1 00:00:03,120 --> 00:00:06,000 Speaker 1: Welcome to Stuff to Blow your Mind from how Stuff 2 00:00:06,000 --> 00:00:14,000 Speaker 1: Works dot com. Hey, welcome to Stuff to Blow your Mind. 3 00:00:14,040 --> 00:00:16,600 Speaker 1: My name is Robert Lamb, and I'm Julie Douglas. You know, Julie. 4 00:00:16,640 --> 00:00:19,079 Speaker 1: Science has done some good things for us. It's done 5 00:00:19,079 --> 00:00:21,239 Speaker 1: a lot of good things. I mean, it has really 6 00:00:21,600 --> 00:00:26,439 Speaker 1: forwarded humanity right and made us, in some ways the 7 00:00:26,880 --> 00:00:30,080 Speaker 1: kind of success story of the species that we are. Yeah, 8 00:00:30,120 --> 00:00:32,599 Speaker 1: it's kind of the skeleton of human culture, that the 9 00:00:32,600 --> 00:00:35,599 Speaker 1: thing upon which we grow and continue to grow. And 10 00:00:35,720 --> 00:00:37,160 Speaker 1: you know, and you can look at just about any 11 00:00:37,159 --> 00:00:41,960 Speaker 1: area right, medical science, exploration of inner and outer space, um, 12 00:00:42,080 --> 00:00:45,479 Speaker 1: increasing knowledge of the self, the brain, the connection, our 13 00:00:45,520 --> 00:00:47,960 Speaker 1: connection to the from the brain to the body. I mean, 14 00:00:48,000 --> 00:00:50,800 Speaker 1: pretty much everything we talk about every week is is 15 00:00:50,800 --> 00:00:54,040 Speaker 1: a testament to what science is doing and has done 16 00:00:54,120 --> 00:00:58,200 Speaker 1: for humans. And while the pursuit of science, what we 17 00:00:58,240 --> 00:01:01,600 Speaker 1: think about as science, has been around for a very 18 00:01:01,640 --> 00:01:04,839 Speaker 1: long time, this pursuit of knowledge and truth, the word 19 00:01:04,920 --> 00:01:09,120 Speaker 1: scientists is only one hundred and eighty years old. Before that, 20 00:01:09,160 --> 00:01:12,560 Speaker 1: a person might be called a natural philosopher. And before 21 00:01:12,560 --> 00:01:16,800 Speaker 1: that you had economists, you had philosophers, and what we 22 00:01:16,880 --> 00:01:21,360 Speaker 1: now call scientists. All co mingling under the same roof, 23 00:01:21,680 --> 00:01:25,000 Speaker 1: and this affected how science and and how we think 24 00:01:25,040 --> 00:01:28,200 Speaker 1: of it was defined and pursued. And we sort of 25 00:01:28,200 --> 00:01:31,720 Speaker 1: assumed that science and the scientific method were in place 26 00:01:31,760 --> 00:01:34,839 Speaker 1: from the get go, but in fact they hadn't really 27 00:01:34,920 --> 00:01:39,000 Speaker 1: been defined in the rules tightened, uh, you know, until 28 00:01:39,000 --> 00:01:43,120 Speaker 1: a couple of hundred years ago, because economists were pulling 29 00:01:43,160 --> 00:01:49,360 Speaker 1: for deductive reasoning, right, and scientists we're saying, no, I 30 00:01:49,400 --> 00:01:53,440 Speaker 1: think there's there's more of this inductive reasoning, which is 31 00:01:53,480 --> 00:01:56,640 Speaker 1: this premise that you you take an idea and then 32 00:01:56,680 --> 00:01:58,920 Speaker 1: you try to take it down to the studs and 33 00:01:58,960 --> 00:02:00,760 Speaker 1: prove it wrong, even theo you might want it to 34 00:02:00,760 --> 00:02:04,160 Speaker 1: be right. And the whole idea there is that you're 35 00:02:04,160 --> 00:02:06,800 Speaker 1: trying to get at this kind of truth. And this 36 00:02:06,880 --> 00:02:09,720 Speaker 1: is now something called the scientific method. But we sort 37 00:02:09,720 --> 00:02:12,520 Speaker 1: of take this for granted, this this fact that this 38 00:02:12,600 --> 00:02:16,280 Speaker 1: is only a fairly recent development in the long history 39 00:02:16,280 --> 00:02:19,480 Speaker 1: of humans. Yeah, I mean, it's it's basically how science works. 40 00:02:19,800 --> 00:02:22,400 Speaker 1: There were people who managed to make it work in 41 00:02:22,400 --> 00:02:24,600 Speaker 1: the past, but it was until recently that we actually 42 00:02:24,680 --> 00:02:26,560 Speaker 1: said this is what works, and this is why we 43 00:02:26,560 --> 00:02:31,359 Speaker 1: should stick to. Now. A lot of the advances in 44 00:02:32,360 --> 00:02:35,639 Speaker 1: century you can, you can boil down to a simple 45 00:02:35,680 --> 00:02:39,040 Speaker 1: idea trust, but very verify. And this plays into our 46 00:02:39,280 --> 00:02:44,120 Speaker 1: peer view system. Right, one scientist writes a paper, or 47 00:02:44,120 --> 00:02:46,160 Speaker 1: a team of scientists write a paper, maybe there's a 48 00:02:46,200 --> 00:02:49,160 Speaker 1: big breakthrough in it, maybe not. But then the idea 49 00:02:49,320 --> 00:02:51,800 Speaker 1: is that their peers come along, look at the paper 50 00:02:52,040 --> 00:02:56,320 Speaker 1: and try to replicate the results, just you know, tear 51 00:02:56,360 --> 00:02:59,119 Speaker 1: it apart, see what's happening in the paper and say, yes, 52 00:02:59,200 --> 00:03:01,520 Speaker 1: I agree this is working, or I have problems with 53 00:03:01,560 --> 00:03:05,200 Speaker 1: this or that, or this is complete bunk. Yeah. I mean, 54 00:03:05,200 --> 00:03:08,880 Speaker 1: it's this idea that science can police itself. And yet 55 00:03:09,440 --> 00:03:14,120 Speaker 1: we have some statistics coming out that point to other 56 00:03:14,200 --> 00:03:17,960 Speaker 1: factors going on and that perhaps we're not pursuing knowledge 57 00:03:17,960 --> 00:03:21,600 Speaker 1: for knowledge itself in some cases or truth and and 58 00:03:21,960 --> 00:03:24,680 Speaker 1: we'll discuss more of those factors in a bit. According 59 00:03:24,680 --> 00:03:27,519 Speaker 1: to the Economists article How Science Goes Wrong, in two 60 00:03:27,520 --> 00:03:31,160 Speaker 1: thousand twelve, biotech firm am Jin reported that they could 61 00:03:31,240 --> 00:03:35,920 Speaker 1: reproduce just six of fifty three landmark studies in cancer research, 62 00:03:36,560 --> 00:03:39,960 Speaker 1: and earlier Bear the drug company, managed to repeat just 63 00:03:40,040 --> 00:03:44,360 Speaker 1: a quarter of sixty seven similarly important papers. Now we're 64 00:03:44,360 --> 00:03:47,400 Speaker 1: not taking on this topic today because we think that 65 00:03:47,440 --> 00:03:49,800 Speaker 1: we are experts on this topic, but by no stretch 66 00:03:49,880 --> 00:03:52,480 Speaker 1: of imagination are we. But we do rely on a 67 00:03:52,520 --> 00:03:54,680 Speaker 1: lot of studies, and so we wanted to point this 68 00:03:54,800 --> 00:03:58,240 Speaker 1: out today to just for ourselves better understand what are 69 00:03:58,280 --> 00:04:02,760 Speaker 1: the conditions that lead to a good, solid study or experiment. 70 00:04:02,920 --> 00:04:06,400 Speaker 1: What are the conditions that lead to dubious data? Yeah, 71 00:04:06,440 --> 00:04:08,800 Speaker 1: certainly worth keeping in mind too when you find yourself 72 00:04:09,000 --> 00:04:13,320 Speaker 1: reading science journalism articles, you know, uh that asking yourself, well, 73 00:04:13,360 --> 00:04:16,320 Speaker 1: what is the study? You know, what are there problems 74 00:04:16,320 --> 00:04:18,520 Speaker 1: and it what could the problems be? Because of what 75 00:04:18,560 --> 00:04:21,880 Speaker 1: we'll discuss, there are a number of problems that can 76 00:04:21,880 --> 00:04:25,839 Speaker 1: and do occur in modern peer of viewed science. Now, 77 00:04:25,880 --> 00:04:28,720 Speaker 1: one of the things that will come up sometimes when 78 00:04:28,880 --> 00:04:32,400 Speaker 1: people write on this topic is careerism as one of 79 00:04:32,440 --> 00:04:36,479 Speaker 1: the factors that is problematic. And that's because we've all 80 00:04:36,520 --> 00:04:42,120 Speaker 1: heard the maximum published or parish right, and the spirit 81 00:04:42,240 --> 00:04:44,200 Speaker 1: of it is not so bad. I mean, the spirit 82 00:04:44,240 --> 00:04:47,400 Speaker 1: of it is really like less than a threat and 83 00:04:47,560 --> 00:04:51,680 Speaker 1: more like, hey, this is a challenge to push science forward. 84 00:04:52,200 --> 00:04:56,799 Speaker 1: Put forth your multiple lines of evidence, your hypotheses, your theories, 85 00:04:57,600 --> 00:04:59,800 Speaker 1: because we all want to share information. We wanted to 86 00:05:00,040 --> 00:05:02,480 Speaker 1: it apart, we want to try to validate it or 87 00:05:02,560 --> 00:05:06,320 Speaker 1: invalidate it, and generally create a better understanding of the 88 00:05:06,400 --> 00:05:09,720 Speaker 1: topic or the issue. So again it's an attempt at 89 00:05:09,800 --> 00:05:14,479 Speaker 1: reaching some sort of truth. And yet the reality of 90 00:05:14,600 --> 00:05:19,000 Speaker 1: published or perish now is more that it's this kind 91 00:05:19,040 --> 00:05:21,520 Speaker 1: of pressure to produce. So it's not enough for say 92 00:05:21,560 --> 00:05:25,120 Speaker 1: a faculty member at university to write a few really 93 00:05:25,160 --> 00:05:28,400 Speaker 1: good papers a year. Now they have this pressure to 94 00:05:28,440 --> 00:05:33,160 Speaker 1: write several And so there's this idea that questionable results 95 00:05:33,400 --> 00:05:37,520 Speaker 1: could come out of this, and instead of maybe making 96 00:05:37,560 --> 00:05:40,280 Speaker 1: it to a first tier journal, maybe that data goes 97 00:05:40,320 --> 00:05:44,640 Speaker 1: to a third tier journal. And yet it shouldn't necessarily 98 00:05:44,680 --> 00:05:48,839 Speaker 1: go any place. And the problem, as outlined in the 99 00:05:48,880 --> 00:05:52,799 Speaker 1: Economist article how Science Goes Wrong, is quote. In order 100 00:05:52,839 --> 00:05:57,640 Speaker 1: to safeguard their exclusivity, the leading journals impose high rejection 101 00:05:57,720 --> 00:06:02,880 Speaker 1: rates in excess of submitted manuscripts. The most striking findings 102 00:06:02,960 --> 00:06:06,240 Speaker 1: have the greatest chance of making it onto the page. 103 00:06:06,480 --> 00:06:10,000 Speaker 1: Little wonder that one in three researchers knows of a 104 00:06:10,080 --> 00:06:13,440 Speaker 1: colleague who has pepped up a paper by say, excluding 105 00:06:13,600 --> 00:06:18,159 Speaker 1: inconvenient data from results based on a gut feeling. So 106 00:06:18,279 --> 00:06:22,200 Speaker 1: we're talking about here is cherry picking information. And then 107 00:06:22,240 --> 00:06:25,840 Speaker 1: all of this, this kind of careerism is compounded by 108 00:06:25,839 --> 00:06:29,599 Speaker 1: the pressure to generate grant funding. So there's this idea 109 00:06:29,720 --> 00:06:33,520 Speaker 1: that more and more scientists are having a bigger percentage 110 00:06:33,520 --> 00:06:38,760 Speaker 1: of their salary covered by contingent or research funding dollars. 111 00:06:38,800 --> 00:06:40,680 Speaker 1: So that means that you now have this pressure to 112 00:06:40,880 --> 00:06:44,960 Speaker 1: keep the flow of funding going with positive results. So 113 00:06:45,000 --> 00:06:46,800 Speaker 1: you can say, yeah, see, this is exactly what I 114 00:06:46,800 --> 00:06:51,640 Speaker 1: thought was going to happen, proving out um. That shouldn't 115 00:06:51,680 --> 00:06:55,640 Speaker 1: be the case. There shouldn't be those sort of strings 116 00:06:55,680 --> 00:06:59,000 Speaker 1: tied to it, and in an ideal world that wouldn't 117 00:06:59,040 --> 00:07:01,680 Speaker 1: be the case. But that's what we're dealing with. And 118 00:07:01,680 --> 00:07:05,279 Speaker 1: then there's this failures to prove hypothesis are actually rarely 119 00:07:05,360 --> 00:07:08,760 Speaker 1: offered for publication, let alone accepted. Uh, you know, and 120 00:07:08,920 --> 00:07:10,920 Speaker 1: you can sort of squirrel away a lot of this 121 00:07:11,080 --> 00:07:14,000 Speaker 1: to you know, what scientific journal doesn't want to be 122 00:07:14,080 --> 00:07:17,000 Speaker 1: on the forefront of science, you know, full of amazing 123 00:07:17,040 --> 00:07:21,040 Speaker 1: new discoveries and and and wonderful new ideas, right that's 124 00:07:21,160 --> 00:07:24,120 Speaker 1: you know, that's really essential to the overall drive of science. 125 00:07:24,120 --> 00:07:26,240 Speaker 1: You don't want to fill your your paper with a 126 00:07:26,240 --> 00:07:29,120 Speaker 1: bunch of failures, right, But the failures are important, right. 127 00:07:29,120 --> 00:07:31,800 Speaker 1: You need to know what hasn't worked so you can 128 00:07:31,800 --> 00:07:33,600 Speaker 1: try and figure out what does work. You need to 129 00:07:33,600 --> 00:07:36,040 Speaker 1: know what's false so you can figure out what's true. Yet, 130 00:07:36,040 --> 00:07:39,240 Speaker 1: in two thousand thirteen, negative results are accounted for only 131 00:07:39,320 --> 00:07:41,680 Speaker 1: fourteen percent of published papers, and that was down from 132 00:07:41,720 --> 00:07:46,600 Speaker 1: thirty in nineteen ninety. And then in a similar vein 133 00:07:46,880 --> 00:07:50,880 Speaker 1: we see the peer of view process UM often sees 134 00:07:51,000 --> 00:07:53,600 Speaker 1: peers missing the errors in the paper. The very thing 135 00:07:53,600 --> 00:07:56,200 Speaker 1: they're supposed to do is, you know, figure out what's 136 00:07:56,240 --> 00:07:59,840 Speaker 1: what's potentially wrong with this work. So both of these 137 00:08:00,040 --> 00:08:04,240 Speaker 1: into handicap the process to a certain extent. You know, 138 00:08:04,360 --> 00:08:08,160 Speaker 1: it's interesting because my daughter's school has nine different design 139 00:08:08,200 --> 00:08:11,440 Speaker 1: principles of education, and there this is something that they 140 00:08:11,480 --> 00:08:14,800 Speaker 1: actually present to the student. So kindergarten reserve being taught 141 00:08:15,320 --> 00:08:20,160 Speaker 1: about failure and actually celebrating failure for this very reason, 142 00:08:20,240 --> 00:08:23,440 Speaker 1: because the idea, again is that you cannot have successes 143 00:08:23,480 --> 00:08:27,240 Speaker 1: without failures. And uh makes me think about Edison and 144 00:08:27,280 --> 00:08:29,920 Speaker 1: the light bulb and the hundred plus iterations of the 145 00:08:30,000 --> 00:08:33,080 Speaker 1: light bulb, all the failures that proceeded those, And yet 146 00:08:33,200 --> 00:08:36,199 Speaker 1: that's not the flashy stuff, right, that's not what necessarily 147 00:08:36,240 --> 00:08:39,240 Speaker 1: a first tier journal is going after. Like, hey, tell 148 00:08:39,240 --> 00:08:42,920 Speaker 1: me about your spectacular failure. Yeah, Like I keep thinking 149 00:08:42,960 --> 00:08:45,800 Speaker 1: about science in terms of slime mold. We did an 150 00:08:45,800 --> 00:08:47,720 Speaker 1: episode on the slime mold way back, where you would 151 00:08:47,720 --> 00:08:50,520 Speaker 1: put a slime mold in a maze, and it's solving 152 00:08:50,559 --> 00:08:52,560 Speaker 1: the maze to get to resources on the outside of 153 00:08:52,559 --> 00:08:55,360 Speaker 1: the maze. And so these tendrils of slime mold or 154 00:08:55,480 --> 00:08:57,319 Speaker 1: trailing through the mazing if they reach a dead end, 155 00:08:57,320 --> 00:08:59,959 Speaker 1: and that tendril dies and fades back and it doesn't 156 00:09:00,000 --> 00:09:02,199 Speaker 1: go down that way again. And science kind of works 157 00:09:02,400 --> 00:09:05,440 Speaker 1: the same way that you need to know which where 158 00:09:05,480 --> 00:09:08,160 Speaker 1: the dead ends are, otherwise you're just gonna keep sending 159 00:09:08,160 --> 00:09:11,800 Speaker 1: your tendils down there. Well. And then it's also this 160 00:09:12,280 --> 00:09:16,400 Speaker 1: such an elegant analogy because they're going after that sugar, right, 161 00:09:16,840 --> 00:09:20,000 Speaker 1: that that resource, and so they're eventually going to find 162 00:09:20,000 --> 00:09:23,280 Speaker 1: themselves to the success story of the resource. But then 163 00:09:23,360 --> 00:09:25,880 Speaker 1: it becomes this question of is that resource that piece 164 00:09:25,880 --> 00:09:29,720 Speaker 1: of sugar that the slime bowl is after. Is this 165 00:09:29,960 --> 00:09:32,840 Speaker 1: truth or is this money? And we'll talk a little 166 00:09:32,880 --> 00:09:35,400 Speaker 1: bit more about that later, but I thought at this 167 00:09:35,440 --> 00:09:37,679 Speaker 1: point I would go ahead and drop in a little 168 00:09:37,679 --> 00:09:42,920 Speaker 1: information about over generalization and extrapolation of results, because this 169 00:09:42,960 --> 00:09:46,400 Speaker 1: can occur in two ways. The first is applying findings 170 00:09:46,440 --> 00:09:49,840 Speaker 1: from one target group to another target group within the 171 00:09:49,880 --> 00:09:53,319 Speaker 1: same population. So an example would be you have this 172 00:09:53,440 --> 00:09:57,720 Speaker 1: new cholesterol drug and it's been tested on females age 173 00:09:58,520 --> 00:10:02,320 Speaker 1: uh it is thirty two fifty. Well, you can't make 174 00:10:02,440 --> 00:10:04,880 Speaker 1: the assumption that the drug can also do the same 175 00:10:04,920 --> 00:10:08,040 Speaker 1: thing for a different population, say women over sixty five 176 00:10:08,200 --> 00:10:12,320 Speaker 1: or men. The second fallacy is applying the survey results 177 00:10:12,320 --> 00:10:14,720 Speaker 1: to population is not living in the area in the survey. 178 00:10:14,800 --> 00:10:17,080 Speaker 1: So this is this to me was very clear cut. 179 00:10:18,240 --> 00:10:20,559 Speaker 1: Let's say that you're trying to establish the mortality rate 180 00:10:20,559 --> 00:10:23,560 Speaker 1: for a certain neighborhood within a zip code. All right, 181 00:10:23,760 --> 00:10:26,120 Speaker 1: you do the research, you do the surveying, and then 182 00:10:26,160 --> 00:10:29,679 Speaker 1: you you've got your data. Now it would be beneficial 183 00:10:29,720 --> 00:10:32,760 Speaker 1: to find out what other neighborhoods mortality rate. But you 184 00:10:32,840 --> 00:10:35,520 Speaker 1: make the assumption that just because the borders of this 185 00:10:35,600 --> 00:10:37,839 Speaker 1: other neighborhood are butting up against the one that you've 186 00:10:37,880 --> 00:10:41,040 Speaker 1: just surveyed, that they have the same mortality rate. Well, 187 00:10:41,080 --> 00:10:43,720 Speaker 1: that is erroneous thinking, because as we know and we 188 00:10:43,760 --> 00:10:46,360 Speaker 1: have seen over and over again you can have really 189 00:10:46,440 --> 00:10:50,560 Speaker 1: poor neighborhoods betting up against very prosperous ones and that 190 00:10:50,640 --> 00:10:52,960 Speaker 1: excuse the data because the very protuluh ones are going 191 00:10:53,000 --> 00:10:56,719 Speaker 1: to have a far different mortality rate than a poor neighborhood. 192 00:10:57,480 --> 00:10:59,959 Speaker 1: And yet these are some of the things that lead 193 00:11:00,080 --> 00:11:03,720 Speaker 1: can with studies and experiments. And then of course there 194 00:11:03,840 --> 00:11:08,360 Speaker 1: is conflict of interest, which is a big one. UH. 195 00:11:08,360 --> 00:11:10,760 Speaker 1: And we can date a lot of this back to 196 00:11:10,880 --> 00:11:13,600 Speaker 1: the Bio Dule Act of nineteen eighty and this came 197 00:11:13,600 --> 00:11:17,600 Speaker 1: along to encourage technology transfer from universities to industry. The 198 00:11:17,600 --> 00:11:22,480 Speaker 1: IDBA being that it would facilitate financial relationships between academic 199 00:11:22,520 --> 00:11:27,719 Speaker 1: biomedical researchers and the biotechnology industry. And you know, obviously 200 00:11:28,200 --> 00:11:30,480 Speaker 1: there's a lot of good that was going to come 201 00:11:30,480 --> 00:11:32,040 Speaker 1: out of this and has come out of this. Uh. 202 00:11:32,400 --> 00:11:35,480 Speaker 1: They leave these uh. These relationships lead to the development 203 00:11:35,480 --> 00:11:39,400 Speaker 1: of improved drugs and medical devices. UH. But on the 204 00:11:39,400 --> 00:11:43,040 Speaker 1: other hand, there's this huge financial aspect of the relationship. 205 00:11:43,040 --> 00:11:46,960 Speaker 1: Of financial relationship emerges relationships that can cause conflicts of 206 00:11:47,000 --> 00:11:51,079 Speaker 1: interest between a researchers scientific and ethical principles and that 207 00:11:51,160 --> 00:11:54,160 Speaker 1: gleam of financial gain coming background to what you said 208 00:11:54,160 --> 00:11:56,280 Speaker 1: about what is the what is the bait on the 209 00:11:56,320 --> 00:11:59,680 Speaker 1: outside of the maze? Is it? Is it knowledge and understanding? 210 00:11:59,800 --> 00:12:03,719 Speaker 1: Is it? Is it increasing our scientific understanding of a 211 00:12:03,760 --> 00:12:07,160 Speaker 1: particular ailment? Or is it mere financial gain? And of course, 212 00:12:07,760 --> 00:12:11,680 Speaker 1: financial gain for a biomedical corporation tends to boil down 213 00:12:11,720 --> 00:12:14,199 Speaker 1: to treatment, the drugs that can be thrown at a 214 00:12:14,200 --> 00:12:16,800 Speaker 1: particular ailment, the medical devices that can be thrown at 215 00:12:16,800 --> 00:12:19,720 Speaker 1: a particular ailment. And in a two thousand nine study 216 00:12:19,760 --> 00:12:24,440 Speaker 1: from Dr Rueschmajas, Assistant Professor of Radiation Oncology at the 217 00:12:24,480 --> 00:12:28,360 Speaker 1: University of Michigan Medical School, compared a thousand, five thirty 218 00:12:28,360 --> 00:12:32,760 Speaker 1: four studies involving cancer research, found that studies with with 219 00:12:32,920 --> 00:12:37,920 Speaker 1: industry funding focused on treatment again drugs, medical devices sixty 220 00:12:38,480 --> 00:12:41,000 Speaker 1: of the time compared to thirty six percent of the 221 00:12:41,040 --> 00:12:44,800 Speaker 1: time for other studies not funded by industry, and the 222 00:12:44,840 --> 00:12:49,360 Speaker 1: studies funded by industry focused on epidemiology, prevention, risk factors, 223 00:12:49,400 --> 00:12:53,120 Speaker 1: screening and other diagnostic methods only twenty percent of the 224 00:12:53,160 --> 00:12:57,720 Speaker 1: time versus forty seven for studies with no declared industry funding. 225 00:12:57,800 --> 00:13:01,520 Speaker 1: So the take home here seems to be the more 226 00:13:01,640 --> 00:13:05,560 Speaker 1: money is involved from these from the biotech industry. The 227 00:13:05,640 --> 00:13:08,840 Speaker 1: more focus there is going to be on the mere 228 00:13:08,880 --> 00:13:12,040 Speaker 1: treatment of an ailment versus uh um, you know, actually 229 00:13:12,080 --> 00:13:15,560 Speaker 1: being able to prevent it or figure out how to 230 00:13:15,600 --> 00:13:19,280 Speaker 1: screen it through looking at risk factors, which my lead 231 00:13:19,320 --> 00:13:23,640 Speaker 1: to misleading statistics or interpretation about the data. And what 232 00:13:23,760 --> 00:13:27,960 Speaker 1: I'm talking about is absolute versus relative percentages. This is 233 00:13:28,040 --> 00:13:32,120 Speaker 1: from the article bad Science, Common Problems and research Articles. 234 00:13:32,120 --> 00:13:35,560 Speaker 1: This was published on Health Readings. Quote supposed that there 235 00:13:35,679 --> 00:13:38,880 Speaker 1: was a medical problem that caused two people in one 236 00:13:38,960 --> 00:13:41,880 Speaker 1: million to have a stroke, and suppose there was a 237 00:13:41,920 --> 00:13:45,080 Speaker 1: treatment that would reduce the problem to only one person 238 00:13:45,480 --> 00:13:48,360 Speaker 1: in one million. This would be an improvement of point 239 00:13:48,520 --> 00:13:53,880 Speaker 1: zero zero zero one percent in an absolute sense, or 240 00:13:54,240 --> 00:13:57,640 Speaker 1: or as this author says, no big deal, right. However, 241 00:13:58,440 --> 00:14:03,120 Speaker 1: if it had been hoarded using relative percentages, it could 242 00:14:03,160 --> 00:14:07,960 Speaker 1: have been stated quote new medical treatment yields a rediction 243 00:14:08,160 --> 00:14:11,560 Speaker 1: and reduction and risk of stroke, and this would be 244 00:14:11,640 --> 00:14:15,600 Speaker 1: very misleading. But it's unfortunately a common practice that you 245 00:14:15,640 --> 00:14:18,400 Speaker 1: see from time to time, and so again you see 246 00:14:18,440 --> 00:14:22,080 Speaker 1: how that's it's not exactly wrong. It is a fifty 247 00:14:22,360 --> 00:14:27,280 Speaker 1: percent reduction in the two and one million people, but 248 00:14:27,360 --> 00:14:31,680 Speaker 1: it's not really accurate saying. It's just how how do 249 00:14:31,720 --> 00:14:34,040 Speaker 1: you end up using? How the effect the overall statistics 250 00:14:34,160 --> 00:14:39,520 Speaker 1: that you're dealing with. Yeah, semantics matter. Now. Another area 251 00:14:39,600 --> 00:14:43,360 Speaker 1: of concern is that of unpublished clinical trials. A two 252 00:14:43,360 --> 00:14:46,720 Speaker 1: thousand twelve study from Yale School of Medicine researchers found 253 00:14:46,760 --> 00:14:50,160 Speaker 1: that fewer than half of a sample of trials primarily 254 00:14:50,240 --> 00:14:53,040 Speaker 1: or partially funded by the National Institutes of Health were 255 00:14:53,040 --> 00:14:56,560 Speaker 1: published within thirty months of completing the clinical trial. So, 256 00:14:56,600 --> 00:14:59,720 Speaker 1: in other words, the research refindings here are not being 257 00:15:00,000 --> 00:15:03,800 Speaker 1: emanated half the time, So the scientific process is disrupted, 258 00:15:04,000 --> 00:15:07,840 Speaker 1: undermining the effort and the available material for peer of view. Now, 259 00:15:07,920 --> 00:15:11,160 Speaker 1: according to study author Dr Joseph Ross, they're probably a 260 00:15:11,240 --> 00:15:14,000 Speaker 1: number of reasons for lack of publication, such as not 261 00:15:14,000 --> 00:15:16,120 Speaker 1: getting accepted by a journal and we already hit on 262 00:15:16,160 --> 00:15:20,240 Speaker 1: the high rejection rates, or not prioritizing the dissemination of 263 00:15:20,280 --> 00:15:25,400 Speaker 1: research findings in the study. Either way, this disrupts the process. 264 00:15:25,440 --> 00:15:29,600 Speaker 1: This disrupts the strengths of the peer of view system. 265 00:15:29,640 --> 00:15:35,360 Speaker 1: Another factor is something called selective observation. Now, you've probably 266 00:15:35,400 --> 00:15:41,000 Speaker 1: experienced your own selective observation before. My example is every 267 00:15:41,000 --> 00:15:44,880 Speaker 1: time I get into the shower of my phone rings, right. Uh, 268 00:15:44,880 --> 00:15:47,000 Speaker 1: and it's a perception that is based on the annoyance 269 00:15:47,000 --> 00:15:49,680 Speaker 1: of my phone ringing and my inability to get to it. 270 00:15:50,960 --> 00:15:54,600 Speaker 1: But then I, you know, I tended to disregard all 271 00:15:54,640 --> 00:15:56,680 Speaker 1: the times that my phone didn't ring well as in 272 00:15:56,760 --> 00:15:59,680 Speaker 1: the shower, and so I was practicing confirmation biased and 273 00:16:00,080 --> 00:16:04,760 Speaker 1: oring the other data, skewing my own statistics. So selective 274 00:16:04,760 --> 00:16:07,840 Speaker 1: observation in science is essentially trying to land on a 275 00:16:07,880 --> 00:16:11,960 Speaker 1: conclusion based on an existing bias or belief. For example, 276 00:16:12,400 --> 00:16:14,840 Speaker 1: a researcher who studying obesity may have a bias that 277 00:16:14,920 --> 00:16:18,720 Speaker 1: obese people lack will power, and as a result, they 278 00:16:18,760 --> 00:16:21,920 Speaker 1: may construct an experiment that involved a plate of donuts 279 00:16:21,920 --> 00:16:25,040 Speaker 1: and a conference froom work. But if that researcher only 280 00:16:25,080 --> 00:16:29,840 Speaker 1: records data about ABS subjects and doesn't record non ABS subjects, well, 281 00:16:29,920 --> 00:16:32,600 Speaker 1: then they have a biased experiment on their hands. In 282 00:16:32,600 --> 00:16:35,600 Speaker 1: other words, Uh, if they don't go out of their 283 00:16:35,640 --> 00:16:39,119 Speaker 1: way to try to prove themselves wrong, they're not exercising 284 00:16:39,120 --> 00:16:42,960 Speaker 1: the principles of scientific method. All right, you know, let's 285 00:16:42,960 --> 00:16:45,480 Speaker 1: take a quick break and when we come back we 286 00:16:45,520 --> 00:16:58,560 Speaker 1: will discuss weird science. All right, we're back. Weird science, 287 00:16:58,840 --> 00:17:03,760 Speaker 1: weird psychology, and I'm not talking about the eighties classic 288 00:17:03,840 --> 00:17:07,480 Speaker 1: as it is. Um No, weird is a phenomenon that 289 00:17:07,520 --> 00:17:10,440 Speaker 1: plagues a lot of psychology and other social science studies. 290 00:17:10,840 --> 00:17:14,120 Speaker 1: This is when the Protestants are overwhelmingly This is where 291 00:17:14,160 --> 00:17:18,800 Speaker 1: weird comes in Western E for educated, and they're from 292 00:17:19,320 --> 00:17:23,840 Speaker 1: I for industrialized, ARE for rich, and D for democratic countries. 293 00:17:24,000 --> 00:17:29,720 Speaker 1: So weird humans are serving as the basic test subjects 294 00:17:29,840 --> 00:17:32,560 Speaker 1: in a lot of these studies. And you can also 295 00:17:32,720 --> 00:17:36,480 Speaker 1: add in that weird humans are also often college students 296 00:17:36,720 --> 00:17:41,200 Speaker 1: in the United States, participating in studies for class credit. So, 297 00:17:41,440 --> 00:17:44,600 Speaker 1: especially in the social sciences, the risk is that so 298 00:17:44,680 --> 00:17:48,959 Speaker 1: called weird populations are actually the outliers of human population 299 00:17:49,240 --> 00:17:52,520 Speaker 1: as opposed to a good standard example of human behavior. 300 00:17:53,040 --> 00:17:55,680 Speaker 1: And you know, you see this, You see shades of 301 00:17:55,760 --> 00:17:57,040 Speaker 1: this time and time again. Right. You look at a 302 00:17:57,080 --> 00:17:59,280 Speaker 1: study and it was clearly a study that was conducted 303 00:18:00,040 --> 00:18:04,760 Speaker 1: on campus with students, and in your better studies you 304 00:18:04,800 --> 00:18:08,200 Speaker 1: see them branching out from that and saying, uh um, well, 305 00:18:08,280 --> 00:18:10,040 Speaker 1: all right, when this first study we looked at students, 306 00:18:10,080 --> 00:18:12,719 Speaker 1: but then we went into an impoverished neighborhood or in 307 00:18:12,720 --> 00:18:16,000 Speaker 1: some cases, then we looked at some US participants. Then 308 00:18:16,000 --> 00:18:18,080 Speaker 1: when we also went and looked at some participants in 309 00:18:18,160 --> 00:18:21,880 Speaker 1: Hong Kong, that sort of thing. Um. And so obviously 310 00:18:21,920 --> 00:18:23,680 Speaker 1: there are a lot there's a lot to consider here 311 00:18:23,920 --> 00:18:26,639 Speaker 1: with the software of psychology, right, because there's so much 312 00:18:26,640 --> 00:18:30,240 Speaker 1: about human culture and uh and in your relations within 313 00:18:30,320 --> 00:18:33,800 Speaker 1: your particular group. But it also bleeds into the hardware 314 00:18:33,880 --> 00:18:38,920 Speaker 1: of physiology. In two thousand fourteen, Liverpool University had a 315 00:18:38,960 --> 00:18:43,520 Speaker 1: study examining rapid eye movements called cicades among groups of 316 00:18:43,760 --> 00:18:48,639 Speaker 1: mainland Chinese, British Chinese, and white British test subjects, and 317 00:18:48,640 --> 00:18:51,640 Speaker 1: he found that Chinese ethnicity was more of a factor 318 00:18:51,680 --> 00:18:55,919 Speaker 1: than culture in high cicade counts. So the mainland Chinese 319 00:18:55,960 --> 00:18:59,600 Speaker 1: groups scored high cicade numbers as did the British Chinese counterparts, 320 00:19:00,119 --> 00:19:03,760 Speaker 1: despite the many cultural differences between the two groups. So 321 00:19:04,800 --> 00:19:08,200 Speaker 1: lead author Dr Paul Knox argued, quote, the human brain 322 00:19:08,359 --> 00:19:12,320 Speaker 1: is not just amazingly complex in general, but also highly 323 00:19:12,440 --> 00:19:18,960 Speaker 1: variable across the human population. Mm hmm. And that variability 324 00:19:19,280 --> 00:19:23,120 Speaker 1: takes us to the next entry here, which is animals. Now, 325 00:19:23,160 --> 00:19:28,080 Speaker 1: we have talked about how much rodents have um contributed 326 00:19:28,119 --> 00:19:31,680 Speaker 1: to science, and they absolutely have, but we do have 327 00:19:31,800 --> 00:19:37,840 Speaker 1: problems where animal studies do not reliably predict human outcomes. 328 00:19:38,480 --> 00:19:40,840 Speaker 1: And this topic is really a complex one, but there's 329 00:19:40,840 --> 00:19:44,080 Speaker 1: a paper on the topic by Michael B. Bracken who's 330 00:19:44,119 --> 00:19:47,480 Speaker 1: from Yale University, and he writes in his paper why 331 00:19:47,560 --> 00:19:50,119 Speaker 1: animal studies are often poor predictors of human reactions to 332 00:19:50,160 --> 00:19:54,879 Speaker 1: exposure that one reason is probably because animal experiments do 333 00:19:55,000 --> 00:19:58,080 Speaker 1: not translate into replications, and human trials are into cancer 334 00:19:58,160 --> 00:20:04,680 Speaker 1: chemoprevention because as they're poorly designed, conducted, and analyzed. Now, 335 00:20:04,720 --> 00:20:07,919 Speaker 1: another possible contribution to failure to replicate the results of 336 00:20:08,040 --> 00:20:12,359 Speaker 1: animal research and humans is that reviews and summaries of 337 00:20:12,440 --> 00:20:16,840 Speaker 1: evidence from animal research are inadequate when it comes to methodology, 338 00:20:16,960 --> 00:20:20,560 Speaker 1: and one survey, only one in ten thousand Meadline records 339 00:20:20,600 --> 00:20:23,879 Speaker 1: of animal studies were tagged as being meta analysis, is 340 00:20:24,359 --> 00:20:28,520 Speaker 1: compared to one and one thousand human studies, and in 341 00:20:28,640 --> 00:20:32,399 Speaker 1: recent reports, the poor quality of research was documented by 342 00:20:32,400 --> 00:20:35,200 Speaker 1: a comprehensive search of Medline, which found only twenty five 343 00:20:35,480 --> 00:20:40,600 Speaker 1: systematic reviews of animal research. Other studies similarly found only 344 00:20:40,760 --> 00:20:44,359 Speaker 1: thirty and fifty seven systematic reviews of any type of 345 00:20:44,400 --> 00:20:48,840 Speaker 1: animal researcher so Um. The reason that Bracken points us 346 00:20:48,840 --> 00:20:51,760 Speaker 1: out is because he says these kind of deficiencies are 347 00:20:51,840 --> 00:20:57,280 Speaker 1: important because animal research often provides the rationale for hypotheses 348 00:20:57,359 --> 00:21:02,200 Speaker 1: studied by epidemiologists and clinical researchers. Moreover, if you look 349 00:21:02,240 --> 00:21:06,280 Speaker 1: at the genetics of this, it gets even more muddled. 350 00:21:06,440 --> 00:21:09,560 Speaker 1: And the reason for that is because with rodents, and 351 00:21:09,600 --> 00:21:11,160 Speaker 1: one of the reasons why we use them is because 352 00:21:11,200 --> 00:21:15,280 Speaker 1: we can change their genetic background within a couple of generations. 353 00:21:15,400 --> 00:21:19,640 Speaker 1: We can tinker with the genes. And that's great because 354 00:21:19,680 --> 00:21:24,640 Speaker 1: that can really help us to study certain conditions. However, Um, 355 00:21:24,800 --> 00:21:29,800 Speaker 1: those rodents would yield really consistent results and disease expression. 356 00:21:30,840 --> 00:21:33,960 Speaker 1: But humans, we are far more wild West when it 357 00:21:34,000 --> 00:21:37,720 Speaker 1: comes to genetics and the genetic background, and that would 358 00:21:37,800 --> 00:21:40,639 Speaker 1: factor in how the human disease is expressed, and this 359 00:21:40,680 --> 00:21:46,200 Speaker 1: would yield a mismatching results between humans and animals. It's 360 00:21:46,200 --> 00:21:50,680 Speaker 1: a layer cake of animal confusion. Indeed, it is um. Now, 361 00:21:50,720 --> 00:21:53,560 Speaker 1: on top of everything we've discussed here, there are plenty 362 00:21:53,600 --> 00:21:57,879 Speaker 1: of additional methodological pitfalls, and we're we're gonna include a 363 00:21:58,000 --> 00:22:00,199 Speaker 1: link on the landing page of this episode to a 364 00:22:00,200 --> 00:22:02,640 Speaker 1: fabulous page that has a list of about sixty of them, 365 00:22:02,960 --> 00:22:04,600 Speaker 1: and we're not going to go into all into detail 366 00:22:04,600 --> 00:22:05,680 Speaker 1: on all of them here, but just to give you 367 00:22:05,720 --> 00:22:08,479 Speaker 1: an example, this includes the likes of the cebo effect, 368 00:22:08,520 --> 00:22:12,400 Speaker 1: which we've discussed at length before, and in which the 369 00:22:12,400 --> 00:22:17,480 Speaker 1: the individual receiving the sugar pill ends up actually getting 370 00:22:17,560 --> 00:22:21,159 Speaker 1: some sort of biological benefit from from the medication or 371 00:22:21,160 --> 00:22:24,960 Speaker 1: the fake medication, uh carry over effect, where the results 372 00:22:24,960 --> 00:22:29,159 Speaker 1: of one study are are observed in a secondary study 373 00:22:29,600 --> 00:22:32,639 Speaker 1: without realizing it. And then magnitude blindness, the tendency to 374 00:22:32,680 --> 00:22:38,040 Speaker 1: become preoccupied with statistically significant results that never nevertheless have 375 00:22:38,119 --> 00:22:41,240 Speaker 1: a small magnitude on effect. I feel like that comes 376 00:22:41,280 --> 00:22:45,320 Speaker 1: into play a lot when I look at, um, some 377 00:22:45,400 --> 00:22:48,080 Speaker 1: of this stuff that's new and that's being reported in 378 00:22:48,080 --> 00:22:50,280 Speaker 1: the media. It's very exciting, right, you know, oh wow, 379 00:22:50,359 --> 00:22:52,440 Speaker 1: look at this insight, and then when you get into 380 00:22:52,440 --> 00:22:56,879 Speaker 1: the specifics of the study, it's just it's not that significant, right, 381 00:22:57,000 --> 00:23:00,639 Speaker 1: doesn't quite match up to that snappy headline. All right, 382 00:23:00,720 --> 00:23:03,960 Speaker 1: So how does science correct course? What can be done 383 00:23:03,960 --> 00:23:08,720 Speaker 1: about these problems we've discussed? Well, um, just to talk 384 00:23:09,040 --> 00:23:13,520 Speaker 1: briefly about the use of statistics and managing potential conflicts, 385 00:23:13,760 --> 00:23:17,600 Speaker 1: those financial conflicts we we mentioned earlier, conflicts of interest. Um. 386 00:23:17,640 --> 00:23:20,159 Speaker 1: The general idea that the expert put put forth is 387 00:23:20,200 --> 00:23:23,800 Speaker 1: that we need to simplify, standardized and better enforced policies 388 00:23:23,840 --> 00:23:27,960 Speaker 1: to manage financial conflicts of interest, and that science needs 389 00:23:28,000 --> 00:23:30,479 Speaker 1: to keep a better eye on statistics, by which we mean, 390 00:23:30,520 --> 00:23:34,120 Speaker 1: of course, the statistical validity and the statistical errors inherent 391 00:23:34,200 --> 00:23:37,840 Speaker 1: in the system. Another thing is to encourage replication. And 392 00:23:37,880 --> 00:23:41,120 Speaker 1: again this is from the Economist article quote. Some government 393 00:23:41,119 --> 00:23:45,879 Speaker 1: funding agencies, including America's National Institutes of Health, which dish 394 00:23:45,920 --> 00:23:49,240 Speaker 1: out thirty billion on research each year, are working out 395 00:23:49,240 --> 00:23:52,800 Speaker 1: how to best encourage replication and growing numbers of scientists, 396 00:23:52,880 --> 00:23:58,880 Speaker 1: especially young ones, understand statistics. Another area is allocating space 397 00:23:59,119 --> 00:24:03,119 Speaker 1: and journals were uninteresting studies, which which is which is 398 00:24:03,119 --> 00:24:05,399 Speaker 1: crazy because if you think about it in terms of, say, um, 399 00:24:05,640 --> 00:24:08,040 Speaker 1: you know, a literary fiction publication, you would never in 400 00:24:08,040 --> 00:24:10,880 Speaker 1: a million years have anyone suggests, hey, we should make 401 00:24:11,000 --> 00:24:14,760 Speaker 1: room in this, uh this review for bad fiction. You 402 00:24:14,760 --> 00:24:16,480 Speaker 1: know a certain amount that we're always just gonna include 403 00:24:16,520 --> 00:24:19,360 Speaker 1: bad fiction. But the idea here is that scientific journals 404 00:24:19,359 --> 00:24:23,240 Speaker 1: should allocate space for the less jazzy, the less sexy stuff, 405 00:24:23,240 --> 00:24:27,359 Speaker 1: because that too is essential. Now I'm wishing for a 406 00:24:27,440 --> 00:24:33,440 Speaker 1: journal called the humdrum Studies Journal, uninteresting Studies Journal. Now, 407 00:24:33,440 --> 00:24:38,600 Speaker 1: another solution would be to tighten peer reviews, so perhaps 408 00:24:38,640 --> 00:24:41,560 Speaker 1: dispensing with it altogether. And again that's from the Economist article. 409 00:24:42,160 --> 00:24:44,720 Speaker 1: And so if you dispense with it altogether, what would 410 00:24:44,800 --> 00:24:48,159 Speaker 1: do well? You would have post publication evaluation in the 411 00:24:48,200 --> 00:24:52,439 Speaker 1: form of appended comments. And they say that that system 412 00:24:52,520 --> 00:24:55,160 Speaker 1: has worked well in recent years in physics and mathematics. 413 00:24:55,200 --> 00:24:59,280 Speaker 1: And lastly, policymakers should ensure the institutions using public money 414 00:24:59,320 --> 00:25:03,679 Speaker 1: also aspect the rules. So picking up again to the 415 00:25:03,680 --> 00:25:06,080 Speaker 1: potholes that we had mentioned, one of them is also 416 00:25:06,200 --> 00:25:10,320 Speaker 1: skills neglect, and this is that human disposition to resist 417 00:25:10,480 --> 00:25:13,439 Speaker 1: learning new scholarly methods that may be pertinent to a 418 00:25:13,440 --> 00:25:17,359 Speaker 1: research problem. And so that would also factor into peer review. 419 00:25:17,560 --> 00:25:20,399 Speaker 1: Is just making sure that while you're reviewing something else, 420 00:25:20,520 --> 00:25:23,439 Speaker 1: but your own knowledge of the topic is up to snuff. 421 00:25:23,840 --> 00:25:27,040 Speaker 1: And finally, when it comes to weird populations, I mean, 422 00:25:27,480 --> 00:25:29,199 Speaker 1: the big thing is just to be aware of it 423 00:25:29,240 --> 00:25:32,280 Speaker 1: too when you're when you're sampling, when you're using samples 424 00:25:32,520 --> 00:25:36,359 Speaker 1: from the immediate collegiate environment to be aware of it 425 00:25:36,400 --> 00:25:40,679 Speaker 1: and maybe be less cavalier about uh saying that you 426 00:25:40,720 --> 00:25:43,480 Speaker 1: have identified something that is in you know, basic in 427 00:25:43,560 --> 00:25:49,360 Speaker 1: general human nature. Of course, we should end this episode 428 00:25:50,080 --> 00:25:56,160 Speaker 1: with the study of all studies, which is that there 429 00:25:56,200 --> 00:25:59,680 Speaker 1: are too many studies. Yes, this was I believe that 430 00:25:59,760 --> 00:26:02,879 Speaker 1: the time it was attention decay in science, um, which 431 00:26:03,040 --> 00:26:06,680 Speaker 1: is snazzy. UM. And it basically just comes down to 432 00:26:06,680 --> 00:26:08,560 Speaker 1: the fact that there are just so many studies coming 433 00:26:08,560 --> 00:26:11,680 Speaker 1: out now in so many journals. They've just exploded since 434 00:26:11,760 --> 00:26:16,000 Speaker 1: the earlier days um, in the twentieth century. Yeah, and 435 00:26:16,040 --> 00:26:18,600 Speaker 1: it's hard for everyone to keep up with the studies, 436 00:26:18,640 --> 00:26:21,359 Speaker 1: and also the older studies are getting lost in the 437 00:26:21,359 --> 00:26:24,359 Speaker 1: fray of new studies. So um. Of course you know 438 00:26:24,400 --> 00:26:28,719 Speaker 1: that building upon knowledge is really important in this discovery 439 00:26:28,760 --> 00:26:31,959 Speaker 1: of truth. Right, And it's fair to point out that 440 00:26:32,000 --> 00:26:37,400 Speaker 1: this paper should awesome also be analyzed, um because it's 441 00:26:37,440 --> 00:26:40,919 Speaker 1: just one single study and the researchers mainly looked at 442 00:26:41,040 --> 00:26:44,680 Speaker 1: very broad fields like chemistry and medicine. Indeed, trust but 443 00:26:44,920 --> 00:26:50,679 Speaker 1: verify right, it all comes back. So so again, this 444 00:26:50,920 --> 00:26:54,439 Speaker 1: episode wasn't It's not about you know, doubt everything, doubt 445 00:26:54,440 --> 00:26:57,480 Speaker 1: every study, that comes out, doubt every the bit of 446 00:26:57,640 --> 00:27:01,440 Speaker 1: science journalism that comes across your desk, But it's it's all. 447 00:27:02,560 --> 00:27:05,080 Speaker 1: It's all information that's worth keeping in mind when you 448 00:27:05,160 --> 00:27:08,560 Speaker 1: do engage with these studies. Uh, and something that you 449 00:27:08,600 --> 00:27:10,679 Speaker 1: know that we like to keep in mind, you know, 450 00:27:10,680 --> 00:27:13,000 Speaker 1: when we look at these studies in our research. Yeah, 451 00:27:13,040 --> 00:27:15,600 Speaker 1: and we thought that this was pertinent information, especially when 452 00:27:15,640 --> 00:27:18,880 Speaker 1: you consider how much data we are taking in every 453 00:27:18,880 --> 00:27:22,280 Speaker 1: single day and all of the headlines that are connected 454 00:27:22,320 --> 00:27:24,520 Speaker 1: to these studies and where they're coming from and how 455 00:27:24,520 --> 00:27:28,679 Speaker 1: they're being pursed out. Indeed, Hey, in the meantime, if 456 00:27:28,680 --> 00:27:30,920 Speaker 1: you want to check out more episodes of Stuff to 457 00:27:30,920 --> 00:27:34,639 Speaker 1: Blow your Mind, most of which involve scientific studies of 458 00:27:34,680 --> 00:27:37,000 Speaker 1: one type or another, you can head on over to 459 00:27:37,000 --> 00:27:39,280 Speaker 1: stuff to Blow your Mind dot com, where you will 460 00:27:39,320 --> 00:27:42,640 Speaker 1: find all those podcast episodes, all those videos, all those 461 00:27:42,640 --> 00:27:45,199 Speaker 1: blog posts, you name it. And we know some of 462 00:27:45,240 --> 00:27:47,399 Speaker 1: you are out there toiling away in the fields and 463 00:27:47,400 --> 00:27:51,520 Speaker 1: the labs, scientific researchers. Do you have thoughts about this? 464 00:27:52,320 --> 00:27:53,879 Speaker 1: If so, we would love to hear from you, and 465 00:27:53,920 --> 00:27:55,800 Speaker 1: you can email us at blow the Mind at house 466 00:27:55,840 --> 00:28:01,680 Speaker 1: to courts dot com for more on this and thousands 467 00:28:01,680 --> 00:28:10,000 Speaker 1: of other topics, visit how stuff works dot com.