WEBVTT - What is the Physics of life?

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<v Speaker 5>Daniel, it's good to see you. I have a question

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<v Speaker 5>that I have been dying to ask you. When is

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<v Speaker 5>physics going to unravel the deep mysteries of the universe?

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<v Speaker 1>Wow? Right into it? Huh. Unfortunately we don't have that

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<v Speaker 1>on our schedule exactly, and it's going to be as

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<v Speaker 1>long as it takes.

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<v Speaker 3>You know what.

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<v Speaker 5>I need to do something important, but I keep putting

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<v Speaker 5>it off. I put it on a calendar and give

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<v Speaker 5>myself a deadline. I find that that actually makes it happen.

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<v Speaker 5>So you should schedule it.

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<v Speaker 1>All right, let's do it. I'm putting it on my calendar.

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<v Speaker 1>Let's have a zoom meeting to share our ultimate enlightenment

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<v Speaker 1>about the universe. Have about June twenty twenty nine that

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<v Speaker 1>worked for you?

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<v Speaker 6>Uh?

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<v Speaker 4>You know?

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<v Speaker 5>I feel like when you come up with budgets and timelines,

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<v Speaker 5>you always need to multiply by at least three. So

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<v Speaker 5>let's do something in the twenty forties, and I think

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<v Speaker 5>you'll have enough time then so there it's scheduled, and

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<v Speaker 5>that was easy.

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<v Speaker 1>Yeah. Well, you know now I'm worried that scheduling our

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<v Speaker 1>ultimate enlightenment is going to lead us right into the

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<v Speaker 1>Hitchhiker's Guide to the Universe.

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<v Speaker 3>Trap, like I'm gonna forget my towel.

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<v Speaker 1>That maybe, but more importantly, we might get the answer

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<v Speaker 1>and have no idea what the question was.

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<v Speaker 3>Yep, yep, that's a tough one.

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<v Speaker 7>Hi.

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<v Speaker 1>I'm Daniel. I'm a particle physicist and a professor at

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<v Speaker 1>u C Irvine, and I never forget my towel.

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<v Speaker 5>I'm Kelly Waidersmith, and my kids are always annoyed with

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<v Speaker 5>me because I'm the only mom at the pool who

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<v Speaker 5>always forgets the towels. And I'm a junct faculty at

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<v Speaker 5>Race University.

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<v Speaker 1>How can you be forgetting towels? I mean, you have

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<v Speaker 1>these young kids, they're always making messes. I mean everybody's kids,

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<v Speaker 1>not yours a particular. You gotta just learn to bring

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<v Speaker 1>the towel wherever you go.

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<v Speaker 5>Right, I am resistant to learning. I guess I should

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<v Speaker 5>know by now, but I never All the other moms

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<v Speaker 5>have the big bags and they've got snacks and goldfish.

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<v Speaker 5>My kids are always like, where are the goldfish? Everybody

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<v Speaker 5>else has goldfish, and I'm like, tell it to your

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<v Speaker 5>shrinking a couple of years kid, I'm sorry.

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<v Speaker 1>At least I have something to complain about, right. My

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<v Speaker 1>wife has one of those big bags, but she doesn't

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<v Speaker 1>just have snacks and goldfish in it. She's got all

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<v Speaker 1>sorts of random crap in there. And my kids are

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<v Speaker 1>always making fun of her for it until the moment

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<v Speaker 1>where they're like, hey, mom, wait, do you have chapstick

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<v Speaker 1>or do you have a spoon And she's like, of

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<v Speaker 1>course I do, and she digs it out of a

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<v Speaker 1>bag and then she's like the savior.

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<v Speaker 3>Mom to the rescue.

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<v Speaker 1>Are the best, absolutely and so Welcome to the podcast

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<v Speaker 1>that celebrates moms but also asks the deepest questions in

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<v Speaker 1>the universe. We want to know how everything works, where

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<v Speaker 1>it all came from, how it all can possibly make

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<v Speaker 1>sense to our squishy little brains. Welcome to Daniel and

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<v Speaker 1>Jorge Explain the Universe, a production of iHeartRadio.

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<v Speaker 5>So today we're going to be talking about a topic

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<v Speaker 5>that's near and dear to my heart. I've spent many

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<v Speaker 5>hours arguing over this question with friends, but I'll let

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<v Speaker 5>you go.

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<v Speaker 3>Ahead and introduce it. I'm just just wanting to preface

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<v Speaker 3>that I'm excited.

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<v Speaker 1>On this podcast, we talk about some of the deepest

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<v Speaker 1>questions in the universe. How is everything made? Where it

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<v Speaker 1>all come from? What are the tiny little quantum particles,

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<v Speaker 1>how do they weave themselves together in order to explain

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<v Speaker 1>this existence? And where possibly did we leave our towels.

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<v Speaker 1>But today in the podcast, we're going to talk about

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<v Speaker 1>something maybe even deeper, something much more personal, something closer

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<v Speaker 1>to our experience, and that's the question of life itself.

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<v Speaker 1>What is it? How, how can we talk about it,

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<v Speaker 1>how can we understand it? And how possibly could we

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<v Speaker 1>discover it on alien planets?

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<v Speaker 3>Oh, there's nothing better than talking about biology on a

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<v Speaker 3>physics podcast. Finally get into the good stuff.

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<v Speaker 1>With a couple of physicists, right, And so today on

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<v Speaker 1>the podcast, we're going to be digging into the question

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<v Speaker 1>what is the physics of life? And we're gonna be

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<v Speaker 1>talking to Professor Sarah Amari Walker, author of the recent

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<v Speaker 1>book Life As No One Knows It, The Physics of

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<v Speaker 1>Life's Emergence. How do you feel about talking about life

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<v Speaker 1>with two physicists.

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<v Speaker 3>Kelly wouldn't be my first choice. But no, I'm kidding.

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<v Speaker 5>I mean I'm very excited to hear a different perspective

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<v Speaker 5>on the question.

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<v Speaker 1>Well, I hope you brought a towel, because this is

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<v Speaker 1>gonna be messy. It's always fascinating when physicists try to

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<v Speaker 1>walk into another field and explain things. And I feel

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<v Speaker 1>like often we do that because we think maybe there

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<v Speaker 1>is a simpler explanation, or because we think in these

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<v Speaker 1>like fundamental grounding in the basic principles of the universe.

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<v Speaker 1>How would you say, that's typically receives Kelly.

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<v Speaker 5>So you say fascinating, we say maddening, because so often physicists,

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<v Speaker 5>you know, seem to think that physics is up here

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<v Speaker 5>and biology is a few levels below, and if you

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<v Speaker 5>know physics, you must also know biology and maybe also chemistry,

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<v Speaker 5>so you can just wade in and solve all the

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<v Speaker 5>problems that the biologists are too silly to be able

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<v Speaker 5>to figure out. And so often there's you know, a

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<v Speaker 5>bit of condescension in the answers. I saw Freeman Dyson

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<v Speaker 5>give a talk once about group selection that was absolutely infuriating,

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<v Speaker 5>but because he clearly didn't understand what we were actually

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<v Speaker 5>arguing about. But anyway, today's conversation. You know, I read

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<v Speaker 5>life as No One Knows It by our author who

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<v Speaker 5>we're talking to today, and I really appreciated that she

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<v Speaker 5>did not have that condescending biology as easy attitude. She

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<v Speaker 5>clearly appreciated the nuances and was trying to meld it

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<v Speaker 5>with physics.

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<v Speaker 1>As a physicist married to a biologist, I've definitely learned

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<v Speaker 1>to treat biology with great respect good and not just

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<v Speaker 1>for the health of my marriage, but also just intellectually

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<v Speaker 1>because I appreciate it. And I think, you know, the

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<v Speaker 1>dirty secret about physicists walking into biology or chemistry is

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<v Speaker 1>that we became physicists not because we thought biology was

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<v Speaker 1>too easy. Your chemistry was too simple, but because it's

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<v Speaker 1>too hard. You know, we can think about simple objects

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<v Speaker 1>and put them together to try to describe the fundamental

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<v Speaker 1>nature of the universe, but now we need like ten

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<v Speaker 1>to the forty objects to explain like a drop of rain.

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<v Speaker 1>It's too complicated. I can't think about all of those

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<v Speaker 1>things at once. That's why I let to boil things down,

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<v Speaker 1>for like, one particle touches one other particle, and that's

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<v Speaker 1>my whole universe.

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<v Speaker 3>Man.

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<v Speaker 5>I appreciate that you're trying to clean up the reputation

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<v Speaker 5>for your community. But I don't buy it at all.

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<v Speaker 5>But I do think that biology is complicated. You know,

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<v Speaker 5>we got the human microbiome that didn't solve all the

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<v Speaker 5>disease related problems we thought it was going to solve.

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<v Speaker 5>Now we're working on the connect dome for the brain

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<v Speaker 5>and there's just many levels.

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<v Speaker 3>Man, it's complicated. We deserve respect.

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<v Speaker 1>Maybe one day we'll have an explanation for the human

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<v Speaker 1>brain that goes all the way down to the fundamental physics,

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<v Speaker 1>but not yet. And so to take us on this

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<v Speaker 1>journey through the physics of life, whether we can understand

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<v Speaker 1>the nature of life, the meaning of life, how to

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<v Speaker 1>look for life, and how maybe even to discover life

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<v Speaker 1>on alien planets. We had a fun conversation with Professor

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<v Speaker 1>Sarah Amari Walker about her new book Life As No

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<v Speaker 1>One Knows It. Here's the interview. So then it's my

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<v Speaker 1>pleasure to welcome the podcast Sarah and Mauri Walker. She's

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<v Speaker 1>a theoretical physicist and deputy director for the Beyond Center

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<v Speaker 1>for Fundamental Concepts and Science, as well as a professor

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<v Speaker 1>at Arizona State University, and she's tackling some really hard

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<v Speaker 1>questions about the nature of life and consciousness and free

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<v Speaker 1>will using physics in her new book, Sarah, thank you

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<v Speaker 1>very much for joining us today.

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<v Speaker 8>Yeah, I'm terrilled to be here. Thanks for having me.

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<v Speaker 3>We're so glad to have you here.

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<v Speaker 1>So before we dig into the topic of your book,

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<v Speaker 1>I just wanted to get to know you a little

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<v Speaker 1>bit better, especially because you're writing such a fascinating book.

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<v Speaker 1>You're tackling really big, really hard, almost philosophical questions, but

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<v Speaker 1>you're using physics as a tool to do it. So

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<v Speaker 1>take us back to the beginning, like what got you

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<v Speaker 1>into physics in the first place.

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<v Speaker 6>I did not know I wanted to be a physicist

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<v Speaker 6>until I took my first physics class. So most of

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<v Speaker 6>my childhood I actually thought I was going to be

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<v Speaker 6>an artist. And I went to community college and I

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<v Speaker 6>knew at the time I liked science, so I just

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<v Speaker 6>took all the science classes i could, and I just

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<v Speaker 6>fell in love with physics. I just think it's absolutely

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<v Speaker 6>amazing to think about the universe in these really deep,

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<v Speaker 6>abstract ways and come to understand the world in a

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<v Speaker 6>way that is almost existentially shocking to humans in some sense,

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<v Speaker 6>because it's so different than the way that we thought

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<v Speaker 6>it was, and the set of broad regularities that physics

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<v Speaker 6>reveals I think are really beautiful, And I guess I

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<v Speaker 6>was really excited about transforming something about the way that

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<v Speaker 6>we think about the world and the way that physics

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<v Speaker 6>does that.

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<v Speaker 8>So I decided I wanted to be a physicist.

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<v Speaker 1>Awesome. So we just had an episode recently about thinking

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<v Speaker 1>like a physicist what that means, and had a little

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<v Speaker 1>disagreement with Jorge about whether physicists think differently than other scientists.

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<v Speaker 1>And so you say you're drawn to physics in particular

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<v Speaker 1>because of the way they think about the world. How

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<v Speaker 1>is that different? How does a physicist think about the

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<v Speaker 1>universe different than a biologist?

0:11:25.120 --> 0:11:27.080
<v Speaker 6>Yeah, and I'm not even sure if it comes down

0:11:27.120 --> 0:11:29.560
<v Speaker 6>to training or who gets attracted to different fields. So

0:11:29.559 --> 0:11:32.360
<v Speaker 6>I actually asked this question myself. But for me, I

0:11:32.400 --> 0:11:34.560
<v Speaker 6>think a lot of the discussion about what physics is

0:11:34.559 --> 0:11:37.000
<v Speaker 6>is mostly about what physics studies and not what physics

0:11:37.000 --> 0:11:39.520
<v Speaker 6>is as a discipline. And so for me, when I

0:11:39.559 --> 0:11:41.360
<v Speaker 6>think about the history of physics and also what I'm

0:11:41.360 --> 0:11:44.400
<v Speaker 6>trying to do as a physicist, moving into territory that's

0:11:44.400 --> 0:11:48.280
<v Speaker 6>traditionally not thought of as physics. You know, the thread

0:11:48.320 --> 0:11:50.719
<v Speaker 6>I see there that I think is the commonality of

0:11:50.800 --> 0:11:53.240
<v Speaker 6>like what I think the core of physics is is

0:11:53.360 --> 0:11:58.200
<v Speaker 6>building new and abstract explanations for the world around us.

0:11:58.280 --> 0:12:00.360
<v Speaker 6>So I think physics to me is getting to like

0:12:00.400 --> 0:12:03.320
<v Speaker 6>the very root of like the most fundamental explanations, and

0:12:03.320 --> 0:12:07.720
<v Speaker 6>that process of doing that is you know, very unique

0:12:08.160 --> 0:12:11.199
<v Speaker 6>to physics, I think is a discipline relative to other sciences.

0:12:11.240 --> 0:12:13.160
<v Speaker 6>I think other sciences also do that, but I think

0:12:13.160 --> 0:12:14.760
<v Speaker 6>the kind of training and the way that we're taught

0:12:14.760 --> 0:12:17.840
<v Speaker 6>to think and trying to embed these sort of abstract

0:12:17.920 --> 0:12:23.920
<v Speaker 6>universal ideas in mathematics that are so broad, is pretty.

0:12:23.640 --> 0:12:25.960
<v Speaker 8>Unique to what we call physics.

0:12:26.000 --> 0:12:27.720
<v Speaker 6>Now, whether it will stay that way and it doesn't

0:12:27.720 --> 0:12:29.760
<v Speaker 6>become sort of more universal to the rest of science,

0:12:29.840 --> 0:12:31.640
<v Speaker 6>or even if that's the best way of doing science,

0:12:31.679 --> 0:12:33.000
<v Speaker 6>as you know, a whole other.

0:12:32.880 --> 0:12:33.640
<v Speaker 8>Subject of debate.

0:12:33.679 --> 0:12:36.360
<v Speaker 6>But for me, that's the essence of what physics is

0:12:36.360 --> 0:12:39.559
<v Speaker 6>and why I still identify as a physicist, even though

0:12:39.600 --> 0:12:42.319
<v Speaker 6>the problems I study are so different than what has

0:12:42.360 --> 0:12:44.400
<v Speaker 6>traditionally been studied in physics.

0:12:45.000 --> 0:12:48.520
<v Speaker 5>When you've taken on a particularly in my mind, complicated

0:12:48.679 --> 0:12:52.359
<v Speaker 5>questions to tackle, so my training is as a biologist

0:12:52.400 --> 0:12:55.240
<v Speaker 5>and in grad school, like the thing that you stay

0:12:55.280 --> 0:12:58.439
<v Speaker 5>up late drinking and talking about is you know what

0:12:58.559 --> 0:13:02.120
<v Speaker 5>is life? And how do you define species? Those are

0:13:02.160 --> 0:13:04.760
<v Speaker 5>like the two questions where at the end we're all like,

0:13:04.920 --> 0:13:07.520
<v Speaker 5>I don't know. Nature doesn't fit into categories, and we

0:13:07.600 --> 0:13:10.440
<v Speaker 5>all laugh and go out dancing. And so what different

0:13:10.480 --> 0:13:12.920
<v Speaker 5>perspective does a physicist have on that question? And why

0:13:12.920 --> 0:13:14.960
<v Speaker 5>do we need an answer to this question as opposed

0:13:14.960 --> 0:13:18.120
<v Speaker 5>to the hand wavy nature doesn't fit into nice categories,

0:13:18.200 --> 0:13:18.880
<v Speaker 5>let's just move on.

0:13:19.040 --> 0:13:20.680
<v Speaker 3>Why do we need to do better than that?

0:13:21.040 --> 0:13:24.319
<v Speaker 6>So I love the resolution that nature doesn't fit into categories,

0:13:25.000 --> 0:13:27.400
<v Speaker 6>and so I love that that's like part of the conclusion.

0:13:27.400 --> 0:13:29.679
<v Speaker 6>I think that's actually a brilliant insight, because I think

0:13:29.679 --> 0:13:32.160
<v Speaker 6>we have a tendency to put problems in boxes, because

0:13:32.200 --> 0:13:35.440
<v Speaker 6>certain disciplines might become more adept to answering certain aspects

0:13:35.480 --> 0:13:38.320
<v Speaker 6>of questions. But there are some questions on the frontier,

0:13:38.400 --> 0:13:41.360
<v Speaker 6>like what is life that you know as a biologist,

0:13:41.480 --> 0:13:43.280
<v Speaker 6>Maybe you don't need to know the answer to you

0:13:43.360 --> 0:13:45.800
<v Speaker 6>because you can study biology on Earth without ever having

0:13:45.840 --> 0:13:49.440
<v Speaker 6>a resolution to that question. But this gets to your

0:13:49.480 --> 0:13:52.679
<v Speaker 6>point that you know there are some questions like the

0:13:52.720 --> 0:13:56.080
<v Speaker 6>origin of life that require an understanding of what life is,

0:13:56.080 --> 0:13:58.880
<v Speaker 6>because that is not even a precisely defined question unless

0:13:59.440 --> 0:14:02.479
<v Speaker 6>we say that there's some category of nature quote unquote

0:14:02.520 --> 0:14:04.839
<v Speaker 6>that is life that we're trying to explain the origin of,

0:14:05.480 --> 0:14:08.439
<v Speaker 6>and the other one is alien life. Are designing completely

0:14:08.600 --> 0:14:10.520
<v Speaker 6>radically new kinds of life, which I think are not

0:14:10.640 --> 0:14:13.480
<v Speaker 6>really decoupled problems with this idea of like what other

0:14:13.559 --> 0:14:15.840
<v Speaker 6>forms could life take besides the ones that have evolved

0:14:15.880 --> 0:14:17.960
<v Speaker 6>on Earth, besides the biology that we know it?

0:14:18.600 --> 0:14:19.800
<v Speaker 8>And so I think.

0:14:19.680 --> 0:14:24.800
<v Speaker 6>Those questions, surprisingly enough, don't seem to have answers that

0:14:24.880 --> 0:14:28.200
<v Speaker 6>fall just within the discipline of biology as it's developed,

0:14:28.240 --> 0:14:30.480
<v Speaker 6>because of exactly what you're pointing out, that the boundaries

0:14:30.520 --> 0:14:33.720
<v Speaker 6>of disciplines are kind of historically contingent, and there's a

0:14:33.720 --> 0:14:36.720
<v Speaker 6>lot of things that necessarily need to come from chemistry

0:14:36.760 --> 0:14:38.680
<v Speaker 6>or even computer science or physics or all these other

0:14:38.720 --> 0:14:42.000
<v Speaker 6>different disciplines. And so one thing I've really come to

0:14:42.040 --> 0:14:44.560
<v Speaker 6>notice in my career is that whatever discussion we need

0:14:44.600 --> 0:14:46.880
<v Speaker 6>to have about solving that problem doesn't fit in any

0:14:46.920 --> 0:14:49.960
<v Speaker 6>discipline as it's currently structured, And in some sense we

0:14:50.080 --> 0:14:51.840
<v Speaker 6>might need to build a new discipline to really think

0:14:51.880 --> 0:14:54.920
<v Speaker 6>about this problem because it's beyond the boundaries of like

0:14:54.960 --> 0:14:58.080
<v Speaker 6>the current confines of knowledge that we've defined them so far.

0:14:58.720 --> 0:15:01.359
<v Speaker 6>And that's exciting because it just shows you that disciplines

0:15:01.400 --> 0:15:02.320
<v Speaker 6>are kind of.

0:15:02.280 --> 0:15:05.040
<v Speaker 8>Human centric categories of nature. We might have to rewrite them.

0:15:05.840 --> 0:15:08.320
<v Speaker 1>Yeah, I mean, we might argue, like, what is a

0:15:08.360 --> 0:15:09.360
<v Speaker 1>physicist anyway?

0:15:09.640 --> 0:15:13.200
<v Speaker 6>And people exactly about that, right, and just redefine that

0:15:13.400 --> 0:15:13.960
<v Speaker 6>term too.

0:15:14.440 --> 0:15:15.200
<v Speaker 8>That sounds good to me.

0:15:16.520 --> 0:15:19.560
<v Speaker 1>And you begin your really fun book with this question

0:15:20.000 --> 0:15:23.920
<v Speaker 1>and the sort of shocking suggestion that somebody made that

0:15:23.960 --> 0:15:27.520
<v Speaker 1>life doesn't exist. You know that if we can't categorize it,

0:15:27.560 --> 0:15:29.800
<v Speaker 1>if we can't define it, then maybe it doesn't exist

0:15:30.800 --> 0:15:34.240
<v Speaker 1>in the end. What is your definition of life?

0:15:34.760 --> 0:15:35.080
<v Speaker 8>Yeah?

0:15:35.120 --> 0:15:38.720
<v Speaker 6>So in my mind I usually keep I think a

0:15:38.800 --> 0:15:41.960
<v Speaker 6>running list of maybe three to ten different definitions for life,

0:15:42.000 --> 0:15:44.640
<v Speaker 6>because I think pinning yourself to one too early is

0:15:44.680 --> 0:15:47.680
<v Speaker 6>a bit premature when we don't understand what we're talking about.

0:15:47.720 --> 0:15:50.880
<v Speaker 8>So usually my process is, you know, I really want to.

0:15:51.080 --> 0:15:54.800
<v Speaker 6>Have a theory, like a theory that explains the broad

0:15:54.960 --> 0:15:57.840
<v Speaker 6>patterns and regularities that we see across living forms and

0:15:58.040 --> 0:16:00.200
<v Speaker 6>is deep enough to help us understand the original life.

0:16:00.200 --> 0:16:03.560
<v Speaker 6>That's sort of my modality of thinking about these problems,

0:16:04.120 --> 0:16:06.440
<v Speaker 6>and so I've spent most of my career trying to

0:16:06.480 --> 0:16:08.240
<v Speaker 6>figure out what the structure of such a theory would be.

0:16:08.280 --> 0:16:10.280
<v Speaker 6>And obviously it has to be guided by some concept

0:16:10.280 --> 0:16:12.200
<v Speaker 6>of what you think life is. So it's a little circular,

0:16:12.240 --> 0:16:16.440
<v Speaker 6>but you're constantly redefining everything. So I'm often very hesitant

0:16:16.520 --> 0:16:18.960
<v Speaker 6>to pin one answer when people.

0:16:18.760 --> 0:16:20.080
<v Speaker 8>Ask me what I think life is.

0:16:21.080 --> 0:16:24.440
<v Speaker 6>But with all that caveat, I can give you kind

0:16:24.440 --> 0:16:27.520
<v Speaker 6>of a conceptual framing of what I think it is,

0:16:27.560 --> 0:16:30.160
<v Speaker 6>but I wouldn't want to call it a definition. And

0:16:30.240 --> 0:16:32.280
<v Speaker 6>I think a lot of what the theory that we're

0:16:32.320 --> 0:16:34.240
<v Speaker 6>working on in the kinds of experiments are pointing to

0:16:34.360 --> 0:16:38.600
<v Speaker 6>is that life is something about how information structures mattercross

0:16:38.600 --> 0:16:40.080
<v Speaker 6>space and time is one way I say it, But

0:16:40.120 --> 0:16:42.600
<v Speaker 6>I think in the theory that we're building, it's much

0:16:42.600 --> 0:16:45.240
<v Speaker 6>more precise to say that life is the mechanism by

0:16:45.240 --> 0:16:47.680
<v Speaker 6>which the universe generates complexity. And we have a very

0:16:47.680 --> 0:16:50.080
<v Speaker 6>specific way of thinking about complexity, and it becomes very

0:16:50.280 --> 0:16:53.800
<v Speaker 6>historically contingent, and so I guess how the universe uses

0:16:53.920 --> 0:16:56.960
<v Speaker 6>memory that builds complex things in the future might be

0:16:56.960 --> 0:16:58.520
<v Speaker 6>the way I say it today, and if you ask

0:16:58.560 --> 0:17:00.480
<v Speaker 6>me tomorrow, I would say something else, because we're still

0:17:00.560 --> 0:17:02.200
<v Speaker 6>a work in progress about trying to get to the

0:17:02.240 --> 0:17:04.399
<v Speaker 6>bottom of what it is we're actually talking about.

0:17:04.480 --> 0:17:08.200
<v Speaker 5>So for a biologists, the argument almost always comes down to, well,

0:17:08.200 --> 0:17:11.160
<v Speaker 5>our virus is alive or not, so using the definition

0:17:11.200 --> 0:17:14.480
<v Speaker 5>that you just gave our viruses alive or not and why.

0:17:14.600 --> 0:17:17.320
<v Speaker 8>Yeah, So I think there's a little bit more nuanced.

0:17:17.359 --> 0:17:18.879
<v Speaker 6>So usually the way I talk about it is like,

0:17:18.920 --> 0:17:21.000
<v Speaker 6>are we talking about the physics of life? Are particular

0:17:21.000 --> 0:17:23.879
<v Speaker 6>instances of things that are living? And it might be like,

0:17:24.000 --> 0:17:27.040
<v Speaker 6>are you talking about gravitational physics and like the curvature

0:17:27.119 --> 0:17:28.879
<v Speaker 6>or space time, or are you talking about a gravitational

0:17:28.880 --> 0:17:32.040
<v Speaker 6>body that was generated by these sort of fundamental mechanisms

0:17:32.040 --> 0:17:33.560
<v Speaker 6>that we know that our universe works in. And I

0:17:33.600 --> 0:17:37.400
<v Speaker 6>think there are slightly different categories. So when I say

0:17:37.440 --> 0:17:40.040
<v Speaker 6>things are life, I mean anything that is the product

0:17:40.080 --> 0:17:44.960
<v Speaker 6>of an evolutionary process and requires memory and information from

0:17:45.000 --> 0:17:47.600
<v Speaker 6>the past to be able to actually make that thing

0:17:47.680 --> 0:17:50.640
<v Speaker 6>exist in the present. And I think viruses are certainly

0:17:50.760 --> 0:17:54.720
<v Speaker 6>that they require evolution to form, but the sort of

0:17:54.800 --> 0:17:58.679
<v Speaker 6>active process of generating complexity and generating novelty and contributing

0:17:58.680 --> 0:18:01.800
<v Speaker 6>to the sort of open end growth of complexity that

0:18:01.800 --> 0:18:04.280
<v Speaker 6>we've observed in our biosphere. I think things that do

0:18:04.359 --> 0:18:06.880
<v Speaker 6>that are alive. And I'm not sure that I would

0:18:06.920 --> 0:18:10.239
<v Speaker 6>qualify a virus as an individual agent as part of

0:18:10.240 --> 0:18:12.520
<v Speaker 6>that creative process, but it certainly is when you look

0:18:12.560 --> 0:18:16.600
<v Speaker 6>at viruses as components of ecological systems for example. So

0:18:16.720 --> 0:18:18.760
<v Speaker 6>a lot of the things with issues about life is

0:18:18.800 --> 0:18:21.320
<v Speaker 6>trying to pick a scale and say this thing is life,

0:18:21.359 --> 0:18:24.119
<v Speaker 6>when really what you're talking about is a much more

0:18:24.200 --> 0:18:27.440
<v Speaker 6>abstract universal physics that even enables those things to exist

0:18:27.440 --> 0:18:29.679
<v Speaker 6>in the first place, to be selected. I think the

0:18:29.720 --> 0:18:32.159
<v Speaker 6>reason that viruses have been hard is because it's actually

0:18:32.160 --> 0:18:34.760
<v Speaker 6>a category error to try to partition a boundary and

0:18:34.760 --> 0:18:36.439
<v Speaker 6>around a virus and say is this alive or not

0:18:36.520 --> 0:18:38.399
<v Speaker 6>when you really should be looking at the continuity of

0:18:38.400 --> 0:18:40.520
<v Speaker 6>the evolutionary process and what it constructs.

0:18:40.840 --> 0:18:44.840
<v Speaker 1>Yeah. Fascinating. I don't know that I agree that we

0:18:45.000 --> 0:18:48.320
<v Speaker 1>need a definition of life, but I do think it's

0:18:48.480 --> 0:18:51.600
<v Speaker 1>valuable to try, Like, I think we need to have

0:18:51.640 --> 0:18:53.480
<v Speaker 1>the discussion in order to try to figure out what

0:18:53.560 --> 0:18:57.159
<v Speaker 1>this is. Like if we agree or discuss, you know

0:18:57.200 --> 0:18:59.320
<v Speaker 1>what life is that shapes the way we think about

0:18:59.359 --> 0:19:01.879
<v Speaker 1>how to look for alien life and all these questions.

0:19:01.920 --> 0:19:04.119
<v Speaker 1>So I think it's very valuable to dig into the

0:19:04.200 --> 0:19:08.200
<v Speaker 1>question even if we don't find an answer. And from

0:19:08.200 --> 0:19:10.359
<v Speaker 1>that perspective, I was really interested in the discussion you

0:19:10.400 --> 0:19:12.359
<v Speaker 1>had at the beginning of your book about, you know,

0:19:12.400 --> 0:19:15.880
<v Speaker 1>the sort of philosophy of what life might be. And

0:19:16.320 --> 0:19:19.000
<v Speaker 1>you were going through this discussion of like panpsychism, and

0:19:19.080 --> 0:19:22.320
<v Speaker 1>there's this one particular line that jumped out at me said, quote,

0:19:22.600 --> 0:19:25.920
<v Speaker 1>if life is not a property of matter, and material

0:19:26.000 --> 0:19:30.280
<v Speaker 1>things are what exists, then life does not exist. I

0:19:30.320 --> 0:19:32.960
<v Speaker 1>was wondering if you could expand on that thought. You know,

0:19:33.000 --> 0:19:35.800
<v Speaker 1>it doesn't it sort of ignore the possibility that life

0:19:35.840 --> 0:19:38.640
<v Speaker 1>could just be an emergent phenomenon, as you said, an arrangement,

0:19:38.680 --> 0:19:41.600
<v Speaker 1>a complexity of basic bits that are not alive.

0:19:42.560 --> 0:19:42.960
<v Speaker 8>Yeah.

0:19:43.000 --> 0:19:47.399
<v Speaker 6>So part of the reason that I structured things in

0:19:47.400 --> 0:19:49.560
<v Speaker 6>specific ways early on was to kind of set up

0:19:49.560 --> 0:19:51.320
<v Speaker 6>some things that come later in the book. And one

0:19:51.320 --> 0:19:55.280
<v Speaker 6>thing I've noticed being a physicist trying to build new

0:19:55.280 --> 0:19:59.440
<v Speaker 6>physics is that we take for granted things as being

0:19:59.640 --> 0:20:02.680
<v Speaker 6>apps asolutely true about the universe that were actually invented

0:20:02.680 --> 0:20:05.360
<v Speaker 6>by human minds trying to correlate the way that their

0:20:05.400 --> 0:20:08.720
<v Speaker 6>theories behave with things they could actually measure. The example

0:20:08.760 --> 0:20:10.520
<v Speaker 6>I like to give is to think about mass. It

0:20:10.560 --> 0:20:12.680
<v Speaker 6>seems so obvious to us that mass is a physical

0:20:12.720 --> 0:20:16.359
<v Speaker 6>property of objects, and it is a physical property we

0:20:16.400 --> 0:20:18.360
<v Speaker 6>talk about in our theories of physics because we can

0:20:18.400 --> 0:20:21.880
<v Speaker 6>measure it, and because Galileo rolling balls down in climbplanes

0:20:21.920 --> 0:20:24.280
<v Speaker 6>and other people of his generation realized that that was

0:20:24.320 --> 0:20:28.040
<v Speaker 6>the right variable to construct theories of motion. I think,

0:20:28.080 --> 0:20:30.320
<v Speaker 6>of course, you can talk about life as just being

0:20:30.320 --> 0:20:32.600
<v Speaker 6>an emergent property, but you're never going to get to

0:20:32.640 --> 0:20:37.119
<v Speaker 6>an objective understanding of it as a physical phenomena unless

0:20:37.160 --> 0:20:40.280
<v Speaker 6>you can tie it to a measurement. And therefore whatever

0:20:40.320 --> 0:20:42.120
<v Speaker 6>that thing is has to become what we would call

0:20:42.119 --> 0:20:44.720
<v Speaker 6>a material property in our theories of physics, because now

0:20:44.840 --> 0:20:48.240
<v Speaker 6>it's something we measure that becomes a variable in our theory.

0:20:48.280 --> 0:20:51.159
<v Speaker 6>Therefore it's physical. And I think this has been the

0:20:51.200 --> 0:20:54.399
<v Speaker 6>thing that's really hard about thinking about the nature of

0:20:54.440 --> 0:20:59.200
<v Speaker 6>life is it has forever been an epiphenomena and something

0:20:59.240 --> 0:21:01.600
<v Speaker 6>we couldn't regular rise as part of a law of nature.

0:21:02.040 --> 0:21:04.200
<v Speaker 8>Because we want to adopt this view that surely it's

0:21:04.359 --> 0:21:05.280
<v Speaker 8>just these.

0:21:05.119 --> 0:21:10.000
<v Speaker 6>Emergent informational patterns, but we can't measure them objectively. And

0:21:10.080 --> 0:21:13.760
<v Speaker 6>so my point saying that if you want to reduce

0:21:13.800 --> 0:21:16.480
<v Speaker 6>life that way, then life doesn't exist because you don't

0:21:16.560 --> 0:21:19.119
<v Speaker 6>have an objective measurement. You don't have a way of

0:21:19.200 --> 0:21:22.840
<v Speaker 6>grounding whatever you're talking about and testing it against reality

0:21:22.880 --> 0:21:25.240
<v Speaker 6>and saying this is the thing that emerges when life emerges.

0:21:25.600 --> 0:21:27.199
<v Speaker 1>If I could just stop you there, because I'm not

0:21:27.240 --> 0:21:30.600
<v Speaker 1>sure I'm following, Like, let's take a simpler example. You

0:21:30.600 --> 0:21:35.160
<v Speaker 1>know a thunderstorm. Thunderstorm is an emergent phenomenon bubbling up

0:21:35.200 --> 0:21:38.399
<v Speaker 1>from the you know, the properties of particles and molecules

0:21:38.400 --> 0:21:41.800
<v Speaker 1>and all this kind of stuff. Clearly thunderstorms exist, right,

0:21:41.920 --> 0:21:44.560
<v Speaker 1>we agree. We can make measurements of them, their intensity,

0:21:44.640 --> 0:21:46.280
<v Speaker 1>all sorts of stuff. We can ground them, we can

0:21:46.320 --> 0:21:50.280
<v Speaker 1>write even some you know, mathematical expressions that describe them

0:21:50.359 --> 0:21:54.040
<v Speaker 1>in some cases, How can we say thunderstorms exist and

0:21:54.080 --> 0:21:56.280
<v Speaker 1>we can make physical measurements of thunderstorms, but we can't

0:21:56.320 --> 0:21:57.960
<v Speaker 1>say the same thing about life.

0:21:58.280 --> 0:22:00.600
<v Speaker 8>Well, what would be the measurement that you're taking about life?

0:22:00.600 --> 0:22:00.760
<v Speaker 1>Though?

0:22:00.800 --> 0:22:03.400
<v Speaker 6>So the question with thunderstorms is it's a good example

0:22:03.480 --> 0:22:06.040
<v Speaker 6>because most of the measurements you're taking are things like

0:22:06.080 --> 0:22:09.520
<v Speaker 6>wind velocity, you know, the temperature. Like these are like

0:22:09.640 --> 0:22:12.040
<v Speaker 6>physical measurements you can go in and take, and then

0:22:12.040 --> 0:22:14.240
<v Speaker 6>when you put those in some model of a thunderstorm,

0:22:14.240 --> 0:22:16.680
<v Speaker 6>you can actually model the thunderstorm's behavior. And that same

0:22:16.760 --> 0:22:20.359
<v Speaker 6>physics works if you go on another planetary body and

0:22:20.400 --> 0:22:23.720
<v Speaker 6>account for differences in pressure and differences in the particular climate,

0:22:24.080 --> 0:22:26.000
<v Speaker 6>you know, in that gravitational field, and things like that.

0:22:27.280 --> 0:22:31.320
<v Speaker 6>The issue with life is, you know, most people want

0:22:31.359 --> 0:22:34.320
<v Speaker 6>to say that, like when you're talking about chemistry, and like,

0:22:34.440 --> 0:22:37.040
<v Speaker 6>life is an organizational property of chemistry. When we look

0:22:37.080 --> 0:22:38.879
<v Speaker 6>at its parts, we don't see the things that we

0:22:38.920 --> 0:22:42.040
<v Speaker 6>associate to life, and so therefore life is an emergent

0:22:42.040 --> 0:22:45.520
<v Speaker 6>property of those parts. It's some organizational feature. But the

0:22:45.560 --> 0:22:48.160
<v Speaker 6>problem is we don't have the rules to go from

0:22:48.560 --> 0:22:51.760
<v Speaker 6>the atoms and the parts to that organizational feature in

0:22:51.800 --> 0:22:53.800
<v Speaker 6>a universal way that would allow us to go on

0:22:53.840 --> 0:22:58.800
<v Speaker 6>another planet and measure that property. It's very subjective the

0:22:58.880 --> 0:23:01.720
<v Speaker 6>way that we talk about it, right, and so it's

0:23:01.760 --> 0:23:05.000
<v Speaker 6>okay if it's subjective and not a material property. It

0:23:05.040 --> 0:23:08.000
<v Speaker 6>might be that there is no law of physics that

0:23:08.080 --> 0:23:10.600
<v Speaker 6>allows us to understand what life is. And it might

0:23:10.640 --> 0:23:13.000
<v Speaker 6>be that life is not a universal category of nature.

0:23:13.440 --> 0:23:15.879
<v Speaker 6>It might just be some weird emergent pattern that emerged

0:23:15.920 --> 0:23:19.199
<v Speaker 6>on Earth and there's no universality to it. But the

0:23:19.440 --> 0:23:22.040
<v Speaker 6>argument that I'm interested in, and the one I think

0:23:22.080 --> 0:23:24.560
<v Speaker 6>that will actually help us find alien life that's out there,

0:23:24.600 --> 0:23:27.520
<v Speaker 6>because life is a universal thing if it is, is

0:23:27.560 --> 0:23:30.280
<v Speaker 6>that we need to figure out what are the objective properties.

0:23:30.359 --> 0:23:33.720
<v Speaker 6>And when you do that, in some sense, you're making

0:23:33.760 --> 0:23:36.520
<v Speaker 6>that property material in a way that it becomes measurable.

0:23:37.320 --> 0:23:39.480
<v Speaker 6>And so that's sort of the interplay. Like life has

0:23:39.600 --> 0:23:42.000
<v Speaker 6>not been a material property. We've had this sort of

0:23:42.040 --> 0:23:44.760
<v Speaker 6>vitalism and the idea of a soul. But the question

0:23:44.960 --> 0:23:48.880
<v Speaker 6>is is that actually something that we can quantify, put

0:23:48.920 --> 0:23:51.600
<v Speaker 6>into a theory, and also measure so that we can

0:23:51.640 --> 0:23:55.800
<v Speaker 6>actually say this is a real universal law like feature

0:23:55.840 --> 0:23:56.600
<v Speaker 6>of our universe.

0:23:56.960 --> 0:23:59.280
<v Speaker 5>But so then why go to life does not exist?

0:23:59.359 --> 0:24:03.000
<v Speaker 5>As opposed to we don't understand it well enough yet.

0:24:03.720 --> 0:24:07.679
<v Speaker 6>Because the logical conclusion of the way that much of

0:24:07.720 --> 0:24:09.840
<v Speaker 6>the discussion has been is that we should assume life

0:24:09.840 --> 0:24:12.359
<v Speaker 6>does not exist. So in some sense, what I'm trying

0:24:12.400 --> 0:24:15.040
<v Speaker 6>to do is actually provoke, you know, like, if we

0:24:15.160 --> 0:24:17.720
<v Speaker 6>run the way we talk about things to their logical conclusion,

0:24:17.720 --> 0:24:19.919
<v Speaker 6>what are we really saying And is this actually what

0:24:19.960 --> 0:24:20.920
<v Speaker 6>we intend to say?

0:24:21.359 --> 0:24:22.280
<v Speaker 8>Or do we want to say?

0:24:22.320 --> 0:24:25.000
<v Speaker 6>There's something missing from our descriptions of nature, and maybe

0:24:25.000 --> 0:24:27.159
<v Speaker 6>we need to rethink from first principles what it is

0:24:27.160 --> 0:24:30.159
<v Speaker 6>that we're doing. So I actually think life does exist.

0:24:30.200 --> 0:24:32.919
<v Speaker 6>I was always perplexed that a lot of my colleagues,

0:24:33.359 --> 0:24:35.280
<v Speaker 6>if you really listen to the words they were saying,

0:24:35.320 --> 0:24:37.520
<v Speaker 6>were implying that it does not exist, and some of

0:24:37.520 --> 0:24:39.760
<v Speaker 6>them even saying it outright, that like, we should just

0:24:39.800 --> 0:24:41.880
<v Speaker 6>not think about the problem of defining life at all.

0:24:42.200 --> 0:24:45.000
<v Speaker 6>Life is not a category of nature. It's all reducible

0:24:45.000 --> 0:24:48.520
<v Speaker 6>to chemistry and physics. And I think that there's something

0:24:48.600 --> 0:24:52.440
<v Speaker 6>deeply missing in what life is and why we keep

0:24:52.440 --> 0:24:54.399
<v Speaker 6>asking this question? So why is it a question we

0:24:54.440 --> 0:24:57.520
<v Speaker 6>ponder in bars at night. It's probably because we feel

0:24:57.560 --> 0:25:00.800
<v Speaker 6>intrinsically we're missing something about, you know, the descriptions of

0:25:00.840 --> 0:25:04.040
<v Speaker 6>the world around us that's pretty fundamental. So that was

0:25:04.040 --> 0:25:06.840
<v Speaker 6>always my perspective. Now that might not be right, but

0:25:06.920 --> 0:25:09.040
<v Speaker 6>I think the way to find out if that's.

0:25:08.960 --> 0:25:11.040
<v Speaker 8>Right is try to go through the process.

0:25:10.960 --> 0:25:13.000
<v Speaker 6>Of building a theory you can test against something you

0:25:13.040 --> 0:25:16.840
<v Speaker 6>can measure, and trying to see if empirically you're actually

0:25:17.000 --> 0:25:19.480
<v Speaker 6>getting the right results, and if you're building a theory

0:25:19.480 --> 0:25:22.800
<v Speaker 6>that is all explanatory of the data that we see

0:25:22.800 --> 0:25:24.080
<v Speaker 6>in the observations we can make.

0:25:24.800 --> 0:25:27.280
<v Speaker 1>Right, So you're not saying I don't exist, or you

0:25:27.400 --> 0:25:30.280
<v Speaker 1>don't exist, or my cat doesn't exist. You're saying that

0:25:30.400 --> 0:25:33.639
<v Speaker 1>we don't have a clear and crisp definition of life

0:25:33.960 --> 0:25:35.840
<v Speaker 1>that lets us do things that we typically do in

0:25:35.880 --> 0:25:38.480
<v Speaker 1>physical theories, like we do with thunderstorms and we do

0:25:38.560 --> 0:25:41.080
<v Speaker 1>with cats, because we can make measurements of them. We

0:25:41.119 --> 0:25:44.359
<v Speaker 1>can other than just like vaguely talking about sort of

0:25:44.880 --> 0:25:46.840
<v Speaker 1>fuzzy conceptual categories.

0:25:47.080 --> 0:25:49.159
<v Speaker 6>Yeah, I mean, in part, you know, the book is

0:25:49.160 --> 0:25:51.800
<v Speaker 6>an exercise of trying to turn a philosophical question into

0:25:51.840 --> 0:25:52.680
<v Speaker 6>a scientific one.

0:25:52.760 --> 0:25:53.040
<v Speaker 1>Yeah.

0:25:53.160 --> 0:25:56.119
<v Speaker 6>Right, So this has traditionally been a philosophical debate because

0:25:56.119 --> 0:25:58.240
<v Speaker 6>we don't have the things that we can pin the

0:25:58.400 --> 0:26:00.919
<v Speaker 6>debate into measurements to actually go test what it is

0:26:00.920 --> 0:26:03.800
<v Speaker 6>that we're talking about. And I think that's really the

0:26:03.840 --> 0:26:07.520
<v Speaker 6>critical transition that you know, most interesting science starts as

0:26:07.520 --> 0:26:12.000
<v Speaker 6>philosophical questions. And the period where the philosophy transitions to

0:26:12.040 --> 0:26:14.960
<v Speaker 6>science is always deeply interesting because we're asking exactly these

0:26:15.000 --> 0:26:17.640
<v Speaker 6>like really basic questions. It forces you to even ask

0:26:17.680 --> 0:26:19.760
<v Speaker 6>what science is, what is a measurement?

0:26:19.880 --> 0:26:21.959
<v Speaker 8>What is a theory? How do you build a new theory?

0:26:22.080 --> 0:26:23.840
<v Speaker 6>Like what are we even talking about ever when we

0:26:23.880 --> 0:26:26.560
<v Speaker 6>talk about things in science? So this is why it's exciting,

0:26:26.640 --> 0:26:30.120
<v Speaker 6>But it is really challenging because you're confronting things that

0:26:30.440 --> 0:26:33.520
<v Speaker 6>you know, we haven't known how to think about, and

0:26:33.560 --> 0:26:37.239
<v Speaker 6>you're saying, let's pin ourselves down and be precise and

0:26:37.280 --> 0:26:40.400
<v Speaker 6>think about it and ask, how would we actually quantify

0:26:40.440 --> 0:26:43.040
<v Speaker 6>and measure this thing? And how will we build a

0:26:43.080 --> 0:26:45.600
<v Speaker 6>theory that describes this thing? And if you look at

0:26:45.600 --> 0:26:47.720
<v Speaker 6>the history of science, what excites me about it and

0:26:47.840 --> 0:26:49.800
<v Speaker 6>why I think any of the ideas that we're doing

0:26:49.920 --> 0:26:52.320
<v Speaker 6>might be on the right track is you know, every

0:26:52.320 --> 0:26:54.640
<v Speaker 6>time that that process has happened in the history of physics,

0:26:54.640 --> 0:26:56.800
<v Speaker 6>we come out the other side with a radically different

0:26:56.800 --> 0:27:00.119
<v Speaker 6>conception of what's going on than we had before. My

0:27:00.119 --> 0:27:03.160
<v Speaker 6>favorite example is like to think about you know, saying

0:27:03.280 --> 0:27:06.080
<v Speaker 6>terrestrial and celestial motion are the same thing. It's like,

0:27:06.119 --> 0:27:08.080
<v Speaker 6>you know, humans had been around for hundreds of thousands

0:27:08.080 --> 0:27:09.840
<v Speaker 6>of years seeing the stars and the night sky and

0:27:09.880 --> 0:27:13.159
<v Speaker 6>planets moving across the sky, and we never thought like

0:27:13.240 --> 0:27:14.080
<v Speaker 6>that would be you know.

0:27:14.080 --> 0:27:15.520
<v Speaker 8>Like the theory of gravitation.

0:27:15.560 --> 0:27:19.720
<v Speaker 6>It took you know, centuries of measurement and coming to

0:27:20.040 --> 0:27:22.720
<v Speaker 6>you know, track the regularities of heavenly motions and be

0:27:22.800 --> 0:27:25.600
<v Speaker 6>able to get clocks that were precise enough timing to

0:27:26.119 --> 0:27:30.520
<v Speaker 6>actually build into an understanding of a theory of motion

0:27:30.680 --> 0:27:32.680
<v Speaker 6>and gravitation that allowed us to look up at the

0:27:32.720 --> 0:27:35.480
<v Speaker 6>sky and be like, oh, those things are actually moving

0:27:35.520 --> 0:27:37.600
<v Speaker 6>in the same way that things on Earth move. I mean,

0:27:37.680 --> 0:27:40.560
<v Speaker 6>these are radical conceptual leaps that our species has taken,

0:27:40.600 --> 0:27:42.320
<v Speaker 6>and I think to think that we're done doing that

0:27:42.440 --> 0:27:45.040
<v Speaker 6>is really premature. So I get excited about life and

0:27:45.040 --> 0:27:47.240
<v Speaker 6>when people say, well, isn't it just a pattern of motions,

0:27:47.240 --> 0:27:48.600
<v Speaker 6>and I'm like, well, of course it is. But we've

0:27:48.640 --> 0:27:51.800
<v Speaker 6>explained lots of those before in really deep and fundamental ways,

0:27:51.840 --> 0:27:52.919
<v Speaker 6>so maybe we should try again.

0:27:53.200 --> 0:27:56.479
<v Speaker 1>All right, I have lots more questions about this squishy topic,

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0:31:41.040 --> 0:31:43.560
<v Speaker 1>back and we're trying to sort through the slimy questions

0:31:43.560 --> 0:31:46.640
<v Speaker 1>of the physics of life with Professor Sarah Amari Walker,

0:31:47.040 --> 0:31:49.200
<v Speaker 1>author of the book Life As No One Knows It

0:31:50.160 --> 0:31:53.680
<v Speaker 1>Well in terms of taking like a radical conceptual philosophical leaps,

0:31:53.800 --> 0:31:56.360
<v Speaker 1>I was very excited to see you open the door

0:31:56.880 --> 0:32:00.560
<v Speaker 1>to getting rid of reductionism. I mean especially as of physicists,

0:32:00.880 --> 0:32:04.000
<v Speaker 1>you know, and as you described earlier, physics is so

0:32:04.400 --> 0:32:07.200
<v Speaker 1>ingrained in the idea of like, let's find the microscopic

0:32:07.240 --> 0:32:09.800
<v Speaker 1>explanation for everything. Start with what we hope is the

0:32:09.800 --> 0:32:13.000
<v Speaker 1>fundamental and everything will bubble up from there somehow dot

0:32:13.040 --> 0:32:16.200
<v Speaker 1>dot dot right. Leave that as an exercise for the engineers.

0:32:16.640 --> 0:32:20.440
<v Speaker 1>But in your book you actually consider the other approach,

0:32:20.520 --> 0:32:23.640
<v Speaker 1>the idea that, like, maybe not everything is determined from

0:32:23.640 --> 0:32:27.640
<v Speaker 1>the smallest bits. Maybe what we see as like emergent

0:32:27.640 --> 0:32:32.480
<v Speaker 1>phenomena different scales actually have their own different fundamental description that, like,

0:32:32.760 --> 0:32:35.880
<v Speaker 1>you know, the universe isn't controlled by the tiniest Can

0:32:35.920 --> 0:32:37.200
<v Speaker 1>you talk a little bit about that. I think that's

0:32:37.200 --> 0:32:40.000
<v Speaker 1>probably a very unfamiliar concept for our listeners who are

0:32:40.080 --> 0:32:42.840
<v Speaker 1>used to, especially on this podcast, hearing us talk about

0:32:42.920 --> 0:32:45.400
<v Speaker 1>how tiny particles weave together to make the universe.

0:32:46.400 --> 0:32:49.240
<v Speaker 6>Yeah, and I also love that view of reality. I

0:32:49.240 --> 0:32:51.640
<v Speaker 6>think it's like incredibly romantic, and I was trained in

0:32:51.640 --> 0:32:55.560
<v Speaker 6>that tradition. But thinking about life and really trying to

0:32:55.960 --> 0:32:58.560
<v Speaker 6>ask the question whether there were universal laws of life

0:32:58.600 --> 0:33:01.240
<v Speaker 6>like that speaks to me that looking for something fundamental,

0:33:01.240 --> 0:33:04.200
<v Speaker 6>because it has to be universal and broadly explanatory of

0:33:04.200 --> 0:33:08.200
<v Speaker 6>any life in the universe, you start to ask questions

0:33:08.200 --> 0:33:11.040
<v Speaker 6>about the nature of what's fundamental. And as I already

0:33:11.040 --> 0:33:12.720
<v Speaker 6>alluded to before, a lot of the ways that we

0:33:12.760 --> 0:33:16.560
<v Speaker 6>think about what's fundamental are what things we can go

0:33:16.600 --> 0:33:18.880
<v Speaker 6>in the lab and test that build the structure of

0:33:18.880 --> 0:33:21.960
<v Speaker 6>our theories, and so some of the most precise theories

0:33:21.960 --> 0:33:26.600
<v Speaker 6>we have are these ones about microscopical physical motions, but

0:33:26.640 --> 0:33:29.360
<v Speaker 6>it doesn't mean that they explain everything. And one of

0:33:29.360 --> 0:33:31.680
<v Speaker 6>the points that I make in the book, which is

0:33:31.720 --> 0:33:35.280
<v Speaker 6>related to this sort of evolutionary progress of knowledge that

0:33:35.320 --> 0:33:37.800
<v Speaker 6>we've been talking about about, like disciplines changing over time,

0:33:37.880 --> 0:33:40.479
<v Speaker 6>is the notion of what's fundamental has actually changed with

0:33:40.560 --> 0:33:43.840
<v Speaker 6>our theories and with our measuring devices, and so I think,

0:33:44.400 --> 0:33:46.440
<v Speaker 6>you know, like the canonical example I like to give

0:33:46.520 --> 0:33:48.840
<v Speaker 6>is to think about atoms, which we thought for a

0:33:48.880 --> 0:33:51.200
<v Speaker 6>long time or indivisible units of matter until we build

0:33:51.200 --> 0:33:53.840
<v Speaker 6>better technology and we realized they had parts. And so

0:33:53.880 --> 0:33:56.400
<v Speaker 6>I'm not sure that there's really a bottom to that process.

0:33:57.080 --> 0:33:59.680
<v Speaker 6>If string theory is right, obviously all the elementary particles

0:33:59.680 --> 0:34:01.560
<v Speaker 6>and things we think are you know, the full description

0:34:01.640 --> 0:34:05.160
<v Speaker 6>and reality are not right. But we can't validate theories

0:34:05.160 --> 0:34:08.720
<v Speaker 6>that go smaller because we don't have the technology yet.

0:34:09.520 --> 0:34:12.920
<v Speaker 6>So you know, that becomes a horizon of our current

0:34:13.080 --> 0:34:16.920
<v Speaker 6>understanding of reality, not something that's intrinsic to reality itself.

0:34:18.200 --> 0:34:20.600
<v Speaker 6>And if you flip that around and you look at

0:34:21.080 --> 0:34:23.280
<v Speaker 6>what you're trying to do building a theory of life,

0:34:23.760 --> 0:34:25.960
<v Speaker 6>life is built out of these what we think are

0:34:25.960 --> 0:34:29.200
<v Speaker 6>fundamental building blocks. But the kinds of things that we

0:34:29.200 --> 0:34:32.200
<v Speaker 6>want to understand about life are much more about how

0:34:32.280 --> 0:34:36.600
<v Speaker 6>the universe builds complexity out of small parts. And it

0:34:36.680 --> 0:34:39.479
<v Speaker 6>is the case that if we can think about things

0:34:39.520 --> 0:34:42.759
<v Speaker 6>that we can measure there and build theories there, there's

0:34:42.760 --> 0:34:45.160
<v Speaker 6>no reason to think they're not just as fundamental as

0:34:45.160 --> 0:34:46.640
<v Speaker 6>these other descriptions of nature.

0:34:47.000 --> 0:34:47.920
<v Speaker 8>So that's sort of like the.

0:34:47.880 --> 0:34:51.919
<v Speaker 6>Baseline philosophy I'm operating from. But the sort of core

0:34:51.920 --> 0:34:53.720
<v Speaker 6>of your question, I think is more about the emergence

0:34:53.760 --> 0:34:57.880
<v Speaker 6>reductionism debate, not the philosophy of measurement and what's fundamental.

0:34:57.960 --> 0:35:00.440
<v Speaker 6>But I think like those things are coupled, so I

0:35:00.480 --> 0:35:04.960
<v Speaker 6>wanted to preface it. But the emergence reductionism, you know,

0:35:05.520 --> 0:35:07.400
<v Speaker 6>Phil Anderson had this great essay which a lot of

0:35:07.440 --> 0:35:09.520
<v Speaker 6>people have read and love about this idea of more

0:35:09.640 --> 0:35:12.080
<v Speaker 6>is different. You know, even if you had that fundamental description,

0:35:12.160 --> 0:35:14.239
<v Speaker 6>it doesn't mean that as you go to these other

0:35:14.360 --> 0:35:18.719
<v Speaker 6>layers like biology and mind and technology, you're going to

0:35:18.719 --> 0:35:20.879
<v Speaker 6>actually be able to recover all the features of them.

0:35:21.440 --> 0:35:25.080
<v Speaker 6>And so this has been deeply perplexing. And what I

0:35:25.120 --> 0:35:27.840
<v Speaker 6>suggest in the book is one of the reasons you

0:35:27.880 --> 0:35:31.200
<v Speaker 6>can't go between scales, is there actually are separate laws

0:35:31.239 --> 0:35:33.960
<v Speaker 6>that describe the idea of a hierarchy in the first place,

0:35:33.960 --> 0:35:36.879
<v Speaker 6>that the universe is actually constructing complexity, and that time

0:35:36.920 --> 0:35:40.279
<v Speaker 6>needs to be a component of that process. So if

0:35:40.280 --> 0:35:45.279
<v Speaker 6>you remove you know, evolutionary time, you know, you can

0:35:45.320 --> 0:35:48.880
<v Speaker 6>talk about me being an emergent property of my atoms.

0:35:48.920 --> 0:35:51.120
<v Speaker 6>But I've missed almost all of the physics that's in

0:35:51.200 --> 0:35:53.359
<v Speaker 6>my body. I am like the product of four billion

0:35:53.400 --> 0:35:55.640
<v Speaker 6>years of evolution, and so if I want to talk

0:35:55.640 --> 0:35:58.319
<v Speaker 6>about me as a fundamental structure, I need to talk

0:35:58.320 --> 0:36:02.839
<v Speaker 6>about that feature, not the atoms in my body. And

0:36:02.920 --> 0:36:05.239
<v Speaker 6>so it's really trying to invert the nature of like

0:36:05.320 --> 0:36:08.160
<v Speaker 6>what is the thing that actually explains this. You can

0:36:08.200 --> 0:36:11.720
<v Speaker 6>say I'm an emergent property, but it doesn't explain from.

0:36:11.600 --> 0:36:14.080
<v Speaker 8>Those laws, those lower level laws, how I got here

0:36:14.120 --> 0:36:14.880
<v Speaker 8>and why I exist.

0:36:15.200 --> 0:36:17.520
<v Speaker 1>But does that mean that there is no explanation that

0:36:17.560 --> 0:36:19.719
<v Speaker 1>you have to have fundamental laws at every scale or

0:36:19.719 --> 0:36:22.960
<v Speaker 1>does it just mean those explanations escape us currently or

0:36:23.000 --> 0:36:25.960
<v Speaker 1>our current ability to do those calculations. And in some

0:36:26.239 --> 0:36:29.520
<v Speaker 1>future where we have an amazing supercomputer, we can model

0:36:29.560 --> 0:36:30.840
<v Speaker 1>everything from the tiniest bits.

0:36:31.360 --> 0:36:35.400
<v Speaker 6>I think it's both of the last things you said.

0:36:36.120 --> 0:36:41.160
<v Speaker 6>So I think there you cannot produce things like us

0:36:41.320 --> 0:36:43.759
<v Speaker 6>from the current structure the laws of physics. I don't

0:36:43.800 --> 0:36:46.080
<v Speaker 6>even think if you had a super massive supercomputer you

0:36:46.080 --> 0:36:48.799
<v Speaker 6>could do it. And a simple reason to cite that

0:36:49.000 --> 0:36:51.719
<v Speaker 6>is it would require more computation than is available in

0:36:51.760 --> 0:36:54.960
<v Speaker 6>all of the resources of the entire universe. And yet

0:36:54.960 --> 0:36:58.040
<v Speaker 6>the universe builds things like us. And so I think

0:36:58.080 --> 0:37:00.760
<v Speaker 6>that right there suggests that something fun mental is missing,

0:37:01.600 --> 0:37:03.960
<v Speaker 6>because you could say, in principle, you could simulate it,

0:37:04.000 --> 0:37:07.520
<v Speaker 6>and you could generate our conversation that we're having right now,

0:37:07.760 --> 0:37:10.600
<v Speaker 6>but actually, in principle is not in principle because it's

0:37:10.640 --> 0:37:13.560
<v Speaker 6>not even physically possible. So those things, to me suggest

0:37:13.560 --> 0:37:16.840
<v Speaker 6>that there's a huge gap in understanding. But I also

0:37:17.000 --> 0:37:23.760
<v Speaker 6>think fundamentally that the physics of what describes living things

0:37:24.280 --> 0:37:27.360
<v Speaker 6>is not encapsulated in the physics that we have of

0:37:27.960 --> 0:37:31.959
<v Speaker 6>gravitational fields or elementary particles or any sort of state

0:37:32.000 --> 0:37:34.160
<v Speaker 6>of the art in modern physics departments. I think it's

0:37:34.280 --> 0:37:37.080
<v Speaker 6>just not in those equations. And the reason I think

0:37:37.080 --> 0:37:39.040
<v Speaker 6>it's not in those equations is because life is very

0:37:39.080 --> 0:37:43.040
<v Speaker 6>much about the causation and time that's built into physical

0:37:43.080 --> 0:37:46.040
<v Speaker 6>objects that are complex. And if you think about what

0:37:46.080 --> 0:37:49.799
<v Speaker 6>the laws of physics revealed, they are often designed for

0:37:49.880 --> 0:37:53.440
<v Speaker 6>specific problems, and they tell you what's universal about a

0:37:53.560 --> 0:37:57.440
<v Speaker 6>set of questions like motion, for example, like all moving

0:37:57.480 --> 0:38:02.319
<v Speaker 6>objects you know, can be described by mass acceleration and

0:38:02.560 --> 0:38:04.239
<v Speaker 6>you don't care about the color of them or how

0:38:04.280 --> 0:38:06.560
<v Speaker 6>those objects feel or other things. But that doesn't mean

0:38:06.600 --> 0:38:11.200
<v Speaker 6>that those laws explain everything about every object. And so

0:38:12.040 --> 0:38:14.399
<v Speaker 6>you know, the question is how many kinds of laws

0:38:14.400 --> 0:38:17.440
<v Speaker 6>of physics do we need? What's the sort of universal

0:38:17.440 --> 0:38:19.680
<v Speaker 6>set of things that they cover? And I think life

0:38:19.800 --> 0:38:23.480
<v Speaker 6>is presenting some real challenges for the sort of current

0:38:23.520 --> 0:38:26.160
<v Speaker 6>paradigm that we have in really fundamental ways.

0:38:26.800 --> 0:38:30.279
<v Speaker 5>Again, as the biologist in the conversation, so I feel

0:38:30.280 --> 0:38:33.280
<v Speaker 5>like what I'm hearing is that we don't really understand

0:38:33.280 --> 0:38:36.760
<v Speaker 5>the physics stuff, but we know that life is something

0:38:36.840 --> 0:38:39.440
<v Speaker 5>that comes about through the process of evolution. So I

0:38:39.440 --> 0:38:42.600
<v Speaker 5>feel like we're back in an evolutionary biology lab. Yes,

0:38:43.120 --> 0:38:46.719
<v Speaker 5>how how does a physicist study it differently? Like is

0:38:46.719 --> 0:38:51.160
<v Speaker 5>the question what process results in something that natural selection

0:38:51.280 --> 0:38:54.600
<v Speaker 5>can then act on? Like when we you know, put

0:38:54.600 --> 0:38:57.319
<v Speaker 5>the pedal to the metal or whatever, like what do

0:38:57.440 --> 0:39:00.120
<v Speaker 5>we do in a lab or on a board for

0:39:00.320 --> 0:39:01.520
<v Speaker 5>with equations that's different.

0:39:01.800 --> 0:39:02.520
<v Speaker 8>So this is a.

0:39:02.480 --> 0:39:06.719
<v Speaker 6>Great question because ultimately, like Daniel's question, can you know

0:39:07.000 --> 0:39:09.960
<v Speaker 6>what will ultimately resolve it is? Does providing a new

0:39:10.000 --> 0:39:13.319
<v Speaker 6>explanation provide any new experimental tests and things we couldn't do.

0:39:13.360 --> 0:39:15.680
<v Speaker 8>Otherwise because it doesn't.

0:39:15.719 --> 0:39:17.560
<v Speaker 6>I could tell you, you know, I could sit here

0:39:17.640 --> 0:39:21.120
<v Speaker 6>all day arguing that there's other laws of physics in life,

0:39:21.120 --> 0:39:23.040
<v Speaker 6>and you know you could nod your head, Okay, Sarah,

0:39:23.080 --> 0:39:24.839
<v Speaker 6>but show me the proof, right, And I've been doing

0:39:24.840 --> 0:39:26.759
<v Speaker 6>this most of my career because you know, I have

0:39:26.840 --> 0:39:28.640
<v Speaker 6>like some conviction it's there, but we have to do

0:39:28.680 --> 0:39:29.320
<v Speaker 6>the hard work.

0:39:29.120 --> 0:39:31.400
<v Speaker 8>As scientists and show that it's useful for something.

0:39:32.440 --> 0:39:36.239
<v Speaker 6>And I think, I think to your question, the challenge is,

0:39:36.840 --> 0:39:40.920
<v Speaker 6>you know, for the most part, we think about evolution

0:39:41.080 --> 0:39:45.040
<v Speaker 6>and selection as being things that life does. But that

0:39:45.080 --> 0:39:47.760
<v Speaker 6>doesn't allow us to explain the origin of life because

0:39:48.320 --> 0:39:53.040
<v Speaker 6>it has to be some spontaneous fluctuation with no mechanism, right,

0:39:53.160 --> 0:39:55.799
<v Speaker 6>and so or it's just a rare fluke, right, And

0:39:55.840 --> 0:39:57.839
<v Speaker 6>then if it's a rare fluke, then you know, none

0:39:57.880 --> 0:40:00.160
<v Speaker 6>of this discussion is necessary because it's just some thing

0:40:00.239 --> 0:40:02.839
<v Speaker 6>that happened and there's no explanation for it.

0:40:02.719 --> 0:40:04.560
<v Speaker 8>It was just, you know, a rare fluch event.

0:40:04.600 --> 0:40:06.360
<v Speaker 6>And I think this is one of the challenges because

0:40:06.360 --> 0:40:08.960
<v Speaker 6>that allows you know, intelligent design and other things to

0:40:09.000 --> 0:40:12.239
<v Speaker 6>be equivalent explanations to the scientific one, because we don't

0:40:12.239 --> 0:40:15.640
<v Speaker 6>have an explanation. So if you really want to explain it,

0:40:15.680 --> 0:40:17.440
<v Speaker 6>you kind of have to assume. The original life is

0:40:17.440 --> 0:40:20.799
<v Speaker 6>itself a process of selection and evolution. So it's the

0:40:20.800 --> 0:40:23.839
<v Speaker 6>product of those kind of mechanisms, which means you need

0:40:23.880 --> 0:40:27.680
<v Speaker 6>an understanding of evolution that doesn't require.

0:40:27.360 --> 0:40:30.919
<v Speaker 8>A cellular architecture. And this is the main challenge, right so.

0:40:30.960 --> 0:40:36.680
<v Speaker 6>Before replication, before natural selection as we understand it now

0:40:36.840 --> 0:40:39.760
<v Speaker 6>in genes or the way it operates in biological populations,

0:40:40.040 --> 0:40:43.200
<v Speaker 6>out of chemistry, how does an evolutionary system get constructed?

0:40:44.000 --> 0:40:47.359
<v Speaker 6>And so this is really the question that we're trying

0:40:47.360 --> 0:40:49.400
<v Speaker 6>to ask is how do you get complexity when there

0:40:49.480 --> 0:40:54.000
<v Speaker 6>is none? And so that's where we need a new paradigm,

0:40:54.080 --> 0:40:58.560
<v Speaker 6>because we need a mechanism of selection that operates starting

0:40:58.600 --> 0:41:01.560
<v Speaker 6>from simple molecules building into the complexity of life. And

0:41:01.560 --> 0:41:03.880
<v Speaker 6>that's really the theory that we're working on. This assembly

0:41:03.920 --> 0:41:07.440
<v Speaker 6>theory is really an approach to talking about selection in

0:41:07.520 --> 0:41:10.800
<v Speaker 6>the absence of like when selection emerges, how do selection

0:41:11.360 --> 0:41:15.239
<v Speaker 6>actually start? And how to selection build evolutionary systems that

0:41:15.239 --> 0:41:18.320
<v Speaker 6>we would recognize as evolving things. And so it's suggesting

0:41:18.360 --> 0:41:21.839
<v Speaker 6>a much more universal structure to the evolutionary process then

0:41:22.040 --> 0:41:25.040
<v Speaker 6>the particular things that were selected and evolved on Earth.

0:41:25.640 --> 0:41:28.760
<v Speaker 6>To understanding what are the general principles of the kinds

0:41:28.800 --> 0:41:32.040
<v Speaker 6>of systems that chemistry could generate that could lead to

0:41:32.040 --> 0:41:35.799
<v Speaker 6>this process of evolution that we recognize. That's the question

0:41:35.840 --> 0:41:39.240
<v Speaker 6>we're trying to answer, and I think that one really

0:41:39.280 --> 0:41:42.719
<v Speaker 6>does demand new physical principles because you're asking out of

0:41:43.239 --> 0:41:46.520
<v Speaker 6>I mean, people really don't understand how big chemical space is.

0:41:46.680 --> 0:41:49.680
<v Speaker 6>It is like astronomically large. We also do a lot

0:41:49.719 --> 0:41:51.800
<v Speaker 6>of stuff with drug design with the same theories that

0:41:51.840 --> 0:41:53.279
<v Speaker 6>we're trying to sell the original life, which is kind

0:41:53.280 --> 0:41:56.760
<v Speaker 6>of crazy. So I deal with like you know, pharmaceutical

0:41:56.960 --> 0:41:59.280
<v Speaker 6>drugs and this kind of stuff. But like when keminformatics

0:41:59.280 --> 0:42:00.960
<v Speaker 6>go in and they want to estimate the size of

0:42:00.960 --> 0:42:03.120
<v Speaker 6>the chemical space they have to search to look for

0:42:03.160 --> 0:42:06.560
<v Speaker 6>new drug like properties. It is insane it's not small,

0:42:06.640 --> 0:42:10.080
<v Speaker 6>it's insanely large, you know. I think a really good

0:42:10.280 --> 0:42:12.480
<v Speaker 6>example is like taxol is a molecule I use a

0:42:12.520 --> 0:42:14.239
<v Speaker 6>lot of times when I give lectures that I picked

0:42:14.280 --> 0:42:16.600
<v Speaker 6>up from my colleged Lee Kronin. That molecule has an

0:42:16.640 --> 0:42:19.640
<v Speaker 6>molecrooid of about eight hundred and fifty three. You know,

0:42:19.680 --> 0:42:22.680
<v Speaker 6>I think it has like forty seven carbon atoms or

0:42:22.760 --> 0:42:25.799
<v Speaker 6>fifty three or something oxygen. Anyway, Like, if you wanted

0:42:25.840 --> 0:42:28.880
<v Speaker 6>to do all the molecules with that chemical formula alone,

0:42:28.880 --> 0:42:31.319
<v Speaker 6>it would fill a volume of one point five universes.

0:42:32.040 --> 0:42:36.279
<v Speaker 6>So if you think about a planet generating chemical chemistry

0:42:37.080 --> 0:42:41.480
<v Speaker 6>in an unconstrained way, no selection, the space of molecules

0:42:41.480 --> 0:42:44.360
<v Speaker 6>that could be you know, just randomly synthesized is so

0:42:44.440 --> 0:42:48.400
<v Speaker 6>astronomically large you would never expect anything complex to recur twice.

0:42:49.440 --> 0:42:51.359
<v Speaker 6>And so this is kind of a key argument of

0:42:51.480 --> 0:42:53.680
<v Speaker 6>the way that we constructed the theory. When you start

0:42:53.719 --> 0:42:56.880
<v Speaker 6>to see things that involve a lot of constraints in

0:42:56.920 --> 0:42:59.759
<v Speaker 6>the space of possibilities to get these really complex, really

0:43:00.040 --> 0:43:05.200
<v Speaker 6>probable objects with a high abundance that they're happening a lot,

0:43:05.960 --> 0:43:09.200
<v Speaker 6>that's evidence of selection happening and that selection is actually

0:43:09.239 --> 0:43:11.400
<v Speaker 6>the physics generating those objects. But it's got to be

0:43:11.440 --> 0:43:14.120
<v Speaker 6>much deeper than what we just see and involved architectures

0:43:14.280 --> 0:43:15.959
<v Speaker 6>that we have, like with the cell, because that comes

0:43:15.960 --> 0:43:17.560
<v Speaker 6>fairly late in new original Aye process.

0:43:17.840 --> 0:43:20.319
<v Speaker 1>So I understand that the space is very large, right,

0:43:20.320 --> 0:43:23.600
<v Speaker 1>Obviously there's lots of different combinations. Chemistry is complicated. But

0:43:23.680 --> 0:43:27.520
<v Speaker 1>how do we know what's improbable or what's unusual because

0:43:27.560 --> 0:43:30.080
<v Speaker 1>the space is so large and we haven't explored it, right,

0:43:30.120 --> 0:43:32.880
<v Speaker 1>And you say, for example, like the existence of rockets

0:43:32.880 --> 0:43:35.359
<v Speaker 1>in the universe is a sign of like conscious thought

0:43:35.400 --> 0:43:37.479
<v Speaker 1>or whatever. But you know, how do we know them

0:43:37.719 --> 0:43:39.160
<v Speaker 1>that that's the case? How do we know that other

0:43:39.360 --> 0:43:42.480
<v Speaker 1>arrangements that our particular planet didn't explore don't lead to

0:43:42.600 --> 0:43:46.440
<v Speaker 1>greater complexity or more interesting things existing in the universe.

0:43:46.880 --> 0:43:49.200
<v Speaker 6>So your question is a good one, and I think

0:43:49.239 --> 0:43:52.000
<v Speaker 6>a lot of us have sort of embedded in the

0:43:52.040 --> 0:43:53.960
<v Speaker 6>way that we think about the world. And this actually

0:43:53.960 --> 0:43:55.839
<v Speaker 6>comes from the way that we think about physics. It's

0:43:55.840 --> 0:43:59.800
<v Speaker 6>sort of a heritage legacy actually from the eighteen hundreds

0:43:59.840 --> 0:44:02.440
<v Speaker 6>and the development of statistical mechanics and the idea of

0:44:02.480 --> 0:44:05.959
<v Speaker 6>spontaneous fluctuation. We have an idea in our minds that

0:44:06.480 --> 0:44:12.000
<v Speaker 6>anything of arbitrarily complexity can spontaneously fluctuate into existence. And

0:44:12.040 --> 0:44:14.240
<v Speaker 6>this is the whole impetus of the Boltzmann brain argument,

0:44:14.280 --> 0:44:16.840
<v Speaker 6>which actually was proposed by Eddington originally as kind of

0:44:16.840 --> 0:44:20.200
<v Speaker 6>a mocking of Boltzman's ideas, but then became something that

0:44:20.320 --> 0:44:22.560
<v Speaker 6>physicists took very seriously and tried to put in our

0:44:22.600 --> 0:44:27.479
<v Speaker 6>cosmological models. And so the challenge there is, of course,

0:44:27.520 --> 0:44:30.399
<v Speaker 6>we can say, you know, a planet can make an

0:44:30.520 --> 0:44:34.160
<v Speaker 6>arbitrarily complex molecule, right, I can make that statement, and

0:44:34.239 --> 0:44:37.600
<v Speaker 6>it seems intuitively logical. But if I said, you know,

0:44:37.680 --> 0:44:40.360
<v Speaker 6>Mars is going to generate a cell phone tomorrow, you

0:44:40.400 --> 0:44:42.520
<v Speaker 6>would kind of laugh at me, right, Like that's.

0:44:42.400 --> 0:44:43.280
<v Speaker 8>A silly statement.

0:44:43.920 --> 0:44:46.000
<v Speaker 6>Is there really a chance that we could just find

0:44:46.000 --> 0:44:48.120
<v Speaker 6>the planet Mars generating a cell phone, and like, not

0:44:48.200 --> 0:44:52.600
<v Speaker 6>a cell phone, but just something equivalent amount of organization

0:44:53.200 --> 0:44:57.399
<v Speaker 6>and evolutionary processes, Like a cell phone takes four billion

0:44:57.440 --> 0:44:59.200
<v Speaker 6>years to make on a planet. It takes a lot

0:44:59.200 --> 0:45:01.799
<v Speaker 6>of selection to get to that very specific object. It's

0:45:01.880 --> 0:45:04.600
<v Speaker 6>really designed for our biology. The technology is built on

0:45:04.600 --> 0:45:10.080
<v Speaker 6>our planetary resources, Like everything about that object is a

0:45:10.120 --> 0:45:12.640
<v Speaker 6>direct consequence of the fact that we've had four billion

0:45:12.680 --> 0:45:15.360
<v Speaker 6>years of evolution along a specific trajectory on our planet,

0:45:16.040 --> 0:45:18.319
<v Speaker 6>and so to assume an object like that can just

0:45:18.760 --> 0:45:22.560
<v Speaker 6>form random chance somewhere in the universe, I think is

0:45:22.800 --> 0:45:26.160
<v Speaker 6>a major it's a major misstep in our reasoning.

0:45:25.840 --> 0:45:27.280
<v Speaker 8>About how reality works.

0:45:27.360 --> 0:45:30.000
<v Speaker 6>We have no evidence that it can actually happen outside

0:45:30.000 --> 0:45:33.359
<v Speaker 6>of evolution, and so a lot of people will try

0:45:33.360 --> 0:45:36.440
<v Speaker 6>to challenge the way that we're building the formalism on

0:45:36.560 --> 0:45:39.640
<v Speaker 6>this idea that something complex can just be made on

0:45:39.680 --> 0:45:42.839
<v Speaker 6>a planet in the absence of evolution and selection. And

0:45:43.160 --> 0:45:44.840
<v Speaker 6>I can just say back to that, like, give me

0:45:44.880 --> 0:45:48.759
<v Speaker 6>the evidence the universe builds a me that requires like

0:45:48.840 --> 0:45:51.680
<v Speaker 6>information to specify it, because to me, what that argument

0:45:51.719 --> 0:45:54.600
<v Speaker 6>would entail is actually the equivalent of intelligent designs, as

0:45:54.600 --> 0:45:57.239
<v Speaker 6>the universe has the design of every object at every

0:45:57.280 --> 0:46:01.120
<v Speaker 6>point in the universe. What I'm suggesting is that selection

0:46:01.160 --> 0:46:04.320
<v Speaker 6>and evolution are required to build information specific to objects

0:46:04.360 --> 0:46:06.040
<v Speaker 6>before they can exist.

0:46:05.760 --> 0:46:08.719
<v Speaker 1>Right, And I agree with that. I'm not arguing that

0:46:09.400 --> 0:46:11.960
<v Speaker 1>cell phones should appear on Mars, so that would be probable,

0:46:12.320 --> 0:46:15.239
<v Speaker 1>and I appreciate that. You know, complexity comes as like

0:46:15.280 --> 0:46:17.520
<v Speaker 1>the tip of the pyramid built on the base of

0:46:17.600 --> 0:46:21.000
<v Speaker 1>like a huge amount of things that came before it. Absolutely,

0:46:21.280 --> 0:46:24.200
<v Speaker 1>But what I'm wondering is whether we can argue that

0:46:24.360 --> 0:46:28.400
<v Speaker 1>life on Earth is unusually complex. We don't know with

0:46:28.440 --> 0:46:30.799
<v Speaker 1>the space of possibilities is maybe if we go out

0:46:30.840 --> 0:46:33.720
<v Speaker 1>in the universe we discover, wow, we're actually quite primitive.

0:46:34.040 --> 0:46:37.120
<v Speaker 1>Complexity here on Earth is where in the backwater, I

0:46:37.160 --> 0:46:40.080
<v Speaker 1>mean compared to Mars. Sure, but like you were saying that,

0:46:40.360 --> 0:46:42.560
<v Speaker 1>you know, what we've achieved here on Earth or what's

0:46:42.560 --> 0:46:45.640
<v Speaker 1>happened here on Earth is unusually complex. But how do

0:46:45.680 --> 0:46:46.080
<v Speaker 1>we know that?

0:46:46.440 --> 0:46:47.520
<v Speaker 8>Oh, where's the prior?

0:46:47.680 --> 0:46:50.239
<v Speaker 6>I see, so I was referencing that with respect to

0:46:50.280 --> 0:46:54.279
<v Speaker 6>an abiotic prior. Imagine you don't have an evolutionary system, right,

0:46:54.320 --> 0:46:56.399
<v Speaker 6>So I think we're talking cross purposes about the question.

0:46:56.480 --> 0:46:58.080
<v Speaker 6>So I just want to kind of frame it precisely.

0:46:58.120 --> 0:47:00.200
<v Speaker 6>So if you just look at you know, so a

0:47:00.239 --> 0:47:05.440
<v Speaker 6>system that doesn't have evolutionary selection, the sort of framing

0:47:05.480 --> 0:47:08.560
<v Speaker 6>that we have the key conjectures, there's a maximum complexity

0:47:08.840 --> 0:47:10.839
<v Speaker 6>a non living system could build, and it can't build

0:47:10.840 --> 0:47:13.480
<v Speaker 6>any more than that until selection and sort of feedback

0:47:13.480 --> 0:47:16.360
<v Speaker 6>on the structure and self reproducing systems emerge. That actually

0:47:16.360 --> 0:47:18.799
<v Speaker 6>constrain themselves to be able to perpetuate.

0:47:18.880 --> 0:47:19.040
<v Speaker 8>Right.

0:47:19.640 --> 0:47:23.040
<v Speaker 6>What you're asking is, if that process starts, are we

0:47:23.080 --> 0:47:26.160
<v Speaker 6>more or less complex than that typical process? And I

0:47:26.200 --> 0:47:28.840
<v Speaker 6>think we don't know the answer to that obviously, but

0:47:28.960 --> 0:47:33.279
<v Speaker 6>I think what I can say is from the sort

0:47:33.280 --> 0:47:37.680
<v Speaker 6>of structure of the physical laws in the theory that

0:47:37.840 --> 0:47:43.360
<v Speaker 6>we're building and testing, every evolutionary system will have to

0:47:43.920 --> 0:47:47.759
<v Speaker 6>climb the ladder of complexity, so there is no major

0:47:47.840 --> 0:47:49.279
<v Speaker 6>jump where you just get to be like the most

0:47:49.320 --> 0:47:51.680
<v Speaker 6>complex thing in the universe by skipping steps. So that

0:47:51.719 --> 0:47:54.920
<v Speaker 6>becomes a question of did life start in the universe

0:47:54.960 --> 0:47:58.040
<v Speaker 6>on any planets much before us or have an accelerated

0:47:58.080 --> 0:48:03.080
<v Speaker 6>process moving through the sort of complexity cascade. And I

0:48:03.080 --> 0:48:06.000
<v Speaker 6>don't think anyone knows the answer to that question. That's

0:48:06.000 --> 0:48:07.520
<v Speaker 6>one of the reasons that we want to understand this

0:48:07.560 --> 0:48:10.319
<v Speaker 6>physics so we can actually make predictions about what that

0:48:10.360 --> 0:48:13.239
<v Speaker 6>process looks like on other planets. And I think we're

0:48:13.239 --> 0:48:16.000
<v Speaker 6>at this stage where I'm hopeful, you know, in the

0:48:16.040 --> 0:48:18.320
<v Speaker 6>next I don't know, ten years, maybe we might be

0:48:18.360 --> 0:48:20.600
<v Speaker 6>able to say something meaningful about the first steps from

0:48:20.640 --> 0:48:24.359
<v Speaker 6>geochemistry using this kind of theoretical construction like these kind

0:48:24.360 --> 0:48:26.320
<v Speaker 6>of steps about like what are the first mechanisms of

0:48:26.360 --> 0:48:28.399
<v Speaker 6>selection that emerge in chemistry and what do they look

0:48:28.440 --> 0:48:31.160
<v Speaker 6>like in different planetary contexts. But saying something about that

0:48:31.200 --> 0:48:35.840
<v Speaker 6>whole cascade is basically simulating the entire evolutionary process, you know,

0:48:35.920 --> 0:48:40.600
<v Speaker 6>from the geochemical original life into technology on another planet.

0:48:40.600 --> 0:48:42.880
<v Speaker 6>And I don't think that's actually computationally feasible. I think

0:48:42.920 --> 0:48:44.920
<v Speaker 6>we have to discover other life to answer that question,

0:48:45.680 --> 0:48:47.120
<v Speaker 6>which is why we need a theory to know what

0:48:47.120 --> 0:48:47.719
<v Speaker 6>we're looking for.

0:48:48.080 --> 0:48:52.040
<v Speaker 5>So would geologists come across molecules that look complicated or

0:48:52.160 --> 0:48:53.799
<v Speaker 5>in chemistry? Was the class I did not get?

0:48:53.840 --> 0:48:56.720
<v Speaker 3>As in, yeah, so how do you know that you've got.

0:48:56.520 --> 0:48:58.960
<v Speaker 5>Like a complicated molecule that's life or do you get

0:48:59.040 --> 0:49:02.120
<v Speaker 5>similarly complicated molecules in a geology lab that.

0:49:02.080 --> 0:49:02.640
<v Speaker 3>Are not alive.

0:49:02.840 --> 0:49:06.400
<v Speaker 6>It's a non trivial question, highly non trivial, and I

0:49:06.440 --> 0:49:08.759
<v Speaker 6>think part of it comes from the different uses of

0:49:08.760 --> 0:49:11.719
<v Speaker 6>the word complexity. So I think a lot of my

0:49:11.800 --> 0:49:14.759
<v Speaker 6>planetary science colleagues and geologist would say, of course we

0:49:14.760 --> 0:49:16.960
<v Speaker 6>find complexity in chemical systems.

0:49:16.960 --> 0:49:17.920
<v Speaker 8>We see it all the time.

0:49:18.320 --> 0:49:20.640
<v Speaker 6>The kind of complexity that they're talking about is often

0:49:20.680 --> 0:49:23.480
<v Speaker 6>what we see in prevotic chemistry experiments also, which is

0:49:24.239 --> 0:49:27.760
<v Speaker 6>oftentimes like the most problematic thing you see in prevatic chemistries.

0:49:27.760 --> 0:49:30.279
<v Speaker 6>If you just run an unconstrained reaction, you get what

0:49:30.320 --> 0:49:33.279
<v Speaker 6>we call a tar, which is a non differentiated mess

0:49:33.280 --> 0:49:37.319
<v Speaker 6>of molecules. So these kind of systems can generate a

0:49:37.400 --> 0:49:40.600
<v Speaker 6>lot of molecular diversity, but it tends to be things

0:49:41.120 --> 0:49:45.200
<v Speaker 6>that would be low complexity as individual molecules, and for

0:49:45.280 --> 0:49:47.200
<v Speaker 6>things that are higher complexity, you don't see a lot

0:49:47.200 --> 0:49:50.560
<v Speaker 6>of them. And that's very different than what we see

0:49:50.600 --> 0:49:53.239
<v Speaker 6>in life, which is we see, you know, there's a

0:49:53.280 --> 0:49:55.440
<v Speaker 6>lot of diversity and molecules in life, but compared to

0:49:55.520 --> 0:49:58.040
<v Speaker 6>the size of the chemical space that that could be

0:49:58.120 --> 0:50:02.160
<v Speaker 6>you know, equivalent structure like molecule or way, or you know,

0:50:02.400 --> 0:50:05.240
<v Speaker 6>number of chiral centers or you know, number of elements

0:50:05.239 --> 0:50:07.200
<v Speaker 6>in the molecule, like any of these features you might

0:50:07.239 --> 0:50:11.200
<v Speaker 6>say is equivalent molecules. You see very very very very

0:50:11.239 --> 0:50:15.000
<v Speaker 6>low diversity in biology. And so what biology does is

0:50:15.000 --> 0:50:18.840
<v Speaker 6>it builds molecules that are deep in the space of chemistry,

0:50:18.880 --> 0:50:20.560
<v Speaker 6>like they require a lot of parts to build the

0:50:20.600 --> 0:50:25.120
<v Speaker 6>specific molecule, so that molecule is complex in an evolutionary sense,

0:50:25.680 --> 0:50:28.560
<v Speaker 6>it's found in high abundance, but there's not a huge

0:50:28.560 --> 0:50:31.239
<v Speaker 6>diversity of exploring in an unconstrained way the space of

0:50:31.239 --> 0:50:35.319
<v Speaker 6>all molecules. So I think the kind of complexity we

0:50:35.400 --> 0:50:39.239
<v Speaker 6>talk about in a planetary science sense doesn't discover the

0:50:39.320 --> 0:50:41.160
<v Speaker 6>kind of complexity that biology generates.

0:50:41.640 --> 0:50:43.920
<v Speaker 1>So let's dig into that a little bit, because I

0:50:43.960 --> 0:50:46.400
<v Speaker 1>think that's really at the core of the argument in

0:50:46.440 --> 0:50:49.920
<v Speaker 1>your book, right, this concept of complexity and how we

0:50:50.000 --> 0:50:52.760
<v Speaker 1>discover it and what it means for life to be complex.

0:50:53.200 --> 0:50:56.600
<v Speaker 1>So you're saying that life is something that uses a

0:50:56.640 --> 0:51:00.400
<v Speaker 1>relatively small number of building blocks but puts them together

0:51:01.120 --> 0:51:04.319
<v Speaker 1>in a way that's very complex. Right. The complexity comes

0:51:04.320 --> 0:51:06.840
<v Speaker 1>from the arrangements of a few bits, not from the

0:51:07.160 --> 0:51:11.080
<v Speaker 1>inherent complexity of the pieces, and that we of the

0:51:11.200 --> 0:51:13.960
<v Speaker 1>chemical space that exists out there. As you're saying earlier,

0:51:14.360 --> 0:51:17.480
<v Speaker 1>it uses a tiny, little, very tiny, yeah, very tiny,

0:51:17.480 --> 0:51:20.880
<v Speaker 1>little aspect of that. And so again I wonder, like,

0:51:21.440 --> 0:51:24.319
<v Speaker 1>how do we know how unusual that is, or how

0:51:24.320 --> 0:51:26.640
<v Speaker 1>special that is, how distinct that is? How do we

0:51:26.680 --> 0:51:30.280
<v Speaker 1>know that it's not possible using other building blocks to

0:51:30.320 --> 0:51:32.920
<v Speaker 1>create complexity? How do we know that complexity doesn't always

0:51:32.920 --> 0:51:36.040
<v Speaker 1>arise if you start from you know, basic bits.

0:51:36.520 --> 0:51:39.240
<v Speaker 6>Yeah, this is the more exciting question, and it's actually,

0:51:39.480 --> 0:51:42.120
<v Speaker 6>you know, the one experimentally, I'm really interested in. If

0:51:42.160 --> 0:51:45.799
<v Speaker 6>you designed an original life experiment that was modeling a

0:51:45.800 --> 0:51:51.000
<v Speaker 6>planetary environment and it was unconstrained and selection and evolutionary

0:51:51.040 --> 0:51:54.120
<v Speaker 6>processes emerged in the system just by the dynamics of

0:51:54.120 --> 0:51:57.720
<v Speaker 6>the chemistry, would it discover the same biochemistry?

0:51:58.120 --> 0:51:59.440
<v Speaker 8>And I'm not convinced it would.

0:51:59.440 --> 0:52:01.719
<v Speaker 6>I think space is so large that there are a

0:52:01.800 --> 0:52:05.040
<v Speaker 6>lot of potential chemical architectures for life that could be

0:52:05.120 --> 0:52:10.120
<v Speaker 6>quite different, but we haven't discovered them yet. Because life

0:52:10.120 --> 0:52:13.600
<v Speaker 6>on Earth, you know, had one solution that allowed it

0:52:13.680 --> 0:52:17.680
<v Speaker 6>to perpetuate itself and had to use that architecture for

0:52:17.719 --> 0:52:20.600
<v Speaker 6>billions of years. And you know, the question is if

0:52:20.600 --> 0:52:22.480
<v Speaker 6>the original life happened again, would it discover the same

0:52:22.560 --> 0:52:23.279
<v Speaker 6>architecture or not?

0:52:23.680 --> 0:52:24.960
<v Speaker 8>And nobody knows the answer to that.

0:52:25.200 --> 0:52:28.600
<v Speaker 6>I think that's an experimental question, you know, and that's

0:52:28.640 --> 0:52:30.719
<v Speaker 6>one that we want to ask because you know, part

0:52:30.719 --> 0:52:33.000
<v Speaker 6>of the thing I you know, try to really highlight

0:52:33.520 --> 0:52:35.279
<v Speaker 6>in the discussion in the book, but I'm also really

0:52:35.320 --> 0:52:37.960
<v Speaker 6>trying to just pitch to people as an experimental program

0:52:38.000 --> 0:52:39.719
<v Speaker 6>that we need to do because it requires a lot

0:52:39.719 --> 0:52:43.160
<v Speaker 6>of investment of technology and resources, is to think through

0:52:43.320 --> 0:52:46.120
<v Speaker 6>how we would build an experimental program to discover alien life.

0:52:46.040 --> 0:52:49.799
<v Speaker 8>In the lab and the idea of Eric exactly in

0:52:49.840 --> 0:52:50.279
<v Speaker 8>the lab.

0:52:51.120 --> 0:52:53.359
<v Speaker 6>Yes, it's exactly what you're saying though, like we don't

0:52:53.400 --> 0:52:56.080
<v Speaker 6>know if life could exist in other chemistries. If you

0:52:56.200 --> 0:52:59.080
<v Speaker 6>do a proper original life experiment and you really want

0:52:59.120 --> 0:53:02.240
<v Speaker 6>to know the spontaneous probability for a universe to generate life,

0:53:02.280 --> 0:53:04.480
<v Speaker 6>you can't just cherry pick and use them like our

0:53:04.480 --> 0:53:06.279
<v Speaker 6>structures that were selected on Earth and say I'm going

0:53:06.320 --> 0:53:09.480
<v Speaker 6>to make these because you're inducing selection based on what

0:53:09.600 --> 0:53:12.560
<v Speaker 6>was produced on Earth right prior knowledge of it. You

0:53:12.640 --> 0:53:15.200
<v Speaker 6>really want to see from chemistry what would it generate

0:53:16.800 --> 0:53:20.640
<v Speaker 6>without any intervention from us, as you know, designers of

0:53:20.680 --> 0:53:23.279
<v Speaker 6>the chemistry, knowing what we know of Earth life. So

0:53:23.320 --> 0:53:26.440
<v Speaker 6>I think the original life problem is actually that's exactly

0:53:26.440 --> 0:53:30.560
<v Speaker 6>what it is, is an experimental problem to try to

0:53:30.600 --> 0:53:36.200
<v Speaker 6>discover what is the mechanism chemistry generates living forms. And

0:53:36.680 --> 0:53:39.400
<v Speaker 6>if you know that mechanism, is it universally going to

0:53:39.400 --> 0:53:41.480
<v Speaker 6>converge on what life on Earth did? Or are there

0:53:41.560 --> 0:53:43.520
<v Speaker 6>many solutions because this space is so huge.

0:53:44.000 --> 0:53:46.200
<v Speaker 3>I'm sure you could get a lot of evolutionary biologies

0:53:46.320 --> 0:53:49.520
<v Speaker 3>very excited if you could repeatedly generate them.

0:53:49.640 --> 0:53:53.640
<v Speaker 8>You need their talent, so that's good. Yeah, I think

0:53:53.800 --> 0:53:53.960
<v Speaker 8>you know.

0:53:54.000 --> 0:53:56.719
<v Speaker 6>Part of my motivation with right, it's hard to write

0:53:56.719 --> 0:53:59.879
<v Speaker 6>a book, right, And for first and foremost, I'm about

0:53:59.880 --> 0:54:01.520
<v Speaker 6>this science, like I just really want to solve the

0:54:01.560 --> 0:54:03.279
<v Speaker 6>original life. So part of my motivation is to get

0:54:03.320 --> 0:54:06.439
<v Speaker 6>people excited about like what are the actual critical challenges here?

0:54:06.480 --> 0:54:09.399
<v Speaker 6>And I think this one is like the main one

0:54:09.600 --> 0:54:11.719
<v Speaker 6>is like what does the experimental program look like that

0:54:11.760 --> 0:54:14.360
<v Speaker 6>solves the original life? And how related is it to

0:54:14.400 --> 0:54:16.600
<v Speaker 6>all these other questions that we're talking about. And for me,

0:54:17.360 --> 0:54:20.880
<v Speaker 6>it is going to require you know, really intense technological infrastructure,

0:54:20.880 --> 0:54:25.560
<v Speaker 6>building digital chemistry and AI driven robotic chemistry to actually

0:54:25.640 --> 0:54:28.760
<v Speaker 6>search chemical space like a search engine, and then looking

0:54:28.800 --> 0:54:31.640
<v Speaker 6>for these kind of chemistries and when they undergo selection

0:54:31.719 --> 0:54:34.200
<v Speaker 6>and they start emerging things that we might call life.

0:54:34.280 --> 0:54:37.520
<v Speaker 6>And the reason for having to build a theory in

0:54:37.560 --> 0:54:40.279
<v Speaker 6>part besides all the reasons I have as a physicist,

0:54:40.480 --> 0:54:42.320
<v Speaker 6>is if the chemistry is radically different, how do you

0:54:42.400 --> 0:54:44.400
<v Speaker 6>even know it's a living thing, and so we have

0:54:44.480 --> 0:54:47.799
<v Speaker 6>to be able to measure evolution in molecules agnostic to

0:54:48.000 --> 0:54:52.359
<v Speaker 6>what molecules evolution creates, and know that they have a

0:54:52.400 --> 0:54:57.319
<v Speaker 6>comparable level of selection in them to say that, you know,

0:54:57.400 --> 0:54:59.640
<v Speaker 6>this is past the threshold that we expect it to

0:54:59.640 --> 0:55:03.080
<v Speaker 6>be a live form versus you know what, we expect

0:55:03.360 --> 0:55:06.440
<v Speaker 6>a big systems that aren't evolving to be able to generate.

0:55:06.800 --> 0:55:08.480
<v Speaker 1>And so this is sort of the core argument of

0:55:08.520 --> 0:55:12.160
<v Speaker 1>your book. You describe assembly theory, where you measure the

0:55:12.200 --> 0:55:15.440
<v Speaker 1>complexity of something as the number of steps it takes

0:55:15.520 --> 0:55:17.520
<v Speaker 1>essentially to build some of the shortest path to go

0:55:17.680 --> 0:55:21.359
<v Speaker 1>from building blocks to this thing, right, and then you

0:55:21.840 --> 0:55:24.200
<v Speaker 1>do this thing where you say, well, anything above fifteen

0:55:24.239 --> 0:55:27.720
<v Speaker 1>steps is life, and anything below fifteen steps is not life.

0:55:28.239 --> 0:55:30.520
<v Speaker 1>And I was with you until I got to that point.

0:55:30.640 --> 0:55:32.839
<v Speaker 1>I found myself asking, as you actually did in the book,

0:55:32.880 --> 0:55:37.120
<v Speaker 1>like well, why fifteen doesn't it feel sort of arbitrary?

0:55:37.640 --> 0:55:38.680
<v Speaker 1>How do we know it's fifteen?

0:55:38.760 --> 0:55:41.640
<v Speaker 8>It's like it should be forty two, right, forty two

0:55:41.680 --> 0:55:42.399
<v Speaker 8>would have been better?

0:55:42.520 --> 0:55:44.960
<v Speaker 1>Yeah, gives a description of that thought process.

0:55:45.120 --> 0:55:46.000
<v Speaker 8>No, it's a good question.

0:55:46.080 --> 0:55:49.359
<v Speaker 6>So fifteen is maybe an approximate bound, right, But where

0:55:49.400 --> 0:55:52.040
<v Speaker 6>that comes from is actually the experimental data. So it's

0:55:52.040 --> 0:55:55.000
<v Speaker 6>not like anointed, you know, like the assembly theory cult

0:55:55.000 --> 0:55:56.160
<v Speaker 6>said it's going to be fifteen.

0:55:56.200 --> 0:55:57.759
<v Speaker 8>It's just like, you know, we build it.

0:55:57.840 --> 0:55:58.960
<v Speaker 1>How do I do any cult?

0:55:59.320 --> 0:55:59.560
<v Speaker 4>I know?

0:55:59.640 --> 0:55:59.839
<v Speaker 1>Right?

0:56:00.760 --> 0:56:03.120
<v Speaker 6>And there is no cult actually, Like it's really funny

0:56:03.120 --> 0:56:05.960
<v Speaker 6>because you know, there's a lot of challenges we're getting

0:56:05.960 --> 0:56:08.520
<v Speaker 6>developing this theory from people picking it apart different ways,

0:56:08.520 --> 0:56:10.440
<v Speaker 6>which we love, but I don't think anyone's harder on

0:56:10.480 --> 0:56:12.200
<v Speaker 6>it than the people we have actually working on it.

0:56:12.280 --> 0:56:14.760
<v Speaker 8>So it's like, which is the best kind of science?

0:56:14.840 --> 0:56:16.440
<v Speaker 6>Right, Like you pick apart every idea and you re

0:56:16.520 --> 0:56:18.440
<v Speaker 6>evaluate everything you're doing at every step.

0:56:18.480 --> 0:56:20.440
<v Speaker 1>Well, if you're denying the existence of the cult, that

0:56:20.440 --> 0:56:22.160
<v Speaker 1>tells me that the cult definitely exists.

0:56:22.200 --> 0:56:24.359
<v Speaker 8>Oh sure, yeah, I know right, you're just I'm going

0:56:24.400 --> 0:56:25.279
<v Speaker 8>to wink link wink.

0:56:27.239 --> 0:56:29.359
<v Speaker 1>Tell us about the data that supports the choices.

0:56:29.520 --> 0:56:31.440
<v Speaker 8>Yeah, so that comes from the data.

0:56:31.480 --> 0:56:34.640
<v Speaker 6>So this idea of this minimal past, so it involves

0:56:34.680 --> 0:56:36.880
<v Speaker 6>you recursions. So the idea is like it's easier with

0:56:37.160 --> 0:56:39.840
<v Speaker 6>lego than chemistry, you know, because most of us aren't chemists.

0:56:39.840 --> 0:56:43.160
<v Speaker 6>So it's like you think you're building a particular lego structure.

0:56:43.280 --> 0:56:45.160
<v Speaker 6>I usually use Howkwarts castle with people know, but like

0:56:45.200 --> 0:56:47.600
<v Speaker 6>the taj Ma hall or whatever you know, building you

0:56:47.680 --> 0:56:50.680
<v Speaker 6>might prefer, you know, you wouldn't expect to form it

0:56:50.719 --> 0:56:52.640
<v Speaker 6>by randomly shaking the building blocks in the box.

0:56:52.719 --> 0:56:54.640
<v Speaker 8>Right, there's instructions that allow you to make it. In

0:56:54.719 --> 0:56:56.839
<v Speaker 8>assembly theory, you realize.

0:56:56.560 --> 0:56:58.600
<v Speaker 6>If you take the instructions, there's actually lots of different

0:56:58.600 --> 0:57:00.880
<v Speaker 6>ways of getting to the end if you don't use

0:57:00.880 --> 0:57:03.120
<v Speaker 6>the instructions. Right, So in assembly theory we have to

0:57:03.160 --> 0:57:06.880
<v Speaker 6>ground it in something that's always there about that structure,

0:57:06.960 --> 0:57:09.160
<v Speaker 6>and not just because you had a particular set of

0:57:09.200 --> 0:57:12.319
<v Speaker 6>instructions in a particular environment to make that. And so

0:57:12.640 --> 0:57:15.040
<v Speaker 6>we do this based on this minimal path idea. And

0:57:15.160 --> 0:57:17.720
<v Speaker 6>the assumptions of the minimal path are you can only

0:57:17.720 --> 0:57:20.080
<v Speaker 6>build things if you already build them, and you want

0:57:20.080 --> 0:57:22.400
<v Speaker 6>to try to find the shortest path where you're reusing

0:57:22.440 --> 0:57:24.560
<v Speaker 6>parts you've built already to build the final structure.

0:57:24.720 --> 0:57:26.240
<v Speaker 8>So very minimal set of assumptions.

0:57:26.920 --> 0:57:30.840
<v Speaker 6>It turns out that feature you can actually measure in

0:57:30.880 --> 0:57:33.320
<v Speaker 6>the lab, and we measured it in the paper that

0:57:33.360 --> 0:57:37.400
<v Speaker 6>we tried to do biosignature validation in using mass spectrometry,

0:57:37.440 --> 0:57:39.440
<v Speaker 6>But there was a later paper from Leekronin's group that

0:57:39.480 --> 0:57:42.160
<v Speaker 6>came out showing that you can also measure assembly index

0:57:42.600 --> 0:57:44.880
<v Speaker 6>this shortest path measure with NMR and infrared.

0:57:45.280 --> 0:57:47.200
<v Speaker 8>So we have a strong sort of.

0:57:47.200 --> 0:57:50.439
<v Speaker 6>Conviction right now as a RUNN assumption with a theory

0:57:50.440 --> 0:57:53.080
<v Speaker 6>that it's an intrinsic property of a molecule, this feature,

0:57:53.120 --> 0:57:56.560
<v Speaker 6>it's one that you can measure with independent measuring apparatus.

0:57:56.560 --> 0:57:58.640
<v Speaker 6>It doesn't depend on where the environment where the molecule

0:57:58.720 --> 0:58:01.960
<v Speaker 6>was made. That gives us some of the baseline criteria

0:58:02.040 --> 0:58:04.240
<v Speaker 6>of something being an objective measure of the amount of

0:58:04.280 --> 0:58:07.280
<v Speaker 6>selection in an object. And then what you have in

0:58:07.320 --> 0:58:10.120
<v Speaker 6>a molecule that you can go and measure in the lab.

0:58:10.280 --> 0:58:12.840
<v Speaker 6>So you know, if I went to Enceladus and I

0:58:12.960 --> 0:58:14.920
<v Speaker 6>measured it, you know the molecule would have the same

0:58:15.000 --> 0:58:16.040
<v Speaker 6>value it would have on Earth.

0:58:16.640 --> 0:58:19.720
<v Speaker 8>Okay, so that's important. And so the question is then

0:58:20.000 --> 0:58:20.840
<v Speaker 8>if you use.

0:58:20.720 --> 0:58:25.200
<v Speaker 6>That, does it actually separate out things that are uniquely

0:58:25.200 --> 0:58:28.080
<v Speaker 6>produced by life from not? And so to do this,

0:58:28.680 --> 0:58:32.680
<v Speaker 6>Lee's lab took a bunch of samples, you know, abiotic

0:58:32.800 --> 0:58:35.919
<v Speaker 6>and biotic, even some Scotch whiskey, and then they had

0:58:35.920 --> 0:58:39.720
<v Speaker 6>some samples that were blinded from NASA that were both

0:58:39.760 --> 0:58:42.720
<v Speaker 6>biological and non biological, sort of an adversarial test case.

0:58:43.080 --> 0:58:45.040
<v Speaker 6>And what they did is they use this mass spect

0:58:45.040 --> 0:58:48.720
<v Speaker 6>method to measure assembly index on the actual samples, and

0:58:48.760 --> 0:58:52.640
<v Speaker 6>they showed that using assembly theory combined with the mass

0:58:52.640 --> 0:58:59.800
<v Speaker 6>spect data, they only saw molecules that were more than

0:58:59.840 --> 0:59:04.320
<v Speaker 6>fifteen steps in this minimal path being produced by living samples.

0:59:04.880 --> 0:59:08.080
<v Speaker 6>And this gets to the complicated versus complexity issue because

0:59:08.120 --> 0:59:11.200
<v Speaker 6>one of the adversarial samples that NASA cent was actually

0:59:11.400 --> 0:59:15.760
<v Speaker 6>Murchison meteorite, which oftentimes in prebatic chemistry literature you will

0:59:15.760 --> 0:59:19.200
<v Speaker 6>see as being like the most complex sample of prebatic chemistry,

0:59:19.400 --> 0:59:23.080
<v Speaker 6>and it was still below fifteen for the molecules in

0:59:23.120 --> 0:59:26.320
<v Speaker 6>the sample. So what you see Murchison is again this tar.

0:59:26.480 --> 0:59:28.440
<v Speaker 6>You have a lot of molecules, but none of them

0:59:28.440 --> 0:59:32.720
<v Speaker 6>are high abundance and a high assembly. And so it's

0:59:32.760 --> 0:59:35.320
<v Speaker 6>not just that the molecule is high assembly. You actually

0:59:35.400 --> 0:59:39.360
<v Speaker 6>have to have it in a high enough abundance to

0:59:39.400 --> 0:59:42.720
<v Speaker 6>say that it was selected in that particular context.

0:59:42.800 --> 0:59:45.400
<v Speaker 1>Right, So, but does that mean that if I find

0:59:45.400 --> 0:59:48.440
<v Speaker 1>some sample on an alien planet and you measure its

0:59:48.440 --> 0:59:51.080
<v Speaker 1>assembly index and it comes out to forty two, You're

0:59:51.080 --> 0:59:53.440
<v Speaker 1>going to be like, this is life? Are you proposing

0:59:53.480 --> 0:59:56.880
<v Speaker 1>this as a definition of life? A discrow way to decide?

0:59:57.400 --> 0:59:59.920
<v Speaker 6>I think that would be the ultimate outcome based on

1:00:00.080 --> 1:00:01.600
<v Speaker 6>the path that we're on, but I think we have

1:00:01.640 --> 1:00:04.280
<v Speaker 6>a lot more work to do to be like definitively

1:00:04.360 --> 1:00:07.440
<v Speaker 6>there is a threshold and assembly spaces above which you

1:00:07.520 --> 1:00:10.800
<v Speaker 6>would say that a sample was life or not.

1:00:10.920 --> 1:00:12.280
<v Speaker 8>And that's sort of where we're going.

1:00:12.280 --> 1:00:14.000
<v Speaker 6>So right now, I would be pretty high confident if

1:00:14.040 --> 1:00:17.960
<v Speaker 6>you discovered something on Enceladus that was forty two that

1:00:18.040 --> 1:00:21.080
<v Speaker 6>it could only be produced by life. But the sort

1:00:21.080 --> 1:00:25.400
<v Speaker 6>of next steps are really actually theoretically predicting why it

1:00:25.400 --> 1:00:28.120
<v Speaker 6>should be the number fifteen and what number it should

1:00:28.120 --> 1:00:30.680
<v Speaker 6>be if you have variations in your elemental distributions or

1:00:30.720 --> 1:00:32.880
<v Speaker 6>other things about the structure of the assembly space, which

1:00:32.920 --> 1:00:35.800
<v Speaker 6>is the underlying mathematical structure that we build this.

1:00:35.760 --> 1:00:36.800
<v Speaker 8>Whole formalism out of.

1:00:37.240 --> 1:00:39.080
<v Speaker 6>And so one of the projects in my lab right

1:00:39.080 --> 1:00:41.760
<v Speaker 6>now is actually trying to quantify why there's a transition

1:00:42.120 --> 1:00:46.200
<v Speaker 6>in assembly theory at the particular assembly index values that

1:00:46.240 --> 1:00:48.760
<v Speaker 6>we see and might see in different systems.

1:00:48.520 --> 1:00:51.040
<v Speaker 1>Because as you say, the chemical space is very large

1:00:51.080 --> 1:00:55.120
<v Speaker 1>and petible, that there's structures out there that are quite

1:00:55.160 --> 1:00:57.480
<v Speaker 1>complex but that nobody would call alive.

1:00:57.800 --> 1:01:01.200
<v Speaker 6>Right, So there are many such structures, right, So it's

1:01:01.240 --> 1:01:03.840
<v Speaker 6>not necessarily that the threshold must be at fifteen.

1:01:03.960 --> 1:01:04.880
<v Speaker 8>That's where we.

1:01:04.840 --> 1:01:07.520
<v Speaker 6>Have for the kinds of chemistry that we test in

1:01:07.640 --> 1:01:11.160
<v Speaker 6>labs so far. When we have a general theory, which

1:01:11.200 --> 1:01:15.040
<v Speaker 6>we're working on very fervently right now with our teams,

1:01:15.640 --> 1:01:18.120
<v Speaker 6>we would be able to predict, based on the sort

1:01:18.120 --> 1:01:20.919
<v Speaker 6>of elemental composition and other features of your chemistry, where

1:01:20.920 --> 1:01:23.439
<v Speaker 6>that threshold should be. And then that allows us further

1:01:23.520 --> 1:01:25.960
<v Speaker 6>tests to really validate that this works in different systems.

1:01:26.280 --> 1:01:28.120
<v Speaker 6>And you know, one place where it might be more

1:01:28.200 --> 1:01:31.360
<v Speaker 6>challenging is actually with minerals because minerals don't uphold all

1:01:31.400 --> 1:01:34.440
<v Speaker 6>of the properties of molecules. They have very different structure,

1:01:34.440 --> 1:01:38.280
<v Speaker 6>but they're also made out of elements bonding and minerals

1:01:38.360 --> 1:01:40.640
<v Speaker 6>because they have very different structure to how you build

1:01:40.680 --> 1:01:43.280
<v Speaker 6>up a mineral in this kind of way that we do,

1:01:43.400 --> 1:01:46.160
<v Speaker 6>this kind of recursive construction and what you would define

1:01:46.200 --> 1:01:48.960
<v Speaker 6>as a repeat in a mineral, they might have a

1:01:49.000 --> 1:01:50.960
<v Speaker 6>you know, a threshold that's much higher than what we

1:01:51.000 --> 1:01:54.760
<v Speaker 6>observe for aqueous molect our chemistry. And so, as with

1:01:54.920 --> 1:01:58.400
<v Speaker 6>any new theory of physics, it's a process of suggesting

1:01:58.400 --> 1:02:00.800
<v Speaker 6>an idea, testing it, iterating on the idea. And so

1:02:01.040 --> 1:02:03.440
<v Speaker 6>you know, the process of theory building doesn't happen overnight.

1:02:03.520 --> 1:02:06.280
<v Speaker 6>It happens over a decade or two. And so these

1:02:06.280 --> 1:02:08.800
<v Speaker 6>are some of the frontier questions that we're asking about, Like,

1:02:08.840 --> 1:02:10.840
<v Speaker 6>you know, is this actually you know the right approach,

1:02:10.920 --> 1:02:13.720
<v Speaker 6>then these things should work out, but we don't know

1:02:13.720 --> 1:02:14.360
<v Speaker 6>the answer yet.

1:02:14.400 --> 1:02:15.400
<v Speaker 8>So that's why it's exciting.

1:02:16.120 --> 1:02:20.880
<v Speaker 5>Sometimes life gets overwhelming, and sometimes conversations about life get overwhelming.

1:02:20.960 --> 1:02:22.920
<v Speaker 5>So I feel like it's time for a break. So

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<v Speaker 1>I hope your brains are arrested and ready for some

1:05:19.960 --> 1:05:25.240
<v Speaker 1>more overwhelming conversation about incredible topics like the physics of life.

1:05:26.240 --> 1:05:28.760
<v Speaker 1>It is exciting. One question I would have in my

1:05:28.800 --> 1:05:30.880
<v Speaker 1>mind if I was working on this is like, whether

1:05:30.920 --> 1:05:33.360
<v Speaker 1>the value is fifteen or nineteen or fourteen or whatever,

1:05:33.520 --> 1:05:35.680
<v Speaker 1>how do we know that all the information is captured

1:05:35.720 --> 1:05:39.040
<v Speaker 1>by this one quantity. You back it up so far

1:05:39.160 --> 1:05:40.760
<v Speaker 1>with like, well, we have a bunch of these examples,

1:05:40.840 --> 1:05:42.960
<v Speaker 1>then it seems to have worked, and you're working on

1:05:43.000 --> 1:05:44.240
<v Speaker 1>the theoretical underpinnings.

1:05:44.720 --> 1:05:44.920
<v Speaker 11>You know.

1:05:45.320 --> 1:05:47.760
<v Speaker 1>I work on machine learning problems all the time where

1:05:47.760 --> 1:05:50.320
<v Speaker 1>we convince ourselves we've learned how to distinguish between A

1:05:50.400 --> 1:05:52.840
<v Speaker 1>and B because we've only seen some kind of examples,

1:05:52.880 --> 1:05:54.760
<v Speaker 1>and then we go off into the world where like, oops,

1:05:54.960 --> 1:05:58.680
<v Speaker 1>turns out that's just one dimension of a multidimensional problem.

1:05:58.760 --> 1:06:03.160
<v Speaker 1>You know, for example, if I was not intelligent about

1:06:03.160 --> 1:06:04.560
<v Speaker 1>this and I said, well, look I took a bunch

1:06:04.560 --> 1:06:06.760
<v Speaker 1>of examples of living things that all have brown hair

1:06:07.200 --> 1:06:09.520
<v Speaker 1>and non living things that don't have brown hair, and

1:06:09.560 --> 1:06:11.440
<v Speaker 1>then I developed my definition of life to be like,

1:06:11.680 --> 1:06:14.560
<v Speaker 1>does it have brown hair? I could also come up

1:06:14.600 --> 1:06:17.240
<v Speaker 1>with a way to distinguish between quote unquote living and

1:06:17.320 --> 1:06:21.080
<v Speaker 1>unliving things because my sample was limited, and here your

1:06:21.120 --> 1:06:23.880
<v Speaker 1>sample is limited because you only have examples from you know,

1:06:24.400 --> 1:06:26.880
<v Speaker 1>life we've seen and so how do I know that

1:06:26.920 --> 1:06:28.640
<v Speaker 1>there is a number that distinguishes.

1:06:29.200 --> 1:06:31.680
<v Speaker 8>So there's a couple of things there.

1:06:31.920 --> 1:06:34.280
<v Speaker 6>One of them is assembly theory is not a scaler theory,

1:06:34.320 --> 1:06:36.400
<v Speaker 6>so it's not just about this number. It's actually about

1:06:36.440 --> 1:06:38.960
<v Speaker 6>also the abundance of objects at different assembly indites.

1:06:39.120 --> 1:06:41.000
<v Speaker 8>So it's higher dimensional than that.

1:06:41.160 --> 1:06:44.400
<v Speaker 6>And the idea is you're talking about selection in this

1:06:44.520 --> 1:06:47.240
<v Speaker 6>massive combinatorial space, and you have to talk about the

1:06:47.240 --> 1:06:50.040
<v Speaker 6>reduction of the size of the space represented in the

1:06:50.040 --> 1:06:53.560
<v Speaker 6>objects you observe. And we have rigorous ways for thinking,

1:06:53.960 --> 1:06:56.360
<v Speaker 6>like based on the mathematical formalism of the theory, why

1:06:56.400 --> 1:06:58.720
<v Speaker 6>we're capturing the relevant features of that reduction of.

1:06:58.720 --> 1:06:59.560
<v Speaker 8>The size of the space.

1:07:00.800 --> 1:07:03.760
<v Speaker 6>People usually do do exactly what you're saying, where they

1:07:03.800 --> 1:07:06.400
<v Speaker 6>try to, you know, separate living and non living things

1:07:06.440 --> 1:07:08.600
<v Speaker 6>and then classify them. And it's becoming very popular in

1:07:08.680 --> 1:07:10.600
<v Speaker 6>natro biology right now to do machine learning on those

1:07:10.680 --> 1:07:13.640
<v Speaker 6>kind of problems. I don't think that that approach is generalizable.

1:07:13.920 --> 1:07:16.160
<v Speaker 6>The reason I have confidence in what we're doing is

1:07:16.160 --> 1:07:19.800
<v Speaker 6>because there's a whole theoretical infrastructure building in a whole

1:07:19.840 --> 1:07:22.240
<v Speaker 6>bunch of ideas about the nature of information in life,

1:07:22.440 --> 1:07:23.600
<v Speaker 6>what is causation in life?

1:07:23.640 --> 1:07:26.280
<v Speaker 8>How do we measure these features in molecules? You know?

1:07:26.400 --> 1:07:28.720
<v Speaker 6>What is it about these emergent properties of life? Like

1:07:28.960 --> 1:07:31.320
<v Speaker 6>you know, I've spent my entire career basically working on

1:07:31.360 --> 1:07:34.560
<v Speaker 6>every kind of biological system imaginable, and you know, Lee's

1:07:34.600 --> 1:07:36.920
<v Speaker 6>lab has worked on kind of every chemical system imaginable,

1:07:36.960 --> 1:07:39.920
<v Speaker 6>and putting all of that knowledge into one theoretical structure

1:07:40.000 --> 1:07:42.040
<v Speaker 6>that we can really stand behind and say, this captures

1:07:42.040 --> 1:07:44.760
<v Speaker 6>the features we think are important, and we can measure it,

1:07:45.160 --> 1:07:47.160
<v Speaker 6>and we want to test it by actually building living

1:07:47.200 --> 1:07:50.640
<v Speaker 6>things in the lab. So it's not ever going to

1:07:50.640 --> 1:07:53.440
<v Speaker 6>be convinced by just this measure and the copy number.

1:07:53.440 --> 1:07:56.680
<v Speaker 6>What you get convinced of is an explanatory paradigm that

1:07:56.800 --> 1:07:59.240
<v Speaker 6>allows you to explain not just this one data set,

1:07:59.240 --> 1:08:02.200
<v Speaker 6>but a whole bunch of different things, And so ultimately

1:08:02.240 --> 1:08:03.560
<v Speaker 6>the proof of the theory is going to come from

1:08:03.600 --> 1:08:07.120
<v Speaker 6>the generalizability and the new questions it allows us to answer.

1:08:07.560 --> 1:08:11.360
<v Speaker 6>Not what we've done so far, so't I wouldn't hang

1:08:11.360 --> 1:08:13.000
<v Speaker 6>my hat on it the data we have so far.

1:08:13.040 --> 1:08:15.960
<v Speaker 6>But what I'm hanging my hat on is the potential

1:08:15.960 --> 1:08:18.280
<v Speaker 6>things that this is opening up and the way it's

1:08:18.320 --> 1:08:20.639
<v Speaker 6>allowing a unified explanation for a whole bunch of problems

1:08:20.680 --> 1:08:24.600
<v Speaker 6>in astrobiology that have traditionally been considered completely separate. And

1:08:24.680 --> 1:08:26.799
<v Speaker 6>also on what we talked about at the very beginning

1:08:26.880 --> 1:08:30.760
<v Speaker 6>about what is physics and what does physics do? And

1:08:30.800 --> 1:08:33.160
<v Speaker 6>for me, it's about the explanation for the nature of

1:08:33.200 --> 1:08:35.400
<v Speaker 6>life that's more important than anyone experiment.

1:08:35.880 --> 1:08:37.519
<v Speaker 3>That feels like a nice note to end things on,

1:08:38.000 --> 1:08:41.320
<v Speaker 3>like a nice wrap up is did you have another question, Daniel.

1:08:41.200 --> 1:08:45.120
<v Speaker 1>Yeah, I would love to hear just as a final vision,

1:08:45.280 --> 1:08:47.880
<v Speaker 1>like how you think this could, in the best case

1:08:47.920 --> 1:08:51.200
<v Speaker 1>scenario come together like you talk in the book about

1:08:51.920 --> 1:08:55.160
<v Speaker 1>building these computers, how you search for the origin of

1:08:55.200 --> 1:08:57.639
<v Speaker 1>life and when I do science, I was trying to imagine,

1:08:57.680 --> 1:09:00.760
<v Speaker 1>like what's the fantasy data I would have, Are you

1:09:00.800 --> 1:09:03.599
<v Speaker 1>hoping that we discover like alien life here on Earth

1:09:03.720 --> 1:09:06.599
<v Speaker 1>before we discover it on Enzi? Let us would actually

1:09:06.680 --> 1:09:09.800
<v Speaker 1>be your preference? Take us through your scientific fantasy, right.

1:09:09.960 --> 1:09:12.800
<v Speaker 6>So my preference is that we just discover more life

1:09:12.800 --> 1:09:14.840
<v Speaker 6>and we understand what life is. So my preference is

1:09:15.400 --> 1:09:19.760
<v Speaker 6>understand what life is and have enough scientific evidence to

1:09:19.800 --> 1:09:23.280
<v Speaker 6>support that explanation. The progress of science is that's never

1:09:23.320 --> 1:09:26.400
<v Speaker 6>a single aha moment. It's like, you know, a cultural transformation,

1:09:26.439 --> 1:09:28.240
<v Speaker 6>and the way we understand a certain set of phenomena

1:09:28.320 --> 1:09:31.320
<v Speaker 6>mediated by a whole bunch of experiments and observations and

1:09:31.360 --> 1:09:34.400
<v Speaker 6>a consilience of like a whole bunch of things coming together. Right,

1:09:34.439 --> 1:09:37.519
<v Speaker 6>So I think that process is highly nonlinear. For me,

1:09:37.600 --> 1:09:41.960
<v Speaker 6>the reason I really advocated more for this experimental approach

1:09:42.439 --> 1:09:44.839
<v Speaker 6>in the lab is the idea that you could iterate

1:09:44.920 --> 1:09:48.360
<v Speaker 6>between the observation and theory very quickly. So the challenge

1:09:48.360 --> 1:09:51.439
<v Speaker 6>for looking for life on alien worlds is we don't

1:09:51.479 --> 1:09:53.559
<v Speaker 6>know the prior probability for life, and we don't know

1:09:53.560 --> 1:09:56.439
<v Speaker 6>what we're looking for, and so we don't know how

1:09:56.520 --> 1:09:58.880
<v Speaker 6>many planets we have to survey before we find something.

1:09:58.920 --> 1:10:00.479
<v Speaker 6>And nor is it the case that we can actually

1:10:00.520 --> 1:10:03.000
<v Speaker 6>rule out a planet is alive or not. And so

1:10:03.120 --> 1:10:05.639
<v Speaker 6>I think by trying to bring the paradigm of looking

1:10:05.640 --> 1:10:08.639
<v Speaker 6>for alien life into an experimental paradigm, and when we

1:10:08.640 --> 1:10:11.320
<v Speaker 6>were actually building large enough chemical search engines to look

1:10:11.320 --> 1:10:14.639
<v Speaker 6>for alien life, we actually make it tractable to understand

1:10:14.640 --> 1:10:18.360
<v Speaker 6>the mechanism of the original life, the probability it doesn't happen,

1:10:18.800 --> 1:10:21.080
<v Speaker 6>and also build the theory and experiments to really test

1:10:21.120 --> 1:10:23.080
<v Speaker 6>how it does happen at the same time. So to me,

1:10:23.200 --> 1:10:25.160
<v Speaker 6>it seems the most efficient route to get actually getting

1:10:25.200 --> 1:10:28.519
<v Speaker 6>to the answer to the question. And so and you know,

1:10:28.600 --> 1:10:30.439
<v Speaker 6>part of it might be biased by my background in

1:10:30.439 --> 1:10:32.960
<v Speaker 6>cosmology and just looking at the way that particle physicists

1:10:32.960 --> 1:10:36.040
<v Speaker 6>and cosmology have collaborated to really like, you know, why

1:10:36.040 --> 1:10:38.000
<v Speaker 6>do we understand the mechanisms of like the Big Bang

1:10:38.080 --> 1:10:38.679
<v Speaker 6>so well, it's.

1:10:38.520 --> 1:10:40.160
<v Speaker 8>Because we build particle accelerators.

1:10:41.240 --> 1:10:43.840
<v Speaker 6>And so I think without an experimental paradigm for these

1:10:43.920 --> 1:10:47.360
<v Speaker 6>questions that really ties the planetary and the alien search

1:10:47.439 --> 1:10:49.639
<v Speaker 6>to the original life, you have to couple those problems

1:10:49.680 --> 1:10:52.200
<v Speaker 6>through the same problem at their core. And I also

1:10:52.280 --> 1:10:54.280
<v Speaker 6>just like the radical idea that like alien life will

1:10:54.280 --> 1:10:56.320
<v Speaker 6>discover it on Earth and an experiment.

1:10:56.360 --> 1:10:59.320
<v Speaker 8>Because it's fine, but then we'll know what we're looking for.

1:10:59.439 --> 1:11:02.240
<v Speaker 6>So it was more obvious we can find it elsewhere, right, So,

1:11:02.680 --> 1:11:04.679
<v Speaker 6>like to me, that just seems logical, but it's also

1:11:04.720 --> 1:11:06.640
<v Speaker 6>fun because you know, like, it means we can do

1:11:06.640 --> 1:11:09.120
<v Speaker 6>the science really rapidly, and I want to see it solved,

1:11:09.160 --> 1:11:12.000
<v Speaker 6>so I want the most efficient route to an answer.

1:11:11.680 --> 1:11:13.439
<v Speaker 1>And then we'll have to argue about whether it's really

1:11:13.479 --> 1:11:15.439
<v Speaker 1>alien if it was on Earth after all.

1:11:15.600 --> 1:11:19.200
<v Speaker 6>Right, that's a good problem to have, right, because yeah,

1:11:19.280 --> 1:11:20.280
<v Speaker 6>a really good problem to.

1:11:20.240 --> 1:11:22.640
<v Speaker 3>Have come full circle to good beer conversations.

1:11:22.720 --> 1:11:24.559
<v Speaker 8>Yes, yes, there you go.

1:11:24.640 --> 1:11:26.400
<v Speaker 6>See if you answer one of the beer questions, but

1:11:26.479 --> 1:11:28.120
<v Speaker 6>you have a better beer question, it's not a problem.

1:11:29.880 --> 1:11:30.080
<v Speaker 3>Yep.

1:11:30.200 --> 1:11:31.960
<v Speaker 1>Well, thank you very much for coming on and talk

1:11:32.000 --> 1:11:34.920
<v Speaker 1>to us about assembly theory and for giving us an

1:11:34.960 --> 1:11:38.200
<v Speaker 1>advanced peak at your book. Everyone, it's called Life As

1:11:38.439 --> 1:11:42.200
<v Speaker 1>No One Knows It, the physics of Life's emergence. Congratulations

1:11:42.240 --> 1:11:43.479
<v Speaker 1>on the book and best of luck.

1:11:43.800 --> 1:11:45.840
<v Speaker 8>Thank you so much, Thank you both.

1:11:46.120 --> 1:11:46.720
<v Speaker 3>Yeah, thank you.

1:11:47.920 --> 1:11:49.880
<v Speaker 1>All right, and that was our conversation with Sarah and

1:11:49.920 --> 1:11:52.800
<v Speaker 1>Maria Walker, author of the recent book Life As No

1:11:52.840 --> 1:11:54.680
<v Speaker 1>One Knows it, which you can now pick up at

1:11:54.720 --> 1:11:58.479
<v Speaker 1>all fine booksellers. Kelly, what's your takeaway is physics is

1:11:58.479 --> 1:11:59.960
<v Speaker 1>going to help us understand what life is.

1:12:00.720 --> 1:12:04.000
<v Speaker 5>Well, you know, my takeaway is pretty similar to my

1:12:04.080 --> 1:12:06.760
<v Speaker 5>takeaway many years ago when I was arguing with my

1:12:06.800 --> 1:12:10.679
<v Speaker 5>fellow grad students, which is, Wow, this is complicated, which

1:12:10.720 --> 1:12:13.679
<v Speaker 5>is pretty much the conclusion to every ecology paper you'll

1:12:13.680 --> 1:12:17.599
<v Speaker 5>ever read is it's complicated and it depends and anyway.

1:12:17.680 --> 1:12:19.760
<v Speaker 5>So yeah, it's complicated.

1:12:19.560 --> 1:12:20.400
<v Speaker 3>What do you think.

1:12:20.560 --> 1:12:23.240
<v Speaker 1>I think it's a valiant effort and it's worth doing,

1:12:23.360 --> 1:12:25.960
<v Speaker 1>and we're going to learn things along the way. I

1:12:26.080 --> 1:12:28.519
<v Speaker 1>don't know that we're going to figure it out. I

1:12:28.560 --> 1:12:30.880
<v Speaker 1>don't know that this is the right approach, but I

1:12:30.880 --> 1:12:33.439
<v Speaker 1>think thinking hard about it is the first step to

1:12:33.439 --> 1:12:36.640
<v Speaker 1>figuring it out. No matter where it goes. Often you

1:12:36.720 --> 1:12:38.559
<v Speaker 1>go down to the root of something and you discover

1:12:38.600 --> 1:12:41.280
<v Speaker 1>something completely different than solving the problem you meant to,

1:12:42.000 --> 1:12:45.639
<v Speaker 1>or you make breakthroughs in other areas. So I'm excited

1:12:45.680 --> 1:12:47.720
<v Speaker 1>to see where this goes. I'm excited that people are

1:12:47.760 --> 1:12:50.840
<v Speaker 1>thinking about these problems. I think it helps clear away

1:12:50.840 --> 1:12:53.160
<v Speaker 1>some of the cobwebs and provides a little bit of clarity,

1:12:53.520 --> 1:12:54.880
<v Speaker 1>But I guess I have to put it into like

1:12:55.080 --> 1:12:58.120
<v Speaker 1>we'll see category before I'm actually convinced that this is

1:12:58.200 --> 1:13:00.040
<v Speaker 1>the right way to think about life.

1:13:00.120 --> 1:13:03.719
<v Speaker 5>I mean, it would be pretty epic if like on demand,

1:13:04.000 --> 1:13:05.720
<v Speaker 5>new life could be created in the lab and we

1:13:05.720 --> 1:13:08.360
<v Speaker 5>could look at different evolutionary trajectories and stuff like that.

1:13:08.439 --> 1:13:10.720
<v Speaker 5>I mean, the evolutionary biologists would go wild if that.

1:13:10.720 --> 1:13:11.520
<v Speaker 3>Could be accomplished.

1:13:11.600 --> 1:13:14.400
<v Speaker 5>I don't know where you start to do something like that,

1:13:14.880 --> 1:13:17.040
<v Speaker 5>but it would be pretty exciting if it could be accomplished.

1:13:17.360 --> 1:13:20.160
<v Speaker 1>Yeah. And then, of course, the next philosophical question would

1:13:20.200 --> 1:13:23.040
<v Speaker 1>be if you've created a new kind of living goo

1:13:23.240 --> 1:13:25.840
<v Speaker 1>in your lab, is it an alien or is it

1:13:25.880 --> 1:13:26.920
<v Speaker 1>just another kind of earthling?

1:13:27.160 --> 1:13:29.799
<v Speaker 3>And how long before it begins to eat human flesh?

1:13:32.120 --> 1:13:34.760
<v Speaker 1>Day one? I'm hoping. I mean, if this movie's going

1:13:34.800 --> 1:13:37.040
<v Speaker 1>to be any good, right, yeah.

1:13:36.960 --> 1:13:38.080
<v Speaker 3>No, it's going to happen fast.

1:13:38.880 --> 1:13:39.080
<v Speaker 8>Yeah.

1:13:39.720 --> 1:13:41.640
<v Speaker 1>I mean you could also flip the question around and

1:13:41.720 --> 1:13:43.920
<v Speaker 1>like say that new kind of living goo becomes intelligent,

1:13:44.000 --> 1:13:45.920
<v Speaker 1>how do we know it doesn't call us aliens?

1:13:46.000 --> 1:13:46.160
<v Speaker 6>Right?

1:13:46.200 --> 1:13:48.440
<v Speaker 1>And like we're at home, how can we be aliens?

1:13:48.760 --> 1:13:51.320
<v Speaker 5>That's right, that's right, let's all just get along and

1:13:51.360 --> 1:13:52.000
<v Speaker 5>be Earthlakes.

1:13:52.040 --> 1:13:52.639
<v Speaker 8>Am I right?

1:13:53.479 --> 1:13:56.360
<v Speaker 1>That sounds good exactly. I look forward to a big,

1:13:56.439 --> 1:13:59.400
<v Speaker 1>cozy family meal, passing the bread and the corn cobs

1:13:59.400 --> 1:14:01.519
<v Speaker 1>around with our fellow Earth new.

1:14:01.560 --> 1:14:03.920
<v Speaker 5>I'm going to schedule it one week after our meeting

1:14:04.000 --> 1:14:06.000
<v Speaker 5>where you tell me about how physics have solved all

1:14:06.040 --> 1:14:06.840
<v Speaker 5>the problems.

1:14:06.479 --> 1:14:06.920
<v Speaker 4>Of the world.

1:14:07.360 --> 1:14:09.080
<v Speaker 1>Sounds good, and I'll bring some towels.

1:14:09.760 --> 1:14:10.960
<v Speaker 3>That's good because I'll forget mine.

1:14:10.960 --> 1:14:14.320
<v Speaker 1>Bring extra, please, Katriina, We'll have an extra win in

1:14:14.360 --> 1:14:17.400
<v Speaker 1>her bag. No worries, all right. Thanks everyone for joining

1:14:17.439 --> 1:14:20.519
<v Speaker 1>us on this squishy discussion about the physics of life.

1:14:20.560 --> 1:14:22.760
<v Speaker 1>Hope you learned something I certainly did. And thank you

1:14:22.840 --> 1:14:25.880
<v Speaker 1>very much Kelly, my friend and co host, for joining

1:14:25.880 --> 1:14:27.080
<v Speaker 1>me on today's episode.

1:14:27.320 --> 1:14:28.839
<v Speaker 3>My pleasure. Thanks Daniel.

1:14:30.280 --> 1:14:37.800
<v Speaker 1>Tune in next time for more science and curiosity. Come

1:14:37.840 --> 1:14:40.640
<v Speaker 1>find us on social media where we answer questions and

1:14:40.800 --> 1:14:44.960
<v Speaker 1>post videos. We're on Twitter, Discorg, Instant, and now TikTok.

1:14:45.680 --> 1:14:48.479
<v Speaker 1>Thanks for listening, and remember that Daniel and Jorge Explain

1:14:48.520 --> 1:14:52.560
<v Speaker 1>the Universe is a production of iHeartRadio. For more podcasts

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