1 00:00:03,120 --> 00:00:06,000 Speaker 1: Welcome to Stuff to Blow Your Mind from how Stuff 2 00:00:06,000 --> 00:00:13,280 Speaker 1: Works dot Com. Hey you welcome to Stuff to Blow 3 00:00:13,320 --> 00:00:15,120 Speaker 1: your Mind. My name is Robert Lamb in my name 4 00:00:15,160 --> 00:00:18,560 Speaker 1: is Julie Douglas. In this episode, we are talking about poop, 5 00:00:18,640 --> 00:00:20,919 Speaker 1: which is which is great because I feel like with 6 00:00:21,000 --> 00:00:23,920 Speaker 1: my daily life with a toddler, like poop is uh 7 00:00:24,320 --> 00:00:27,960 Speaker 1: is an important subject. It's it's always coming up. I mean, 8 00:00:28,000 --> 00:00:31,639 Speaker 1: it's always coming out, all right, um, but it's it's 9 00:00:31,760 --> 00:00:33,960 Speaker 1: one of the things that I end up talking about 10 00:00:34,000 --> 00:00:37,040 Speaker 1: with the child when we talk about poop and when 11 00:00:37,040 --> 00:00:38,879 Speaker 1: he needs to poop and how we're going to go 12 00:00:38,920 --> 00:00:41,680 Speaker 1: about it, and then uh, and then when we have 13 00:00:41,720 --> 00:00:44,080 Speaker 1: conversations about it on like the changing table, when I 14 00:00:44,120 --> 00:00:46,360 Speaker 1: put his night diaper on him and he starts talking 15 00:00:46,440 --> 00:00:49,159 Speaker 1: to me about poop and because he knows that the 16 00:00:49,280 --> 00:00:51,760 Speaker 1: night diaper is there in case of night poops. So 17 00:00:51,800 --> 00:00:54,480 Speaker 1: it's fitting. I was on saying that I should uh 18 00:00:54,600 --> 00:00:57,960 Speaker 1: hand over another portion of my day considerations of poop. 19 00:00:58,080 --> 00:01:02,319 Speaker 1: It's fertile ground to tread on. Yes, um, we are 20 00:01:02,400 --> 00:01:06,039 Speaker 1: of course going to be talking about pecal transplants, which 21 00:01:06,040 --> 00:01:08,440 Speaker 1: we've talked about in a cursory way in the past, 22 00:01:08,480 --> 00:01:10,400 Speaker 1: but we thought, you know what it really deserves this 23 00:01:10,560 --> 00:01:13,120 Speaker 1: day out there in the sun. Yeah, like the episode 24 00:01:13,120 --> 00:01:14,560 Speaker 1: that we talked about it, and like we didn't even 25 00:01:14,560 --> 00:01:17,520 Speaker 1: have fecal transplant in the in the title and uh 26 00:01:17,520 --> 00:01:19,520 Speaker 1: and afterwards, I kept kicking myself. It's like people are 27 00:01:19,520 --> 00:01:22,640 Speaker 1: going wild about pecal transplants, wild about it. They are, 28 00:01:22,680 --> 00:01:26,440 Speaker 1: I mean, the headlines everywhere about fecal transplantation and and 29 00:01:26,520 --> 00:01:29,319 Speaker 1: you know Coldbert Daily Show, everybody's throwing in jokes about 30 00:01:29,360 --> 00:01:33,319 Speaker 1: it because you just can't resist the scatological implications here. 31 00:01:33,720 --> 00:01:36,119 Speaker 1: And uh, so we decided, yeah, let's go back, let's 32 00:01:36,200 --> 00:01:39,920 Speaker 1: let's discuss it. Let's discuss some new uh um information 33 00:01:39,959 --> 00:01:43,160 Speaker 1: that's out there about the procedure and about the technology 34 00:01:43,200 --> 00:01:45,360 Speaker 1: and the idea behind it, and uh and just really 35 00:01:45,360 --> 00:01:47,760 Speaker 1: own up to it. Because that's another thing about now 36 00:01:47,800 --> 00:01:49,760 Speaker 1: being the father of a toddler, is that I am 37 00:01:50,040 --> 00:01:54,000 Speaker 1: far more um open about poop. I'm more likely to 38 00:01:54,040 --> 00:01:56,080 Speaker 1: make a poop joke, I'm more likely to discuss it, 39 00:01:56,400 --> 00:01:59,320 Speaker 1: I'm more likely to just be open about about what 40 00:01:59,400 --> 00:02:01,960 Speaker 1: my my own bowel movements are doing in the course 41 00:02:01,960 --> 00:02:03,800 Speaker 1: of the day. It's just really changed my life in 42 00:02:03,800 --> 00:02:06,800 Speaker 1: that respect. Welcome to the world of schatology. It's a 43 00:02:06,800 --> 00:02:12,440 Speaker 1: beautiful place. Um. Well, yeah, Feces as a medicine really 44 00:02:12,440 --> 00:02:15,600 Speaker 1: goes back to the fourth century China, where it was 45 00:02:15,800 --> 00:02:19,720 Speaker 1: orally given to those suffering from food poisoning or severe diarrhea. 46 00:02:20,400 --> 00:02:24,160 Speaker 1: And in the sixteenth century in China, a fecal suspension 47 00:02:24,240 --> 00:02:30,359 Speaker 1: called quote yellow soup was created for the relief of constipation, fever, pain, diarrhea, 48 00:02:30,400 --> 00:02:35,320 Speaker 1: and vomiting. And fast forward, fecal animals were first used 49 00:02:35,360 --> 00:02:40,240 Speaker 1: to treat pseudo membrennous colitis. So it's been around this 50 00:02:40,320 --> 00:02:44,800 Speaker 1: concept of using this beneficial gut flora. Yeah, to your point, 51 00:02:44,840 --> 00:02:48,240 Speaker 1: it's uh, it's an idea that existed before modern medicine, 52 00:02:48,440 --> 00:02:51,400 Speaker 1: and modern medicine has gotten back around to it and 53 00:02:51,440 --> 00:02:54,519 Speaker 1: seeing the value in it. Yeah. I mean essentially there's 54 00:02:54,560 --> 00:02:57,960 Speaker 1: gold in them their poo. Yeah. And I love to 55 00:02:57,960 --> 00:03:01,160 Speaker 1: throw out this quote because I think it's true. Um, 56 00:03:01,160 --> 00:03:05,760 Speaker 1: this is according to Stanford microbiologists Stanley Falco, the world 57 00:03:06,000 --> 00:03:10,400 Speaker 1: is covered in a fine patina of feces. And you 58 00:03:10,440 --> 00:03:12,480 Speaker 1: and I have discussed this before, Like any time that 59 00:03:12,480 --> 00:03:15,280 Speaker 1: you're digging into the dirt, you have to know that 60 00:03:15,320 --> 00:03:18,240 Speaker 1: there are particles of dinosaur poop there, right, Yeah, And 61 00:03:18,320 --> 00:03:20,920 Speaker 1: there's there's poop in the ground, there's poop, you know, 62 00:03:20,960 --> 00:03:23,440 Speaker 1: potentially the air around you. I mean, you're every day 63 00:03:23,480 --> 00:03:25,679 Speaker 1: you're dealing with poop. We in our lives, we often 64 00:03:25,720 --> 00:03:28,600 Speaker 1: try to to limit ourselves not only from the reality 65 00:03:28,600 --> 00:03:31,480 Speaker 1: of poop, but just the the notion of poop. Um. 66 00:03:32,480 --> 00:03:34,560 Speaker 1: We we don't like to think about it in terms 67 00:03:34,600 --> 00:03:38,800 Speaker 1: of our our water purification systems or or or anything. 68 00:03:38,800 --> 00:03:41,360 Speaker 1: It's one of the reasons our toilet systems haven't really 69 00:03:41,360 --> 00:03:44,400 Speaker 1: evolved out that much because we're we're far more content 70 00:03:44,520 --> 00:03:46,640 Speaker 1: just to say, all right, it works, it flushes the 71 00:03:46,640 --> 00:03:48,320 Speaker 1: pool away in clean water. I don't want to think 72 00:03:48,320 --> 00:03:51,360 Speaker 1: about it anymore. But all that poop has been really beneficial, right, 73 00:03:51,440 --> 00:03:54,600 Speaker 1: because if you think about all the dinosaur done, the 74 00:03:54,600 --> 00:03:57,160 Speaker 1: billions of pounds of it that seated the earth, that 75 00:03:57,320 --> 00:04:01,880 Speaker 1: helped other creatures to sprout forth, and other sort of 76 00:04:02,360 --> 00:04:07,080 Speaker 1: plants and animals to subsist. So there's a definite symbiotic 77 00:04:07,160 --> 00:04:09,400 Speaker 1: quality to it, although you don't tend to think about 78 00:04:09,440 --> 00:04:15,960 Speaker 1: that when you're thinking about living with someone and there microbiota, yeah, 79 00:04:16,040 --> 00:04:19,000 Speaker 1: I mean, the microbiot is key here because we've we've 80 00:04:19,040 --> 00:04:21,600 Speaker 1: we've devoted whole episodes of this in the past talking 81 00:04:21,640 --> 00:04:25,680 Speaker 1: about just the the the the microbiota, the the the 82 00:04:25,680 --> 00:04:28,159 Speaker 1: creatures that that make us up. They live inside us 83 00:04:28,440 --> 00:04:30,960 Speaker 1: um and they live in our poop. I mean, our 84 00:04:31,040 --> 00:04:35,440 Speaker 1: our poop is is mostly bacteria, and in a sense, 85 00:04:35,480 --> 00:04:38,120 Speaker 1: we are our poop and the senior we own up 86 00:04:38,160 --> 00:04:40,800 Speaker 1: to that the center, we can we can really get 87 00:04:40,800 --> 00:04:43,600 Speaker 1: along with a number of the the implications of the 88 00:04:43,600 --> 00:04:46,080 Speaker 1: studies that we're discussing in this episode. Yes, so it's 89 00:04:46,080 --> 00:04:47,800 Speaker 1: not really like I am what I eat, It's I 90 00:04:47,839 --> 00:04:50,760 Speaker 1: am what I poop. Right, Yeah, I mean we're not 91 00:04:50,800 --> 00:04:52,840 Speaker 1: just this brain where this whole body, and we're not 92 00:04:52,920 --> 00:04:56,440 Speaker 1: just this the body as it would exist if if 93 00:04:56,480 --> 00:04:58,760 Speaker 1: it was taken to a mortuary and flush clean of 94 00:04:58,800 --> 00:05:02,200 Speaker 1: all its fluids, and because those fluids are essentially us 95 00:05:02,200 --> 00:05:04,080 Speaker 1: as well, not only our blood but even our our 96 00:05:04,160 --> 00:05:06,839 Speaker 1: waste products are kind of parts of us on the 97 00:05:06,839 --> 00:05:08,920 Speaker 1: way out. And as I had mentioned before, we don't 98 00:05:08,960 --> 00:05:10,919 Speaker 1: tend to think about this like what is what's my 99 00:05:11,000 --> 00:05:14,440 Speaker 1: gut microbiota doing right now? Is there any crossover with 100 00:05:14,600 --> 00:05:17,080 Speaker 1: someone I live with? And this is from a new 101 00:05:17,120 --> 00:05:20,799 Speaker 1: York article Roller Derby of Microbiome, the author very Nique 102 00:05:21,200 --> 00:05:24,120 Speaker 1: Greenwood explores the idea of whether or not we colonize 103 00:05:24,160 --> 00:05:28,320 Speaker 1: each other with our own bacteria, specifically with gut bacteria, 104 00:05:28,400 --> 00:05:31,839 Speaker 1: and she talked to Balfour Startur, who is a gastroenterologist 105 00:05:31,839 --> 00:05:34,279 Speaker 1: at the University of from Carolina at Chapple Hill, and 106 00:05:34,320 --> 00:05:38,120 Speaker 1: he specializes in inflammatory bowel disease like crones, and he 107 00:05:38,160 --> 00:05:41,720 Speaker 1: says that there is a growing stack of evidence, some published, 108 00:05:41,880 --> 00:05:46,920 Speaker 1: some not that people who have lived with inflammatory bowel 109 00:05:46,960 --> 00:05:50,239 Speaker 1: disease sufferers for long periods of time had higher rates 110 00:05:50,279 --> 00:05:54,200 Speaker 1: of it themselves than people in the general population. He 111 00:05:54,240 --> 00:05:56,640 Speaker 1: also cited a two thousand seven study that was published 112 00:05:56,640 --> 00:06:01,000 Speaker 1: in the journal Cell in which scientists deliberately transmitted gut 113 00:06:01,000 --> 00:06:05,800 Speaker 1: bacteria of mice genetically predisposed to develop intestinal inflammation to 114 00:06:05,920 --> 00:06:08,520 Speaker 1: healthy mice, and this caused the healthy mice in turn 115 00:06:08,600 --> 00:06:12,080 Speaker 1: to develop the condition. So here we see essentially the 116 00:06:12,120 --> 00:06:17,240 Speaker 1: seating of the condition through a fecal transplant, again changing 117 00:06:17,240 --> 00:06:20,279 Speaker 1: the organism by changing the contents of its bowels. Again, 118 00:06:20,360 --> 00:06:22,800 Speaker 1: this is just um well, not necessarily in the case 119 00:06:22,839 --> 00:06:25,640 Speaker 1: of the mice. But when star Toro was talking about 120 00:06:25,800 --> 00:06:29,320 Speaker 1: more about people just who are living together, uh, who 121 00:06:29,360 --> 00:06:33,400 Speaker 1: have those trace bits of gut bacteria essentially feces being 122 00:06:33,440 --> 00:06:36,920 Speaker 1: exchanged here. So that's just the tiny bit that would 123 00:06:36,960 --> 00:06:41,479 Speaker 1: be colonizing your own microbiota. Yeah, and again colonization is 124 00:06:41,560 --> 00:06:43,120 Speaker 1: key here. I mean, just to throw out a few 125 00:06:43,200 --> 00:06:45,160 Speaker 1: quick stats that we've hit in the past, I mean, 126 00:06:45,160 --> 00:06:47,480 Speaker 1: the human mouth alone contains five hundred to a thousand 127 00:06:47,560 --> 00:06:50,279 Speaker 1: different types of bacteria, and of those, only a hundred 128 00:06:50,360 --> 00:06:52,120 Speaker 1: to two hundred live in a mouth at any given time. 129 00:06:52,160 --> 00:06:54,480 Speaker 1: And that's just a mouth. When you take into account 130 00:06:54,520 --> 00:06:58,320 Speaker 1: the entire human body, Um, it really begins to skew 131 00:06:58,400 --> 00:07:00,800 Speaker 1: the idea of what is an individual and what is 132 00:07:00,880 --> 00:07:03,720 Speaker 1: a a collective. Yeah, because we've talked about this before, 133 00:07:03,720 --> 00:07:06,560 Speaker 1: like we're just host for for bacterial cells when you 134 00:07:06,600 --> 00:07:10,000 Speaker 1: look at how very colonized we are by them. Now, 135 00:07:10,240 --> 00:07:12,640 Speaker 1: we want to talk a little bit about a couple 136 00:07:12,680 --> 00:07:16,240 Speaker 1: of conditions that are very difficult to treat because this 137 00:07:16,280 --> 00:07:19,200 Speaker 1: will actually play into fecal transplants. And the first is 138 00:07:19,240 --> 00:07:23,920 Speaker 1: something called Clostridium deficily or see death if you will, 139 00:07:24,000 --> 00:07:27,160 Speaker 1: death on the streets, and it's a bacterium that releases 140 00:07:27,240 --> 00:07:30,800 Speaker 1: toxins that attack the intestinal lining and cause inflammation of 141 00:07:30,800 --> 00:07:33,480 Speaker 1: the colon, and according to the Centers for Disease Control 142 00:07:33,480 --> 00:07:35,320 Speaker 1: and Prevention, C DIFF is linked to a quarter of 143 00:07:35,320 --> 00:07:38,520 Speaker 1: a million hospitalizations in four deaths a year in the US, 144 00:07:39,040 --> 00:07:43,240 Speaker 1: and deaths from CEDF increased four hundred percent between two 145 00:07:43,240 --> 00:07:46,440 Speaker 1: thousand and two thousand and seven due impart to the 146 00:07:46,480 --> 00:07:51,440 Speaker 1: emergence of a stronger strain. Yeah, this can be especially 147 00:07:51,480 --> 00:07:53,600 Speaker 1: a huge problem for the elderly. UM in some sort 148 00:07:53,600 --> 00:07:55,920 Speaker 1: of a care environment, and just to throw some symptoms 149 00:07:55,920 --> 00:07:59,080 Speaker 1: that you UM, just to know what we're dealing with here. 150 00:07:59,480 --> 00:08:03,520 Speaker 1: You can get more severe infections of C. Deaf causing 151 00:08:03,560 --> 00:08:06,680 Speaker 1: watery diarrhea up to fifteen times per day, severe abdominal pain, 152 00:08:06,760 --> 00:08:10,400 Speaker 1: loss of appetite, fever, blutter, puss in the stool, weight loss, 153 00:08:10,440 --> 00:08:13,680 Speaker 1: and then in extreme cases C. Deaf infection can lead 154 00:08:13,720 --> 00:08:16,520 Speaker 1: to a hole in the intestines, which can be fatal 155 00:08:16,560 --> 00:08:20,760 Speaker 1: if not treated immediately. So is it is this is 156 00:08:20,760 --> 00:08:23,800 Speaker 1: the affection spirals out of control. UM. It can cause 157 00:08:23,960 --> 00:08:25,800 Speaker 1: a lot of major health problems. So this is this 158 00:08:25,880 --> 00:08:28,920 Speaker 1: is not a condition to take lightly. Yeah, and it's 159 00:08:28,920 --> 00:08:32,000 Speaker 1: been associated with hospitals quite a bit because the strain 160 00:08:32,040 --> 00:08:35,360 Speaker 1: that emerged is one that has become antibiotic resistant. And 161 00:08:35,400 --> 00:08:37,720 Speaker 1: so not to scare anybody who may or may not 162 00:08:37,800 --> 00:08:41,800 Speaker 1: have to visit a hospital. But it turns out that 163 00:08:41,960 --> 00:08:44,920 Speaker 1: in an October issue of the American Journal of Infection Control, 164 00:08:45,559 --> 00:08:47,959 Speaker 1: but they reported that the incidents is ce deaf and 165 00:08:48,040 --> 00:08:50,760 Speaker 1: hospitals nearly doubled between two thousand and one and two 166 00:08:50,800 --> 00:08:53,920 Speaker 1: thousand and ten, with mortality increasing from six point six 167 00:08:53,920 --> 00:08:56,920 Speaker 1: percent in two thousand and one to seven two percent 168 00:08:56,960 --> 00:08:59,040 Speaker 1: in two thousand and ten. And again, as you had 169 00:08:59,080 --> 00:09:01,520 Speaker 1: mentioned in the other really this can be terrible. This 170 00:09:01,600 --> 00:09:04,000 Speaker 1: is this is a big blow to the body. Yeah, 171 00:09:04,040 --> 00:09:06,240 Speaker 1: and you know, it's it's interesting just to think about 172 00:09:06,280 --> 00:09:09,440 Speaker 1: antibiotics and their role in this and another condition, another 173 00:09:09,440 --> 00:09:12,520 Speaker 1: condition they're going to talk about and and think again 174 00:09:12,559 --> 00:09:16,160 Speaker 1: about the body is this collective of all this bacteria 175 00:09:16,320 --> 00:09:18,480 Speaker 1: and uh and and and as as well as our 176 00:09:18,520 --> 00:09:22,719 Speaker 1: actual cellular structures and so forth. But in dealing with 177 00:09:22,880 --> 00:09:26,920 Speaker 1: bad bacteria, when you you're using powerful antibiotics, it can 178 00:09:26,920 --> 00:09:29,520 Speaker 1: all it can almost be like carpet bombing a city 179 00:09:29,720 --> 00:09:33,079 Speaker 1: to deal with some sort of insurrection or some sort 180 00:09:33,120 --> 00:09:35,600 Speaker 1: of a crime problem or what have you because you 181 00:09:35,679 --> 00:09:39,280 Speaker 1: end up just laying waste, and sometimes you're creating an 182 00:09:39,280 --> 00:09:44,160 Speaker 1: opportunity for quote unquote bad bacteria to rise up and 183 00:09:44,240 --> 00:09:47,600 Speaker 1: take advantage of the new environment. Yeah, because with those antbiotics, 184 00:09:47,600 --> 00:09:50,480 Speaker 1: you have carpet bombed all the good bacteria. And it 185 00:09:50,480 --> 00:09:53,880 Speaker 1: turns out that in about except for a course of treatment, 186 00:09:53,920 --> 00:09:58,080 Speaker 1: that of first time patients will suffer again. And up 187 00:09:58,120 --> 00:10:01,720 Speaker 1: to sixty percent of patients who have experienced two episodes 188 00:10:01,760 --> 00:10:07,080 Speaker 1: are doomed for another. So there, up until now, and 189 00:10:07,120 --> 00:10:09,320 Speaker 1: we will talk about people transplants and a little bit 190 00:10:09,360 --> 00:10:12,040 Speaker 1: there really wasn't a good course of action to take 191 00:10:12,080 --> 00:10:15,720 Speaker 1: against this, Yeah, because again it just keeps being a problem, 192 00:10:15,760 --> 00:10:19,520 Speaker 1: and so you've destabilized the region and then no matter, 193 00:10:20,000 --> 00:10:23,920 Speaker 1: subsequent carpet bombings don't seem to be helping somehow. Yeah. Now, 194 00:10:24,000 --> 00:10:27,839 Speaker 1: another bacterium reeks quite a bit of havoc and again 195 00:10:27,960 --> 00:10:30,839 Speaker 1: very hard to treat. We're talking about k pneumonia or 196 00:10:30,840 --> 00:10:35,920 Speaker 1: albusiela um. Pneumonia is a type of Gram negative bacteria 197 00:10:35,960 --> 00:10:38,719 Speaker 1: that can cause different types of healthcare associated infections. We're 198 00:10:38,720 --> 00:10:44,640 Speaker 1: talking about pneumonia, bloodstream infections, wound or surgical fight infections, 199 00:10:44,640 --> 00:10:51,640 Speaker 1: and meningitis, and it too has developed antimicrobial resistance and 200 00:10:51,960 --> 00:10:55,960 Speaker 1: recently to the class of antibotics known as carbon panems. 201 00:10:56,000 --> 00:10:58,840 Speaker 1: So this is something that's really hard to treat right now. Yeah, Now, 202 00:10:58,840 --> 00:11:01,040 Speaker 1: it's worth noting that the of the cell of bacteria, 203 00:11:01,160 --> 00:11:04,400 Speaker 1: they're normally found in the human intestines, where they don't 204 00:11:04,440 --> 00:11:06,800 Speaker 1: cause any disease. Where it becomes a problem is when 205 00:11:06,800 --> 00:11:10,800 Speaker 1: they enter the respiratory tract to cause this pneumonia or 206 00:11:10,960 --> 00:11:14,800 Speaker 1: the or the blood to cause a bloodstream infection. The 207 00:11:14,840 --> 00:11:17,640 Speaker 1: thing about this is that as debilitating as they are, 208 00:11:18,240 --> 00:11:23,400 Speaker 1: it is known that fecal transplants can vanquish these And 209 00:11:23,400 --> 00:11:25,200 Speaker 1: we're gonna take a quick print when we get back. 210 00:11:25,400 --> 00:11:27,600 Speaker 1: We're going to talk about how all this goes down. 211 00:11:34,920 --> 00:11:38,160 Speaker 1: All right, we're back, and yes, we're talking about vecal transplants, 212 00:11:38,280 --> 00:11:41,880 Speaker 1: or to use the more official term, fecal microbiotic transplantation 213 00:11:42,000 --> 00:11:45,120 Speaker 1: or f e m T. That's right, And uh, you know, 214 00:11:45,160 --> 00:11:46,800 Speaker 1: we kind of touched on this. We tend to think 215 00:11:46,800 --> 00:11:50,840 Speaker 1: of our do is just purely waste material, but by weight, 216 00:11:51,040 --> 00:11:55,720 Speaker 1: sixty of our stool is bacteria. And we're talking about rich, 217 00:11:56,600 --> 00:12:00,760 Speaker 1: beneficial stew of bacteria in a healthy individual. All, yes, 218 00:12:00,840 --> 00:12:06,720 Speaker 1: that that turd is is alive there. Um, when when 219 00:12:06,760 --> 00:12:11,040 Speaker 1: my son personifies the his waist and calls it a 220 00:12:11,080 --> 00:12:14,280 Speaker 1: mama or a daddy pooh or something often baby poos, 221 00:12:14,840 --> 00:12:18,000 Speaker 1: So they tend to come late in the movement. Um, 222 00:12:18,040 --> 00:12:21,800 Speaker 1: he's he's really not too far off the off the chart. Um. 223 00:12:21,840 --> 00:12:24,280 Speaker 1: And so the idea here, I think this is one 224 00:12:24,320 --> 00:12:26,280 Speaker 1: of those ideas just to to to rond a little bit. 225 00:12:26,320 --> 00:12:28,240 Speaker 1: You know, when when you when you get past the 226 00:12:28,480 --> 00:12:32,960 Speaker 1: shock headlines and the jokes, it really makes a tremendous 227 00:12:32,960 --> 00:12:36,000 Speaker 1: amount of sense, Like there's nothing really that wild or 228 00:12:36,000 --> 00:12:39,560 Speaker 1: crazy or horrific about it. Um. You know, we've thrown 229 00:12:39,840 --> 00:12:42,800 Speaker 1: articles about people transplants up on our Facebook page before, 230 00:12:43,120 --> 00:12:45,079 Speaker 1: and we have a number of Facebook followers, and we 231 00:12:45,120 --> 00:12:47,480 Speaker 1: have some some very bright bulbs out there, and some 232 00:12:47,520 --> 00:12:49,760 Speaker 1: people who are just you know, getting their their hands 233 00:12:49,800 --> 00:12:52,360 Speaker 1: around some science and as well, I mean people of 234 00:12:52,360 --> 00:12:55,160 Speaker 1: all ages and greeds and and some people you know, 235 00:12:55,200 --> 00:12:56,959 Speaker 1: react very viscerally to that. They're like, oh god, I 236 00:12:56,960 --> 00:12:59,760 Speaker 1: would never do that. That's that's horrible, that's disgusting sounding. 237 00:13:00,040 --> 00:13:02,440 Speaker 1: But but that's just the surface. Let when you actually 238 00:13:02,440 --> 00:13:03,920 Speaker 1: get into the science of it when you when you 239 00:13:03,960 --> 00:13:07,520 Speaker 1: look at yourself not as this singular individual, but as 240 00:13:07,559 --> 00:13:11,040 Speaker 1: this this colony of bacteria. It makes perfect sense that 241 00:13:11,120 --> 00:13:15,160 Speaker 1: you would deal with this imbalance by by by bringing 242 00:13:15,160 --> 00:13:19,280 Speaker 1: balance in with a healthy um stool sample and implant 243 00:13:19,320 --> 00:13:22,800 Speaker 1: that or somehow get that to the bowels. Well, but 244 00:13:22,920 --> 00:13:25,720 Speaker 1: first you have to get over the idea of pumping 245 00:13:25,920 --> 00:13:29,960 Speaker 1: into your colon someone else's poop, right, right, So if 246 00:13:30,000 --> 00:13:32,840 Speaker 1: you think about it more like this, Hey, it's a 247 00:13:32,880 --> 00:13:35,800 Speaker 1: treatment that's done by a colonoscopy. A lot of people 248 00:13:35,960 --> 00:13:39,599 Speaker 1: have colonoscopies, right to's scary about that? I mean you 249 00:13:39,600 --> 00:13:42,480 Speaker 1: shouldn't be. I mean, it's just it's an orifice. It's 250 00:13:42,520 --> 00:13:44,360 Speaker 1: an orifice. There's a way and there's a way out, 251 00:13:44,440 --> 00:13:47,000 Speaker 1: and sometimes you're gonna let professionals go in there. It's 252 00:13:47,000 --> 00:13:50,800 Speaker 1: just how it works. It involves anesthesia or at least adation. 253 00:13:51,520 --> 00:13:55,280 Speaker 1: There's a full bowel clean out previous to a f 254 00:13:55,520 --> 00:14:00,200 Speaker 1: MT in a limited diet prior to the procedure out. 255 00:14:00,600 --> 00:14:03,560 Speaker 1: How this all goes down is you get a healthy 256 00:14:03,679 --> 00:14:07,840 Speaker 1: stool sample. That's key. They're not just grabbing anybody. Yeah, 257 00:14:08,200 --> 00:14:10,160 Speaker 1: like you you know, in the past, I think it 258 00:14:10,480 --> 00:14:13,400 Speaker 1: was done more like, hey, maybe my brother or uncle 259 00:14:13,559 --> 00:14:16,920 Speaker 1: give me a little sample, and you know that they're healthy. 260 00:14:16,920 --> 00:14:19,720 Speaker 1: And then of course the stool gets sampled later to 261 00:14:19,760 --> 00:14:22,560 Speaker 1: make sure that it's healthy. Yeah, it gets betted anyway, 262 00:14:22,600 --> 00:14:25,120 Speaker 1: stool samples mixed with sailing and then pumped into the 263 00:14:25,120 --> 00:14:29,160 Speaker 1: colon and then, as you say, the end result, uh, 264 00:14:29,480 --> 00:14:32,880 Speaker 1: is a rebalance of gut flora that can eradicate the 265 00:14:32,960 --> 00:14:35,800 Speaker 1: seed diff because on its own, your gut flora has 266 00:14:35,840 --> 00:14:39,040 Speaker 1: been demolished. It cannot it just can't stand up to 267 00:14:39,080 --> 00:14:41,960 Speaker 1: the sea diff. But someone else's, which is quite hardy, 268 00:14:42,160 --> 00:14:45,680 Speaker 1: can really do a lot of damage to c DIFF. Now, 269 00:14:45,680 --> 00:14:48,280 Speaker 1: I also want to add that the mixture can also 270 00:14:48,360 --> 00:14:52,280 Speaker 1: be fed via a naso gastric tube. So this is 271 00:14:52,400 --> 00:14:55,720 Speaker 1: the one that that goes in through the nasal passage 272 00:14:55,760 --> 00:14:58,680 Speaker 1: and down the throat and down into the stomach. But again, 273 00:14:58,800 --> 00:15:01,800 Speaker 1: rather different than poop. Just thing, don't it's it's hard 274 00:15:01,840 --> 00:15:04,040 Speaker 1: not to hear that and not think they're gonna put 275 00:15:04,040 --> 00:15:07,360 Speaker 1: poop in my nose. I know it's impossible to to 276 00:15:07,400 --> 00:15:11,640 Speaker 1: get past the revulsion of that and the comedic value 277 00:15:11,640 --> 00:15:14,520 Speaker 1: of that, but uh, you know, again, it's just an orifice. 278 00:15:14,560 --> 00:15:17,000 Speaker 1: It's a way into the inner workings of your body. 279 00:15:17,120 --> 00:15:20,480 Speaker 1: It's actually a bit trickier than a colonoscopy, like doing 280 00:15:20,480 --> 00:15:24,440 Speaker 1: it through through your bum um. So even though some 281 00:15:24,480 --> 00:15:27,000 Speaker 1: people might be put off by the idea of a colonoscopy, 282 00:15:27,120 --> 00:15:29,760 Speaker 1: it's probably the better way to go. Now. Just to 283 00:15:29,800 --> 00:15:32,920 Speaker 1: give you an example of of what sort of effect 284 00:15:32,960 --> 00:15:35,880 Speaker 1: it has and how quickly it takes effect, the Mayo 285 00:15:35,960 --> 00:15:39,800 Speaker 1: Clinic in Arizona that their fm T team first performed 286 00:15:39,880 --> 00:15:41,560 Speaker 1: a fecal transplant in two thousand and eleven for a 287 00:15:41,600 --> 00:15:45,880 Speaker 1: patient with severe c diff And of course this stool 288 00:15:45,960 --> 00:15:50,560 Speaker 1: was from the brother and according to Robert Ornstein of 289 00:15:50,600 --> 00:15:53,000 Speaker 1: the Mayo Clinic, he says, unbelievably, the patient left the 290 00:15:53,040 --> 00:15:56,160 Speaker 1: hospital twenty four hours after the procedure after having them 291 00:15:56,320 --> 00:15:59,360 Speaker 1: bedridden for weeks. That is how effective this treatment is. 292 00:16:00,080 --> 00:16:02,400 Speaker 1: D there and there are plenty of examples of success stories. 293 00:16:02,400 --> 00:16:04,280 Speaker 1: This is not one of those things where you know, 294 00:16:04,320 --> 00:16:07,760 Speaker 1: they say, well, one person used this crazy technique and 295 00:16:07,960 --> 00:16:10,000 Speaker 1: it happened to work in this one instance, but it 296 00:16:10,040 --> 00:16:12,400 Speaker 1: hasn't really been vetted. We've seen we've seen account after 297 00:16:12,440 --> 00:16:16,760 Speaker 1: account of of f m T s producing results restoring 298 00:16:16,760 --> 00:16:21,120 Speaker 1: the balance to two bows. That are plagued by by 299 00:16:21,160 --> 00:16:23,720 Speaker 1: these conditions that we've discussed. In fact, just to to 300 00:16:23,760 --> 00:16:26,920 Speaker 1: go back to the K pneumonia, just last month here 301 00:16:26,920 --> 00:16:32,200 Speaker 1: in UM at the Jefferson University Hospital in Philadelphia, they 302 00:16:32,200 --> 00:16:35,240 Speaker 1: treated a thirteen year old girl who who had this 303 00:16:35,280 --> 00:16:38,320 Speaker 1: condition with a feel microbiotic transplant and they used it 304 00:16:38,320 --> 00:16:40,560 Speaker 1: to successfully clear the infection. Yeah, and we will not 305 00:16:40,600 --> 00:16:43,520 Speaker 1: go through the litany of things that happened to her 306 00:16:43,600 --> 00:16:46,960 Speaker 1: because of K pneumonia, but it was I mean, she 307 00:16:47,080 --> 00:16:51,240 Speaker 1: was suffering greatly because it was just one thing after another. Now, 308 00:16:51,520 --> 00:16:54,720 Speaker 1: I think another good marker of this being a success 309 00:16:54,880 --> 00:16:58,280 Speaker 1: is the fact that someone is monetizing it. And when 310 00:16:58,320 --> 00:17:01,720 Speaker 1: I say someone, I'm talking about a company called open Biome. 311 00:17:02,240 --> 00:17:05,919 Speaker 1: It was that's biom bio Emy. It was launched in 312 00:17:05,960 --> 00:17:10,399 Speaker 1: two twelve and it is the only independent nonprofit school 313 00:17:10,480 --> 00:17:13,639 Speaker 1: bank in the country in the US. It is the 314 00:17:13,640 --> 00:17:17,200 Speaker 1: brainchild of m I T post doc associate Mark Smith. 315 00:17:17,840 --> 00:17:20,560 Speaker 1: And what they do is they collect, test and provide 316 00:17:20,920 --> 00:17:26,280 Speaker 1: becal samples too hospitals and thirty three states for these 317 00:17:26,480 --> 00:17:29,480 Speaker 1: f m T s. Yeah, I was looking around and 318 00:17:29,520 --> 00:17:33,520 Speaker 1: it looks like the prices currently you're looking at two 319 00:17:33,920 --> 00:17:36,720 Speaker 1: fifty per sample of the poop. And again that's vetted poop. 320 00:17:36,760 --> 00:17:39,000 Speaker 1: This is good stuff, this is premot poop, and this 321 00:17:39,160 --> 00:17:41,359 Speaker 1: is what the hospital would pay for it. Yeah. Yeah, 322 00:17:41,400 --> 00:17:44,000 Speaker 1: you can't really go to the website in order or 323 00:17:44,400 --> 00:17:47,000 Speaker 1: or certainly don't binding off Amazon if it looks like 324 00:17:47,040 --> 00:17:50,560 Speaker 1: someone's selling it. Um. Yes, So that's a two fifty 325 00:17:50,560 --> 00:17:54,119 Speaker 1: million lead sample of a fecal microbota prepared for lower 326 00:17:54,160 --> 00:17:57,399 Speaker 1: transplant delivery, which we already talked about, or a thirty 327 00:17:57,440 --> 00:18:01,119 Speaker 1: million leader sample for the upper trans planned delivery again 328 00:18:01,200 --> 00:18:03,879 Speaker 1: through the nasal passage and down in the stomach. The 329 00:18:03,960 --> 00:18:08,080 Speaker 1: person who donates the poop, well, they're paid forty for 330 00:18:08,200 --> 00:18:12,760 Speaker 1: each deposit. Now, if you want to become a paid 331 00:18:12,800 --> 00:18:16,800 Speaker 1: donor to open biome, you have to undergo really thorough screenings. 332 00:18:16,840 --> 00:18:21,280 Speaker 1: Of course, we're talking about question health history with a 333 00:18:21,359 --> 00:18:25,800 Speaker 1: physician to a travel history analysis, and of course recent 334 00:18:25,880 --> 00:18:28,399 Speaker 1: use of antibotics, because if you've used antibotics, and you're 335 00:18:28,400 --> 00:18:31,320 Speaker 1: probably not a contender, right right, because you've carpet bombed 336 00:18:31,359 --> 00:18:34,960 Speaker 1: the civilization that's producing the poop that they're interested in. 337 00:18:35,320 --> 00:18:36,959 Speaker 1: I like how this could be a real game changer 338 00:18:37,080 --> 00:18:40,679 Speaker 1: in um UM College dudes making a little extra money, like, 339 00:18:40,720 --> 00:18:42,880 Speaker 1: no longer do they have to I would not restrict 340 00:18:42,880 --> 00:18:44,919 Speaker 1: it to the dudes. Oh well, that's true, that's right. 341 00:18:44,960 --> 00:18:46,359 Speaker 1: I mean I was just thinking about it in terms 342 00:18:46,359 --> 00:18:48,639 Speaker 1: of sperm donation. Of course, the other side of that 343 00:18:48,720 --> 00:18:53,440 Speaker 1: being egg donation. But but the poop donation easier than both. Well, 344 00:18:53,440 --> 00:18:55,080 Speaker 1: I mean it's great. It's like again, it's kind of 345 00:18:55,080 --> 00:18:58,240 Speaker 1: again like a blood bank donation, although you're getting paid 346 00:18:58,280 --> 00:19:01,800 Speaker 1: for this now one waste material anyway, right, what are 347 00:19:01,800 --> 00:19:03,880 Speaker 1: you gonna deal with it? It's gonna flush it um. 348 00:19:03,960 --> 00:19:06,639 Speaker 1: Once a donor sample is reviewed by a lab for 349 00:19:06,680 --> 00:19:09,639 Speaker 1: any infectious agents in the health of the bacteria. The 350 00:19:09,680 --> 00:19:13,320 Speaker 1: donor's blood is then tested for standard blood borne diseases 351 00:19:13,320 --> 00:19:17,280 Speaker 1: we're talking about hepatis, ABC, syphilis, HIV, AIDS, and then 352 00:19:17,440 --> 00:19:21,160 Speaker 1: finally you can progress to the actual physical donation part 353 00:19:21,160 --> 00:19:22,760 Speaker 1: of it all. Yeah. Again, so you can think about 354 00:19:22,760 --> 00:19:24,800 Speaker 1: it in terms of any kind of blood or tissue, 355 00:19:25,200 --> 00:19:28,240 Speaker 1: uh sample that is that is taken and then reused 356 00:19:28,240 --> 00:19:31,320 Speaker 1: and sort of transplant environment. Is it's going to be vetted, 357 00:19:31,320 --> 00:19:33,560 Speaker 1: it's gonna they're gonna look for all these various diseases 358 00:19:34,600 --> 00:19:39,080 Speaker 1: before it ever takes that it's the saline blended form. Now, 359 00:19:39,119 --> 00:19:40,879 Speaker 1: one of the one of the things about this it 360 00:19:40,960 --> 00:19:43,480 Speaker 1: leads you to the question of like how good is 361 00:19:43,520 --> 00:19:46,520 Speaker 1: that poop sample? You know, Like then you begin to 362 00:19:46,560 --> 00:19:48,920 Speaker 1: really sort of great. And I'm sure, right, I'm sure 363 00:19:48,960 --> 00:19:51,239 Speaker 1: that lab is like, this is great. It's got so 364 00:19:51,320 --> 00:19:56,720 Speaker 1: much beneficial gut flora in it. But there's one researcher 365 00:19:56,720 --> 00:19:59,560 Speaker 1: who really took this to the extreme, and I'm talking 366 00:19:59,640 --> 00:20:05,560 Speaker 1: about hunting down artisanal hunter gatherer poop. Now, this is 367 00:20:05,600 --> 00:20:09,439 Speaker 1: from the first paragraph of a Popular Science article by 368 00:20:09,480 --> 00:20:12,639 Speaker 1: Emily Gertz, writing about the scientists who traveled around the 369 00:20:12,640 --> 00:20:16,879 Speaker 1: world to give himself an f MT essentially, and it 370 00:20:16,880 --> 00:20:19,760 Speaker 1: goes a little like this. This is him writing, quote, 371 00:20:19,800 --> 00:20:23,879 Speaker 1: as the sunset over a lake aase in Tanzania, nearly 372 00:20:23,960 --> 00:20:26,240 Speaker 1: thirty minutes had passed since I hadn't served at a 373 00:20:26,240 --> 00:20:29,679 Speaker 1: turkey baster into my bum and injected the feces of 374 00:20:29,720 --> 00:20:32,240 Speaker 1: the heads a man, a member of one of the 375 00:20:32,320 --> 00:20:35,639 Speaker 1: last remaining hunter gatherer tribes in the world, into the 376 00:20:35,680 --> 00:20:39,720 Speaker 1: nether regions of my distal colon. Indeed, those are the 377 00:20:39,760 --> 00:20:42,800 Speaker 1: words of Jeff Leach Lee, and he at this point 378 00:20:42,840 --> 00:20:44,359 Speaker 1: It's important to know that he'd been living with the 379 00:20:44,400 --> 00:20:47,399 Speaker 1: hasda uh, these hunter gathers for for over a year. 380 00:20:47,600 --> 00:20:49,679 Speaker 1: He was he was immersed in their culture, and he 381 00:20:49,760 --> 00:20:52,879 Speaker 1: was His prime motivation, he claims, was to study quote 382 00:20:53,080 --> 00:20:57,480 Speaker 1: microbial extinction, uh, something I believe we suffer from in 383 00:20:57,520 --> 00:20:59,760 Speaker 1: the Western world and maybe at the root of what's 384 00:20:59,800 --> 00:21:02,560 Speaker 1: making a six. So the idea here is he's interested 385 00:21:02,640 --> 00:21:08,439 Speaker 1: in these people's um microbiota in their stool because they 386 00:21:08,640 --> 00:21:11,560 Speaker 1: perhaps they have things that we no longer have because 387 00:21:11,560 --> 00:21:14,480 Speaker 1: we've been carpet bombing our our stool for so long 388 00:21:14,480 --> 00:21:19,000 Speaker 1: with antibiotics that we don't even have a natural sample 389 00:21:19,080 --> 00:21:21,440 Speaker 1: to turn to in the world around us. That's his 390 00:21:21,440 --> 00:21:24,560 Speaker 1: his curiosity, his his argument. Yeah, Now the heads are 391 00:21:25,080 --> 00:21:28,040 Speaker 1: um wandering foragers and they eat a diet of roots, 392 00:21:28,080 --> 00:21:30,080 Speaker 1: berries and game. Okay, this is one of the reasons 393 00:21:30,119 --> 00:21:32,400 Speaker 1: why he was interested, because they don't have the influences 394 00:21:32,440 --> 00:21:36,359 Speaker 1: of the Western world. Now. According to the study, which 395 00:21:36,400 --> 00:21:39,919 Speaker 1: compared stool samples from sixteen Italian urban nights and twenty 396 00:21:40,000 --> 00:21:43,480 Speaker 1: seven heads of foragers of both genders, the heads of 397 00:21:43,640 --> 00:21:47,240 Speaker 1: guts are home to a microbial community unlike anything that's 398 00:21:47,280 --> 00:21:51,679 Speaker 1: been seen before. In a modern human population. And the 399 00:21:51,720 --> 00:21:54,080 Speaker 1: idea is that perhaps the gut floor is what the 400 00:21:54,200 --> 00:21:58,680 Speaker 1: human gut microbiome looked like before our ancestors figured out 401 00:21:58,920 --> 00:22:02,120 Speaker 1: to farm about twelve thousand years ago. So again, he's 402 00:22:02,200 --> 00:22:05,080 Speaker 1: very interested in seeing what the sort of set point 403 00:22:05,920 --> 00:22:10,240 Speaker 1: is before all these other influences began to change our diets. 404 00:22:10,320 --> 00:22:14,800 Speaker 1: Primordial pop if you will, poop Alyssa curtaindon she's a 405 00:22:14,920 --> 00:22:18,600 Speaker 1: nutritional anthropologist from the University of Nevada Las Vegas, says quote, 406 00:22:18,640 --> 00:22:21,480 Speaker 1: many of the bacteria are species that the researchers had 407 00:22:21,560 --> 00:22:25,280 Speaker 1: never seen before, and even familiar microbes were present in 408 00:22:25,560 --> 00:22:30,600 Speaker 1: unusual levels and the hads of belly. So I start 409 00:22:30,640 --> 00:22:34,480 Speaker 1: to think about this, like if you began to extrapolate 410 00:22:34,520 --> 00:22:37,719 Speaker 1: this or normalize it, then you can see how stool 411 00:22:37,800 --> 00:22:42,359 Speaker 1: samples might be divided into different price points, as I 412 00:22:42,440 --> 00:22:45,760 Speaker 1: had said, depending on the donor's dietary profile. It's kind 413 00:22:45,760 --> 00:22:47,920 Speaker 1: of like you might be able to flip through a book, right, 414 00:22:48,240 --> 00:22:53,240 Speaker 1: just like a donor book and um, and then if 415 00:22:53,240 --> 00:22:56,359 Speaker 1: you especially if it continues to bear out that gut 416 00:22:56,400 --> 00:23:00,520 Speaker 1: flora can influence anything from like Parkinson's dissay ease to 417 00:23:00,880 --> 00:23:05,040 Speaker 1: obesity you may see this normalized to such a degree 418 00:23:05,080 --> 00:23:09,640 Speaker 1: that people are willingly undergoing f m T suh. Not 419 00:23:09,720 --> 00:23:12,520 Speaker 1: because they're in pain and they have something like c DIFF, 420 00:23:12,640 --> 00:23:15,359 Speaker 1: but because maybe they just want to try to lose weight, 421 00:23:15,480 --> 00:23:19,240 Speaker 1: or maybe they even feel like it would rebalance there 422 00:23:20,440 --> 00:23:24,360 Speaker 1: their emotional states. Yeah, because as we discussed before, I mean, 423 00:23:24,760 --> 00:23:27,480 Speaker 1: the mind does not exist in its own little bubble 424 00:23:27,520 --> 00:23:29,760 Speaker 1: out here in the ether. H. It's not piped into 425 00:23:29,800 --> 00:23:31,879 Speaker 1: us from some external soul. That the way that we 426 00:23:31,960 --> 00:23:34,240 Speaker 1: think every day, the way we interact with their environment, 427 00:23:34,280 --> 00:23:35,960 Speaker 1: it's all depending on what's going on in the body 428 00:23:36,000 --> 00:23:38,080 Speaker 1: as a whole. So yeah, it would make I could, 429 00:23:38,119 --> 00:23:40,600 Speaker 1: I could easily see that that reality coming about. Yeah, 430 00:23:40,640 --> 00:23:42,400 Speaker 1: and we we even have an episode I think it's 431 00:23:42,440 --> 00:23:45,000 Speaker 1: called as the gut, the second brain, that goes more 432 00:23:45,080 --> 00:23:48,800 Speaker 1: into this idea of our guts regulating our moods. But 433 00:23:48,960 --> 00:23:52,320 Speaker 1: of course all of this um, this idea of taking 434 00:23:52,320 --> 00:23:55,120 Speaker 1: of just willingly doing a f m T is dependent 435 00:23:55,200 --> 00:23:59,240 Speaker 1: on that normalization factor. And what is more normal than 436 00:23:59,280 --> 00:24:01,480 Speaker 1: taking a pill? Yeah, I mean it's here in the 437 00:24:01,720 --> 00:24:05,120 Speaker 1: modern Western world espectially, we love taking pills. We don't 438 00:24:05,119 --> 00:24:07,159 Speaker 1: even care what what's in it. We'll take it. Just 439 00:24:07,240 --> 00:24:09,080 Speaker 1: give it to us. You say we can treat something 440 00:24:09,080 --> 00:24:12,440 Speaker 1: with a pill, great, give me four of them. So so, yes, 441 00:24:12,920 --> 00:24:16,960 Speaker 1: some scientists have been looking into ways to take f 442 00:24:17,119 --> 00:24:20,560 Speaker 1: MT and get it away from the UH, the Turkey 443 00:24:20,600 --> 00:24:26,560 Speaker 1: based nasal UH to being um conoscopy route and getting 444 00:24:26,560 --> 00:24:29,679 Speaker 1: more into something that is UH that is more medicinal 445 00:24:30,080 --> 00:24:34,240 Speaker 1: UH in form and so a study published in October 446 00:24:34,359 --> 00:24:36,560 Speaker 1: this year to fourteen in the Journal of the American 447 00:24:36,600 --> 00:24:40,840 Speaker 1: Medical Association showed that the ingestion of frozen fecal matter 448 00:24:41,160 --> 00:24:46,159 Speaker 1: contained in capsules resulted in a success rate among subjects 449 00:24:46,200 --> 00:24:51,080 Speaker 1: suffering from recurring seed death infections. So it's the idea, 450 00:24:51,440 --> 00:24:54,000 Speaker 1: you freeze it, put in the capsule and then send 451 00:24:54,000 --> 00:24:55,440 Speaker 1: it on its way. I mean, it's taken the same 452 00:24:55,520 --> 00:24:59,000 Speaker 1: route as those those nasal upper transplant to delivery system. 453 00:24:59,080 --> 00:25:02,639 Speaker 1: So why not. Yeah, And again we're talking about fecal 454 00:25:02,720 --> 00:25:06,560 Speaker 1: matter that was you know, surveyed, and it was sampled 455 00:25:06,600 --> 00:25:09,359 Speaker 1: and made to be sure that it was healthy, and 456 00:25:09,600 --> 00:25:12,439 Speaker 1: once it was capsulized, it was that was given to 457 00:25:12,480 --> 00:25:15,800 Speaker 1: the subject. They were giving fifteen capsules on two consecutive 458 00:25:15,880 --> 00:25:19,359 Speaker 1: days and then observed for up to six months. And 459 00:25:19,520 --> 00:25:21,960 Speaker 1: now This gets really granular here. It says their daily 460 00:25:22,040 --> 00:25:25,160 Speaker 1: number of bowel movements dropped from a median of five 461 00:25:25,200 --> 00:25:28,119 Speaker 1: a day prior to the first capsule to two on 462 00:25:28,240 --> 00:25:31,480 Speaker 1: day three and one at week eight, And it says 463 00:25:31,480 --> 00:25:34,800 Speaker 1: subjects experienced no serious side effects. So it's kind of 464 00:25:34,840 --> 00:25:38,919 Speaker 1: a no brainer, right, because you're talking about capsules taken, 465 00:25:39,080 --> 00:25:41,720 Speaker 1: you know, a couple of minutes a day, as opposed 466 00:25:41,760 --> 00:25:45,879 Speaker 1: to a colonoscopy, which is an actual medical procedure. Okay, 467 00:25:46,200 --> 00:25:49,000 Speaker 1: all right, so we get into a pill form. Um, 468 00:25:49,080 --> 00:25:52,200 Speaker 1: we we get past the jokes and the shock headlines. 469 00:25:52,240 --> 00:25:55,120 Speaker 1: We get a better understanding of how our bodies work 470 00:25:55,160 --> 00:25:58,600 Speaker 1: and the importance of our microbiota. UM. Maybe we were 471 00:25:58,640 --> 00:26:00,719 Speaker 1: even rebranded at some point, the cause you still have 472 00:26:01,000 --> 00:26:02,840 Speaker 1: vecal in the title. Yeah, what do you want to 473 00:26:02,880 --> 00:26:05,159 Speaker 1: rebrand it? Um? You know, I feel like if we 474 00:26:05,160 --> 00:26:08,800 Speaker 1: were to rebrand it from vecal microbiotic transplantation to uh, 475 00:26:08,920 --> 00:26:13,320 Speaker 1: something like intestinal microbiotic transplantation. I don't know if if 476 00:26:13,359 --> 00:26:15,320 Speaker 1: that would work, but like that would be I think 477 00:26:15,320 --> 00:26:16,800 Speaker 1: that would soften the blow a little bit. I M 478 00:26:16,880 --> 00:26:21,720 Speaker 1: T I MT maybe a b MT. Yeah, we could 479 00:26:21,720 --> 00:26:23,119 Speaker 1: just get bowl in there. I think we could do. 480 00:26:23,119 --> 00:26:25,600 Speaker 1: But I feel like bowel has really entered into the 481 00:26:25,720 --> 00:26:28,680 Speaker 1: vernacular or just in a positive off there and just 482 00:26:28,720 --> 00:26:31,320 Speaker 1: call it a microbiot a transplantation, an empty Okay, I 483 00:26:31,320 --> 00:26:33,359 Speaker 1: think we've got our thing, you know, the whole like 484 00:26:33,760 --> 00:26:36,280 Speaker 1: you know, get rich quick team that we've been looking for. 485 00:26:36,520 --> 00:26:38,480 Speaker 1: I think this is we apply for that small loan 486 00:26:39,280 --> 00:26:41,520 Speaker 1: and then we start just marketing these I m T 487 00:26:41,720 --> 00:26:44,000 Speaker 1: s out of the house stuff works office. I think 488 00:26:44,040 --> 00:26:46,320 Speaker 1: there's only one additional thing standing in our way. What's that? 489 00:26:46,600 --> 00:26:52,240 Speaker 1: That's the Federal Drug Administration. Yeah, because the FDA is 490 00:26:52,320 --> 00:26:55,280 Speaker 1: still has yet to really get behind this as of 491 00:26:55,320 --> 00:26:58,200 Speaker 1: this recording. As you're listening to this in two thousand fourteen, 492 00:26:58,359 --> 00:27:00,760 Speaker 1: past this point, I mean, hopefully that the reality will 493 00:27:00,800 --> 00:27:03,320 Speaker 1: change somewhat, but you know, they have a number of 494 00:27:03,359 --> 00:27:07,879 Speaker 1: concerns because we're talking about a waste product being reutilized 495 00:27:08,600 --> 00:27:11,520 Speaker 1: for use as a medicine, and they have a number 496 00:27:11,560 --> 00:27:14,240 Speaker 1: of concerns about that. Yeah. In two thousand and eleven, 497 00:27:14,240 --> 00:27:17,040 Speaker 1: when we first covered this topic, there there are a 498 00:27:17,080 --> 00:27:19,119 Speaker 1: lot of naysayers out there saying it's not going to 499 00:27:19,200 --> 00:27:22,359 Speaker 1: come to market because it's actually the cheaper version of 500 00:27:22,400 --> 00:27:24,800 Speaker 1: trying to treat something, even though it's the more effective 501 00:27:24,800 --> 00:27:27,360 Speaker 1: one and it's not going to get monetized. But here 502 00:27:27,359 --> 00:27:29,840 Speaker 1: we are in two thousand and fourteen and we see, 503 00:27:30,680 --> 00:27:33,320 Speaker 1: you know, now there's a pill form and it seems 504 00:27:33,400 --> 00:27:35,679 Speaker 1: to be moving forward. So I feel like it's just 505 00:27:35,760 --> 00:27:39,360 Speaker 1: a matter of time. Robert Ornstein's I'm just gonna read 506 00:27:39,400 --> 00:27:42,080 Speaker 1: this little bit from him. He says that the microbiome 507 00:27:42,119 --> 00:27:45,280 Speaker 1: of the gut is not inactive. It's diverse and plays 508 00:27:45,320 --> 00:27:47,399 Speaker 1: many roles in health and well being that are just 509 00:27:47,520 --> 00:27:51,480 Speaker 1: now being explored with molecular biology and the sequencing of 510 00:27:51,520 --> 00:27:54,399 Speaker 1: these species. This can only get bigger. It's like the 511 00:27:54,440 --> 00:27:57,920 Speaker 1: beginning of the space program. And I say, here here 512 00:27:57,960 --> 00:27:59,800 Speaker 1: to that. Indeed, and you know, and we're gonna We're 513 00:27:59,800 --> 00:28:01,760 Speaker 1: gonn continue to have studies are gonna come out about this. 514 00:28:01,760 --> 00:28:04,000 Speaker 1: They're going to be more long term studies about that. 515 00:28:04,000 --> 00:28:07,199 Speaker 1: That's one of the the reasons that has often been cited, 516 00:28:07,320 --> 00:28:10,160 Speaker 1: UH concerning the FDA's concerns is that we don't have 517 00:28:10,280 --> 00:28:15,399 Speaker 1: long term studies and potential side effects of of stool transplantation. UM. 518 00:28:15,480 --> 00:28:17,359 Speaker 1: But but we'll see, like I say, is it's I 519 00:28:17,359 --> 00:28:20,320 Speaker 1: think it's all going to come out in the end. Well, 520 00:28:21,800 --> 00:28:23,879 Speaker 1: I didn't even mean to do that. Yeah, it was beautiful. 521 00:28:24,280 --> 00:28:26,160 Speaker 1: Of course. One of the most exciting things I think 522 00:28:26,160 --> 00:28:28,520 Speaker 1: it's come out of this is a little product called 523 00:28:28,560 --> 00:28:31,880 Speaker 1: pooper RONI whoa are you talking about poop sausage? Yeah? 524 00:28:31,920 --> 00:28:35,600 Speaker 1: I am all right, Well, um, when is this coming 525 00:28:35,640 --> 00:28:41,560 Speaker 1: to market? Never? Well, you know, there's weirdly, there doesn't 526 00:28:41,560 --> 00:28:45,720 Speaker 1: seem to be any companies buying for this process, this 527 00:28:45,720 --> 00:28:51,080 Speaker 1: this bacterial fermenting of sausage using fecal matter. Yeah, despite 528 00:28:51,120 --> 00:28:54,520 Speaker 1: the fact that probiotics are a big deal, right, A 529 00:28:54,560 --> 00:28:59,360 Speaker 1: probiotics yogurt is a big deal. Want why not poop 530 00:28:59,400 --> 00:29:02,680 Speaker 1: sausage exactly? And that's what a bunch of scientists in 531 00:29:02,760 --> 00:29:05,320 Speaker 1: Spain reasons when they were trying to say, hey, maybe 532 00:29:05,360 --> 00:29:10,960 Speaker 1: we could introduce this probiotic profile to fermented sausage because 533 00:29:10,960 --> 00:29:14,360 Speaker 1: we use bacterial fermentation. We've did a whole episode on 534 00:29:14,480 --> 00:29:17,520 Speaker 1: fermenting and uh and and what's involved there? So we 535 00:29:17,720 --> 00:29:19,960 Speaker 1: use these these in the preparation of our food. That's 536 00:29:19,960 --> 00:29:22,480 Speaker 1: no big mystery, that's no revelation. And they said, yeah, 537 00:29:22,480 --> 00:29:25,360 Speaker 1: there's two kinds of bacteria used most often in probiotics, 538 00:29:25,400 --> 00:29:28,480 Speaker 1: and they're far more abundant and infant poop than an 539 00:29:28,520 --> 00:29:33,480 Speaker 1: adult poop. And hey, they thought scratch head a lot 540 00:29:33,600 --> 00:29:35,560 Speaker 1: easier to get. You can just get it out of 541 00:29:35,560 --> 00:29:39,400 Speaker 1: the diaper, right, Yeah, and lo and behold these food 542 00:29:39,440 --> 00:29:44,880 Speaker 1: microbiologists at Calonia's Institute of Food and Agriculture Research in Spain. 543 00:29:45,160 --> 00:29:47,800 Speaker 1: They absconded with the poop. I say, I'm just counted. 544 00:29:48,600 --> 00:29:51,720 Speaker 1: Uh probably they okated with the parents. They took the 545 00:29:51,720 --> 00:29:54,760 Speaker 1: poop of forty three infants and they used it in 546 00:29:54,760 --> 00:29:57,280 Speaker 1: the production of something called fhuet. I think I'm saying 547 00:29:57,320 --> 00:30:04,280 Speaker 1: that right sauce. Yeah, and uh no. It is important 548 00:30:04,320 --> 00:30:06,800 Speaker 1: to note that there was no actual poop in this sausage. 549 00:30:07,040 --> 00:30:10,160 Speaker 1: We may say poop sausage, but the only bacteria cultured 550 00:30:10,160 --> 00:30:13,440 Speaker 1: from the poop was used to create the poop sausage. 551 00:30:13,560 --> 00:30:16,440 Speaker 1: And yet there's the association, right right, But you know, 552 00:30:16,560 --> 00:30:19,440 Speaker 1: baby poop is kind of its own holy thing. I 553 00:30:19,440 --> 00:30:21,360 Speaker 1: feel like we're a lot better about that. You have 554 00:30:21,480 --> 00:30:24,960 Speaker 1: the baby showers where people actually engage in the game. 555 00:30:25,080 --> 00:30:27,040 Speaker 1: Still where they have the candy bar in the diaper. 556 00:30:27,160 --> 00:30:31,760 Speaker 1: I've heard about this, actually seen it, but it exists supposedly, 557 00:30:31,800 --> 00:30:33,720 Speaker 1: So I feel like that's a sign that people are 558 00:30:34,200 --> 00:30:37,400 Speaker 1: they're more okay with eating consuming baby poop or something 559 00:30:37,480 --> 00:30:39,760 Speaker 1: made with baby poop than they are with this run 560 00:30:39,760 --> 00:30:43,240 Speaker 1: of the mill adult human poop. No, especially if you 561 00:30:43,320 --> 00:30:49,320 Speaker 1: consider that you know, newborn mostly is subsisting on mother's milk. Right, 562 00:30:49,400 --> 00:30:51,560 Speaker 1: So there's not a lot of crazy. I mean, presumably 563 00:30:51,600 --> 00:30:54,400 Speaker 1: there's no like Kraft macaroni and cheese in there. Right. 564 00:30:54,440 --> 00:30:57,920 Speaker 1: They are wholly blameless creatures, and the same can be 565 00:30:57,960 --> 00:31:01,040 Speaker 1: said of the the bacteria live in their excrement. There's 566 00:31:01,120 --> 00:31:05,160 Speaker 1: purity and innocence in their poop, is what we're saying. Yeah, alright, 567 00:31:05,200 --> 00:31:09,440 Speaker 1: So there you have it, fecal transplantation, poop, sausage. Anything 568 00:31:09,480 --> 00:31:12,640 Speaker 1: you could want out of a podcast, we just pumped 569 00:31:12,640 --> 00:31:14,640 Speaker 1: it into you. But do you want more, Well, head 570 00:31:14,640 --> 00:31:16,560 Speaker 1: on over to stuff to Blow your Mind dot com. 571 00:31:16,600 --> 00:31:19,480 Speaker 1: If you were streaming this episode off of Stuff to 572 00:31:19,480 --> 00:31:22,080 Speaker 1: Blow your Mind dot com, Uh, do check out the 573 00:31:22,920 --> 00:31:26,200 Speaker 1: landing page. In addition to you know, artwork, we always 574 00:31:26,200 --> 00:31:29,440 Speaker 1: make sure that we have links to related content, So 575 00:31:29,480 --> 00:31:33,200 Speaker 1: I'll include links to that microbiome article that we sourced 576 00:31:33,240 --> 00:31:35,800 Speaker 1: as well as our podcast episode, uh and any other 577 00:31:35,960 --> 00:31:38,480 Speaker 1: related We've done a number of episodes that deal with 578 00:31:38,600 --> 00:31:42,120 Speaker 1: human waste and uh and digestion. We did a whole 579 00:31:42,120 --> 00:31:45,120 Speaker 1: series on how food travels from one end of our 580 00:31:45,120 --> 00:31:47,880 Speaker 1: body to the other end. So check those out. Yeah, 581 00:31:47,880 --> 00:31:50,520 Speaker 1: there's the pooping duck episode two. I don't want to 582 00:31:50,520 --> 00:31:57,040 Speaker 1: spoil that. Oh the colt uh? All right, Um, maybe 583 00:31:57,040 --> 00:31:59,160 Speaker 1: you guys have some thoughts on f m T s. 584 00:31:59,320 --> 00:32:02,760 Speaker 1: My question to you is, would you undergo an fm 585 00:32:02,800 --> 00:32:06,000 Speaker 1: T if you found out it was like the beneficial 586 00:32:06,160 --> 00:32:09,920 Speaker 1: sort of vitamin D. Although some people are on the 587 00:32:09,920 --> 00:32:12,120 Speaker 1: fence about vitamin D, but it was like super beneficial 588 00:32:12,160 --> 00:32:14,880 Speaker 1: to you. Yeah. Not just a life threatening situation where hey, 589 00:32:14,880 --> 00:32:17,240 Speaker 1: this is your only way out of it. This is reinfection. 590 00:32:17,360 --> 00:32:20,440 Speaker 1: We treat it, but just in terms of a near 591 00:32:20,520 --> 00:32:24,040 Speaker 1: future situation where someone says, hey, you're feeling a bit blue, 592 00:32:25,080 --> 00:32:30,000 Speaker 1: how about a little brown? How about it? Yeah? Alright, 593 00:32:30,200 --> 00:32:32,200 Speaker 1: Like I'm telling you, you can really do this. I 594 00:32:32,400 --> 00:32:34,960 Speaker 1: am keeping all right, send us your thoughts and you 595 00:32:35,000 --> 00:32:37,680 Speaker 1: can do that by emailing us at Below the Mind. 596 00:32:37,760 --> 00:32:44,440 Speaker 1: It has to work dot com for more on this 597 00:32:44,640 --> 00:32:47,160 Speaker 1: and thousands of other topics. Does it have stuff works 598 00:32:47,160 --> 00:32:51,360 Speaker 1: dot com