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Speaker 1: Now here's a highlight from Coast to Coast AM on iHeartRadio.

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Speaker 2: And welcome back George nor you along with Douglas smallhall

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Speaker 2: as who are talking about your health as Lady's book

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Speaker 2: is called Discovering the Nature of Longevity. Doug tell us

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Speaker 2: a little bit about that book again. I know you're

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Speaker 2: on with me a couple of years ago when we

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Speaker 2: had you on talking about that but refreshing.

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Speaker 3: Yeah, well, George, and you know it's been the number

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Speaker 3: one Amazon bestseller several times since then. But basically, you know,

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Speaker 3: the subtitle speaks about the book and this relationship to

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Speaker 3: total stress load. It's restoring the heart and body by

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Speaker 3: targeting hidden stress. And there are many things that are

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Speaker 3: actually covered in the book that are pretty unique because

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Speaker 3: it looks at some of the hidden stresses that often

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Speaker 3: don't show off in tests, like I spoke about just

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Speaker 3: before the break, and it looks at some of the

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Speaker 3: systems in the body that most people almost are never

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Speaker 3: told about. And I'll almost no doctors are treating right now.

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Speaker 3: Just one of the most important examples is the fiber

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Speaker 3: that drives every move you make and every breath you take.

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Speaker 3: That's the elastic fiber that's in your skin, your arteries,

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Speaker 3: all of your connective tissue, all of your organs. And

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Speaker 3: you know, for anyone who wants to know what this

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Speaker 3: stuff is all about you, you can do the pinch test.

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Speaker 3: And what you can do is you can take the

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Speaker 3: skin on the back of your hand, pinch it between

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Speaker 3: your thumb and your forefinger, hold it up for about

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Speaker 3: two or three seconds, and let it go. Now, if

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Speaker 3: you're younger, it'll snap right back, but if you're older,

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Speaker 3: it goes down more slowly, and if you're really old,

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Speaker 3: it doesn't go down at all. So that's the elastic

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Speaker 3: fiber in your body, and that's actually what drives every

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Speaker 3: single movement, what lets your body breathe and pump blood

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Speaker 3: is incredibly important and most people have never heard of it. Now,

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Speaker 3: there's a nasty side story to elastin George. After the

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Speaker 3: age of thirty, it starts to do grade because the

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Speaker 3: body stops assembling it and at that point, guess what,

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Speaker 3: it gets damaged by all kinds of total stress load,

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Speaker 3: including bad food, toxins, emotional overstressed, physical injury, and even

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Speaker 3: the friction of red blood cells bumping against the walls

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Speaker 3: of your argeries. As your body pumps blood. So the

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Speaker 3: problem there is that that provokes the constant inflammation, this

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Speaker 3: chronic inflammation that actually some of the ads we're talking

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Speaker 3: about during your break, and this constant inflammation is really

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Speaker 3: bad for you and triggers a lot of these diseases.

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Speaker 3: So the good news is that there are some new

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Speaker 3: therapies out there, some of them are in clinical trial,

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Speaker 3: one of them is on the market today already that

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Speaker 3: are actually restoring this elastin fiber. And they didn't just

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Speaker 3: come out of the blue, George. They came out of

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Speaker 3: twenty five years of hard research that led to several

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Speaker 3: discoveries in how to restore elastin fiber. And I'm the

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Speaker 3: co founder of a company called Elastrin Therapeutics, which is

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Speaker 3: actually focusing on restoring the elastic fiber and arteries and

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Speaker 3: reversing this calcification that I spoke about earlier where we're

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Speaker 3: all attorney to stone because degraded elastic and calcification are

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Speaker 3: closely linked. So that's the other focus of the book

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Speaker 3: is on these new technologies and therapies that are actually

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Speaker 3: repairing the damage done by this total stress load. So

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Speaker 3: the other thing is that the book also describes a

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Speaker 3: few well established nutraceutical therapies that are restoring vascular health,

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Speaker 3: and foremost among those is something called NANOBACTX. It's been

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Speaker 3: around for twenty five years and it seems to have

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Speaker 3: a pretty good track record. You can see more about

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Speaker 3: NANOBACTX on the book's website, and I've also written a

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Speaker 3: companion publication about this, called The Story of Nanobactx, which

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Speaker 3: is on Amazon. So the problem faced by all of

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Speaker 3: those solutions, George, is that it's ridiculously expensive to get

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Speaker 3: approved as a therapy because you have to do clinical

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Speaker 3: trials costing tens of millions or hundreds of millions of dollars.

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Speaker 3: So a lot of good solutions out there simply don't

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Speaker 3: have the financial firepower to go through that process and

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Speaker 3: aren't recognized in conventional billing reimbursement systems. Now that's beginning

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Speaker 3: to change, but it's slow. So all of those factors

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Speaker 3: are covered in quite some detail in the book.

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Speaker 2: Is a little bit of stress good for you, Douglass

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Speaker 2: at all?

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Speaker 1: Bad?

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Speaker 3: Oh, George, You hit the nail on the head. Absolutely,

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Speaker 3: some stress is essential for good health. But he needs

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Speaker 3: some physical stress to keep in shape. Your brain needs

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Speaker 3: to be pushed to keep you alert and constantly learning.

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Speaker 3: In emergencies, a short burst of stress gets your adrenaline flowing,

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Speaker 3: keeps you really sharp, and can get you out of trouble.

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Speaker 3: Your emotions can also be from a bit of stress,

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Speaker 3: so you can learn how to deal with difficult situations.

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Speaker 3: So actually there's a lot of short term stresses that

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Speaker 3: are basically keeping us alive. Now, telling when it becomes

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Speaker 3: bad for you can be tricky business, because anyone who's

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Speaker 3: been overstressed for a long period knows that sometimes you

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Speaker 3: just don't notice until it's too late you get sick.

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Speaker 3: But there are all the normal warning signs like constant fatigue, irritability,

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Speaker 3: feeling run down, not sleeping well, and these can be

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Speaker 3: a result and a cause. But in a nutshell, George, yes,

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Speaker 3: stress is essential for our lives, but that's short term stress.

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Speaker 3: That's a different beast.

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Speaker 1: That is amazing.

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Speaker 2: What does some doctors say about this, Douglas, Well, that's

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Speaker 2: very interesting.

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Speaker 3: You should mention that, George, because the healthcare system is

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Speaker 3: starting to change its attitude towards this, because it's being

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Speaker 3: overwhelmed by chronic conditions that are not responding well to

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Speaker 3: conventional approaches. Now, the good news is that there's a

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Speaker 3: new generation of doctors coming up who are much more

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Speaker 3: aware of these integrated factors. And there's a well established

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Speaker 3: cadre of thousands of holistic and integrative physicians out there

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Speaker 3: who are well aware of total stressload. The other thing, George,

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Speaker 3: is that total stressload is far more measurable than it

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Speaker 3: used to be. And that's because there's a wider range

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Speaker 3: of instruments and biomarkers. And I just want to give

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Speaker 3: you a few examples so people that there can see

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Speaker 3: what I'm talking about. Okay, So for example, there's some

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Speaker 3: technical names here, but there's something called Life Events and

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Speaker 3: Difficulties Scheduling or LEADS, and this is a structured interview

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Speaker 3: that assesses the major stressors across your lifetime. It's scored

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Speaker 3: on severity and the duration of stress. The Stress and

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Speaker 3: Adversity Inventory, the acronym HAHA is strained. It's a computer

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Speaker 3: assistant questionnaire that adds up lifetime and recent stressors acute

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Speaker 3: and chronic, and that produces a cumulative stress score. There's

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Speaker 3: the Homes and Ray Stress Scale, and this is a

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Speaker 3: checklist that assigns life change units to major life events,

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Speaker 3: and then scores reflect the total stress load and are

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Speaker 3: correlated with the risk of illness. There's a whole bunch

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Speaker 3: of others perceive stress stress scale physiological biomarkers of alostatic

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Speaker 3: load George. Now, allostatic load is the medical term for

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Speaker 3: total stress load, and it was actually developed in the

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Speaker 3: early nineteen nineties by scientists who actually did the science

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Speaker 3: and were able to quantify that. So some of the

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Speaker 3: composite scores that you see around this include a combination

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Speaker 3: of blood pressure, waste of hip ratio, fasting, glucose serum, cortisol,

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Speaker 3: and a whole bunch of other things. So you can

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Speaker 3: see that there are a lot of these methodologies out

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Speaker 3: there that conventional medicine is really starting to pay attention

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Speaker 3: to now because they're getting desperate. The whole system is

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Speaker 3: being overstressed by people who had stressed well.

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Speaker 2: With Douglas small Hall, author of the Discovering the Nature

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Speaker 2: of Longevity, we'll take calls with Douglas next hour here

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Speaker 2: on Coast to Coast. Truly remarkable. How did you uncover this?

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Speaker 3: I didn't uncover it, George. What I did was, I

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Speaker 3: have to say I made a discovery of the work

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Speaker 3: of a scientist. His name is doctor Neuren Vivahari, and

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Speaker 3: he is the guy who actually discovered that the impacts

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Speaker 3: of this total stress load on the elastic in our

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Speaker 3: body is what was triggering cardiovascular conditions. And the way

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Speaker 3: he did it, George, was absolutely fascinating. He was trying

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Speaker 3: to understand why in heart valves, one side of the

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Speaker 3: heart valve turns to stone it calcifies, and the other

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Speaker 3: side of the heart valve wasn't calcifying. And when he

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Speaker 3: did the microscopic examination, he found that the side that

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Speaker 3: was calcifying had much higher levels of elastin fiber to

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Speaker 3: keep it flexible, and that elastin fiber, as I described earlier,

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Speaker 3: was degrading. Now as it degraded, George, what was happening

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Speaker 3: was it was sending out, hey, help me, help me

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Speaker 3: fix me signal, and the cells in the body were

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Speaker 3: responding to that with guess what inflammation to clean up

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Speaker 3: the mess so that you know, the elastin could be repaired.

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Speaker 3: The only problem is that the body wasn't repairing it

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Speaker 3: anymore because it wasn't manufacturing or assembling this elastic fiber.

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Speaker 3: So this, this is what this is a major cause

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Speaker 3: of aging, it turns out, and this is what's been

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Speaker 3: cutting into our longevity. So when doctor Vavahari expanded this

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Speaker 3: and he looked into the wall of the arteries, he

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Speaker 3: discovered that the wall of the artery has this degraded

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Speaker 3: elastin in it. And guess what that is exactly where

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Speaker 3: the calcification begins, dis hardening of the arteries. A lot

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Speaker 3: of people are told, oh, yes, you know, it's cholesterol

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Speaker 3: that causes arterial stiffening. Well it does, but most of

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Speaker 3: the time that comes along a lot later after this

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Speaker 3: damage to lastin has caused this chronic inflammation in the

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Speaker 3: wall of the artery or in the lining of the

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Speaker 3: artery that actually is where the blood flows through the arteries.

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Speaker 3: So then George he started looking, he started looking for

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Speaker 3: things that could could prevent this, and he came up

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Speaker 3: with two things. One was a well known chemical. It's

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Speaker 3: approved by the FDA. It's called DTA and it's known

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Speaker 3: to grab heavy metals out of tissue and you know,

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Speaker 3: take it out of your body. There's a process called

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Speaker 3: keelation that's been used, you know, for years and years

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Speaker 3: and years to get rid of these these these heavy

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Speaker 3: metals and when he used this is in very high amounts,

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Speaker 3: he found that it could actually decalcify this damaged elastin.

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Speaker 3: The problem, George, is that those high levels were toxic themselves.

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Speaker 3: So what he had to do was he had to

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Speaker 3: package the decalcifying stuff into nanoparticles that were targeted specifically

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Speaker 3: to this damaged elastin. And for that, he and doctor

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Speaker 3: Charles Rice together had to invent an antibody that was

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Speaker 3: specific for damaged elastin. And when they did that bingo,

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Speaker 3: they were able to deliver high concentrations of this decalcifying

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Speaker 3: material straight to the elastin without toxifying the rest of

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Speaker 3: the body. And now that therapy is going into clinical

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Speaker 3: trial testing, and actually there's one company that has used

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Speaker 3: another substance that actually restores the elastin that is in

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Speaker 3: phase three testing right now for preventing aneurysms from bursting,

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Speaker 3: because aneurysms are caused by the weakened the lastin in

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Speaker 3: your body. Yeah, it's really exciting stuff, George, And anyone

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Speaker 3: who has an aneurism, and there's ten million Americans out

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Speaker 3: there who have it, should go to the site of

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Speaker 3: Nectaro Medical. You can find it on my website because

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Speaker 3: they are still recruiting for their clinical trials on preventing

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Speaker 3: aneurysms from bursting, George, So that's becoming available in clinical

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Speaker 3: trials right now, Douglas.

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Speaker 2: Can you have too much elastin in your system?

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Speaker 3: Well, that's a good question, George, because actually too much

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Speaker 3: alastin is not the problem. Too much incompletely formed and

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Speaker 3: damaged elastin particles are what's causing the problem because guess what,

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Speaker 3: the body recognizes those as foreign objects and so it

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Speaker 3: triggers the immune system to have this chronic inflammatory response.

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Speaker 3: So these are known as elastin degradation particles or eedps,

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Speaker 3: and you will find there's a test for levels of

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Speaker 3: edps in the blood, and as we age, guess what,

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Speaker 3: the EDT levels start to accelerate, and in people with

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Speaker 3: severe heart disease, for example, they are highly elevated. So

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Speaker 3: the answer to your question is the stuff that's incompletely

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Speaker 3: formed because the body is no longer assembling it, and

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Speaker 3: the stuff that is the result of degradation is definitely

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Speaker 3: causing problems throughout the whole body. That is what you

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Speaker 3: can have too much of. But the good news is

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Speaker 3: that these new therapies are starting to solve that problem.

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Speaker 2: Excellent. Now you mentioned cholesterol earlier. I'm told that too

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Speaker 2: low of cholesterol is worse than too high.

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Speaker 3: Well, it's like everything else, ay, I mean you do

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Speaker 3: need to have a balance. I mean cholesterol is Yes,

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Speaker 3: it's essential for some of your cells to function, so

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Speaker 3: you know, it's not a nasty, that awful thing. But

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Speaker 3: here's the question, why do you get this cholesterol build

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Speaker 3: up in your arteries? That starts to make sense, George,

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Speaker 3: when you get into this injury inflammation cascade that is

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Speaker 3: a result of this damage to elasti Because here's what happens.

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Speaker 3: What happens is that when the cells detect this injury

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Speaker 3: to the elastic fiber, they respond with an inflammatory response.

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Speaker 3: That inflammatory response involves delivering certain proteins, so inflammatory proteins,

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Speaker 3: to the site of the damage to clean it up.

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Speaker 3: Those inflammatory proteins aren't just thrown out of the cell

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Speaker 3: willy nilly. They're packaged in little things called ECerS XXXI zomes,

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Speaker 3: which are little nanoparticles that are programmed with inflammatory and

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Speaker 3: guess what, calcifying nanoparticles and proteins that actually try to

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Speaker 3: wall off the problem.

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Speaker 1: Listen, to more. Coast to Coast AM every weeknight at

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