1 00:00:00,320 --> 00:00:02,880 Speaker 1: Brought to you by the reinvented two thousand twelve camera. 2 00:00:03,200 --> 00:00:09,960 Speaker 1: It's ready. Are you welcome to stuff Mom never told you? 3 00:00:10,160 --> 00:00:17,599 Speaker 1: From House stuff Works dot Com. Hello, and welcome to 4 00:00:17,640 --> 00:00:20,880 Speaker 1: the podcast. I'm Kristen and I'm Caroline. Caroline. Why don't 5 00:00:20,880 --> 00:00:24,520 Speaker 1: we start things off with a bit of news. It's 6 00:00:24,560 --> 00:00:30,720 Speaker 1: not new news. I think semi new news. Yeah, may news. 7 00:00:31,120 --> 00:00:33,120 Speaker 1: People who don't frequently keep up with the news will 8 00:00:33,120 --> 00:00:36,959 Speaker 1: maybe not have heard about it. Yes, news for the 9 00:00:37,159 --> 00:00:42,839 Speaker 1: under infum So today we are talking about whether or 10 00:00:42,840 --> 00:00:49,640 Speaker 1: not a pill can cure obesity and the quotes obesity 11 00:00:49,720 --> 00:00:55,080 Speaker 1: epidemic that has been sweeping the United States because an 12 00:00:55,160 --> 00:01:01,160 Speaker 1: FDA advisory committee recently recommended that the agency of not one, 13 00:01:01,400 --> 00:01:06,000 Speaker 1: but two anti obesity drugs. Yeah, it starts with q nexa. 14 00:01:06,560 --> 00:01:08,720 Speaker 1: Back in February, the committee gave a thumbs up to 15 00:01:08,840 --> 00:01:12,800 Speaker 1: that drug, which is made by Vivas or vis It's 16 00:01:12,800 --> 00:01:16,680 Speaker 1: a drug company. It's called Vivis. It's pronounced yeah anyway. Uh. 17 00:01:16,720 --> 00:01:21,080 Speaker 1: This is also there's Lorca sarin brand name would be Lorkess, 18 00:01:21,760 --> 00:01:25,240 Speaker 1: and that is another drug to treat obesity, both of 19 00:01:25,319 --> 00:01:29,039 Speaker 1: which had previously been rejected after they submitted studies to 20 00:01:29,080 --> 00:01:31,200 Speaker 1: this advisory committee and they were like, no, we're not 21 00:01:31,240 --> 00:01:35,240 Speaker 1: convinced that you won't kill people. Yeah. For instance, uh 22 00:01:35,440 --> 00:01:41,399 Speaker 1: Lorkes was initially red lighted because the medications seemed to 23 00:01:41,480 --> 00:01:45,720 Speaker 1: only provide modest weight loss, and there were also some 24 00:01:45,720 --> 00:01:49,600 Speaker 1: studies linking it to mammary tumors in rats, and so 25 00:01:49,720 --> 00:01:52,520 Speaker 1: the drug companies went back, they did more studies, they 26 00:01:52,520 --> 00:01:56,320 Speaker 1: did more tweaking, and came back again, and the FDA 27 00:01:56,560 --> 00:01:59,080 Speaker 1: Advisor Committee is like, all right, you know, put it 28 00:01:59,120 --> 00:02:03,200 Speaker 1: through um putting, pushing it closer to getting these drugs 29 00:02:03,240 --> 00:02:08,040 Speaker 1: on the market. And just on a side note, just 30 00:02:08,280 --> 00:02:12,560 Speaker 1: getting that Advisory committee green light is such a financial 31 00:02:12,560 --> 00:02:18,040 Speaker 1: boon for these companies. Um. Right after Lorcas announced that, 32 00:02:18,160 --> 00:02:21,960 Speaker 1: or I guess Arena Pharmaceuticals that produced Lorcas announced that 33 00:02:22,280 --> 00:02:25,359 Speaker 1: the FDA Advisory Committee Committee had given it the thumbs up, 34 00:02:25,680 --> 00:02:32,639 Speaker 1: shares of uh It's stock skyrocket immediately. Well, I mean 35 00:02:32,880 --> 00:02:35,640 Speaker 1: I can see that because you know they've been and 36 00:02:35,639 --> 00:02:38,160 Speaker 1: we'll get into this, but there have been so many 37 00:02:38,440 --> 00:02:41,600 Speaker 1: attempts at successful obesity drugs that help you lose weight 38 00:02:42,160 --> 00:02:45,520 Speaker 1: and don't actually weaken your heart. UM, So if there 39 00:02:45,560 --> 00:02:48,880 Speaker 1: is something a promising drug to treat an epidemic that 40 00:02:49,000 --> 00:02:52,079 Speaker 1: is very widespread that could potentially make a lot of 41 00:02:52,080 --> 00:02:54,919 Speaker 1: money for a lot of people. Absolutely, and there's also 42 00:02:54,960 --> 00:02:59,000 Speaker 1: the money that goes into all of these clinical trials 43 00:02:59,800 --> 00:03:04,520 Speaker 1: that the pharmaceutical companies have to fund. But kind of 44 00:03:04,560 --> 00:03:06,520 Speaker 1: in the back of my mind, I'm always a little 45 00:03:06,560 --> 00:03:09,720 Speaker 1: wary of all of those hundreds of millions of dollars 46 00:03:09,720 --> 00:03:12,400 Speaker 1: that are going into these drugs because of the potential 47 00:03:12,919 --> 00:03:20,600 Speaker 1: to earn money. But my skepticism aside um. According to 48 00:03:20,680 --> 00:03:24,400 Speaker 1: Forbes Magazine Lord kest and this is now we're talking 49 00:03:24,400 --> 00:03:28,880 Speaker 1: in two thousand twelve, not when the FDA UH initially 50 00:03:28,880 --> 00:03:31,720 Speaker 1: put the brakes on it. Lorkes helps people lose on 51 00:03:31,800 --> 00:03:36,320 Speaker 1: average three percent more weight than diet alone UM and 52 00:03:36,520 --> 00:03:39,520 Speaker 1: will also increase the percentage for people who lose five 53 00:03:39,600 --> 00:03:41,640 Speaker 1: percent of their body weight. So it seems like there's 54 00:03:41,680 --> 00:03:43,640 Speaker 1: kind of a snowball effect there, the more weight that 55 00:03:43,680 --> 00:03:48,320 Speaker 1: they're able to lose with medication and UH dietary changes 56 00:03:48,600 --> 00:03:52,320 Speaker 1: because doctors always advised that with UM clinically obese people 57 00:03:52,560 --> 00:03:54,160 Speaker 1: that they've got to have the it's not just the 58 00:03:54,240 --> 00:03:56,960 Speaker 1: magic bill. There has to be nutritional change that goes 59 00:03:56,960 --> 00:03:59,760 Speaker 1: along with that, and there is more good news because 60 00:03:59,800 --> 00:04:03,320 Speaker 1: the senior VP at Arena, the drug company producing Lorcas, 61 00:04:03,640 --> 00:04:05,760 Speaker 1: says that the cancer they found in these studies is 62 00:04:05,840 --> 00:04:11,560 Speaker 1: rats specific. But it's not all good news because there 63 00:04:11,600 --> 00:04:15,280 Speaker 1: are some people out there's medical experts who still have 64 00:04:15,400 --> 00:04:20,200 Speaker 1: concerns about possible heart valve problems. Um, there are calls 65 00:04:20,240 --> 00:04:25,760 Speaker 1: for more cardiovascular tests across the board for any kind 66 00:04:25,800 --> 00:04:31,520 Speaker 1: of anti obesity drug, probably because of issues with the 67 00:04:31,600 --> 00:04:35,320 Speaker 1: now defunct Finfin, which we'll talk about in a minute. 68 00:04:35,360 --> 00:04:39,480 Speaker 1: That um initially people got excited about because hey, it's 69 00:04:39,520 --> 00:04:41,760 Speaker 1: easy to lose weight, and it's producing all this extra 70 00:04:41,800 --> 00:04:43,719 Speaker 1: serotonin in your brain, so you feel good while you're 71 00:04:43,720 --> 00:04:46,200 Speaker 1: doing it. But then down the road they were like, wait, 72 00:04:46,279 --> 00:04:49,960 Speaker 1: my heart doesn't work quite right. And there are also, 73 00:04:50,560 --> 00:04:54,040 Speaker 1: you know, some potential side effects. Were still talking about 74 00:04:54,600 --> 00:04:59,599 Speaker 1: uh lord kess of headaches and cognitive problems, like the 75 00:04:59,600 --> 00:05:04,960 Speaker 1: potential you for amnesia. But then they might just you know, forget, 76 00:05:06,240 --> 00:05:09,200 Speaker 1: forget that they ever had way to know. I'm about 77 00:05:09,200 --> 00:05:12,039 Speaker 1: to argue in favor of amnisia. Well, I mean it 78 00:05:12,200 --> 00:05:14,560 Speaker 1: sounds like you take a pill and you end up 79 00:05:14,560 --> 00:05:19,520 Speaker 1: on a soap opera. Yeah, you end up thin with amnesia. UM. 80 00:05:19,560 --> 00:05:22,080 Speaker 1: But yeah, Kristen just mentioned that there are more tests 81 00:05:22,080 --> 00:05:25,680 Speaker 1: being called for for these types of medications. And back 82 00:05:25,680 --> 00:05:29,600 Speaker 1: in March, an FDA advisory committee voted to require clinical 83 00:05:29,640 --> 00:05:33,640 Speaker 1: trials to ensure that obesity drugs do not cause heart attacks. 84 00:05:33,640 --> 00:05:36,840 Speaker 1: And this sort of caused an argument because some people 85 00:05:36,880 --> 00:05:39,440 Speaker 1: were saying that this would actually discourage people because it's 86 00:05:39,440 --> 00:05:42,600 Speaker 1: a very expensive process to go back and do all 87 00:05:42,640 --> 00:05:45,159 Speaker 1: these tests over and over again, and a lot of 88 00:05:45,160 --> 00:05:48,720 Speaker 1: tests are performed from the beginning anyway, So a lot 89 00:05:48,720 --> 00:05:51,160 Speaker 1: of people were saying that this added cost, added time 90 00:05:51,160 --> 00:05:55,480 Speaker 1: would discourage people from developing certain obesity drugs. But then 91 00:05:55,480 --> 00:05:58,000 Speaker 1: other people are like, hey, shouldn't we air on the 92 00:05:58,000 --> 00:06:01,120 Speaker 1: side of caution anyway? I mean, and that's okay. So 93 00:06:01,160 --> 00:06:04,440 Speaker 1: we with this issue of whether or not we like 94 00:06:04,520 --> 00:06:09,039 Speaker 1: a pill can cure and quotes obesity. Um. There are 95 00:06:09,040 --> 00:06:11,200 Speaker 1: two big things to talk about. What a what kind 96 00:06:11,200 --> 00:06:14,800 Speaker 1: of problem are we talking about talking about? UM? Like, 97 00:06:14,880 --> 00:06:18,280 Speaker 1: what what is the scope of obesity right now? And 98 00:06:18,320 --> 00:06:21,880 Speaker 1: what might happen if some kind of medication does not 99 00:06:22,360 --> 00:06:26,920 Speaker 1: get on the market that can cause some significant changes? Um? 100 00:06:27,000 --> 00:06:31,200 Speaker 1: And also why has it been so difficult to find 101 00:06:31,480 --> 00:06:36,320 Speaker 1: some kind of anti obesity medication. So first up, let's 102 00:06:36,320 --> 00:06:39,360 Speaker 1: talk about just plain stats on obesity. And we're talking 103 00:06:39,400 --> 00:06:41,960 Speaker 1: about the adult population right now. We're not talking about 104 00:06:42,080 --> 00:06:47,240 Speaker 1: childhood obesity. Um. Some Duke researchers, this was reported in 105 00:06:47,360 --> 00:06:50,919 Speaker 1: Slate in USA today. Some Duke researchers project that the 106 00:06:50,960 --> 00:06:53,920 Speaker 1: percentage of Americans who are severely obese, which would be 107 00:06:53,960 --> 00:06:59,120 Speaker 1: a hundred or more pounds overweight. I'm sorry for metrics 108 00:06:59,120 --> 00:07:02,320 Speaker 1: system listeners right now. I don't don't have that those 109 00:07:02,640 --> 00:07:05,880 Speaker 1: that kilogram conversion or stones. I WI should know how 110 00:07:05,880 --> 00:07:09,400 Speaker 1: many stones that was. But for severely obased people that 111 00:07:09,880 --> 00:07:13,640 Speaker 1: they're projected to nearly double to eleven of the population 112 00:07:13,960 --> 00:07:17,400 Speaker 1: by if we continue in the path that we are on, 113 00:07:17,920 --> 00:07:21,120 Speaker 1: and they project that of the population may end up 114 00:07:21,160 --> 00:07:24,040 Speaker 1: being abased by twenty thirty, which is up from the 115 00:07:24,160 --> 00:07:28,000 Speaker 1: rate of thirty six percent. And if we were to 116 00:07:28,040 --> 00:07:32,880 Speaker 1: just keep it that level of thirty six percent and 117 00:07:33,000 --> 00:07:36,160 Speaker 1: not not hit those those rising levels, just just seeing 118 00:07:36,240 --> 00:07:39,880 Speaker 1: plateaued right where we are. The Duke study co author 119 00:07:40,040 --> 00:07:44,360 Speaker 1: Justin Shrogden says that the United States alone would save 120 00:07:44,440 --> 00:07:48,200 Speaker 1: more than five hundred and forty nine point five billion 121 00:07:48,240 --> 00:07:53,720 Speaker 1: dollars in weight related medical expenditures through twenty thirties. Insane. 122 00:07:53,880 --> 00:07:56,080 Speaker 1: And just on another side note, since we're talking about 123 00:07:56,080 --> 00:07:59,760 Speaker 1: billions of dollars, the US weight loss industry is now 124 00:07:59,880 --> 00:08:03,040 Speaker 1: s made it roughly sixty billion dollars. There's so much 125 00:08:03,040 --> 00:08:06,080 Speaker 1: money everywhere in this conversation. There is a people are 126 00:08:06,120 --> 00:08:10,080 Speaker 1: willing to do almost anything to lose weight except sometimes 127 00:08:10,640 --> 00:08:16,080 Speaker 1: work out. Yes, um, but that's okay. Uh. The projected 128 00:08:16,200 --> 00:08:20,400 Speaker 1: increased rate of obesity, this whole thing with the Duke research, 129 00:08:20,840 --> 00:08:24,640 Speaker 1: that means that thirty two million more obese people will 130 00:08:24,680 --> 00:08:28,560 Speaker 1: show up within two decades show up to the party. Yeah, 131 00:08:28,640 --> 00:08:32,240 Speaker 1: and um. The Duke researchers were trying to figure out 132 00:08:32,400 --> 00:08:37,000 Speaker 1: the factors that might be going into this forecasting, and 133 00:08:37,040 --> 00:08:40,120 Speaker 1: they're looking at things like the unemployment rate, prices of 134 00:08:40,200 --> 00:08:43,720 Speaker 1: fast food, alcohol, and fuel. And if you're thinking about 135 00:08:43,720 --> 00:08:47,840 Speaker 1: the price of fuel, that ties into the sedentary culture 136 00:08:48,360 --> 00:08:50,880 Speaker 1: that we live in right now. I mean, I just 137 00:08:51,000 --> 00:08:53,800 Speaker 1: thinking about myself, Like I take public transit to work 138 00:08:54,040 --> 00:08:58,080 Speaker 1: and I still sit constantly. I actually took public transit 139 00:08:58,160 --> 00:09:00,400 Speaker 1: yesterday and had a woman lying on me on us 140 00:09:00,440 --> 00:09:05,840 Speaker 1: So I'm sorry that was me. I was tired, I 141 00:09:05,920 --> 00:09:09,760 Speaker 1: was standing, So it's pretty impressive. It's also my yoga. 142 00:09:11,400 --> 00:09:13,439 Speaker 1: Um well, I think it is important to ask the 143 00:09:13,520 --> 00:09:17,000 Speaker 1: question of how how accurate are these projections, and Slate 144 00:09:17,200 --> 00:09:20,880 Speaker 1: did ask that question. Um, they might be a little high, 145 00:09:20,920 --> 00:09:24,760 Speaker 1: but they're they're actually pretty accurate. Scarily enough, they point 146 00:09:24,760 --> 00:09:27,760 Speaker 1: out that in two thousand three, the CDC predicted that 147 00:09:27,800 --> 00:09:32,559 Speaker 1: the rate of obesity would be Americans and that was 148 00:09:32,600 --> 00:09:36,080 Speaker 1: pretty close to the actual rate of thirty five point seven. 149 00:09:36,120 --> 00:09:38,840 Speaker 1: And we do have to take into account that forecasting 150 00:09:38,840 --> 00:09:40,760 Speaker 1: like this hasn't been around forever. It's not like we've 151 00:09:40,800 --> 00:09:43,760 Speaker 1: been tracking obesity rates and predicting them for more than 152 00:09:43,800 --> 00:09:46,480 Speaker 1: just about a decade. Yeah, which is surprising, because we 153 00:09:46,520 --> 00:09:50,600 Speaker 1: hear about obesity and just wait in general all the time. 154 00:09:50,600 --> 00:09:54,079 Speaker 1: I feel like we're constantly inundated with information about how 155 00:09:54,120 --> 00:09:57,920 Speaker 1: to either how we're getting fatter or how to lose 156 00:09:57,960 --> 00:10:00,680 Speaker 1: all of that fats one or the other. Um. And 157 00:10:00,960 --> 00:10:03,520 Speaker 1: but it really hasn't been around that long, because it 158 00:10:03,600 --> 00:10:08,000 Speaker 1: was only in n that the Institute of Medicine published 159 00:10:08,000 --> 00:10:10,680 Speaker 1: a study saying that obesity should be perceived as a 160 00:10:10,800 --> 00:10:15,160 Speaker 1: chronic condition like hypertension and recommended that doctors use extended 161 00:10:15,240 --> 00:10:18,120 Speaker 1: drug therapy or surgery to treat it. It was a 162 00:10:18,160 --> 00:10:21,240 Speaker 1: complete shift in mindset from just saying, hey, you know 163 00:10:21,320 --> 00:10:24,120 Speaker 1: you should just go you know, diet exercise to actually 164 00:10:24,840 --> 00:10:33,480 Speaker 1: uh pathologizing weight UM and Scientific American looked into why 165 00:10:34,160 --> 00:10:37,679 Speaker 1: in that time, from when we have that shift in 166 00:10:37,920 --> 00:10:40,959 Speaker 1: the medical community and the perception of obesity and then 167 00:10:41,200 --> 00:10:44,320 Speaker 1: the rising rate of obesity UM just to give you 168 00:10:44,360 --> 00:10:49,839 Speaker 1: an idea, the rates of obesity were stable from around 169 00:10:50,520 --> 00:10:54,120 Speaker 1: the population and then jumped in the nineteen eighties and 170 00:10:54,200 --> 00:10:59,920 Speaker 1: nineties and in two thousand and Meanwhile, doctors have tried 171 00:11:00,080 --> 00:11:03,520 Speaker 1: to develop some kind of anti obesity drugs, but it 172 00:11:03,559 --> 00:11:06,680 Speaker 1: has not been an easy thing to do. No, definitely 173 00:11:06,679 --> 00:11:10,120 Speaker 1: not so. In two thousand four Cornell University study looked 174 00:11:10,160 --> 00:11:13,600 Speaker 1: at obesity drugs their success, who is using them, And 175 00:11:13,600 --> 00:11:16,560 Speaker 1: they looked at nine f d A approved obesity treatment 176 00:11:16,600 --> 00:11:21,080 Speaker 1: drugs in particular that were around between and two thousand one, 177 00:11:21,120 --> 00:11:25,240 Speaker 1: and those were at apex tenuate at a post did 178 00:11:25,280 --> 00:11:27,640 Speaker 1: drex Or directs. I don't know, these names are getting 179 00:11:27,640 --> 00:11:33,040 Speaker 1: still a mazanor, pon, demon redux, Meridia, and zenecalo that 180 00:11:33,080 --> 00:11:36,080 Speaker 1: got easier to resent and if those don't ring many 181 00:11:36,160 --> 00:11:40,880 Speaker 1: bells for listeners. That's because I think Xenical is the 182 00:11:40,960 --> 00:11:46,160 Speaker 1: only one of these drugs that you can even still purchase. Yeah, exactly. Um, 183 00:11:46,480 --> 00:11:49,760 Speaker 1: they they tended to have quite a few side effects, 184 00:11:50,160 --> 00:11:54,760 Speaker 1: and least of which was losing weight. Yes, yes, there 185 00:11:54,800 --> 00:11:57,880 Speaker 1: was no significant weight loss with many of these. Um, 186 00:11:58,240 --> 00:12:01,840 Speaker 1: they definitely worked to suppress appetite, but they also tended, 187 00:12:01,960 --> 00:12:06,319 Speaker 1: you know, to kind of modify your central nervous system neurotransmission. 188 00:12:06,840 --> 00:12:10,559 Speaker 1: So the side effects could definitely be fatal in some 189 00:12:10,640 --> 00:12:14,200 Speaker 1: instances and could have crazy things happen your heart, your 190 00:12:14,720 --> 00:12:17,600 Speaker 1: your mood, your memory, all sorts of things. And so 191 00:12:17,679 --> 00:12:21,719 Speaker 1: there's fin fin which we should talk about, which my 192 00:12:21,760 --> 00:12:24,160 Speaker 1: mother actually took Finfinn, and let me just tell you 193 00:12:24,520 --> 00:12:27,240 Speaker 1: how upset she was. Not about the news about the heart. 194 00:12:27,880 --> 00:12:30,520 Speaker 1: She was just really angry. She had to stop taking, 195 00:12:30,720 --> 00:12:33,200 Speaker 1: probably because she was going to have a serotonin come down. 196 00:12:33,240 --> 00:12:35,520 Speaker 1: But tell, tell the people, tell the kind of people 197 00:12:35,559 --> 00:12:38,240 Speaker 1: out there about the heart valve. Yeah, fin Finn was 198 00:12:38,280 --> 00:12:41,240 Speaker 1: pulled from the market in nineties seven because it damaged 199 00:12:41,240 --> 00:12:43,480 Speaker 1: heart valves, which we've mentioned is a side effect of 200 00:12:43,559 --> 00:12:46,200 Speaker 1: some of these things, and it was a combination of 201 00:12:46,320 --> 00:12:51,960 Speaker 1: pondamin or fin fluoramine, which releases extra serotonin, like Kristen said, 202 00:12:52,360 --> 00:12:56,240 Speaker 1: and the stimulant finn termine. So you you've kind of 203 00:12:56,240 --> 00:12:58,600 Speaker 1: got some ups and downs going here. Yeah. It was 204 00:12:58,679 --> 00:13:03,559 Speaker 1: essentially like a drug cocktail, an OTC cocktail, over the 205 00:13:03,640 --> 00:13:06,240 Speaker 1: counter cocktail that doctors like, oh, hey, here we go, 206 00:13:06,320 --> 00:13:10,000 Speaker 1: we can just balance these scales and just lose that weight. 207 00:13:10,120 --> 00:13:13,640 Speaker 1: But apparently it was tougher on the heart and the 208 00:13:13,640 --> 00:13:17,319 Speaker 1: pharmaceutical company has since had to pay lots of money 209 00:13:17,559 --> 00:13:21,160 Speaker 1: to folks for very expensive surgeries. Yeah. Well, the same 210 00:13:21,240 --> 00:13:24,200 Speaker 1: year that Finfinn was yanked off the market and Meridia launched, 211 00:13:24,320 --> 00:13:27,480 Speaker 1: and it was effective in weight loss, pretty effective. Forty 212 00:13:27,559 --> 00:13:30,440 Speaker 1: six percent of people lost ten percent or more of 213 00:13:30,440 --> 00:13:32,880 Speaker 1: their body weight and clinical trials, which is significantly more 214 00:13:32,880 --> 00:13:36,200 Speaker 1: than what we cited for larks over here, which was 215 00:13:36,320 --> 00:13:39,640 Speaker 1: three percent and five percent um. But it affected the 216 00:13:39,679 --> 00:13:43,079 Speaker 1: heart rate and was withdrawn in And now it's starting 217 00:13:43,120 --> 00:13:48,040 Speaker 1: to make sense why, uh, these medical experts have recently 218 00:13:48,040 --> 00:13:51,280 Speaker 1: come out saying, hey, we need cardiovascular tests. They must 219 00:13:51,280 --> 00:13:56,400 Speaker 1: be rigorous because all of these uh former ANTIBC drugs 220 00:13:56,400 --> 00:13:59,079 Speaker 1: and it being pulled because of heart related issues. And 221 00:13:59,120 --> 00:14:01,920 Speaker 1: then we have zen accou, which Kristen points out points 222 00:14:01,960 --> 00:14:04,400 Speaker 1: out as one of the few names that I actually 223 00:14:04,400 --> 00:14:10,840 Speaker 1: recognized that launched and happy not insignificant side effects of 224 00:14:10,880 --> 00:14:14,679 Speaker 1: oily stools and flatulence. So God help you. If you 225 00:14:14,720 --> 00:14:17,680 Speaker 1: were taking zenacal and eating a lustrac chips, well that's 226 00:14:17,720 --> 00:14:22,440 Speaker 1: the thing. Uh, If you regulated your diet, had a 227 00:14:22,520 --> 00:14:25,520 Speaker 1: very low fat diet and seneca, you'd be fine. But 228 00:14:25,840 --> 00:14:31,040 Speaker 1: if you decided to blurge and have a parfit or 229 00:14:31,160 --> 00:14:35,640 Speaker 1: some French fries, then you'd have a Well you have 230 00:14:35,680 --> 00:14:37,520 Speaker 1: oily stools. I'll just leave it at that, right, Well, 231 00:14:37,560 --> 00:14:41,040 Speaker 1: that's because your body isn't absorbing it or or digesting it. 232 00:14:41,040 --> 00:14:44,480 Speaker 1: It's just passing. The fat is just passing right through you. 233 00:14:44,720 --> 00:14:48,720 Speaker 1: And I'm glad you mentioned o Leustra chips because front 234 00:14:48,760 --> 00:14:52,960 Speaker 1: Line over PBS I didn't end that story on the 235 00:14:53,000 --> 00:14:58,600 Speaker 1: fen Fenn craze. And essentially, how you know we have 236 00:14:59,200 --> 00:15:01,040 Speaker 1: you know, the studies coming out saying that we need 237 00:15:01,080 --> 00:15:04,000 Speaker 1: to treat obesity. Obesity is becoming a problem and people 238 00:15:04,000 --> 00:15:07,280 Speaker 1: start getting aware of it, and we want to lose 239 00:15:07,320 --> 00:15:09,800 Speaker 1: this weight. And by we, I mean I'm talking more 240 00:15:09,840 --> 00:15:12,760 Speaker 1: specifically about Americans, but we don't really want to change 241 00:15:12,760 --> 00:15:17,280 Speaker 1: our lifestyles necessarily, and so you have all of a 242 00:15:17,320 --> 00:15:22,040 Speaker 1: sudden this bonanza of low fat junk food. This is 243 00:15:22,080 --> 00:15:25,360 Speaker 1: when brands like snack Wells come up and make bookoos 244 00:15:25,400 --> 00:15:27,880 Speaker 1: of money because you can still ey cookies because they're 245 00:15:27,920 --> 00:15:32,360 Speaker 1: just fat free. Or my favorite product, which I remember 246 00:15:32,400 --> 00:15:35,280 Speaker 1: when it first came out, I was I was pretty 247 00:15:35,280 --> 00:15:37,680 Speaker 1: pumped about it because I liked potato chips, but it 248 00:15:37,720 --> 00:15:41,280 Speaker 1: was those o Lustri chips which really did taste like 249 00:15:41,360 --> 00:15:44,280 Speaker 1: normal potato chips, but they were fat free. Um. But 250 00:15:44,360 --> 00:15:46,240 Speaker 1: if you ate too many, you would be on the 251 00:15:46,280 --> 00:15:50,360 Speaker 1: toilet for quite a while because those that's just a 252 00:15:50,440 --> 00:15:53,640 Speaker 1: load right through well. We we had all of that 253 00:15:53,680 --> 00:15:56,160 Speaker 1: stuff in my house because my dad had a heart attack. 254 00:15:57,240 --> 00:15:58,800 Speaker 1: So that's like right at the peak of all this 255 00:15:59,600 --> 00:16:02,480 Speaker 1: healthy junk food coming out, and it's like, I know, 256 00:16:02,520 --> 00:16:05,320 Speaker 1: it's it's really hard. Dieting is a lifestyle change, and 257 00:16:05,400 --> 00:16:07,880 Speaker 1: it's hard to all of a sudden go from you know, 258 00:16:08,000 --> 00:16:11,760 Speaker 1: eating kind of tasty junk food too, being told you 259 00:16:11,800 --> 00:16:14,120 Speaker 1: need to just stick to fruits and vegetables basically, So 260 00:16:14,240 --> 00:16:18,480 Speaker 1: we those weird snack foods definitely aided his transition. And 261 00:16:18,520 --> 00:16:21,240 Speaker 1: also we have to you know, acknowledge things like thyroid 262 00:16:21,240 --> 00:16:24,320 Speaker 1: problems and other genetic problems that might make it harder 263 00:16:24,360 --> 00:16:27,160 Speaker 1: for you to lose weight or impossible for you to 264 00:16:27,200 --> 00:16:29,320 Speaker 1: lose weight. And if we're talking about obesity as well, 265 00:16:29,920 --> 00:16:31,920 Speaker 1: the it's not a snap of the fingers hop on 266 00:16:31,960 --> 00:16:35,520 Speaker 1: a treadmill, because you know, there are health problems that 267 00:16:35,560 --> 00:16:38,360 Speaker 1: could or health risks that could even go along with 268 00:16:38,560 --> 00:16:42,720 Speaker 1: intensive exercise. So the you know, plenty of doctors have 269 00:16:42,840 --> 00:16:46,040 Speaker 1: stressed the need for some kind of anti obesity drug, 270 00:16:46,080 --> 00:16:49,720 Speaker 1: which does seem like a much better alternative to poop 271 00:16:49,800 --> 00:16:57,200 Speaker 1: chip um exactly. Um. But this Cornell study looked at 272 00:16:57,200 --> 00:17:01,040 Speaker 1: who exactly is taking this medicine, and it's kind of 273 00:17:01,080 --> 00:17:03,720 Speaker 1: surprising because basically they found that the people who really 274 00:17:03,720 --> 00:17:08,040 Speaker 1: should be taking it, the severely obese population, only one 275 00:17:08,520 --> 00:17:12,080 Speaker 1: of those people who meet the medical criteria are taking 276 00:17:12,119 --> 00:17:16,880 Speaker 1: the medicine. Of those taking anti obesity drugs don't meet 277 00:17:16,920 --> 00:17:19,280 Speaker 1: the medical criteria for their use. So that means that 278 00:17:19,320 --> 00:17:22,200 Speaker 1: for every two point to nine people, so like two 279 00:17:22,200 --> 00:17:26,200 Speaker 1: tall people and a short person maybe taking for every 280 00:17:26,200 --> 00:17:28,480 Speaker 1: two point to nine people taking such a drug who 281 00:17:28,520 --> 00:17:31,960 Speaker 1: meet the criteria, another person using it doesn't And we 282 00:17:32,000 --> 00:17:34,800 Speaker 1: should also emphasize we probably should have said this earlier 283 00:17:34,800 --> 00:17:39,800 Speaker 1: in the podcast. We're talking specifically about prescription anti obesity pills, 284 00:17:39,960 --> 00:17:44,040 Speaker 1: not over the counter pills. If you are, you know, 285 00:17:44,280 --> 00:17:48,600 Speaker 1: trying to drop a few pounds before um, I don't know, 286 00:17:49,000 --> 00:17:54,240 Speaker 1: uh sure. And we should also say too that the 287 00:17:54,320 --> 00:17:57,960 Speaker 1: Cornell study pointed out that whether or not someone has 288 00:17:58,040 --> 00:18:02,680 Speaker 1: prescription drug coverage with health care insurance will also make 289 00:18:02,680 --> 00:18:05,919 Speaker 1: a difference, because those who do are fifty seven percent 290 00:18:06,080 --> 00:18:09,639 Speaker 1: more likely than those without coverage to use anti obesity drugs. 291 00:18:09,640 --> 00:18:13,000 Speaker 1: Because I can imagine if these are you know, there 292 00:18:13,000 --> 00:18:15,320 Speaker 1: are not generics of these kinds of drugs, and they're 293 00:18:15,320 --> 00:18:19,960 Speaker 1: probably pretty expensive. So we haven't talked about gender yet 294 00:18:20,000 --> 00:18:23,720 Speaker 1: in the podcast, but if we're talking about weight loss, 295 00:18:24,160 --> 00:18:28,280 Speaker 1: as you can imagine, there is plenty of gender information 296 00:18:28,440 --> 00:18:31,760 Speaker 1: out there. Yeah. According to the National Health and Nutrition 297 00:18:31,800 --> 00:18:36,479 Speaker 1: Examination Study from in two thousand, more men than women 298 00:18:36,600 --> 00:18:41,640 Speaker 1: were overweight or obese. Um, but it looks like more 299 00:18:41,680 --> 00:18:46,560 Speaker 1: women are actually taking these prescription anti obesity drugs. Once again, 300 00:18:46,840 --> 00:18:49,439 Speaker 1: signing that Cornell study from two thousand, four, women are 301 00:18:50,320 --> 00:18:53,520 Speaker 1: how about this A hundred and eighty one cent more 302 00:18:53,640 --> 00:18:57,639 Speaker 1: likely to use anti obesity drugs, and it is probably 303 00:18:57,680 --> 00:19:01,800 Speaker 1: because women tend to be more motivate aded to lose 304 00:19:01,880 --> 00:19:06,359 Speaker 1: weight than men are, because well, hey, we've talked about 305 00:19:06,359 --> 00:19:10,280 Speaker 1: before in the podcast, how physiologically it is harder for 306 00:19:10,400 --> 00:19:14,040 Speaker 1: women to lose weight. Men can drop pounds quicker because 307 00:19:14,040 --> 00:19:17,639 Speaker 1: of the muscle mass, et cetera. Um. According to a 308 00:19:17,680 --> 00:19:23,720 Speaker 1: two thousand eleven gallop pole, sevent of American women have 309 00:19:23,760 --> 00:19:27,760 Speaker 1: attempted to lose weight an average of seven times, compared 310 00:19:27,800 --> 00:19:30,760 Speaker 1: to fifty of men who have attempted to lose weight 311 00:19:30,800 --> 00:19:34,240 Speaker 1: an average of four times. It's they that's a huge gap. 312 00:19:34,600 --> 00:19:36,600 Speaker 1: It is a huge gap. And yet women are actually 313 00:19:36,680 --> 00:19:39,640 Speaker 1: less likely, according to that galop Pole, to cite exercise 314 00:19:41,080 --> 00:19:45,240 Speaker 1: as helping them lose weight. In the poop chips, God, 315 00:19:45,359 --> 00:19:50,199 Speaker 1: you've God, he brought up a lestra I did it 316 00:19:50,280 --> 00:19:53,720 Speaker 1: is my fault that you called them poop chips? Um. 317 00:19:53,760 --> 00:19:57,040 Speaker 1: There are other factors that Cornell looked at in looking 318 00:19:57,040 --> 00:20:01,200 Speaker 1: at who is taking these prescription obesity draw um. They 319 00:20:01,200 --> 00:20:04,400 Speaker 1: controlled for whether the survey respondents met the medical criteria 320 00:20:04,520 --> 00:20:07,480 Speaker 1: for using these drugs and found that African Americans were 321 00:20:07,520 --> 00:20:11,840 Speaker 1: only as likely as whites to use them. Yeah, and 322 00:20:12,160 --> 00:20:15,679 Speaker 1: with Hispanics there were only seventy as likely as whites 323 00:20:15,720 --> 00:20:18,640 Speaker 1: to use the drugs. So even if let's say those 324 00:20:18,680 --> 00:20:21,520 Speaker 1: two drugs we talked about at the top of the podcast, 325 00:20:21,560 --> 00:20:24,760 Speaker 1: Lorcus and Quenexa get the green light, they end up 326 00:20:24,760 --> 00:20:26,280 Speaker 1: on the market, the question is going to be whether 327 00:20:26,400 --> 00:20:29,520 Speaker 1: or not they actually get into the hands of the 328 00:20:29,560 --> 00:20:36,280 Speaker 1: population that medically could benefit from them. So that's a 329 00:20:36,280 --> 00:20:39,720 Speaker 1: big question that we've got to ask um. And also 330 00:20:39,800 --> 00:20:43,199 Speaker 1: in the meantime, there are all these over the counter 331 00:20:43,520 --> 00:20:47,440 Speaker 1: diet pills that I'm sure everyone is seen in drug 332 00:20:47,480 --> 00:20:52,840 Speaker 1: stores or on advertisements promising to lose weight quickly. And 333 00:20:53,080 --> 00:20:54,919 Speaker 1: we don't need to go to in depth on it 334 00:20:55,320 --> 00:21:00,159 Speaker 1: except to say that really take the well, don't take him. 335 00:21:00,359 --> 00:21:05,080 Speaker 1: But I'm saying take the advertisements with a grain of salt. Yeah, 336 00:21:05,119 --> 00:21:08,440 Speaker 1: And like in h for Ally for instance, that over 337 00:21:08,480 --> 00:21:12,200 Speaker 1: the counter diet pill, they encourage you in the ad 338 00:21:12,280 --> 00:21:15,760 Speaker 1: to make it part of a healthy diet and exercise 339 00:21:16,359 --> 00:21:19,199 Speaker 1: because you know, we've already talked about the poop chips. 340 00:21:19,560 --> 00:21:23,240 Speaker 1: Ally is just or Lesstat all over again, but it's 341 00:21:23,280 --> 00:21:25,880 Speaker 1: in a reduced strength version. And so the Mayo Clinic 342 00:21:26,520 --> 00:21:30,040 Speaker 1: basically tells you that bowel changes will result from the 343 00:21:30,119 --> 00:21:33,360 Speaker 1: undigested fat moving through your system, So eat that low 344 00:21:33,359 --> 00:21:35,680 Speaker 1: fat diet. If you're taking an over the counter pill 345 00:21:35,760 --> 00:21:38,960 Speaker 1: like ally, because it ends up decreasing the absorption of 346 00:21:38,960 --> 00:21:41,320 Speaker 1: some vitamins. Yeah, yeah, so you'll need to take those 347 00:21:41,320 --> 00:21:43,800 Speaker 1: supplements um as well. And of course the Mayo Clinic 348 00:21:43,880 --> 00:21:46,480 Speaker 1: urges you to talk to your doctor first. And remember 349 00:21:46,760 --> 00:21:49,639 Speaker 1: there are no quick fixes when it comes to popping 350 00:21:49,680 --> 00:21:53,159 Speaker 1: a pill to lose some weight. Generally, the first course 351 00:21:53,160 --> 00:21:55,880 Speaker 1: of action is changing the diet and exercise. With all 352 00:21:55,920 --> 00:21:59,560 Speaker 1: of these drugs that we have talked about, there's repeated 353 00:21:59,600 --> 00:22:05,320 Speaker 1: mention of the prescription along with the nutritional counseling to 354 00:22:05,359 --> 00:22:08,280 Speaker 1: make sure that you're eating more healthily. And who's to 355 00:22:08,320 --> 00:22:09,880 Speaker 1: say that in the future we won't have a really 356 00:22:09,880 --> 00:22:12,720 Speaker 1: successful diet drug, one that doesn't cause hard problems, helps 357 00:22:12,720 --> 00:22:15,320 Speaker 1: you lose weight, and doesn't make you poop all the time. Um. 358 00:22:16,040 --> 00:22:19,119 Speaker 1: Scientific American actually pointed out that obesity drugs in the 359 00:22:19,160 --> 00:22:21,960 Speaker 1: future could be a replacement for weight loss surgery, which, 360 00:22:22,240 --> 00:22:23,919 Speaker 1: although it is successful for a lot of people, it 361 00:22:23,960 --> 00:22:26,879 Speaker 1: is pretty dangerous. So if we end up with a 362 00:22:26,920 --> 00:22:32,120 Speaker 1: really good, successful relatively healthy diet drug, anti obesity drug. 363 00:22:32,160 --> 00:22:34,640 Speaker 1: You know, maybe that could help with the surgery stuff. Yeah, 364 00:22:34,680 --> 00:22:37,399 Speaker 1: I mean it seems like from what the doctors who 365 00:22:37,440 --> 00:22:40,520 Speaker 1: are seeing all of these patients are saying, yes, we 366 00:22:40,560 --> 00:22:44,640 Speaker 1: need some kind of medical treatment, and you know too, 367 00:22:45,000 --> 00:22:50,520 Speaker 1: as an alternative to something like gastric bypass surgery. But uh, 368 00:22:50,560 --> 00:22:52,719 Speaker 1: it's it's hard to figure out how to do that 369 00:22:52,800 --> 00:22:57,880 Speaker 1: without endangering our hearts and our brains and our bodies. 370 00:22:59,080 --> 00:23:03,040 Speaker 1: So with at first of all, I apologize to listeners 371 00:23:03,040 --> 00:23:06,960 Speaker 1: for the excessive use of the phrase poop chips, and 372 00:23:07,119 --> 00:23:10,680 Speaker 1: I think I deserve an apology. And I apologize to 373 00:23:10,960 --> 00:23:14,359 Speaker 1: Caroline uh, and I will not ask for your for 374 00:23:14,400 --> 00:23:18,080 Speaker 1: your feedback. What do you think about, um, these anti 375 00:23:18,080 --> 00:23:20,359 Speaker 1: obesity drugs. Do you think the FDA should be more careful? 376 00:23:20,359 --> 00:23:22,760 Speaker 1: Do you think that they should actually speed up the 377 00:23:22,760 --> 00:23:26,160 Speaker 1: process get these things on the market? Um, and also 378 00:23:26,520 --> 00:23:30,720 Speaker 1: advertisements for over the counter diet pills, stuff like that. 379 00:23:31,320 --> 00:23:33,199 Speaker 1: I don't know. Let us know your thoughts, mom. Stuff 380 00:23:33,359 --> 00:23:36,520 Speaker 1: at Discovery dot com is where you can send your letters. 381 00:23:36,960 --> 00:23:39,119 Speaker 1: And the meantime, we've got a couple here from some 382 00:23:39,240 --> 00:23:47,640 Speaker 1: older episodes. My first email here from Nicole is in 383 00:23:47,680 --> 00:23:53,680 Speaker 1: regard to our long ago podcast on gender segregated education. 384 00:23:54,320 --> 00:23:56,680 Speaker 1: She writes, I went to an all girls Catholic high 385 00:23:56,680 --> 00:23:59,240 Speaker 1: school at that age. Being in an all girls class 386 00:23:59,280 --> 00:24:01,400 Speaker 1: was great, mostly because I was so shy. It really 387 00:24:01,440 --> 00:24:04,280 Speaker 1: helped me build confidence. Plus there were less distractions in 388 00:24:04,320 --> 00:24:08,280 Speaker 1: the classroom. We never had much trouble finding dates. You 389 00:24:08,280 --> 00:24:10,920 Speaker 1: guys mentioned that girls may be more awkward around guys 390 00:24:11,000 --> 00:24:14,520 Speaker 1: since they wouldn't have as much experience socializing with them. 391 00:24:14,560 --> 00:24:17,480 Speaker 1: Totally not true. After high school, I went to college 392 00:24:17,480 --> 00:24:19,920 Speaker 1: to get a degree in civil engineering, so I had 393 00:24:19,960 --> 00:24:21,639 Speaker 1: class with a lot of guys, and almost all of 394 00:24:21,640 --> 00:24:24,680 Speaker 1: my professors were guys. Sometimes I was the only girl 395 00:24:24,680 --> 00:24:26,679 Speaker 1: in class, but I got used to it very quickly 396 00:24:26,760 --> 00:24:29,240 Speaker 1: and it wasn't too awkward. It was actually quite nice 397 00:24:29,520 --> 00:24:31,800 Speaker 1: since you're the only girl the guys sent to remember 398 00:24:31,800 --> 00:24:34,639 Speaker 1: you so occasionally. At a house party, I got to 399 00:24:34,640 --> 00:24:37,240 Speaker 1: cut the kegline and even scored a few free beers 400 00:24:37,320 --> 00:24:39,960 Speaker 1: at the bar. My housemates were a little jealous that 401 00:24:40,040 --> 00:24:44,960 Speaker 1: the nerdy girl knew so many guys. It's always nice 402 00:24:45,000 --> 00:24:49,240 Speaker 1: to cut a kegline, That's what I always say. Uh. 403 00:24:49,359 --> 00:24:52,679 Speaker 1: This is an email from Hannah about the Midwife episode. 404 00:24:52,760 --> 00:24:54,600 Speaker 1: She said, I just finished listening to your episode on 405 00:24:54,640 --> 00:24:57,200 Speaker 1: dulas and midwives and thought i'd pipe in with my story, 406 00:24:57,320 --> 00:24:59,880 Speaker 1: even if I'm a year late. I gave birth eight 407 00:25:00,000 --> 00:25:02,320 Speaker 1: months ago and had both a midwife and a dulah. 408 00:25:02,400 --> 00:25:04,760 Speaker 1: I also delivered at a birthing center, and I can 409 00:25:04,760 --> 00:25:07,080 Speaker 1: say from experience that having both was the most important 410 00:25:07,119 --> 00:25:09,760 Speaker 1: thing I ever did. I am considered low income, and 411 00:25:09,800 --> 00:25:12,399 Speaker 1: my dula decided to provide her services free of charge, 412 00:25:12,440 --> 00:25:13,840 Speaker 1: and it was because of her that I had an 413 00:25:13,920 --> 00:25:17,480 Speaker 1: unmedicated i e. Natural birth. This woman had no pain 414 00:25:17,600 --> 00:25:20,320 Speaker 1: killers at the times when I was overcome. It was 415 00:25:20,359 --> 00:25:23,280 Speaker 1: her soothing voice that kept me going. After I gave birth, 416 00:25:23,280 --> 00:25:26,320 Speaker 1: there were some complications. I had hemorrhaging. My midwife not 417 00:25:26,359 --> 00:25:28,320 Speaker 1: only kept a cool head, but also didn't just wait 418 00:25:28,359 --> 00:25:30,680 Speaker 1: around until the medics came. She acted quickly and ended 419 00:25:30,760 --> 00:25:33,439 Speaker 1: up saving my life. However, when I was transferred to 420 00:25:33,440 --> 00:25:36,359 Speaker 1: the hospital, my midwife was able to stay, my dulah 421 00:25:36,400 --> 00:25:38,280 Speaker 1: was told she had to leave. I was pretty out 422 00:25:38,280 --> 00:25:39,520 Speaker 1: of it at the time, so I didn't know what 423 00:25:39,560 --> 00:25:41,800 Speaker 1: was going on. After I came out of my days, 424 00:25:41,840 --> 00:25:44,119 Speaker 1: I was so furious that a hospital which claims to 425 00:25:44,119 --> 00:25:46,760 Speaker 1: be very woman centered with the best of start tricks around. 426 00:25:47,119 --> 00:25:49,720 Speaker 1: Didn't have enough respect to allow my Duelah to stay. 427 00:25:50,200 --> 00:25:53,200 Speaker 1: Perhaps Duela's are seen is pushy and nonconformist, but mine 428 00:25:53,320 --> 00:25:56,000 Speaker 1: isn't and is the sweetest, most gentle woman I know. 429 00:25:56,160 --> 00:25:58,320 Speaker 1: We are still in contact and I count her as 430 00:25:58,359 --> 00:26:02,440 Speaker 1: a friend. So thanks to everybody who's written in. Mom 431 00:26:02,560 --> 00:26:04,840 Speaker 1: Stuff at Discovery dot Com is where you can send 432 00:26:04,840 --> 00:26:08,240 Speaker 1: your letters. You can also find us on Facebook and 433 00:26:08,359 --> 00:26:12,200 Speaker 1: follow us on Twitter at mom Stuff Podcast, and if 434 00:26:12,240 --> 00:26:13,880 Speaker 1: you would like to see what we're up to during 435 00:26:13,880 --> 00:26:15,920 Speaker 1: the week, you can head over to our website, It's 436 00:26:15,960 --> 00:26:21,760 Speaker 1: how Stuff works dot com for more on this and 437 00:26:21,840 --> 00:26:24,400 Speaker 1: thousands of other topics. Is it how stuff works dot 438 00:26:24,400 --> 00:26:32,240 Speaker 1: com brought to you by the reinvented two thousand twelve camera. 439 00:26:32,560 --> 00:26:33,720 Speaker 1: It's ready, are you