WEBVTT - Heartbeat in the Brain, Hole in the Skull

0:00:03.120 --> 0:00:06.000
<v Speaker 1>Welcome to Stuff to Blow your Mind from how Stuff

0:00:06.000 --> 0:00:13.400
<v Speaker 1>Works dot com. Hey, welcome to Stuff to Blow your Mind.

0:00:13.400 --> 0:00:15.960
<v Speaker 1>My name is Robert Lamb and I'm Julie Douglas. And

0:00:16.000 --> 0:00:21.000
<v Speaker 1>you know, summer's here and with summer comesfation drilling holes

0:00:21.040 --> 0:00:25.280
<v Speaker 1>in your skull to uh improve your mindset, to treat

0:00:25.320 --> 0:00:28.120
<v Speaker 1>the traumatic injuries, that sort of thing. Yeah, people often

0:00:28.120 --> 0:00:32.279
<v Speaker 1>think summer pools swimming, but what about creating pool in

0:00:32.320 --> 0:00:36.919
<v Speaker 1>your forehead? Indeed, Yeah, So we are going to rerun

0:00:37.360 --> 0:00:40.559
<v Speaker 1>this episode because we have a special uh hole in

0:00:40.600 --> 0:00:43.919
<v Speaker 1>our hearts, hole in our brains for this um for

0:00:43.960 --> 0:00:46.320
<v Speaker 1>this episode, and we hope you enjoy. And also wanted

0:00:46.360 --> 0:00:48.839
<v Speaker 1>to mention that if you don't know about the stud

0:00:48.920 --> 0:00:54.600
<v Speaker 1>it's called the NIB dot com. Uh. Emmy Dennis, a cartoonist,

0:00:54.680 --> 0:00:57.600
<v Speaker 1>has a great little bit on trepi Nation here is.

0:00:57.640 --> 0:01:00.320
<v Speaker 1>She even recreates one of these trepre Nations posts that

0:01:00.360 --> 0:01:04.320
<v Speaker 1>we talk about. Well, I'll make sure to include a

0:01:04.360 --> 0:01:06.640
<v Speaker 1>link to that on the landing page of this episode,

0:01:06.680 --> 0:01:08.560
<v Speaker 1>as well as a link to a new Forbes article

0:01:08.720 --> 0:01:11.360
<v Speaker 1>that came out. It has to do with three a

0:01:11.400 --> 0:01:15.200
<v Speaker 1>trepan skulls from the Copacabana Peninsula. And the Kitty Kaka

0:01:15.240 --> 0:01:19.280
<v Speaker 1>Basin of Olivia and these days back somewhere between BC

0:01:19.640 --> 0:01:23.400
<v Speaker 1>and A thousand, uh see, so it's pretty interesting stuff.

0:01:23.480 --> 0:01:25.720
<v Speaker 1>Will also include a link to the video we did

0:01:26.480 --> 0:01:29.640
<v Speaker 1>because there's a there's some particular footage that we mentioned

0:01:29.760 --> 0:01:32.319
<v Speaker 1>in the episode and you might be thinking, oh, I'd

0:01:32.319 --> 0:01:34.120
<v Speaker 1>really love to see that. You might think you would

0:01:34.120 --> 0:01:36.560
<v Speaker 1>love to see that, and if you would, then check

0:01:36.600 --> 0:01:39.480
<v Speaker 1>out the video. I'll include the link on the landing page. Indeed,

0:01:50.520 --> 0:01:53.840
<v Speaker 1>this episode of Stuff to Blow Your Mind does in

0:01:53.920 --> 0:01:59.000
<v Speaker 1>fact deal with the brain, the physical aspect of the mind,

0:01:59.720 --> 0:02:04.480
<v Speaker 1>and some rather radical things that have and can be

0:02:04.560 --> 0:02:07.160
<v Speaker 1>done to it, like drilling a hole in it, yes,

0:02:07.760 --> 0:02:10.400
<v Speaker 1>or particularly drilling a hole in the skull to create

0:02:10.400 --> 0:02:12.560
<v Speaker 1>a pathway to the brain. Yes, that kind of a

0:02:12.560 --> 0:02:15.600
<v Speaker 1>cranial release point. Yeah. I mean, we are talking about

0:02:15.639 --> 0:02:20.120
<v Speaker 1>trepid nation, which is something that has been performed since

0:02:20.280 --> 0:02:24.040
<v Speaker 1>prehistoric times, and we'll get more into that, but it's

0:02:24.120 --> 0:02:27.200
<v Speaker 1>pretty much mostly associated with which doctors. But we're going

0:02:27.280 --> 0:02:30.680
<v Speaker 1>to talk about it today in a medical sense, historical sense,

0:02:30.880 --> 0:02:34.360
<v Speaker 1>and what it may or may not have to do

0:02:34.639 --> 0:02:38.760
<v Speaker 1>with Alzheimer's. Yes, um, I do want to just go

0:02:38.800 --> 0:02:40.200
<v Speaker 1>ahead and get this out of the way right now,

0:02:40.240 --> 0:02:42.720
<v Speaker 1>and we'll probably touch on this some more. But no

0:02:42.720 --> 0:02:45.280
<v Speaker 1>matter what you hear in this episode, do not drill

0:02:45.320 --> 0:02:48.320
<v Speaker 1>a hole in your skull or the skulls of anyone

0:02:48.360 --> 0:02:52.320
<v Speaker 1>you know. Um, it's a bad idea best left to

0:02:52.600 --> 0:02:56.160
<v Speaker 1>professionals that you know. We we have caution you guys

0:02:56.200 --> 0:02:58.360
<v Speaker 1>a lot before. We've talked about like you get stung

0:02:58.360 --> 0:03:01.880
<v Speaker 1>by uh jelly fish, do not pee on yourself for others,

0:03:01.960 --> 0:03:04.160
<v Speaker 1>because it's not gonna work. It might actually make things worse.

0:03:04.320 --> 0:03:07.600
<v Speaker 1>But we are super serious when we talk about trepen nation. Um,

0:03:07.639 --> 0:03:09.480
<v Speaker 1>and we're kind of laughing about it right now. But

0:03:10.000 --> 0:03:13.960
<v Speaker 1>as we will go into later, people have performed self

0:03:14.000 --> 0:03:17.560
<v Speaker 1>trepennations before and we'll talk about the reasons for that.

0:03:17.600 --> 0:03:20.680
<v Speaker 1>But again, this is something that is uh, it's just

0:03:20.720 --> 0:03:22.800
<v Speaker 1>not something that you do. I mean, it's brain surgery,

0:03:23.000 --> 0:03:27.200
<v Speaker 1>right exactly. And uh, in a sense, the the oldest

0:03:27.240 --> 0:03:30.560
<v Speaker 1>form of brain surgery now when we're talking about about

0:03:30.520 --> 0:03:34.640
<v Speaker 1>trepid nation. Essentially, this is the surgical removal of bone segments,

0:03:35.160 --> 0:03:38.520
<v Speaker 1>often circular, but sometimes it will be a square. It varies,

0:03:38.560 --> 0:03:41.240
<v Speaker 1>but but you see a lot of circles from the

0:03:41.280 --> 0:03:44.240
<v Speaker 1>skull in order to treat the symptoms of real or

0:03:44.280 --> 0:03:51.160
<v Speaker 1>imagine brain maladies. It was practiced by the ancient Egyptians, Chinese, Indians, Romans, Greeks,

0:03:51.240 --> 0:03:56.440
<v Speaker 1>and the early Mesoamerican civilizations. The earliest example that has

0:03:56.440 --> 0:03:58.880
<v Speaker 1>been found of a skull with trepen nation marks goes

0:03:58.960 --> 0:04:01.560
<v Speaker 1>back to the beginning of the Neolithic period some ten

0:04:01.640 --> 0:04:05.240
<v Speaker 1>thousand years ago, and the procedure is still performed today,

0:04:05.960 --> 0:04:10.360
<v Speaker 1>both for medical and non medical reasons. Yeah, today doctors

0:04:10.360 --> 0:04:15.080
<v Speaker 1>tend to call it a craniotomy instead of trepidation, just

0:04:15.080 --> 0:04:17.919
<v Speaker 1>because trepination is kind of a for many good reasons,

0:04:18.040 --> 0:04:20.520
<v Speaker 1>kind of a stigmatized term, because it does just bring

0:04:20.560 --> 0:04:23.000
<v Speaker 1>to mind drilling a hole through the skull and uh,

0:04:23.240 --> 0:04:25.279
<v Speaker 1>as as we'll discussed, there's a lot of baggage that

0:04:25.279 --> 0:04:27.200
<v Speaker 1>comes with that. A lot of that baggage it does

0:04:27.240 --> 0:04:29.599
<v Speaker 1>not deserve, but some of it it does. Yeah, and

0:04:29.640 --> 0:04:32.640
<v Speaker 1>when doctors do it today, it's because there's been some

0:04:32.680 --> 0:04:36.159
<v Speaker 1>sort of head trauma and uh, some sort of injury

0:04:36.360 --> 0:04:39.200
<v Speaker 1>that now only a sort of trepination would help to

0:04:39.240 --> 0:04:41.560
<v Speaker 1>reduce swelling in the build up of blood and other

0:04:41.640 --> 0:04:44.640
<v Speaker 1>fluids which can kill brain cells. Yeah, we're talking about

0:04:45.360 --> 0:04:50.360
<v Speaker 1>epidural or subdural hematomas here. Uh. And and also portions

0:04:50.360 --> 0:04:52.719
<v Speaker 1>of the skull will be reviewed, will be removed in

0:04:52.839 --> 0:04:56.440
<v Speaker 1>order to access parts of the brain. And in those cases,

0:04:56.880 --> 0:04:59.640
<v Speaker 1>of course we're taking this brain flap off in your

0:05:00.080 --> 0:05:03.480
<v Speaker 1>replacing it with a titanium plate, uh, screwing it on,

0:05:04.200 --> 0:05:06.359
<v Speaker 1>or using some of the forum to to fix it

0:05:06.800 --> 0:05:09.520
<v Speaker 1>back in position. Yeah, And then again these are our

0:05:09.560 --> 0:05:13.560
<v Speaker 1>medical reasons for undergoing this procedure. Non medical, there there

0:05:13.560 --> 0:05:17.200
<v Speaker 1>are quite a few reasons, it turns out, through history,

0:05:17.240 --> 0:05:20.440
<v Speaker 1>and one could be a kind of symbolic trepanning, in

0:05:20.480 --> 0:05:23.080
<v Speaker 1>which you know, there's not there is a little bit

0:05:23.120 --> 0:05:24.600
<v Speaker 1>of a hole made in the head, that it's more

0:05:24.640 --> 0:05:27.640
<v Speaker 1>of a symbolic thing, a sort of third eye that

0:05:27.760 --> 0:05:30.640
<v Speaker 1>mystics might say that you know, would help to expand

0:05:30.680 --> 0:05:35.320
<v Speaker 1>your consciousness. Um, I do know that. Archaeologist Bob Arnott says,

0:05:35.360 --> 0:05:38.320
<v Speaker 1>and this isn't a new scientist article the skull doctors

0:05:38.360 --> 0:05:41.680
<v Speaker 1>that some holes were made after death as part of

0:05:41.680 --> 0:05:44.320
<v Speaker 1>a burial right or to allow removal of the brain

0:05:44.520 --> 0:05:47.839
<v Speaker 1>before mommification. And he says that in some societies people

0:05:47.880 --> 0:05:50.880
<v Speaker 1>actually wore bone ambulance little discs that were cut out

0:05:50.920 --> 0:05:53.960
<v Speaker 1>from the skull of a leader or a great warrior.

0:05:54.200 --> 0:05:58.000
<v Speaker 1>So it's kind of like the the whole symbolic transaction

0:05:58.040 --> 0:05:59.839
<v Speaker 1>that happens there. If you have a little bit of

0:06:00.560 --> 0:06:04.240
<v Speaker 1>warrior or leader, perhaps you possess some of their power. Yeah,

0:06:04.880 --> 0:06:11.279
<v Speaker 1>and undoubted, undoubtedly trepid nation was used to treat various headaches, epilepsy,

0:06:11.400 --> 0:06:14.760
<v Speaker 1>mental disorders. There's even in the most basic forms of

0:06:14.800 --> 0:06:18.320
<v Speaker 1>trepid nation, with like the least medical ideas, there's still

0:06:18.320 --> 0:06:21.880
<v Speaker 1>this notion that there is an essential link between what's

0:06:21.880 --> 0:06:25.719
<v Speaker 1>going on inside the skull and the human condition and

0:06:25.760 --> 0:06:29.960
<v Speaker 1>your experience of reality, and that you can somehow adjustice,

0:06:30.080 --> 0:06:33.599
<v Speaker 1>tap into it, treat it by breaking down the barrier

0:06:33.720 --> 0:06:37.080
<v Speaker 1>between the world and the brain. Um and in this

0:06:37.320 --> 0:06:40.680
<v Speaker 1>you do see some of these ideas there in many

0:06:40.720 --> 0:06:44.800
<v Speaker 1>cases misapplied, but undoubtedly there have been holes drilled in

0:06:44.839 --> 0:06:48.919
<v Speaker 1>heads to release spirits, demons, etcetera. Yeah, the spirit and

0:06:48.960 --> 0:06:52.320
<v Speaker 1>demons things is something that that seems as though the

0:06:52.360 --> 0:06:56.880
<v Speaker 1>Western world has applied to what they might have deemed

0:06:56.880 --> 0:06:59.400
<v Speaker 1>as a primitive culture. Yeah, I think it's it's from

0:06:59.440 --> 0:07:03.080
<v Speaker 1>what I've read, is definitely overstated, but it's difficult for

0:07:03.120 --> 0:07:05.359
<v Speaker 1>anyone to say, no one ever drilled a hole in

0:07:05.360 --> 0:07:10.120
<v Speaker 1>the head to release the spirit or demon. But but

0:07:10.200 --> 0:07:12.320
<v Speaker 1>it is, it is over applied, and we'll get into

0:07:12.360 --> 0:07:14.280
<v Speaker 1>the details on that. It kind of gets, you know, treprenation,

0:07:14.320 --> 0:07:17.160
<v Speaker 1>gets into that weird territory that cannibalism gets into, where

0:07:17.160 --> 0:07:20.520
<v Speaker 1>there's so much myth and it's freighted with with so

0:07:20.600 --> 0:07:23.720
<v Speaker 1>much morality that it's sometimes hard to suess out the

0:07:23.760 --> 0:07:27.880
<v Speaker 1>truth from fiction. Over a historical amount of time, Yeah,

0:07:27.920 --> 0:07:32.080
<v Speaker 1>because certainly, especially really you know, Western European culture in

0:07:32.160 --> 0:07:36.320
<v Speaker 1>the over the last a few centuries, really into the

0:07:36.360 --> 0:07:40.720
<v Speaker 1>ideas of primitive, primitive people's or people who were deemed

0:07:40.720 --> 0:07:44.720
<v Speaker 1>as primitive eating each other and eating foreigners. Uh, certainly

0:07:44.720 --> 0:07:47.040
<v Speaker 1>into the idea of of some sort of a primitive

0:07:47.040 --> 0:07:50.000
<v Speaker 1>witch doctor just uh, you know, treating some sort of

0:07:50.000 --> 0:07:53.680
<v Speaker 1>malady by saying, oh, must free ghost from skull with

0:07:53.720 --> 0:07:57.280
<v Speaker 1>hammered you know, because it's just it's it's a demeaning ideas.

0:07:58.080 --> 0:08:04.400
<v Speaker 1>It limits those individuals to most primitive modes of human behavior. Yeah.

0:08:04.520 --> 0:08:07.280
<v Speaker 1>But then we have seen this in in Westerners for

0:08:07.320 --> 0:08:09.720
<v Speaker 1>a long time, this idea that you know, a Western

0:08:09.920 --> 0:08:12.440
<v Speaker 1>must be much more sophisticated. So therefore it must be

0:08:12.560 --> 0:08:14.560
<v Speaker 1>that they felt as though they were possessed by demon

0:08:14.560 --> 0:08:17.200
<v Speaker 1>and they had to let it out. But according to

0:08:17.320 --> 0:08:21.880
<v Speaker 1>Dr John Verano, who looked at something like ten years

0:08:22.000 --> 0:08:26.720
<v Speaker 1>of schools that we're in museums and private collections in

0:08:26.720 --> 0:08:28.200
<v Speaker 1>the U s and prow and he came to the

0:08:28.200 --> 0:08:32.280
<v Speaker 1>conclusion that there's plenty of evidence for advanced surgical skills

0:08:32.320 --> 0:08:35.600
<v Speaker 1>among the prehistoric people of the Andies. So that's for

0:08:35.640 --> 0:08:39.000
<v Speaker 1>one um. And if you start to look at this

0:08:39.040 --> 0:08:41.960
<v Speaker 1>a little bit more, then you you will stumble across

0:08:42.160 --> 0:08:46.680
<v Speaker 1>someone called Ephraim George Squire, who back in eighteen sixty

0:08:46.720 --> 0:08:50.080
<v Speaker 1>three already knew this. He already suspected this um, but

0:08:50.200 --> 0:08:54.480
<v Speaker 1>he actually had a different hypothesis of why this was,

0:08:54.520 --> 0:08:57.240
<v Speaker 1>and it didn't have anything to do with demons um.

0:08:57.280 --> 0:09:00.000
<v Speaker 1>He was an American diplomat and he was journeying across

0:09:00.559 --> 0:09:03.760
<v Speaker 1>Peru when he met Senora Zanito, who had in her

0:09:03.760 --> 0:09:08.800
<v Speaker 1>possession a skull with a perfectly square uh cut in it.

0:09:09.320 --> 0:09:12.400
<v Speaker 1>And what he notices that it had healing scar marks

0:09:12.440 --> 0:09:14.800
<v Speaker 1>and it had new bone growth, which would indicate the

0:09:14.840 --> 0:09:19.600
<v Speaker 1>person whoever inhabited that school before survived the trepid nation. Yeah,

0:09:19.640 --> 0:09:21.680
<v Speaker 1>they were healing, They were going on with their lives

0:09:22.320 --> 0:09:27.080
<v Speaker 1>despite and maybe even because of this hole. That's right.

0:09:27.120 --> 0:09:28.680
<v Speaker 1>This if you want to look more into this to

0:09:28.840 --> 0:09:32.640
<v Speaker 1>this specific example, it is from the mental fALS article headcase,

0:09:33.480 --> 0:09:38.040
<v Speaker 1>and it goes into detailing trepid nation in various ways.

0:09:38.240 --> 0:09:41.160
<v Speaker 1>And Squire, who is a rather interesting individual on his own,

0:09:41.200 --> 0:09:43.800
<v Speaker 1>I mean, a self taught archaeologist that was sent by

0:09:43.840 --> 0:09:47.280
<v Speaker 1>Abraham Lincoln to South America to deal with the guano,

0:09:48.000 --> 0:09:51.080
<v Speaker 1>the guana guano business, the guano problem, and then he

0:09:51.200 --> 0:09:55.960
<v Speaker 1>ends up immersed in this issue of of these skulls

0:09:56.000 --> 0:10:00.160
<v Speaker 1>in ancient neurosurgery. And and and at the time, you know,

0:10:00.200 --> 0:10:03.880
<v Speaker 1>we were talking about Western ideals and not what primitives,

0:10:04.520 --> 0:10:09.040
<v Speaker 1>primitive so called primitive societies did and do. Um. This

0:10:09.120 --> 0:10:12.880
<v Speaker 1>was a time where certainly that western white Westerners we

0:10:13.320 --> 0:10:17.440
<v Speaker 1>were like to view themselves as this superior species, almost

0:10:17.640 --> 0:10:21.000
<v Speaker 1>certainly a superior race, and everybody uh else was just

0:10:21.120 --> 0:10:25.080
<v Speaker 1>kind of piddling about. So the idea that ancient ancient

0:10:25.559 --> 0:10:29.959
<v Speaker 1>Meso Americans had advanced neurosurgery was kind of was a

0:10:30.360 --> 0:10:33.520
<v Speaker 1>radical idea, and in some sense it's a dangerous idea

0:10:34.080 --> 0:10:36.960
<v Speaker 1>to those who wanted to hold onto these these notions

0:10:37.000 --> 0:10:40.120
<v Speaker 1>of Western superiority. That's right, because we'll talk more about

0:10:40.160 --> 0:10:42.560
<v Speaker 1>this in a little bit. But you know, nineteenth century,

0:10:42.520 --> 0:10:46.640
<v Speaker 1>they're not having a lot of success with the procedure itself,

0:10:46.679 --> 0:10:50.040
<v Speaker 1>and it had been largely abandoned by this time. So

0:10:50.200 --> 0:10:53.600
<v Speaker 1>to think that a civilization, um, you know, five thousand

0:10:53.640 --> 0:10:57.320
<v Speaker 1>years ago, seven thousand years ago, could have carried this

0:10:57.360 --> 0:11:01.160
<v Speaker 1>out successfully seemed to fly in the face of logic.

0:11:01.720 --> 0:11:06.280
<v Speaker 1>And what Squire did is he presented, um, this this skult.

0:11:06.360 --> 0:11:08.840
<v Speaker 1>Paul Broca, who was a French or was a French

0:11:08.880 --> 0:11:12.120
<v Speaker 1>neurosurgeon and also the person for whom Broca's area in

0:11:12.120 --> 0:11:16.199
<v Speaker 1>the brain is named for, and he corroborated Squire's discovery

0:11:16.400 --> 0:11:21.319
<v Speaker 1>and said, yes, this is intentional. This looks like neurosurgery. Um.

0:11:21.360 --> 0:11:26.240
<v Speaker 1>But Broca thought it was done for primitive reasons, again

0:11:26.400 --> 0:11:31.240
<v Speaker 1>releasing the demons the ghost of the mind. And Squire said, no,

0:11:31.760 --> 0:11:35.560
<v Speaker 1>I don't think so. And he was the first, I

0:11:35.600 --> 0:11:37.960
<v Speaker 1>believe at that time, to come out and say I

0:11:38.000 --> 0:11:43.280
<v Speaker 1>think that it has more to do with perhaps combat. Yes. Um.

0:11:43.440 --> 0:11:46.079
<v Speaker 1>I should also point out that Broke also thought that

0:11:46.160 --> 0:11:49.560
<v Speaker 1>it was done almost exclusively on children. Yeah, this is

0:11:49.960 --> 0:11:53.080
<v Speaker 1>which he collaborated by saying, they look, I used a

0:11:53.120 --> 0:11:57.080
<v Speaker 1>glass instrument to to to gouge holes in the corpses

0:11:57.120 --> 0:12:00.200
<v Speaker 1>of children and adult dead adults, and I found that

0:12:00.280 --> 0:12:03.680
<v Speaker 1>it was far the far faster procedure with the child.

0:12:04.280 --> 0:12:07.360
<v Speaker 1>And therefore he concluded that it was used exclusively on children,

0:12:07.920 --> 0:12:11.600
<v Speaker 1>which was his experience with his instruments. Right. So it's

0:12:11.640 --> 0:12:15.320
<v Speaker 1>not a great way to sort of test out that hypothesis,

0:12:15.720 --> 0:12:18.800
<v Speaker 1>but that's what he came to. Um. In the meantime,

0:12:19.000 --> 0:12:22.000
<v Speaker 1>you have things like inc and pots that are showing

0:12:22.080 --> 0:12:26.640
<v Speaker 1>up depicting trepen nation, further evidence that this was happening. Um,

0:12:26.679 --> 0:12:29.360
<v Speaker 1>you have a survey of ancient inc and skulls showing

0:12:29.440 --> 0:12:34.040
<v Speaker 1>that more males than females had trepennation holes, probably because

0:12:34.160 --> 0:12:37.920
<v Speaker 1>most warriors were men. And in addition, the majority of

0:12:38.080 --> 0:12:41.480
<v Speaker 1>man made holes in the skull would occur on the

0:12:41.559 --> 0:12:44.280
<v Speaker 1>left side of the school. And the idea is that

0:12:44.600 --> 0:12:48.360
<v Speaker 1>right handed assailants, of which we know there are more of, Um,

0:12:48.440 --> 0:12:52.240
<v Speaker 1>those the blows of those assailants would land on the

0:12:52.320 --> 0:12:54.160
<v Speaker 1>left side of the school. We're talking about from a

0:12:54.200 --> 0:12:58.320
<v Speaker 1>club sword, a slingshot, Um, so that's sort of more

0:12:58.400 --> 0:13:02.600
<v Speaker 1>evidence that in this case, in the Incan's case, this

0:13:02.679 --> 0:13:06.440
<v Speaker 1>kind of trepidation was more of an e er procedure. Really, right,

0:13:06.480 --> 0:13:09.360
<v Speaker 1>you have individuals who sustained massive damage to the head.

0:13:09.360 --> 0:13:13.400
<v Speaker 1>They've essentially sustained brain trauma, and so the surgical procedure

0:13:13.440 --> 0:13:16.440
<v Speaker 1>of the day was to try to relieve that pressure. Yes,

0:13:16.520 --> 0:13:18.760
<v Speaker 1>so let's let's give it a look, see and try

0:13:18.800 --> 0:13:22.200
<v Speaker 1>to imagine what this might be. You're an Incan warrior. Yeah,

0:13:22.240 --> 0:13:25.040
<v Speaker 1>I'm just stumbled in from the battlefield. I took a

0:13:25.080 --> 0:13:28.560
<v Speaker 1>club blow to the head. I'm in pain, I'm bleeding.

0:13:29.000 --> 0:13:31.200
<v Speaker 1>What can you do for me? Doc? Ah, Well, I

0:13:31.240 --> 0:13:33.080
<v Speaker 1>see that you might have some shards of your own

0:13:33.120 --> 0:13:35.040
<v Speaker 1>skull in your brain. We've got to pick this out.

0:13:35.960 --> 0:13:40.640
<v Speaker 1>Let's clamp your head between minknees, pour some coconut juice

0:13:40.679 --> 0:13:44.199
<v Speaker 1>on your scalp, and then we've got some freshly cut

0:13:44.280 --> 0:13:46.680
<v Speaker 1>leaves that we can just put on this wound to

0:13:46.880 --> 0:13:49.920
<v Speaker 1>dull the pain. Oh, okay, that would be coca leaves.

0:13:50.120 --> 0:13:53.040
<v Speaker 1>Coco leaves exactly. And maybe you want to even have

0:13:53.080 --> 0:13:55.480
<v Speaker 1>a little bit of our homemade alcohol because things are

0:13:55.520 --> 0:13:57.640
<v Speaker 1>going to get I might need that crazy. Maybe some

0:13:57.720 --> 0:14:01.040
<v Speaker 1>tobacco as well, even yes, some tobacco. I'm going to

0:14:01.120 --> 0:14:03.960
<v Speaker 1>take the sharp object. It could be perhaps a tooth

0:14:04.400 --> 0:14:07.800
<v Speaker 1>from the animal. Good. Good, sounds good. Okay, I'm gonna

0:14:07.800 --> 0:14:10.600
<v Speaker 1>cut into your skull and I'm gonna groove it around

0:14:10.679 --> 0:14:13.840
<v Speaker 1>and around this fracture you have deeper into your skull

0:14:14.640 --> 0:14:17.080
<v Speaker 1>and uh, you have a little bit more of those

0:14:17.120 --> 0:14:19.640
<v Speaker 1>cocoa leaves, by the way, and then you're going to

0:14:19.720 --> 0:14:23.280
<v Speaker 1>feel this kind of sucking feeling when this plug of

0:14:23.360 --> 0:14:27.040
<v Speaker 1>bone comes off of your brain, so rather your skull,

0:14:27.080 --> 0:14:29.200
<v Speaker 1>because it's kind of like my brain is sealed in

0:14:29.240 --> 0:14:31.680
<v Speaker 1>a in a tupperware, right, and you have just drilled

0:14:31.720 --> 0:14:35.360
<v Speaker 1>through that type of ware with your animal tooth. Yes,

0:14:35.520 --> 0:14:38.040
<v Speaker 1>but it's not over yet because I have these Greek

0:14:38.080 --> 0:14:42.400
<v Speaker 1>forceps that I've fashioned out of bamboo, and now I'm

0:14:42.440 --> 0:14:44.800
<v Speaker 1>just gonna kind of pick around the wound, wash it

0:14:44.840 --> 0:14:46.640
<v Speaker 1>out with a little bit more coconut milk, and take

0:14:46.680 --> 0:14:49.880
<v Speaker 1>out any other sort of splinters because you know you

0:14:49.920 --> 0:14:53.600
<v Speaker 1>don't want that. And I'm gonna dress it with leaves,

0:14:53.880 --> 0:14:57.680
<v Speaker 1>a plaster of pepper, lime and beetlenut. Excellent. Now, is

0:14:57.680 --> 0:14:59.240
<v Speaker 1>there any way you could you could sew things up

0:14:59.280 --> 0:15:01.520
<v Speaker 1>there as well. Oh yeah, that's a good point. That's

0:15:01.600 --> 0:15:03.840
<v Speaker 1>we should really sew you up with some bat bones

0:15:03.880 --> 0:15:06.720
<v Speaker 1>and banana fibers. Good, good before putting that dressing on.

0:15:06.800 --> 0:15:09.400
<v Speaker 1>Thanks for reminding me, because that could have been really bad. Yeah,

0:15:09.400 --> 0:15:11.000
<v Speaker 1>I would have had to come back and you know,

0:15:11.000 --> 0:15:13.040
<v Speaker 1>and then that's two visits and I don't know how

0:15:13.080 --> 0:15:17.160
<v Speaker 1>my incot insurance covers those, uh, those postop visits. Also

0:15:17.320 --> 0:15:20.400
<v Speaker 1>count yourself lucky because if this were happening in the future,

0:15:20.520 --> 0:15:23.000
<v Speaker 1>in like the nineteenth century, you might be toast because

0:15:23.120 --> 0:15:26.720
<v Speaker 1>you know that coconut juice super good for keeping bacteria out,

0:15:26.760 --> 0:15:29.000
<v Speaker 1>and it turns out that that's a real killer. Yeah,

0:15:29.080 --> 0:15:30.920
<v Speaker 1>this is this touches on the really one of the

0:15:31.000 --> 0:15:33.120
<v Speaker 1>really interesting parts about it, especially when you're looking at

0:15:33.120 --> 0:15:36.040
<v Speaker 1>it from Squire's point of view in his time, because again,

0:15:36.400 --> 0:15:40.960
<v Speaker 1>Western society had pretty much abandoned trepid nation. Because despite

0:15:41.480 --> 0:15:45.320
<v Speaker 1>improving tools, you know, moving from more primitive instruments to

0:15:45.320 --> 0:15:49.360
<v Speaker 1>two instruments of metal and devices and clamps and whatnot

0:15:49.400 --> 0:15:51.080
<v Speaker 1>to put on top of the head like you see

0:15:51.080 --> 0:15:54.520
<v Speaker 1>in the woodcuts. Um, despite all these advancements, there was

0:15:54.600 --> 0:15:58.840
<v Speaker 1>still pretty high mortality rate for individuals sustaining any kind

0:15:58.840 --> 0:16:01.760
<v Speaker 1>of nursery on up into to uh the eighteen seventies

0:16:02.320 --> 0:16:05.400
<v Speaker 1>when a survey found that it's many as seventy of

0:16:05.480 --> 0:16:10.840
<v Speaker 1>neurosurgical patients died now mostly from infect mostly from infection

0:16:10.880 --> 0:16:13.360
<v Speaker 1>because there's one thing to to dig around in there,

0:16:13.400 --> 0:16:15.800
<v Speaker 1>but then everything has to heal and and it's very

0:16:15.840 --> 0:16:19.280
<v Speaker 1>susceptible to infection. Now you compare this to New Guinea

0:16:19.480 --> 0:16:23.120
<v Speaker 1>tribes and uh, you see just thirty percent of those

0:16:23.160 --> 0:16:27.000
<v Speaker 1>patients died. So obviously there's something here to keeping the

0:16:27.120 --> 0:16:30.160
<v Speaker 1>wound infection free. And you think about this too, even

0:16:30.240 --> 0:16:34.960
<v Speaker 1>like with childbirth fatalities, once things were sterilized and a

0:16:35.000 --> 0:16:38.080
<v Speaker 1>good practice was put into place that really got people

0:16:38.120 --> 0:16:42.320
<v Speaker 1>over the hump of of the actual procedure itself and

0:16:43.280 --> 0:16:45.600
<v Speaker 1>you know, help them to heal and And here's a

0:16:45.640 --> 0:16:49.480
<v Speaker 1>great example of Wow, I um survived this Trepi nation,

0:16:49.640 --> 0:16:53.960
<v Speaker 1>but now I might pass away from an infected wound. Yeah.

0:16:54.280 --> 0:16:56.040
<v Speaker 1>So it's kind of a champion of the little man

0:16:56.080 --> 0:16:58.800
<v Speaker 1>in a sense, because the squire ended up end up

0:16:58.800 --> 0:17:03.200
<v Speaker 1>being the victor in this uh in this argument was indicated. Yeah,

0:17:03.400 --> 0:17:07.840
<v Speaker 1>this self taught archaeologist won over the esteemed French neurologists

0:17:07.840 --> 0:17:10.159
<v Speaker 1>broke up. So kind of like that, and it's a

0:17:10.240 --> 0:17:14.120
<v Speaker 1>champion for these the so called primitive societies that were

0:17:14.160 --> 0:17:18.160
<v Speaker 1>looked down on. H Suddenly people had to realize, Hey,

0:17:18.200 --> 0:17:22.240
<v Speaker 1>the ancient Incans, they knew what they were doing indeed,

0:17:22.680 --> 0:17:24.280
<v Speaker 1>and they were doing it in a way that was

0:17:24.359 --> 0:17:28.479
<v Speaker 1>more successful than they're more modern counterparts. All Right, we're

0:17:28.480 --> 0:17:31.240
<v Speaker 1>gonna take a quick break. Uh So when we get back,

0:17:31.280 --> 0:17:33.880
<v Speaker 1>we're going to talk about Amanda Fielding, who is best

0:17:33.920 --> 0:17:45.200
<v Speaker 1>known for performing her own trep nation. Alright, we're back,

0:17:45.320 --> 0:17:47.200
<v Speaker 1>and you know, it's easy to think at this point

0:17:47.240 --> 0:17:51.000
<v Speaker 1>in the podcast, well, all right, we've discussed some of

0:17:51.040 --> 0:17:54.040
<v Speaker 1>the ideas about wine. People would drill a hole in

0:17:54.040 --> 0:17:57.800
<v Speaker 1>the head wine tref nation was practiced wine wine is

0:17:57.840 --> 0:17:59.960
<v Speaker 1>still practiced today, and you might think, well, case club,

0:18:00.200 --> 0:18:02.320
<v Speaker 1>we've sort of we've sort of figured it out. There

0:18:02.320 --> 0:18:05.280
<v Speaker 1>are a few cases in which we need to apply

0:18:05.400 --> 0:18:08.760
<v Speaker 1>this procedure in order to deal with some sort of

0:18:09.080 --> 0:18:11.680
<v Speaker 1>injury to the to the skull in some sort of

0:18:11.720 --> 0:18:15.160
<v Speaker 1>brain trauma or some sort of neurosurgery that requires access

0:18:15.200 --> 0:18:19.439
<v Speaker 1>to the brain. There couldn't be any wacky or pseudo

0:18:19.480 --> 0:18:24.520
<v Speaker 1>scientific or controversial reason to drill a hole in your head. Well, miss,

0:18:27.320 --> 0:18:30.920
<v Speaker 1>you decided to drill a hole in your head. Maybe

0:18:30.960 --> 0:18:35.159
<v Speaker 1>you're trying to widen your consciousness. Yes, is that the

0:18:35.160 --> 0:18:38.399
<v Speaker 1>wacky reason? I think so? Yeah, pretty much. Yeah, the

0:18:38.480 --> 0:18:42.400
<v Speaker 1>idea of performing trepination generally on yourself because it's hard

0:18:42.400 --> 0:18:45.320
<v Speaker 1>to find somebody to do it for you if your

0:18:45.359 --> 0:18:49.040
<v Speaker 1>whole goal is to expand human consciousness. Yeah, if it's

0:18:49.040 --> 0:18:52.320
<v Speaker 1>not an emergency medical situation, most likely the person the

0:18:52.359 --> 0:18:54.760
<v Speaker 1>surgeon is not going to perform, right. That person agreeing

0:18:54.760 --> 0:18:57.359
<v Speaker 1>to do it is probably not an actual doctor, and

0:18:57.440 --> 0:19:00.600
<v Speaker 1>you're probably not in a hospital. Yeah, you should check

0:19:00.640 --> 0:19:04.239
<v Speaker 1>references and look around. But yeah, I mean we are

0:19:04.280 --> 0:19:09.080
<v Speaker 1>talking about Amanda fil Fielding, who documented her own trepid

0:19:09.160 --> 0:19:12.560
<v Speaker 1>nation and this is a nineteen seventy film called Heartbeat

0:19:12.600 --> 0:19:15.480
<v Speaker 1>in the Brain. She is now seventy one years old

0:19:15.520 --> 0:19:17.879
<v Speaker 1>and is the director of the Beckley Foundation, a trust

0:19:17.920 --> 0:19:20.439
<v Speaker 1>that for over a decade has been carrying out research

0:19:20.480 --> 0:19:24.240
<v Speaker 1>into consciousness, including the use of LSD and other psychoactive substances.

0:19:24.720 --> 0:19:28.000
<v Speaker 1>She also ran for British Parliament twice on the platform

0:19:28.080 --> 0:19:33.119
<v Speaker 1>of trepid nation and these great posters but she has

0:19:33.119 --> 0:19:37.359
<v Speaker 1>that shows her with a bird on her shoulder looking

0:19:37.520 --> 0:19:39.800
<v Speaker 1>out in the distance, and then it says trepa nation

0:19:40.720 --> 0:19:44.160
<v Speaker 1>for the national health. You know, that's an interesting way

0:19:44.200 --> 0:19:46.800
<v Speaker 1>to sell trepid nation, just with sort of an abstract

0:19:46.880 --> 0:19:50.800
<v Speaker 1>bird like because I can easily imagine, and not to

0:19:51.800 --> 0:19:54.520
<v Speaker 1>poke fun at or anything, but I can imagine her

0:19:54.560 --> 0:19:58.439
<v Speaker 1>bringing up this. This is being her number one focus

0:19:58.520 --> 0:20:01.520
<v Speaker 1>point for the campaign, and in her campaign people saying, well,

0:20:01.520 --> 0:20:03.639
<v Speaker 1>we need to present that in a way that's a

0:20:03.640 --> 0:20:08.040
<v Speaker 1>little maybe a little less on the nose. Uh, maybe

0:20:08.080 --> 0:20:10.560
<v Speaker 1>no images of anyone actually drilling into their head if

0:20:10.600 --> 0:20:13.119
<v Speaker 1>we're saying more just a bird staring off in the distance.

0:20:13.200 --> 0:20:16.520
<v Speaker 1>I feel like she took both tacks though, because I

0:20:16.520 --> 0:20:19.000
<v Speaker 1>think there's another one around him, which it's the sort

0:20:19.040 --> 0:20:21.960
<v Speaker 1>of iconic image from the documentary which her head is

0:20:21.960 --> 0:20:24.399
<v Speaker 1>wrapped up and looking in the mirror. She look in

0:20:24.440 --> 0:20:27.280
<v Speaker 1>the mirror and there's some blood going down her face. Um,

0:20:27.359 --> 0:20:30.000
<v Speaker 1>so maybe she was testing out, you know, a b

0:20:30.640 --> 0:20:34.200
<v Speaker 1>situations there that she was advocating trepidation. She was saying,

0:20:34.640 --> 0:20:37.240
<v Speaker 1>we would be better off if we if we all

0:20:37.280 --> 0:20:39.880
<v Speaker 1>did this. Before we go into the wise of why

0:20:39.920 --> 0:20:41.520
<v Speaker 1>she did it, let's talk about how she did it,

0:20:41.760 --> 0:20:45.040
<v Speaker 1>because again she's filming herself. She's in the mirror. She

0:20:45.280 --> 0:20:48.240
<v Speaker 1>said in an interview with Vice magazine. I was obviously

0:20:48.320 --> 0:20:51.080
<v Speaker 1>very cautious and prepared myself very carefully. I used an

0:20:51.119 --> 0:20:53.840
<v Speaker 1>electric drill with a flat bottom and a foot pedal

0:20:54.240 --> 0:20:56.719
<v Speaker 1>and tested the drill head on the membranes of my

0:20:56.840 --> 0:20:59.800
<v Speaker 1>hands to see if it would damage the skin. The

0:21:00.040 --> 0:21:03.280
<v Speaker 1>old thing was carefully prepared. But more than anything, I

0:21:03.359 --> 0:21:06.440
<v Speaker 1>prepared myself psychologically. It's the last thing you want to do.

0:21:07.359 --> 0:21:10.240
<v Speaker 1>After I'd performed the procedure, I wrapped up my head

0:21:10.280 --> 0:21:12.920
<v Speaker 1>with a scarf, had a stake to replace iron from

0:21:12.920 --> 0:21:16.320
<v Speaker 1>the lost blood. I think almost a point by the way,

0:21:16.480 --> 0:21:20.760
<v Speaker 1>and and went to a party. It doesn't set you

0:21:20.800 --> 0:21:24.320
<v Speaker 1>back at all. It doesn't incapacity incapacitate you. It is

0:21:24.400 --> 0:21:26.679
<v Speaker 1>just a half hour operation. But in no way am

0:21:26.720 --> 0:21:30.160
<v Speaker 1>I advocating the idea of self trepnation. It should always

0:21:30.200 --> 0:21:33.800
<v Speaker 1>be carried out by members of a medical profession. So,

0:21:34.040 --> 0:21:36.520
<v Speaker 1>and that's key here again. If anyone reads this and

0:21:37.000 --> 0:21:39.280
<v Speaker 1>here's this and thinks I want to that sounds interesting,

0:21:39.280 --> 0:21:42.440
<v Speaker 1>I'd like to give that a go. The the world's

0:21:42.640 --> 0:21:45.880
<v Speaker 1>foremost trepennation advocate says, do not do this at home,

0:21:45.960 --> 0:21:48.359
<v Speaker 1>and only that. She says that, yes, she had a

0:21:48.440 --> 0:21:51.640
<v Speaker 1>change in dream pattern. She says her dreams became less anxious,

0:21:52.280 --> 0:21:55.200
<v Speaker 1>But she says, could all of that be described as

0:21:55.200 --> 0:21:58.040
<v Speaker 1>a placebo? There is, of course that possibility, and I

0:21:58.080 --> 0:22:01.879
<v Speaker 1>am very conscious of that. So she acknowledges, Yeah, I

0:22:01.960 --> 0:22:04.160
<v Speaker 1>drolled a hole in my head. I felt better for it.

0:22:04.200 --> 0:22:07.400
<v Speaker 1>But you know what, I'm aware of the placebo effect

0:22:07.440 --> 0:22:10.199
<v Speaker 1>and this could perhaps be just a psychological state for me.

0:22:10.840 --> 0:22:13.040
<v Speaker 1>So let's talk about why she did this to herself. Well,

0:22:13.080 --> 0:22:15.600
<v Speaker 1>for starters, she was the pupil of Bart Hugos, a

0:22:15.880 --> 0:22:18.320
<v Speaker 1>Dutchman who in the nineteen sixty five carried out his

0:22:18.440 --> 0:22:23.000
<v Speaker 1>own self trepi nation in order to expand his consciousness

0:22:23.160 --> 0:22:25.960
<v Speaker 1>and uh and was a huge advocate of it himself,

0:22:26.480 --> 0:22:29.640
<v Speaker 1>claiming that it was a way to essentially be high

0:22:29.640 --> 0:22:32.040
<v Speaker 1>all the time. Yeah, and it's side note too, he

0:22:32.160 --> 0:22:37.239
<v Speaker 1>named his daughter Maria Juana marijuana. Well I read that

0:22:37.240 --> 0:22:39.680
<v Speaker 1>that's he was actually kicked out of medical school because

0:22:39.680 --> 0:22:42.639
<v Speaker 1>he was a huge marijuana advocate. Yes, yeah, so I

0:22:42.680 --> 0:22:44.560
<v Speaker 1>just thought there's an interesting side note since we just

0:22:44.600 --> 0:22:47.040
<v Speaker 1>did an episode on names and how they have these

0:22:47.040 --> 0:22:51.480
<v Speaker 1>sort of self fulfilling prophecies sometimes. Anyway, I digress, Yeah,

0:22:51.520 --> 0:22:54.440
<v Speaker 1>a very interesting character. He came up with a concept

0:22:54.480 --> 0:22:57.720
<v Speaker 1>called brain blood volume, and this is this idea that

0:22:57.760 --> 0:23:02.720
<v Speaker 1>trepanning allows the full heart beat to express itself. And

0:23:03.119 --> 0:23:05.439
<v Speaker 1>Fielding says, hey, when a baby is born, the top

0:23:05.520 --> 0:23:07.399
<v Speaker 1>of the skull is really soft and flexible, and you

0:23:07.440 --> 0:23:10.960
<v Speaker 1>have a fontanelle closing and then the skull bones closed.

0:23:10.960 --> 0:23:13.920
<v Speaker 1>And she says this inhibits the full pulsation of the heartbeat,

0:23:14.000 --> 0:23:16.960
<v Speaker 1>so it's denied its full expression of the brain, so

0:23:17.000 --> 0:23:20.199
<v Speaker 1>to speak. That loss of pulse pressure results in a

0:23:20.280 --> 0:23:22.680
<v Speaker 1>change of ratio between the two fluids and the brain

0:23:22.800 --> 0:23:26.000
<v Speaker 1>blood and cerebral spinal fluid, which is important and won't

0:23:26.040 --> 0:23:28.480
<v Speaker 1>get to that in a moment. She says, it is

0:23:28.520 --> 0:23:31.240
<v Speaker 1>blood that feeds the brain cells with what they need,

0:23:31.280 --> 0:23:34.200
<v Speaker 1>such as glucose and oxygen. That's cerebral spinal fluid removes

0:23:34.240 --> 0:23:37.359
<v Speaker 1>some of the toxic molecules. So she's saying that trepre

0:23:37.440 --> 0:23:40.960
<v Speaker 1>nation essentially works by restoring the full pulse pressure of

0:23:41.000 --> 0:23:46.320
<v Speaker 1>the heartbeat. And she has been doing some research lately

0:23:47.160 --> 0:23:51.679
<v Speaker 1>about this as it relates to Alzheimer's. But before we

0:23:51.720 --> 0:23:53.520
<v Speaker 1>get into that, I thought it would be helpful for

0:23:53.600 --> 0:23:56.119
<v Speaker 1>us to kind of give a call back to a

0:23:56.160 --> 0:23:59.960
<v Speaker 1>past episode called The Night Janitor, in which we talk

0:24:00.000 --> 0:24:03.320
<v Speaker 1>talked about the glymphatic system. Yeah, we're talking about the

0:24:03.359 --> 0:24:06.880
<v Speaker 1>glymphatic system or the glymphatic clearance pathway. It's a functional

0:24:07.119 --> 0:24:11.960
<v Speaker 1>waste clearance pathway in the mammalian central nervous system. And

0:24:13.040 --> 0:24:16.520
<v Speaker 1>this discovery really lands the feat of Danish biologists making

0:24:16.840 --> 0:24:20.520
<v Speaker 1>nater guard um. She was leading research into sleep function

0:24:20.560 --> 0:24:23.359
<v Speaker 1>at the University of Rochester's Medical school, and uh, she

0:24:23.400 --> 0:24:26.119
<v Speaker 1>didn't think everything was really stacking up and making sense

0:24:26.680 --> 0:24:29.040
<v Speaker 1>that I figured that the brain is too busy to

0:24:29.119 --> 0:24:32.960
<v Speaker 1>recycle all this energy, that there's essentially a waste disposal

0:24:33.000 --> 0:24:35.240
<v Speaker 1>problem with the human brain. Yeah, because she was looking

0:24:35.280 --> 0:24:40.679
<v Speaker 1>at the lymphatic system. So muscles um create toxic by products, right,

0:24:40.680 --> 0:24:42.280
<v Speaker 1>and those build up and then they're ushered out by

0:24:42.280 --> 0:24:44.520
<v Speaker 1>the lymphatic system. So she was thinking, I don't think

0:24:44.560 --> 0:24:47.119
<v Speaker 1>the brain can't be doing that. The brain is so

0:24:47.280 --> 0:24:49.800
<v Speaker 1>active during the day. Maybe we can look at this

0:24:49.920 --> 0:24:52.359
<v Speaker 1>at night and see what's going on in terms of

0:24:52.440 --> 0:24:56.320
<v Speaker 1>waste removal. Yeah, she suspected that the brain shared a

0:24:56.800 --> 0:25:00.040
<v Speaker 1>similar system that the muscles had, and the in o

0:25:00.119 --> 0:25:03.840
<v Speaker 1>lymphatic system offered um but instead of it's predicated on

0:25:04.160 --> 0:25:08.040
<v Speaker 1>cerebro spinal fluid in what she called the glymphatic system

0:25:08.560 --> 0:25:12.400
<v Speaker 1>with a nod to the brains glial cells, which maintain

0:25:12.680 --> 0:25:16.919
<v Speaker 1>homeostasis and protect neurons. So what she did she and

0:25:16.960 --> 0:25:21.360
<v Speaker 1>her team injected anesthetized mice with fluorescent tracers into their

0:25:21.400 --> 0:25:24.640
<v Speaker 1>cerebro spinal fluids. So this allowed them to track where

0:25:24.640 --> 0:25:27.320
<v Speaker 1>the fluid was traveling in their bodies, in their brains,

0:25:27.640 --> 0:25:30.960
<v Speaker 1>and during the mice's waking hours, that fluid barely made

0:25:30.960 --> 0:25:35.520
<v Speaker 1>it into the brain, but once sleep was induced, the

0:25:35.560 --> 0:25:38.800
<v Speaker 1>brain cells of the mice actually shrunk, and that made

0:25:38.960 --> 0:25:42.520
<v Speaker 1>way for a flood of the cerebro spinal fluid, essentially

0:25:42.560 --> 0:25:46.240
<v Speaker 1>hosing down the brain of waste with the proteins and

0:25:46.320 --> 0:25:51.399
<v Speaker 1>that the toxic byproducts and ushering them out. And here's

0:25:51.440 --> 0:25:55.400
<v Speaker 1>the weird thing. Are not weird, but very very interesting,

0:25:56.000 --> 0:25:59.679
<v Speaker 1>and humans with dementia in Alzheimer's, there's an excess of

0:25:59.720 --> 0:26:05.520
<v Speaker 1>the rains toxic byproduct beta amyloid. So that is giving

0:26:05.560 --> 0:26:09.399
<v Speaker 1>researchers a really big reason to look into cerebro spinal

0:26:09.440 --> 0:26:13.240
<v Speaker 1>fluid and see how it takes away these these byproducts.

0:26:13.240 --> 0:26:15.080
<v Speaker 1>Because the idea is that if there is a build

0:26:15.160 --> 0:26:18.240
<v Speaker 1>up well that can cause disease, it's kind of like plaque,

0:26:18.240 --> 0:26:21.680
<v Speaker 1>It's like brain plaque. So now you have Russian neuro

0:26:22.119 --> 0:26:27.119
<v Speaker 1>physiologist Uri muson Nico who believes that tref nation could

0:26:27.160 --> 0:26:30.000
<v Speaker 1>act as a kind of release valve and allow better

0:26:30.080 --> 0:26:33.439
<v Speaker 1>circulation of the cerebro spinal fluid. And he says that

0:26:33.480 --> 0:26:35.560
<v Speaker 1>as we age the proteins in the brain hard in

0:26:35.680 --> 0:26:38.359
<v Speaker 1>preventing this system from working as it should, and as

0:26:38.400 --> 0:26:40.840
<v Speaker 1>a result, the flow of both blood and cerebro spinal

0:26:40.880 --> 0:26:44.280
<v Speaker 1>fluid is reduced and impairs the delivery of oxygen and

0:26:44.359 --> 0:26:48.360
<v Speaker 1>nutrients as well as a removal of waste. Now, if

0:26:48.400 --> 0:26:53.080
<v Speaker 1>I'm understanding this, right Fielding is actually working with that

0:26:53.160 --> 0:26:58.160
<v Speaker 1>Russian researcher and has the same beliefs about this. And

0:26:59.359 --> 0:27:02.840
<v Speaker 1>you know, almost didn't want to even point these two

0:27:02.920 --> 0:27:06.840
<v Speaker 1>things together with the night janitor that we discussed in

0:27:06.880 --> 0:27:10.800
<v Speaker 1>the cerebrospinal fluid being attached to um the build up

0:27:11.040 --> 0:27:17.000
<v Speaker 1>of proteins and disease. But it's so interesting that this

0:27:17.200 --> 0:27:20.840
<v Speaker 1>trepin nation aspect of it would come into play. Yeah,

0:27:21.160 --> 0:27:23.879
<v Speaker 1>we were talking about this earlier, you know, hesitant to

0:27:24.040 --> 0:27:28.160
<v Speaker 1>draw any lines between um, such an extreme activity as

0:27:28.200 --> 0:27:32.240
<v Speaker 1>a self trepination or even advocating self trefination and an

0:27:32.280 --> 0:27:35.680
<v Speaker 1>actual grounded science. But the way I like to look

0:27:35.720 --> 0:27:39.400
<v Speaker 1>at it is, this is an extreme view, and it's

0:27:39.440 --> 0:27:41.399
<v Speaker 1>kind of like taking the train to the end of

0:27:41.400 --> 0:27:43.399
<v Speaker 1>the line. Not everybody takes the train to the end

0:27:43.440 --> 0:27:46.639
<v Speaker 1>of the line of the tracks maybe uh maybe you know,

0:27:46.960 --> 0:27:51.359
<v Speaker 1>completely ironed out with with real science, but you can

0:27:51.560 --> 0:27:53.560
<v Speaker 1>follow the tracks. It's too far, you can go a

0:27:53.600 --> 0:27:55.960
<v Speaker 1>little too far down the line. And even someone in

0:27:55.960 --> 0:27:59.520
<v Speaker 1>an extreme position, that extreme position is going to be

0:27:59.560 --> 0:28:02.199
<v Speaker 1>in paying old with with some truths a lot of

0:28:02.200 --> 0:28:07.080
<v Speaker 1>the time. And so who knows where this exactly pans

0:28:07.080 --> 0:28:10.720
<v Speaker 1>out in the end? Yes, well, of course research is needed,

0:28:10.800 --> 0:28:14.840
<v Speaker 1>right and then the problem is hiding research funding for trefination,

0:28:15.640 --> 0:28:18.040
<v Speaker 1>and um, you know, I know that they have looked

0:28:18.080 --> 0:28:21.240
<v Speaker 1>at Alzheimer's patients before, and people who have had head

0:28:21.280 --> 0:28:24.160
<v Speaker 1>traumas and then had trepronation, and they have seen that

0:28:24.680 --> 0:28:29.760
<v Speaker 1>when they are trepinated, that the that that blood flow increases,

0:28:31.040 --> 0:28:34.640
<v Speaker 1>and then when they replace that bone fragment or they

0:28:34.680 --> 0:28:37.359
<v Speaker 1>seal it up that it reduces. So, yes, that's true,

0:28:37.800 --> 0:28:40.720
<v Speaker 1>but there's not enough research here to say, ah, yes,

0:28:40.840 --> 0:28:44.520
<v Speaker 1>this is the thing that will cure Alzheimer's or dementia.

0:28:44.680 --> 0:28:47.600
<v Speaker 1>And in fact, I think the real star of this

0:28:47.720 --> 0:28:51.840
<v Speaker 1>story is crebro spinal fluid, the fact that this is

0:28:51.880 --> 0:28:54.160
<v Speaker 1>the stuff that hosts down the works in your brain

0:28:54.280 --> 0:28:56.600
<v Speaker 1>and takes out the toxic byproducts. And then the second

0:28:56.600 --> 0:29:00.240
<v Speaker 1>real story is that happens when you sleep, So you

0:29:00.280 --> 0:29:02.440
<v Speaker 1>have to have enough sleep in order for you to

0:29:02.480 --> 0:29:05.160
<v Speaker 1>get enough of that in your brain to take away

0:29:05.200 --> 0:29:08.080
<v Speaker 1>these toxic byproducts. Now, where this where my brain goes

0:29:08.120 --> 0:29:10.640
<v Speaker 1>in all of this is is not so much imagining

0:29:10.640 --> 0:29:12.760
<v Speaker 1>a future where everybody goes to the doctor and has

0:29:12.800 --> 0:29:15.800
<v Speaker 1>a whole drilled in their head. But but where this

0:29:15.880 --> 0:29:19.200
<v Speaker 1>might lead as we understand more about the subrospinal fluid,

0:29:19.640 --> 0:29:22.160
<v Speaker 1>do we reach a point where there is some other

0:29:22.280 --> 0:29:25.840
<v Speaker 1>kind of trans human fix in place to sort of

0:29:25.840 --> 0:29:30.640
<v Speaker 1>tweak our evolved form for operable performance, Like maybe it

0:29:30.720 --> 0:29:35.480
<v Speaker 1>ends up being something that's achieved with nanotechnology. That's true,

0:29:35.640 --> 0:29:38.160
<v Speaker 1>that's the possibility, right, Or is there a way to

0:29:38.240 --> 0:29:44.080
<v Speaker 1>induce sell shrinkage in your brain without any adverse side effects. Um,

0:29:44.320 --> 0:29:48.440
<v Speaker 1>that would allow an easier path for the fluid. I

0:29:48.440 --> 0:29:51.200
<v Speaker 1>don't know. These are all really interesting questions, UM, but

0:29:51.280 --> 0:29:54.800
<v Speaker 1>I thought what was most interesting, UM in terms of

0:29:55.240 --> 0:30:00.240
<v Speaker 1>Amanda Fielding, is that she's not entirely on board word

0:30:00.440 --> 0:30:03.320
<v Speaker 1>with the trepidation. Like she's definitely interested in pursuing it

0:30:03.480 --> 0:30:09.040
<v Speaker 1>as a path to understanding consciousness and disease, but she says,

0:30:09.640 --> 0:30:11.959
<v Speaker 1>in response to the question by advice, would you be

0:30:12.040 --> 0:30:14.760
<v Speaker 1>doing the research even if you weren't trepanned? She says, yes,

0:30:14.800 --> 0:30:17.160
<v Speaker 1>I think so. But I suppose that my personal experience

0:30:17.160 --> 0:30:20.120
<v Speaker 1>of getting trepanned, which I of course would not put

0:30:20.200 --> 0:30:22.760
<v Speaker 1>total faith in, gave me the feeling that it's worthy

0:30:22.800 --> 0:30:28.600
<v Speaker 1>of research. So again here she is sort of she's saying, yeah,

0:30:28.640 --> 0:30:30.640
<v Speaker 1>it's giving me a perspective that I want to pursue,

0:30:30.800 --> 0:30:33.600
<v Speaker 1>but I'm not sure that it's the way to go.

0:30:34.400 --> 0:30:37.280
<v Speaker 1>M Do I think is helpful? Yeah? Yeah, she seems

0:30:38.960 --> 0:30:43.200
<v Speaker 1>for a person that that did undergo self trepination, you know,

0:30:43.320 --> 0:30:45.840
<v Speaker 1>she's she's seemed to be a very self conscious and

0:30:45.960 --> 0:30:49.680
<v Speaker 1>very grounded individual. So there you have trepidation, which, in

0:30:49.680 --> 0:30:52.240
<v Speaker 1>a very loose sense is is kind of like loosening

0:30:52.280 --> 0:30:56.720
<v Speaker 1>the belt on your brains pants. Yeah, eating a big meal,

0:30:57.160 --> 0:30:59.160
<v Speaker 1>You've been thinking a lot of thoughts that meal, and

0:30:59.160 --> 0:31:02.800
<v Speaker 1>then pop, Yeah, a little bit more room, I suppose,

0:31:02.880 --> 0:31:05.240
<v Speaker 1>a little bit more room to expand. Yeah, that's the

0:31:05.280 --> 0:31:08.680
<v Speaker 1>idea at least. Um again, it's it's kind of a

0:31:08.680 --> 0:31:11.800
<v Speaker 1>gruesome topic and sort of it was hard to look

0:31:11.840 --> 0:31:14.479
<v Speaker 1>at the footage. If anybody's curious, it's definitely out there.

0:31:14.520 --> 0:31:19.040
<v Speaker 1>That documentary is on YouTube and little um smatterings, not

0:31:19.160 --> 0:31:30.440
<v Speaker 1>in its entirety, but it's very interesting stuff, all right,

0:31:30.480 --> 0:31:33.760
<v Speaker 1>so they you have it trepidation in all it's uh

0:31:34.400 --> 0:31:41.040
<v Speaker 1>grizzly details and up potentially um you know, mind altering details. Yes,

0:31:41.080 --> 0:31:44.400
<v Speaker 1>we hope that we haven't caused any trepidation about trepidation

0:31:44.480 --> 0:31:46.840
<v Speaker 1>for you. If you'd like to check out more episodes

0:31:46.960 --> 0:31:48.800
<v Speaker 1>of Stuff to Blow your Mind, be sure to go

0:31:48.880 --> 0:31:51.000
<v Speaker 1>to the mothership Stuff to Blow your Mind dot com.

0:31:51.000 --> 0:31:54.160
<v Speaker 1>That's where you'll find all the episodes, uh been podcast form,

0:31:54.160 --> 0:31:56.240
<v Speaker 1>you'll find the videos, you'll find a blog post, links

0:31:56.240 --> 0:31:58.680
<v Speaker 1>out to social media accounts you name it. And if

0:31:58.760 --> 0:32:01.400
<v Speaker 1>you have any thoughts on treport Nation or these sort

0:32:01.440 --> 0:32:05.560
<v Speaker 1>of feats of enlightenment. Let us know. You can email

0:32:05.640 --> 0:32:07.880
<v Speaker 1>us at below the Mind at how stuff works dot

0:32:07.920 --> 0:32:13.080
<v Speaker 1>com for more on this and thousands of other topics.

0:32:13.200 --> 0:32:20.640
<v Speaker 1>Does it How stuff works dot com.