1 00:00:00,280 --> 00:00:02,920 Speaker 1: Brought to you by the reinvented two thousand twelve Camray. 2 00:00:03,160 --> 00:00:07,600 Speaker 1: It's ready. Are you welcome to Stuff you should know 3 00:00:08,200 --> 00:00:11,520 Speaker 1: from house Stuff Works dot Com. Hey, and welcome to 4 00:00:11,520 --> 00:00:15,720 Speaker 1: the podcast. I'm Josh Clark. There's Chuck Bryant. I gotta 5 00:00:15,760 --> 00:00:18,000 Speaker 1: come up with something new, Chuck. Now you say there's 6 00:00:18,079 --> 00:00:22,959 Speaker 1: like there, it goes like I run by the Ah, yeah, 7 00:00:23,000 --> 00:00:26,880 Speaker 1: we'll figure this out. Maybe when we're not recording, we'll 8 00:00:26,920 --> 00:00:28,880 Speaker 1: just take the extra effort. That means we'll have to 9 00:00:28,920 --> 00:00:31,960 Speaker 1: speak outside of this room. Now, Yeah, we don't do that. 10 00:00:32,000 --> 00:00:35,000 Speaker 1: We're like Pete Townsend and Roger Daltery they do that, 11 00:00:35,159 --> 00:00:38,360 Speaker 1: or like the Gallagher brothers from Oasis. Yeah, they hate 12 00:00:38,360 --> 00:00:41,240 Speaker 1: each other, but when they get together it's like your gold. 13 00:00:41,320 --> 00:00:45,080 Speaker 1: You know, it's magic man. So, Chuck, have you ever 14 00:00:45,120 --> 00:00:48,760 Speaker 1: seen then John wou movie Face Off? I have not 15 00:00:49,080 --> 00:00:52,360 Speaker 1: good Chuck. You want to talk about face transplants? Yes, 16 00:00:52,520 --> 00:00:54,760 Speaker 1: you remember Travis the Chimp. It was like my first 17 00:00:54,880 --> 00:00:58,240 Speaker 1: blog post ever. Ah yeah, yeah, that chimp that went 18 00:00:58,320 --> 00:01:01,800 Speaker 1: crazy and Hampshire. Yeah, well apparently he tore that woman's 19 00:01:01,840 --> 00:01:05,520 Speaker 1: face off. Yeah. There There was a transcript of the 20 00:01:05,600 --> 00:01:08,279 Speaker 1: of the nine eleven call and one of the cops 21 00:01:08,360 --> 00:01:10,240 Speaker 1: is like, you need to send an ambulance out here. 22 00:01:10,240 --> 00:01:12,880 Speaker 1: There's a man down. He is in trouble. The guy 23 00:01:12,880 --> 00:01:15,040 Speaker 1: couldn't even tell it was a woman, like her face 24 00:01:15,120 --> 00:01:19,479 Speaker 1: was pulled off. Um and uh. One of the things, 25 00:01:19,520 --> 00:01:21,600 Speaker 1: one of the first things I heard after the detail 26 00:01:21,680 --> 00:01:25,280 Speaker 1: at Grizzly Detail emerged was that this woman would likely 27 00:01:25,319 --> 00:01:28,120 Speaker 1: get a face transplant. Right. And I'd heard of him, 28 00:01:28,120 --> 00:01:32,280 Speaker 1: but vaguely, and hadn't really put much thought into a 29 00:01:32,319 --> 00:01:35,600 Speaker 1: face transplant, you know, I remember just from and we'll 30 00:01:35,600 --> 00:01:37,320 Speaker 1: talk about her later. But the French woman was the 31 00:01:37,640 --> 00:01:39,880 Speaker 1: one that came to mind. I hadn't heard about her. 32 00:01:39,959 --> 00:01:42,160 Speaker 1: I wasn't paying attention, I guess. And what two thousand five, 33 00:01:42,520 --> 00:01:45,280 Speaker 1: That was a rough year for you, it was, let 34 00:01:45,280 --> 00:01:49,560 Speaker 1: me think, pretty hazy. Huh, Holy cow, I lost two 35 00:01:49,600 --> 00:01:51,800 Speaker 1: thousand five. I'm gonna have to give some thought to 36 00:01:51,880 --> 00:01:55,760 Speaker 1: this while we're practicing new intros, right, okay, so um, 37 00:01:55,800 --> 00:01:57,920 Speaker 1: so yes, this this poor woman who was attacked by 38 00:01:57,960 --> 00:02:00,960 Speaker 1: this rampaging chimp, who was eventually shot to death by 39 00:02:00,960 --> 00:02:04,480 Speaker 1: the police. Um, we'll likely get a face transplant. And 40 00:02:04,480 --> 00:02:06,320 Speaker 1: we just so happened to have an article on the 41 00:02:06,360 --> 00:02:10,880 Speaker 1: site appropriately titled how face transplants work. And that's what 42 00:02:10,919 --> 00:02:13,240 Speaker 1: we're gonna talk about today, right. Yeah. I love this article. 43 00:02:13,280 --> 00:02:15,920 Speaker 1: By the way. It was gruesome. It was gruesome, but 44 00:02:15,960 --> 00:02:18,240 Speaker 1: it was really I don't know, Stephanie Watson wrote, it's 45 00:02:18,320 --> 00:02:21,679 Speaker 1: just really well written. It is well written. I agree wellheartedly. Um, 46 00:02:21,720 --> 00:02:24,840 Speaker 1: there's all sorts of pictures, um. And actually there's an 47 00:02:24,840 --> 00:02:29,360 Speaker 1: illustration like that I did too. Yeah. Um, the faces 48 00:02:29,440 --> 00:02:32,000 Speaker 1: kind of draped over the skull. I like the face 49 00:02:32,040 --> 00:02:35,040 Speaker 1: on ice. Yeah. Yeah, that was the best one. I think. 50 00:02:35,200 --> 00:02:37,480 Speaker 1: I wonder if Marcus did that one. We'll never know. 51 00:02:37,600 --> 00:02:40,639 Speaker 1: We'll never know, no, so chuck um there. The first 52 00:02:40,960 --> 00:02:45,960 Speaker 1: successful transplant of any kind was what nineteen and there 53 00:02:46,000 --> 00:02:47,839 Speaker 1: was a physician I think he was in Boston named 54 00:02:47,880 --> 00:02:53,240 Speaker 1: Joseph Murray, and he carried out the first successful kidney transplant. 55 00:02:53,400 --> 00:02:56,160 Speaker 1: And he did it using identical twins, which was the 56 00:02:56,240 --> 00:03:00,320 Speaker 1: key early on, like people had tried transplanting things before. 57 00:03:00,520 --> 00:03:03,640 Speaker 1: But you know, in the transplant went well, but ultimately 58 00:03:03,680 --> 00:03:06,720 Speaker 1: the body rejected it. You know why, Uh, I want 59 00:03:06,720 --> 00:03:10,680 Speaker 1: to hear your explanation, pal, Well, it's because the body 60 00:03:10,880 --> 00:03:14,360 Speaker 1: isn't very receptive to foreign tissue. So when you get 61 00:03:14,600 --> 00:03:17,120 Speaker 1: we're back in those days when you would get something transplanted. 62 00:03:17,520 --> 00:03:19,520 Speaker 1: Your body sees that as a foreign invader, just like 63 00:03:19,560 --> 00:03:22,480 Speaker 1: it would a disease or something, and the white blood 64 00:03:22,480 --> 00:03:25,519 Speaker 1: cells kick into gear and just go into attack mode. 65 00:03:25,639 --> 00:03:28,440 Speaker 1: The body no likely foreign invaders now, But if you're 66 00:03:28,480 --> 00:03:30,840 Speaker 1: identical twins, um, you had enough of a match to 67 00:03:30,840 --> 00:03:32,919 Speaker 1: where it worked out. Right. The problem is that most 68 00:03:32,919 --> 00:03:36,400 Speaker 1: people who need transplants don't have identical twins, so it's 69 00:03:36,440 --> 00:03:39,800 Speaker 1: a it's a terrible way to you know, establish medical procedure, 70 00:03:39,920 --> 00:03:41,640 Speaker 1: but it was a good way to starting well sure, 71 00:03:41,720 --> 00:03:44,720 Speaker 1: and it was successful. He showed that you can transplant 72 00:03:44,800 --> 00:03:48,360 Speaker 1: human tissue from one person to another and it be successful. 73 00:03:48,560 --> 00:03:53,400 Speaker 1: So that was like the real milestone. Uh. And then 74 00:03:53,440 --> 00:03:56,080 Speaker 1: after that, you know, people started exploring other ways to 75 00:03:56,160 --> 00:03:59,720 Speaker 1: do this without uh, you know, um, identical twins. You 76 00:03:59,760 --> 00:04:03,400 Speaker 1: know how I want to hear your explanation. Well, you're 77 00:04:03,400 --> 00:04:07,720 Speaker 1: really piping up today, aren't Uh. By the nineteen sixties, 78 00:04:07,760 --> 00:04:09,760 Speaker 1: what they figured out is that they could suppress your 79 00:04:09,800 --> 00:04:14,640 Speaker 1: immune system. Then you could using drugs like a cyclosporine, 80 00:04:14,720 --> 00:04:17,279 Speaker 1: you could you could be successful with the transplant. And 81 00:04:17,320 --> 00:04:19,480 Speaker 1: what they're trying to suppress their things called and egens, 82 00:04:19,520 --> 00:04:25,080 Speaker 1: which are proteins. They're found on the exterior of uh 83 00:04:25,200 --> 00:04:29,400 Speaker 1: tissue tissue cells, right yeah, um, and and those are 84 00:04:29,400 --> 00:04:32,200 Speaker 1: the things that create that prompt an immune response. So 85 00:04:32,279 --> 00:04:34,600 Speaker 1: they're the ones that sense like, well, whoa, whoa, I 86 00:04:34,640 --> 00:04:37,440 Speaker 1: don't remember this hand being here before we lost our hand. 87 00:04:37,520 --> 00:04:40,640 Speaker 1: What's going on here? Go get rid of that hand, right, 88 00:04:40,920 --> 00:04:43,240 Speaker 1: And then the white blood cells attack like the cavalry, 89 00:04:43,480 --> 00:04:45,120 Speaker 1: which is awesome. I mean, it's great. It's cool that 90 00:04:45,160 --> 00:04:47,520 Speaker 1: your body does this because that means you have a 91 00:04:47,640 --> 00:04:52,120 Speaker 1: robust and violent immune system. Of course, if you're trying 92 00:04:52,120 --> 00:04:54,360 Speaker 1: to get a transplant, it's no good. But you want 93 00:04:54,360 --> 00:04:56,640 Speaker 1: your body to go after things with bigger like yeah, 94 00:04:56,680 --> 00:04:59,960 Speaker 1: like mersa, you don't want that, no, no, but yeah, 95 00:05:00,040 --> 00:05:02,080 Speaker 1: if you have a hand, you you you wish you 96 00:05:02,080 --> 00:05:05,640 Speaker 1: could tell your your antigens to just settle down. It's 97 00:05:05,680 --> 00:05:08,279 Speaker 1: your new hand and you're pretty fond of it to 98 00:05:08,360 --> 00:05:11,040 Speaker 1: keep it right. So, so the problem is the the 99 00:05:11,120 --> 00:05:16,320 Speaker 1: drugs that they came up with were immune suppressive, meaning 100 00:05:16,720 --> 00:05:19,680 Speaker 1: okay that the antigens are no longer being prompted to 101 00:05:19,720 --> 00:05:22,480 Speaker 1: attack the hand or send the white bloods also attack 102 00:05:22,520 --> 00:05:24,640 Speaker 1: the hand, but they're also not being prompted to go 103 00:05:24,800 --> 00:05:29,120 Speaker 1: attack the mersa bacteria that's in your body. Now, Um, 104 00:05:29,400 --> 00:05:32,640 Speaker 1: you left you susceptible to other problems that pretty much 105 00:05:32,640 --> 00:05:36,280 Speaker 1: everything else. I mean, how many uh, bacteria and viruses 106 00:05:36,440 --> 00:05:38,720 Speaker 1: just germs in general do we come in contact with 107 00:05:38,760 --> 00:05:42,520 Speaker 1: any every day and we don't even notice? Like we 108 00:05:42,880 --> 00:05:45,640 Speaker 1: did that one on toads causing wards and like twenty 109 00:05:45,640 --> 00:05:50,279 Speaker 1: million people have the human pablova virus and um, you know, 110 00:05:51,360 --> 00:05:54,359 Speaker 1: very few are actually suffering from it. We don't even 111 00:05:54,400 --> 00:05:57,560 Speaker 1: know where carriers because their bodies can ward it off, right, 112 00:05:57,600 --> 00:05:59,360 Speaker 1: So we had to come up with something better, and 113 00:05:59,400 --> 00:06:03,480 Speaker 1: they did, but it was along the lines of immunosuppressive drugs. 114 00:06:04,160 --> 00:06:07,240 Speaker 1: We just got the most slightly more refined, right Exactly. 115 00:06:07,360 --> 00:06:09,800 Speaker 1: Once we had that down, we started really going crazy 116 00:06:09,880 --> 00:06:14,360 Speaker 1: with heart transplants transplants. Eighties and nineties is when they 117 00:06:14,400 --> 00:06:16,760 Speaker 1: really kind of started mastering this whole technique, right, And 118 00:06:16,800 --> 00:06:19,839 Speaker 1: then after that, after the vital organ transplants, we started 119 00:06:19,880 --> 00:06:22,719 Speaker 1: getting into those hand transplants. I gotta tell you, I 120 00:06:22,720 --> 00:06:26,120 Speaker 1: find that fascinating. Very Look, Skywalker, S know you're gonna 121 00:06:26,160 --> 00:06:28,120 Speaker 1: say that, thank you. You know me so well, well, 122 00:06:28,120 --> 00:06:29,680 Speaker 1: the way you're doing your hand, it was like the 123 00:06:29,720 --> 00:06:33,000 Speaker 1: scene from the movie. Yeah, it looks like it. Oh yeah, 124 00:06:33,040 --> 00:06:38,760 Speaker 1: they can't see okay. Um. So, so inevitably we end 125 00:06:38,880 --> 00:06:42,080 Speaker 1: up at facial transplants and it took a little while, 126 00:06:42,120 --> 00:06:44,640 Speaker 1: but really, if you think about it, we went from 127 00:06:44,760 --> 00:06:47,960 Speaker 1: the first successful kidney transplant to the first successful face 128 00:06:48,040 --> 00:06:51,799 Speaker 1: transplant about fifty years. Not bad. That's pretty quick. Yeah. Yeah, 129 00:06:51,920 --> 00:06:53,719 Speaker 1: So so let's talk about you want to talk about 130 00:06:53,720 --> 00:07:00,440 Speaker 1: that poor girl in uh sound deep coo are or Josh. 131 00:07:00,440 --> 00:07:02,520 Speaker 1: She was nine years old in northern Indian. She was 132 00:07:02,600 --> 00:07:05,920 Speaker 1: chopping grass to feed her buffalo, her family buffalo, which 133 00:07:05,960 --> 00:07:09,600 Speaker 1: is a noble pursuit very much, and her hair got 134 00:07:09,640 --> 00:07:13,720 Speaker 1: caught in the threshing machine and basically pulled her entire 135 00:07:13,760 --> 00:07:16,800 Speaker 1: face and scalp and hair right off of her, clean 136 00:07:16,840 --> 00:07:20,320 Speaker 1: off of her. Yeah, and and her family reacted promptly. 137 00:07:20,720 --> 00:07:23,760 Speaker 1: They threw her face into a bag, put the girl 138 00:07:23,800 --> 00:07:26,080 Speaker 1: on the back of a moped and drove to the 139 00:07:26,120 --> 00:07:29,760 Speaker 1: closest hospital, which was three hours away. So they drove 140 00:07:29,760 --> 00:07:34,200 Speaker 1: their faceless, scalpless, hairless daughter to the hospital on a 141 00:07:34,280 --> 00:07:38,240 Speaker 1: moped for three hours, and the doctors took a look 142 00:07:38,240 --> 00:07:40,000 Speaker 1: at her and we're like, we can't do skin grass. 143 00:07:40,000 --> 00:07:42,240 Speaker 1: This girl is never going to function properly again. So 144 00:07:42,280 --> 00:07:44,920 Speaker 1: they actually put her face, scalp and hair back on 145 00:07:45,840 --> 00:07:48,360 Speaker 1: and she she's functioning. Yeah. Actually, just I saw a 146 00:07:48,360 --> 00:07:52,400 Speaker 1: picture of her at nineteen on the internet. She looks good, 147 00:07:52,440 --> 00:07:55,320 Speaker 1: you know. I mean, there's some scars, obviously, and I 148 00:07:55,360 --> 00:07:57,560 Speaker 1: think her right eye has a little bit of a 149 00:07:57,680 --> 00:07:59,360 Speaker 1: droop to it, so, I mean you can tell, but 150 00:07:59,560 --> 00:08:01,920 Speaker 1: you know, if your face has been pulled clean off 151 00:08:01,920 --> 00:08:05,000 Speaker 1: by a treasure, you really can't complain about the little droopy. 152 00:08:05,120 --> 00:08:09,960 Speaker 1: I so that that was technically the first facial transplant, 153 00:08:10,200 --> 00:08:15,040 Speaker 1: but the first real transplant from a donor came in 154 00:08:15,080 --> 00:08:17,960 Speaker 1: two thousand five. Can I handle the grizzly details on 155 00:08:18,000 --> 00:08:21,160 Speaker 1: this one please. There's something that I noticed in researching 156 00:08:21,320 --> 00:08:24,760 Speaker 1: how face transplants work, and that is that all face 157 00:08:24,800 --> 00:08:28,840 Speaker 1: transplants begin with a horrible, gruesome event. Yeah, there's really 158 00:08:28,880 --> 00:08:32,200 Speaker 1: no way to lose your face unless there's some horrible accident. 159 00:08:32,320 --> 00:08:34,959 Speaker 1: And even if there's like a disease, it's a ravaging, 160 00:08:34,960 --> 00:08:39,080 Speaker 1: horrible disease to like tumors or something, or the well, 161 00:08:39,080 --> 00:08:40,640 Speaker 1: the elephant man disease. I think it is what they 162 00:08:40,640 --> 00:08:44,040 Speaker 1: call it. Yes, he was not an animal, no um. 163 00:08:44,240 --> 00:08:49,000 Speaker 1: So this woman was named Isabelle Dean Noir and uh, 164 00:08:49,280 --> 00:08:52,240 Speaker 1: she's a frenchwoman. And in two thousand five, she popped 165 00:08:52,240 --> 00:08:55,960 Speaker 1: some sleeping pills, passed out on her couch and she 166 00:08:56,000 --> 00:08:58,079 Speaker 1: woke up. I don't know if this is a normal 167 00:08:58,120 --> 00:09:01,320 Speaker 1: habit of hers or not, but she woke up, and uh, 168 00:09:01,400 --> 00:09:03,560 Speaker 1: I went to go light a cigarette and found that 169 00:09:03,559 --> 00:09:05,880 Speaker 1: it kept falling out of her mouth. She didn't know 170 00:09:05,920 --> 00:09:07,800 Speaker 1: what was going on. So she goes to the mirror 171 00:09:08,200 --> 00:09:10,400 Speaker 1: and the lower half of her face I took from 172 00:09:10,400 --> 00:09:13,680 Speaker 1: below her nose down was gone. She was nothing but 173 00:09:13,800 --> 00:09:18,880 Speaker 1: like tissue and teeth. And apparently, from what I understand, 174 00:09:18,960 --> 00:09:20,679 Speaker 1: and I know you know something different, I'd like to 175 00:09:20,720 --> 00:09:23,800 Speaker 1: hear it. From what I understand, her black lab chewed 176 00:09:23,840 --> 00:09:27,040 Speaker 1: the bottom of her face off while she was sleeping. True. 177 00:09:27,720 --> 00:09:30,360 Speaker 1: Is that true? It is true, But there's and I 178 00:09:30,520 --> 00:09:32,520 Speaker 1: couldn't get a straight answer. I read a bunch of 179 00:09:32,600 --> 00:09:35,840 Speaker 1: articles and follow up articles on this today and I 180 00:09:35,920 --> 00:09:39,160 Speaker 1: still didn't get what I think is the absolute truth 181 00:09:39,160 --> 00:09:42,880 Speaker 1: of what happened. Some people um claimed she was committing suicide, 182 00:09:43,240 --> 00:09:45,560 Speaker 1: and then the doctors denied it, but then one doctor 183 00:09:45,600 --> 00:09:49,400 Speaker 1: said that she had tried to commit suicide. And um, 184 00:09:49,640 --> 00:09:53,320 Speaker 1: then the the whole dog situation. You know, black labs, 185 00:09:53,320 --> 00:09:55,720 Speaker 1: I mean, you're a dog guy. They aren't to believe 186 00:09:55,760 --> 00:09:58,240 Speaker 1: that a lab would do that, right, So what they 187 00:09:58,280 --> 00:10:01,120 Speaker 1: think might have happened was she was out and the 188 00:10:01,200 --> 00:10:04,840 Speaker 1: dog was concerned because they thought she was dead, and 189 00:10:05,000 --> 00:10:08,360 Speaker 1: was pawing at her face and became really agitated and 190 00:10:08,440 --> 00:10:12,040 Speaker 1: upset and pawed and scratched to the point where you know, 191 00:10:12,080 --> 00:10:15,720 Speaker 1: there was blood probably, and then started chewing up like 192 00:10:16,320 --> 00:10:18,560 Speaker 1: trying to evidently trying to wake her up. But there's 193 00:10:18,600 --> 00:10:21,720 Speaker 1: speculation about that too. But they but they think the 194 00:10:21,760 --> 00:10:24,079 Speaker 1: dog did do it for some reason or another. They 195 00:10:24,080 --> 00:10:26,040 Speaker 1: think the dog did it for a reason, trying to 196 00:10:26,080 --> 00:10:30,280 Speaker 1: arouse her from her slumber. Um, because I think I 197 00:10:30,320 --> 00:10:33,040 Speaker 1: read someone else said that you'd have to be so 198 00:10:33,120 --> 00:10:35,520 Speaker 1: far out of it to not wake up with that 199 00:10:35,600 --> 00:10:38,280 Speaker 1: kind of pain sensation that it had to have been 200 00:10:38,320 --> 00:10:41,080 Speaker 1: a suicide attempt. So I thought it was a little 201 00:10:41,080 --> 00:10:43,600 Speaker 1: odd that she took pills and fell asleep on the couch, right, 202 00:10:43,760 --> 00:10:45,719 Speaker 1: I mean, yeah, And then she came out later and 203 00:10:45,720 --> 00:10:47,560 Speaker 1: said that she hit her head and was knocked out, 204 00:10:47,600 --> 00:10:49,920 Speaker 1: so I'm not exactly sure what happened. All I know 205 00:10:50,000 --> 00:10:51,800 Speaker 1: is the dog was put to sleep, which really is 206 00:10:51,880 --> 00:10:54,320 Speaker 1: upsetting to me. That is upsetting, especially if it was 207 00:10:54,360 --> 00:10:57,360 Speaker 1: trying to rescue her. I mean, the whole thing is upsetting. 208 00:10:57,520 --> 00:11:02,120 Speaker 1: Regardless of what happened. Isabel Dean Noir got a face transplant. 209 00:11:02,720 --> 00:11:06,760 Speaker 1: She did. Indeed, h this is the first major news 210 00:11:07,120 --> 00:11:10,760 Speaker 1: uh worthy face transplant, which I still didn't hear about. 211 00:11:11,760 --> 00:11:15,000 Speaker 1: That was a rough here for you. Um so uh. 212 00:11:15,400 --> 00:11:18,320 Speaker 1: Apparently they could have taken tissue from her chest to 213 00:11:18,400 --> 00:11:22,760 Speaker 1: repair the damage, but she wouldn't have had very much movement, right, 214 00:11:22,800 --> 00:11:25,160 Speaker 1: It would have just looked like a face, but not 215 00:11:25,240 --> 00:11:27,679 Speaker 1: really exactly a fake eye or something. Right. But they 216 00:11:27,800 --> 00:11:31,120 Speaker 1: what they want is feeling and function going on. They 217 00:11:31,120 --> 00:11:33,360 Speaker 1: wanted to be able to smell and feel and have 218 00:11:33,440 --> 00:11:36,520 Speaker 1: all the senses reacting, and that's the ideal. Most surgeons 219 00:11:36,520 --> 00:11:39,960 Speaker 1: are perfectionists. Yeah, So, so what they did was they 220 00:11:39,960 --> 00:11:44,480 Speaker 1: found a donor. Here's what we're getting to, the ethical aspects. 221 00:11:44,760 --> 00:11:47,840 Speaker 1: Can we jump ahead and move around a little bit please? Okay, 222 00:11:48,160 --> 00:11:52,480 Speaker 1: there's the only person who can be a face donor 223 00:11:53,160 --> 00:11:56,960 Speaker 1: is one who has to be on life support on 224 00:11:57,040 --> 00:12:00,040 Speaker 1: life support, Well, someone has to be alive, right, but 225 00:12:00,040 --> 00:12:02,800 Speaker 1: but you wouldn't give up your face? Sure, no, no 226 00:12:02,840 --> 00:12:05,280 Speaker 1: one's that. I just want to get specific. It has 227 00:12:05,400 --> 00:12:07,240 Speaker 1: it has to come from a live donor, and the 228 00:12:07,280 --> 00:12:09,280 Speaker 1: only scenario where that could happen is if you're brain 229 00:12:09,360 --> 00:12:11,240 Speaker 1: dead on life support and then the family has to 230 00:12:11,280 --> 00:12:14,800 Speaker 1: agree to pull the plug essentially, right, And remember we 231 00:12:14,840 --> 00:12:17,280 Speaker 1: did the how comas work and we were we were 232 00:12:17,600 --> 00:12:21,920 Speaker 1: positing whether or not people feel pain in deep vegetative states, 233 00:12:22,679 --> 00:12:25,480 Speaker 1: and you gotta hope not when they're taking your face, 234 00:12:25,520 --> 00:12:28,760 Speaker 1: because that's exactly what they do. They go to the donor, 235 00:12:28,880 --> 00:12:32,079 Speaker 1: they moved the donor into the operating theater, they take 236 00:12:32,520 --> 00:12:35,080 Speaker 1: the face off. I imagined they cut around the scalp 237 00:12:35,120 --> 00:12:37,439 Speaker 1: and then down behind the ears, maybe in front of 238 00:12:37,480 --> 00:12:40,959 Speaker 1: the ears, whatever, below the chin, and that would be 239 00:12:41,000 --> 00:12:45,120 Speaker 1: a full face transplant, as our illustration shows, they put 240 00:12:45,160 --> 00:12:47,760 Speaker 1: it on ice. Well, this was a partial face transplant, okay, 241 00:12:47,760 --> 00:12:49,480 Speaker 1: so it would have been like the lower part of 242 00:12:49,480 --> 00:12:51,679 Speaker 1: the face. But whatever part of the face you need, 243 00:12:51,679 --> 00:12:54,960 Speaker 1: whether it's full or partial, it would be cut off removed, 244 00:12:55,240 --> 00:12:57,600 Speaker 1: depending on whether or not any of the connective tissue 245 00:12:57,640 --> 00:13:02,800 Speaker 1: was needed. Still any bone, any fat muscles, all of 246 00:13:02,840 --> 00:13:06,080 Speaker 1: that stuff may be taken as well, and then it's 247 00:13:06,360 --> 00:13:09,520 Speaker 1: again put on ice or whatever, transported to wherever the 248 00:13:09,559 --> 00:13:12,520 Speaker 1: recipient is. And then all of these things are reattached. 249 00:13:12,559 --> 00:13:18,000 Speaker 1: Blood vessels are reattached, a connective tissue, all this stuff. Um, 250 00:13:18,200 --> 00:13:20,040 Speaker 1: and you have to do it in such a way. Well. 251 00:13:20,120 --> 00:13:23,160 Speaker 1: Number one, skin tones kind of a big, a big consideration. 252 00:13:23,240 --> 00:13:25,520 Speaker 1: To find a match. Um, you want to find somebody, 253 00:13:25,520 --> 00:13:27,600 Speaker 1: you have to do h l a testing or matching, 254 00:13:28,280 --> 00:13:30,679 Speaker 1: which is that antigen testing to make sure that that 255 00:13:30,760 --> 00:13:33,640 Speaker 1: you have a similar enough immune system that there won't 256 00:13:33,640 --> 00:13:36,640 Speaker 1: be a rejection. Um, you may have to put bone down, 257 00:13:36,920 --> 00:13:39,840 Speaker 1: as was the case with a Chinese guy in what 258 00:13:39,960 --> 00:13:44,400 Speaker 1: two thousand six and uh, he was malled by a bear? Right, 259 00:13:45,120 --> 00:13:47,720 Speaker 1: what what is going on? Right? He was malled by 260 00:13:47,720 --> 00:13:50,080 Speaker 1: a bear. And this was a unique case different from 261 00:13:50,440 --> 00:13:54,400 Speaker 1: the French woman because he was missing skin and part 262 00:13:54,400 --> 00:13:57,640 Speaker 1: of the bone in his nose and cheeks. He was 263 00:13:57,679 --> 00:14:01,280 Speaker 1: a huge challenge. Hers was just skin in and his 264 00:14:01,840 --> 00:14:06,200 Speaker 1: required quite a bit more. And we're talking like teams 265 00:14:06,200 --> 00:14:08,800 Speaker 1: of fifteen to twenty doctors over the course of fifteen 266 00:14:08,800 --> 00:14:12,880 Speaker 1: to twenty hours. Well with Madame de Noir. She had 267 00:14:12,920 --> 00:14:16,360 Speaker 1: a team of fifty doctors. They started at ten thirty 268 00:14:16,400 --> 00:14:18,559 Speaker 1: at night and they finished at four the next day, 269 00:14:18,600 --> 00:14:21,800 Speaker 1: four after four in the afternoon, went straight through the 270 00:14:21,880 --> 00:14:24,120 Speaker 1: irony is as if she did try to commit suicide. 271 00:14:24,320 --> 00:14:26,800 Speaker 1: Her face was donated by a woman who failed in 272 00:14:26,800 --> 00:14:29,440 Speaker 1: a suicide attach. Yeah, how about that. Yeah it's a 273 00:14:29,480 --> 00:14:33,280 Speaker 1: little odd, but yeah, okay. So they they also practice 274 00:14:34,480 --> 00:14:39,040 Speaker 1: the people of rats, cadavers, rabbits. There's a picture of 275 00:14:39,360 --> 00:14:42,280 Speaker 1: I guess one of their test subjects, a rabbit with 276 00:14:42,320 --> 00:14:45,680 Speaker 1: a face transplant on page zero, the first page of 277 00:14:45,720 --> 00:14:49,080 Speaker 1: this article, and it's just cute as a button. But 278 00:14:49,160 --> 00:14:52,400 Speaker 1: it's also furry. We don't have the luxury of fur 279 00:14:52,640 --> 00:14:55,400 Speaker 1: as humans, so they kind of have to do a 280 00:14:55,440 --> 00:14:58,960 Speaker 1: relatively good job reconstructing a face, and it usually takes 281 00:14:59,000 --> 00:15:02,840 Speaker 1: more than once. They'll be several phases of surgery. Yeah, 282 00:15:02,840 --> 00:15:05,440 Speaker 1: it shows, uh, And I've seen pictures of the frenchwoman 283 00:15:05,520 --> 00:15:08,680 Speaker 1: over the course of different surgeries, getting better and better. Um. 284 00:15:08,720 --> 00:15:10,920 Speaker 1: What I thought was interesting was that once you have 285 00:15:11,040 --> 00:15:14,000 Speaker 1: the surgery, you need to be on these immuno suppressant 286 00:15:14,040 --> 00:15:17,600 Speaker 1: drugs for the rest of your life. So it's it's 287 00:15:17,640 --> 00:15:19,160 Speaker 1: good that you're able to live through this and get 288 00:15:19,160 --> 00:15:21,520 Speaker 1: a new face. But these drugs also put a serious 289 00:15:21,600 --> 00:15:24,880 Speaker 1: DNT and your ability to survive and live a long 290 00:15:24,920 --> 00:15:28,720 Speaker 1: life right, And apparently Madame de Noir is not really 291 00:15:28,760 --> 00:15:31,520 Speaker 1: helping things along. She refuses to quit smoking, and I 292 00:15:31,560 --> 00:15:33,720 Speaker 1: thought you might respect that, and the doctors are like, 293 00:15:34,160 --> 00:15:37,560 Speaker 1: come on, she smoked pretty soon afterward too. Yeah. Well, 294 00:15:37,600 --> 00:15:39,320 Speaker 1: I mean, if you're a smoker, you're a smoker, dude, 295 00:15:39,320 --> 00:15:41,880 Speaker 1: face transplant or no, I guess. So. Yeah, my first 296 00:15:41,920 --> 00:15:44,640 Speaker 1: father in law got like shunts put in. He was 297 00:15:44,680 --> 00:15:47,480 Speaker 1: smoking and golfing like a couple of days later. Really, 298 00:15:47,520 --> 00:15:51,240 Speaker 1: he just wouldn't stop heart shunts. I should say, okay, 299 00:15:51,280 --> 00:15:54,960 Speaker 1: cardiac shunts. Um. Now, Josh, these are all partial transplants, 300 00:15:55,360 --> 00:15:57,120 Speaker 1: even in the case of the one from China, and 301 00:15:57,160 --> 00:15:59,160 Speaker 1: as of the writing of this article, we actually need 302 00:15:59,200 --> 00:16:02,200 Speaker 1: to update this article. There were no full transplants, but 303 00:16:02,240 --> 00:16:04,400 Speaker 1: there have been since then. Chuck, I have to say 304 00:16:04,560 --> 00:16:08,720 Speaker 1: you were killing it today the external research. You corrected 305 00:16:08,720 --> 00:16:11,120 Speaker 1: me at least once, if not twice. I am proud 306 00:16:11,120 --> 00:16:16,160 Speaker 1: of Chuckers compass head hearts Chuckers um. So yes, Josh, 307 00:16:16,200 --> 00:16:19,000 Speaker 1: I'm ignoring your praise there have been two transplants that 308 00:16:19,200 --> 00:16:22,440 Speaker 1: I know of. There may be more, but I've noted 309 00:16:22,480 --> 00:16:25,640 Speaker 1: a couple that have happened that are full facial transplants. 310 00:16:25,680 --> 00:16:27,640 Speaker 1: One of them was a woman in Chicago who they 311 00:16:27,680 --> 00:16:31,760 Speaker 1: haven't named, keeping that quiet, who the doctor basically said 312 00:16:31,880 --> 00:16:34,440 Speaker 1: she didn't have a nose, she didn't have a midface 313 00:16:34,560 --> 00:16:37,960 Speaker 1: at all. And they were able to transplant Josh almost 314 00:16:38,000 --> 00:16:42,920 Speaker 1: eighty three square inches of skin with muscle bone, upper lip, 315 00:16:43,280 --> 00:16:47,560 Speaker 1: and nose from the donor still attached. Isn't that amazing? 316 00:16:48,400 --> 00:16:50,960 Speaker 1: And Uh, the Cleveland clinic is where all this is 317 00:16:51,000 --> 00:16:52,880 Speaker 1: going on. Man, if you need a face transplant, you 318 00:16:52,880 --> 00:16:55,280 Speaker 1: want to be in Cleveland. Uh. And then there was 319 00:16:55,320 --> 00:16:59,280 Speaker 1: a man, a Frenchman who had the elephant man disease. Yeah, 320 00:16:59,320 --> 00:17:04,280 Speaker 1: I see you have a sure there, kenseee wow played 321 00:17:04,320 --> 00:17:07,520 Speaker 1: a difference yea. And this was just um March of 322 00:17:07,560 --> 00:17:12,040 Speaker 1: two thousand and eight. He had a transplant and new lips, 323 00:17:12,119 --> 00:17:14,919 Speaker 1: new cheeks, new nose, new mouth. We should we should 324 00:17:15,160 --> 00:17:17,920 Speaker 1: publish this that that before and after photo and a blog. 325 00:17:17,920 --> 00:17:20,120 Speaker 1: After the blog, this podcast comes out. What do you think? Yeah, 326 00:17:20,200 --> 00:17:23,520 Speaker 1: let me look and see if we can get right. Yeah, 327 00:17:23,560 --> 00:17:26,680 Speaker 1: I think we can. But yeah, though, so apparently they 328 00:17:26,680 --> 00:17:30,400 Speaker 1: can do full facial transplants now, it's it's an amazing 329 00:17:30,400 --> 00:17:33,560 Speaker 1: and amazing thing. Well, that brings up another ethical concern besides, 330 00:17:33,760 --> 00:17:35,880 Speaker 1: you know, taking the face of somebody who's not dead 331 00:17:35,920 --> 00:17:40,720 Speaker 1: but his brain dead. Um. The other ethical concerned that 332 00:17:40,720 --> 00:17:44,159 Speaker 1: that some parts of the medical community worry about is 333 00:17:44,680 --> 00:17:47,199 Speaker 1: what happens when the wealthy are like, you know, I 334 00:17:47,240 --> 00:17:50,399 Speaker 1: don't want collagen or botox. I'm just gonna get a 335 00:17:50,400 --> 00:17:53,480 Speaker 1: facial transplant from a poor, brain dead person. You know, 336 00:17:53,520 --> 00:17:56,560 Speaker 1: I'll pay the family like dollars and take the face. 337 00:17:58,080 --> 00:18:00,679 Speaker 1: I saw that in the article and don't buy it 338 00:18:00,760 --> 00:18:04,560 Speaker 1: because right now, like, they do a good job with 339 00:18:04,600 --> 00:18:09,000 Speaker 1: these transplants, but the end results certainly doesn't. You know. 340 00:18:09,080 --> 00:18:11,359 Speaker 1: If you're like, if your aim is to be extremely 341 00:18:11,400 --> 00:18:14,239 Speaker 1: handsome or beautiful, that's not what you're gonna get right 342 00:18:14,240 --> 00:18:16,560 Speaker 1: now with a face right now. Sure, but again, Chuck, 343 00:18:16,600 --> 00:18:19,480 Speaker 1: we went from the first kidney transplant to face transplants 344 00:18:19,480 --> 00:18:21,520 Speaker 1: in fifty years. Where are we going to be fifty 345 00:18:21,600 --> 00:18:24,800 Speaker 1: years from now? And I mean, really, is there anything 346 00:18:24,800 --> 00:18:28,880 Speaker 1: stopping vanity? No, there's not. And it's especially especially if 347 00:18:29,000 --> 00:18:33,679 Speaker 1: we harness um genetics so that we can age right, 348 00:18:33,800 --> 00:18:37,280 Speaker 1: we can we we we harness longevity, um, but we 349 00:18:37,440 --> 00:18:39,840 Speaker 1: still kind of age poorly. You don't think that people 350 00:18:39,880 --> 00:18:41,720 Speaker 1: are going to pay for a face transplant by e 351 00:18:41,840 --> 00:18:43,800 Speaker 1: D if we're living to like one twenty on average. 352 00:18:43,920 --> 00:18:46,359 Speaker 1: What I think will happen by in fifty years is 353 00:18:46,359 --> 00:18:49,199 Speaker 1: there will be other ways to make yourself beautiful. Like 354 00:18:49,200 --> 00:18:51,199 Speaker 1: you said, to stop the aging process, there will be 355 00:18:51,240 --> 00:18:54,960 Speaker 1: other ways besides uh, finding a beautiful brain dead person 356 00:18:55,480 --> 00:18:57,879 Speaker 1: to take their face. I think that's just that's just me. 357 00:18:58,000 --> 00:19:00,959 Speaker 1: We'll see, of course, you know, learning I'll be long gone. 358 00:19:01,800 --> 00:19:04,040 Speaker 1: Both of us will check. Yeah, I think I'm going 359 00:19:04,119 --> 00:19:07,959 Speaker 1: first too. Don't make your face no, And actually, let 360 00:19:07,960 --> 00:19:10,640 Speaker 1: me also say this. This is such a tangential aside. 361 00:19:11,080 --> 00:19:14,000 Speaker 1: Did you know that if you are an organ donor, 362 00:19:14,920 --> 00:19:17,040 Speaker 1: you should and you have a problem with your head 363 00:19:17,080 --> 00:19:21,320 Speaker 1: being used for cosmetic surgery practice, you have to specify 364 00:19:21,480 --> 00:19:25,080 Speaker 1: I do not want my head use for cosmetic surgery practice. Yeah, 365 00:19:25,320 --> 00:19:29,320 Speaker 1: because they if you go into a med school that 366 00:19:29,400 --> 00:19:33,399 Speaker 1: focuses on cosmetic surgery heads and they practice on you 367 00:19:33,480 --> 00:19:38,199 Speaker 1: doing faceless and stuff. Interesting. Yeah, so organ donor, and 368 00:19:38,240 --> 00:19:40,480 Speaker 1: actually I need to make that little caveat there, like, 369 00:19:40,560 --> 00:19:44,080 Speaker 1: do not use my face, it's too pretty. I wonder 370 00:19:44,160 --> 00:19:46,679 Speaker 1: if I noted that you can use my face, but 371 00:19:46,760 --> 00:19:49,440 Speaker 1: let me wear my flat cap. That would be cool. Yeah, 372 00:19:49,560 --> 00:19:51,680 Speaker 1: it would like your tongue hanging out in one eye 373 00:19:51,680 --> 00:19:55,040 Speaker 1: open still but your flat caps on cool to the end. Nice. So, 374 00:19:55,119 --> 00:19:56,760 Speaker 1: of course, the best thing you could do is learned 375 00:19:56,760 --> 00:19:58,479 Speaker 1: to be pretty on the inside, and then you wouldn't 376 00:19:58,480 --> 00:20:00,560 Speaker 1: have to worry about anything unless you're all. Buy a bear, 377 00:20:00,680 --> 00:20:02,600 Speaker 1: your black live, choose the bottom of your face off. 378 00:20:02,640 --> 00:20:05,800 Speaker 1: Then you get a pass for the face transplant thing. 379 00:20:05,880 --> 00:20:07,360 Speaker 1: You want to learn more about that. It's a really 380 00:20:07,440 --> 00:20:10,639 Speaker 1: cool article. You can type how face transplants work into 381 00:20:10,640 --> 00:20:13,720 Speaker 1: the handy search bar and how stuff works dot com? 382 00:20:13,800 --> 00:20:18,160 Speaker 1: And are we still doing plug fest? Alright? Our producer 383 00:20:18,280 --> 00:20:21,200 Speaker 1: Jerry says yes, So let's do it, Chuck. Let's start 384 00:20:21,240 --> 00:20:26,480 Speaker 1: with the blog abbreviated version. Yes, blog good, blog fun 385 00:20:27,320 --> 00:20:32,280 Speaker 1: Josh Chuck Right, blog fans read blog fire bad? All right? 386 00:20:32,520 --> 00:20:35,960 Speaker 1: Moving on, Okay, the stuff you should know super Stuff 387 00:20:35,960 --> 00:20:41,000 Speaker 1: Guide to the Economy that's on iTunes, worth the money 388 00:20:41,440 --> 00:20:45,840 Speaker 1: getting good feedback. Type in super stuffed on the search 389 00:20:45,880 --> 00:20:48,879 Speaker 1: bar on iTunes and you can get it all right, 390 00:20:49,000 --> 00:20:51,240 Speaker 1: plug fest is over, Okay, so then it's time for 391 00:20:51,359 --> 00:20:56,520 Speaker 1: reader mail. And uh, I see that that podcast finally 392 00:20:56,560 --> 00:20:59,320 Speaker 1: came out where we said hi Ku is dead once 393 00:20:59,320 --> 00:21:02,080 Speaker 1: and for all. Yeah, yeah, that was great. It's interesting 394 00:21:02,119 --> 00:21:05,280 Speaker 1: we still have some people writing in that are upset 395 00:21:05,280 --> 00:21:07,800 Speaker 1: about the lack of hikus, and then um many others 396 00:21:07,840 --> 00:21:10,199 Speaker 1: writing in saying thank you because I was tired of 397 00:21:10,240 --> 00:21:12,160 Speaker 1: it as well. Well. In case anyone didn't get the memo, 398 00:21:12,240 --> 00:21:15,000 Speaker 1: let's play that little clip from that that listener mail 399 00:21:15,040 --> 00:21:17,480 Speaker 1: where we do say that hi Ku theaters dead. Here 400 00:21:17,520 --> 00:21:22,520 Speaker 1: it is right, Josh. This is significant because today is 401 00:21:22,560 --> 00:21:27,040 Speaker 1: the day where we retire Haiku Theater. Thank you. Did 402 00:21:27,080 --> 00:21:29,560 Speaker 1: everyone here that we are retiring Hiku Theater. We love 403 00:21:29,600 --> 00:21:31,199 Speaker 1: your high Kus and you can still send him if 404 00:21:31,240 --> 00:21:33,360 Speaker 1: you want, but we're not going to read him anymore. Agreed. 405 00:21:33,520 --> 00:21:39,000 Speaker 1: Thank you, Chuck, Thank you, Thank you Chuck. So as 406 00:21:39,040 --> 00:21:42,520 Speaker 1: you can see, I'm not lying, Hiku Theater is clearly dead. 407 00:21:42,640 --> 00:21:45,639 Speaker 1: I don't see any reason for anybody sending Hiku. But 408 00:21:45,720 --> 00:21:48,400 Speaker 1: what is not dead, Josh, are mistakes that we occasionally 409 00:21:48,440 --> 00:21:51,119 Speaker 1: make that will never will never die. And we got 410 00:21:51,160 --> 00:21:53,840 Speaker 1: a correction, um from one we just did on the 411 00:21:53,880 --> 00:21:56,240 Speaker 1: World ending in twelve and this is a good one, 412 00:21:56,280 --> 00:21:57,760 Speaker 1: and I'd like to read the good ones. Yeah, the 413 00:21:57,760 --> 00:22:01,240 Speaker 1: good science one. Um. I just wanted to make a 414 00:22:01,280 --> 00:22:04,359 Speaker 1: small correction. You mentioned that the lava flows can be 415 00:22:04,480 --> 00:22:07,479 Speaker 1: used to determine the direction of magnetic north in the past, 416 00:22:07,800 --> 00:22:10,159 Speaker 1: which is true, but it is not because the lava 417 00:22:10,200 --> 00:22:13,560 Speaker 1: actually flows toward the pole. So evidently, Josh, there are 418 00:22:13,640 --> 00:22:17,080 Speaker 1: magnetic properties of some of the individual mineral grains. And 419 00:22:17,119 --> 00:22:19,320 Speaker 1: I know someone mentioned iron in one of their emails 420 00:22:19,760 --> 00:22:22,520 Speaker 1: inside the molten lava, and that becomes a line with 421 00:22:22,560 --> 00:22:24,879 Speaker 1: the direction of the pole. So when the lava cools 422 00:22:24,920 --> 00:22:28,080 Speaker 1: and hardens, that direction is locked in. So the lava 423 00:22:28,119 --> 00:22:30,919 Speaker 1: doesn't necessarily have to be flowing north, but the iron 424 00:22:30,920 --> 00:22:34,880 Speaker 1: particles and other minerals in there are pointed north. And 425 00:22:34,960 --> 00:22:38,520 Speaker 1: evidently you said the lava flows north, then that's not true, buddy. 426 00:22:38,920 --> 00:22:41,680 Speaker 1: So samples of the lava, if collected with care to 427 00:22:41,800 --> 00:22:44,040 Speaker 1: note the original orientation, can then be brought into the 428 00:22:44,119 --> 00:22:48,040 Speaker 1: lab and GEO referenced. And we get a big cheers 429 00:22:48,080 --> 00:22:52,320 Speaker 1: from Jessica for that one. And also Peter wrote in 430 00:22:52,359 --> 00:22:55,960 Speaker 1: about that, and John the Yellow Dart, thank you. John 431 00:22:56,000 --> 00:22:57,720 Speaker 1: the Yellow Darts and we're not allowed to say last 432 00:22:57,720 --> 00:23:00,399 Speaker 1: things anymore. That's why. If you're wondering gonna get in 433 00:23:00,440 --> 00:23:02,760 Speaker 1: trouble for the Yellow Dart, then no, that was it 434 00:23:02,840 --> 00:23:06,480 Speaker 1: was actually John the Yellow Dart blank. Oh got you? Okay, 435 00:23:06,480 --> 00:23:09,960 Speaker 1: well thanks, can we say blank? Then sure, John the 436 00:23:10,000 --> 00:23:11,840 Speaker 1: Yellow Dark blank. So his last name is not blank? 437 00:23:12,359 --> 00:23:15,160 Speaker 1: We know for a fact. Okay, because wouldn't that be ironic? 438 00:23:15,720 --> 00:23:17,240 Speaker 1: All right, Well, thanks to all of you wrote in 439 00:23:17,280 --> 00:23:18,919 Speaker 1: to correct me. You know how much I love that. 440 00:23:19,440 --> 00:23:21,560 Speaker 1: And if you want to send a correction in or 441 00:23:21,600 --> 00:23:24,760 Speaker 1: tell Chuck that his hair is beyond awesome, you can 442 00:23:24,800 --> 00:23:28,800 Speaker 1: do that by sending an email to Stuff Podcast at 443 00:23:28,840 --> 00:23:34,960 Speaker 1: how stuff works dot com for more on this and 444 00:23:35,080 --> 00:23:37,640 Speaker 1: thousands of other topics. Is it how stuff works dot 445 00:23:37,640 --> 00:23:43,560 Speaker 1: com brought to you by the reinvented two thousand twelve Camray. 446 00:23:43,760 --> 00:23:44,960 Speaker 1: It's ready, are you