WEBVTT - Where’s my eternal youth? Part 1

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<v Speaker 1>Welcome to Stuff to Blow Your Mind from how Stuff

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<v Speaker 1>Works dot com. Hey are you welcome to Stuff to

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<v Speaker 1>Blow your Mind? My name is Robert Lamb and I'm

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<v Speaker 1>Joe McCormick and Robert I want to ask you about

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<v Speaker 1>a Greek myth, you know, the myth of tiffan Us.

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<v Speaker 1>This is not one that I am am readily familiar

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<v Speaker 1>with off the tof of my head. Well, it's one

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<v Speaker 1>of those great ones with doomed lovers. Doomed lovers just fantastic. Yeah,

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<v Speaker 1>is there does a god show up and act particularly

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<v Speaker 1>crappy towards mortals? Uh not. I don't know if it's

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<v Speaker 1>on purpose. You do get Zeus being a jerk, but

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<v Speaker 1>it might be like he's a jerk by accident, or

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<v Speaker 1>maybe he's a jerk on purpose. It's kind of hard

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<v Speaker 1>to tell because being a jerk is kind of Zeus

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<v Speaker 1>is default thing in general. Yeah, Zeus in this myth

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<v Speaker 1>acts kind of like the Monkeys Paul and the classic

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<v Speaker 1>short story where you get the wish but not quite

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<v Speaker 1>in the way you wanted it. So here's how it goes.

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<v Speaker 1>And this is the version that's in the Homeric Hymn

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<v Speaker 1>to Aphrodite So the myth involves the goddess aos Aus

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<v Speaker 1>is the goddess of Dawn, and she falls in love

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<v Speaker 1>with a mortal man from Troy named Tiffanus. And this

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<v Speaker 1>is horrible, right, It's horrible for a goddess to fall

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<v Speaker 1>in love with a mortal because while the gods may

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<v Speaker 1>live eternally, dining on the ambrosia and just going on

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<v Speaker 1>into the future, of course, mortal people, as the name implies,

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<v Speaker 1>will die. And she hates this idea. She hates the

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<v Speaker 1>idea that the man she's fallen in love with will

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<v Speaker 1>someday die while she gets to go on living forever.

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<v Speaker 1>She can't bear the thought of it. So she goes

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<v Speaker 1>to Zeus and she makes a request, well you grant

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<v Speaker 1>my lover, Tiffannus, eternal life, and Zeus does it. Usually,

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<v Speaker 1>you know, usually Zeus is a jerk, but here he's like, yes, yes,

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<v Speaker 1>I will do that for you. Aos. Well, maybe he

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<v Speaker 1>was busy and he's just like, okay, yeah, I'll just

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<v Speaker 1>go ahead and check this off the list because I've

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<v Speaker 1>I've got this, uh, this other torment in mind for

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<v Speaker 1>another mortal, right, don't have time to be a jerk.

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<v Speaker 1>Just bam eternal life, you will not perish and die

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<v Speaker 1>like the other mortals. But then it takes a dark turn.

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<v Speaker 1>So let me read from the translation of the home

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<v Speaker 1>Eric him to Aphrodite, And this is translated by Hugh

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<v Speaker 1>Evelyn White quote. So also golden throned Aos wrapped away

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<v Speaker 1>tithan Us, who was of your race and like the

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<v Speaker 1>deathless gods. And she went to ask the dark clouded

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<v Speaker 1>son of Chronos that he should be deathless and live eternally.

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<v Speaker 1>And Zeus bowed his head to her prayer and fulfilled

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<v Speaker 1>her desire. Okay, so he's granting the wish. Too simple,

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<v Speaker 1>was queenly Aos. She thought not in her heart to

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<v Speaker 1>ask youth for him and to strip him of the

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<v Speaker 1>slough of deadly age. So while he enjoyed the sweet

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<v Speaker 1>flower of life, he lived rapturously with golden throned Aos,

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<v Speaker 1>that early born by the streams of ocean at the

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<v Speaker 1>ends of the earth. But when the first gray hairs

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<v Speaker 1>began to ripple from his comely head and noble chin,

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<v Speaker 1>queenly Aos kept away from his bed, though she cherished

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<v Speaker 1>him in her house and nourished him with food and ambrosia,

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<v Speaker 1>and gave him rich clothing, but when loathsome old age

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<v Speaker 1>pressed full upon him, and he could not move nor

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<v Speaker 1>lift his limbs. This seemed to her in her heart

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<v Speaker 1>the best counsel. She laid him in a room and

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<v Speaker 1>put to the shining doors. There he babbles endlessly, and

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<v Speaker 1>no more has strength at all such as once he

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<v Speaker 1>had in his supple limbs. M Okay, well, this makes

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<v Speaker 1>me think Zeus probably just agreed to her request because

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<v Speaker 1>all the gods know that mortals are going to ask

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<v Speaker 1>for immortality at some point or the other, and it's

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<v Speaker 1>probably not going to phrase the question properly, and you

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<v Speaker 1>should let them have it because it will teach them

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<v Speaker 1>a lesson. Well, yeah, he'll learn when he's old and

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<v Speaker 1>babbling and decrepit but cannot die. Because global myth cycles

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<v Speaker 1>are filled with stories of of immortality gone wrong. You know,

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<v Speaker 1>it's either a wandering immortal who's doomed or or lovers

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<v Speaker 1>who you know, obtain a portion of immortality and it's mishandled.

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<v Speaker 1>There's a there's a wonderful example of this in the

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<v Speaker 1>in Chinese myth with the the Elixir of Immortality and

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<v Speaker 1>the and the Woman of the Moon. Oh does it

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<v Speaker 1>come back to bite her or come back to bite

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<v Speaker 1>the person who wants it um it gets. There are

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<v Speaker 1>a few different versions of the tale, but essentially, you know,

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<v Speaker 1>one person is immortal and the other is not. That

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<v Speaker 1>sort of thing this this this mismatch that we see

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<v Speaker 1>president in the Greek tale as well. Man, why are

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<v Speaker 1>there so many myths and folk tales where people get

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<v Speaker 1>punished for wanting better than their lot in life? Well,

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<v Speaker 1>because you can't have it, I mean, especially when it

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<v Speaker 1>comes to things like avoiding death and avoiding aging. You're

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<v Speaker 1>not gonna get it. So there's something refreshing about stories

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<v Speaker 1>in which people do get it, and it backfires because

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<v Speaker 1>that way we think, oh, well, this this thing that

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<v Speaker 1>I cannot have is actually not that great, So thank goodness,

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<v Speaker 1>I'm going to grow old and die. Yeah. I wonder

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<v Speaker 1>if it makes you feel like you're not so bad off.

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<v Speaker 1>It's like, well, I'm gonna die one day, but I

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<v Speaker 1>could be like Tiffanius and that's even worse. Exactly, So,

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<v Speaker 1>I think the myth is sort of an embodiment of

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<v Speaker 1>this cruel fact about human nature. It's not just that,

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<v Speaker 1>as they say in Bravos, all men must die, but

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<v Speaker 1>that all people must decline. I think Warren Zevon put

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<v Speaker 1>it best. He said time treats everybody like a fool.

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<v Speaker 1>And I think that's the case. And no amount of lawyers, guns,

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<v Speaker 1>or money will get you out of this, that's right.

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<v Speaker 1>So on one hand, you've got the idea of death.

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<v Speaker 1>And death is a sort of unavoidable fact about biology

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<v Speaker 1>because living organisms are these finely tuned factories of chemical reactions.

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<v Speaker 1>And if you make substantial changes to the factory, say

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<v Speaker 1>by jamming a rock through part of it, or biting

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<v Speaker 1>part of it off, or filling it up with parasites

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<v Speaker 1>that come up all the gears, the factory isn't gonna

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<v Speaker 1>work the same anymore. It might not work at all

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<v Speaker 1>were physical creatures were subject to physical disruption. So the

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<v Speaker 1>potential for death is unavoidable. It's sort of part of

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<v Speaker 1>what it means to be alive. But aging not quite

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<v Speaker 1>so much. This steady time correlated decline in our biological fitness.

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<v Speaker 1>Why does that have to happen? That's not physically inevitable

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<v Speaker 1>in the same way that death is. Yes, and this

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<v Speaker 1>is going to be the question we're gonna be discussing

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<v Speaker 1>in this pair of episodes. Now we do want to

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<v Speaker 1>drive home. We're not going to get as much into

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<v Speaker 1>some of the mechanics of aging, like we're not going

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<v Speaker 1>to get into telomeres and telomerase and all and all

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<v Speaker 1>of that, although that's a wonderfully insightful topic onto itself.

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<v Speaker 1>We're gonna be talking more about the these this sort

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<v Speaker 1>of evolutionary function of aging, if it has one, right,

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<v Speaker 1>aging is something that has such a cost for the

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<v Speaker 1>organisms that undergo it, like tiffanus. What pays for it biologically?

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<v Speaker 1>Why does it exist? Now? To underscore the fact that

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<v Speaker 1>aging is not necessarily something that is inevitable, and especially

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<v Speaker 1>not aging as early as we do, we should maybe

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<v Speaker 1>look at some organisms that do not age in the

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<v Speaker 1>same way we do. Yeah, they're there are a number

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<v Speaker 1>of organisms. I'm sure a number of them come to

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<v Speaker 1>to everyone's mind here. You think of ancient hoary tortoises

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<v Speaker 1>stumbling across the the ground, right, or perhaps your mind

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<v Speaker 1>turns to the greenland shark. Will come back to that

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<v Speaker 1>one in a second. But really one of the more

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<v Speaker 1>insightful examples here is the hydra, or at least individuals

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<v Speaker 1>in the hydra genus. So you're talking about the monster

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<v Speaker 1>that gets its head cut off and grows two more. No,

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<v Speaker 1>as much as I do love the mythical hydra, now

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<v Speaker 1>these are the natural world hydras, tiny tentacle creatures that

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<v Speaker 1>need to continue to wow scientists because they they have

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<v Speaker 1>a number of just wonderfully bizarre and monstrous capability. So

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<v Speaker 1>they can reproduce through a sexual butting. They have these

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<v Speaker 1>mouths that open up kind of like wounds in their

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<v Speaker 1>body and then close. There's some fabulous videos of them

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<v Speaker 1>doing that. It looks like you're staring into the mouth

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<v Speaker 1>of hell. And they have this seemingly natural inability to grow,

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<v Speaker 1>grow old, and die of natural causes. They boast low

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<v Speaker 1>mortality rates throughout their lives and apparently this is according

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<v Speaker 1>to one Dr Owen Jones from the University of Southern Denmark.

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<v Speaker 1>He has claimed that it would take four hundred years

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<v Speaker 1>for of a hydro population to die of natural causes

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<v Speaker 1>in the lab. Wow, well, well that's a hardy species. Yeah,

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<v Speaker 1>So let me let me back some of that up

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<v Speaker 1>here with with some more facts about the life of

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<v Speaker 1>the hydra. So their fertility rates remain constant their entire lives, which,

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<v Speaker 1>as will discuss, is is pretty unique and according to

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<v Speaker 1>um Pomona College biology researcher Professor Daniel Martinez. He has

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<v Speaker 1>repeatedly found no evidence of sinescence in laboratory caddled hydra. Yeah,

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<v Speaker 1>and he even goes so far as to state that

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<v Speaker 1>an individual hydra can live forever under the right laboratory circumstances. Well, now,

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<v Speaker 1>of course that's the catch, right. The hydra's natural environment

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<v Speaker 1>offers sufficient hostilities to make natural death by old age

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<v Speaker 1>and impossibility. You got disease, predators, water contamination. These are

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<v Speaker 1>the things that usually kill a hydra off in due time,

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<v Speaker 1>and likewise, scientists have yet to create a hydra utopia

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<v Speaker 1>that can sustain them indefinitely. Now, this is a good

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<v Speaker 1>point in the use of the word immortality, which sometimes

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<v Speaker 1>comes up when people are covering organisms like these. There

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<v Speaker 1>are a couple of different ways you could look at immortality.

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<v Speaker 1>One would be the Highlander version or something like that,

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<v Speaker 1>where there's just like nothing that can kill you except

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<v Speaker 1>maybe one or two little things, but that you are

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<v Speaker 1>generally invulnerable to death. And then there'd be a different

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<v Speaker 1>version of immortality that says, yeah, you're vulnerable to death

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<v Speaker 1>by injury or disease. You just don't naturally grow old

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<v Speaker 1>and die. You don't have a cap on your lifespan.

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<v Speaker 1>That would be more like, what are are the elves

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<v Speaker 1>of Middle Earth? Kind of like that, like they can

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<v Speaker 1>be killed in battle, but they don't grow old and die. Yeah. Well,

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<v Speaker 1>I mean I would argue that the immortals of Highlander

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<v Speaker 1>are much the same, Like there's a there's a very

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<v Speaker 1>specific thing you can do to kill them. Uh, and

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<v Speaker 1>technically anyone can do it. It's just you've got to

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<v Speaker 1>get the drop on them. Right. We should mention that

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<v Speaker 1>we're popping in little references to Highlander to get you

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<v Speaker 1>ready for the fact that one day soon we're going

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<v Speaker 1>to do a Science of Highlander two episode and I'm

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<v Speaker 1>not kidding. Yeah, you have advanced warnings so you can

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<v Speaker 1>all go review at least the first two films. Well,

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<v Speaker 1>I would say just the first two films actually, Okay,

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<v Speaker 1>But back to the hydra and biological immortality in the

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<v Speaker 1>real world. Yeah, so this is a major point really

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<v Speaker 1>for all organisms. The natural world is generally sufficient to

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<v Speaker 1>ensure mortality. It's dangerous, it's filled with competitors, predators, pathogens, accidents,

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<v Speaker 1>and all manner of additional hazards. Now, humans and their

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<v Speaker 1>captives tend to live in a very privileged space, largely

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<v Speaker 1>removed from the threat of predation. At least you'll find

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<v Speaker 1>other creatures with no natural predators as well. Typically these

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<v Speaker 1>are apex predators, but that doesn't mean they don't have

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<v Speaker 1>to deal with all these other dangers. Well. No, when

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<v Speaker 1>you think about an apex predator, just because there's nothing

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<v Speaker 1>that tackles it and tears it apart and eats it,

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<v Speaker 1>that doesn't mean that it's not subject to attacks from

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<v Speaker 1>its environment, right. I mean, it of course is subject

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<v Speaker 1>to disease. But one of the other things to think

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<v Speaker 1>about with an apex predator is these creatures are very

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<v Speaker 1>often constantly at the edge of starvation. And so when

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<v Speaker 1>you see the antelope running from the cheetah or something,

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<v Speaker 1>of course the cheetahs trying to kill the antelope, but

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<v Speaker 1>by escaping, the antelope is sort of also trying to

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<v Speaker 1>kill the cheetah. It is starving the cheetah to death

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<v Speaker 1>by a escaping. The cheat is a great example too,

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<v Speaker 1>because either cheetah injures itself in the pursuit of a prey,

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<v Speaker 1>especially if it tackles prey that is a little beyond

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<v Speaker 1>its ability or or is potentially beyond its ability. It

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<v Speaker 1>can sustain an injury that results in death, not because

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<v Speaker 1>it becomes infected or what have you, but because say,

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<v Speaker 1>a wounded limb on a cheetah can mean it cannot

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<v Speaker 1>pursue prey and it starves. Right, This is another thing

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<v Speaker 1>we often fail to appreciate in the natural world is

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<v Speaker 1>how how absolutely damning a small injury can be to

0:12:37.280 --> 0:12:40.840
<v Speaker 1>an organism that has to hunt or escape hunters to survive.

0:12:41.160 --> 0:12:44.680
<v Speaker 1>You also, of course have read about large cats that

0:12:44.720 --> 0:12:48.720
<v Speaker 1>have turned man killer and uh in some of these cases,

0:12:48.880 --> 0:12:51.920
<v Speaker 1>if remember correctly, sometimes it has to do with the

0:12:52.200 --> 0:12:55.440
<v Speaker 1>decline of dental health, like that their their inability to

0:12:55.480 --> 0:12:59.200
<v Speaker 1>depend on their their teeth for their traditional prey and

0:12:59.280 --> 0:13:02.800
<v Speaker 1>it leads to sort of a desperate switch in their

0:13:02.840 --> 0:13:07.079
<v Speaker 1>their selection of prey. So anyway, most most individuals are

0:13:07.080 --> 0:13:09.520
<v Speaker 1>going to die or be killed before they can grow old,

0:13:10.080 --> 0:13:12.480
<v Speaker 1>so there's already a low probability of being alive and

0:13:12.559 --> 0:13:16.320
<v Speaker 1>reproductive at an advanced stage. Still, hyders are are really

0:13:16.360 --> 0:13:17.719
<v Speaker 1>interesting because it give us a real world of the

0:13:17.760 --> 0:13:21.520
<v Speaker 1>world example of how how undying creatures would work on

0:13:21.520 --> 0:13:25.760
<v Speaker 1>a biological level. They're hardy, they're regenerative. They have they

0:13:25.760 --> 0:13:29.440
<v Speaker 1>have evolved to thrive in the harsh environments, and it

0:13:29.480 --> 0:13:32.839
<v Speaker 1>actually reminds me of an alien species that shows up

0:13:32.880 --> 0:13:35.640
<v Speaker 1>in an Ian em banks. The Culture series, of course,

0:13:35.679 --> 0:13:37.720
<v Speaker 1>go into the Culture Yeah, I mean he he always

0:13:37.720 --> 0:13:40.640
<v Speaker 1>managed to work so many wonderful scientific topics into his

0:13:40.640 --> 0:13:44.400
<v Speaker 1>his books, and one of these topics is biological immortality. Alright,

0:13:44.520 --> 0:13:47.240
<v Speaker 1>So we meet in the really the very first Culture book,

0:13:47.679 --> 0:13:51.720
<v Speaker 1>we meet the Dherens. And here's just a quick quote.

0:13:51.920 --> 0:13:54.640
<v Speaker 1>The Adherens themselves had evolved on their planet a deer

0:13:55.080 --> 0:13:58.439
<v Speaker 1>as the top monster from a whole planet full of monsters.

0:13:59.040 --> 0:14:02.800
<v Speaker 1>The frenetic and savage ecology of a deer in its

0:14:02.840 --> 0:14:05.720
<v Speaker 1>early days had long since disappeared, and so had all

0:14:05.800 --> 0:14:09.800
<v Speaker 1>the other homeworld monsters except those in zoos. But the

0:14:09.840 --> 0:14:13.600
<v Speaker 1>Adherens had retained the intelligence that made them winners, as

0:14:13.600 --> 0:14:17.559
<v Speaker 1>well as the biological immortality, which, due to the viciousness

0:14:17.559 --> 0:14:19.960
<v Speaker 1>of the fight for survival back then, not to mention,

0:14:20.000 --> 0:14:23.479
<v Speaker 1>a deer's high radiation levels had been an evolutionary advantage

0:14:23.560 --> 0:14:26.560
<v Speaker 1>rather than a recipe for stag nation. Now, I think

0:14:26.680 --> 0:14:29.200
<v Speaker 1>that might be something interesting to come back to maybe

0:14:29.200 --> 0:14:32.240
<v Speaker 1>in the second episode and consider whether it would actually

0:14:32.320 --> 0:14:36.480
<v Speaker 1>work that way and what the effect of high mortality

0:14:36.520 --> 0:14:39.560
<v Speaker 1>at different stages of life would have on the life

0:14:39.560 --> 0:14:42.200
<v Speaker 1>span of an organism. Alright, well, on that note, let's

0:14:42.240 --> 0:14:44.520
<v Speaker 1>take a quick break, and when we come back, we're

0:14:44.560 --> 0:14:47.760
<v Speaker 1>gonna roll through just a few other long living organisms,

0:14:48.160 --> 0:14:51.320
<v Speaker 1>uh that are not a hydra or an adheran. Thank

0:14:51.880 --> 0:14:56.880
<v Speaker 1>thank Alright, we're back. So I mentioned the greenland shark earlier.

0:14:57.520 --> 0:15:01.000
<v Speaker 1>This one is pretty impressive because greenland sharks live where

0:15:01.080 --> 0:15:05.400
<v Speaker 1>we understand now about four hundred years uh. And this

0:15:05.440 --> 0:15:08.520
<v Speaker 1>is an exclusively wild species as well. This is not

0:15:08.600 --> 0:15:11.920
<v Speaker 1>something you're gonna find growing old and fat in an aquarium.

0:15:12.000 --> 0:15:15.640
<v Speaker 1>These are sharks generally don't do very well in aquariums. Correct, yeahs,

0:15:15.720 --> 0:15:18.440
<v Speaker 1>And no one has a greenland shark that I am

0:15:18.520 --> 0:15:22.040
<v Speaker 1>aware of as of this recording. At two thousand sixteen,

0:15:22.400 --> 0:15:26.360
<v Speaker 1>University of Copenhagen study estimated that one female greenland shark

0:15:26.920 --> 0:15:29.120
<v Speaker 1>uh had it was it was at least four hundred

0:15:29.200 --> 0:15:31.960
<v Speaker 1>years old, and that the species doesn't even reach sexual

0:15:32.040 --> 0:15:35.480
<v Speaker 1>maturity until one d and fifty. So think of that,

0:15:36.520 --> 0:15:40.000
<v Speaker 1>not until they've reached an age that exceeds every human

0:15:40.040 --> 0:15:43.080
<v Speaker 1>being who has ever lived, and that's counting unverified but

0:15:43.200 --> 0:15:48.320
<v Speaker 1>not mythic individual humans, right, not the Highlanders or you know,

0:15:48.440 --> 0:15:52.680
<v Speaker 1>like you know, biblical days. Right. Yeah. Now, of course

0:15:52.880 --> 0:15:56.960
<v Speaker 1>that's still not the oldest animal because there was a

0:15:57.040 --> 0:16:00.920
<v Speaker 1>clam named me. Was this the first line of a

0:16:01.000 --> 0:16:03.520
<v Speaker 1>children's book? I know it should be, well, I would be.

0:16:03.520 --> 0:16:05.520
<v Speaker 1>I would actually be surprised if there's not a children's

0:16:05.520 --> 0:16:08.160
<v Speaker 1>book about Ming. There was a clam named Ming. Yeah,

0:16:08.200 --> 0:16:11.040
<v Speaker 1>and Ming did love to sing. Yeah. This here it

0:16:11.120 --> 0:16:15.840
<v Speaker 1>rights itself. So technically Ming was a qua hog clam.

0:16:15.840 --> 0:16:18.800
<v Speaker 1>This is um, an Arctic variety of clam, and it

0:16:18.840 --> 0:16:21.480
<v Speaker 1>was discovered off the coast of Iceland in two thousand

0:16:21.480 --> 0:16:24.120
<v Speaker 1>and six. Now, at the time they thought it was

0:16:24.200 --> 0:16:26.600
<v Speaker 1>around four hundred and five years old, so they named

0:16:26.640 --> 0:16:28.960
<v Speaker 1>it after the Ming dynasty that would have ruled China

0:16:29.160 --> 0:16:32.480
<v Speaker 1>at this time. Later estimates, and this is supported by

0:16:32.480 --> 0:16:35.640
<v Speaker 1>carbon dating, would boost that age to five hundred and

0:16:35.720 --> 0:16:39.360
<v Speaker 1>seven years half a millennium. So this means that the

0:16:39.640 --> 0:16:44.760
<v Speaker 1>creature was born in fourteen and that's still within the

0:16:44.840 --> 0:16:49.760
<v Speaker 1>Ming dynasty, which went to four And to throw another

0:16:49.840 --> 0:16:52.240
<v Speaker 1>point of context in there, this was around the time

0:16:52.280 --> 0:16:55.480
<v Speaker 1>that Leonardo da Vinci completed the Last Supper. It's the

0:16:55.560 --> 0:16:59.680
<v Speaker 1>year Portuguese explorer Vasco da Gama reached India. That's when

0:16:59.720 --> 0:17:02.400
<v Speaker 1>this this thing was was born and then it died.

0:17:02.400 --> 0:17:05.159
<v Speaker 1>In two thousand and six, there was a clam named Ming,

0:17:05.240 --> 0:17:09.679
<v Speaker 1>and Ming remembered everything. There you go now the plant

0:17:09.680 --> 0:17:12.440
<v Speaker 1>where the world of course has all of this beat. Uh.

0:17:12.480 --> 0:17:17.440
<v Speaker 1>There's the great Basin bristle cone Pine or Pinus long gava,

0:17:17.800 --> 0:17:20.400
<v Speaker 1>and it can only lived to over five thousand years

0:17:20.400 --> 0:17:22.200
<v Speaker 1>of age, and that takes us back to the very

0:17:22.320 --> 0:17:26.399
<v Speaker 1>end of the Neolithic period. Work on Stonehenge had begun.

0:17:26.480 --> 0:17:28.440
<v Speaker 1>This was the age of the Pharaoh, so it lived

0:17:28.480 --> 0:17:31.560
<v Speaker 1>through the rise and the fall of the Roman Empire. Now,

0:17:31.560 --> 0:17:35.080
<v Speaker 1>of course this highlights that different kinds of organisms have

0:17:35.400 --> 0:17:38.680
<v Speaker 1>massively different potential when it comes to life span. Yeah,

0:17:38.720 --> 0:17:41.040
<v Speaker 1>and of course plants are very different from animals. This

0:17:41.119 --> 0:17:42.880
<v Speaker 1>reminds me that one of the ideas that was brought

0:17:42.960 --> 0:17:45.880
<v Speaker 1>up recently. I believe on our discussion module on Facebook

0:17:46.000 --> 0:17:49.160
<v Speaker 1>or Facebook group, that we should do something just on plants,

0:17:49.200 --> 0:17:51.359
<v Speaker 1>like what is a plant? To sort of strip it

0:17:51.400 --> 0:17:53.439
<v Speaker 1>down to its basics. I kind of like that idea.

0:17:54.119 --> 0:17:58.720
<v Speaker 1>It's a really lazy animal. Well I've got a really

0:17:58.760 --> 0:18:02.240
<v Speaker 1>lazy one then for you here, Uh, there's at least

0:18:02.240 --> 0:18:06.560
<v Speaker 1>one step beyond the great base in Bristle Cone Pine.

0:18:06.800 --> 0:18:09.600
<v Speaker 1>And this is something you'll find in fish Lake National

0:18:09.680 --> 0:18:12.560
<v Speaker 1>Park in Utah here in the United States. Uh, the

0:18:12.640 --> 0:18:15.679
<v Speaker 1>quaking aspen tree, which is also the state tree by

0:18:15.720 --> 0:18:18.840
<v Speaker 1>the way, also known as the trembling Giant or pando,

0:18:18.960 --> 0:18:22.479
<v Speaker 1>which means I spread. So what we have here, and

0:18:22.480 --> 0:18:26.040
<v Speaker 1>this is this is one where not everybody necessarily agrees with.

0:18:26.880 --> 0:18:29.160
<v Speaker 1>This might be sort of bending the definition a little

0:18:29.160 --> 0:18:31.560
<v Speaker 1>bit of what is a long living organism. But what

0:18:31.600 --> 0:18:34.560
<v Speaker 1>we have here is a single clone of quaking aspen

0:18:34.640 --> 0:18:38.199
<v Speaker 1>connected by a single extensive roots system that's roughly the

0:18:38.240 --> 0:18:40.960
<v Speaker 1>size of Vatican City, a hundred and six acres, thirteen

0:18:41.000 --> 0:18:44.800
<v Speaker 1>million pounds, and it's all eighty thousand years old. So

0:18:44.840 --> 0:18:48.760
<v Speaker 1>what you're talking about is a forest that is all

0:18:49.080 --> 0:18:52.440
<v Speaker 1>sort of in some way the same organism, right, you could.

0:18:52.480 --> 0:18:55.119
<v Speaker 1>It's it's not as simple as the clam was born

0:18:55.640 --> 0:18:58.240
<v Speaker 1>in this century and it died in this one. But

0:18:58.400 --> 0:19:00.560
<v Speaker 1>if you if you've been the deaf Issian enough and

0:19:00.600 --> 0:19:03.280
<v Speaker 1>you accept this as an example, we're talking about a

0:19:03.400 --> 0:19:06.280
<v Speaker 1>thing that has lived since humans first left Africa to

0:19:06.359 --> 0:19:09.880
<v Speaker 1>colonized the world. Wow. Yeah, now, Robert, here's something I've

0:19:09.880 --> 0:19:14.680
<v Speaker 1>always wondered about dinosaurs. You got to wonder how long

0:19:14.720 --> 0:19:17.359
<v Speaker 1>they lived, especially because this gets warped by our sense

0:19:17.359 --> 0:19:21.119
<v Speaker 1>of history. I think, because they lived so long ago,

0:19:22.160 --> 0:19:25.280
<v Speaker 1>you just naturally go to this completely illogical place where

0:19:25.320 --> 0:19:29.560
<v Speaker 1>they must have lived a long time. Like, Okay, tyrannosaurs

0:19:29.600 --> 0:19:32.320
<v Speaker 1>Rex lived maybe three hundred years. I mean they got

0:19:32.320 --> 0:19:34.879
<v Speaker 1>they got very big, so you have to imagine it

0:19:34.920 --> 0:19:37.000
<v Speaker 1>took them a while to grow as big as they did.

0:19:37.400 --> 0:19:39.520
<v Speaker 1>This would take a lot of years of eating and

0:19:39.600 --> 0:19:42.919
<v Speaker 1>cell division and all that. So so so surely they

0:19:42.920 --> 0:19:46.040
<v Speaker 1>had very long lifespans. Well, this used to be the

0:19:46.320 --> 0:19:49.680
<v Speaker 1>main theory. And this was in part because of either

0:19:49.800 --> 0:19:52.200
<v Speaker 1>size or at least the size of many of the specimens,

0:19:52.320 --> 0:19:54.480
<v Speaker 1>and the fact that we thought, well, they were essentially

0:19:55.000 --> 0:19:58.720
<v Speaker 1>giant reptiles, and so based on slow reptile growth rates

0:19:58.720 --> 0:20:01.160
<v Speaker 1>and their size, they said, well, big dinos probably lived

0:20:01.320 --> 0:20:04.840
<v Speaker 1>several hundred years. But today paleontolo just believed they grew

0:20:05.160 --> 0:20:08.080
<v Speaker 1>more like birds and mammals, and this cuts back on

0:20:08.119 --> 0:20:12.240
<v Speaker 1>their lifespans somewhat. So for instance, the Field Museum of Chicago,

0:20:12.840 --> 0:20:15.840
<v Speaker 1>they have this, uh, this these t rex remains that

0:20:15.920 --> 0:20:18.960
<v Speaker 1>they named Sue. Sue. She is great. Yeah, she's a

0:20:18.960 --> 0:20:21.359
<v Speaker 1>wonderful specimen. You get to look right up at her

0:20:21.400 --> 0:20:24.719
<v Speaker 1>and get a sense of the true size of this,

0:20:24.720 --> 0:20:27.919
<v Speaker 1>this amazing species. Can I say something embarrassing? Go for it.

0:20:27.960 --> 0:20:30.399
<v Speaker 1>I cried a little bit at Sue. Yeah, I'm not kidding.

0:20:30.560 --> 0:20:33.480
<v Speaker 1>When we were in Chicago and I'm just sitting there

0:20:33.520 --> 0:20:36.399
<v Speaker 1>looking at Sue for a while, I did something to me,

0:20:36.480 --> 0:20:40.119
<v Speaker 1>like a little misty. That's that's beautiful. I I can

0:20:40.200 --> 0:20:42.160
<v Speaker 1>understand it because it is like looking back in time

0:20:42.200 --> 0:20:46.119
<v Speaker 1>to encounter, you know, a fossil like that. So Sue

0:20:46.160 --> 0:20:49.959
<v Speaker 1>is a rather big specimen, or at least the fossil

0:20:50.040 --> 0:20:52.760
<v Speaker 1>remains are rather large and speak to a large specimen.

0:20:53.640 --> 0:20:57.080
<v Speaker 1>They We think now that she probably achieved adult size

0:20:57.119 --> 0:20:59.440
<v Speaker 1>at age twenty and lived to a ripe old age

0:20:59.440 --> 0:21:04.760
<v Speaker 1>of twenty. Wow, so I am now older than than

0:21:04.800 --> 0:21:09.480
<v Speaker 1>this Tyrannosaurus rex was when it dies exactly. Yeah, and uh,

0:21:09.640 --> 0:21:11.439
<v Speaker 1>and it just underlines that what you had with the

0:21:11.440 --> 0:21:16.080
<v Speaker 1>dinosaurs was likely rapid growth but short lives. Now, one

0:21:16.240 --> 0:21:19.119
<v Speaker 1>sort of side question that we won't fully explore. But

0:21:19.240 --> 0:21:22.240
<v Speaker 1>this this may raise the question, well, dinosaurs have cancer

0:21:22.520 --> 0:21:25.639
<v Speaker 1>because you're thinking about rapid growth, right of course. Well,

0:21:26.200 --> 0:21:27.960
<v Speaker 1>basically this is the question we have to come back to.

0:21:28.000 --> 0:21:30.360
<v Speaker 1>But based on the research I was looking at, we

0:21:30.440 --> 0:21:34.320
<v Speaker 1>only have evidence of the hadrosaurs, the duck build dinosaurs

0:21:34.880 --> 0:21:38.160
<v Speaker 1>developing any form of cancer. Now that's the caveat that's

0:21:38.200 --> 0:21:41.359
<v Speaker 1>the only the only ones we have evidence of that

0:21:41.359 --> 0:21:44.199
<v Speaker 1>that occurring in. But it is interesting to think of

0:21:44.240 --> 0:21:47.240
<v Speaker 1>like the late model dinosaur as being the place where

0:21:47.280 --> 0:21:50.000
<v Speaker 1>we see the cancer showing up. We gotta come back

0:21:50.040 --> 0:21:52.600
<v Speaker 1>and do an episode on dinosaur cancer in the future. Yeah,

0:21:52.640 --> 0:21:54.760
<v Speaker 1>by all means, well, I want to do something that

0:21:54.800 --> 0:21:56.600
<v Speaker 1>we often end up having to do, which is that

0:21:56.680 --> 0:21:59.440
<v Speaker 1>after we've explored a concept for a while, it becomes

0:21:59.480 --> 0:22:03.359
<v Speaker 1>more and more complicated and our lay definition starts to

0:22:03.400 --> 0:22:07.080
<v Speaker 1>get a little less useful. So I think maybe we

0:22:07.080 --> 0:22:11.760
<v Speaker 1>should ask the question what actually is aging? Now? We

0:22:11.800 --> 0:22:15.840
<v Speaker 1>we have a pretty uh intuitive, gut level understanding of

0:22:15.840 --> 0:22:18.040
<v Speaker 1>what aging is. We know when we see it, But

0:22:18.119 --> 0:22:20.359
<v Speaker 1>how would you define it? I mean, it's it is

0:22:20.440 --> 0:22:25.600
<v Speaker 1>something different from death, and it is something different from

0:22:25.640 --> 0:22:28.600
<v Speaker 1>just like, I don't know your skin getting wrinkles or

0:22:28.680 --> 0:22:31.480
<v Speaker 1>something like that. What what is the actual scientific thing

0:22:31.560 --> 0:22:36.440
<v Speaker 1>that all of the stuff we call aging has in common. Well,

0:22:36.440 --> 0:22:40.440
<v Speaker 1>this is a great question. I mean, on one hand,

0:22:39.800 --> 0:22:42.919
<v Speaker 1>it is closely tied to death, and I think one

0:22:42.920 --> 0:22:45.320
<v Speaker 1>of the stumbling blocks is that will will alreadily admit

0:22:45.359 --> 0:22:48.000
<v Speaker 1>that aging is something that our body does, but we

0:22:48.080 --> 0:22:50.280
<v Speaker 1>tend there's tends to tend to be a cultural barrier

0:22:50.359 --> 0:22:53.040
<v Speaker 1>in place to saying that death is something our body does.

0:22:53.480 --> 0:22:55.879
<v Speaker 1>We like to push that off onto some sort of

0:22:55.920 --> 0:23:01.199
<v Speaker 1>external force of of fade or anthropomorphy, eyes dread, you know,

0:23:01.359 --> 0:23:04.720
<v Speaker 1>or some sort of limit imposed on us by the gods. Well, yeah, yeah,

0:23:04.800 --> 0:23:08.280
<v Speaker 1>death is something that we more often characterize as happening

0:23:08.359 --> 0:23:13.000
<v Speaker 1>to us. Death happens to you. It's not something you do. Though.

0:23:13.320 --> 0:23:16.040
<v Speaker 1>There you can kind of see that the division between

0:23:16.240 --> 0:23:18.840
<v Speaker 1>the death and the aging death I was talking about

0:23:18.840 --> 0:23:21.320
<v Speaker 1>at the beginning of this episode comes into focus, because

0:23:21.680 --> 0:23:23.920
<v Speaker 1>of course, death can happen to you if you get

0:23:23.960 --> 0:23:26.440
<v Speaker 1>a rock jammed through your you know, through your body

0:23:26.520 --> 0:23:29.560
<v Speaker 1>or something like that. But the body does seem to

0:23:29.720 --> 0:23:34.560
<v Speaker 1>naturally progress toward death over time. And that's kind of

0:23:34.600 --> 0:23:37.680
<v Speaker 1>a weird question, like why would it do that. We

0:23:37.680 --> 0:23:40.600
<v Speaker 1>will definitely explore the science behind that question in the

0:23:40.640 --> 0:23:43.800
<v Speaker 1>second episode that we will look at some archaic answers

0:23:43.800 --> 0:23:46.080
<v Speaker 1>to it in this one, because when especially with the human,

0:23:46.240 --> 0:23:50.240
<v Speaker 1>with the human experience of aging and death, it seems

0:23:50.320 --> 0:23:54.280
<v Speaker 1>completely illogical that in many cases a human being would

0:23:54.320 --> 0:23:58.639
<v Speaker 1>spend the majority of its life progressing towards death, like

0:23:58.760 --> 0:24:02.119
<v Speaker 1>the majority of your life. His decline, Uh, that just

0:24:02.400 --> 0:24:07.080
<v Speaker 1>feels either gross or cruel or just like a horrible

0:24:07.080 --> 0:24:10.720
<v Speaker 1>design flaw, or yeah, or nonsensical. But where's my eternal

0:24:10.760 --> 0:24:14.240
<v Speaker 1>youth doesn't make any sense? Um. So in his nine

0:24:15.200 --> 0:24:19.480
<v Speaker 1>book The Evolutionary Biology of Aging, published by Oxford University Press,

0:24:19.840 --> 0:24:23.560
<v Speaker 1>the biologist Michael R. Rose defined aging in the following

0:24:23.600 --> 0:24:28.720
<v Speaker 1>way quote a persistent decline in the age specific fitness

0:24:28.800 --> 0:24:35.840
<v Speaker 1>components of an organism due to internal physiological deterioration. Now

0:24:35.920 --> 0:24:38.760
<v Speaker 1>Rose actually has offered has said that in some ways

0:24:38.800 --> 0:24:41.040
<v Speaker 1>we might need to update that understanding a little bit

0:24:41.040 --> 0:24:43.520
<v Speaker 1>to accommodate for some new discoveries. But I think this

0:24:43.600 --> 0:24:46.280
<v Speaker 1>is a good place to start. So let's look at

0:24:46.280 --> 0:24:49.520
<v Speaker 1>the parts of that definition. Number one, it's persistent decline,

0:24:49.880 --> 0:24:53.600
<v Speaker 1>which means aging only goes one way. It's not characterized

0:24:53.640 --> 0:24:57.560
<v Speaker 1>by say decline and rebound, and some organisms do have

0:24:57.760 --> 0:25:00.119
<v Speaker 1>patterns like this, it is not quite aging, like you

0:25:00.119 --> 0:25:04.040
<v Speaker 1>can think about the jellyfish that have regenerative capabilities where

0:25:04.080 --> 0:25:07.800
<v Speaker 1>they can revert to a younger stage of life. But

0:25:07.840 --> 0:25:10.840
<v Speaker 1>then so it's persistent decline. And then in the quote

0:25:11.160 --> 0:25:16.119
<v Speaker 1>age specific fitness components biological fitness meaning the ability to

0:25:16.200 --> 0:25:19.680
<v Speaker 1>survive and reproduce. So these are the things that are

0:25:19.680 --> 0:25:23.320
<v Speaker 1>persistently in decline. You become less able to survive and

0:25:23.440 --> 0:25:27.840
<v Speaker 1>less able to reproduce. And then it's due to internal

0:25:27.880 --> 0:25:32.359
<v Speaker 1>physiological deterioration. So it's saying that this persistent decline in

0:25:32.400 --> 0:25:35.720
<v Speaker 1>the ability to survive and reproduce is not due to

0:25:35.920 --> 0:25:41.119
<v Speaker 1>disease or injury, but to something deteriorating within the body

0:25:41.160 --> 0:25:45.120
<v Speaker 1>tissues themselves. Yeah, this is this makes me think, of course,

0:25:45.119 --> 0:25:48.000
<v Speaker 1>of the phrase cradle to the grave and with it

0:25:48.080 --> 0:25:50.359
<v Speaker 1>with the hydra. The cradle to the grave is kind

0:25:50.359 --> 0:25:53.920
<v Speaker 1>of a straight line with reproduction taking place at all

0:25:54.040 --> 0:25:59.720
<v Speaker 1>levels until something happens to kill it. Whereas most of

0:25:59.720 --> 0:26:01.399
<v Speaker 1>them models that that we look at, most of the

0:26:01.440 --> 0:26:04.040
<v Speaker 1>models we looked at in researching this episode, it's more

0:26:04.119 --> 0:26:07.879
<v Speaker 1>of a of a rise rising and lowering. There's a

0:26:08.080 --> 0:26:13.040
<v Speaker 1>rise towards like peak sexual maturity, peak reproductive maturity, and

0:26:13.080 --> 0:26:16.560
<v Speaker 1>then a decline. Yeah uh yeah, And then it gets

0:26:16.560 --> 0:26:18.679
<v Speaker 1>even stickier, right because we we've just tried to be

0:26:18.800 --> 0:26:20.800
<v Speaker 1>very careful and how we're defining this. But then I

0:26:20.840 --> 0:26:23.639
<v Speaker 1>realized that I said the it's a decline in the

0:26:23.680 --> 0:26:28.040
<v Speaker 1>ability to survive and reproduce, not due to disease or injury.

0:26:28.080 --> 0:26:30.760
<v Speaker 1>But a lot of the things that are the characteristic

0:26:30.840 --> 0:26:36.320
<v Speaker 1>signals of aging are sometimes thought of as diseases, even

0:26:36.320 --> 0:26:41.320
<v Speaker 1>though maybe they're not caused by say a germ or something. Uh.

0:26:41.359 --> 0:26:45.639
<v Speaker 1>There are all kinds of things like diabetes melitas, or

0:26:45.920 --> 0:26:50.760
<v Speaker 1>like rheumatoid arthritis that are totally characteristic signs of aging

0:26:50.800 --> 0:26:54.240
<v Speaker 1>and human beings, and they're thought of as diseases, but

0:26:54.280 --> 0:26:56.840
<v Speaker 1>they're not so much something that gets done to the

0:26:56.880 --> 0:27:00.359
<v Speaker 1>body by external forces. There are a thing that happens

0:27:00.440 --> 0:27:02.880
<v Speaker 1>when the body is around for a long time under

0:27:02.920 --> 0:27:06.200
<v Speaker 1>certain conditions. It makes me think back to our episode

0:27:06.200 --> 0:27:09.360
<v Speaker 1>on Chinese immortality and about the the idea of the

0:27:09.359 --> 0:27:13.000
<v Speaker 1>the older body being kind of an alien body, Like

0:27:13.040 --> 0:27:16.920
<v Speaker 1>it's a different biology we're changing into a different being

0:27:18.320 --> 0:27:23.760
<v Speaker 1>with different physical characteristics. Generally characterists that that leaned towards

0:27:24.240 --> 0:27:27.680
<v Speaker 1>towards weakness. Absolutely, But then again, you can also look

0:27:27.720 --> 0:27:30.800
<v Speaker 1>at aging through the microscope, look at it on the

0:27:30.840 --> 0:27:33.760
<v Speaker 1>cellular level, and this is where you'll often see people

0:27:33.880 --> 0:27:39.240
<v Speaker 1>using words like sinescence. Defined by by Nature's scientific glossary quote,

0:27:39.600 --> 0:27:44.320
<v Speaker 1>senescence is the process by which sells irreversibly stop dividing

0:27:44.800 --> 0:27:48.879
<v Speaker 1>and inter a state of permanent growth arrest without undergoing

0:27:49.000 --> 0:27:53.800
<v Speaker 1>cell death. Senescence can be induced by unrepaired DNA damage

0:27:53.880 --> 0:27:57.080
<v Speaker 1>or other cellular stresses. So this is looking at it

0:27:57.119 --> 0:28:01.679
<v Speaker 1>on the microscopic level and saying in essence, often used

0:28:01.720 --> 0:28:05.040
<v Speaker 1>as as a synonym for aging, happens when the cells

0:28:05.280 --> 0:28:09.920
<v Speaker 1>stop making new rejuvenated cells. This is kind of the

0:28:10.600 --> 0:28:13.760
<v Speaker 1>lack of upkeep keep model. It's the idea that well,

0:28:13.800 --> 0:28:16.320
<v Speaker 1>the house is falling apart because nobody's working on it,

0:28:16.359 --> 0:28:19.520
<v Speaker 1>nobody's maintaining, or at least the maintenance has really been

0:28:19.560 --> 0:28:23.240
<v Speaker 1>scaled back or it's all. It's it's been my experience

0:28:23.280 --> 0:28:27.200
<v Speaker 1>thus far with aging that you find the maintenance requests

0:28:27.320 --> 0:28:30.640
<v Speaker 1>are are kind of rolled out in in a logical

0:28:30.680 --> 0:28:33.600
<v Speaker 1>way where you're you're like, you may think to yourself, well,

0:28:33.600 --> 0:28:36.640
<v Speaker 1>why am I still sore from this injury I sustained

0:28:36.720 --> 0:28:39.760
<v Speaker 1>last month? But my my, what my body is really

0:28:39.760 --> 0:28:42.200
<v Speaker 1>trying to do is like grow a bunch of nose hair.

0:28:42.680 --> 0:28:45.640
<v Speaker 1>You know, It's like, why why is that the the

0:28:46.280 --> 0:28:49.560
<v Speaker 1>main operative that's been passed down to my body? You know,

0:28:49.800 --> 0:28:51.520
<v Speaker 1>everything is beginning to get out of whack. It's as

0:28:51.560 --> 0:28:55.200
<v Speaker 1>if it's as if there's nobody in charge anymore. Uh,

0:28:55.280 --> 0:28:58.480
<v Speaker 1>and they're just letting the house fall apart. Yeah. If

0:28:58.520 --> 0:29:01.520
<v Speaker 1>you were the super tendon of an apartment building, it

0:29:01.520 --> 0:29:04.160
<v Speaker 1>would be like, there's a water leak in the basement

0:29:04.280 --> 0:29:07.480
<v Speaker 1>that has not been fixed for months, and your repair

0:29:07.560 --> 0:29:10.960
<v Speaker 1>person is busy building hundreds of kitchen cabinets on the roof.

0:29:11.200 --> 0:29:13.280
<v Speaker 1>Yeah yeah, And you think, well, in the old days,

0:29:13.680 --> 0:29:15.760
<v Speaker 1>we we didn't have all these kitchen cabinets on the roof,

0:29:15.840 --> 0:29:18.120
<v Speaker 1>and things got fixed. Why did things not got to

0:29:18.160 --> 0:29:20.480
<v Speaker 1>get fixed anymore? That is a great question, and I

0:29:20.520 --> 0:29:23.560
<v Speaker 1>guess we should try to look at some answers to

0:29:23.600 --> 0:29:28.160
<v Speaker 1>that when we come back from this next break. Thank alright,

0:29:28.160 --> 0:29:30.840
<v Speaker 1>we're back, all right, So let's look at some historical

0:29:31.000 --> 0:29:34.240
<v Speaker 1>and lay answers to the question why do we age?

0:29:34.280 --> 0:29:38.640
<v Speaker 1>What's the point? Why does it happen? One common example

0:29:38.680 --> 0:29:40.880
<v Speaker 1>that seems to make sense to people is the idea

0:29:40.920 --> 0:29:45.520
<v Speaker 1>that our body is, over time quote get worn out. Uh.

0:29:45.560 --> 0:29:49.440
<v Speaker 1>So in his nine seven paper Pleotropy, Natural Selection and

0:29:49.440 --> 0:29:52.080
<v Speaker 1>the Evolution of Senescence, which we will definitely come back

0:29:52.120 --> 0:29:55.800
<v Speaker 1>to in the second episode, here, the American biologist George C.

0:29:56.040 --> 0:30:00.680
<v Speaker 1>Williams pointed out that one problem explaining the true biological

0:30:01.280 --> 0:30:04.920
<v Speaker 1>reason behind aging is that many people think they already

0:30:05.000 --> 0:30:08.440
<v Speaker 1>understand what aging is and why it happens, and they're wrong.

0:30:09.120 --> 0:30:11.360
<v Speaker 1>They're wrong. But if you think you've already got the answer,

0:30:11.400 --> 0:30:14.120
<v Speaker 1>you'll never go asking the question and writing of these

0:30:14.200 --> 0:30:18.840
<v Speaker 1>kind of folk explanations for aging. He says, quote the

0:30:18.920 --> 0:30:22.680
<v Speaker 1>most injurious of these is the identification of sinescence with

0:30:22.800 --> 0:30:27.280
<v Speaker 1>the quote wearing out that is shown by human artifacts.

0:30:27.840 --> 0:30:30.960
<v Speaker 1>And doesn't this seem very sensical? Right? Our tools get

0:30:31.000 --> 0:30:33.840
<v Speaker 1>worn out over time. If you use a knife a

0:30:33.880 --> 0:30:37.280
<v Speaker 1>whole lot, eventually it'll lose the sharpness of its blade.

0:30:37.760 --> 0:30:40.720
<v Speaker 1>Uh any tool you use too much. I'm thinking about

0:30:40.720 --> 0:30:43.800
<v Speaker 1>a broom that we used to have for years around

0:30:43.840 --> 0:30:46.160
<v Speaker 1>our house that eventually got worn down to nubs. There

0:30:46.160 --> 0:30:48.840
<v Speaker 1>were just really no bristles on it anymore. Shouldn't our

0:30:48.880 --> 0:30:52.480
<v Speaker 1>bodies be the same. This reminds me I've had to

0:30:52.480 --> 0:30:54.960
<v Speaker 1>explain this to my my son recently, where he'll get

0:30:55.640 --> 0:30:57.680
<v Speaker 1>some sort of cheap toy, you know, as a prize

0:30:57.800 --> 0:31:01.160
<v Speaker 1>or something, and he'll be really into it. I'll have

0:31:01.160 --> 0:31:03.200
<v Speaker 1>to explain to him that this is not the sort

0:31:03.240 --> 0:31:06.040
<v Speaker 1>of toy that lasts very long. You know, toys like

0:31:06.120 --> 0:31:09.800
<v Speaker 1>this may last a week or so, and and he's like, no,

0:31:09.880 --> 0:31:11.960
<v Speaker 1>if some some toys last forever. And I'm like, well,

0:31:12.080 --> 0:31:14.440
<v Speaker 1>they don't. They don't really, And you have to try

0:31:14.480 --> 0:31:18.160
<v Speaker 1>to explain how pretty much everything that is made by

0:31:18.280 --> 0:31:21.479
<v Speaker 1>man is going to fall apart. Okay, after I finished

0:31:21.520 --> 0:31:24.600
<v Speaker 1>my children's book about ming the Clam, I'm writing a

0:31:24.640 --> 0:31:28.920
<v Speaker 1>second children's book called Toys Die. What it reminds me

0:31:28.960 --> 0:31:32.720
<v Speaker 1>of the short story that that A I was was

0:31:32.760 --> 0:31:35.080
<v Speaker 1>based on. Oh yeah, I forget the exact title, but

0:31:35.120 --> 0:31:37.880
<v Speaker 1>to believe it was super Toys Last All Summer, which

0:31:37.880 --> 0:31:42.120
<v Speaker 1>I always thought was a rather fun title. That is great,

0:31:42.200 --> 0:31:45.240
<v Speaker 1>but knowing knowing that we also know that they won't

0:31:45.320 --> 0:31:48.360
<v Speaker 1>last forever, like you, like you say, so, going back

0:31:48.360 --> 0:31:52.640
<v Speaker 1>to what Williams wrote, quote, A moment of serious consideration

0:31:52.640 --> 0:31:56.920
<v Speaker 1>should convince a biologist of the fundamental dissimilarity between these

0:31:56.960 --> 0:32:01.280
<v Speaker 1>two processes, meaning the body wearing out and tools wearing out.

0:32:01.320 --> 0:32:05.040
<v Speaker 1>The breakdown of human artifacts is strictly mechanical and is

0:32:05.080 --> 0:32:09.800
<v Speaker 1>readily cured by mechanical repairs. The system is a static one,

0:32:10.240 --> 0:32:14.040
<v Speaker 1>since the same material is continuously present and there is

0:32:14.120 --> 0:32:18.400
<v Speaker 1>no endogenous change with the passage of time. An organism,

0:32:18.480 --> 0:32:21.120
<v Speaker 1>on the other hand, is an open system in a

0:32:21.160 --> 0:32:26.120
<v Speaker 1>state of material flux. Even such structures as bones maintain

0:32:26.280 --> 0:32:31.440
<v Speaker 1>constant exchanges with the environment. Moreover, an organism produces itself

0:32:31.480 --> 0:32:35.800
<v Speaker 1>by a morphogenetic process. It is indeed remarkable that after

0:32:35.880 --> 0:32:40.240
<v Speaker 1>a seemingly miraculous feat of morphogenesis, and that means like

0:32:40.320 --> 0:32:44.720
<v Speaker 1>growing into the adult shape, a metazoan should be unable

0:32:44.760 --> 0:32:48.360
<v Speaker 1>to perform the much simpler task of merely maintaining what

0:32:48.560 --> 0:32:51.480
<v Speaker 1>is already formed. I think this is a fantastic point.

0:32:51.520 --> 0:32:53.440
<v Speaker 1>I mean, it doesn't make sense to say we get

0:32:53.520 --> 0:32:56.080
<v Speaker 1>old because over time our bodies just get worn out,

0:32:56.120 --> 0:32:59.560
<v Speaker 1>because our bodies have the ability to rejuvenate tissues. They

0:32:59.640 --> 0:33:02.200
<v Speaker 1>built tissues in the first place. They could just keep

0:33:02.280 --> 0:33:05.280
<v Speaker 1>building them as long as they wanted. Yeah, I mean,

0:33:05.360 --> 0:33:07.400
<v Speaker 1>I think part of this is the I mean part

0:33:07.400 --> 0:33:08.920
<v Speaker 1>of it is just that we are so close to

0:33:09.000 --> 0:33:11.600
<v Speaker 1>the aging process. We experience it, and we see it

0:33:11.640 --> 0:33:14.480
<v Speaker 1>in others. Uh, We're almost too close to it to

0:33:14.480 --> 0:33:17.320
<v Speaker 1>have an objective view of it. And then to your point,

0:33:17.400 --> 0:33:20.880
<v Speaker 1>we're informed by what happens to our tools. And then

0:33:20.920 --> 0:33:24.240
<v Speaker 1>I also they're tying into the experience as well, and

0:33:24.240 --> 0:33:27.600
<v Speaker 1>the wearing out of things. I think dental health has

0:33:27.680 --> 0:33:29.800
<v Speaker 1>a has a huge impact on it because we observe

0:33:30.200 --> 0:33:33.520
<v Speaker 1>this happening with our very teeth, the teeth of others

0:33:33.560 --> 0:33:36.560
<v Speaker 1>that you get that those adult teeth in and those

0:33:36.560 --> 0:33:38.920
<v Speaker 1>are the ones you're gonna have for the rest of

0:33:38.920 --> 0:33:41.000
<v Speaker 1>your life as long as you can keep them. You know,

0:33:41.560 --> 0:33:44.680
<v Speaker 1>they are going to wear out, and unlike other organisms,

0:33:44.680 --> 0:33:47.640
<v Speaker 1>there's not going to be an additional h set there

0:33:47.840 --> 0:33:52.320
<v Speaker 1>that are going to lock into place. Third children's book

0:33:52.640 --> 0:33:55.480
<v Speaker 1>for when children get their baby teeth knocked out, it's

0:33:55.520 --> 0:34:00.240
<v Speaker 1>called this is your Last Chance. Yeah. I've actually heard

0:34:00.320 --> 0:34:03.720
<v Speaker 1>uh parents, I think half joking, we talk about not

0:34:03.840 --> 0:34:06.480
<v Speaker 1>worrying with brushing that much for young children because now

0:34:06.520 --> 0:34:08.880
<v Speaker 1>they're gonna gore gonna get that second pit. You know

0:34:08.880 --> 0:34:11.040
<v Speaker 1>they're gonna be These are not even These are just

0:34:11.080 --> 0:34:12.880
<v Speaker 1>the baby teeth. Wait till the adult teeth come in

0:34:12.920 --> 0:34:17.719
<v Speaker 1>and then start worrying. Yeah. Now, beyond these simple folk explanations,

0:34:17.719 --> 0:34:19.880
<v Speaker 1>we know that there have been lots of thinkers throughout

0:34:19.920 --> 0:34:23.440
<v Speaker 1>history who must have tried to explain why aging happens

0:34:23.480 --> 0:34:27.239
<v Speaker 1>before we had modern modern genetics to really understand the

0:34:27.280 --> 0:34:30.920
<v Speaker 1>true mechanisms. Right, Yeah, this is you know, aging is

0:34:31.280 --> 0:34:33.040
<v Speaker 1>part of the human experience, and so some of the

0:34:33.080 --> 0:34:36.400
<v Speaker 1>great thinkers and human history have pondered it. We have

0:34:36.440 --> 0:34:40.440
<v Speaker 1>a few examples here to run through. For instance, Lucretius

0:34:41.160 --> 0:34:44.520
<v Speaker 1>through fifty five b c uh he wrote about it

0:34:44.560 --> 0:34:48.279
<v Speaker 1>in his text on the Nature of Things, and he

0:34:48.480 --> 0:34:50.839
<v Speaker 1>argued that aging and death are beneficial because they make

0:34:50.920 --> 0:34:53.920
<v Speaker 1>room for the next generation. This is probably another folk

0:34:54.000 --> 0:34:56.800
<v Speaker 1>explanation a lot of people would employ. Right, totally seems

0:34:56.840 --> 0:34:59.239
<v Speaker 1>to make sense. You can't just keep living forever because

0:34:59.239 --> 0:35:01.759
<v Speaker 1>you've gotta make room for the next generation. Yeah. It

0:35:02.280 --> 0:35:06.240
<v Speaker 1>especially makes a sort of sense, I think for human

0:35:06.239 --> 0:35:09.560
<v Speaker 1>populations when you have, say, individuals who have over the

0:35:09.560 --> 0:35:15.160
<v Speaker 1>course of their lifetime accumulated certain benefits and powers and possessions,

0:35:15.520 --> 0:35:18.000
<v Speaker 1>and then the idea as well, when they fall away,

0:35:18.600 --> 0:35:20.960
<v Speaker 1>those resources spread to someone else, you know, I mean

0:35:20.960 --> 0:35:24.000
<v Speaker 1>we we we have always lived in a world of

0:35:24.000 --> 0:35:27.279
<v Speaker 1>of finite resources. And I want to be clear, it

0:35:27.600 --> 0:35:31.279
<v Speaker 1>is good that that happens. The next generations actually do

0:35:31.480 --> 0:35:36.120
<v Speaker 1>benefit from the fact that older generations grow old and die. Uh,

0:35:36.160 --> 0:35:38.839
<v Speaker 1>But there are some serious problems with thinking about this

0:35:38.920 --> 0:35:43.120
<v Speaker 1>as the reason biologically that they grow old and die. Yeah.

0:35:43.360 --> 0:35:46.760
<v Speaker 1>Though this this observation persisted well up into the twentieth century.

0:35:46.920 --> 0:35:51.560
<v Speaker 1>For instance, nineteenth century German biologist August Weissmann also believe

0:35:51.640 --> 0:35:54.280
<v Speaker 1>that the death mechanism created room for the next generation

0:35:54.320 --> 0:35:57.600
<v Speaker 1>of young to thrive at And you know, I have

0:35:57.680 --> 0:35:59.840
<v Speaker 1>to men as well that I always it always always

0:36:00.040 --> 0:36:01.920
<v Speaker 1>kind of felt this was the case, you know, at

0:36:01.960 --> 0:36:05.359
<v Speaker 1>a gut level, without putting a lot of serious thought

0:36:05.400 --> 0:36:08.280
<v Speaker 1>behind it. Oh yeah, before I investigated this, I assumed

0:36:08.320 --> 0:36:10.720
<v Speaker 1>something along these lines. But then I started to doubt

0:36:10.719 --> 0:36:13.000
<v Speaker 1>myself because I was like, oh, wait a minute, that's

0:36:13.000 --> 0:36:16.360
<v Speaker 1>group selection, and I always feel iffy about that. The

0:36:16.400 --> 0:36:19.200
<v Speaker 1>problem here is pointed out by Daniel Fabian of the

0:36:19.239 --> 0:36:23.560
<v Speaker 1>Institute of Population Genetics in in the publication nature is

0:36:23.600 --> 0:36:27.200
<v Speaker 1>that quote, the cost of death to individuals likely exceeds

0:36:27.200 --> 0:36:30.440
<v Speaker 1>the benefit to the group or species. And because long

0:36:30.680 --> 0:36:35.040
<v Speaker 1>lived individuals leave more offspring than short lived individuals given

0:36:35.040 --> 0:36:40.960
<v Speaker 1>equivalent reproductive output, selection would not favor such a death mechanism. Yeah.

0:36:41.040 --> 0:36:44.360
<v Speaker 1>This is one of the classic arguments against any kind

0:36:44.400 --> 0:36:48.560
<v Speaker 1>of group level selection influence. And we can revisit this

0:36:48.640 --> 0:36:51.640
<v Speaker 1>in more detail in the second episode. Now, of course,

0:36:51.680 --> 0:36:56.920
<v Speaker 1>another great thinker is Aristotle, right, yeah, and he of

0:36:56.920 --> 0:37:00.239
<v Speaker 1>course wrote about this as well in on Longevity and

0:37:00.360 --> 0:37:03.960
<v Speaker 1>Shortness of Life. Aristotle tell us how it is all right? Well,

0:37:05.200 --> 0:37:07.279
<v Speaker 1>before I go get going here, I do want to

0:37:07.280 --> 0:37:08.919
<v Speaker 1>point out I I am going to be the last

0:37:08.960 --> 0:37:13.759
<v Speaker 1>person to to criticize Aristotle. Uh uh. I feel like

0:37:13.800 --> 0:37:16.520
<v Speaker 1>he uh he did did a lot with the wisdom

0:37:16.560 --> 0:37:20.279
<v Speaker 1>of the day, obviously, and that's an understatement. Uh, but

0:37:20.400 --> 0:37:22.800
<v Speaker 1>he was not able. We're not going to take the

0:37:22.840 --> 0:37:27.080
<v Speaker 1>opinion that Aristotle was dumb though I was talking. I

0:37:27.080 --> 0:37:29.080
<v Speaker 1>was actually talking about this with my my wife last

0:37:29.160 --> 0:37:32.000
<v Speaker 1>night when I was running through the material I'm about

0:37:32.040 --> 0:37:34.800
<v Speaker 1>to uh to relate here, and she said, well, that

0:37:34.840 --> 0:37:37.839
<v Speaker 1>would actually make a wonderful like BuzzFeed style article like

0:37:38.160 --> 0:37:41.120
<v Speaker 1>six things that dummy Aristotle got wrong. I mean, he

0:37:41.800 --> 0:37:43.960
<v Speaker 1>got a lot of stuff wrong, but I mean everybody

0:37:44.000 --> 0:37:45.720
<v Speaker 1>in the ancient world did. Yeah, I mean he people

0:37:45.760 --> 0:37:47.640
<v Speaker 1>just didn't know what we knew today, right, And he

0:37:47.640 --> 0:37:50.040
<v Speaker 1>was attempting and attempting to figure it out. He threw

0:37:50.080 --> 0:37:52.480
<v Speaker 1>out a number of hypotheses that were not They did

0:37:52.480 --> 0:37:55.840
<v Speaker 1>not shake out. So here are just a few quotes

0:37:55.880 --> 0:37:58.359
<v Speaker 1>from the work that will give you an idea of

0:37:58.360 --> 0:38:00.520
<v Speaker 1>where he was going the re sa since for some

0:38:00.600 --> 0:38:03.160
<v Speaker 1>animals being long lived and other short lived, and in

0:38:03.200 --> 0:38:06.400
<v Speaker 1>a word, causes of the length and brevity of life,

0:38:06.600 --> 0:38:10.919
<v Speaker 1>call for investigation. Fair enough, same question we're asking why

0:38:10.960 --> 0:38:13.520
<v Speaker 1>does it happen? And then he goes on to say

0:38:13.800 --> 0:38:16.959
<v Speaker 1>race is inhabiting warm countries have longer life, those living

0:38:16.960 --> 0:38:20.080
<v Speaker 1>in cold climates have a shorter time. Likewise, there are

0:38:20.120 --> 0:38:23.879
<v Speaker 1>similar differences among individuals occupying the same locality. I don't

0:38:23.880 --> 0:38:26.440
<v Speaker 1>know if that's true. I mean, we already touched on

0:38:26.480 --> 0:38:29.080
<v Speaker 1>the greenland shark, and I think we've gone more in

0:38:29.120 --> 0:38:31.359
<v Speaker 1>depth in the greenland shark in the past on this show.

0:38:31.440 --> 0:38:36.600
<v Speaker 1>But part of it is its environment, which is quite cold. Uh.

0:38:36.640 --> 0:38:39.840
<v Speaker 1>He also commented on the connection between the soul and

0:38:39.880 --> 0:38:42.399
<v Speaker 1>the body. The soul must stand in a different case

0:38:42.520 --> 0:38:46.680
<v Speaker 1>in respect of its union with the body. And then

0:38:46.760 --> 0:38:50.399
<v Speaker 1>this at least rings true, hints to all things are

0:38:50.480 --> 0:38:53.160
<v Speaker 1>at all times in a state of transition and are

0:38:53.200 --> 0:38:56.880
<v Speaker 1>coming into being and passing away. Okay, so this could

0:38:56.920 --> 0:38:59.719
<v Speaker 1>be interpreted to mean something kind of like the fact

0:38:59.719 --> 0:39:03.400
<v Speaker 1>that we're constantly undergoing cell division and our bodies maintain

0:39:03.520 --> 0:39:06.000
<v Speaker 1>them I mean, obviously Aristotle didn't know this, but that

0:39:06.040 --> 0:39:10.560
<v Speaker 1>our bodies maintain themselves through cell division and repair of tissues. Yes.

0:39:10.640 --> 0:39:14.080
<v Speaker 1>And then there's this quote speaking generally, the longest lived

0:39:14.120 --> 0:39:18.080
<v Speaker 1>things occur among the plants, uh, example of the date palm. Next,

0:39:18.120 --> 0:39:21.279
<v Speaker 1>in order we find them among the sanguineous animals rather

0:39:21.320 --> 0:39:24.560
<v Speaker 1>than among the bloodless, and among those with feet rather

0:39:24.600 --> 0:39:28.200
<v Speaker 1>than among the denizens of the water. Hence, taking these

0:39:28.200 --> 0:39:32.319
<v Speaker 1>two characters together, the longest lived animals fall among sanguineous

0:39:32.360 --> 0:39:36.320
<v Speaker 1>animals which have feet. Uh. Men and elephants. Well, clearly

0:39:36.360 --> 0:39:39.800
<v Speaker 1>we've learned how to make your aquarium fish live longer.

0:39:40.120 --> 0:39:44.120
<v Speaker 1>You transplant some feet onto them. Uh. This at least

0:39:44.120 --> 0:39:46.120
<v Speaker 1>as good quote. As a matter of fact. Also, it

0:39:46.239 --> 0:39:49.319
<v Speaker 1>is a general rule that the larger live longer than

0:39:49.320 --> 0:39:53.520
<v Speaker 1>the smaller. For the other long lived animals to happen

0:39:53.600 --> 0:39:56.600
<v Speaker 1>to be of a large size are also those I

0:39:56.640 --> 0:40:00.480
<v Speaker 1>have mentioned. Now, I'm sure this is not hard and

0:40:00.560 --> 0:40:03.040
<v Speaker 1>fast rule, though I think there are probably some weak

0:40:03.160 --> 0:40:05.480
<v Speaker 1>correlations along these lines. I think so. I mean, we

0:40:05.520 --> 0:40:08.520
<v Speaker 1>already touched on the dinosaur thing, but but certainly there

0:40:08.560 --> 0:40:12.440
<v Speaker 1>are some examples of rather large animals that have longer

0:40:12.480 --> 0:40:17.960
<v Speaker 1>lifespans within typical longevity. Now Aristotle's working theory, though, is

0:40:18.000 --> 0:40:22.680
<v Speaker 1>that all of it revolves around moisture in an organism. Yes, quote,

0:40:22.680 --> 0:40:25.280
<v Speaker 1>we must remember that an animal is by nature human

0:40:25.320 --> 0:40:27.719
<v Speaker 1>and warm, and to live is to be of such

0:40:27.760 --> 0:40:31.040
<v Speaker 1>a constitution, while old age is dry and cold, and

0:40:31.120 --> 0:40:34.279
<v Speaker 1>so is a corpse. I think Aristotle also tried to

0:40:35.120 --> 0:40:41.080
<v Speaker 1>explain earthquakes by way of moisture, maybe misremembering them. And

0:40:41.280 --> 0:40:43.959
<v Speaker 1>he also said that aquatic animals don't count here because

0:40:43.960 --> 0:40:47.560
<v Speaker 1>they're not humid. Their watery and quote watery moisture is

0:40:47.560 --> 0:40:52.040
<v Speaker 1>easily destroyed since it is cold and readily congealed. And finally,

0:40:52.040 --> 0:40:54.439
<v Speaker 1>he also throws in four in animals, the males are

0:40:54.480 --> 0:40:57.879
<v Speaker 1>in general the longer lived. I don't think that's true either. Yeah,

0:40:57.880 --> 0:41:00.319
<v Speaker 1>I believe in in in in many cases it is

0:41:00.320 --> 0:41:03.520
<v Speaker 1>the it is the female that lives longer, certainly in humans,

0:41:04.200 --> 0:41:08.400
<v Speaker 1>though that may be more pronounced in cases where we

0:41:08.480 --> 0:41:11.640
<v Speaker 1>have been removed from the like when we've got modern

0:41:11.680 --> 0:41:14.480
<v Speaker 1>medical care, because, for example, there is a lot of

0:41:14.600 --> 0:41:21.160
<v Speaker 1>natural mortality during childbearing. So I don't know, you can

0:41:21.239 --> 0:41:23.719
<v Speaker 1>maybe a point for Aristotle, there maybe a point for

0:41:24.520 --> 0:41:28.719
<v Speaker 1>modern science. We'll see, um. But anyway, that's that's that's

0:41:28.719 --> 0:41:31.080
<v Speaker 1>what Aristotle had to say in the matter. And uh,

0:41:31.440 --> 0:41:34.520
<v Speaker 1>and I like, I say, it's it's it's fascinating to

0:41:34.560 --> 0:41:36.520
<v Speaker 1>look back on his writings and see how he's working

0:41:36.520 --> 0:41:39.160
<v Speaker 1>this all out totally. So in the end, I think

0:41:39.200 --> 0:41:44.359
<v Speaker 1>we're still left with this biological paradox of aging. Once

0:41:44.440 --> 0:41:47.239
<v Speaker 1>we think about aging in a biological context, it's sort

0:41:47.280 --> 0:41:51.600
<v Speaker 1>of fails to make sense. Evolution selects for genes that

0:41:51.800 --> 0:41:55.920
<v Speaker 1>increase biological fitness, meaning that increase the chances of survival

0:41:56.040 --> 0:42:00.360
<v Speaker 1>and reproduction. Aging is characterized by an organ is m

0:42:00.440 --> 0:42:05.319
<v Speaker 1>level decline in the chances of survival and reproduction. So

0:42:05.560 --> 0:42:08.680
<v Speaker 1>why would organisms that have been evolving for billions of

0:42:08.760 --> 0:42:13.680
<v Speaker 1>years still age, deteriorate, lose the ability to reproduce and

0:42:13.719 --> 0:42:18.480
<v Speaker 1>eventually die. Shouldn't we have evolved to maximize survival and

0:42:18.520 --> 0:42:22.759
<v Speaker 1>reproduction as long as possible. Shouldn't we survive and keep

0:42:22.880 --> 0:42:25.840
<v Speaker 1>making babies until a leopard bites our head off? But

0:42:25.880 --> 0:42:28.480
<v Speaker 1>obviously this is not how things are. So what's the

0:42:28.520 --> 0:42:32.320
<v Speaker 1>answer to this mystery? We'll explore that in the next episode.

0:42:32.360 --> 0:42:35.560
<v Speaker 1>That's right, we have a cliffhanger. Will it be cruel

0:42:35.600 --> 0:42:40.600
<v Speaker 1>twist of fate? Accident? Uh? Biological mechanism that serves a purpose?

0:42:41.320 --> 0:42:43.960
<v Speaker 1>I don't know. We'll find out maybe our genome has

0:42:44.000 --> 0:42:48.840
<v Speaker 1>been evolving to feed leopards all right. Well, in the meantime,

0:42:48.840 --> 0:42:51.040
<v Speaker 1>while you're waiting for that next episode, head on over

0:42:51.040 --> 0:42:52.960
<v Speaker 1>to Stuff to Blow your Mind dot com. That's the

0:42:53.000 --> 0:42:55.800
<v Speaker 1>mother ship. That's where you'll find all the podcast episodes.

0:42:55.840 --> 0:42:59.440
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0:43:03.719 --> 0:43:07.000
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0:43:08.719 --> 0:43:11.120
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0:43:11.160 --> 0:43:14.399
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0:43:27.440 --> 0:43:52.600
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