1 00:00:03,080 --> 00:00:05,960 Speaker 1: Welcome to Stuff to Blow your Mind from how Stuff 2 00:00:05,960 --> 00:00:13,280 Speaker 1: Works dot com. Hey, you welcome to Stuff to Blow 3 00:00:13,320 --> 00:00:15,880 Speaker 1: your mind. My name is Robert lamp and Julie Douglas, 4 00:00:15,920 --> 00:00:17,320 Speaker 1: and I'd like you to take a moment to just 5 00:00:17,360 --> 00:00:22,840 Speaker 1: try and create. Try and imagine the most destructive disease possible. 6 00:00:23,000 --> 00:00:27,480 Speaker 1: Imagine a disease that ravages the body. That ravage is 7 00:00:27,520 --> 00:00:30,560 Speaker 1: just about every tissue, every every part of the human 8 00:00:30,600 --> 00:00:34,640 Speaker 1: form that it takes down. The sex organs that that 9 00:00:34,760 --> 00:00:38,000 Speaker 1: takes apart the face, takes apart your identity, and in 10 00:00:38,080 --> 00:00:41,040 Speaker 1: some cases ultimately robbed you of your mind as well 11 00:00:41,200 --> 00:00:44,720 Speaker 1: before killing you outright. Yeah, you mentioned sex organs. So 12 00:00:44,840 --> 00:00:47,879 Speaker 1: also imagine that there's a moral to mention to this 13 00:00:48,120 --> 00:00:51,480 Speaker 1: disease that would give you the sort of outward appearance 14 00:00:51,520 --> 00:00:56,560 Speaker 1: that perhaps you had been engaging in conduct unbecoming to you. Yes, 15 00:00:56,840 --> 00:00:58,800 Speaker 1: And of course, in all of this, we're talking about 16 00:00:58,840 --> 00:01:02,480 Speaker 1: a very real ill this and that is syphilis. We're 17 00:01:02,480 --> 00:01:05,360 Speaker 1: actually going to devote two whole episodes to syphilis here. 18 00:01:05,560 --> 00:01:08,920 Speaker 1: This first episode, Syphilis the Great Imitator, is mainly going 19 00:01:08,959 --> 00:01:13,240 Speaker 1: to focus on the organism that causes syphilis and how 20 00:01:13,360 --> 00:01:17,200 Speaker 1: syphilis manifests itself in the human body. In the second episode, 21 00:01:17,400 --> 00:01:21,080 Speaker 1: we are going to get into the cultural and historical 22 00:01:21,160 --> 00:01:23,880 Speaker 1: impact of syphilis, because that that in its own right 23 00:01:23,959 --> 00:01:27,360 Speaker 1: is an enormous topic of interest, because for four and 24 00:01:27,400 --> 00:01:32,920 Speaker 1: a half centuries, syphilis ravages the Old World, ravages Western culture, 25 00:01:33,240 --> 00:01:37,600 Speaker 1: and it's it's really kind of difficult to overstate the 26 00:01:37,600 --> 00:01:42,200 Speaker 1: the role that syphilis played in coloring Western civilization during 27 00:01:42,200 --> 00:01:44,720 Speaker 1: that time. Yes, don't run away, because this is alf 28 00:01:44,760 --> 00:01:47,800 Speaker 1: really interesting that the bacterium itself is fascinating, and then 29 00:01:47,840 --> 00:01:51,440 Speaker 1: of course the cultural implications. Now we have our first 30 00:01:51,480 --> 00:01:57,080 Speaker 1: recorded epidemic of venereal syphilis occurring in Europe, and by 31 00:01:57,120 --> 00:02:00,200 Speaker 1: the close of the fifteenth century you have chaos just 32 00:02:00,400 --> 00:02:05,240 Speaker 1: raining in Naples, Italy, where there's a huge outbreak. In fact, uh, 33 00:02:05,480 --> 00:02:09,920 Speaker 1: Pope Innocent the eighth asked French King Charles the Eighth 34 00:02:10,120 --> 00:02:12,200 Speaker 1: to invade the city with troops to try to keep 35 00:02:12,200 --> 00:02:14,600 Speaker 1: it under control. But what do you think happens? Well, 36 00:02:15,440 --> 00:02:18,160 Speaker 1: as we would as we it would eventually learned, Sending 37 00:02:18,160 --> 00:02:21,040 Speaker 1: troops then to deal with syphilis not the best strategy 38 00:02:21,520 --> 00:02:24,240 Speaker 1: because because that they're going to end up catching the syphilis. 39 00:02:24,320 --> 00:02:26,000 Speaker 1: And then when you draw the troops out, they're going 40 00:02:26,040 --> 00:02:29,920 Speaker 1: to take the syphilis elsewhere exactly. And the problem here 41 00:02:30,000 --> 00:02:33,280 Speaker 1: is that syphlis has being known as the great imitator 42 00:02:33,480 --> 00:02:36,800 Speaker 1: because it has all these different symptoms that at the 43 00:02:36,919 --> 00:02:41,639 Speaker 1: outset might be mistaken for other illnesses. So imagine this 44 00:02:41,680 --> 00:02:43,800 Speaker 1: time period in which this was happening and people not 45 00:02:43,919 --> 00:02:47,320 Speaker 1: quite knowing what they were dealing with. Yeah, to quote 46 00:02:47,520 --> 00:02:49,880 Speaker 1: Sir William Afler, he says, no syphilis in all its 47 00:02:49,960 --> 00:02:52,960 Speaker 1: manifestations and relations and all other things clinical will be 48 00:02:53,000 --> 00:02:55,160 Speaker 1: added to you. There is no organ in the body, 49 00:02:55,200 --> 00:02:58,520 Speaker 1: nor any tissue in the organs, which syphilis does not invade. 50 00:02:58,800 --> 00:03:02,480 Speaker 1: And it is therefore manifestly difficult to speak, at least 51 00:03:02,680 --> 00:03:05,639 Speaker 1: at all concisely of the pathology of the disease, just 52 00:03:05,720 --> 00:03:08,680 Speaker 1: as as it is almost impossible to describe its clinical 53 00:03:08,720 --> 00:03:12,840 Speaker 1: symptoms without mentioning almost every symptom of every known disease. 54 00:03:13,320 --> 00:03:15,280 Speaker 1: And these symptoms are not going to be the same 55 00:03:15,320 --> 00:03:17,520 Speaker 1: from one person to the next. So you have a 56 00:03:17,560 --> 00:03:21,119 Speaker 1: disease that is that is seemingly very stealthy, very nefarious. 57 00:03:21,200 --> 00:03:24,560 Speaker 1: It's uh, it's it's changing its shape, it's changing its strategy, 58 00:03:24,600 --> 00:03:27,720 Speaker 1: it's going dormant it's popping back up and uh and 59 00:03:27,800 --> 00:03:30,320 Speaker 1: the whole time everyone's trying to understand what's going on, 60 00:03:30,400 --> 00:03:33,240 Speaker 1: how to prevent it. Uh. Again, there there's there's this 61 00:03:33,400 --> 00:03:36,440 Speaker 1: this whole seemingly moral side to it because it's spread 62 00:03:36,680 --> 00:03:40,560 Speaker 1: through sexual contact, and it ends up spreading across every 63 00:03:40,680 --> 00:03:44,360 Speaker 1: social level in society. Uh. It's it's a disease that 64 00:03:44,480 --> 00:03:48,200 Speaker 1: ravages the poor, it ravages the rich. It's hitting the royalty, 65 00:03:48,280 --> 00:03:51,400 Speaker 1: it's hitting the clergy, it's hitting anyone who's engaging in 66 00:03:51,440 --> 00:03:54,920 Speaker 1: sexual contact, which is everyone, right, And in fact, it 67 00:03:55,000 --> 00:03:58,680 Speaker 1: is so prevalent that you get a couple of references 68 00:03:58,720 --> 00:04:01,360 Speaker 1: to it in Shakespeare's works like pox of your houses 69 00:04:01,400 --> 00:04:03,760 Speaker 1: and Romeo a nguliet, which is now a curse like 70 00:04:03,840 --> 00:04:07,640 Speaker 1: a pox on you. It's but the problem with this is 71 00:04:07,600 --> 00:04:09,400 Speaker 1: is that we tend to think of it as this 72 00:04:09,560 --> 00:04:14,880 Speaker 1: antiquated illness, right, it is not. In fact, The Centers 73 00:04:14,920 --> 00:04:19,320 Speaker 1: for Disease Control estimate that annually more than fifty five 74 00:04:19,680 --> 00:04:24,159 Speaker 1: people in the US get new syphilis infections, and during 75 00:04:24,160 --> 00:04:26,680 Speaker 1: two thousand and twelve there were more than forty nine 76 00:04:26,680 --> 00:04:31,719 Speaker 1: thousand reported new cases of syphilis, compared to forty thousand 77 00:04:31,920 --> 00:04:36,839 Speaker 1: estimated new diagnosis of HIV. So it is still present 78 00:04:37,440 --> 00:04:40,400 Speaker 1: and it is most common in people between the ages 79 00:04:40,480 --> 00:04:44,040 Speaker 1: of twenty and twenty nine years of age, which has 80 00:04:44,160 --> 00:04:47,960 Speaker 1: led it to be called Cupid's disease by the way. Yeah, 81 00:04:48,120 --> 00:04:50,400 Speaker 1: and of course, one other way we should mention that 82 00:04:50,440 --> 00:04:53,720 Speaker 1: you can transfer syphilis is through an unborn child, and 83 00:04:53,800 --> 00:04:57,159 Speaker 1: so congenital syphilis, which will we'll talk about a little 84 00:04:57,160 --> 00:05:00,320 Speaker 1: bit more later. That's also a huge problem because when 85 00:05:00,320 --> 00:05:04,640 Speaker 1: the syphilis manifests in a newborn child, uh, the the 86 00:05:04,640 --> 00:05:07,839 Speaker 1: the effects are kind it can be pretty disastrous. So 87 00:05:07,880 --> 00:05:10,320 Speaker 1: once against syphilis, even though it is a tremendous interest 88 00:05:10,360 --> 00:05:14,880 Speaker 1: from a historical standpoint, it is not a purely historical disease. 89 00:05:15,120 --> 00:05:18,760 Speaker 1: Now we just don't put as much emphasis on it 90 00:05:18,839 --> 00:05:23,520 Speaker 1: these days in terms of infectious diseases because it can 91 00:05:23,520 --> 00:05:26,280 Speaker 1: be controlled by penicillin, and we'll talk about that later. Yes, yes, 92 00:05:26,279 --> 00:05:29,280 Speaker 1: they can be wiped out by penicillin and uh uh. 93 00:05:29,320 --> 00:05:32,040 Speaker 1: And and that has been a huge advantage in the 94 00:05:32,040 --> 00:05:34,760 Speaker 1: war against cephalis for sure, But still it is it 95 00:05:34,839 --> 00:05:38,039 Speaker 1: is an adversary that that carries on even in the 96 00:05:38,120 --> 00:05:40,839 Speaker 1: advent of what would seem a magic bullet. Yeah, and 97 00:05:40,920 --> 00:05:46,680 Speaker 1: let's talk about this dastardly organism also known as Treponema palladum. Yes, 98 00:05:46,760 --> 00:05:50,480 Speaker 1: such Treponema palladum, which is a treponemal disease. There are 99 00:05:50,560 --> 00:05:54,000 Speaker 1: other treponemal diseases which will get into these and co 100 00:05:54,200 --> 00:05:58,000 Speaker 1: include a visual penta and yaws. None of these, of 101 00:05:58,040 --> 00:06:02,000 Speaker 1: course are sexually transmitted, but they are essentially skin ailments 102 00:06:02,040 --> 00:06:05,520 Speaker 1: that are that are transferred by skin to skin contact. Yes, 103 00:06:05,600 --> 00:06:08,880 Speaker 1: so they are related to Treponema palladum, but they themselves, 104 00:06:08,880 --> 00:06:13,599 Speaker 1: as you say, are not spread through sexual contact. And 105 00:06:13,640 --> 00:06:15,760 Speaker 1: I should add to to be clear if you want 106 00:06:15,760 --> 00:06:20,800 Speaker 1: to get really particular. Syphilis is caused by a subspecies 107 00:06:20,880 --> 00:06:25,280 Speaker 1: of Treponema palladum, essentially Treponema paladum palatum. But for all 108 00:06:25,320 --> 00:06:30,040 Speaker 1: intents and references going forward, Treponema palladum ke palatum syphilis. 109 00:06:30,520 --> 00:06:33,159 Speaker 1: You'll know what we're talking about. Yeah, Now, this is 110 00:06:33,160 --> 00:06:35,800 Speaker 1: a spial shaped bacterium also known as a sparrow keet 111 00:06:36,279 --> 00:06:40,640 Speaker 1: and that we're talking about slender, spirally undulating bacteria here 112 00:06:41,160 --> 00:06:45,760 Speaker 1: and again. It is most often spread by sexual contact, 113 00:06:45,880 --> 00:06:50,560 Speaker 1: and the disease occurs in three primary stages. We'll talk 114 00:06:50,600 --> 00:06:55,000 Speaker 1: more about that. And uh, now, these these later stages 115 00:06:55,279 --> 00:07:00,960 Speaker 1: that will discuss are not so common in our modern era, right, yeah, 116 00:07:01,120 --> 00:07:03,960 Speaker 1: because the later stages obviously deal with a case of 117 00:07:04,000 --> 00:07:06,400 Speaker 1: syphilis that has not been treated, not been cured with 118 00:07:06,480 --> 00:07:10,080 Speaker 1: the penicillin. All right, Well, let's let's start with transmission. 119 00:07:10,080 --> 00:07:12,920 Speaker 1: And I'd like to sort of encourage you to think 120 00:07:13,160 --> 00:07:16,680 Speaker 1: throughout this with an invasion. Sorry, all right, well, let's 121 00:07:16,800 --> 00:07:20,080 Speaker 1: let's talk about how syphilis is transmitted. And I'd like 122 00:07:20,160 --> 00:07:24,320 Speaker 1: you to think about this, uh in terms of an invasion, 123 00:07:24,400 --> 00:07:26,680 Speaker 1: because that's what it is. And we're dealing with an 124 00:07:26,680 --> 00:07:29,960 Speaker 1: invasion of these spiral keets into the human body. And 125 00:07:30,000 --> 00:07:33,120 Speaker 1: this invasion takes place in a few different phases. So 126 00:07:33,200 --> 00:07:36,680 Speaker 1: syphilis can be spread again by through the through the birthless, 127 00:07:36,680 --> 00:07:41,320 Speaker 1: sent by kissing, close contact, um, transfusion of fresh human blood. 128 00:07:41,560 --> 00:07:43,560 Speaker 1: But the main ways that it's that it's spreading us 129 00:07:43,600 --> 00:07:47,520 Speaker 1: through sexual contact. We're talking vaginal sex, oral sex, anal 130 00:07:47,600 --> 00:07:51,080 Speaker 1: sex um. All of these will serve as as a 131 00:07:51,080 --> 00:07:54,239 Speaker 1: as an entry point. Now, the way that the spiro 132 00:07:54,320 --> 00:07:57,560 Speaker 1: keets into the body they enter through the skin, and 133 00:07:57,600 --> 00:08:00,440 Speaker 1: when intimate contact of this nature is made that is 134 00:08:00,440 --> 00:08:02,720 Speaker 1: when when the spire key enters the body, enters through 135 00:08:02,720 --> 00:08:05,800 Speaker 1: the skin and there it will hang out until it 136 00:08:05,880 --> 00:08:09,520 Speaker 1: makes itself known in the form of a syphilitic sore, 137 00:08:09,600 --> 00:08:14,440 Speaker 1: also known as a shanker. And shankers occur mainly on 138 00:08:14,720 --> 00:08:18,640 Speaker 1: external genitals that jina anus or in the rectum. They 139 00:08:18,680 --> 00:08:21,280 Speaker 1: can also occur on the lips and in the mouth. 140 00:08:21,960 --> 00:08:25,040 Speaker 1: So this is when you see most of the transmission 141 00:08:25,080 --> 00:08:28,280 Speaker 1: occur among people when these sores are present. Right, this 142 00:08:28,360 --> 00:08:32,160 Speaker 1: is primary syphilis. This is first stage syphilis. And think 143 00:08:32,200 --> 00:08:35,320 Speaker 1: of this in terms of the enemy initially getting into 144 00:08:35,320 --> 00:08:38,680 Speaker 1: the fortress. This is the shanker is literally the entry 145 00:08:38,720 --> 00:08:42,439 Speaker 1: point for the for the spiro keets. And it may 146 00:08:42,440 --> 00:08:44,079 Speaker 1: be a small number of spire keets and maybe a 147 00:08:44,160 --> 00:08:46,160 Speaker 1: larger number of spire keets, but this is where they're 148 00:08:46,200 --> 00:08:48,880 Speaker 1: getting in. This is the whole in the fortress wall. Yeah. 149 00:08:48,880 --> 00:08:52,160 Speaker 1: And these shankers can appear usually around twenty one days 150 00:08:52,200 --> 00:08:55,720 Speaker 1: after infection, but sometimes as little as ten or even 151 00:08:55,840 --> 00:08:58,640 Speaker 1: ninety days. Yeah, and it may hang around for three 152 00:08:58,640 --> 00:09:01,480 Speaker 1: to six weeks. And here's the thing. They can if 153 00:09:01,480 --> 00:09:05,280 Speaker 1: you look up pictures online and sure, you should definitely 154 00:09:05,280 --> 00:09:07,839 Speaker 1: go into a Google image search for for what these 155 00:09:07,880 --> 00:09:11,800 Speaker 1: look like? Your loins, your your loins, but they may 156 00:09:11,840 --> 00:09:15,559 Speaker 1: look pretty intense at times, but these are painless, uh, 157 00:09:15,600 --> 00:09:19,360 Speaker 1: And they're easily confused with any number of small skin 158 00:09:19,440 --> 00:09:23,080 Speaker 1: ailments that may pop up in even a healthy person's life, 159 00:09:23,080 --> 00:09:26,480 Speaker 1: you know, the stuff like ingrown hairs or or you know, 160 00:09:26,880 --> 00:09:29,600 Speaker 1: or various other bumps. So then would be caused by 161 00:09:29,640 --> 00:09:32,880 Speaker 1: by any number of other ailments. Again, it's a great 162 00:09:33,120 --> 00:09:36,600 Speaker 1: imitator right now. If you do not get treated at 163 00:09:36,600 --> 00:09:40,319 Speaker 1: this point, well then it gets into secondary syphilis. And 164 00:09:40,440 --> 00:09:43,400 Speaker 1: during this stage that's when you see those skin rashes, 165 00:09:43,600 --> 00:09:46,560 Speaker 1: swords in your mouth. And so that's the primary stage 166 00:09:47,160 --> 00:09:48,840 Speaker 1: and the and it's key to note here that the 167 00:09:48,880 --> 00:09:53,280 Speaker 1: shanker disappears advantishes. So if you were concerned about it, 168 00:09:53,400 --> 00:09:55,360 Speaker 1: if you really, I wonder what this painless, you know, 169 00:09:55,440 --> 00:09:58,600 Speaker 1: ugly spot on my genitals is, well, then it goes away. 170 00:09:58,960 --> 00:10:00,920 Speaker 1: And that's one of the day dangers that we see 171 00:10:01,679 --> 00:10:04,080 Speaker 1: over and over again with syphilis is that the the 172 00:10:04,080 --> 00:10:06,760 Speaker 1: infection seems to go away, the illness may seem to 173 00:10:06,800 --> 00:10:10,040 Speaker 1: go away, but as we're about to learn, it does not. 174 00:10:10,400 --> 00:10:14,320 Speaker 1: And again, imagine yourself in you know, the fifteenth century. 175 00:10:14,480 --> 00:10:16,640 Speaker 1: If you have this and then that disappears and think, oh, 176 00:10:16,679 --> 00:10:20,640 Speaker 1: everything is fine. I got upset over and over nothing, 177 00:10:20,320 --> 00:10:24,000 Speaker 1: and maybe you didn't even notice. It's it's entirely likely 178 00:10:24,040 --> 00:10:27,839 Speaker 1: that one wouldn't even notice that the shanker had popped up. Now, 179 00:10:28,080 --> 00:10:30,480 Speaker 1: most likely you wouldn't have been treated at that point 180 00:10:30,520 --> 00:10:32,960 Speaker 1: in time because there wasn't anything necessarily to treat you 181 00:10:32,960 --> 00:10:36,360 Speaker 1: with that was really effective. So it would then develop 182 00:10:36,440 --> 00:10:41,079 Speaker 1: into a secondary stage called secondary syphilis, in which you 183 00:10:41,120 --> 00:10:44,199 Speaker 1: would have skin rashes and or source in your mouth 184 00:10:44,240 --> 00:10:48,440 Speaker 1: vagina and anus, often called mucus membrane lesions. Yeah, and 185 00:10:48,480 --> 00:10:52,600 Speaker 1: you may also see other varying symptoms such as fever, lethargy, headaches, 186 00:10:53,320 --> 00:10:57,600 Speaker 1: general body aches, hair loss. And this is the point 187 00:10:57,600 --> 00:11:00,360 Speaker 1: of the invasion in which the enemy, the me made 188 00:11:00,360 --> 00:11:03,520 Speaker 1: it in in the primary stage and in secondary syphilis, 189 00:11:03,640 --> 00:11:06,560 Speaker 1: the enemy has spread throughout the castle, all right, and 190 00:11:06,559 --> 00:11:10,440 Speaker 1: and is making itself known throughout the invaded city, that 191 00:11:10,520 --> 00:11:13,360 Speaker 1: is the human body, right, And you are highly contagious 192 00:11:13,400 --> 00:11:15,680 Speaker 1: at this point. In fact, gentle, those sours caused by 193 00:11:15,679 --> 00:11:18,400 Speaker 1: syphilis make it a lot easier to transmit and acquire 194 00:11:18,480 --> 00:11:21,360 Speaker 1: things like HIV infection. Right, so you can get a 195 00:11:21,360 --> 00:11:24,360 Speaker 1: secondary infection at this point. In fact, there is an 196 00:11:24,440 --> 00:11:28,840 Speaker 1: estimated two to fivefold increased risk of acquiring HIV if 197 00:11:28,840 --> 00:11:32,079 Speaker 1: you're exposed to infection when syphilis is present in these 198 00:11:32,120 --> 00:11:36,320 Speaker 1: first and second stages. Now, at this point, after secondary syphilis, 199 00:11:36,320 --> 00:11:39,240 Speaker 1: and here again we see that the secondary syphilis, this 200 00:11:39,280 --> 00:11:42,960 Speaker 1: outbreak cut period, this goes away as well, which again 201 00:11:43,000 --> 00:11:45,160 Speaker 1: could lead someone to say, well, that was horrible, and 202 00:11:45,200 --> 00:11:47,559 Speaker 1: maybe they may not even realize that it was connected 203 00:11:47,720 --> 00:11:51,120 Speaker 1: to the primaries outbreak, And they might, but they can 204 00:11:51,160 --> 00:11:53,400 Speaker 1: easily imagine, well, I'm done with this now, it's it's 205 00:11:53,440 --> 00:11:56,520 Speaker 1: it's it's done. It's finished. Whatever illness was affecting me, 206 00:11:56,640 --> 00:11:59,120 Speaker 1: the pox has left me, right, Yeah, But little do 207 00:11:59,160 --> 00:12:02,560 Speaker 1: they know that this is just the latent stage of 208 00:12:02,640 --> 00:12:05,559 Speaker 1: this and it's just waiting around. It might not even 209 00:12:05,640 --> 00:12:08,480 Speaker 1: reveal itself for decades. Yeah. So imagine the enemy has 210 00:12:08,520 --> 00:12:10,800 Speaker 1: invaded the castle, They've made a lot of mischief, and 211 00:12:10,800 --> 00:12:12,960 Speaker 1: then suddenly they seem to be gone, But they're not gone. 212 00:12:13,000 --> 00:12:15,000 Speaker 1: There in the basement. They're in the basement, they're in 213 00:12:15,040 --> 00:12:18,040 Speaker 1: there in every house in the city. There. They've literally 214 00:12:18,040 --> 00:12:21,200 Speaker 1: become a part of the city. They're essentially a sleeper cell. Uh, 215 00:12:21,240 --> 00:12:26,200 Speaker 1: and that is what latent syphilis is. Tertiary syphilis, the 216 00:12:26,280 --> 00:12:29,600 Speaker 1: stage really is quite gruesome because it kind of takes 217 00:12:29,720 --> 00:12:32,400 Speaker 1: everything in the body down to the studs are more so, 218 00:12:32,520 --> 00:12:35,880 Speaker 1: I should say, it's like you say, the sleeper cells 219 00:12:35,920 --> 00:12:39,640 Speaker 1: in the basements. They become stronger and they come roaring 220 00:12:39,720 --> 00:12:42,959 Speaker 1: back into the body and they cause a lot of havoc. Yeah, 221 00:12:43,120 --> 00:12:45,280 Speaker 1: it's I mean, we see this over and over again 222 00:12:45,320 --> 00:12:48,920 Speaker 1: with with syphilis, but it has such metaphorical power. Is 223 00:12:48,920 --> 00:12:51,760 Speaker 1: one of the reasons that I think we're aside from 224 00:12:51,800 --> 00:12:55,040 Speaker 1: its uh, its power to harm and his figuous uh, 225 00:12:55,600 --> 00:12:58,160 Speaker 1: the reason we're drawn to it so is you do 226 00:12:58,240 --> 00:13:01,880 Speaker 1: see this idea of the the infection. It flared up, 227 00:13:01,880 --> 00:13:04,160 Speaker 1: and it flared up again, and then it comes back 228 00:13:04,600 --> 00:13:09,040 Speaker 1: in only fift The case is a much stronger form 229 00:13:09,080 --> 00:13:13,360 Speaker 1: in the tertiary stage, far more debilitating, far more destructive 230 00:13:13,640 --> 00:13:17,960 Speaker 1: and ultimately lethal stage of the illness. Yeah. In this 231 00:13:18,080 --> 00:13:21,960 Speaker 1: late stage you could have sometimes that include difficulty coordinating 232 00:13:21,960 --> 00:13:25,240 Speaker 1: your muscle movements, paralysis, not being able to move some 233 00:13:25,320 --> 00:13:29,640 Speaker 1: of your body, uh, numbness, blindness, and dementia. And then 234 00:13:29,640 --> 00:13:33,600 Speaker 1: in the late late stages, the disease begins to ravage 235 00:13:33,600 --> 00:13:37,360 Speaker 1: your internal organs, and that is what can result in death. 236 00:13:37,559 --> 00:13:39,760 Speaker 1: And this is one of the remarkable things about this 237 00:13:39,840 --> 00:13:43,079 Speaker 1: is that this stage can occur ten to twenty years 238 00:13:43,120 --> 00:13:47,959 Speaker 1: after primary syphilis. So this is it's again the metaphoralthorical 239 00:13:48,040 --> 00:13:50,400 Speaker 1: power of this. It's like the the sins of the 240 00:13:50,480 --> 00:13:55,040 Speaker 1: young individual coming back to destroy the older individual. You know. 241 00:13:55,640 --> 00:14:00,400 Speaker 1: It's um, it's it's gruesome stuff, and and and and 242 00:14:00,480 --> 00:14:03,320 Speaker 1: against that one may not even remember that first outbreak 243 00:14:03,400 --> 00:14:06,679 Speaker 1: all that clearly, and suddenly all these changes are happening 244 00:14:06,720 --> 00:14:09,320 Speaker 1: to their body and ultimately to their mind. Yeah, and 245 00:14:09,600 --> 00:14:12,719 Speaker 1: we have largely up until this point treated this in 246 00:14:12,760 --> 00:14:15,480 Speaker 1: a very clinical fashion and not really talked about the 247 00:14:15,520 --> 00:14:18,000 Speaker 1: sights and the sounds and the spells of what this 248 00:14:18,120 --> 00:14:20,840 Speaker 1: looks like, which you will do more in the next podcast. 249 00:14:21,080 --> 00:14:24,760 Speaker 1: But just know that at this point, um, this this 250 00:14:24,760 --> 00:14:28,440 Speaker 1: this is really adding injury to insult because you might 251 00:14:28,440 --> 00:14:31,560 Speaker 1: have lost your nose, you know, and recovered from that, 252 00:14:31,760 --> 00:14:34,040 Speaker 1: and and all of a sudden you think you're out 253 00:14:34,040 --> 00:14:37,600 Speaker 1: in the clear, and boom it comes back in in 254 00:14:37,760 --> 00:14:41,200 Speaker 1: such a corrosive manner that you find out that this 255 00:14:41,280 --> 00:14:44,200 Speaker 1: is really the death knell. Yeah, corrosive is an excellent 256 00:14:44,280 --> 00:14:47,200 Speaker 1: term to use, because you see the you see a 257 00:14:47,200 --> 00:14:49,520 Speaker 1: loss of teeth, you see the destruction of the palette 258 00:14:49,560 --> 00:14:52,520 Speaker 1: in the mouth. You see you see the the the 259 00:14:52,600 --> 00:14:55,880 Speaker 1: collapse of the nose into what is known as saddle nose, 260 00:14:56,560 --> 00:14:59,880 Speaker 1: where basically the nose collapses and around the bridge and 261 00:15:00,160 --> 00:15:03,200 Speaker 1: becomes kind of upturned and smaller looking uh, and then 262 00:15:03,240 --> 00:15:07,440 Speaker 1: may eventually um appear to rot entirely. Uh. Saddle nose 263 00:15:07,560 --> 00:15:09,840 Speaker 1: is also caused can also be caused by just damage 264 00:15:09,880 --> 00:15:12,800 Speaker 1: to the nose. You see boxers that suffer from saddle nose. 265 00:15:13,040 --> 00:15:18,920 Speaker 1: Also extreme cocaine addiction can somehow sometimes have that effect 266 00:15:18,960 --> 00:15:22,640 Speaker 1: on individuals. But Yeah, you're seeing it attack your facial features. 267 00:15:22,680 --> 00:15:26,840 Speaker 1: You're seeing it attack uh, your genitals in a very 268 00:15:26,840 --> 00:15:31,200 Speaker 1: destructive manner, and then also getting into your organs. Again. 269 00:15:31,240 --> 00:15:33,200 Speaker 1: To back to the quote that I read at the 270 00:15:33,200 --> 00:15:36,280 Speaker 1: beginning of the podcast by uh Dr William Ostler, it 271 00:15:36,760 --> 00:15:41,360 Speaker 1: it the spiral keets of syphilis attack every part of 272 00:15:41,360 --> 00:15:43,280 Speaker 1: the body like nothing is off limits. To go back 273 00:15:43,320 --> 00:15:47,000 Speaker 1: to that castle analogy from from earlier, the invader has 274 00:15:47,080 --> 00:15:49,480 Speaker 1: lived in the city for ten to twenty years and 275 00:15:49,560 --> 00:15:53,680 Speaker 1: now in potentially every household in the city has decided 276 00:15:53,760 --> 00:15:56,840 Speaker 1: to just burn everything to the ground. Right now. The 277 00:15:56,920 --> 00:16:00,520 Speaker 1: other part of this is that simple is as we 278 00:16:00,560 --> 00:16:04,320 Speaker 1: have mentioned before, can be transmitted through the placenta. So 279 00:16:04,360 --> 00:16:06,720 Speaker 1: what does this mean. It means that during that time 280 00:16:06,720 --> 00:16:09,760 Speaker 1: period from the fifteenth century to the twentieth century, there 281 00:16:09,760 --> 00:16:13,280 Speaker 1: are a lot of children born with syphilis also called 282 00:16:13,360 --> 00:16:16,640 Speaker 1: congenital syphilis. And even to this day, corner of the 283 00:16:16,640 --> 00:16:20,200 Speaker 1: World Health Organization, you have a million children born annually 284 00:16:20,560 --> 00:16:24,640 Speaker 1: with congenital syphilis. Yeah, and it's very serious stuff because 285 00:16:24,640 --> 00:16:27,920 Speaker 1: nearly half of all children infected with syphilis, whether in 286 00:16:27,960 --> 00:16:31,920 Speaker 1: the womb, guy shortly before or after birth, and sometimes 287 00:16:31,920 --> 00:16:35,600 Speaker 1: this can also result in still borns um And despite 288 00:16:35,640 --> 00:16:37,960 Speaker 1: the fact that syphilis can be cure with antbiotics if 289 00:16:38,040 --> 00:16:41,520 Speaker 1: caught early, there are arising rates among pregnant women in 290 00:16:41,520 --> 00:16:44,320 Speaker 1: the United States, and that of course has increased the 291 00:16:44,400 --> 00:16:47,200 Speaker 1: number of infants born with this. Now, some of the 292 00:16:47,240 --> 00:16:51,840 Speaker 1: complications include blindness, deafness, deformity of the face, and nervous 293 00:16:51,840 --> 00:16:55,120 Speaker 1: system problems. Now, why does syphilis hang out in the 294 00:16:55,120 --> 00:16:57,720 Speaker 1: body so long, you might be wondering, Well, Uh, it's 295 00:16:57,960 --> 00:17:01,360 Speaker 1: it maybe due in part to palladum having a slow 296 00:17:01,400 --> 00:17:04,560 Speaker 1: dividing time of thirty to thirty three hours, and it's 297 00:17:04,640 --> 00:17:07,919 Speaker 1: likely that P. Pallatum undergoes an even slower rate of 298 00:17:07,960 --> 00:17:12,320 Speaker 1: division during the latent stages of the disease. So it's 299 00:17:12,320 --> 00:17:17,000 Speaker 1: a it's it's a long living creature from a bacterial standpoint, Yes, 300 00:17:17,119 --> 00:17:22,080 Speaker 1: it's like a bacterial croc pot Yeah. Alright, um, let's 301 00:17:22,119 --> 00:17:25,000 Speaker 1: talk about the current state of treatment and infections. Oh 302 00:17:25,040 --> 00:17:28,239 Speaker 1: but I say current, I have to mention that there 303 00:17:28,280 --> 00:17:30,760 Speaker 1: are a couple of old timey ways in which they 304 00:17:30,760 --> 00:17:34,360 Speaker 1: were thought to be cures for it, one of which 305 00:17:35,080 --> 00:17:40,359 Speaker 1: is mercury. Yes, inhaling mercury vapor. In fact, there is 306 00:17:40,400 --> 00:17:43,440 Speaker 1: This was so common for hundreds of years that a 307 00:17:43,480 --> 00:17:45,960 Speaker 1: little phrase came out of that, A night with venus, 308 00:17:46,480 --> 00:17:50,200 Speaker 1: a lifetime with mercury. Yeah. So you would find yourself 309 00:17:50,560 --> 00:17:54,480 Speaker 1: going regularly for essentially skin treatments, taking these these mercury 310 00:17:54,520 --> 00:17:58,960 Speaker 1: steam bats, and and enduring the harmful effects of that 311 00:17:59,119 --> 00:18:02,679 Speaker 1: of that mercury relation on top of the ravages of syphilis. 312 00:18:03,119 --> 00:18:06,000 Speaker 1: It did kill the sparrow key, but yes, it also 313 00:18:06,080 --> 00:18:09,240 Speaker 1: poisoned the patient. Yeah. Well, there are a few different 314 00:18:09,520 --> 00:18:12,879 Speaker 1: factors involved. There because on one hand, uh, their you know, 315 00:18:12,920 --> 00:18:16,000 Speaker 1: their arguments to what effect the mercury had in killing 316 00:18:16,000 --> 00:18:18,399 Speaker 1: the sparrow keets, But then the sparrow keets are so 317 00:18:18,600 --> 00:18:22,840 Speaker 1: entrenched in the body. What can you do. Also, again, 318 00:18:22,960 --> 00:18:25,879 Speaker 1: think about that that primary and secondary stage, the flare 319 00:18:25,960 --> 00:18:28,600 Speaker 1: ups and the disappearance. You have individuals that could go 320 00:18:28,600 --> 00:18:31,240 Speaker 1: into it to be treated for for their symptoms of syphilis, 321 00:18:31,520 --> 00:18:35,120 Speaker 1: and lo and behold, the symptoms vanish with the treatment, 322 00:18:35,480 --> 00:18:37,760 Speaker 1: not because of the treatment, just because of the timing 323 00:18:37,800 --> 00:18:40,840 Speaker 1: of the treatment. And ultimately, again you're dealing with four 324 00:18:40,880 --> 00:18:42,879 Speaker 1: and a half centuries in which there is no cure 325 00:18:42,920 --> 00:18:46,159 Speaker 1: for this illness. So if someone's trying to sell you 326 00:18:46,200 --> 00:18:48,160 Speaker 1: an illness, you're going to try and buy it. That's 327 00:18:48,200 --> 00:18:50,760 Speaker 1: just how it goes. And you know, this disease is 328 00:18:50,840 --> 00:18:53,760 Speaker 1: ravaging my body. If you tell me that mercury might help, 329 00:18:53,800 --> 00:18:56,480 Speaker 1: then I'm probably going to try mercury. Sure, You're gonna 330 00:18:56,480 --> 00:19:00,000 Speaker 1: try anything at that point, including malaria, which is apparently 331 00:19:00,320 --> 00:19:03,920 Speaker 1: something that was discovered in nineteen seventeen by Julius Wagner 332 00:19:04,320 --> 00:19:09,679 Speaker 1: Jarig to help halt some of the symptoms of syphilis, 333 00:19:09,680 --> 00:19:14,440 Speaker 1: particularly neurosyphilis that advanced stage in which you get psychosis 334 00:19:14,560 --> 00:19:17,520 Speaker 1: and you get paralysis. And they found that if you 335 00:19:17,720 --> 00:19:23,280 Speaker 1: induced a malarial fever in patients, well, that could help 336 00:19:23,760 --> 00:19:26,919 Speaker 1: with the actual infection. You also saw the use of 337 00:19:27,400 --> 00:19:30,840 Speaker 1: so called ciphilization treatments. This was where you would essentially 338 00:19:30,840 --> 00:19:34,480 Speaker 1: try to inoculate the patient in the same way that 339 00:19:34,520 --> 00:19:40,280 Speaker 1: you would treat them for smallpox. Um, this didn't work, uh, 340 00:19:40,400 --> 00:19:43,520 Speaker 1: But submitting yourself to the disease right right, Yeah, trying 341 00:19:43,600 --> 00:19:48,000 Speaker 1: to to build up you know, bodily immunity doesn't work. Now, 342 00:19:48,000 --> 00:19:50,920 Speaker 1: I've I've read some mixed reports of how experiments on 343 00:19:51,080 --> 00:19:56,439 Speaker 1: rabbits uh in the modern age have potentially shown some 344 00:19:56,600 --> 00:20:00,119 Speaker 1: possibility there. But you get into a situation where it 345 00:20:00,160 --> 00:20:04,840 Speaker 1: would take so many applications of syphilis and and we're 346 00:20:04,840 --> 00:20:07,040 Speaker 1: talking about a rabbit and it hasn't been studied enough 347 00:20:07,080 --> 00:20:09,240 Speaker 1: and you would certainly could not study it in humans. 348 00:20:09,760 --> 00:20:12,200 Speaker 1: So so yeah, and then also want to study it 349 00:20:12,200 --> 00:20:14,640 Speaker 1: when we have penicillin that can wipe it out. And 350 00:20:14,760 --> 00:20:18,120 Speaker 1: sometimes it's diagnosed by testing fluid from a syphilis sore 351 00:20:18,680 --> 00:20:22,560 Speaker 1: and looking for the sparrow keet via dark field microscopy. 352 00:20:22,960 --> 00:20:24,359 Speaker 1: The name of that blood test by the way, is 353 00:20:24,359 --> 00:20:27,080 Speaker 1: the Wasserman blood test uh and it was developed in 354 00:20:27,160 --> 00:20:29,879 Speaker 1: nineteen o six just to get everything in the timeline 355 00:20:29,920 --> 00:20:33,600 Speaker 1: squared away there. So, as we had mentioned, symphilis can 356 00:20:33,640 --> 00:20:36,080 Speaker 1: be treated with antibotics, So we're talking about penicillin. We're 357 00:20:36,119 --> 00:20:40,800 Speaker 1: talking about G benzotine, doxycycline, or tetracycline, and that's for 358 00:20:40,960 --> 00:20:44,240 Speaker 1: patients who are usually allergic to penicillin. In the length 359 00:20:44,240 --> 00:20:47,600 Speaker 1: of treatment depends on the extent of the infection and 360 00:20:47,720 --> 00:20:51,040 Speaker 1: factors such as the person's overall health. So let's say 361 00:20:51,040 --> 00:20:53,320 Speaker 1: you didn't get to it right away and you kind 362 00:20:53,320 --> 00:20:56,959 Speaker 1: of get to the second or have a secondary phase 363 00:20:57,080 --> 00:21:00,480 Speaker 1: of it, you would still have to deal with any 364 00:21:00,520 --> 00:21:03,719 Speaker 1: sort of ill effects that you might have sustained at 365 00:21:03,720 --> 00:21:05,880 Speaker 1: that point. All right, So at this point you might 366 00:21:05,880 --> 00:21:10,760 Speaker 1: be wondering, what can I do two decrease my chances 367 00:21:10,840 --> 00:21:15,320 Speaker 1: of catching syphilis. Well, according to the CDC, they're basically 368 00:21:15,359 --> 00:21:17,840 Speaker 1: two things you can do because there's no there's no 369 00:21:17,920 --> 00:21:20,359 Speaker 1: vaccine for syphilis. We have a cure for syphilis. But 370 00:21:20,359 --> 00:21:23,160 Speaker 1: then again you get into the problem of detecting it, 371 00:21:23,680 --> 00:21:27,120 Speaker 1: knowing to report it, etcetera um. And then even once 372 00:21:27,160 --> 00:21:31,080 Speaker 1: you've treated syphilis. There's no undoing any damage that it's done. Um, 373 00:21:31,240 --> 00:21:33,160 Speaker 1: So number one, be a part of a long term, 374 00:21:33,240 --> 00:21:36,160 Speaker 1: mutually monogamous relationship with a partner who has been tested 375 00:21:36,200 --> 00:21:39,680 Speaker 1: and it has negative STD test results. And number two 376 00:21:40,080 --> 00:21:43,240 Speaker 1: use latex condoms the right way every time you have sex. 377 00:21:43,320 --> 00:21:47,359 Speaker 1: Condoms prevent transmission of syphilis by preventing contact with a sore. 378 00:21:47,720 --> 00:21:50,639 Speaker 1: Sometimes sores occurring areas not covered by a condom. However, 379 00:21:50,960 --> 00:21:54,200 Speaker 1: in contact with these sores can still transmit syphilis because 380 00:21:54,200 --> 00:21:58,040 Speaker 1: again it's about it. It's it come goes through the skin. 381 00:21:58,119 --> 00:22:03,639 Speaker 1: It's not something that travels through the orifice. Now this 382 00:22:03,720 --> 00:22:06,679 Speaker 1: might surprise you, but the people who really need to 383 00:22:06,760 --> 00:22:13,000 Speaker 1: hear this most besides year olds, are senior citizens. Yes, 384 00:22:13,040 --> 00:22:15,719 Speaker 1: and this surprised me. This was some some some interesting 385 00:22:15,920 --> 00:22:19,080 Speaker 1: material that you discovered. Yeah, we actually a while ago 386 00:22:19,119 --> 00:22:20,760 Speaker 1: we had someone from the CDC come and talk to 387 00:22:20,800 --> 00:22:23,879 Speaker 1: us about STDs. Not because our our group needed a 388 00:22:24,000 --> 00:22:27,480 Speaker 1: talking to because the outbreak at work right now, but 389 00:22:27,520 --> 00:22:29,720 Speaker 1: because every once in a while someone will come and 390 00:22:29,720 --> 00:22:32,480 Speaker 1: and sort of give us information and and um, it's 391 00:22:32,480 --> 00:22:37,200 Speaker 1: always very interesting. And he had mentioned then that retirement communities, 392 00:22:37,280 --> 00:22:42,879 Speaker 1: assisted living facilities these are all hotbeds for STDs, and 393 00:22:43,080 --> 00:22:46,879 Speaker 1: this is in part because they are not practicing safe sex. 394 00:22:47,320 --> 00:22:51,480 Speaker 1: And also you have to keep in mind that that 395 00:22:51,600 --> 00:22:55,800 Speaker 1: for a long time, perhaps many of of the community 396 00:22:55,840 --> 00:22:59,720 Speaker 1: members were in long term relationships, but now they probably 397 00:22:59,760 --> 00:23:05,040 Speaker 1: have lost a partner. And it's a very social community. 398 00:23:05,440 --> 00:23:08,080 Speaker 1: There's a lot of sex going on within your citizens 399 00:23:08,200 --> 00:23:12,000 Speaker 1: in these communities, and numbers from the Centers for Disease 400 00:23:12,040 --> 00:23:16,160 Speaker 1: Control and Prevention show a rapid increase among older people. 401 00:23:16,480 --> 00:23:18,879 Speaker 1: Were talking about between two thousand and seven and two 402 00:23:18,920 --> 00:23:23,080 Speaker 1: thousand and eleven, clamydia infections among Americans sixty five and 403 00:23:23,160 --> 00:23:29,720 Speaker 1: over increased by and syphilis by fifty two percent. See, 404 00:23:29,760 --> 00:23:32,119 Speaker 1: I just had I had no idea. I end up 405 00:23:32,160 --> 00:23:35,159 Speaker 1: struggling to try and piece together, like a timeline for 406 00:23:35,240 --> 00:23:40,600 Speaker 1: a hypothetical UH assisted living resident, how they acquire the 407 00:23:40,640 --> 00:23:43,080 Speaker 1: syphilis and then how and then how they end up 408 00:23:43,080 --> 00:23:46,360 Speaker 1: passing it on to multiple people in the facility. They 409 00:23:46,400 --> 00:23:48,760 Speaker 1: just need to get the old posters, you know, in 410 00:23:48,840 --> 00:23:51,000 Speaker 1: the nineteen forties and put them back up, and we'll 411 00:23:51,040 --> 00:23:53,400 Speaker 1: talk more about that in the next episode. But there 412 00:23:53,400 --> 00:23:57,159 Speaker 1: were definite campaigns, uh, you know, trying to get some 413 00:23:57,200 --> 00:24:01,719 Speaker 1: sort of awareness going with Americans about s TDS. Indeed, yes, 414 00:24:01,760 --> 00:24:04,040 Speaker 1: we'll get into all of that in our next episode 415 00:24:04,280 --> 00:24:08,480 Speaker 1: titled Syphilis through the Ages. Alright, so there you have it, UH, 416 00:24:08,640 --> 00:24:13,119 Speaker 1: A little introduction there to syphilis, to treponema palatum, to 417 00:24:13,320 --> 00:24:16,399 Speaker 1: the spiral keet, and with what it does to the 418 00:24:16,440 --> 00:24:19,520 Speaker 1: body as it invades and then sets sets up a 419 00:24:19,560 --> 00:24:23,879 Speaker 1: residence and ultimately in some cases tears the body down. 420 00:24:24,600 --> 00:24:26,800 Speaker 1: In our next episode we will get into all the 421 00:24:27,240 --> 00:24:29,560 Speaker 1: cultural aspects of this, well maybe not all of them, 422 00:24:29,560 --> 00:24:32,040 Speaker 1: but some of the high points for sure, the history 423 00:24:32,119 --> 00:24:35,479 Speaker 1: of the disease in Western culture. UM, all of that. 424 00:24:35,680 --> 00:24:39,159 Speaker 1: So do check that episode out. UM if you enjoyed 425 00:24:39,240 --> 00:24:41,840 Speaker 1: this one. UH. In the meantime, be sure to head 426 00:24:41,920 --> 00:24:44,159 Speaker 1: up stuff to Blow your Mind dot com. That is 427 00:24:44,160 --> 00:24:46,199 Speaker 1: where you will find all of our podcast episodes are 428 00:24:46,240 --> 00:24:48,720 Speaker 1: blog post our videos, links out to our various social 429 00:24:48,720 --> 00:24:51,920 Speaker 1: media accounts and UH and when you do check out 430 00:24:52,359 --> 00:24:55,720 Speaker 1: the podcast page for this episode. In the next cephilis episode, 431 00:24:56,160 --> 00:25:00,000 Speaker 1: I'll include some links to some cool resources about syphilis, 432 00:25:00,080 --> 00:25:02,040 Speaker 1: about the history of the illness, as well as links 433 00:25:02,080 --> 00:25:06,280 Speaker 1: to various blog posts that we put together that deal 434 00:25:06,359 --> 00:25:07,879 Speaker 1: with the topics. So you can see some of these 435 00:25:07,920 --> 00:25:11,720 Speaker 1: posters that we're talking about, you can see some images 436 00:25:12,040 --> 00:25:16,399 Speaker 1: of tertiary syphilis, etcetera. And after you've visit such to 437 00:25:16,440 --> 00:25:19,199 Speaker 1: blow your Mind dot com and percolate on all of this, 438 00:25:19,440 --> 00:25:21,199 Speaker 1: no doubt you'll have some thoughts that you want to 439 00:25:21,200 --> 00:25:25,000 Speaker 1: share with us, and you can do that. And also 440 00:25:25,040 --> 00:25:28,280 Speaker 1: I wanted to mention if you have personal accounts of 441 00:25:28,680 --> 00:25:31,840 Speaker 1: STDs that you want to share, be assured that we 442 00:25:31,880 --> 00:25:35,520 Speaker 1: will not share your name, that we will keep this confidential, 443 00:25:35,920 --> 00:25:38,320 Speaker 1: so you can send your missive to us about this 444 00:25:38,400 --> 00:25:41,600 Speaker 1: stuff at blow the Mind at house touff works dot 445 00:25:41,680 --> 00:25:48,960 Speaker 1: com for more on this and thousands of other topics. 446 00:25:49,080 --> 00:26:00,000 Speaker 1: Does it How stuff works dot com