WEBVTT - Cannabis Files: Medical Marijuana 0:00:01.240 --> 0:00:05.880 Welcome to Stuff to Blow Your Mind from how Stop 0:00:05.880 --> 0:00:14.560 Work dot com. Hey, welcome to Stuff to Blow your Mind. 0:00:14.560 --> 0:00:17.040 My name is Robert Lamb and I'm Christian Seger, and 0:00:17.079 --> 0:00:21.639 this is the second part of our Cannabis Files. Episode. 0:00:22.600 --> 0:00:26.000 We're taking a deep look at the science behind marijuana, 0:00:26.160 --> 0:00:29.200 and in particular in this episode, we're going to focus 0:00:29.240 --> 0:00:33.760 on its medical applications. Uh. And the thing about medical 0:00:33.800 --> 0:00:38.120 applications with marijuana that's interesting is we've known about them 0:00:38.200 --> 0:00:42.800 for a very long time. This isn't something new, right, Like, 0:00:42.840 --> 0:00:45.640 you've only heard the term medical marijuana and maybe what 0:00:45.840 --> 0:00:47.760 like the last twenty or thirty years here in the 0:00:47.840 --> 0:00:51.279 United States, But this goes back thousands of years. Yeah. 0:00:51.320 --> 0:00:54.200 I feel like it's easy to to sort of to 0:00:54.320 --> 0:00:57.120 hear about medical marijuana. So we're certainly to have heard 0:00:57.120 --> 0:00:59.840 about it earlier on and think to yourself, Oh, this 0:00:59.880 --> 0:01:04.840 is just marijuana users trying to legitimize their recreational use 0:01:04.880 --> 0:01:07.960 by saying, oh, it's actually good for you. But but 0:01:07.959 --> 0:01:11.600 but really, our our relationship with the medicinal marijuana goes 0:01:11.640 --> 0:01:13.920 back for a long time. Yeah, So we're gonna give 0:01:13.959 --> 0:01:16.479 you a little bit more than Doug Benson's super high 0:01:16.480 --> 0:01:19.560 med documentary here. Uh, this is gonna be you know, 0:01:19.720 --> 0:01:22.360 a real deep look at the earliest known medical uses 0:01:22.440 --> 0:01:27.000 of medical marijuana and then the actual beneficial properties of 0:01:27.160 --> 0:01:29.920 cannabis in the ways that we're researching it right now, 0:01:29.959 --> 0:01:32.640 because we're you know, as far even though as far 0:01:32.720 --> 0:01:35.120 back as it goes, we don't we haven't really nailed 0:01:35.120 --> 0:01:37.880 it down right at least in the empirical since Yeah, 0:01:37.920 --> 0:01:40.440 so this is there are a lot of open questions here. 0:01:41.080 --> 0:01:43.840 As we mentioned in our last episode, you could easily 0:01:43.880 --> 0:01:48.320 do an entire podcast series, um just looking at all 0:01:48.440 --> 0:01:51.960 the different research um examples out there and all the 0:01:51.960 --> 0:01:55.240 different applications. Uh, and all we're trying to do is 0:01:55.240 --> 0:01:59.640 given a nice overview with some some detailed discussion where 0:01:59.640 --> 0:02:02.640 it makes sense. As always, if there's an area that 0:02:02.720 --> 0:02:04.760 you want more clarification on, you have a couple of 0:02:04.800 --> 0:02:08.480 different options. You can check out that how medical Marijuana 0:02:08.520 --> 0:02:10.680 article works over how stuff works dot com. You can 0:02:10.720 --> 0:02:14.080 also let us know, Hey, why don't you do a different, 0:02:14.320 --> 0:02:17.160 like an entire episode just on this one little area 0:02:17.680 --> 0:02:19.960 consider doing. Yeah, yeah, it would be great if you 0:02:20.040 --> 0:02:24.040 let us know what particular you know, subsect of this 0:02:24.320 --> 0:02:27.120 uh information that you'd like us to go a little 0:02:27.160 --> 0:02:29.440 further down. I mean, when we're doing the research or 0:02:29.480 --> 0:02:34.160 something like this, we really have to keep the net wide. Now. 0:02:34.160 --> 0:02:36.359 In our last episode, when we were talking about just 0:02:36.840 --> 0:02:41.320 humanity's long history with marijuana and how it how cannabis 0:02:41.639 --> 0:02:45.840 originated in uh in perhaps India or Central Asia and 0:02:45.880 --> 0:02:49.720 it's just spread out from there over the over the 0:02:49.840 --> 0:02:54.359 over thousands of years, we mentioned that the earliest written 0:02:54.400 --> 0:02:59.640 account goes back to WHATCS something that's twenty eight maybe, 0:02:59.639 --> 0:03:02.760 but yeah, it's like, well, very long time. And uh 0:03:03.040 --> 0:03:05.079 so you might have been wondering them like who, what's 0:03:05.120 --> 0:03:08.040 the details on this? Who? Who wrote what? Well, I 0:03:08.040 --> 0:03:10.639 am here to tell you the the writer in this 0:03:10.680 --> 0:03:15.680 case is the mythical Emperor shinng Uh, the divine farmer 0:03:15.760 --> 0:03:19.840 and founder of Chinese herbal medicine, really the founder of 0:03:20.240 --> 0:03:24.680 Chinese medicine in general. And uh he allegedly, and I 0:03:24.680 --> 0:03:27.239 say allegedly, because he's a very much a mythological figure, 0:03:27.400 --> 0:03:31.120 becomes just sort of lost to history to what extent 0:03:31.200 --> 0:03:34.720 this is real person, myth was a combination of people 0:03:34.800 --> 0:03:36.880 or something like that exactly, because yeah, he's a very 0:03:36.880 --> 0:03:40.000 he's a divine figure in in Chinese history, and it's 0:03:40.360 --> 0:03:42.400 like maybe thousands of years from now people will say 0:03:42.400 --> 0:03:45.200 that about Alexander Shulgin. They're like, surely this person couldn't 0:03:45.200 --> 0:03:50.520 have existed. Shogan the Great, Yeah, the divine architect of M. 0:03:50.600 --> 0:03:54.720 D M A M. But according to so so, basically 0:03:54.920 --> 0:03:59.800 Shinng wrote the Shinng Bin Kao Jing or the g 0:04:00.040 --> 0:04:04.760 eight herbal. He wrote this around BC, and according to myth, 0:04:05.840 --> 0:04:10.600 Sheinong either tasted hundreds of herbs or thrash them with 0:04:10.640 --> 0:04:14.000 a magic whip in order to learn their properties. I'm 0:04:14.000 --> 0:04:17.040 gonna go the tasting, although that would that would be 0:04:17.080 --> 0:04:18.800 like like let's say you're in a D and D 0:04:18.960 --> 0:04:21.240 campaign and you find an item and they're like it's 0:04:21.279 --> 0:04:23.720 a magic whip and you cast your identified spell and 0:04:23.720 --> 0:04:28.200 they're like, it can tell you the properties of marijuana. Yeah, 0:04:28.640 --> 0:04:30.120 it would be a useful item to having a role 0:04:30.160 --> 0:04:33.720 playing campaigns that poison. I don't know, let me there 0:04:33.760 --> 0:04:36.359 you go, it's the detect poison whip. Okay. But this 0:04:36.440 --> 0:04:38.599 also drives home just sort of the mythical nature of 0:04:38.600 --> 0:04:44.000 Shinong real person, uh, divine figure, some you know, convergence 0:04:44.000 --> 0:04:47.800 of the two. Uh you know, he's really both. Now, 0:04:47.800 --> 0:04:50.400 according to one of the legends that involved in actually 0:04:50.440 --> 0:04:54.320 sampling the herbs, he once consumes seventy poisons in a 0:04:54.400 --> 0:04:57.920 single day in order to bring our herbal medicine into 0:04:57.960 --> 0:05:01.600 the world. Okay, so he you know, that sounds on 0:05:01.600 --> 0:05:03.159 one level a little more relatable. But then on the 0:05:03.160 --> 0:05:05.440 other seventy poisons in a day would surely be enough 0:05:05.480 --> 0:05:09.039 to kill a normal mortal. So yeah, well that whip 0:05:09.120 --> 0:05:12.520 he was able to tell exactly how much he could take. 0:05:13.920 --> 0:05:17.120 So the book in question says that if taken in excess, 0:05:17.480 --> 0:05:22.120 cannabis quote will produce hallucinations you've taken over a long term, 0:05:22.200 --> 0:05:26.400 it makes one communicate with spirits and lightens one's body. 0:05:26.440 --> 0:05:29.880 And I think that based on the the the different 0:05:30.400 --> 0:05:35.240 psychological and physical effects that can occur with marijuana use. Uh, 0:05:35.360 --> 0:05:38.800 that sounds like sheong hit the nail round in the head. Yeah. 0:05:38.960 --> 0:05:43.800 I never had any of the communicating with spirits applications 0:05:43.880 --> 0:05:46.280 or symptoms, but that sounds like it would have been. 0:05:46.560 --> 0:05:49.000 That sounds like if there was like a cultural sort 0:05:49.040 --> 0:05:53.000 of uh surrounding that, Like communicating with spirits is a 0:05:53.040 --> 0:05:57.160 regular thing, right that you would of course, Yeah, it 0:05:57.320 --> 0:06:01.000 was already a script for it because based on the 0:06:01.000 --> 0:06:03.200 research I was looking at like, there's no there's no 0:06:03.279 --> 0:06:07.920 real sign of actual hallucination occurring in and of itself, 0:06:08.000 --> 0:06:12.839 unrelated to other symptoms, underlying symptoms or psychological conditions or 0:06:12.920 --> 0:06:17.040 other substances with cannabis. Now, might you close your eyes 0:06:17.040 --> 0:06:20.840 and see cartoon characters? Very posts depends on you strong 0:06:20.880 --> 0:06:23.240 your imagination is yea. So there are a number of 0:06:23.240 --> 0:06:26.520 factors involved here. So in Chinese traditional medicine, it's known 0:06:26.600 --> 0:06:30.200 as MA. And I want to clarify, I want to 0:06:30.240 --> 0:06:34.160 remind everyone here that my Mandarin is horrible. So MA 0:06:35.040 --> 0:06:38.200 can depending on how you pronounced pronounced that m A 0:06:38.880 --> 0:06:42.840 H in the in English, you can mean horse, you 0:06:42.880 --> 0:06:46.560 can mean marijuana, you can mean mother. Um. But this 0:06:46.640 --> 0:06:49.480 is the form that refers to cannabis uh and it 0:06:49.520 --> 0:06:53.960 was used to treat absences of yin such as female 0:06:54.000 --> 0:07:00.159 weakness or menstruation, gout, rheumatism, malaria, berry berry constipation, and 0:07:00.360 --> 0:07:04.880 absolute mindedness. That last one is interesting, especially given what 0:07:04.920 --> 0:07:11.440 we talked about absolutely minded um. Also you see in 0:07:11.520 --> 0:07:14.840 traditional Indian medicine you see marijuana use for its sedative 0:07:15.600 --> 0:07:20.760 relaxing uh uh anti anxiety, anti convulsant actions as well 0:07:20.800 --> 0:07:27.000 as UH for analgesy appetite stimulation, and also to prevent 0:07:27.120 --> 0:07:30.720 and reduce fevers as well as anti bacterial effects as well. 0:07:30.800 --> 0:07:34.480 So again, as we've been saying, it has been used 0:07:34.520 --> 0:07:38.440 for a very long time for medicinal purposes. Yeah. Well, 0:07:38.720 --> 0:07:40.840 like like we've been saying, you know, we've known about 0:07:40.840 --> 0:07:42.480 it for such a long time. But here in the US, 0:07:42.600 --> 0:07:46.400 we only have one federal farm. Uh it's at the 0:07:46.480 --> 0:07:49.720 University of Mississippi. I don't know why they're but uh, 0:07:50.240 --> 0:07:52.320 that's where a lot of the testing has done in 0:07:52.760 --> 0:07:57.200 this particular you know clinic I guess has received millions 0:07:57.240 --> 0:08:00.760 of dollars in grant funding to track at lessons over 0:08:00.840 --> 0:08:02.920 ten years and to see what the effects of pot, 0:08:02.960 --> 0:08:06.280 alcohol and other drugs are on them. But that's really like, 0:08:07.080 --> 0:08:09.360 you know, like I mentioned in the last episode, like 0:08:09.400 --> 0:08:13.640 there are other researchers like that that guy, uh who 0:08:13.800 --> 0:08:16.240 is like collecting the DNA, But like I said, like 0:08:16.320 --> 0:08:18.760 he can't collect the marijuana and bring it back. He 0:08:18.800 --> 0:08:21.520 has to get the DNA on site and then bring 0:08:21.560 --> 0:08:24.880 the DNA with him back to his lab because transporting 0:08:24.880 --> 0:08:28.160 it would be illegal except for at this one place 0:08:28.160 --> 0:08:31.480 at the University of Mississippi. And and those properties that 0:08:31.560 --> 0:08:35.640 Robert just you know, had mentioned earlier, those are the 0:08:35.760 --> 0:08:39.480 medically beneficial properties that we're looking at today. To right, 0:08:39.600 --> 0:08:42.719 It's like it's like this thing that we knew and 0:08:42.880 --> 0:08:46.600 somehow forgot and are now rediscovering. That's what we're we're 0:08:46.640 --> 0:08:51.800 waiving the scientific magical whip at, right and to learn 0:08:51.800 --> 0:08:56.040 the properties. Uh. And you know, they're largely the therapeutic 0:08:56.160 --> 0:08:59.880 benefits are largely attributed to what are called plant or 0:09:00.000 --> 0:09:07.160 thrived turpo phenolic compounds called phyto cannabinoids. Uh. And the 0:09:07.240 --> 0:09:10.240 human body, like we talked about last episode, uses the 0:09:10.400 --> 0:09:17.360 endocannabinoids to modulate physiological processing like our appetite, pain, sensation, mood, memory, inflammation, 0:09:17.440 --> 0:09:21.520 insulin sensitivity, and fat and energy metabolism. Right. So there's 0:09:21.520 --> 0:09:24.480 a lot going on there. It's a very complicated system 0:09:24.520 --> 0:09:28.439 within our brains. UH. So you know, how can we 0:09:28.640 --> 0:09:33.040 use cannabis in order to sort of manipulate speed up 0:09:33.120 --> 0:09:36.920 or slow down or expand those processes, uh for our 0:09:36.960 --> 0:09:42.000 own benefit when we're sick? Essentially, one way has been 0:09:42.040 --> 0:09:46.320 to develop synthetic cannabinoids uh. And by developing those that 0:09:46.400 --> 0:09:49.760 helps us understand the biology of what's going on here, 0:09:49.840 --> 0:09:53.840 especially when it comes to pain management, inflammation, cancer, and 0:09:53.920 --> 0:09:59.040 neuro degenerative diseases. Yeah, and ultimately the creation of synthetic 0:09:59.360 --> 0:10:04.760 cannabinoi medications, medications that are based on cannabis. But they're like, 0:10:04.800 --> 0:10:07.440 that's a whole then you get additional problems to come in. Right. 0:10:07.520 --> 0:10:10.880 They're concerned sometimes about effect the effectiveness of it, as 0:10:10.920 --> 0:10:14.880 well as the costs involved because you know, not to 0:10:15.000 --> 0:10:19.520 play too much into the whole sort of natural cannabas 0:10:19.600 --> 0:10:22.439 versus big pharma thing. But yeah, and this it's hard 0:10:22.480 --> 0:10:24.360 to ignore the fact that on the surface of it, 0:10:24.880 --> 0:10:26.800 you have a plant that grows in the ground versus 0:10:26.880 --> 0:10:30.360 a pill that has manufactured and patented and sold. Yeah, 0:10:30.440 --> 0:10:32.880 and it's important that we distinguished that there those there 0:10:32.880 --> 0:10:37.800 are two different ways of medical application here. Right. So 0:10:37.840 --> 0:10:42.920 there's the quote unquote medical marijuana, and that's just actually 0:10:43.040 --> 0:10:46.880 the plant material or an extract from it that's derived 0:10:46.880 --> 0:10:50.320 from different strains that are reported to have medicinal properties. 0:10:50.880 --> 0:10:53.240 And you have to have a prescription from a state 0:10:53.320 --> 0:10:57.559 licensed physician for this. And keep in mind, this is 0:10:57.600 --> 0:10:59.520 the important thing. This is the distinction that a lot 0:10:59.559 --> 0:11:02.760 of doctor is make there's no human clinical testing on 0:11:02.880 --> 0:11:06.480 medical marijuana, right, so you're just kind of trusting the 0:11:06.559 --> 0:11:09.280 dispensary that you're getting the particular strain that's going to 0:11:09.320 --> 0:11:11.680 address whatever issue you have. Yeah, it is a Schedule 0:11:11.760 --> 0:11:15.840 one narcotic in the States. Um So, like cocaine is 0:11:15.880 --> 0:11:19.520 more legal than marijuana for anyone not familiar with that, 0:11:19.559 --> 0:11:23.800 because cocaine technically has medical benefits that marijuana does not. 0:11:25.000 --> 0:11:27.480 The second way though, is what we're talking about, the 0:11:27.520 --> 0:11:31.400 synthetic thing. That's the biopharmaceutical companies where they develop a 0:11:31.440 --> 0:11:37.240 cannabis derived drug using conventional US FDA regulatory pathways. So 0:11:37.360 --> 0:11:39.480 an example of this would be there's a company called 0:11:39.559 --> 0:11:43.200 GW Pharma in the UK and they've developed a product 0:11:43.280 --> 0:11:48.280 called stivx uh and that's for cancer related pain and 0:11:48.600 --> 0:11:54.280 for multiple sclerosis spasticity. But this drug costs reportedly around 0:11:54.440 --> 0:11:58.640 sixteen thousand U S. Dollars per patient to use. Uh. 0:11:58.840 --> 0:12:01.400 So you know those are the pros and cons there, right. 0:12:01.440 --> 0:12:04.880 The physicians approved that because it's been run through human trials, 0:12:05.160 --> 0:12:09.000 but super expensive, whereas the medical marijuana hasn't been run 0:12:09.120 --> 0:12:12.520 through trials, but it's relatively I mean I don't know 0:12:12.800 --> 0:12:16.040 how I wouldn't say that it's inexpensive, but right, like, 0:12:16.160 --> 0:12:20.920 it's not sixteen thousand dollars per instance. So okay, regardless 0:12:21.000 --> 0:12:23.720 of if if it's synthetic or medical marijuana, here's how 0:12:23.760 --> 0:12:26.160 we think it's working. Remember what we talked about in 0:12:26.200 --> 0:12:28.679 the last episode about the end of cannabinoid system and 0:12:28.720 --> 0:12:33.120 the brain processes. It's thought that the cannabinoids that are 0:12:33.360 --> 0:12:38.240 in cannabis interact with two protein receptors through our body, 0:12:38.480 --> 0:12:41.320 the CB one and the CB two. Now, the CB 0:12:41.480 --> 0:12:45.120 one receptors, these are most prevalent neurotransmitters that are in 0:12:45.200 --> 0:12:49.120 our brains and nerve systems. Nervous systems. They're found in 0:12:49.160 --> 0:12:52.559 our basil ganglia, in our hippocampus and the cerebellum. We 0:12:52.800 --> 0:12:56.840 think they're involved in affecting our appetite, mood, motor function, 0:12:57.000 --> 0:13:01.920 and neurocognition. The CB two recepts are almost exclusively in 0:13:02.000 --> 0:13:05.120 our immune system. Now that's really interesting, right You don't 0:13:05.200 --> 0:13:07.040 think about that when you when you think about like 0:13:07.200 --> 0:13:10.839 smoking pot like as as a like being beneficial or 0:13:11.120 --> 0:13:13.400 or or even adverse to your immune system. All that 0:13:13.440 --> 0:13:16.520 stuff we talked about in the last episode, but yeah, 0:13:16.720 --> 0:13:18.959 so that's where the CB two ones are. They mainly 0:13:19.040 --> 0:13:22.840 appear in tissue where there is cellular pathology, and these 0:13:22.880 --> 0:13:27.760 seem to be responsible for anti inflammatory and analgesic effects, 0:13:29.400 --> 0:13:31.960 and so in some of that we're getting into pain management. 0:13:32.040 --> 0:13:37.920 We're also even getting into potential cancer fighting properties as well. Yeah. Absolutely, 0:13:38.640 --> 0:13:41.880 Uh So we've been using these in clinical settings for 0:13:41.920 --> 0:13:46.480 a while now. Uh we use them for pain, for cancer, 0:13:46.520 --> 0:13:49.640 for multiple sclerosis. Like we talked about, the problem here 0:13:49.880 --> 0:13:51.720 is very similar to the problem that we talked about 0:13:51.760 --> 0:13:54.240 with m D m A and those previous episodes. The 0:13:54.320 --> 0:13:58.280 psychoactive properties that go along with the th HC, Right, 0:13:58.880 --> 0:14:02.319 So it's got a concentration that's based on whatever the 0:14:02.400 --> 0:14:07.439 plant variety, the preparation. So pure th h C can 0:14:07.480 --> 0:14:11.560 be derived naturally or produced synthetically, like like we talked 0:14:11.559 --> 0:14:15.520 about now. On its own. Th HC also has anti 0:14:15.640 --> 0:14:20.800 inflammatory and anti emetic properties, but it's development is hindered 0:14:21.040 --> 0:14:24.680 by psychotropic effects. Right. You can't have one without the other, right, 0:14:24.680 --> 0:14:27.960 And so you're talking about potentially high doses to treat something. 0:14:28.400 --> 0:14:31.960 But then the person may just set there string at 0:14:31.960 --> 0:14:34.600 the wall thinking about death, and you know it might 0:14:34.640 --> 0:14:39.000 be just the psycho tropic properties would just be too hot, right, 0:14:39.160 --> 0:14:42.400 And and in some cases th HC drugs have received 0:14:42.520 --> 0:14:47.120 FDA approval for instance, like as appetite stimulants for chemotherapy 0:14:47.160 --> 0:14:50.600 patients or or or to reduce nausea and vomiting. But yeah, 0:14:50.680 --> 0:14:53.400 you've also you've got that side effect there, um and 0:14:53.600 --> 0:14:57.560 and you know some people don't want that. Uh. The 0:14:57.600 --> 0:15:00.760 other problem is, like I mentioned a previous slee th 0:15:01.040 --> 0:15:06.040 HC tolerance develops in people after a certain chronic usage. 0:15:06.160 --> 0:15:10.760 So uh, it limits the clinical applications of it being 0:15:10.920 --> 0:15:13.720 used as a medicine for those things I mentioned, the 0:15:13.840 --> 0:15:17.960 cancer and MS because after a while it stops working. Yeah. Now, 0:15:18.120 --> 0:15:21.760 th h c V is one of the particular kinds 0:15:21.800 --> 0:15:27.280 of cannabinoids that's an abundant, non psychoactive phyto cannabinoid that's 0:15:27.360 --> 0:15:31.720 in cannabis, and the studies show that this particular chemical 0:15:32.240 --> 0:15:36.280 has anti convulsive effects in animals, so they thought that 0:15:36.360 --> 0:15:39.080 it can be used for epilepsy. And then we have CBD, 0:15:39.280 --> 0:15:42.720 which is a non psychotropic cannabinoid in cannabis, and it 0:15:42.800 --> 0:15:48.840 can be anti epileptic, anti inflammatory, anti emetic, muscle relaxing, 0:15:49.480 --> 0:15:56.040 neuroprotective and antipsychotic. It's been evaluated for treating epilepsy in schizophrenia, 0:15:56.440 --> 0:16:00.240 and CBD V is an omalogue of CBD and is 0:16:00.280 --> 0:16:03.360 being developed to treat appolute epilepsy as well. Yeah, and 0:16:03.440 --> 0:16:07.240 c b D has also shown promise in limiting neurological 0:16:07.360 --> 0:16:11.760 damage in Alzheimer's and Parkinson's patients, as well as people 0:16:11.800 --> 0:16:14.640 who just have suffered strokes or particular kinds of head trauma. 0:16:14.880 --> 0:16:17.080 One of the things that's really interesting about this to 0:16:17.240 --> 0:16:20.840 me is, as we discussed last episode, an adverse effect 0:16:20.960 --> 0:16:26.320 is if you're genetically predisposed to schizophrenia, chronic marijuana use 0:16:26.400 --> 0:16:28.960 has been shown to make it more likely that you 0:16:28.960 --> 0:16:32.520 will develop schizophrenia to sort of kick things off, serve 0:16:32.600 --> 0:16:35.680 as a precursor. Yeah, but at the same time, here's 0:16:35.680 --> 0:16:39.000 a chemical within cannabis that could be potentially used to 0:16:39.200 --> 0:16:42.240 treat schizophrenia. So it's all about really just kind of 0:16:42.400 --> 0:16:45.520 understanding how these things inter react with one another and 0:16:45.720 --> 0:16:49.840 determining like what is the appropriate UH dosage per individual, 0:16:50.120 --> 0:16:52.640 per conditions. It kind of comes back to the memory thing, 0:16:52.760 --> 0:16:55.240 the idea that it could be used both you know, 0:16:55.520 --> 0:16:58.720 it could be used inappropriately and make you focus too 0:16:58.840 --> 0:17:00.960 much on a negative memory. Work can be potentially be 0:17:01.080 --> 0:17:04.600 used to treat post traumatic stress disorders in which you 0:17:04.760 --> 0:17:08.360 have to sort of the associate the negative memories surrounding 0:17:08.720 --> 0:17:13.000 you know, particular triggers. Yeah. They're calling it memory extinction. Yeah, yeah, 0:17:13.160 --> 0:17:15.480 I mean that's powerful stuff. But right, like, it's two 0:17:15.520 --> 0:17:19.240 sides of the same coin. Memory extinction also a good 0:17:19.359 --> 0:17:24.600 name for a brand of frustrain of recreational marijuana. I 0:17:24.640 --> 0:17:30.520 wouldn't be surprised if somewhere and um and then there's 0:17:30.560 --> 0:17:34.200 also a c b G which is also reported to 0:17:34.520 --> 0:17:40.800 relieve intraocular pressure and has anti inflammatory properties. There's a 0:17:40.840 --> 0:17:43.359 lot of this. Where's the anti inflammatory thing? It's like 0:17:43.480 --> 0:17:46.120 it sounds like, you know, instead of taking an ivy 0:17:46.160 --> 0:17:49.359 profen or something like that, maybe this would work. But 0:17:49.520 --> 0:17:52.919 you know, the ivy prof and has its own adverse effects. Uh, 0:17:53.560 --> 0:17:55.240 there's a given take. You know, you've got to sort 0:17:55.240 --> 0:17:57.640 of be aware of like what each thing is doing 0:17:57.720 --> 0:18:02.120 to you. Um And that CBG one is being evaluated 0:18:02.200 --> 0:18:07.960 for multiple sclerosis in inflammatory bowel disease. Now, in clinical usage, 0:18:08.800 --> 0:18:13.400 cannabis is largely being used to help chronic non cancer 0:18:13.520 --> 0:18:18.600 pain and neurological diseases like MS and epilepsy. But it 0:18:18.880 --> 0:18:22.359 is also being used in oncology because it's helpful with 0:18:22.520 --> 0:18:25.800 chemotherapy like I mentioned earlier, with the nausea and the 0:18:25.880 --> 0:18:28.680 vomiting side effects as that, as well as it's a 0:18:28.880 --> 0:18:32.760 pain killer. Yeah, and uh and and also individable chemotherapy. 0:18:33.240 --> 0:18:36.919 Undergoing chemotherapy for a number of reasons. They um, they 0:18:37.160 --> 0:18:41.119 are suffering from decreased appetite in many situations, and this 0:18:41.320 --> 0:18:43.639 can be a way to stimulate the appetite and get 0:18:43.680 --> 0:18:48.199 the individual motivated to to eat the food they need 0:18:48.280 --> 0:18:50.920 to eat, right, Like where we whereas we joke about 0:18:50.960 --> 0:18:52.920 like the mun cheese or something like that, and like 0:18:53.119 --> 0:18:56.720 oh whatever, like whatever silly joke about, like when I 0:18:56.880 --> 0:18:59.600 have twelve pizzas or something like that after smoke weed, 0:18:59.720 --> 0:19:03.040 Like that's something that can really help people who are 0:19:03.080 --> 0:19:05.119 having a hard time keeping their food down. Yeah, I 0:19:05.160 --> 0:19:07.480 mean I always go back to uh, what was it 0:19:07.560 --> 0:19:09.240 it was called? It came from Hollywood. It was a 0:19:09.320 --> 0:19:11.840 fabulous film that came out when I was a kid 0:19:12.640 --> 0:19:16.200 that had these various comedians like Gilda Radner, Dan Ackroyd, 0:19:16.440 --> 0:19:19.480 John Candy, but also Cheach and Chong doing these bits 0:19:19.480 --> 0:19:23.200 about old old sci fi and horror movies. And so 0:19:23.440 --> 0:19:25.359 there is a segment where Cheech and Chong are going 0:19:25.400 --> 0:19:27.680 into the movie theater and I couldn't begin to understand 0:19:27.680 --> 0:19:30.680 any of these references at the time. But Cheech just 0:19:30.800 --> 0:19:34.680 gets a normal popcorn. But Chong he smoked up before 0:19:34.720 --> 0:19:36.560 he went in, so he has the munchies, and he 0:19:36.640 --> 0:19:38.679 ends up coming into the theater with a garbage can 0:19:38.840 --> 0:19:41.000 full of popcorn because he kept saying, is there bigger size? 0:19:41.040 --> 0:19:43.359 Is they're bigger sized? Eventually, just give him a trash 0:19:43.480 --> 0:19:46.600 can full of popcorn. Uh, And that's like our comic 0:19:47.160 --> 0:19:50.360 version of the Munchies. But this is a very real 0:19:50.440 --> 0:19:54.400 effect of cannabis consumption and one that we can utilize 0:19:54.840 --> 0:19:58.240 to to help patients who need their their their appetit 0:19:58.359 --> 0:20:00.600 and courage. Yeah. Absolutely, I think it's something that we 0:20:01.280 --> 0:20:04.040 often forget, is that there are some conditions that make 0:20:04.119 --> 0:20:07.720 it hard to eat. So when we're talking about this effect, 0:20:07.760 --> 0:20:09.879 when we're talking about the munchies, for for lack of 0:20:09.960 --> 0:20:14.160 a better word, um, it's all tying into canniboid receptor 0:20:14.400 --> 0:20:18.359 one CD one R and researchers have long recognized that 0:20:18.960 --> 0:20:21.080 that that this, uh, this is the receptor you can 0:20:21.119 --> 0:20:25.119 contribute to overeating. And there's actually a recent study came 0:20:25.160 --> 0:20:28.560 on the past past year from the Yale School of 0:20:28.640 --> 0:20:31.200 Medicine and it shed a lot of light on the 0:20:31.240 --> 0:20:35.480 particulars of what's going on. So by manipulating the cellular 0:20:35.600 --> 0:20:41.760 pathway that mediates marijuana's actions in the brains of transgenic mice, 0:20:42.320 --> 0:20:44.840 they observed the key role played by a group of 0:20:44.960 --> 0:20:50.639 nerve cells called pro opio melano cortine or p O 0:20:50.800 --> 0:20:54.879 mc neurons. Now, normally these are considered key drivers in 0:20:55.000 --> 0:20:59.600 reducing eating when we're full. So you smoke a normal 0:20:59.680 --> 0:21:02.560 to bo of cigarette and the nicotine makes p O 0:21:02.720 --> 0:21:07.480 mc neurons more active, curbing hunger. And yet the th 0:21:07.720 --> 0:21:11.639 HC actually reduces hunger hunger by activating these same p 0:21:11.800 --> 0:21:14.800 O mc neurons. So that's right, the same mechanism that 0:21:14.880 --> 0:21:18.600 normally turns the hot doughnuts sign off in your in 0:21:18.680 --> 0:21:21.240 your brain, th HC turns it on. And that's the 0:21:21.280 --> 0:21:25.560 fact that actually surprised the Yale researchers. Uh, there's still 0:21:25.560 --> 0:21:26.879 a lot of work that needs to be done to 0:21:26.960 --> 0:21:29.399 validate these findings and figuring that figure out exactly what 0:21:29.480 --> 0:21:32.600 they mean, but scientists hope that increased understanding of th 0:21:32.760 --> 0:21:36.040 hd s effect on appetite will enable the development of 0:21:36.160 --> 0:21:40.920 better appetite manipulators, both for weight loss as well as 0:21:41.560 --> 0:21:47.240 encouraging appetite and individuals undergoing chemotherapy treatment. UH. And so 0:21:47.960 --> 0:21:52.080 connecting back to oncology and its used as there, there's 0:21:52.160 --> 0:21:55.760 growing evidence that can of benoids on their own have 0:21:56.000 --> 0:21:59.840 anti tumor and cancer fighting effects. UH. And the re 0:22:00.040 --> 0:22:03.120 and why is it's thought that they suppress proliferative cell 0:22:03.280 --> 0:22:09.600 signaling pathways. They also inhibit blood vessel formation and encourage apoptosis, 0:22:09.680 --> 0:22:12.320 which is programmed cell death. And you may remember us 0:22:12.400 --> 0:22:14.600 talking about that in the m d M A episode 0:22:14.640 --> 0:22:17.119 because m d M A does the same thing. So 0:22:17.240 --> 0:22:20.679 the idea there is basically that it would encourage killing 0:22:20.880 --> 0:22:25.440 these malignant cells in your body. Um. And partly this 0:22:25.720 --> 0:22:30.480 is because remember that endo cannabinoid system in our brains, 0:22:31.359 --> 0:22:33.600 it plays a role in the life and death of 0:22:33.720 --> 0:22:38.119 individual cells in our bodies. So that seems like a 0:22:38.359 --> 0:22:41.440 very promising avenue of research to go down. Indeed, I 0:22:41.520 --> 0:22:45.399 mean this is this is an area where it definitely 0:22:45.480 --> 0:22:48.520 reminds me of running across statements online in the past 0:22:48.680 --> 0:22:53.119 where individuals have said marijuana cures cancer, and that is 0:22:53.160 --> 0:22:56.520 when it is outlawed because the government and big pharma 0:22:56.640 --> 0:22:59.280 do not want you to have the cure for cancer 0:22:59.320 --> 0:23:01.760 because they want to sell the treatment for cancer. That 0:23:01.920 --> 0:23:05.800 of course, is that is an over the gross simplification. 0:23:06.080 --> 0:23:09.960 Simplification that would make sense and maybe an alternate version 0:23:10.000 --> 0:23:12.879 of reality, but not in our our real world played 0:23:12.920 --> 0:23:17.320 by wicked problems. Um but but still you see shades 0:23:17.359 --> 0:23:22.040 of that that scenario in the reality of the situation. Yeah, absolutely, 0:23:22.160 --> 0:23:24.840 I mean, like uh so, to drill down a little 0:23:24.880 --> 0:23:27.159 further into the science of it, those CB one and 0:23:27.280 --> 0:23:30.359 CB two receptors we mentioned earlier, those are found in 0:23:30.480 --> 0:23:34.600 higher concentrations in tumor cells, specifically the ones that are 0:23:34.600 --> 0:23:38.359 surrounding normal tissue in a whole variety of cancers. So 0:23:38.600 --> 0:23:44.440 cannabinoids may also inhibit tumor cell growth while sparing normal tissue. 0:23:44.760 --> 0:23:47.760 So this is something you know, along with the m 0:23:47.840 --> 0:23:51.800 d M, a research that is well worth pursuing. And 0:23:52.160 --> 0:23:53.919 like I mentioned at the top, we've only got one 0:23:53.960 --> 0:23:55.920 place in the whole United States where we can do 0:23:56.080 --> 0:23:58.840 this kind thing. But you know, mid to late clinical 0:23:58.920 --> 0:24:01.920 trials are underway to see if it can be used 0:24:02.000 --> 0:24:05.680 therapeutically both in oncology, but also with things like hunting 0:24:05.760 --> 0:24:10.040 Vin's disease, ultrative colitis, Crohn's disease, and you know, as 0:24:10.080 --> 0:24:12.920 I mentioned, schizophrenia. So some of these same properties that 0:24:13.080 --> 0:24:19.680 make cannabis a promising treatment for UM for individuals undergoing chemotherapy, 0:24:20.160 --> 0:24:23.520 it also makes it a promising treatment for individuals who 0:24:23.520 --> 0:24:26.399 are undergoing treatment for HIV and AIDS. Specifically when you're 0:24:26.400 --> 0:24:30.320 getting into things like appetite loss, uh and UH as well, 0:24:31.040 --> 0:24:33.240 you know, we we've discussed it, it's an effect on 0:24:33.320 --> 0:24:36.439 the immune system, and since certainly, uh, the immune system 0:24:36.600 --> 0:24:39.919 is is a is a vital area of consideration when 0:24:40.000 --> 0:24:43.520