00:02:46,680 --> 00:02:49,200 Speaker 1: question was what were the metrics were going to look 50 00:02:49,240 --> 00:02:50,799 Speaker 1: at and how are we going to be able to 51 00:02:50,840 --> 00:02:54,920 Speaker 1: make a reasonable determination that this is somewhat safe. Carmona says, 52 00:02:55,480 --> 00:02:58,640 Speaker 1: we didn't have a playbook for this. Nobody had a playbook. 53 00:03:00,000 --> 00:03:02,720 Speaker 1: In early spring, the team reached out to Ian Pepper, 54 00:03:03,160 --> 00:03:06,960 Speaker 1: an environmental microbiologist on the faculty who had experience with 55 00:03:07,040 --> 00:03:11,480 Speaker 1: wastewater testing. It used to be called sewage surveillance, says Pepper. 56 00:03:12,000 --> 00:03:16,480 Speaker 1: Now the preferred term seems to be wastewater based epidemiology. 57 00:03:16,600 --> 00:03:20,200 Speaker 1: The technique traditionally has been used in population level studies 58 00:03:20,240 --> 00:03:24,800 Speaker 1: of illegal drug use or viral infections. Carmona's team, however, 59 00:03:25,160 --> 00:03:28,160 Speaker 1: wanted to go upstream from the treatment plant to determine 60 00:03:28,200 --> 00:03:31,360 Speaker 1: not just if the coronavirus was on campus, but where 61 00:03:32,080 --> 00:03:35,920 Speaker 1: the sampling would provide an early warning system. People ill 62 00:03:35,960 --> 00:03:38,720 Speaker 1: with COVID nineteen can start shedding the virus in their 63 00:03:38,760 --> 00:03:42,560 Speaker 1: stool as many as seven days before showing symptoms. That 64 00:03:42,640 --> 00:03:46,760 Speaker 1: gives you seven precious days for intervention, Pepper says. Over 65 00:03:46,800 --> 00:03:51,240 Speaker 1: the summer, Carmona poured over university blueprints with the facilities department, 66 00:03:51,640 --> 00:03:54,920 Speaker 1: tracing decades old sewage pipes back to the dorms they drain, 67 00:03:55,440 --> 00:03:59,200 Speaker 1: while Pepper worked on filtering samples and identifying trace amounts 68 00:03:59,200 --> 00:04:02,560 Speaker 1: of the virus. By the time students returned in August, 69 00:04:02,680 --> 00:04:05,640 Speaker 1: the program was in place each morning at eight thirty, 70 00:04:05,880 --> 00:04:08,400 Speaker 1: an hour chosen to give residence a chance to visit 71 00:04:08,400 --> 00:04:12,000 Speaker 1: the bathroom. A faculty engineer working with an underground assistant 72 00:04:12,040 --> 00:04:14,800 Speaker 1: would make the rounds at each stop, prying off a 73 00:04:14,840 --> 00:04:18,520 Speaker 1: manhole cover and lowering an open nalgene water bottle at 74 00:04:18,520 --> 00:04:21,120 Speaker 1: the end of a long aluminum pole into the river 75 00:04:21,200 --> 00:04:24,400 Speaker 1: of waste below. The pair would place the samples in 76 00:04:24,440 --> 00:04:27,120 Speaker 1: a cooler and drive them back to the lab, where 77 00:04:27,120 --> 00:04:29,839 Speaker 1: Pepper's crew would turn around the results by the afternoon. 78 00:04:30,480 --> 00:04:33,440 Speaker 1: On Tuesday, August twenty fifth, a week and a half 79 00:04:33,480 --> 00:04:37,000 Speaker 1: after students started to return, Pepper got his first positive 80 00:04:37,400 --> 00:04:40,400 Speaker 1: from the pipe, leaving a dorm called Lichens Hall. The 81 00:04:40,480 --> 00:04:43,920 Speaker 1: next day, all three hundred and eleven Lichens residents took 82 00:04:43,960 --> 00:04:48,240 Speaker 1: COVID tests. Two students, both without symptoms, came back positive 83 00:04:48,279 --> 00:04:51,359 Speaker 1: and were relocated to the isolation dorm. Thanks to the 84 00:04:51,360 --> 00:04:55,960 Speaker 1: head start, no other residence would contract the virus. Since then, 85 00:04:56,120 --> 00:04:59,040 Speaker 1: the university has stemmed outbreaks in at least eight other 86 00:04:59,120 --> 00:05:03,359 Speaker 1: dorms using the same method. Pepper is scaling up his lab, 87 00:05:03,720 --> 00:05:06,560 Speaker 1: training more teams of samplers, and expanding the effort to 88 00:05:06,600 --> 00:05:10,560 Speaker 1: off campus apartments and Greek houses. He's fielding requests from 89 00:05:10,600 --> 00:05:14,320 Speaker 1: around the world for help setting up similar programs. Carmona, 90 00:05:14,400 --> 00:05:17,000 Speaker 1: for his part, is careful not to get ahead of himself. 91 00:05:17,480 --> 00:05:20,640 Speaker 1: It's a tool that's just evolving, he says, But we 92 00:05:20,720 --> 00:05:25,240 Speaker 1: see value. Ever since the novel coronavirus began circulating in 93 00:05:25,279 --> 00:05:28,279 Speaker 1: the US, the country's response has been crippled by a 94 00:05:28,320 --> 00:05:31,400 Speaker 1: failure to see the spread in anything close to real time. 95 00:05:32,080 --> 00:05:35,120 Speaker 1: Half a year after the first wave of US lockdowns, 96 00:05:35,160 --> 00:05:38,080 Speaker 1: with more than two hundred thousand Americans dead from COVID, 97 00:05:38,480 --> 00:05:42,520 Speaker 1: we're still playing catch up. The Trump Administration's botched rollout 98 00:05:42,520 --> 00:05:45,479 Speaker 1: of its first tests and the supply chain shortages that 99 00:05:45,560 --> 00:05:50,880 Speaker 1: followed helped the disease spread unchecked. Today, processing bottlenecks still 100 00:05:50,920 --> 00:05:54,520 Speaker 1: render many test results worthless by the time people get them. 101 00:05:54,560 --> 00:05:57,719 Speaker 1: This blindness has left public health officials only the crudest 102 00:05:57,720 --> 00:06:01,520 Speaker 1: measures of containment, such as braw add social distancing mandates 103 00:06:01,640 --> 00:06:06,120 Speaker 1: and lockdowns. It's turned the loosening of restrictions on restaurants, 104 00:06:06,200 --> 00:06:10,480 Speaker 1: sports offices, gems, and schools into terrifying leaps of faith, 105 00:06:11,040 --> 00:06:14,360 Speaker 1: and it has surely killed people. The testing we are 106 00:06:14,400 --> 00:06:17,719 Speaker 1: doing today is mostly just keeping score for the virus. 107 00:06:17,880 --> 00:06:22,480 Speaker 1: Since William Hannage, an epidemiology professor at Harvard, even that 108 00:06:22,560 --> 00:06:25,360 Speaker 1: grim framing gives the u S system too much credit. 109 00:06:25,839 --> 00:06:29,279 Speaker 1: The Centers for Disease Control and Preventions sampling of Americans 110 00:06:29,279 --> 00:06:32,640 Speaker 1: with stars COVE two antibodies shows that the true number 111 00:06:32,680 --> 00:06:35,320 Speaker 1: of infections is as many as seven times higher than 112 00:06:35,360 --> 00:06:39,520 Speaker 1: the official count. Over time, though, the problem of testing 113 00:06:39,560 --> 00:06:44,080 Speaker 1: has attracted new focus, new thinking, and new money. Experimental 114 00:06:44,160 --> 00:06:48,440 Speaker 1: viral screening technologies have taken big steps forward, and researchers 115 00:06:48,480 --> 00:06:52,040 Speaker 1: have found ways to retool existing procedures. Some of that 116 00:06:52,080 --> 00:06:54,440 Speaker 1: work isn't likely to pay off in time to change 117 00:06:54,440 --> 00:06:57,800 Speaker 1: the course of the pandemic, but some of it already has, 118 00:06:58,000 --> 00:07:02,200 Speaker 1: and the outbreak's global scale has rd epidemiologists and policymakers 119 00:07:02,480 --> 00:07:05,720 Speaker 1: to seek better answers to fundamental questions about the management 120 00:07:05,760 --> 00:07:09,080 Speaker 1: of a modern plague, not only how to test, but 121 00:07:09,200 --> 00:07:14,240 Speaker 1: whom to test and why. Those debates are particularly vital now. 122 00:07:14,880 --> 00:07:17,920 Speaker 1: The number of new US COVID cases, which peaked this 123 00:07:17,960 --> 00:07:22,280 Speaker 1: summer before dropping significantly, is climbing again. The c d 124 00:07:22,320 --> 00:07:25,400 Speaker 1: c's seven day moving average rose from thirty four thousand, 125 00:07:25,480 --> 00:07:29,400 Speaker 1: three D seventy one on September twelve to forty four thousand, 126 00:07:29,400 --> 00:07:34,680 Speaker 1: three D seven on September Colder weather and classroom reopenings 127 00:07:34,800 --> 00:07:37,240 Speaker 1: threatened an explosion of cases at a time when the 128 00:07:37,240 --> 00:07:41,280 Speaker 1: public has tired of social distancing's heavy costs, and we're 129 00:07:41,360 --> 00:07:44,920 Speaker 1: still at the earliest months away from a working, widely 130 00:07:44,960 --> 00:07:49,600 Speaker 1: available vaccine. Until then testing can help close the gap 131 00:07:49,680 --> 00:07:53,280 Speaker 1: between normalcy and where we are. If Americans want to 132 00:07:53,320 --> 00:07:56,720 Speaker 1: safely send kids to school, eat in a cafe, go 133 00:07:56,800 --> 00:07:59,560 Speaker 1: to a basketball game, or get on a plane, the 134 00:07:59,680 --> 00:08:04,400 Speaker 1: US needs to test a lot more people, a lot faster, faster, cheaper. 135 00:08:04,440 --> 00:08:07,480 Speaker 1: Testing may not flag every new case of COVID, but 136 00:08:07,560 --> 00:08:10,720 Speaker 1: that shouldn't mean settling for the current level of blindness 137 00:08:10,760 --> 00:08:14,880 Speaker 1: with its tortuous drip of preventable deaths. Even world class 138 00:08:14,880 --> 00:08:17,480 Speaker 1: testing won't rid us of the virus, but it can 139 00:08:17,560 --> 00:08:22,600 Speaker 1: allow us to live our lives in the meanwhile. Well 140 00:08:22,640 --> 00:08:25,520 Speaker 1: before this year, the US had ample warning about the 141 00:08:25,520 --> 00:08:29,520 Speaker 1: health care system's vulnerability to a pandemic. An industry long 142 00:08:29,640 --> 00:08:32,960 Speaker 1: kept as lean as possible, lacked the personnel and hospital 143 00:08:33,000 --> 00:08:36,480 Speaker 1: beds needed to respond to a national crisis, let alone 144 00:08:36,520 --> 00:08:40,880 Speaker 1: the protective gear and ventilators. The coronavirus requires. Testing was 145 00:08:40,920 --> 00:08:44,200 Speaker 1: the one thing the US had supposedly handled. The c 146 00:08:44,360 --> 00:08:48,080 Speaker 1: DCS early warning system for epidemics, based on reports from 147 00:08:48,080 --> 00:08:51,520 Speaker 1: medical professionals all over the country, was designed to spot 148 00:08:51,600 --> 00:08:54,760 Speaker 1: new diseases in time to head off bigger problems, and 149 00:08:54,800 --> 00:08:58,120 Speaker 1: the technology to create tests for new viral diseases is 150 00:08:58,160 --> 00:09:01,520 Speaker 1: so straightforward. It can really be done in a few days. 151 00:09:02,360 --> 00:09:05,800 Speaker 1: When the time came, though, the apparatus worked against itself. 152 00:09:06,440 --> 00:09:10,480 Speaker 1: After its Chinese counterparts published stars Cove two's genetic sequence 153 00:09:10,520 --> 00:09:14,360 Speaker 1: on January eleven, the CDC did indeed create its own 154 00:09:14,360 --> 00:09:17,679 Speaker 1: test in a matter of days, but because of regulatory 155 00:09:17,720 --> 00:09:21,680 Speaker 1: requirements and limited access to the relevant viral samples, the 156 00:09:21,760 --> 00:09:25,000 Speaker 1: agency's Atlanta headquarters was the only place it could be done. 157 00:09:25,559 --> 00:09:29,199 Speaker 1: In early February, the CDC produced tests that state labs 158 00:09:29,240 --> 00:09:32,160 Speaker 1: around the country could use, but they were faulty and 159 00:09:32,240 --> 00:09:36,800 Speaker 1: returned in conclusive results. Public and private clinical labs rushed 160 00:09:36,840 --> 00:09:39,160 Speaker 1: to fill the void, only to be stymied by the 161 00:09:39,160 --> 00:09:42,640 Speaker 1: Food and Drug Administration, which demanded extensive data and a 162 00:09:42,720 --> 00:09:48,280 Speaker 1: regulatory submission before authorizing alternatives. By early March, the US 163 00:09:48,360 --> 00:09:51,280 Speaker 1: was struggling to run one thousand tests a day, while 164 00:09:51,320 --> 00:09:54,199 Speaker 1: South Korea, which confirmed its first case the same day 165 00:09:54,240 --> 00:09:57,840 Speaker 1: the US did, was running ten thousand. By the end 166 00:09:57,840 --> 00:10:02,040 Speaker 1: of that month, lab giants, ab Labs, hal Logic Lab, Corps, 167 00:10:02,120 --> 00:10:05,360 Speaker 1: Quest Diagnostics, and Roche had rolled out US tests of 168 00:10:05,360 --> 00:10:08,160 Speaker 1: their own, but at one to a hundred and fifty 169 00:10:08,160 --> 00:10:11,600 Speaker 1: dollars apiece, they were expensive and labs were short on 170 00:10:11,679 --> 00:10:15,719 Speaker 1: technicians trained to run them. Long complex supply chains led 171 00:10:15,760 --> 00:10:19,520 Speaker 1: to further shortages from the swabs needed to gather nasopharyngeal 172 00:10:19,600 --> 00:10:23,480 Speaker 1: samples to the reagents used to process the tests. The 173 00:10:23,559 --> 00:10:26,800 Speaker 1: tests in use at the time were molecular diagnostics known 174 00:10:26,840 --> 00:10:31,520 Speaker 1: as polymerase chain reaction tests, performed by medical professionals and 175 00:10:31,600 --> 00:10:35,959 Speaker 1: processed in specialized labs. PCR tests identify segments of a 176 00:10:36,040 --> 00:10:39,720 Speaker 1: virus's genetic material in secretions swabbed from the back of 177 00:10:39,760 --> 00:10:43,800 Speaker 1: a patient's throat or nose. The process starts with enzymes 178 00:10:43,840 --> 00:10:46,840 Speaker 1: being added to the sample, which is then repeatedly heated 179 00:10:46,880 --> 00:10:50,040 Speaker 1: and cooled to create billions of copies of the viral genome. 180 00:10:50,600 --> 00:10:54,960 Speaker 1: Special probe molecules bind to the copy genetic material, releasing 181 00:10:54,960 --> 00:11:00,480 Speaker 1: fluorescing nanoparticles whose globe signals the virus's presence. Used everything 182 00:11:00,520 --> 00:11:04,840 Speaker 1: from food safety to DNA profiling. PCR tests take several 183 00:11:04,840 --> 00:11:08,480 Speaker 1: hours and are extremely sensitive. If the virus is present 184 00:11:08,520 --> 00:11:12,680 Speaker 1: in a sample, even in infinitesimal amounts, PCR will find 185 00:11:12,720 --> 00:11:15,560 Speaker 1: it to public health officials. In the early days of 186 00:11:15,559 --> 00:11:19,840 Speaker 1: the pandemic, reliability seemed like the most important quality, but 187 00:11:19,960 --> 00:11:23,520 Speaker 1: the hospitals, dodgers offices, and pop up testing facilities where 188 00:11:23,559 --> 00:11:26,640 Speaker 1: PCR tests are given often don't have the equipment to 189 00:11:26,679 --> 00:11:30,480 Speaker 1: process the results on site. The thermo cycler that incubates 190 00:11:30,520 --> 00:11:33,600 Speaker 1: the samples costs at least a hundred thousand dollars, so 191 00:11:33,640 --> 00:11:37,200 Speaker 1: the swabs are usually sent out. That's resulted in massive 192 00:11:37,240 --> 00:11:43,160 Speaker 1: backlogs and severely limited the tests usefulness. There are alternatives. One. 193 00:11:43,360 --> 00:11:46,760 Speaker 1: A lateral flow test is a disposable strip of cellulose 194 00:11:46,840 --> 00:11:50,800 Speaker 1: or woven fiber picture a home pregnancy test. Instead of 195 00:11:50,840 --> 00:11:54,960 Speaker 1: looking for viral DNA or RNA, it identifies proteins called 196 00:11:55,000 --> 00:11:59,040 Speaker 1: antigens that protrude from the virus capsule. It exploits the 197 00:11:59,120 --> 00:12:02,880 Speaker 1: lock and key relationship between those molecules and the antibodies 198 00:12:02,920 --> 00:12:06,920 Speaker 1: the human immune system makes to identify them. Lateral flow 199 00:12:07,000 --> 00:12:09,920 Speaker 1: tests can be done on nasal swabs, but some are 200 00:12:09,920 --> 00:12:13,520 Speaker 1: in development to work with saliva. The sample is deposited 201 00:12:13,559 --> 00:12:16,760 Speaker 1: at one end, doused with liquid, and then spreads through 202 00:12:16,760 --> 00:12:20,560 Speaker 1: the fiber by capillary action, like a spill infusing a sponge. 203 00:12:21,240 --> 00:12:24,599 Speaker 1: As it advances, the solution flows over antibodies embedded in 204 00:12:24,640 --> 00:12:28,160 Speaker 1: the fiber with nanoparticles of gold or dye grafted onto 205 00:12:28,240 --> 00:12:31,520 Speaker 1: them as tags. If the virus is present in the sample, 206 00:12:31,880 --> 00:12:34,360 Speaker 1: the antibodies latch on and are carried along until the 207 00:12:34,440 --> 00:12:38,079 Speaker 1: virus antibody pair encounters a second set of antibodies anchored 208 00:12:38,120 --> 00:12:42,199 Speaker 1: in a line. Those two grab onto the target viruses, 209 00:12:42,480 --> 00:12:45,680 Speaker 1: activating the tags on the antibodies that hitch deride earlier. 210 00:12:46,120 --> 00:12:49,560 Speaker 1: As more virus rich liquid reaches the line, the tags, 211 00:12:49,679 --> 00:12:53,599 Speaker 1: like millions of microscopic pixels, form the telltale stripe of 212 00:12:53,640 --> 00:12:56,760 Speaker 1: a positive result. The whole process can take as little 213 00:12:56,760 --> 00:13:01,240 Speaker 1: as fifteen minutes or Assure Technologies has long sold lateral 214 00:13:01,280 --> 00:13:05,520 Speaker 1: flow tests for habititis C and HIV. In twenties seventeen, 215 00:13:05,600 --> 00:13:09,640 Speaker 1: it created the only FDA approved ebola antigen test. The 216 00:13:09,720 --> 00:13:13,400 Speaker 1: company is based in Bethlehem, Pennsylvania, but sells many of 217 00:13:13,440 --> 00:13:16,840 Speaker 1: its fast, cheap, over the counter diagnostics in sub Saharan 218 00:13:16,880 --> 00:13:21,160 Speaker 1: African nations that lack the medical infrastructure for PCR testing. 219 00:13:21,800 --> 00:13:24,120 Speaker 1: At the beginning of this year, with the U S 220 00:13:24,120 --> 00:13:28,559 Speaker 1: struggling to create reliable tests and its most advanced labs overwhelmed, 221 00:13:29,000 --> 00:13:33,040 Speaker 1: chief executive Officer Stephen Tang saw the parallels we have 222 00:13:33,120 --> 00:13:36,600 Speaker 1: to repatriate our experience from low and middle income countries. 223 00:13:36,720 --> 00:13:39,680 Speaker 1: He says, you have a test that is rapid, that 224 00:13:39,760 --> 00:13:42,760 Speaker 1: you can take by yourself, that doesn't require an instrument 225 00:13:42,760 --> 00:13:46,040 Speaker 1: to read or a medical professional to administer. What we 226 00:13:46,080 --> 00:13:49,320 Speaker 1: have learned from experience is that people will test themselves 227 00:13:49,360 --> 00:13:52,800 Speaker 1: more frequently in the privacy of their own homes. Tang 228 00:13:52,880 --> 00:13:56,320 Speaker 1: plans to build on the company's HIV test platform to 229 00:13:56,400 --> 00:13:58,679 Speaker 1: bring an at home COVID test to market before the 230 00:13:58,760 --> 00:14:01,920 Speaker 1: end of the year. While the HIV test costs forty 231 00:14:02,000 --> 00:14:04,840 Speaker 1: to fifty dollars in a U S pharmacy, the company 232 00:14:04,880 --> 00:14:09,439 Speaker 1: promises its coronavirus test will be cheaper. Other strip test 233 00:14:09,520 --> 00:14:14,680 Speaker 1: makers have also prioritized the pandemic. Eive Bio, a startup 234 00:14:14,679 --> 00:14:17,280 Speaker 1: born in an m I T lab two years ago, 235 00:14:17,520 --> 00:14:21,120 Speaker 1: has temporarily shifted its focus from epidemic fever viruses such 236 00:14:21,160 --> 00:14:25,040 Speaker 1: as dingey and zica with COVID. There have been maybe 237 00:14:25,040 --> 00:14:30,640 Speaker 1: fifty million infections worldwide, says CEO Bobby Brooke Herrera. Dinge 238 00:14:30,680 --> 00:14:35,320 Speaker 1: causes four hundred million every single year. Like Tang, Herrera 239 00:14:35,400 --> 00:14:38,280 Speaker 1: has been trying to apply lessons from countries with threadbare 240 00:14:38,360 --> 00:14:41,880 Speaker 1: public health systems to those like the US he's in 241 00:14:41,920 --> 00:14:46,000 Speaker 1: discussions with US regulators to authorize a coronavirus strip test 242 00:14:46,360 --> 00:14:49,280 Speaker 1: made to be processed in a lab. Once it reaches 243 00:14:49,320 --> 00:14:53,200 Speaker 1: the market, he says a home version will be next established. 244 00:14:53,240 --> 00:14:56,880 Speaker 1: Testing companies are already bringing lateral flow tests to market. 245 00:14:57,520 --> 00:15:01,040 Speaker 1: On August, Abbott Laboratory Is announced that the f d 246 00:15:01,200 --> 00:15:04,560 Speaker 1: A had awarded it an emergency use authorization for bin as, 247 00:15:04,680 --> 00:15:09,600 Speaker 1: now a fifteen minute disposable antigen test priced at five dollars, 248 00:15:09,800 --> 00:15:12,560 Speaker 1: A so called point of care test, it must be 249 00:15:12,600 --> 00:15:15,560 Speaker 1: given by a health professional, but since it requires no 250 00:15:15,680 --> 00:15:19,240 Speaker 1: lab equipment, an unlimited number can be conducted and processed 251 00:15:19,280 --> 00:15:23,160 Speaker 1: at any given time. Abbott is already producing fifty million 252 00:15:23,200 --> 00:15:29,000 Speaker 1: of them a month. A test's accuracy is a matter 253 00:15:29,040 --> 00:15:33,920 Speaker 1: of sensitivity, how often it correctly spots a disease, and specificity, 254 00:15:34,280 --> 00:15:37,600 Speaker 1: how often it correctly rules the disease out. A test 255 00:15:37,640 --> 00:15:40,640 Speaker 1: with low sensitivity will miss a lot of cases. A 256 00:15:40,720 --> 00:15:43,680 Speaker 1: test with low specificity will mistakenly tell people they have 257 00:15:43,720 --> 00:15:47,000 Speaker 1: a disease when they don't. Lateral flow tests are neither 258 00:15:47,080 --> 00:15:51,360 Speaker 1: as sensitive nor as specific as PCR tests. They're more 259 00:15:51,400 --> 00:15:54,600 Speaker 1: likely to miss an infection during the incubation period as 260 00:15:54,640 --> 00:15:58,120 Speaker 1: the invader has just started replicating, or weeks in when 261 00:15:58,160 --> 00:16:01,160 Speaker 1: the body's immune response has managed to eliminate many of 262 00:16:01,200 --> 00:16:05,960 Speaker 1: the virus particles. Lateral flow tests lower sensitivity has hampered 263 00:16:05,960 --> 00:16:09,040 Speaker 1: efforts to bring them to market. There are concerns that 264 00:16:09,160 --> 00:16:12,560 Speaker 1: tests done at home, where people swab their own noses 265 00:16:12,600 --> 00:16:15,880 Speaker 1: instead of having a professional du it or at least supervise, 266 00:16:16,280 --> 00:16:20,200 Speaker 1: could further lessen the sensitivity. Herrera says he doubts E 267 00:16:20,320 --> 00:16:23,440 Speaker 1: twenty five bios at home test will be approved without 268 00:16:23,440 --> 00:16:27,560 Speaker 1: a change in expectations from the FDA, which requires accuracy 269 00:16:27,640 --> 00:16:31,160 Speaker 1: levels difficult for him to achieve outside a lab or. 270 00:16:31,200 --> 00:16:35,080 Speaker 1: Asher says it's confident it concluded the bar. Some companies 271 00:16:35,120 --> 00:16:40,360 Speaker 1: are trying to address this shortcoming technologically. Mammoth Biosciences, working 272 00:16:40,400 --> 00:16:43,360 Speaker 1: with a microbiologist named Charles Chew at the University of 273 00:16:43,400 --> 00:16:47,520 Speaker 1: California at San Francisco, is using the DNA splicing technology 274 00:16:47,560 --> 00:16:51,760 Speaker 1: Crisper to improve the accuracy of strip tests. Crisper's potential 275 00:16:51,840 --> 00:16:55,280 Speaker 1: for precise gene editing rests on its use of sequences 276 00:16:55,280 --> 00:16:59,520 Speaker 1: of guide RNA that zero in on target genes. Chew 277 00:16:59,680 --> 00:17:02,360 Speaker 1: and a meth are turning that search engine property to 278 00:17:02,400 --> 00:17:05,840 Speaker 1: the task of finding the telltale genome of SARS cove two. 279 00:17:06,880 --> 00:17:10,520 Speaker 1: The effort is taking two parallel paths. One that the 280 00:17:10,560 --> 00:17:13,520 Speaker 1: FDA cleared this summer runs on the same equipment as 281 00:17:13,600 --> 00:17:17,320 Speaker 1: PCR tests, but it copies the viral genetic material without 282 00:17:17,320 --> 00:17:20,960 Speaker 1: the time consuming heating cycles. The other, in development with 283 00:17:21,000 --> 00:17:24,920 Speaker 1: Glaxo Smith Klein manages to replicate this approach with the 284 00:17:24,960 --> 00:17:28,760 Speaker 1: attendant sensitivity in a self contained and disposable kit. Not 285 00:17:28,960 --> 00:17:32,840 Speaker 1: unlike a lateral flow test. You're getting the same accuracy 286 00:17:32,960 --> 00:17:35,200 Speaker 1: as in the lab, but it's much easier to use, 287 00:17:35,440 --> 00:17:39,959 Speaker 1: says CEO Trevor Martin. Another school of thought, though, holds 288 00:17:40,000 --> 00:17:43,280 Speaker 1: that worries about the sensitivity of strip tests missed the point. 289 00:17:43,800 --> 00:17:46,120 Speaker 1: The way we've been approaching testing so far in this 290 00:17:46,160 --> 00:17:48,920 Speaker 1: epidemic is to try to shove a public health need 291 00:17:48,960 --> 00:17:53,480 Speaker 1: through a diagnostic pathway, says Michael Mina, the Harvard epidemiologist 292 00:17:53,520 --> 00:17:56,879 Speaker 1: who is the leading proponent of this idea. Mina argues 293 00:17:56,920 --> 00:18:00,560 Speaker 1: that we should essentially test everyone, all the time, everywhere. 294 00:18:01,200 --> 00:18:04,120 Speaker 1: It's a form of what public health experts call surveillance 295 00:18:04,600 --> 00:18:08,879 Speaker 1: rather than diagnostic testing. In this model, speed and ubiquity 296 00:18:08,920 --> 00:18:12,399 Speaker 1: are all that matter, Mina likes to talk about what 297 00:18:12,440 --> 00:18:16,000 Speaker 1: would happen if we had one dollar self administered saliva tests. 298 00:18:16,440 --> 00:18:19,199 Speaker 1: Restaurants and bars would have cups of strips on the 299 00:18:19,240 --> 00:18:22,520 Speaker 1: major dast end by the toothpicks and the mints. Theaters 300 00:18:22,560 --> 00:18:25,320 Speaker 1: would have them at the door. Air travelers would be 301 00:18:25,320 --> 00:18:28,880 Speaker 1: tested at their departure gate before boarding. The International Air 302 00:18:28,920 --> 00:18:32,520 Speaker 1: Transport Association recently announced its determination to put a system 303 00:18:32,600 --> 00:18:36,040 Speaker 1: like this in place. Coronavirus testing would become a habit. 304 00:18:36,520 --> 00:18:39,600 Speaker 1: If not like brushing our teeth, then at least like flossing. 305 00:18:40,280 --> 00:18:43,720 Speaker 1: These tests would be much more reliable than temperature checks, 306 00:18:43,720 --> 00:18:47,119 Speaker 1: which can miss carriers with mild or non existent symptoms. 307 00:18:47,920 --> 00:18:50,399 Speaker 1: At a large enough scale and a high enough frequency, 308 00:18:50,720 --> 00:18:53,520 Speaker 1: the thinking goes, testing is all you need to do. 309 00:18:54,160 --> 00:18:57,200 Speaker 1: Tests at the entrance to offices and schools would visibly 310 00:18:57,320 --> 00:19:00,879 Speaker 1: ensure the safety of those spaces encourage people to return 311 00:19:00,920 --> 00:19:05,440 Speaker 1: to them. People who test positive could immediately isolate themselves, 312 00:19:05,480 --> 00:19:09,040 Speaker 1: breaking the chain of transmission. In this world, a strip 313 00:19:09,080 --> 00:19:12,840 Speaker 1: test's relative insensitivity would be less of an issue. Positives 314 00:19:12,840 --> 00:19:15,359 Speaker 1: could be double checked to make sure they're correct, and 315 00:19:15,400 --> 00:19:17,600 Speaker 1: false negatives would be caught. A day or two later 316 00:19:17,680 --> 00:19:20,800 Speaker 1: by the next test, still early in the disease course. 317 00:19:21,560 --> 00:19:24,679 Speaker 1: Mina goes so far is to characterize lower sensitivity as 318 00:19:24,680 --> 00:19:27,800 Speaker 1: an asset because a PCR test taken in the late 319 00:19:27,840 --> 00:19:31,520 Speaker 1: stages of COVID nineteen will still show positive even if 320 00:19:31,560 --> 00:19:34,240 Speaker 1: the patient is well past the contagious stage and no 321 00:19:34,320 --> 00:19:38,560 Speaker 1: longer needs to be isolated. In that sense, he argues, 322 00:19:38,720 --> 00:19:41,760 Speaker 1: strip tests can better gauge in individual's risks to the 323 00:19:41,760 --> 00:19:44,520 Speaker 1: broader population. I don't want to see these kinds of 324 00:19:44,560 --> 00:19:47,560 Speaker 1: tests being promoted as passports to party or to go 325 00:19:47,600 --> 00:19:51,320 Speaker 1: out to dinner. That misses the big picture. The epidemiologist says, 326 00:19:51,920 --> 00:19:55,639 Speaker 1: these aren't passports. These are actually the intervention lack of 327 00:19:55,720 --> 00:20:01,240 Speaker 1: vaccine to suppress population spread. According to his Budeling, testing 328 00:20:01,359 --> 00:20:04,480 Speaker 1: just half the population every three days would bring COVID 329 00:20:04,560 --> 00:20:08,320 Speaker 1: under control within weeks. To make this a reality, the 330 00:20:08,400 --> 00:20:11,720 Speaker 1: FDA would need to relax its testing standards down from 331 00:20:11,840 --> 00:20:15,679 Speaker 1: PCR level sensitivity, and someone would need to manufacture and 332 00:20:15,720 --> 00:20:19,240 Speaker 1: pay for the untold billions of tests. Mina believes it 333 00:20:19,280 --> 00:20:22,800 Speaker 1: should be Congress. This is a national emergency, he says, 334 00:20:23,359 --> 00:20:26,200 Speaker 1: and a fifty billion dollar or one billion dollar price 335 00:20:26,240 --> 00:20:29,359 Speaker 1: tag to stop the virus is easily worth it, given 336 00:20:29,400 --> 00:20:32,000 Speaker 1: that the US has already spent three trillion dollars in 337 00:20:32,080 --> 00:20:36,000 Speaker 1: COVID related stimulus money and its economy has lost trillions more. 338 00:20:37,119 --> 00:20:39,680 Speaker 1: At least one of the two men running for president 339 00:20:39,840 --> 00:20:43,440 Speaker 1: has unequivocally committed to more testing. The first point in 340 00:20:43,520 --> 00:20:47,120 Speaker 1: Joe Biden's seven point COVID plan is to ensure all 341 00:20:47,160 --> 00:20:51,280 Speaker 1: Americans have access to regular, reliable, and free testing. The 342 00:20:51,320 --> 00:20:54,679 Speaker 1: plan mentions at home and instant tests and proposes a 343 00:20:54,720 --> 00:20:58,200 Speaker 1: testing board modeled on Franklin D. Roosevelt's War Production Board, 344 00:20:58,720 --> 00:21:01,960 Speaker 1: which oversaw the Manu facture of weapons and supplies that 345 00:21:02,040 --> 00:21:06,280 Speaker 1: helped win World War Two. President Trump has publicly called 346 00:21:06,320 --> 00:21:10,359 Speaker 1: for less testing, and his CDC recently said asymptomatic people 347 00:21:10,359 --> 00:21:13,119 Speaker 1: who've had contact with a sick person don't need to 348 00:21:13,160 --> 00:21:17,520 Speaker 1: be tested. Most public health experts strongly disagree, and the 349 00:21:17,560 --> 00:21:20,960 Speaker 1: agency has since reversed that guidance. On the other hand, 350 00:21:21,200 --> 00:21:24,840 Speaker 1: the day after ABBOT unveiled its lateral flow kits, the 351 00:21:24,960 --> 00:21:27,960 Speaker 1: U S Department of Health and Human Services announced a 352 00:21:28,000 --> 00:21:31,400 Speaker 1: deal to buy and deploy one fifty million of them, 353 00:21:31,440 --> 00:21:34,040 Speaker 1: and the agency is already distributing a different type of 354 00:21:34,080 --> 00:21:37,720 Speaker 1: antigen tests to nursing homes across the country. Of course, 355 00:21:37,880 --> 00:21:40,080 Speaker 1: all of this is a fraction of what Mina's plan 356 00:21:40,160 --> 00:21:44,840 Speaker 1: would require. Among his fellow epidemiologists and public health experts, 357 00:21:45,080 --> 00:21:49,280 Speaker 1: Mina's plan does have skeptics. Without reimbursement, the price of 358 00:21:49,280 --> 00:21:51,760 Speaker 1: even very cheap tests might be a challenge for some 359 00:21:51,880 --> 00:21:55,760 Speaker 1: families and organizations. New York City School system has more 360 00:21:55,800 --> 00:21:59,440 Speaker 1: than one million students. The production of billions of new 361 00:21:59,480 --> 00:22:03,080 Speaker 1: tests could create supply chain problems of its own, and 362 00:22:03,160 --> 00:22:06,119 Speaker 1: the millions of false positives and negatives that would be 363 00:22:06,119 --> 00:22:10,480 Speaker 1: produced at that scale could further undermine American's shaky confidence 364 00:22:10,480 --> 00:22:13,600 Speaker 1: in their public health system, a dangerous prospect in a 365 00:22:13,640 --> 00:22:18,080 Speaker 1: country where large numbers already refused to wear masks. There's 366 00:22:18,119 --> 00:22:21,440 Speaker 1: also no mechanism to compel people who test positive at 367 00:22:21,440 --> 00:22:24,680 Speaker 1: home to stay there, especially if they're living paycheck to 368 00:22:24,720 --> 00:22:28,359 Speaker 1: paycheck without paid sick leave. It's our failure to act 369 00:22:28,400 --> 00:22:30,920 Speaker 1: on the test results we have that has been the problem, 370 00:22:31,200 --> 00:22:35,200 Speaker 1: these skeptics, argue. As Henage, Mina's colleague at Harvard, points 371 00:22:35,200 --> 00:22:39,240 Speaker 1: out South Korea succeeded in corralling the virus by relentlessly 372 00:22:39,280 --> 00:22:42,200 Speaker 1: tracking down those put at risk by each discovered case, 373 00:22:42,800 --> 00:22:46,960 Speaker 1: not by reinventing testing. All of these extraordinarily smart people 374 00:22:47,000 --> 00:22:50,959 Speaker 1: are coming up with extraordinarily smart things, Hennage says, and 375 00:22:51,000 --> 00:22:56,000 Speaker 1: we haven't done the basic things right. Whether or not 376 00:22:56,200 --> 00:22:59,119 Speaker 1: MINA can sell the idea of regular tests for all 377 00:22:59,440 --> 00:23:03,600 Speaker 1: the imports of faster, more widespread surveillance testing has become clear. 378 00:23:04,240 --> 00:23:06,800 Speaker 1: Such a model could use strip tests if they can 379 00:23:06,840 --> 00:23:09,480 Speaker 1: be scaled up, or it could rely on methods such 380 00:23:09,520 --> 00:23:13,720 Speaker 1: as pooling combining multiple samples to increase the throughput of labs. 381 00:23:14,320 --> 00:23:18,399 Speaker 1: Hann Edge is particularly excited about the potential of wastewater. A. 382 00:23:18,520 --> 00:23:21,320 Speaker 1: Shish Jaw, a physician and the dean of the Brown 383 00:23:21,400 --> 00:23:24,600 Speaker 1: University School of Public Health, is among the scholars who 384 00:23:24,640 --> 00:23:27,440 Speaker 1: have tried to calculate how many tests the country actually 385 00:23:27,480 --> 00:23:30,800 Speaker 1: needs early in the pandemic. His team came up with 386 00:23:30,840 --> 00:23:33,359 Speaker 1: a range of five hundred thousand to six hundred thousand 387 00:23:33,400 --> 00:23:37,520 Speaker 1: per day. Those estimates, though assumed that positive results would 388 00:23:37,560 --> 00:23:41,880 Speaker 1: be followed by South Korea style contact tracing. So far, 389 00:23:42,119 --> 00:23:45,400 Speaker 1: such programs have largely failed in the US, and Jaw 390 00:23:45,560 --> 00:23:49,520 Speaker 1: is reassessing. I have increasingly come to believe that a 391 00:23:49,600 --> 00:23:52,880 Speaker 1: large army of contact tracers may not work in our country, 392 00:23:52,960 --> 00:23:56,199 Speaker 1: he says, and that will need large scale surveillance testing 393 00:23:56,240 --> 00:23:58,640 Speaker 1: as a strategy for building a high degree of safety 394 00:23:58,720 --> 00:24:02,280 Speaker 1: into a lot of our activity these Jaw's new approach 395 00:24:02,440 --> 00:24:05,760 Speaker 1: focuses less on how many tests the nation needs than 396 00:24:05,840 --> 00:24:09,200 Speaker 1: on where they're needed. Nursing homes and hospitals are places 397 00:24:09,200 --> 00:24:11,800 Speaker 1: where people should be tested all the time, he argues. 398 00:24:12,160 --> 00:24:16,240 Speaker 1: With meat packing plants, prisons and schools close behind, you 399 00:24:16,240 --> 00:24:18,280 Speaker 1: could make the case for any place where you can 400 00:24:18,280 --> 00:24:22,080 Speaker 1: get large numbers of people gathering indoors for extended periods. 401 00:24:22,119 --> 00:24:25,119 Speaker 1: He says. My argument has been that we have to 402 00:24:25,160 --> 00:24:28,040 Speaker 1: make decisions if we don't have tens of millions of 403 00:24:28,040 --> 00:24:30,720 Speaker 1: tests a day, and we don't who do we want 404 00:24:30,760 --> 00:24:35,160 Speaker 1: to leave out. The American healthcare system, with its balkanized 405 00:24:35,200 --> 00:24:40,520 Speaker 1: tangle of private and public providers, consumers, and often reluctant reimbursers, 406 00:24:40,760 --> 00:24:45,399 Speaker 1: is structurally resistant to nationwide interventions. With a few exceptions, 407 00:24:45,640 --> 00:24:48,119 Speaker 1: we don't have a national or even a statewide public 408 00:24:48,160 --> 00:24:52,760 Speaker 1: health infrastructure that scales to administering many many procedures directly 409 00:24:52,800 --> 00:24:57,040 Speaker 1: to patients, says Katerine Hempstead, a healthcare policy adviser at 410 00:24:57,080 --> 00:25:01,280 Speaker 1: the Robert Wood Johnson Foundation. It's possible that an imagined 411 00:25:01,320 --> 00:25:05,359 Speaker 1: pandemic testing board on a war footing could overcome some 412 00:25:05,480 --> 00:25:09,200 Speaker 1: of those limitations. If not, and at least until then, 413 00:25:09,680 --> 00:25:12,359 Speaker 1: it's likely that the US will see the uneven growth 414 00:25:12,400 --> 00:25:17,440 Speaker 1: of the patchwork testing quilt. We already have individual companies, schools, 415 00:25:17,560 --> 00:25:21,040 Speaker 1: even states could put together effective testing programs while other 416 00:25:21,080 --> 00:25:24,480 Speaker 1: efforts fail. In August, a group of governors announced to 417 00:25:24,520 --> 00:25:28,040 Speaker 1: joint effort with the Rockefeller Foundation to purchase millions of 418 00:25:28,040 --> 00:25:33,399 Speaker 1: antigen tests. The patchwork model means gaps, blind spots, and inequity, 419 00:25:33,840 --> 00:25:37,000 Speaker 1: but it will nonetheless embed the idea of disease surveillance 420 00:25:37,000 --> 00:25:40,600 Speaker 1: in our lives long after this pandemic is over. One 421 00:25:40,640 --> 00:25:43,240 Speaker 1: of the problems that's bedeviled the u S response at 422 00:25:43,280 --> 00:25:47,240 Speaker 1: every level is the nation's short attention span. Public and 423 00:25:47,359 --> 00:25:50,840 Speaker 1: private funding goes to swine flu or zeca or ribola, 424 00:25:51,000 --> 00:25:55,480 Speaker 1: then evaporates once the immediate danger has passed. It's short sighted. 425 00:25:55,760 --> 00:25:57,720 Speaker 1: The fact that we only deal with the outbreak of 426 00:25:57,720 --> 00:26:00,960 Speaker 1: the day says you see s F. S. Chew. Had 427 00:26:01,000 --> 00:26:04,680 Speaker 1: we had ongoing funding to do diagnostics for zeka, maybe 428 00:26:04,760 --> 00:26:07,520 Speaker 1: the tests that we're now struggling to develop in real time, 429 00:26:07,600 --> 00:26:11,520 Speaker 1: would have already been developed. Even the terrible costs of 430 00:26:11,600 --> 00:26:15,719 Speaker 1: COVID probably won't curb these human tendencies, but more durable 431 00:26:15,800 --> 00:26:19,600 Speaker 1: changes might help. In Arizona, Carmona has been meeting with 432 00:26:19,720 --> 00:26:22,520 Speaker 1: architects trying to figure out how to design buildings with 433 00:26:22,600 --> 00:26:26,399 Speaker 1: wastewater epidemiology in mind. One of their goals is to 434 00:26:26,560 --> 00:26:29,919 Speaker 1: enable future sewage samplers to trace pathogens not just to 435 00:26:30,000 --> 00:26:34,280 Speaker 1: a building, but to individual floors or even rooms. It 436 00:26:34,359 --> 00:26:36,320 Speaker 1: may be what we're going to need in the future, 437 00:26:36,440 --> 00:26:41,760 Speaker 1: Carmona says, we probably will have other biologic hazards. Maybe 438 00:26:41,800 --> 00:26:44,399 Speaker 1: not a pandemic, but it could be an epidemic or 439 00:26:44,440 --> 00:26:46,879 Speaker 1: just an outbreak where you'd like to know where the 440 00:26:46,880 --> 00:26:50,840 Speaker 1: sick people are. That's the cover story in the magazine 441 00:26:50,840 --> 00:26:53,159 Speaker 1: this week, and you can find the magazine on newsstands. 442 00:26:53,160 --> 00:26:55,520 Speaker 1: It's also online at Bloomberg dot com and of course 443 00:26:55,760 --> 00:26:58,840 Speaker 1: on the Bloomberg terminal. I'm Carol Masser and I'm Jason Kelly. 444 00:26:58,880 --> 00:27:01,679 Speaker 1: Check us out every day on the radio are Bloomberg 445 00:27:01,720 --> 00:27:05,119 Speaker 1: Business Week Radio show starts at two pm Wall Street Time, 446 00:27:05,600 --> 00:27:09,160 Speaker 1: Monday through Friday, or check us out on our podcast feed. 447 00:27:09,240 --> 00:27:09,960 Speaker 1: This is Bloomberg