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Speaker 1: Hey, it's Jacob and I've been working on another podcast

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Speaker 1: that's just coming out. It's called Incubation, and it's about viruses.

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Speaker 1: It's about how viruses attack us, how we fight back,

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Speaker 1: and what humanity has learned in the course of fighting

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Speaker 1: with viruses for hundreds of years. In each episode, we'll

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Speaker 1: tell you the story of one virus. The first episode

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Speaker 1: starts with a particularly nasty virus, smallpox. You can listen

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Speaker 1: to Incubation wherever you get your podcasts. Here's the show.

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Speaker 2: I hope you like it.

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Speaker 1: We heard a lot about coronaviruses over the past few years,

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Speaker 1: really a lot, maybe too much, definitely more than we

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Speaker 1: ever expected to hear, but we heard a lot less

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Speaker 1: about other viruses, and viruses are amazing. Viruses are older

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Speaker 1: than animals, they're older than plants. Some scientists thinkviruses may

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Speaker 1: be the origin of all life on Earth. Viruses have

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Speaker 1: been infecting humans, sometimes invisibly, sometimes with terrible consequences, for

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Speaker 1: as long as there have been humans. The story of

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Speaker 1: viruses is the story of humanity's survival as a species,

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Speaker 1: and we're going to tell some of those viral stories

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Speaker 1: on this podcast. I'm Jacob Goldstein and This is Incubation,

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Speaker 1: a show about the other viruses. It's about science and

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Speaker 1: about culture. It's about how viruses attack people and how

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Speaker 1: people fight back. On each episode of Incubation, we're going

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Speaker 1: to tell the story of one virus, and we're starting

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Speaker 1: off with one of the deadliest viruses in history, smallpox.

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Speaker 1: Smallpox stalked humanity for thousands of years. It gave people

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Speaker 1: rashes and blisters all over their bodies, and often it

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Speaker 1: killed them. Smallpox killed hundreds of millions of people, but

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Speaker 1: we humans fought back in profound and brilliant ways. Our

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Speaker 1: episode today starts with the story of Edward Jenner, a

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Speaker 1: doctor in the British countryside, and it ends centuries later

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Speaker 1: with thousands of people working together to wipe smallpox from

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Speaker 1: the face of the earth. My first guest today is

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Speaker 1: Gareth Williams. He's the author of Angel of Death, The

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Speaker 1: Story of Smallpox, and Gareth he knows a lot about

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Speaker 1: Edward Jenner.

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Speaker 3: He was a great fields naturalist, and he also worked

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Speaker 3: at something about the migration of birds, which was completely

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Speaker 3: unknown before that. People thought that swallows went off and

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Speaker 3: hid in mud under riverbanks and things like this.

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Speaker 1: I read that he built a hydrogen balloon that flew

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Speaker 1: twelve miles. That he played the violin, that he wrote poetry.

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Speaker 3: He did only above. He played the flute. I think

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Speaker 3: rather beten. He played the fiddle. He sang, He had

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Speaker 3: a good singing voice. I can recite one of his

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Speaker 3: poems if you'd like it.

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Speaker 1: Of course, give it to my mony.

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Speaker 3: That he wrote it when a man called doctor Weight

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Speaker 3: died and doctor Weight had made medicinal gingerbread biscuits gingerbread nuts,

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Speaker 3: which not only tasted good, but actually killed intestinal worms.

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Speaker 3: Talking about tapeworms and things that round to twenty feet

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Speaker 3: or more. So, here's a put on the death of

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Speaker 3: doctor Weight. It begins with the Latin names of the

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Speaker 3: worms ascarides, tearies, Lumbricki, and all the kyle sucking insects

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Speaker 3: that tremblingly crawl. No more, be afraid you're quite safe

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Speaker 3: in our guts, for Dr Weight has finished making his

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Speaker 3: gingerbread nuts.

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Speaker 1: So in addition to writing poems about nuts, non trivially,

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Speaker 1: Jenner also invented the first vaccine in human history. Let's

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Speaker 1: talk about that. That's really what we're here to talk

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Speaker 1: about today. He's born in seventeen forty nine. He's growing

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Speaker 1: up in England in the you know, second half of

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Speaker 1: the seventeen hundreds. What would his experience of small parks.

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Speaker 3: Have been in Jenna's day? If you got smallpox and

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Speaker 3: you had roughly a one in three chance of getting

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Speaker 3: it during your lifetime, then you had about a one

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Speaker 3: in four chance of being killed by it. He went

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Speaker 3: to boarding school when he was eight. Both his parents

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Speaker 3: had died by then, and he had to be protected

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Speaker 3: against smallpox which had broken out nearby.

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Speaker 1: And this thing happens to him where somebody, if I

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Speaker 1: understand right, cuts open his arm and puts dried out

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Speaker 1: pus from a smallpox patient into the cut on Jenner's arm.

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Speaker 1: What's going on here?

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Speaker 3: This was what was called variolation. And variola is the

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Speaker 3: Latin word for speckled or spotted. It's the old name

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Speaker 3: for smallpox, and it's the name of the virus that

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Speaker 3: causes small pox, of Variola virus. And in brief, variolation

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Speaker 3: was giving healthy people, usually children, the real thing, in

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Speaker 3: the hope that the artificial infection wouldn't kill them, and

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Speaker 3: that it would somehow leave them protected against future attacks

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Speaker 3: of nature re acquired smallpox. It was about a one

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Speaker 3: in fifty mortality, so very very much lower. You got

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Speaker 3: a little bit of small pox puss from one of

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Speaker 3: those revolting blisters that covered people in the tens and thousands,

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Speaker 3: and you would scratch a little bit of that revolting

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Speaker 3: fluid into the skin on the arm of a healthy child.

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Speaker 1: Does it work?

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Speaker 3: It's mad, bad, crazy, dangerous, sounds completely counterintuitive. The amazing

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Speaker 3: thing is it did work, very much so. And the

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Speaker 3: other thing is that if you were vari related, even

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Speaker 3: if you survived while you had your artificial dose of smallpox,

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Speaker 3: you had the real thing. So even though you might

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Speaker 3: get over it in two or three weeks, you could

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Speaker 3: spread it to other non immune people. You had people

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Speaker 3: going back into the community causing little mini outbreaks of

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Speaker 3: small pox and killing lots of other people bi collateral damage.

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Speaker 2: Wow.

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Speaker 1: So okay, So this is the world Jenner is born

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Speaker 1: into the world where you can either get smallpox and

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Speaker 1: a good chance of dying from it if you get it,

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Speaker 1: or if you're sort of lucky in a weird way,

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Speaker 1: you can get violated and have a non trivial chance

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Speaker 1: of getting and dying of small pox and maybe spreading

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Speaker 1: it to other people.

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Speaker 2: That was it.

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Speaker 1: Those were the options. Absolutely, How does he go from

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Speaker 1: being an eight year old boy getting very related to

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Speaker 1: inventing the first vaccine in the world.

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Speaker 3: Okay, if you want the conventional story, yeah.

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Speaker 1: I feel like you're going to give me two stories.

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Speaker 2: What is it?

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Speaker 1: Jenner classic, So give me gener classic.

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Speaker 3: The gender classic is he is a medical apprentice in

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Speaker 3: his early teens and he meets a milkmaid smallpox has

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Speaker 3: reappeared nearby, and she allegedly says to him, look, Gov,

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Speaker 3: you don't need to worry about me having that, because

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Speaker 3: I've had cowpox and that means that I can never

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Speaker 3: ever catch smallpox. And this was complete news to January'd

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Speaker 3: never come across it. But it was also complete news

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Speaker 3: to all his teachers. It simply wasn't part of conventional

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Speaker 3: medical knowledge. It was common knowledge in the farming community.

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Speaker 1: It was folk knowledge that had not sort of crossed

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Speaker 1: over to kind of high brow medical knowledge.

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Speaker 3: A lot of people didn't want to believe it because

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Speaker 3: it had come up from the peasantry.

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Speaker 1: Interesting, so you're saying that's kind of the classic tale.

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Speaker 1: Do you think it's true.

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Speaker 3: I'd like to believe it's true. The alternative story is

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Speaker 3: that one of Jenna's medical colleagues in Thornbury was actually

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Speaker 3: a varulator, very successful one, and he noted, apparently independently,

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Speaker 3: that some people that evarulated the e varulation didn't take.

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Speaker 3: In otherwords, there was no sign that they'd caught this

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Speaker 3: artificial dose of smallpox. And this man was called John Fuster.

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Speaker 3: And story B if you like, is that it was

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Speaker 3: actually Feuster who made the original observation. Jenna was a

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Speaker 3: close friend of his, and Jenna may have decided to

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Speaker 3: pick up on it. Feusa didn't want to pursue it

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Speaker 3: because he was making so much money as a valulator.

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Speaker 3: He didn't see the need for any particular improved.

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Speaker 1: Okay, so Jenner has this idea, whether it's from the

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Speaker 1: milkmaid or from his colleague, this idea that cowpox, which

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Speaker 1: we should say is not a deadly disease in humans, right,

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Speaker 1: can protect humans against a small pox. What does he

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Speaker 1: do with this idea.

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Speaker 3: Well, he doesn't do anything with it for over thirty years.

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Speaker 3: He goes off he finishes his medical studies in London.

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Speaker 3: In seventeen ninety six, he gets the idea of collecting

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Speaker 3: cases of people who've had cowpox and look to see

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Speaker 3: if they appear to be protected against smallpox. And he

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Speaker 3: collects a number of cases and the story appears to

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Speaker 3: be true. And then he moves beyond that to actually

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Speaker 3: test the hypothesis that giving somebody an artificial dose of

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Speaker 3: cowpox will protect them against smallpox. The killer and his

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Speaker 3: first guinea pig is his gardener's son, James Phipps. And

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Speaker 3: the ethics might be regarded as a bit dodgy, because

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Speaker 3: back then, if you were the gardener's son, then you

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Speaker 3: were effectively the property of the lord of the manor.

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Speaker 3: II Jenna, and he introduced cowpox into the arm of

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Speaker 3: James Phipps, who was eight years old. And what Jenna

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Speaker 3: did was to find a case of cowpox with a

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Speaker 3: lovely juicy cowpox bister on the back of her hand.

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Speaker 3: He stuck a lancid in that collected the juice and

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Speaker 3: scratched the cowpox juice into the arm of James Phipps,

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Speaker 3: and that all went well. The lad got a bit

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Speaker 3: of a local reaction, he's got a bit of a fever.

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Speaker 3: Two weeks later he was back to normal. So Jenna

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Speaker 3: now has to test his hypothesis to see if the

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Speaker 3: lad is protected against smallpox. The killer gave him a

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Speaker 3: small dose of smallpox and it didn't take. So that,

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Speaker 3: if you like, was the Eureka moment.

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Speaker 1: So he just invented the first vaccine in the history

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Speaker 1: of the world, a vaccine against maybe the most deadly

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Speaker 1: infectious disease. Truly one of the great discoveries in the

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Speaker 1: history of medicine and the history of public health. What's

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Speaker 1: the first thing he does to try and tell.

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Speaker 3: The world, Well, he writes it all up as a paper,

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Speaker 3: and he sends it off to the Royal Society, and amazingly,

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Speaker 3: the Royal Society reject the paper.

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Speaker 1: They reject his paper, They reject the guy just invented vaccines.

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Speaker 3: Well, they probably wouldn't have appreciated the full significance, but

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Speaker 3: you're right. It is one of the great pinnacle publications

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Speaker 3: in the history of medicine science.

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Speaker 1: But he doesn't give up. What's he doing next?

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Speaker 3: So he writes it up as a pamphlet. It's always

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Speaker 3: known as the Inquiry, okay, and it was published by

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Speaker 3: private printer in Soho came out in September seventeen ninety eight.

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Speaker 3: Jenna did not attempt to hide or make secret his invention.

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Speaker 3: He wanted everybody to know. He wanted everybody to do

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Speaker 3: it because he wanted to conquer smallpox.

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Speaker 1: But you're saying he could also have not published it

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Speaker 1: and just tried to sell vaccination himself and be the

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Speaker 1: sort of soul purveyor of it.

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Speaker 3: That's exactly it. His aim was to spread the words

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Speaker 3: as widely and as quickly as possible. It really takes

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Speaker 3: off and people recognize the value of vaccination immediately, and

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Speaker 3: within a few months, it's on the continent of Europe,

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Speaker 3: it's widespread across England, it's making its appearance in North America.

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Speaker 3: You said within months, within months and months within.

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Speaker 1: This is an era when there's obviously no electronic communication.

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Speaker 1: They're going to have to put the inquiry on a

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Speaker 1: ship and sail it across the ocean. But you're saying

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Speaker 1: it spreads basically immediately.

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Speaker 3: In the absolute absolutely, What do we.

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Speaker 1: Know about, how how many people are being vaccinated, how

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Speaker 1: widespread it is? Like, tell me more about that.

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Speaker 3: Well, it's still the preserve of the rich and wealthy

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Speaker 3: who could afford to pay for medical services, so it's

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Speaker 3: not widespread and philanthropic. But in terms of geographical reach,

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Speaker 3: it is very impressive. It reaches Switzerland very quickly, the Inquiry,

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Speaker 3: which is the King of Spain, and he arranges for

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Speaker 3: the divine gift of vaccination to be sent out to

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Speaker 3: all the Spanish colonies and the Caribbean, South America around

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Speaker 3: the back of the world.

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Speaker 1: So this is all happening in his lifetime, right, He's

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Speaker 1: seeing this happen well.

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Speaker 3: Jenna works very hard actually trying to spread the word.

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Speaker 3: He is always one of the great saints of medicine.

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Speaker 3: But he wasn't a perfect man in any sense, and

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Speaker 3: one of the things that he got wrong quite early

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Speaker 3: was to be able to con himself into thinking that

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Speaker 3: vaccination was absolutely perfect, whereas in fact it did have

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Speaker 3: side effects. For example, you could get a farmyard infection

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Speaker 3: from kylepox having get scratched into your arm. And the

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Speaker 3: other thing was that it needed to be topped.

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Speaker 1: Up, meaning like a booster, you needed what.

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Speaker 3: To absolutely so other countries were giving boosters in the

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Speaker 3: early teenage years, and again if smallpox broke out again,

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Speaker 3: say in Germany, then people nearby would be revaccinated again.

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Speaker 3: So that was one of the things that he got

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Speaker 3: tragically wrong.

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Speaker 1: What's the end of his story?

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Speaker 3: He gets gifts and accolades from all over the world.

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Speaker 3: He gets diamond ring from the Empress of Russia. He

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Speaker 3: spent his declining years, if you like, after his wife died,

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Speaker 3: being the vaccine clerk to the world. That's the way

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Speaker 3: he described himself. He was sitting in his office writing

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Speaker 3: letters back to all the fan mail that poured in

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Speaker 3: from across the world. He was able to look around

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Speaker 3: the world and see a world that was already changing.

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Speaker 1: By the way, how does he come up with the

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Speaker 1: name vaccine?

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Speaker 3: Well, the name was actually coined by somebody else. It's

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Speaker 3: from the Latin vacca meaning cow, and Louis pasteur. When

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Speaker 3: he invented his rabies vaccine and various other vaccines, he

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Speaker 3: suggested that all such immanising or protective preparations should be

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Speaker 3: called vaccines in honor of Jena. So that's why we

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Speaker 3: call them all vaccines today.

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Speaker 1: Thank you for your time. Was a delight to talk

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Speaker 1: with you.

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Speaker 3: Pleasure, Thank you for yours.

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Speaker 1: Edward Jenner died in eighteen twenty three. In the twentieth century,

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Speaker 1: his vaccine would serve as the inspiration for one of

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Speaker 1: the most ambitious public health projects in the history of

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Speaker 1: the world to wipe out every single case of smallpox forever,

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Speaker 1: We'll be right back. In the first half of the

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Speaker 1: twentieth century, Edward Jenner's vaccine continued to spread, but huge

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Speaker 1: swaths of the population remained unvaccinated, and hundreds of millions

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Speaker 1: of people continued to die of smallpox. The world had

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Speaker 1: become smaller and more connected. Air travel was taking off,

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Speaker 1: and smallpox was happy to hitch a ride. Even countries

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Speaker 1: that thought they'd eliminated smallpox found out that they could

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Speaker 1: only keep it at bay for so long.

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Speaker 2: A smallpox scare grips Great Britain, and.

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Speaker 1: Weight of five deaths attributed to the disease that was

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Speaker 1: all but wiped out in Western nations.

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Speaker 2: Tens of thousands throughout the nation line up at health

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Speaker 2: centers to be inoculated. The outbreak of a red.

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Speaker 4: Disease is checked by modern medical science.

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Speaker 1: In the middle of the twentieth century, leaders around the

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Speaker 1: world cooked up an audacious plan to drive the smallpox

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Speaker 1: virus to extinction, to eradicate it from the face of

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Speaker 1: the earth. Donald Hopkins directed the smallpox eradication campaign in

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Speaker 1: Sierra Leone in the late nineteen sixties, just as the

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Speaker 1: global eradication project was getting started. When he arrived in

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Speaker 1: Sierra Leone, the West African nation had the highest smallpox

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Speaker 1: rate in the world. You get to this country, what

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Speaker 1: do you see on the ground?

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Speaker 2: Well, I see, first of all, a beautiful country, and

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Speaker 2: then I'm introduced to the health workers that I'm going

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Speaker 2: to be working with and find that they are very capable,

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Speaker 2: very enthusiastic. I'm young, and very optimistic as well. Yes,

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Speaker 2: people were dying, but the upshot of that was that

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Speaker 2: people were eager. Most people were eager to get vaccinated,

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Speaker 2: and so we did not have a problem of trying

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Speaker 2: to persuade people to cooperate with the program, and that

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Speaker 2: made things a lot easier.

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Speaker 1: Yeah, easier, but this is still a country where there

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Speaker 1: are a lot of places that are just hard to

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Speaker 1: get to, right, I mean, are there any particular instances

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Speaker 1: you remember that were especially challenging.

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Speaker 2: So in the summer of nineteen sixty eight, it's the

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Speaker 2: rainy season in sily Young, we get a message that

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Speaker 2: there is an outbreak in this area southeast of the capital,

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Speaker 2: the area called Moyamba. So I went there with a

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Speaker 2: driver and a couple of the Siri lell and public

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Speaker 2: health workers and the village that we were were summoned

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Speaker 2: to visit, in fact, was about a forty five minute

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Speaker 2: trek from the nearest road. I'm afraid of snakes, and

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Speaker 2: this was a this was a trek through the forest.

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Speaker 1: You're like Indiana Jones. You're wearing a hot.

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Speaker 2: No hat I had. I had a full head of

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Speaker 2: hair then, so I didn't I didn't have to wear

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Speaker 2: a hat. But to beget into this get into this village,

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Speaker 2: and there are lots of people with smallpox, including most

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Speaker 2: notably a newborn infant only a few days old, that

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Speaker 2: was lying on a mat between its mother and the

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Speaker 2: mother's co wife.

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Speaker 1: When you say co wife, what does that mean?

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Speaker 2: That means that they were both married to the same man. Okay,

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Speaker 2: and uh. The child had not been vaccinated, but both

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Speaker 2: of these two women were in the full throws of

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Speaker 2: smallpox infections, and so that infant had been exposed. Fortunately,

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Speaker 2: I had vaccine with me. I was able to vaccinate

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Speaker 2: the infant, and later about ten days later, when I

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Speaker 2: came back, I saw that the vaccination was taking and

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Speaker 2: that baby was saved.

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Speaker 1: And just to just because you know, I've never seen smallpox. Thankfully,

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Speaker 1: when you say that two women were in the throes

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Speaker 1: of infection. What did they look like?

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Speaker 2: Well, it's hard to see people suffering so much, because

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Speaker 2: it's not only that people their bodies are swollen. They're

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Speaker 2: covered in all of these pustules. But it's very painful.

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Speaker 2: People described it as feeling as if your skin was

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Speaker 2: on fire. Smallpox caused a generalized rash over most of

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Speaker 2: the body. It was most intense over the face, the hands,

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Speaker 2: and the feet. But in this instance you could see

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Speaker 2: these raised pimples. First you get little bumps that turn

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Speaker 2: into blisters that then fill with puffs, which then these

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Speaker 2: blisters break, and if you're lucky and survive the broken

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Speaker 2: blisters and puffs, that all drives up and gradually, over

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Speaker 2: the course of two three weeks the scabs drop off.

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Speaker 2: But all of that is infectious, and people when they're

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Speaker 2: just even before the rash starts, when they start feeling

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Speaker 2: headache fever, they're already breathing out smallpox virus onto other people.

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Speaker 2: And so the challenge is the situation like that, to

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Speaker 2: vaccinate as many people who do not yet have smallpox

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Speaker 2: as quickly as you can.

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Speaker 1: So, okay, so you get to this village, you see

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Speaker 1: these two women and the baby. The women are clearly sick.

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Speaker 1: You vaccinate the baby because the smallpox vaccine can actually

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Speaker 1: help people who are in the early stages of an infection.

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Speaker 1: What do you do next? What else is happening in

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Speaker 1: this village?

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Speaker 2: In this census, we learned very quickly that two weeks before,

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Speaker 2: a very prominent man in that village who was head

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Speaker 2: of a secret society, had gotten smallpox and had died.

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Speaker 2: Because he was so prominent, people came from other villages

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Speaker 2: to visit him when he was ill, and people came

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Speaker 2: for his funeral.

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Speaker 1: This is a giant alarm bell. This is very bad

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Speaker 1: news for you in nineteen.

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Speaker 2: Sixty eight, very very bad news, because we also began

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Speaker 2: learning when I was there. What we were seeing was

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Speaker 2: that many people had come from other villages as well

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Speaker 2: surrounding this village, and so this was a much bigger

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Speaker 2: outbreak than what we were expecting.

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Speaker 1: So tell me about what containment meant at this time

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Speaker 1: in this context.

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Speaker 2: Yes, when we first began working in the smallpox program,

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Speaker 2: the strategy was to mass vaccinate eighty percent or more

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Speaker 2: of the population. The containment surveillance strategy was developed where

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Speaker 2: the strategy became find out where the current cases of

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Speaker 2: smallpox are go there, give priority to vaccinating people in

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Speaker 2: those households and that village and nearby villages. So called

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Speaker 2: ring vaccination, because if you could do that, you could

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Speaker 2: stop the virus from spreading to other people. That was

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Speaker 2: a much more efficient way of getting after the virus

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Speaker 2: to stop transmission, because now you're looking to vaccinate three

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Speaker 2: four five percent of the population rather than eighty percent

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Speaker 2: of the population.

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Speaker 1: It's like you draw a circle, a big circle around

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Speaker 1: the village where the infection is, and you vaccinate everybody

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Speaker 1: inside that circle. So it's like you're surrounding the virus

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Speaker 1: with immune people.

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Speaker 2: That's exactly what you're doing. And the radius of that

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Speaker 2: circle was at least five miles.

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Speaker 1: Okay, so you have your information right, you have your

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Speaker 1: epidemiological surveillance, you have your your ring on a map.

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Speaker 1: What do you do?

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Speaker 2: We then come back with several other vaccinators and have

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Speaker 2: a plan to assign different groups to go to each

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Speaker 2: of these villages and make sure that everyone there is vaccinated.

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Speaker 1: And you just show up in a village with your

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Speaker 1: briefcase full of a vaccine and say here we are

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Speaker 1: come line up.

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Speaker 2: The villagers had had warning, and in fact, we discussed

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Speaker 2: with the village chief and the senior people in the

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Speaker 2: village to agree on a mutual time when was most

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Speaker 2: convenient for them for us to come back and make

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Speaker 2: sure everybody was vaccinated. You had to give them notice

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Speaker 2: in advance, because otherwise, if you just show up, people

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Speaker 2: are out on the farms, which could be two or

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Speaker 2: three miles away in many different directions, et cetera.

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Speaker 1: So how long does it take you to with your

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Speaker 1: team go to all of the villages inside this ring

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Speaker 1: and vaccinate everybody.

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Speaker 2: That took a matter of a few days fast. So

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Speaker 2: each team only had to go to one or two villages,

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Speaker 2: and so we were able to get there in a

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Speaker 2: few days and get them vaccinated, and we were able

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Speaker 2: to stop that particular outbreak in only three or four

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Speaker 2: weeks max.

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Speaker 4: Wow.

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Speaker 1: So it worked.

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Speaker 2: It worked. It not only worked in Sierra Leone, but

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Speaker 2: when we sent a telegram back to CDC headquarters to

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Speaker 2: let them know what had happened, they were ecstatic. And

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Speaker 2: of course, this was one of the first big demonstrations

410
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Speaker 2: of the power of this new ring vaccination strategy, and

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Speaker 2: so it electrified the entire global smallpox eradication program to

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Speaker 2: see that this worked so well in Sierra Leone, which

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Speaker 2: had so much smallpox.

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Speaker 1: So we have the good news. What did you do next?

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Speaker 1: How long were you in Ciri Leone? What happened next?

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Speaker 2: I was in Siri Leone for a total of two years,

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Speaker 2: that was. I left Sierra Leone in August of nineteen

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Speaker 2: sixty nine. Smallpox was gone from Sierra Leone by April

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Speaker 2: May of nineteen sixty nine.

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Speaker 1: So by the time you left, you and your team

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Speaker 1: had eradicated smallpox from one of the worst affected countries

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Speaker 1: in the world.

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Speaker 2: Exactly, And that was a big exclamation point. I was

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Speaker 2: then forever optimistic that smallpox was gonna go. It was

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Speaker 2: then to me just a matter of time.

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Speaker 1: It's really striking to me that we, or you, you

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Speaker 1: and your colleagues eradicated smallpox more than forty years ago now,

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Speaker 1: and we humanity, I haven't succeeded in eradicating anything else yet.

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Speaker 1: I know we're getting close on polio, but we've been

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Speaker 1: close on polio for a while, and yes, it's not

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Speaker 1: gone yet. Was smallpox unanomaly.

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Speaker 2: Yes, smallpox is anomaly. Unfortunately, nothing else is like smallpox

433
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Speaker 2: eradication means you have to get to whatever disease you're

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Speaker 2: targeting everywhere wherever it exists, and it's going to exist

435
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Speaker 2: in some places where it's a big problem, people care

436
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Speaker 2: about it, they're motivated to work against it. But it's

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Speaker 2: also going to exist in some areas where it's a

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Speaker 2: trivial problem, where people have much bigger things to worry

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Speaker 2: about than that targeted disease. But you're going to have

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Speaker 2: to get them on board as well, because as long

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Speaker 2: as it exists anywhere, it's unsafe for people everywhere.

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Speaker 1: Doctor, it was a real delight to talk to you.

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Speaker 1: Let me say thank thank you for your work. I'm

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Speaker 1: very grateful to live in a world with no smallpox.

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Speaker 2: Well, thank you, I'm i am too.

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Speaker 1: Donald Hopkins is currently the Special Advisor for guinea worm

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Speaker 1: eradication at the Carter Center. Thanks to my guest today

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Speaker 1: Gareth Williams and Donald Hopkins. Next week we'll tell the

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Speaker 1: story of the race for the polio vaccine, and we'll

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Speaker 1: try to figure out why polio and other viruses have

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Speaker 1: turned out to be so much harder to eradicate than smallpox.

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Speaker 4: We need to ensure that we have full momentum for

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Speaker 4: this last push, the final push to reach that last

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Speaker 4: child in that last village of these areas.

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Speaker 1: Incubation is a co production of Pushkin Industries and Ruby

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Speaker 1: Studio at iHeartMedia. It's produced by Gabriel Hunter Chang, Ariela Markowitz,

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Speaker 1: and Amy Gaines McQuaid. Our editors are Julia Barton and

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Speaker 1: Karen SCHAKERJI mastering by Anne Pope, fact checking by Joseph Fridman,

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Speaker 1: our executive. Our producers are Katherine Girardeau and Matt Romano.

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Speaker 1: I'm Jacob Goldstein. Thanks for listening.