1 00:00:00,960 --> 00:00:03,200 Speaker 1: Hey, everybody, we are so glad to be coming back 2 00:00:03,279 --> 00:00:06,000 Speaker 1: to s F Sketch Fest this week, the best comedy 3 00:00:06,000 --> 00:00:08,280 Speaker 1: festival in the land, for our first live show in 4 00:00:08,280 --> 00:00:11,120 Speaker 1: two years. Yep, we're gonna be there on Friday, January 5 00:00:11,160 --> 00:00:14,640 Speaker 1: twenty one, seven thirty pm at the Sydney Goldstein Theater 6 00:00:14,720 --> 00:00:17,320 Speaker 1: to be specific. And if you want tickets then head 7 00:00:17,360 --> 00:00:19,840 Speaker 1: on over to s F Sketch Fest dot com or 8 00:00:19,880 --> 00:00:22,480 Speaker 1: City box Office dot com and search stuff you should know. 9 00:00:22,960 --> 00:00:25,880 Speaker 1: That's right. It's a vaccinated only show and a masking 10 00:00:25,960 --> 00:00:28,319 Speaker 1: up show, so everyone be safe, get out there and 11 00:00:28,320 --> 00:00:31,560 Speaker 1: come check us out live. We'll see you on January one. 12 00:00:33,400 --> 00:00:36,199 Speaker 1: Welcome to Stuff you Should Know, a production of I 13 00:00:36,280 --> 00:00:45,520 Speaker 1: Heart Radio. Hey, and welcome to the podcast. I'm Josh Clark, 14 00:00:45,560 --> 00:00:48,559 Speaker 1: and there's Charles w Chuck Bryan over there, and uh, 15 00:00:48,640 --> 00:00:52,720 Speaker 1: Jerry was just here. She said peace out, suckers, and 16 00:00:52,840 --> 00:00:55,640 Speaker 1: this is stuff you should know. Of course, it was 17 00:00:55,720 --> 00:01:00,680 Speaker 1: nice of her to log on to say goodbye. Right now, 18 00:01:00,680 --> 00:01:04,160 Speaker 1: we're just getting Jerry. She's been busy lately. Yeah, what happens. 19 00:01:04,640 --> 00:01:07,640 Speaker 1: It totally happens in this busy, go go world of 20 00:01:09,080 --> 00:01:14,160 Speaker 1: almost two The Double Deuce this year has just flown by. 21 00:01:14,920 --> 00:01:19,040 Speaker 1: It really has I think mercifully because this is going 22 00:01:19,080 --> 00:01:22,520 Speaker 1: to be part of the lost years when we look back, 23 00:01:22,760 --> 00:01:27,760 Speaker 1: you know. Yeah, it felt like eighteen years and somehow 24 00:01:28,600 --> 00:01:31,000 Speaker 1: one has just like been in a snap. Yeah. I 25 00:01:31,040 --> 00:01:35,160 Speaker 1: don't know what's going on. I don't think anyone does anymore, Chuck, 26 00:01:35,240 --> 00:01:37,960 Speaker 1: So don't don't feel bad. Uh. Can we shout out 27 00:01:38,000 --> 00:01:42,240 Speaker 1: to the people and sources that helped us along for 28 00:01:42,280 --> 00:01:47,920 Speaker 1: this one? Well, our buddy Dave Rouse wrote an article 29 00:01:48,040 --> 00:01:52,560 Speaker 1: for our Stuff Works. Uh, And I found a great 30 00:01:52,640 --> 00:01:55,040 Speaker 1: article from Wired. I forgot how much I love Wired. 31 00:01:55,120 --> 00:01:59,080 Speaker 1: That's from Mallory Pickett and BBC News, ABC News, NPR 32 00:01:59,200 --> 00:02:02,000 Speaker 1: Morning a Dish, which is always a fun listen. Uh, 33 00:02:02,160 --> 00:02:04,920 Speaker 1: National Library of Medicine here in the US. And then, 34 00:02:05,080 --> 00:02:07,559 Speaker 1: as always, I feel like it makes appearance in every 35 00:02:07,560 --> 00:02:13,519 Speaker 1: episode Jamaica Hospital dot Org. That's right, surprisingly helpful? Yeah, 36 00:02:13,600 --> 00:02:17,239 Speaker 1: maybe not surprisingly? I wonder is that Jamaica Queens or 37 00:02:17,320 --> 00:02:21,440 Speaker 1: Jamaica Jamaica. Oh you know what I was thinking, Jamaica Jamaica. 38 00:02:21,480 --> 00:02:25,800 Speaker 1: Maybe Jamaica Queens. Yeah, should I Jamaica scene Jamaica Queens. 39 00:02:26,400 --> 00:02:30,360 Speaker 1: My neighbor across the street, neighbor has uh is from Jamaica, 40 00:02:30,440 --> 00:02:33,280 Speaker 1: the country, and I feel like a heel now because 41 00:02:33,320 --> 00:02:38,000 Speaker 1: I was like, hey, that hospital websites great. Pat, She's like, 42 00:02:38,040 --> 00:02:41,360 Speaker 1: what are you talking about? She's like, okay, great, glad 43 00:02:41,440 --> 00:02:46,959 Speaker 1: you like some rando hospital website. Oh boys, so we're 44 00:02:47,000 --> 00:02:50,079 Speaker 1: talking today. You went and found some medical stuff. That's 45 00:02:50,080 --> 00:02:52,440 Speaker 1: why you went to look at Jamaica Hospital dot org. 46 00:02:52,480 --> 00:02:57,520 Speaker 1: I'm guessing because we're talking about a really interesting condition 47 00:02:57,560 --> 00:03:01,560 Speaker 1: and actually a few kinds of conditions that have something 48 00:03:02,480 --> 00:03:04,960 Speaker 1: unusual in common, and that is that the people who 49 00:03:05,000 --> 00:03:10,600 Speaker 1: suffer from these conditions have blue skin. Blueskin. You heard 50 00:03:10,600 --> 00:03:14,079 Speaker 1: it here first, everybody, even though this really first started 51 00:03:14,160 --> 00:03:17,000 Speaker 1: hitting the presses in two thousand eight. Yeah, I mean 52 00:03:17,000 --> 00:03:19,200 Speaker 1: you didn't hear it here first. This, I mean, this 53 00:03:19,280 --> 00:03:22,800 Speaker 1: is all over the internet. But we're talking about not 54 00:03:22,880 --> 00:03:26,880 Speaker 1: the Blue Man Group, but the Blue People Group of Kentucky. 55 00:03:27,680 --> 00:03:30,160 Speaker 1: It's a family that is I guess it's pronounced few Gate. 56 00:03:31,320 --> 00:03:35,840 Speaker 1: It's not. No, that's Italian. He was from France. Well 57 00:03:35,880 --> 00:03:39,160 Speaker 1: that's that's a spoiler. Oh is it? I'm sorry? I 58 00:03:39,200 --> 00:03:42,600 Speaker 1: take it back. Everyone. You know it's not a spoiler. 59 00:03:42,640 --> 00:03:45,440 Speaker 1: But for some reason, when I saw that the original 60 00:03:46,080 --> 00:03:50,200 Speaker 1: Martin Fugate was from France. From uh, I'm not sure 61 00:03:50,200 --> 00:03:52,400 Speaker 1: what part of France, but I was like, that's surprising. 62 00:03:52,560 --> 00:03:55,960 Speaker 1: It was like, I don't know why it would be. Uh. Yeah. 63 00:03:56,040 --> 00:03:57,840 Speaker 1: He could have come from anywhere in the world, and 64 00:03:57,880 --> 00:04:01,880 Speaker 1: he would have been like a completely overlookable person, I think, 65 00:04:02,000 --> 00:04:05,880 Speaker 1: totally lost to history had it not been for the 66 00:04:06,000 --> 00:04:10,840 Speaker 1: rare um rare genetic mutation that he happened to carry 67 00:04:10,880 --> 00:04:13,520 Speaker 1: with him. And even that wouldn't have gotten him into 68 00:04:13,520 --> 00:04:17,920 Speaker 1: the history books, Chuck, Even that wouldn't have. Instead, it 69 00:04:17,920 --> 00:04:23,200 Speaker 1: took Martin Fugate to happen, upon against all odds, to 70 00:04:23,560 --> 00:04:26,400 Speaker 1: have found a wife who he was not related to, 71 00:04:26,440 --> 00:04:29,679 Speaker 1: who was a total stranger from a totally different country, 72 00:04:29,920 --> 00:04:34,320 Speaker 1: who also happened to have that same rare genetic mutation. 73 00:04:34,400 --> 00:04:38,080 Speaker 1: And when the two get together, capal blue kids start 74 00:04:38,160 --> 00:04:42,680 Speaker 1: popping out. That's right. He came over from France to Kentucky, 75 00:04:42,720 --> 00:04:45,480 Speaker 1: to the Blue Hills of Kentucky. Ironically, Oh wow, I 76 00:04:45,480 --> 00:04:49,600 Speaker 1: hadn't thought about that. In And like I said, he 77 00:04:49,640 --> 00:04:51,320 Speaker 1: was from France when he was an orphan, so he 78 00:04:51,360 --> 00:04:53,760 Speaker 1: didn't know a lot about his his family as far 79 00:04:53,839 --> 00:04:56,559 Speaker 1: as uh, whether or not any of them were blue, 80 00:04:56,720 --> 00:04:59,640 Speaker 1: I guess, or if so, he wasn't he wasn't piping 81 00:04:59,720 --> 00:05:02,960 Speaker 1: up a out. Yeah, maybe he just kept it quiet. 82 00:05:03,680 --> 00:05:07,600 Speaker 1: But he did marry a redheaded American named Elizabeth Smith, 83 00:05:08,080 --> 00:05:11,240 Speaker 1: and they headed on over to Troublesome Creek near Hazard 84 00:05:11,240 --> 00:05:14,039 Speaker 1: County in Kentucky and set up a homestead there. And 85 00:05:14,240 --> 00:05:17,120 Speaker 1: it is a I mean the one of the doctors 86 00:05:17,160 --> 00:05:20,200 Speaker 1: that uh from one of these articles said, you know, 87 00:05:20,240 --> 00:05:23,440 Speaker 1: it's maybe one and a one hundred thousand chance that 88 00:05:23,480 --> 00:05:26,760 Speaker 1: you have to even have this genetic mutation. And he said, 89 00:05:26,760 --> 00:05:30,039 Speaker 1: but you know, once you start, I guess there's no 90 00:05:30,080 --> 00:05:32,560 Speaker 1: other way to say it. Once you start in breeding, 91 00:05:33,680 --> 00:05:38,159 Speaker 1: which can happen in the eighteen hundreds in the rural 92 00:05:38,200 --> 00:05:40,680 Speaker 1: nous of Kentucky, he said, that can go down all 93 00:05:40,680 --> 00:05:43,000 Speaker 1: the way to like one in eight chance. And that's 94 00:05:43,000 --> 00:05:45,600 Speaker 1: exactly what happened. Yeah, I was surprised there was even 95 00:05:45,640 --> 00:05:49,640 Speaker 1: one in eight. But there's some little fluke of genetics that, um, 96 00:05:49,720 --> 00:05:53,280 Speaker 1: that you have to when you're talking about probability in genetics, 97 00:05:53,279 --> 00:05:58,200 Speaker 1: it's a little more difficult than half in a straight math. Yeah. Um. 98 00:05:58,680 --> 00:06:03,680 Speaker 1: So apparently Martin himself possibly had like a little bit 99 00:06:03,680 --> 00:06:07,440 Speaker 1: of blue to him. His wife Elizabeth had no blue 100 00:06:07,480 --> 00:06:10,960 Speaker 1: to her um. She apparently had very very pale skin 101 00:06:11,040 --> 00:06:14,159 Speaker 1: and bright red hair. But when um the two got 102 00:06:14,160 --> 00:06:19,440 Speaker 1: together and those two genetic mutations donated UM their mutations 103 00:06:19,440 --> 00:06:22,720 Speaker 1: to that specific gene, they the kids that they had 104 00:06:22,839 --> 00:06:28,000 Speaker 1: were like, um, irresistibly blue. Like there was no confusing. 105 00:06:28,000 --> 00:06:30,479 Speaker 1: It's not like, yeah, Martin's kind of blue. If you 106 00:06:30,480 --> 00:06:34,160 Speaker 1: ever noticed, maybe you need to breathe more deeply. This 107 00:06:34,320 --> 00:06:38,040 Speaker 1: was like straight up blue kids. I've even seen him 108 00:06:38,080 --> 00:06:41,400 Speaker 1: described as dark blue, not even a bluish hue or 109 00:06:41,480 --> 00:06:46,000 Speaker 1: tint or tinge dark blue skinned children. Yea, four of 110 00:06:46,160 --> 00:06:49,240 Speaker 1: seven were blue. Uh. And it's funny he said that 111 00:06:49,279 --> 00:06:52,919 Speaker 1: she was not. The mother was not blue tinted. But 112 00:06:53,240 --> 00:06:58,000 Speaker 1: I imagine, like before they knew about genetics and in breeding, 113 00:06:58,880 --> 00:07:00,720 Speaker 1: if he would, if she would been a little blue, 114 00:07:00,760 --> 00:07:03,839 Speaker 1: that might have been a reason to get together, you 115 00:07:03,880 --> 00:07:07,880 Speaker 1: know what I mean? No, I don't explain. Well, blue 116 00:07:07,920 --> 00:07:10,920 Speaker 1: man happens to meet blue woman and they're like, jeez, 117 00:07:11,000 --> 00:07:14,160 Speaker 1: there's another one like me, and you know we've been 118 00:07:14,240 --> 00:07:16,760 Speaker 1: sort of you know, sort of embarrassing and maybe we're 119 00:07:16,800 --> 00:07:19,760 Speaker 1: cast out a little bit. So let's hitch our wagons 120 00:07:19,760 --> 00:07:23,960 Speaker 1: together because there's probably nothing wrong with us having kids, right, 121 00:07:25,000 --> 00:07:27,680 Speaker 1: His medical science hadn't known that at that point. It's 122 00:07:27,720 --> 00:07:30,400 Speaker 1: a story as old as time, Chuck, but it was. 123 00:07:32,000 --> 00:07:35,920 Speaker 1: It was just complete happenstance though, right. Yeah, So, UM, 124 00:07:35,920 --> 00:07:38,440 Speaker 1: And I wonder also, like it was significant to me 125 00:07:38,520 --> 00:07:42,320 Speaker 1: that they pointed out that his wife, Elizabeth Smith um 126 00:07:42,480 --> 00:07:45,680 Speaker 1: few Gates skin was almost translucent. It was so pale, 127 00:07:46,000 --> 00:07:50,520 Speaker 1: because I wonder if she donated that to her children, UM, 128 00:07:50,560 --> 00:07:53,080 Speaker 1: which allowed the blue to really shine through even more. 129 00:07:53,960 --> 00:07:58,440 Speaker 1: Maybe it's possible, like the ultimate recipe for blueness exactly. Um. 130 00:07:58,520 --> 00:08:01,480 Speaker 1: And they actually became owns, this blue family, and they 131 00:08:01,480 --> 00:08:05,240 Speaker 1: were not particularly proud of their blue skin. I think 132 00:08:05,240 --> 00:08:07,160 Speaker 1: they were a little freaked out about it. I think 133 00:08:07,160 --> 00:08:10,360 Speaker 1: that their neighbors may not have particularly treated them well, 134 00:08:10,440 --> 00:08:13,640 Speaker 1: and so they already lived in like a pretty isolated 135 00:08:13,720 --> 00:08:17,480 Speaker 1: part of Appalachia, UM, but they took pains to actually 136 00:08:17,480 --> 00:08:20,640 Speaker 1: isolate themselves even further. And one of the one of 137 00:08:20,680 --> 00:08:24,440 Speaker 1: the consequences of that was something you touched upon. That 138 00:08:24,440 --> 00:08:28,200 Speaker 1: that meant that, Um, their son married their aunt, and 139 00:08:28,320 --> 00:08:31,400 Speaker 1: cousins married cousins, even if they were way too close 140 00:08:31,440 --> 00:08:34,320 Speaker 1: to be marrying, and so one of the one of 141 00:08:34,360 --> 00:08:38,600 Speaker 1: the products of these this inner marriage was an entire 142 00:08:39,440 --> 00:08:43,240 Speaker 1: small regional population of blue families or families who have 143 00:08:43,360 --> 00:08:47,880 Speaker 1: blue children or Blue family members, because these neighbor families 144 00:08:48,120 --> 00:08:51,880 Speaker 1: were still blood relatives of the few Gates who initially 145 00:08:52,240 --> 00:08:57,280 Speaker 1: settled this area and just started reproducing through inbreeding. Uh. 146 00:08:57,320 --> 00:09:00,200 Speaker 1: And the condition that they had is not a skin 147 00:09:00,240 --> 00:09:02,880 Speaker 1: condition at all. It's actually a blood disorder like you mentioned, 148 00:09:03,240 --> 00:09:08,600 Speaker 1: and it's called medima globinemia. It's so pretty good. Wow, 149 00:09:09,000 --> 00:09:12,959 Speaker 1: you're so it's not meth now, Okay, Oh, I'm glad 150 00:09:13,000 --> 00:09:16,600 Speaker 1: you said it first. Then I actually took great pains 151 00:09:16,600 --> 00:09:19,040 Speaker 1: today to look up between this and the other episode 152 00:09:19,080 --> 00:09:25,640 Speaker 1: we're recording pronunciations, and when you look at medima globinemia, 153 00:09:25,880 --> 00:09:29,559 Speaker 1: that is seventeen letters of it's a mouthful of letters, 154 00:09:30,040 --> 00:09:33,080 Speaker 1: pure hell. And it's really one of those that I 155 00:09:33,120 --> 00:09:35,000 Speaker 1: looked at over and over and just could not get 156 00:09:35,000 --> 00:09:36,800 Speaker 1: it right in my head until I, you know, went 157 00:09:36,840 --> 00:09:38,240 Speaker 1: and looked it up on the internet and I was like, 158 00:09:38,480 --> 00:09:39,960 Speaker 1: that's not so hard, all right, let me try. Let 159 00:09:40,000 --> 00:09:44,080 Speaker 1: me try mediema globinemia. I think it's more of a 160 00:09:44,120 --> 00:09:47,800 Speaker 1: t than a d uh, okay, what about a t 161 00:09:49,240 --> 00:09:53,320 Speaker 1: you want me try that one? This is like the 162 00:09:53,400 --> 00:10:01,520 Speaker 1: worst acting audition ever. What's my motivation here? Uh to 163 00:10:01,559 --> 00:10:05,120 Speaker 1: get through this episode? Uh So we're gonna touch a 164 00:10:05,120 --> 00:10:08,720 Speaker 1: little bit on melanin throughout this episode. But you remember 165 00:10:08,760 --> 00:10:13,160 Speaker 1: melanin from our I think pretty good episode on sunscreen 166 00:10:13,320 --> 00:10:18,200 Speaker 1: and sun tans, right. Uh? And this is uh, you know, 167 00:10:18,240 --> 00:10:21,280 Speaker 1: special cells in the body, in the skin make melanin 168 00:10:21,760 --> 00:10:24,640 Speaker 1: and they are Melanin is responsible for coloring your skin. 169 00:10:25,360 --> 00:10:28,840 Speaker 1: And there are all kinds of different uh melanin disorders, 170 00:10:28,880 --> 00:10:31,640 Speaker 1: whether you have too much or too little, whether you 171 00:10:31,679 --> 00:10:33,840 Speaker 1: can you know, we'll make your skin lighter or darker, 172 00:10:34,600 --> 00:10:37,679 Speaker 1: or whether or not it happens in patches. I had 173 00:10:37,679 --> 00:10:41,959 Speaker 1: a friend in Los Angeles with bid eligo, which oh 174 00:10:42,000 --> 00:10:46,080 Speaker 1: you do, which you know leads to uh, patches of 175 00:10:46,160 --> 00:10:49,160 Speaker 1: light skin on the body. In't that what Michael Jackson 176 00:10:49,160 --> 00:10:53,600 Speaker 1: claimed to have had to Yes? Was that verified? I 177 00:10:53,679 --> 00:10:56,520 Speaker 1: don't know. I don't know either. I really don't know, 178 00:10:56,559 --> 00:10:58,280 Speaker 1: because I just remember there was a big stink when 179 00:10:58,320 --> 00:11:00,320 Speaker 1: that came out and everyone was like, yeah, right, the 180 00:11:00,480 --> 00:11:03,520 Speaker 1: well the reason why it was like, really it's you 181 00:11:03,600 --> 00:11:07,600 Speaker 1: got videlago because it's usually um patches like the melano sites. 182 00:11:07,600 --> 00:11:10,360 Speaker 1: The melanin producing cells just kind of poop out or 183 00:11:10,360 --> 00:11:14,040 Speaker 1: crap out in an area, and it it leaves like 184 00:11:14,120 --> 00:11:18,679 Speaker 1: patches without pigment, not your entire face, um without pigment. 185 00:11:18,800 --> 00:11:21,679 Speaker 1: But who knows, well, I think his I think what 186 00:11:21,720 --> 00:11:24,800 Speaker 1: he said was that he bleached his skin to match 187 00:11:24,840 --> 00:11:28,760 Speaker 1: the light patches. Was his reasoning. Oh, well, that's fairly reasonable. 188 00:11:29,080 --> 00:11:32,400 Speaker 1: You know, if you're self conscious about videlago and you 189 00:11:32,440 --> 00:11:34,920 Speaker 1: have a ton of money, you could do something like that. 190 00:11:35,440 --> 00:11:39,280 Speaker 1: Who knows, Who knows? Should we talk about skin color? 191 00:11:39,360 --> 00:11:42,480 Speaker 1: Should we take an awkward Michael Jackson break? I think 192 00:11:42,520 --> 00:11:44,880 Speaker 1: we just did. But the point is this that I 193 00:11:44,920 --> 00:11:48,480 Speaker 1: think you're making, Chuck, is that changes in like your 194 00:11:48,520 --> 00:11:51,800 Speaker 1: skin color typically have to do with a lack of 195 00:11:52,040 --> 00:11:56,000 Speaker 1: or an overproduction of melanin. Right, And that what we're 196 00:11:56,040 --> 00:12:02,520 Speaker 1: talking about, uh, mattiemoglobinemia right, is actually a blood disorder. 197 00:12:02,600 --> 00:12:05,080 Speaker 1: It's not has nothing to do with the skin. It 198 00:12:05,240 --> 00:12:09,880 Speaker 1: just shines through that super translucent skin that we have. Right, 199 00:12:09,960 --> 00:12:14,559 Speaker 1: So what's going on here in the body? Okay, So 200 00:12:15,280 --> 00:12:18,880 Speaker 1: are you surprised, I'm asking you. I'm a little surprised. 201 00:12:19,080 --> 00:12:22,720 Speaker 1: I thought we maybe tagging team this one. But okay, okay, so, 202 00:12:23,000 --> 00:12:26,240 Speaker 1: uh you have like a pink is shoe too, typically 203 00:12:26,760 --> 00:12:31,760 Speaker 1: being being Caucasian. Um, because you're there's not a ton 204 00:12:31,760 --> 00:12:37,120 Speaker 1: of melonin that's blocking the blood supply underneath and your tissues. 205 00:12:37,160 --> 00:12:40,400 Speaker 1: It's kind of shining through and your blood is red. 206 00:12:40,480 --> 00:12:45,680 Speaker 1: And the reason it's red, Chuck, is because because the 207 00:12:45,760 --> 00:12:48,520 Speaker 1: reason why blood is red, well, remember in school they 208 00:12:48,520 --> 00:12:51,120 Speaker 1: teach you that your blood is blue until you get 209 00:12:51,120 --> 00:12:53,520 Speaker 1: cut and then it hits the air. Yeah, that's not true, 210 00:12:53,720 --> 00:12:55,120 Speaker 1: and then it turns red. That's what you hear on 211 00:12:55,160 --> 00:12:58,680 Speaker 1: the playground in elementary school from dumb kids. But that 212 00:12:58,840 --> 00:13:00,679 Speaker 1: is not true. And I bet you anything, kids are 213 00:13:00,679 --> 00:13:04,040 Speaker 1: still spreading that mistruth on the playground. Yeah. It's got 214 00:13:04,080 --> 00:13:06,839 Speaker 1: some staying power for sure, as far as as far 215 00:13:06,880 --> 00:13:09,600 Speaker 1: as rumors go. And you know what, my dad will 216 00:13:09,640 --> 00:13:13,600 Speaker 1: sue your dad for all the money he's got. Did 217 00:13:13,600 --> 00:13:18,559 Speaker 1: you guys threaten lawsuits? Sure? We were very lutitious kids 218 00:13:18,600 --> 00:13:20,360 Speaker 1: did though. It was very funny. We were like, we're 219 00:13:20,400 --> 00:13:24,520 Speaker 1: like little Puritans in in Salem town. That's right. Uh 220 00:13:24,600 --> 00:13:28,880 Speaker 1: so blood is red? That was a question, right? Uh? Yeah, yeah, 221 00:13:28,880 --> 00:13:31,920 Speaker 1: why is blood red, right, because I don't know we've 222 00:13:31,920 --> 00:13:34,840 Speaker 1: talked about this before, but it's because our red blood 223 00:13:34,880 --> 00:13:38,400 Speaker 1: cells have hemoglobe and it's a protein and it gets 224 00:13:38,480 --> 00:13:42,239 Speaker 1: its red color from something called hem It's a compound 225 00:13:42,280 --> 00:13:45,160 Speaker 1: that has an iron atom in there, and that iron 226 00:13:45,200 --> 00:13:48,079 Speaker 1: atom is the key. That's what binds with oxygen and 227 00:13:48,240 --> 00:13:51,560 Speaker 1: allows red blood cells to get oxygen all over the body, 228 00:13:52,200 --> 00:13:55,480 Speaker 1: and that's sort of what makes us tick. Yeah, it 229 00:13:55,559 --> 00:13:58,520 Speaker 1: definitely is. I mean that oxygen is super important, so 230 00:13:58,640 --> 00:14:02,480 Speaker 1: we want to have super red rich hemoglobin blood. Right. 231 00:14:03,120 --> 00:14:08,040 Speaker 1: Our bodies also produced something else called metemoglobin's I guess 232 00:14:08,120 --> 00:14:10,000 Speaker 1: is how you would pronounce it. That is not how 233 00:14:10,080 --> 00:14:13,000 Speaker 1: I've been pronouncing it in my head. But these metema 234 00:14:13,000 --> 00:14:17,320 Speaker 1: globins are basically the same thing as hemoglobins, but they 235 00:14:17,360 --> 00:14:20,040 Speaker 1: have a different kind of iron attached to them. The 236 00:14:20,080 --> 00:14:23,040 Speaker 1: iron they have is like, there's really another way to 237 00:14:23,040 --> 00:14:24,880 Speaker 1: put it. Actually, there's plenty of other ways to put it, 238 00:14:24,880 --> 00:14:26,920 Speaker 1: but one way you could put it is that is rusted. 239 00:14:27,360 --> 00:14:32,160 Speaker 1: It's oxidized iron, which means that it's missing an electron 240 00:14:32,640 --> 00:14:35,160 Speaker 1: that it would need to bind oxygen, which means it's 241 00:14:35,320 --> 00:14:38,760 Speaker 1: useless for transporting oxygen. Through the blood. So if you 242 00:14:38,760 --> 00:14:41,160 Speaker 1: have a bunch of metemoglobin built up in your blood, 243 00:14:41,200 --> 00:14:44,040 Speaker 1: your blood can reasonably turn blue. You also may have 244 00:14:44,080 --> 00:14:48,239 Speaker 1: some problems breathing um because you don't have any oxygen 245 00:14:48,280 --> 00:14:50,600 Speaker 1: in your blood, although that's not true, I'm sorry. You 246 00:14:50,640 --> 00:14:53,560 Speaker 1: would be able to breathe, breathe perfectly fine, but it 247 00:14:53,640 --> 00:14:58,000 Speaker 1: wouldn't clear up necessarily the lack of oxygen your blood 248 00:14:58,000 --> 00:15:01,080 Speaker 1: because it's on a blood level um rather than something 249 00:15:01,120 --> 00:15:04,160 Speaker 1: to do with your lungs. Yeah, that was my one question, 250 00:15:04,240 --> 00:15:09,480 Speaker 1: because doctor after doctor is confirmed that mativa globinemia doesn't 251 00:15:09,520 --> 00:15:13,040 Speaker 1: present any health issues. But how can that be possible 252 00:15:13,080 --> 00:15:17,120 Speaker 1: that your blood has is having trouble carrying oxygen to 253 00:15:17,200 --> 00:15:19,560 Speaker 1: your body and it doesn't matter. I had a really 254 00:15:19,560 --> 00:15:21,440 Speaker 1: hard time with that too. And the best I could 255 00:15:21,440 --> 00:15:24,000 Speaker 1: come up with as far as an answer, which is 256 00:15:24,040 --> 00:15:26,040 Speaker 1: not definitive, but the best that can come up with, 257 00:15:26,160 --> 00:15:29,720 Speaker 1: is that there is a there's a threshold where your 258 00:15:29,800 --> 00:15:33,480 Speaker 1: blood will turn blue, where you have enough metema globins 259 00:15:33,520 --> 00:15:37,600 Speaker 1: in there that it's blue, but not so there's not 260 00:15:37,680 --> 00:15:40,880 Speaker 1: so many metema globins that you're actually having trouble with 261 00:15:40,960 --> 00:15:44,400 Speaker 1: your oxygen in your body. So it can turn blue 262 00:15:44,440 --> 00:15:47,360 Speaker 1: long before you actually like suffer from the effects of 263 00:15:47,440 --> 00:15:52,080 Speaker 1: low oxygen um. Does that make sense? Yeah, I guess 264 00:15:52,080 --> 00:15:55,040 Speaker 1: that makes sense. And isn't the threshold to turn your 265 00:15:55,080 --> 00:15:58,320 Speaker 1: skin blue like a really low percentage, even like one 266 00:15:58,360 --> 00:16:00,880 Speaker 1: percent of metemaments. If you're blood is one percent in 267 00:16:00,920 --> 00:16:03,200 Speaker 1: team of globins, you can start to turn blue right 268 00:16:03,280 --> 00:16:06,360 Speaker 1: So it doesn't take very much, which means that you 269 00:16:06,360 --> 00:16:10,520 Speaker 1: have of of the global the globins in your blood 270 00:16:10,560 --> 00:16:14,360 Speaker 1: are are hemoglobin, which means you're still able to get 271 00:16:14,360 --> 00:16:16,880 Speaker 1: all the oxygen you need. You just have maybe a 272 00:16:16,920 --> 00:16:19,640 Speaker 1: little less than somebody else. That's my best guess from 273 00:16:19,680 --> 00:16:23,200 Speaker 1: what I saw UM, and I think at this point 274 00:16:23,200 --> 00:16:26,400 Speaker 1: in our understanding of my team of globalemia, it's as 275 00:16:26,440 --> 00:16:29,560 Speaker 1: good as anybody's. Well. That sounds like a perfect place 276 00:16:29,600 --> 00:16:32,600 Speaker 1: for a break, Okay, and uh, we'll be right back 277 00:16:32,640 --> 00:16:35,000 Speaker 1: to talk a little bit more about this and other 278 00:16:35,520 --> 00:16:58,680 Speaker 1: interesting blood conditions right for this, So, Chuck, where're talking 279 00:16:58,680 --> 00:17:02,800 Speaker 1: about my team globe and temia um and the reason like, 280 00:17:02,800 --> 00:17:04,679 Speaker 1: like I think one of us said earlier that the 281 00:17:04,720 --> 00:17:10,280 Speaker 1: body naturally produces these things, um, these metema globins um, 282 00:17:10,359 --> 00:17:14,720 Speaker 1: but we also produce an enzyme that can convert excess 283 00:17:14,760 --> 00:17:19,159 Speaker 1: metema globins into hemoglobin, and it's got a doozy of 284 00:17:19,160 --> 00:17:22,480 Speaker 1: a name which I just love. May I take this one? Yes, 285 00:17:23,720 --> 00:17:29,320 Speaker 1: this enzyme is called reduced nicotinamide adenine dionucleotide cytochrome B 286 00:17:29,520 --> 00:17:33,960 Speaker 1: five reduct as one of the great all times nicknames. 287 00:17:34,000 --> 00:17:35,800 Speaker 1: It has no nickname. You have to say the entire 288 00:17:35,880 --> 00:17:41,240 Speaker 1: thing every time. And so this enzyme, reduced nicotinamine ad 289 00:17:41,240 --> 00:17:44,840 Speaker 1: aine dionucleotide side of chrome B five reduct days is 290 00:17:44,840 --> 00:17:50,280 Speaker 1: actually capable of converting the iron from its um ferric 291 00:17:50,359 --> 00:17:54,720 Speaker 1: state in metema globin's into its fairest state, which is 292 00:17:55,000 --> 00:17:57,720 Speaker 1: capable of binding with oxygen like the kind that's found 293 00:17:57,760 --> 00:18:01,680 Speaker 1: in hemoglobin. So, for all intents and purposes, reduced nicotinamide 294 00:18:01,720 --> 00:18:06,480 Speaker 1: adenine dinucleotide cytochrome B five reductase is capable of converting 295 00:18:06,720 --> 00:18:10,399 Speaker 1: metemoglobins into hemoglobin. And most of us are able to 296 00:18:10,440 --> 00:18:13,320 Speaker 1: do that. But if you're like a few gate and 297 00:18:13,440 --> 00:18:17,080 Speaker 1: you have that rare genetic condition where both parents donated 298 00:18:17,119 --> 00:18:21,960 Speaker 1: that mutation to you and you developed metemoglobinemia, but there's 299 00:18:22,000 --> 00:18:27,320 Speaker 1: some reduced amount of reduced nicotinamide adenine dionucleotide cytochrome B 300 00:18:27,480 --> 00:18:32,000 Speaker 1: five reductas, which means that that metemoglobin's that you naturally 301 00:18:32,040 --> 00:18:35,280 Speaker 1: produced are able to build up and accumulate in your blood. 302 00:18:35,320 --> 00:18:37,520 Speaker 1: And when they do that, and they they they that's 303 00:18:37,520 --> 00:18:39,600 Speaker 1: how you start to turn blue. That's how you cross 304 00:18:39,680 --> 00:18:42,920 Speaker 1: that one percent threshold. That's right. And this is one 305 00:18:42,960 --> 00:18:46,119 Speaker 1: of the rare times where you can actually have a 306 00:18:46,160 --> 00:18:50,760 Speaker 1: genetic condition that's pretty easily solved. And in this case, 307 00:18:50,800 --> 00:18:53,240 Speaker 1: it's just a pill. Uh. And the guy who figured 308 00:18:53,280 --> 00:18:56,159 Speaker 1: this out has sort of an interesting story in his 309 00:18:56,200 --> 00:19:01,159 Speaker 1: own right. His name is Madison Coween or Coine Kaween. 310 00:19:01,600 --> 00:19:08,320 Speaker 1: I'm going with col Wayne cal Wine, Colween, c A 311 00:19:08,560 --> 00:19:13,359 Speaker 1: w Ei and Coween, although I like cow Wine. That 312 00:19:13,440 --> 00:19:15,639 Speaker 1: doesn't sound like you'd be tasty, but I'll beg it 313 00:19:15,640 --> 00:19:18,919 Speaker 1: gives you a pretty good bus. Uh. He was the 314 00:19:19,880 --> 00:19:22,879 Speaker 1: h He was the grandson of a pretty famous at 315 00:19:22,880 --> 00:19:26,679 Speaker 1: the time poet out of Kentucky. Uh. And Madison was 316 00:19:26,720 --> 00:19:30,679 Speaker 1: the third of of the Madison's. And this is just 317 00:19:30,720 --> 00:19:34,639 Speaker 1: a side note, very sad and interesting. His wife was 318 00:19:34,800 --> 00:19:39,000 Speaker 1: poisoned and murdered by poison in the nineteen sixties and 319 00:19:39,000 --> 00:19:41,520 Speaker 1: no one was ever caught in charge with a crime 320 00:19:41,520 --> 00:19:45,000 Speaker 1: and it kind of remains one of Kentucky's um, you know, 321 00:19:45,040 --> 00:19:47,440 Speaker 1: sort of biggest cold cases. Wow, I did not see 322 00:19:47,440 --> 00:19:50,639 Speaker 1: that one coming. Yeah, he and his wife and this 323 00:19:50,720 --> 00:19:53,359 Speaker 1: other couple were out drinking all night supposedly like just 324 00:19:53,400 --> 00:19:58,840 Speaker 1: got slashed and at a at a at a country club. Um. 325 00:19:58,960 --> 00:20:01,040 Speaker 1: He Madison didn't even make at home. I think he 326 00:20:01,119 --> 00:20:05,840 Speaker 1: stayed the night there, but the other man, the man 327 00:20:05,880 --> 00:20:09,680 Speaker 1: from the other couple, drove his wife home. Um, apparently 328 00:20:09,720 --> 00:20:12,240 Speaker 1: just dropped. They had another nightcap and she woke up dead. 329 00:20:12,280 --> 00:20:15,680 Speaker 1: One didn't wake up dead. She died and they thought 330 00:20:15,720 --> 00:20:18,680 Speaker 1: it was just you know, alcohol or some natural cause. 331 00:20:18,720 --> 00:20:20,639 Speaker 1: But then they found these two like little needle pricks 332 00:20:20,680 --> 00:20:25,359 Speaker 1: in her where they think she was I guess given 333 00:20:25,400 --> 00:20:28,040 Speaker 1: a shot to pass out and then poisoned. And I 334 00:20:28,040 --> 00:20:30,280 Speaker 1: can't remember the poison. It was some sort of like 335 00:20:30,640 --> 00:20:34,800 Speaker 1: acid or something. But yeah, really really interesting. Neither here 336 00:20:34,800 --> 00:20:36,960 Speaker 1: nor there as far as this goes. But that's the 337 00:20:37,000 --> 00:20:42,399 Speaker 1: sad story of Dr Madison. Uh cow wines wife. Was 338 00:20:42,440 --> 00:20:45,840 Speaker 1: he a suspect because I would have suspected him. I 339 00:20:45,880 --> 00:20:48,240 Speaker 1: don't think so, because he wasn't even there. That's the 340 00:20:48,240 --> 00:20:50,879 Speaker 1: first thing I thought but apparently it was pretty verified 341 00:20:50,920 --> 00:20:53,280 Speaker 1: that he slept it off at the country club. I 342 00:20:53,320 --> 00:20:56,239 Speaker 1: guess crazy because yeah, well, I mean one of the 343 00:20:56,280 --> 00:20:58,680 Speaker 1: things that he became famous for, if not the thing 344 00:20:58,720 --> 00:21:01,520 Speaker 1: he became famous for. It wasn't jacting people with with 345 00:21:01,880 --> 00:21:06,080 Speaker 1: some fairly weird stuff. I know, isn't that weird? It 346 00:21:06,240 --> 00:21:09,680 Speaker 1: is weird. You're not buying it. No, I don't want 347 00:21:09,680 --> 00:21:11,960 Speaker 1: to like cast persions on somebody. I don't know enough 348 00:21:12,000 --> 00:21:15,399 Speaker 1: about the story, but that's just very odd, especially like 349 00:21:15,920 --> 00:21:20,400 Speaker 1: judging from this ninety second story, exactly I can conclusively 350 00:21:20,480 --> 00:21:22,840 Speaker 1: solve this case. I've seen enough law in order to 351 00:21:22,920 --> 00:21:25,840 Speaker 1: know that the husband almost always did it else that 352 00:21:25,960 --> 00:21:28,280 Speaker 1: is probably true, but probably not in this case. But 353 00:21:28,480 --> 00:21:32,320 Speaker 1: at any rate, he was a hematologist at you at 354 00:21:32,440 --> 00:21:36,960 Speaker 1: the University of Kentucky, and he heard about these people 355 00:21:37,040 --> 00:21:39,879 Speaker 1: throughout the world and really wanted to kind of get 356 00:21:39,920 --> 00:21:42,440 Speaker 1: to the bottom of this. When a couple of them, 357 00:21:42,680 --> 00:21:44,480 Speaker 1: uh well, I don't think these were few gates, but 358 00:21:44,520 --> 00:21:47,920 Speaker 1: Patrick and Rachel Ritchie, I guess you know it happened 359 00:21:47,920 --> 00:21:50,880 Speaker 1: in some other family. Know the Combs is. We knew 360 00:21:50,880 --> 00:21:53,520 Speaker 1: it Combs from Kentucky. We had a friend that we 361 00:21:53,600 --> 00:21:56,840 Speaker 1: worked with for a little while. Really he was never 362 00:21:57,400 --> 00:22:00,399 Speaker 1: struck me as blue. Yeah, he never struck you. But 363 00:22:00,440 --> 00:22:02,320 Speaker 1: I wonder if he is related to the combs is, 364 00:22:03,720 --> 00:22:08,439 Speaker 1: which would make him vibe some somehow. Few Gate because again, 365 00:22:08,760 --> 00:22:11,040 Speaker 1: these these families in the few Gate area where all 366 00:22:11,080 --> 00:22:14,399 Speaker 1: if you went back far enough, few Gates exactly. All right, 367 00:22:14,440 --> 00:22:16,520 Speaker 1: So these people walk into his office and what happened? 368 00:22:16,800 --> 00:22:18,880 Speaker 1: So here here's the thing, Like, they didn't walk into 369 00:22:19,000 --> 00:22:21,239 Speaker 1: his office, he went and found them. I read an 370 00:22:21,359 --> 00:22:25,240 Speaker 1: article about him, and he became maybe a little obsessed 371 00:22:25,240 --> 00:22:27,960 Speaker 1: with finding these people. Wanted to know what the heck 372 00:22:28,040 --> 00:22:29,840 Speaker 1: was going on. So he actually went out in the 373 00:22:29,840 --> 00:22:33,000 Speaker 1: woods and would wait for them, and every once in 374 00:22:33,000 --> 00:22:34,920 Speaker 1: a while would see one and he chased them, telling 375 00:22:34,960 --> 00:22:36,800 Speaker 1: him to stop, and of course they would run off. 376 00:22:37,200 --> 00:22:39,000 Speaker 1: So he figured out another way to do it. He 377 00:22:39,040 --> 00:22:42,399 Speaker 1: moved to Hazard County near Troublesome Creek, and he started 378 00:22:42,440 --> 00:22:45,800 Speaker 1: asking around at clinics, like had anybody ever treated a 379 00:22:45,840 --> 00:22:50,639 Speaker 1: blue patient? And he finally struck gold Um blue Gold 380 00:22:50,840 --> 00:22:53,360 Speaker 1: when he spoke to one nurse at a clinic that said, yeah, 381 00:22:53,400 --> 00:22:55,199 Speaker 1: this this one woman came in with blue skin and 382 00:22:55,240 --> 00:22:57,400 Speaker 1: she was really self conscious about her skin. She came 383 00:22:57,440 --> 00:22:59,919 Speaker 1: to the back door. Was really just kind of me, 384 00:23:00,000 --> 00:23:03,520 Speaker 1: he can embarrassed. Um, but yeah, we've treated a blue 385 00:23:03,520 --> 00:23:07,600 Speaker 1: person before. So Colween basically hung around this clinic until 386 00:23:08,080 --> 00:23:10,240 Speaker 1: more blue people came in and that this is where 387 00:23:10,320 --> 00:23:14,639 Speaker 1: he met the Richie siblings. Yeah, so he started to 388 00:23:14,680 --> 00:23:17,280 Speaker 1: dig into their family a little bit. Uh. It became 389 00:23:17,320 --> 00:23:19,919 Speaker 1: pretty obvious to him that it was a genetic disorder, 390 00:23:20,600 --> 00:23:24,080 Speaker 1: and he started digging around other stories around the North 391 00:23:24,160 --> 00:23:28,280 Speaker 1: America and found an Inuit population in Alaska who had 392 00:23:29,560 --> 00:23:31,960 Speaker 1: who had the same condition. I'm just gonna call it 393 00:23:32,000 --> 00:23:34,919 Speaker 1: this condition now. I think we said it enough, at 394 00:23:35,000 --> 00:23:38,160 Speaker 1: least I have. And he said, well, you know these 395 00:23:38,160 --> 00:23:42,280 Speaker 1: people were interbreeding a lot because they were very remote 396 00:23:42,320 --> 00:23:45,120 Speaker 1: as well. And so he said, I think we understand 397 00:23:45,200 --> 00:23:49,280 Speaker 1: the problem here. How do we fix it? Yeah, I 398 00:23:49,320 --> 00:23:53,320 Speaker 1: don't know if he where he he got this idea, 399 00:23:54,000 --> 00:23:57,520 Speaker 1: but he used something called methylene blue, which was already 400 00:23:57,560 --> 00:24:01,639 Speaker 1: like in wide use. It's used to staying tissue because 401 00:24:01,680 --> 00:24:05,439 Speaker 1: it affects some cells differently than others. Um, it was 402 00:24:05,480 --> 00:24:13,159 Speaker 1: a malarial treatment, which malaria can actually produce matema globe anemia. 403 00:24:14,240 --> 00:24:17,480 Speaker 1: And suddenly having trouble saying, because we have been practicing lately. 404 00:24:18,080 --> 00:24:21,280 Speaker 1: Um And what it does is it goes in and 405 00:24:21,440 --> 00:24:27,200 Speaker 1: it interacts with the reduced nicotinamine, adenine di nucleotide side 406 00:24:27,280 --> 00:24:29,719 Speaker 1: chrome B five reductation and basically gives it a boost 407 00:24:30,080 --> 00:24:35,399 Speaker 1: and helps convert all of that excess um matema globins 408 00:24:35,400 --> 00:24:40,159 Speaker 1: into hemoglobins in patients with metema globe anemia. And so 409 00:24:40,320 --> 00:24:42,920 Speaker 1: I don't know where he got the idea, but he 410 00:24:43,040 --> 00:24:46,080 Speaker 1: tried it and apparently injected the Ritchie kids with it, 411 00:24:46,160 --> 00:24:50,800 Speaker 1: and they they stopped being blue, like almost on the spot. Yeah, 412 00:24:50,880 --> 00:24:54,760 Speaker 1: Like minutes later they returned to a to a you know, 413 00:24:54,920 --> 00:25:00,360 Speaker 1: a standard color, and I mean they were overjoyed. Could 414 00:25:00,359 --> 00:25:02,840 Speaker 1: you imagine being like this your whole life, getting a 415 00:25:02,880 --> 00:25:04,920 Speaker 1: shot and looking in the mirror a few minutes later 416 00:25:04,920 --> 00:25:07,080 Speaker 1: and you're like, oh my gosh, it's like it's it's gone. 417 00:25:07,160 --> 00:25:10,160 Speaker 1: It's actually really sweet because they were very self conscious, 418 00:25:10,160 --> 00:25:12,560 Speaker 1: the whole family. I mean, this family like retreated to 419 00:25:12,640 --> 00:25:15,679 Speaker 1: the woods to to like people didn't know where they lived, 420 00:25:15,960 --> 00:25:17,919 Speaker 1: and they lived like five miles away from him and 421 00:25:17,960 --> 00:25:20,439 Speaker 1: knew that there's this blue family still had no idea 422 00:25:20,480 --> 00:25:22,920 Speaker 1: where they lived. It was like that's how far they 423 00:25:22,960 --> 00:25:25,760 Speaker 1: retreated from society because they were that self conscious. So yeah, 424 00:25:25,960 --> 00:25:29,480 Speaker 1: I'm sure it's a pretty joyous occasion for them. There's 425 00:25:29,480 --> 00:25:31,199 Speaker 1: gonna be a movie about this at some point, right, 426 00:25:31,200 --> 00:25:33,600 Speaker 1: I can't believe there's not. There's a very famous interview 427 00:25:33,600 --> 00:25:36,840 Speaker 1: with Kyle Wayne in a magazine called Science Ad two. 428 00:25:37,160 --> 00:25:40,320 Speaker 1: And there's also a really famous painting that somebody did 429 00:25:40,680 --> 00:25:42,320 Speaker 1: and it was just kind of lost to history who 430 00:25:42,359 --> 00:25:44,520 Speaker 1: did it? And I read this article. I can't remember 431 00:25:44,560 --> 00:25:48,040 Speaker 1: what it was on, but this person tracked down, um, 432 00:25:48,240 --> 00:25:50,840 Speaker 1: the artist, the initial artist, and got to see like 433 00:25:50,880 --> 00:25:53,280 Speaker 1: the original. Because it's been scanned so many times, it's 434 00:25:53,320 --> 00:25:56,600 Speaker 1: really lost a step. But um, the originals apparently really 435 00:25:56,600 --> 00:26:00,360 Speaker 1: something to see. Should we say the quote that head 436 00:26:00,359 --> 00:26:05,840 Speaker 1: in that science he said, he said, and they walked 437 00:26:05,840 --> 00:26:07,800 Speaker 1: in the office, he said. They were bluer in Hill, 438 00:26:09,200 --> 00:26:14,600 Speaker 1: very Kentucky. Alright. So over time, uh, a few gates 439 00:26:14,600 --> 00:26:17,919 Speaker 1: started moving away, like some of the younger population of 440 00:26:17,920 --> 00:26:21,959 Speaker 1: the family got out of Hazard County. And it's so 441 00:26:22,000 --> 00:26:23,960 Speaker 1: hard not to make Dukes of Hazzard jokes. I've been 442 00:26:24,000 --> 00:26:26,440 Speaker 1: just sidestepping the whole time. I've been doing really great, 443 00:26:26,760 --> 00:26:29,520 Speaker 1: thank you. But they started to move away over time, 444 00:26:29,680 --> 00:26:33,200 Speaker 1: and basically you know, that's gonna stop the inner breeding 445 00:26:33,280 --> 00:26:36,480 Speaker 1: and that's gonna make fewer and fewer blue babies. And 446 00:26:36,640 --> 00:26:42,720 Speaker 1: as of I think some were still blue, but not today. Yeah, 447 00:26:42,760 --> 00:26:45,439 Speaker 1: I think now that there's a treatment and easy treatment 448 00:26:45,440 --> 00:26:47,800 Speaker 1: because they don't even have to be injected anymore. Like 449 00:26:47,840 --> 00:26:49,480 Speaker 1: if you're blue and you don't want to be blue, 450 00:26:49,520 --> 00:26:52,600 Speaker 1: you just take a methylene blue pill once a day 451 00:26:52,720 --> 00:26:55,879 Speaker 1: and it goes in. Apparently once you excreted out the 452 00:26:55,960 --> 00:26:59,760 Speaker 1: methylene blue, you'd go back to being blue, so you 453 00:26:59,840 --> 00:27:03,360 Speaker 1: have to take it daily. But I'll bet there's members 454 00:27:03,359 --> 00:27:05,560 Speaker 1: of that family now and I'm just guessing here, but 455 00:27:06,000 --> 00:27:08,280 Speaker 1: um that are proudly blue now that they know that 456 00:27:08,320 --> 00:27:10,280 Speaker 1: they don't have to be blue, some of them I'll 457 00:27:10,320 --> 00:27:12,439 Speaker 1: bet make a choice to be blue as kind of 458 00:27:12,480 --> 00:27:15,560 Speaker 1: like a like a pride in their family heritage. I'm 459 00:27:15,600 --> 00:27:18,639 Speaker 1: guessing here. Well, the thing I saw that there was 460 00:27:18,760 --> 00:27:21,359 Speaker 1: one and that was the one in twelve that was 461 00:27:21,359 --> 00:27:25,000 Speaker 1: still blue, like by choice, I think, so, yeah, I 462 00:27:25,040 --> 00:27:28,760 Speaker 1: just didn't take the pillow. That's neat, But but not 463 00:27:28,840 --> 00:27:32,200 Speaker 1: today anymore. So this is uh not the only way 464 00:27:32,240 --> 00:27:36,440 Speaker 1: you can get bluish or any you know. I guess 465 00:27:36,440 --> 00:27:39,720 Speaker 1: silvery skin is another. There's another thing that comes into 466 00:27:39,720 --> 00:27:43,080 Speaker 1: play here with this next disorder, and this is one 467 00:27:43,160 --> 00:27:48,399 Speaker 1: called argeria. And some people are bluish, some people are silver. 468 00:27:49,040 --> 00:27:52,160 Speaker 1: If you've looked up you know blue people or silver 469 00:27:52,240 --> 00:27:56,639 Speaker 1: people online, you have no doubt seen uh Paul Harrison. 470 00:27:57,440 --> 00:28:00,200 Speaker 1: They called him Papa Smurf, and he is all over 471 00:28:00,200 --> 00:28:04,120 Speaker 1: the internet as one of the more famous cases of Algeria. Yeah, 472 00:28:04,119 --> 00:28:08,200 Speaker 1: and he was. He kind of emerged as I don't 473 00:28:08,240 --> 00:28:10,399 Speaker 1: know if a cautionary tale is right, because that was 474 00:28:10,440 --> 00:28:15,160 Speaker 1: not his purpose. Um, but he he also he whether 475 00:28:15,200 --> 00:28:17,760 Speaker 1: he meant to or not, he served as a cautionary 476 00:28:17,760 --> 00:28:21,840 Speaker 1: tale about taking colloidal silver because that is what turned 477 00:28:21,920 --> 00:28:24,119 Speaker 1: him blue. And it didn't just turn his skin blue. 478 00:28:24,119 --> 00:28:26,760 Speaker 1: It turned his mucous membranes blue. So if he like 479 00:28:27,080 --> 00:28:29,600 Speaker 1: flashed his teeth, his gums were blue, and the inside 480 00:28:29,640 --> 00:28:31,359 Speaker 1: of his mouth was blue, the inside of his nose 481 00:28:31,400 --> 00:28:34,159 Speaker 1: was blue. He was blue blue or in hell, as 482 00:28:34,240 --> 00:28:38,480 Speaker 1: Kawayne would probably put it um. And he he did 483 00:28:38,520 --> 00:28:41,760 Speaker 1: it because he saw an article about how um silver 484 00:28:41,880 --> 00:28:46,720 Speaker 1: eyeons basically restored some cut flower back to life again, 485 00:28:46,760 --> 00:28:49,160 Speaker 1: and he thought, well, that would be really something to 486 00:28:49,160 --> 00:28:52,000 Speaker 1: to to see what it can do on a human body. 487 00:28:52,400 --> 00:28:54,840 Speaker 1: I want to be a fresh daisy, right, And he 488 00:28:54,920 --> 00:28:58,080 Speaker 1: wasn't the only person at experimenting at the time, Like 489 00:28:58,120 --> 00:29:00,640 Speaker 1: apparently for a while it was a over the counter drug. 490 00:29:00,720 --> 00:29:03,920 Speaker 1: We've been using silver for a very long time. But 491 00:29:04,240 --> 00:29:08,520 Speaker 1: he was, um, somebody who used it every single day. 492 00:29:08,560 --> 00:29:11,720 Speaker 1: He was drinking like a ten ounce drink of colloidal silver. 493 00:29:11,760 --> 00:29:14,120 Speaker 1: He figured out how to basically make his own colloidal 494 00:29:14,160 --> 00:29:17,920 Speaker 1: silver potion, and he also rubbed it on his face too, 495 00:29:18,120 --> 00:29:20,680 Speaker 1: and so in very short order he started to turn blue. 496 00:29:20,800 --> 00:29:24,600 Speaker 1: Because that is definitely a consequence of using silver too 497 00:29:24,720 --> 00:29:28,200 Speaker 1: much of overexposure to silver, that's right. Uh, And this 498 00:29:28,240 --> 00:29:30,960 Speaker 1: can happen if you work in like a silver mine 499 00:29:31,160 --> 00:29:33,200 Speaker 1: or something like. It can be one of the side 500 00:29:33,240 --> 00:29:35,760 Speaker 1: effects of mining silver mine. I also saw that in 501 00:29:35,760 --> 00:29:38,560 Speaker 1: the old time, um, not even that old, but just 502 00:29:38,880 --> 00:29:45,680 Speaker 1: pre digital photography processing photograph processing, you could actually um yeah, 503 00:29:45,720 --> 00:29:49,520 Speaker 1: you know the eighties, Um, you could actually develop algeria 504 00:29:49,680 --> 00:29:53,040 Speaker 1: be from exposure to the silver dust that was used 505 00:29:53,040 --> 00:29:57,760 Speaker 1: to expose um photographic plates. I think prior to the eighties. 506 00:29:57,800 --> 00:30:00,520 Speaker 1: I I don't know when they stopped using that. I 507 00:30:00,560 --> 00:30:02,520 Speaker 1: don't either. I spent a lot of times in dark 508 00:30:02,600 --> 00:30:06,560 Speaker 1: rooms as a kid because my dad, because you were 509 00:30:06,560 --> 00:30:10,480 Speaker 1: a mad go in there, turn on that red light 510 00:30:10,480 --> 00:30:13,000 Speaker 1: and sit there and think about what you do. Now. 511 00:30:13,160 --> 00:30:15,560 Speaker 1: My dad was an amateur photographer, well I guess, and 512 00:30:15,640 --> 00:30:19,280 Speaker 1: my professionally sold stuff, but he did his own developing, 513 00:30:19,360 --> 00:30:22,040 Speaker 1: and um, I learned how to do it and did 514 00:30:22,040 --> 00:30:23,520 Speaker 1: it something through high school and then kind of quit 515 00:30:23,520 --> 00:30:24,640 Speaker 1: doing it. It It was a lot of fun. Though. Dark 516 00:30:24,680 --> 00:30:30,000 Speaker 1: rooms are very like peaceful places, is that right? Yeah? 517 00:30:30,160 --> 00:30:32,960 Speaker 1: Just you know they're dark obviously, and you're in there 518 00:30:33,000 --> 00:30:36,080 Speaker 1: for a long period of time, and it's just very nice, 519 00:30:36,160 --> 00:30:39,320 Speaker 1: usually by yourself, but unless you're in a teen romance 520 00:30:39,360 --> 00:30:41,040 Speaker 1: movie and then you know the cute girls in there 521 00:30:41,080 --> 00:30:43,520 Speaker 1: with you, I well, I always associate them with the 522 00:30:43,840 --> 00:30:46,880 Speaker 1: murderer finally coming into focus, and they happen to be 523 00:30:46,920 --> 00:30:50,800 Speaker 1: staying right next to the photographers developing it. So to me, 524 00:30:50,960 --> 00:30:55,200 Speaker 1: dark rooms are very tense, scary like as it as 525 00:30:55,320 --> 00:30:59,560 Speaker 1: the as the photo paper like comes into focus, very tense, 526 00:31:00,080 --> 00:31:05,440 Speaker 1: the calls coming from inside the dark room. That's right, Um, 527 00:31:05,480 --> 00:31:08,880 Speaker 1: where were we? Okay? So what causes this is an 528 00:31:08,880 --> 00:31:12,480 Speaker 1: excess of silver ions in your body and when they're 529 00:31:12,480 --> 00:31:15,400 Speaker 1: exposed to light, they react by forming dark deposits on 530 00:31:15,400 --> 00:31:18,760 Speaker 1: the skin that end up looking silver ish. And the 531 00:31:18,760 --> 00:31:21,720 Speaker 1: bad news about this is, once you've got it, it's there. 532 00:31:21,800 --> 00:31:23,480 Speaker 1: You can't take a pill and get rid of it. No, 533 00:31:23,680 --> 00:31:26,880 Speaker 1: it's irreversible. We don't have a way to remove excess 534 00:31:26,920 --> 00:31:29,880 Speaker 1: silver from the tissues and the human body. And that's 535 00:31:29,880 --> 00:31:32,280 Speaker 1: all it is. It's just it builds up. Normally, the 536 00:31:32,280 --> 00:31:35,200 Speaker 1: body can excrete you know, small amounts of silver that 537 00:31:35,240 --> 00:31:39,240 Speaker 1: we're exposed to from like you know, touching silver or 538 00:31:39,520 --> 00:31:44,760 Speaker 1: um snorting silver, that kind of stuff. Um, you know, uh, 539 00:31:45,120 --> 00:31:46,840 Speaker 1: like we pee it out, We poop it out and 540 00:31:46,880 --> 00:31:49,600 Speaker 1: we get rid of it. But if we overcome that 541 00:31:49,720 --> 00:31:54,000 Speaker 1: threshold and our silver ingestion um exceeds our ability to 542 00:31:54,080 --> 00:31:56,320 Speaker 1: excrete it, it starts to build up in the tissue. 543 00:31:56,600 --> 00:31:59,440 Speaker 1: And so if you're drinking your own tent outs colloidal 544 00:31:59,480 --> 00:32:05,200 Speaker 1: silver um homebrew every single day, you're going to overwhelm 545 00:32:05,280 --> 00:32:08,120 Speaker 1: your body's ability to excrete silver very quickly, and it's 546 00:32:08,120 --> 00:32:09,720 Speaker 1: going to build up and build up and build up, 547 00:32:09,720 --> 00:32:12,920 Speaker 1: and pretty soon you're going to be blue or silver blue, 548 00:32:13,600 --> 00:32:16,160 Speaker 1: that's right. Uh. And if you look up images of 549 00:32:16,640 --> 00:32:20,200 Speaker 1: Carrison you're probably also gonna find pictures of Stan Jones, 550 00:32:20,200 --> 00:32:24,760 Speaker 1: a libertarian politician in Montana who around why two K said, 551 00:32:24,760 --> 00:32:27,520 Speaker 1: you know what, I think things are gonna go south 552 00:32:27,600 --> 00:32:30,000 Speaker 1: and we're not gonna have any antibiotics. So I'm gonna 553 00:32:30,760 --> 00:32:35,000 Speaker 1: start making my own again colloidal silver solution and drink 554 00:32:35,040 --> 00:32:37,320 Speaker 1: that stuff. And then there was a teacher in Brooklyn, 555 00:32:37,400 --> 00:32:40,480 Speaker 1: too named Rosemary Jacobs, who uh, very sadly I think 556 00:32:40,520 --> 00:32:44,240 Speaker 1: got um nasal drops with silver when she was a kid, 557 00:32:44,800 --> 00:32:47,120 Speaker 1: and she was sort of not sort of she was 558 00:32:47,200 --> 00:32:50,720 Speaker 1: very silver for life. She was. So these people again 559 00:32:50,880 --> 00:32:54,200 Speaker 1: have proved to be cautionary tales to most people who 560 00:32:54,280 --> 00:32:56,600 Speaker 1: are like, oh, that's what happens if you take too 561 00:32:56,680 --> 00:32:59,920 Speaker 1: much silver. I'm not going to take colloidal silver saw 562 00:33:00,000 --> 00:33:03,360 Speaker 1: pplements over the counter, um anything like that. I'm just 563 00:33:03,400 --> 00:33:05,920 Speaker 1: gonna steer clear silver all together. Because one of the 564 00:33:05,920 --> 00:33:09,520 Speaker 1: problems is there's not a lot of pure reviewed evidence, 565 00:33:09,560 --> 00:33:14,040 Speaker 1: if any, that suggests that silver has any beneficial effect 566 00:33:14,280 --> 00:33:18,960 Speaker 1: when taken internally right, it is actually anti anti microbial. 567 00:33:18,960 --> 00:33:22,640 Speaker 1: It's pretty clever to um use silver like in the 568 00:33:22,720 --> 00:33:27,240 Speaker 1: pre scientific days, but there's nothing that says like, yes, 569 00:33:27,280 --> 00:33:30,400 Speaker 1: if you drink colloidal silver homebrew, it's going to have 570 00:33:30,480 --> 00:33:33,960 Speaker 1: any effect on your on your life or your health, 571 00:33:34,440 --> 00:33:37,440 Speaker 1: and in fact, it might actually turn you blue. Despite this, 572 00:33:37,840 --> 00:33:42,840 Speaker 1: people still take colloidal silver um pretty frequently. Apparently, Alex 573 00:33:42,920 --> 00:33:47,200 Speaker 1: Jones touts it, Gwyneth Paltrow touts it. Dr Oz touts it. 574 00:33:48,000 --> 00:33:50,800 Speaker 1: And that's you know, if it's not actually harming you, 575 00:33:50,840 --> 00:33:53,920 Speaker 1: there doesn't seem to be any any harm from it, 576 00:33:54,200 --> 00:33:58,400 Speaker 1: aside from potentially irreversibly turning blue. But there's a larger 577 00:33:58,480 --> 00:34:01,840 Speaker 1: harm that I saw chuck to society in general, and 578 00:34:01,920 --> 00:34:07,880 Speaker 1: that silver is a anti microbial of last resort, that is, um, 579 00:34:07,920 --> 00:34:11,440 Speaker 1: they're figuring out how to use it against um my 580 00:34:12,080 --> 00:34:16,120 Speaker 1: antibiotic resistant bugs like mersa. That silver will get in 581 00:34:16,120 --> 00:34:20,520 Speaker 1: there and even kill mersa. But that silver resistance may 582 00:34:20,560 --> 00:34:25,320 Speaker 1: be developed in bugs by all these people taking colloidal 583 00:34:25,360 --> 00:34:29,480 Speaker 1: silver supplements and drinking colloidal silver um, you know, homebrews 584 00:34:29,520 --> 00:34:33,759 Speaker 1: and stuff like that. That is actually creating silver resistant microbes, 585 00:34:33,840 --> 00:34:37,080 Speaker 1: which is not a good thing for anybody. All Right, Well, 586 00:34:37,120 --> 00:34:40,560 Speaker 1: let's take our second break, good, yes, and we'll talk 587 00:34:40,560 --> 00:34:42,640 Speaker 1: a little bit more about coloidal silver right after this. 588 00:35:02,640 --> 00:35:05,680 Speaker 1: All right, So you mentioned earlier that uh kind of 589 00:35:05,719 --> 00:35:09,120 Speaker 1: in passing that cloydal Silver had been used pre UM. 590 00:35:09,160 --> 00:35:13,000 Speaker 1: You know, mainstream medical science coming on board, and it's 591 00:35:13,080 --> 00:35:15,040 Speaker 1: really true, and they were kind of onto something and that, 592 00:35:15,120 --> 00:35:18,640 Speaker 1: like you said, there were there are some anti microbial properties. 593 00:35:18,640 --> 00:35:22,200 Speaker 1: So people like Plenty the Elder Cyrus to the Great 594 00:35:22,719 --> 00:35:26,040 Speaker 1: they both touted the use of silver. Monks in the 595 00:35:26,040 --> 00:35:30,480 Speaker 1: Middle Ages used silver nitrate UM to treat ulcers and burns, 596 00:35:31,160 --> 00:35:33,759 Speaker 1: and it was used a lot. It's it's kind of 597 00:35:34,120 --> 00:35:37,200 Speaker 1: in a way before we had real antibotics, one of 598 00:35:37,200 --> 00:35:43,279 Speaker 1: the first antibiotics. Yes, UM again externally, it messes up 599 00:35:43,320 --> 00:35:46,480 Speaker 1: microbs and we're not exactly sure even still today what 600 00:35:46,520 --> 00:35:50,160 Speaker 1: the mechanism is. The guesses are that somehow penetrates the 601 00:35:50,520 --> 00:35:54,319 Speaker 1: membrane of the of bacteria and prevents it from replicating 602 00:35:54,400 --> 00:35:59,719 Speaker 1: properly UM or it had it does like some one two, 603 00:36:00,000 --> 00:36:03,520 Speaker 1: which is on enzymes that the microbes need to to 604 00:36:03,560 --> 00:36:07,560 Speaker 1: survive UM, but that it it will leave your human 605 00:36:07,760 --> 00:36:13,359 Speaker 1: skin cells alone. It just attacks microbes weirdly bacteria specifically UM. 606 00:36:13,400 --> 00:36:16,759 Speaker 1: So yeah, it was like an early antibiotic and it 607 00:36:16,840 --> 00:36:20,480 Speaker 1: actually kept UM stayed in use for a long time 608 00:36:21,000 --> 00:36:23,880 Speaker 1: now to nowadays, you'll find it in like wound dressings. 609 00:36:23,920 --> 00:36:28,560 Speaker 1: Sometimes suitures will be coated in silver. Replacement joints artificial 610 00:36:28,640 --> 00:36:31,520 Speaker 1: joints will have some sort of silver component to it 611 00:36:31,600 --> 00:36:36,480 Speaker 1: to to protect um against infection UM. But we were 612 00:36:36,560 --> 00:36:39,040 Speaker 1: using them internally for a really long time up until 613 00:36:39,040 --> 00:36:41,759 Speaker 1: the sixties. Even I think babies got like silver eye 614 00:36:41,840 --> 00:36:44,640 Speaker 1: drops when they were born, which I had not heard 615 00:36:44,640 --> 00:36:48,640 Speaker 1: of until you know, yesterday. I had neither yes, silver 616 00:36:48,760 --> 00:36:53,000 Speaker 1: nitrate to prevent eye infections, but then they found out 617 00:36:53,000 --> 00:36:55,839 Speaker 1: it can actually cause eye damage and burn the skin. 618 00:36:56,000 --> 00:37:01,080 Speaker 1: So they really worked on UM just sort of, uh, 619 00:37:01,440 --> 00:37:03,319 Speaker 1: what's the word I'm looking for? When you make something 620 00:37:03,400 --> 00:37:08,520 Speaker 1: less potent by mixing it with water diluting it right 621 00:37:08,520 --> 00:37:11,560 Speaker 1: on the tip of my tongue, You did it, No, 622 00:37:11,719 --> 00:37:13,640 Speaker 1: you did it. So they learned how to dilute it. 623 00:37:14,000 --> 00:37:17,799 Speaker 1: But the problem with diluting it in a formula is 624 00:37:18,200 --> 00:37:20,920 Speaker 1: it wasn't an exact science, Like they didn't know exactly 625 00:37:20,920 --> 00:37:24,520 Speaker 1: how much silver was still going to be active, and 626 00:37:24,560 --> 00:37:27,400 Speaker 1: so you know, you couldn't really use it as a 627 00:37:27,440 --> 00:37:30,840 Speaker 1: medicine anymore because it was either too weak to do anything, 628 00:37:31,040 --> 00:37:33,400 Speaker 1: or it was so much that you risk turning blue. 629 00:37:33,960 --> 00:37:36,440 Speaker 1: So eventually they just scrapped it as a medicine and said, 630 00:37:36,800 --> 00:37:39,960 Speaker 1: I think in the FDA said this isn't a medicine. 631 00:37:39,960 --> 00:37:42,319 Speaker 1: You can't advertise it as such. So they said, all right, 632 00:37:42,320 --> 00:37:44,840 Speaker 1: well to say it's a supplement and just move it 633 00:37:44,880 --> 00:37:46,840 Speaker 1: to the shelf, you know, four ft away, and the 634 00:37:46,880 --> 00:37:50,879 Speaker 1: Ft said, and that's what happened, and you can still 635 00:37:50,880 --> 00:37:53,000 Speaker 1: get this stuff. That's where you know. That's why when 636 00:37:53,040 --> 00:37:56,320 Speaker 1: it's Paltrow uses it. Yeah. So, and I mean, like again, 637 00:37:56,320 --> 00:37:58,000 Speaker 1: it's one of those things where it's like, yes, it 638 00:37:58,080 --> 00:38:01,760 Speaker 1: makes sense. Silver has an anti microbial properties. There's probably 639 00:38:01,840 --> 00:38:04,560 Speaker 1: some microbes in your body you don't want um, so 640 00:38:04,760 --> 00:38:07,000 Speaker 1: take some silver and see if it works. But again, 641 00:38:07,320 --> 00:38:10,360 Speaker 1: there's just not any pure of viewed evidence that backs 642 00:38:10,400 --> 00:38:14,759 Speaker 1: this up. That's not necessarily to say that it doesn't work. 643 00:38:14,880 --> 00:38:17,680 Speaker 1: Just because there isn't pure viewed evidence that backs it 644 00:38:17,800 --> 00:38:20,440 Speaker 1: up doesn't also necessarily mean in the same breath that 645 00:38:20,480 --> 00:38:23,359 Speaker 1: there's plenty of pure viewed evidence that says it doesn't work. 646 00:38:23,719 --> 00:38:26,359 Speaker 1: I'm not suggesting anybody take the stuff. I'm just saying 647 00:38:26,440 --> 00:38:28,840 Speaker 1: there's not pure of viewed evidence to back up that 648 00:38:28,880 --> 00:38:32,200 Speaker 1: it actually does anything. And if you do take it again, 649 00:38:32,480 --> 00:38:38,279 Speaker 1: you risk permanently irreversibly turning blue. Yeah, and and I 650 00:38:38,280 --> 00:38:41,400 Speaker 1: should point out I don't know anything about Gwyneth Paltrow's 651 00:38:41,480 --> 00:38:47,000 Speaker 1: current usage, but this her appearance on Dr OZ was 652 00:38:47,040 --> 00:38:49,000 Speaker 1: when she touted it. She she may have given it up, 653 00:38:49,000 --> 00:38:51,960 Speaker 1: who knows? Who knows? Um. Paul Keason never gave it 654 00:38:52,000 --> 00:38:56,680 Speaker 1: up the chuck. He died in uh two thirteen as well, 655 00:38:56,719 --> 00:38:59,360 Speaker 1: same year that Gwyneth Paltrow outed herself as a silver 656 00:38:59,480 --> 00:39:05,120 Speaker 1: user um and Paul carrasan Uh. He apparently used colloidal 657 00:39:05,160 --> 00:39:08,319 Speaker 1: silver that homebrew he made up until the end. Like 658 00:39:08,440 --> 00:39:11,719 Speaker 1: he never stopped, even though he apparently retreated from the 659 00:39:11,719 --> 00:39:13,920 Speaker 1: public eye because he was tired of being treated like 660 00:39:13,920 --> 00:39:16,719 Speaker 1: a freak or a weirdo UM and had some rough 661 00:39:16,800 --> 00:39:20,440 Speaker 1: years towards the end apparently after he went public, but 662 00:39:20,520 --> 00:39:23,560 Speaker 1: he's still kept up with the colloidal silver, although that 663 00:39:23,680 --> 00:39:25,799 Speaker 1: doesn't seem to have been linked to his death. He 664 00:39:25,840 --> 00:39:28,719 Speaker 1: was also a really heavy smoker for many years, and 665 00:39:28,760 --> 00:39:32,839 Speaker 1: he suffered a heart attack and a stroke. Yeah. I mean, 666 00:39:32,880 --> 00:39:36,839 Speaker 1: I guess his point was probably while I'm already blue, Yeah, 667 00:39:37,000 --> 00:39:40,279 Speaker 1: like why stop? Now? You can't get much bluer? So uh, 668 00:39:40,520 --> 00:39:43,120 Speaker 1: what else you got? Well, I just thought we'd wind 669 00:39:43,120 --> 00:39:46,600 Speaker 1: it up with this little kind of sidebar. Uh. I 670 00:39:46,640 --> 00:39:48,839 Speaker 1: can't This doesn't really have any to do with being 671 00:39:48,880 --> 00:39:51,760 Speaker 1: blue or silver, but I thought it was an interesting 672 00:39:52,120 --> 00:39:56,560 Speaker 1: find that, uh, they basically determine. Uh, there's something called 673 00:39:56,560 --> 00:40:01,359 Speaker 1: repigmenting that has happened to people, uh to go their 674 00:40:01,400 --> 00:40:04,200 Speaker 1: skin both darker and lighter. That has nothing to do 675 00:40:04,320 --> 00:40:05,960 Speaker 1: that in this funny in this article kept calling it 676 00:40:06,000 --> 00:40:09,960 Speaker 1: inter marriage. Um, what they mean is you know or 677 00:40:10,360 --> 00:40:15,439 Speaker 1: or yeah, what they mean is having sex and having babies, uh, 678 00:40:15,760 --> 00:40:18,640 Speaker 1: two different skin colors. But they keep calling it inter marriage, 679 00:40:18,640 --> 00:40:20,960 Speaker 1: which I guess is uh, you know, very sweet. It's 680 00:40:21,000 --> 00:40:24,440 Speaker 1: just such a lovely way to put it. It's but 681 00:40:24,600 --> 00:40:29,440 Speaker 1: they know that repigmenting happens regardless of uh, inter marriage. 682 00:40:29,960 --> 00:40:32,640 Speaker 1: But what they found recently is that this has happened 683 00:40:32,680 --> 00:40:36,200 Speaker 1: a lot faster than anyone thought. And we're talking about 684 00:40:36,239 --> 00:40:39,920 Speaker 1: a hundred generations, or as little as a hundred generations, 685 00:40:39,920 --> 00:40:42,040 Speaker 1: which is a long time, but over the course of 686 00:40:42,320 --> 00:40:44,719 Speaker 1: human history, it's not that long. It's potentially not. Yeah, 687 00:40:44,719 --> 00:40:47,239 Speaker 1: it's not that long. Usually a generation is chalked up 688 00:40:47,239 --> 00:40:49,640 Speaker 1: at about twenty years, So we're talking as little as 689 00:40:49,640 --> 00:40:54,479 Speaker 1: two thousand years, groups that were once lily white went 690 00:40:54,560 --> 00:40:57,319 Speaker 1: back to being dark, and groups that were dark can 691 00:40:57,440 --> 00:41:01,640 Speaker 1: turn into a lily white population, and that it's it's 692 00:41:01,680 --> 00:41:05,759 Speaker 1: it's just basically more evidence that race is strictly a 693 00:41:05,840 --> 00:41:09,240 Speaker 1: social construct. Skin color has nothing to do with anything 694 00:41:09,360 --> 00:41:12,640 Speaker 1: but the amount of melanin that our genes tell our 695 00:41:12,680 --> 00:41:15,319 Speaker 1: bodies to produce, which is triggered by the amount of 696 00:41:15,480 --> 00:41:20,879 Speaker 1: UV exposure that we have over something like a hundred generations, right, 697 00:41:21,000 --> 00:41:25,240 Speaker 1: And so if you're family lineage moves from a place 698 00:41:26,200 --> 00:41:28,719 Speaker 1: that has lots of UV near the equator to a 699 00:41:28,719 --> 00:41:32,040 Speaker 1: place that doesn't how much daylight or vice versa, your 700 00:41:32,040 --> 00:41:34,680 Speaker 1: body is going to adapt and melanin production is going 701 00:41:34,719 --> 00:41:38,960 Speaker 1: to change, and over time, your entire family's skin color 702 00:41:39,040 --> 00:41:42,080 Speaker 1: can change. Yeah, because we actually need UV, right, but 703 00:41:42,160 --> 00:41:43,640 Speaker 1: we just need a certain amount of it. If you 704 00:41:43,680 --> 00:41:46,680 Speaker 1: have too much, you can get skin cancer. Apparently, it 705 00:41:46,719 --> 00:41:50,719 Speaker 1: can have reproductive issues. If you get too little. It 706 00:41:50,800 --> 00:41:53,160 Speaker 1: can also have issues on your bone because we use 707 00:41:53,360 --> 00:41:56,120 Speaker 1: UV to produce vitamin D, which we use for for 708 00:41:56,200 --> 00:41:59,200 Speaker 1: strong bones bone density. So our bodies have figured out 709 00:41:59,200 --> 00:42:02,320 Speaker 1: how to kind of adjust depending on that you V 710 00:42:02,480 --> 00:42:07,480 Speaker 1: exposure by producing or slowing down melanin production. That's it 711 00:42:07,560 --> 00:42:11,320 Speaker 1: pretty amazing, pretty neat. But it is surprising that it's well, actually, 712 00:42:11,320 --> 00:42:13,239 Speaker 1: it's not that surprising that it can happen over a 713 00:42:13,280 --> 00:42:16,440 Speaker 1: hundred generations or two thousand years because the body is 714 00:42:16,560 --> 00:42:20,120 Speaker 1: very responsive to its environment. We adapt very easily, so 715 00:42:20,640 --> 00:42:24,360 Speaker 1: that's not particularly surprising, although it is neat. Yeah, I 716 00:42:24,400 --> 00:42:26,560 Speaker 1: mean it's surprised the scientist. I think they just thought 717 00:42:26,560 --> 00:42:30,840 Speaker 1: it was quicker than they anticipated. So if you're a racist, 718 00:42:31,280 --> 00:42:34,120 Speaker 1: just stop and think that somewhere down your family line 719 00:42:34,320 --> 00:42:38,560 Speaker 1: there is a white person or a black person or 720 00:42:38,600 --> 00:42:41,399 Speaker 1: in the future. Yeah, that's true. That's right. So take that. 721 00:42:42,360 --> 00:42:45,719 Speaker 1: You got anything else? I have nothing else? All right, Well, 722 00:42:45,760 --> 00:42:47,880 Speaker 1: if you want to know more about blue people or 723 00:42:48,040 --> 00:42:51,400 Speaker 1: colloidal silver or pigmentation, go start reading up on it 724 00:42:51,440 --> 00:42:53,920 Speaker 1: on the internet. Uh. And thanks again to all the 725 00:42:53,960 --> 00:42:56,600 Speaker 1: great sites that you found in putting this really good 726 00:42:56,760 --> 00:43:01,080 Speaker 1: episode together, Chuck. And since I complimented talks episode putting 727 00:43:01,120 --> 00:43:06,200 Speaker 1: together skills, it's time for a listener mail. I'm gonna 728 00:43:06,200 --> 00:43:09,960 Speaker 1: call this, uh, one of the many thanks we got 729 00:43:10,000 --> 00:43:13,200 Speaker 1: for the m Not in Array, but the the Mr 730 00:43:13,320 --> 00:43:16,640 Speaker 1: Not episode, Uh, this is one I think for both 731 00:43:16,680 --> 00:43:19,279 Speaker 1: of us like we were super stoked to do and 732 00:43:19,360 --> 00:43:23,000 Speaker 1: like in retrospect, very proud of you know, we're stoked. 733 00:43:23,480 --> 00:43:28,680 Speaker 1: We were super stoked, not just stoked stoked. Plus, there's 734 00:43:28,680 --> 00:43:31,480 Speaker 1: no way to say stoked without sounding like the bro. No, 735 00:43:31,480 --> 00:43:34,520 Speaker 1: no way at all. It stinks too because I'm not 736 00:43:34,560 --> 00:43:36,479 Speaker 1: a bro, but I do like things stoked. That's fine 737 00:43:36,560 --> 00:43:39,160 Speaker 1: to say stoked, be loud and proud, like the last 738 00:43:39,160 --> 00:43:42,480 Speaker 1: remaining blue fugate. So this is from Mark, and it 739 00:43:42,560 --> 00:43:44,680 Speaker 1: was a really long one that I'm gonna just sort 740 00:43:44,680 --> 00:43:47,920 Speaker 1: of summarize. The first part, uh, is that Mark works 741 00:43:47,920 --> 00:43:52,000 Speaker 1: in healthcare information technology and had a rough go of 742 00:43:52,040 --> 00:43:54,040 Speaker 1: it over the past couple of years, like so many people, 743 00:43:54,920 --> 00:43:59,439 Speaker 1: um working alone and uh listening to our show, which 744 00:43:59,600 --> 00:44:02,480 Speaker 1: he said help quite a bit, losing some close friends 745 00:44:02,480 --> 00:44:05,920 Speaker 1: to COVID and seeing all this up close and personal. 746 00:44:06,040 --> 00:44:09,040 Speaker 1: So Mark had a tough time. So he says this, 747 00:44:09,800 --> 00:44:13,680 Speaker 1: after working for almost two years on the COVID nineteen problem, 748 00:44:13,719 --> 00:44:16,280 Speaker 1: the last thing I wanted to hear was your podcast 749 00:44:16,400 --> 00:44:20,799 Speaker 1: about Mr No vaccines. When I saw the topic pop 750 00:44:20,880 --> 00:44:23,080 Speaker 1: up on my player, took a deep breath and decided 751 00:44:23,120 --> 00:44:25,600 Speaker 1: to listen. Anyway, I knew almost everything you shared on 752 00:44:25,640 --> 00:44:28,680 Speaker 1: the podcast, but became enthralled in the recap of this 753 00:44:28,719 --> 00:44:32,560 Speaker 1: amazing story. To my surprise, I was again brought to 754 00:44:32,680 --> 00:44:35,880 Speaker 1: tears with a recognition one that you two share of 755 00:44:35,920 --> 00:44:38,520 Speaker 1: these brilliant helpers who use their gifts for the benefit 756 00:44:38,560 --> 00:44:41,800 Speaker 1: of all humanity. At the risk of making you blush. 757 00:44:41,840 --> 00:44:44,520 Speaker 1: You two are part of those helpers. You presented this 758 00:44:44,640 --> 00:44:49,120 Speaker 1: mr NA episode with the childlike curiosity and relatable simplicity 759 00:44:49,160 --> 00:44:52,000 Speaker 1: that anyone with doubts on taking the vaccine would reconsider. 760 00:44:52,920 --> 00:44:55,080 Speaker 1: I can't believe that I have to say this, but 761 00:44:55,239 --> 00:44:59,719 Speaker 1: facts help and fact shares are helpers. I might also 762 00:44:59,760 --> 00:45:01,600 Speaker 1: add that letting go of any bias is to let 763 00:45:01,600 --> 00:45:05,560 Speaker 1: your curiosity curiosity take hold is heroic. Uh. And that 764 00:45:05,719 --> 00:45:08,719 Speaker 1: is from Mark, and boy, I'm gonna read that one 765 00:45:08,719 --> 00:45:11,400 Speaker 1: another hundred times today. Yeah. Just print it out and 766 00:45:11,440 --> 00:45:13,959 Speaker 1: fold it up and keep it under your pillow. Yes, 767 00:45:14,040 --> 00:45:15,960 Speaker 1: thank you Mark. He wanted his last name to be 768 00:45:16,000 --> 00:45:18,319 Speaker 1: with help but appreciates Mark. You've done Mark, and hang 769 00:45:18,360 --> 00:45:20,839 Speaker 1: in there. Yeah. Same same to you, Mark. And UM, 770 00:45:21,120 --> 00:45:22,920 Speaker 1: that was very high praise. Thank you very much for 771 00:45:23,000 --> 00:45:26,360 Speaker 1: it means a lot to hear something like that. Um. 772 00:45:26,480 --> 00:45:29,759 Speaker 1: One other thing they chuck that that Mark reminded me 773 00:45:29,840 --> 00:45:34,920 Speaker 1: of that people with matima globe anemia actually can blush blue. 774 00:45:36,880 --> 00:45:39,719 Speaker 1: Oh so they get bluer. Yeah in that neat, I 775 00:45:39,719 --> 00:45:42,160 Speaker 1: guess that makes sense. Thanks for that to Mark, even 776 00:45:42,160 --> 00:45:44,359 Speaker 1: though you had no idea, you're setting us up for it. 777 00:45:44,440 --> 00:45:48,400 Speaker 1: You did, so you're just basically a an altogether great person. 778 00:45:48,960 --> 00:45:50,839 Speaker 1: If you want to be a great person like Mark 779 00:45:50,880 --> 00:45:53,239 Speaker 1: and right in to let us know whatever you want 780 00:45:53,239 --> 00:45:55,080 Speaker 1: to let us know we want to hear from you, 781 00:45:55,080 --> 00:45:56,880 Speaker 1: you can wrap it up and spank it on that 782 00:45:56,960 --> 00:46:00,920 Speaker 1: bottom until it's blue in the case and send it 783 00:46:00,960 --> 00:46:06,920 Speaker 1: off to Stuff Podcasts at iHeart radio dot com. Stuff 784 00:46:06,960 --> 00:46:08,960 Speaker 1: you Should Know is a production of I heart Radio. 785 00:46:09,440 --> 00:46:12,600 Speaker 1: For more podcasts my heart Radio, visit the iHeart Radio app, 786 00:46:12,800 --> 00:46:15,680 Speaker 1: Apple Podcasts, or wherever you listen to your favorite shows. 787 00:46:18,560 --> 00:46:18,600 Speaker 1: H