WEBVTT - Ep 54 Wake Up and Smell the Caffeine

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<v Speaker 1>Hi, I'm Aaron Welsh, and I'm Aaron Oman Updike.

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<v Speaker 2>And I'm Matt can Daz.

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<v Speaker 1>And this is this podcast will Kill You Crossover Edition.

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<v Speaker 2>Within Defensive Plans.

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<v Speaker 1>Yes, I'm so excit.

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<v Speaker 3>I did really excited. We've been waiting a long time.

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<v Speaker 3>I can't believe this is the first one we've done

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<v Speaker 3>this season.

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<v Speaker 1>That's not we did Risin.

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<v Speaker 3>When was that?

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<v Speaker 2>That felt like forever ago? By the way, it was.

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<v Speaker 3>Like seven years ago.

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<v Speaker 2>Easily much has changed in the meantime.

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<v Speaker 3>I don't remember anything about Ricin.

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<v Speaker 1>I gotta tell you come on the umbrellas like Pellett.

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<v Speaker 3>Oh yeah, okay, what bad seed?

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<v Speaker 2>I thought about it yesterday when I was covered in ticks.

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<v Speaker 3>Oh yeah, okay, now I remember. Thanks for reminding me.

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<v Speaker 1>There's so much. I feel like if somebody drew up

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<v Speaker 1>a pop quiz of like facts I learned on TPWKY,

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<v Speaker 1>I would fail.

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<v Speaker 3>I'd be embarrassing.

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<v Speaker 2>I had someone write me the other day and say,

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<v Speaker 2>in one episode you said this, but then in another

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<v Speaker 2>episode you contradicted your your perception on that. I was like,

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<v Speaker 2>I don't know, I changed my mind. I guess I

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<v Speaker 2>don't even remember saying that. Cool thank you for paying attention.

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<v Speaker 1>Oh well, what are we talking about on this very

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<v Speaker 1>exciting crossover episode.

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<v Speaker 3>We're talking about the thing keeping me alive right now,

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<v Speaker 3>and that is caffeine.

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<v Speaker 2>My heart just swells when you say it.

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<v Speaker 1>I mean how much when I was when you guys

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<v Speaker 1>were reading about this or researching this, how much were

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<v Speaker 1>you craving coffee or tea or chocolate or whatever it was.

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<v Speaker 3>I have had no less than six cups of coffee

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<v Speaker 3>in the last thirty six hours, in which I have

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<v Speaker 3>also had less than two hours of discontinuous sleep.

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<v Speaker 1>That doesn't sound great, Eric.

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<v Speaker 2>Ooh yeah, mental health. Take care of yourself.

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<v Speaker 3>We can talk about why it works, though it's gonna.

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<v Speaker 1>Be really exciting. Why it works for now?

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<v Speaker 3>Yep.

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<v Speaker 2>Well, I did all my research in the morning while

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<v Speaker 2>I was drinking coffee, so it was perfect.

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<v Speaker 1>Oh excellent. So to celebrate this wonderful thing to which

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<v Speaker 1>we are all I can assume addicted. What are we drinking?

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<v Speaker 1>What's our quarantini?

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<v Speaker 3>It's the caffeined get it?

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<v Speaker 1>Yeah?

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<v Speaker 3>Oh, Aaron, what's in the caffeine?

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<v Speaker 1>It's kind of like a take on a white Russian

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<v Speaker 1>So it's vodka. It's got Kalua. It's got chai tea

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<v Speaker 1>syrup cream, and then to make it even more caffeine friendly,

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<v Speaker 1>we're gonna toss in like a swirl of chocolate syrup

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<v Speaker 1>on top and then garnish with like a cinnamon stick

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<v Speaker 1>if you have one. Yeah, I'm not sure that I.

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<v Speaker 2>Do so I'm allergic to cinnamon.

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<v Speaker 1>So no, no, entirely.

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<v Speaker 2>Yeah, it's tragedy, pure tragedy.

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<v Speaker 3>We'll post the full recipe for that quarantini as well

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<v Speaker 3>as our non alcoholic but still caffeine friendly plus see

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<v Speaker 3>ber Rita on our social media channels and our website.

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<v Speaker 3>This podcast will kill you dot com.

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<v Speaker 1>We sure will. So we just did an awesome interview today.

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<v Speaker 1>It was so much fun with Corey from opp which

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<v Speaker 1>is Other People's Podcast. It's a podcast where he interviews

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<v Speaker 1>other people about their podcasts.

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<v Speaker 3>It's super fun.

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<v Speaker 1>It's really fun. It was such a great experience. You

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<v Speaker 1>guys should go check it out.

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<v Speaker 3>Yeah, thanks for having a song, Corey. It was so fun.

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<v Speaker 1>All right, So now ZEP, business done taken care.

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<v Speaker 3>Of I think we took care of taking care of business, TCOB.

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<v Speaker 3>This is going to be a great episode.

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<v Speaker 1>Well, I think we already need a short break, maybe,

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<v Speaker 1>I definitely think, so, all right, we'll do that and

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<v Speaker 1>then we'll come back with some caffeine, okay, the story

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<v Speaker 1>of caffeine. So when I was preparing this, I was like, Okay,

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<v Speaker 1>I don't know if I should concentrate more on coffee

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<v Speaker 1>or tea, or cacao or any of the other caffeine

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<v Speaker 1>containing plants or foods or beverages that we consume. And

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<v Speaker 1>I'm sure, Matt, you'll talk about some of those other ones. Yeah,

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<v Speaker 1>And then one thought that occurred to me was like,

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<v Speaker 1>maybe I'll write out a different history for each of those.

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<v Speaker 1>I'll do I'll write out a thing for coffee, I'll

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<v Speaker 1>write out a thing for tea, and I'll write out

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<v Speaker 1>a thing for cacao. And I'll be like, you guys

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<v Speaker 1>choose they could choose your own adventure. And then I

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<v Speaker 1>was like, why would I do that to myself?

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<v Speaker 2>Each one of those is a novel in and of itself.

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<v Speaker 1>Yeah. I struggled. So instead I decided to just do

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<v Speaker 1>a very general overview of caffeine, mostly concentrating on the

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<v Speaker 1>big hitters coffee and tea, with a little bit of

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<v Speaker 1>cacao thrown in there. Awesome So I want to start

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<v Speaker 1>by just going over a little bit of the origin stories,

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<v Speaker 1>the best part of every superhero movie. So let's start

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<v Speaker 1>with tea. So tea was supposedly discovered by shen Nung,

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<v Speaker 1>the mythical first Emperor of China and the inventor of

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<v Speaker 1>all kinds of things, from animal husbandry to the plow,

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<v Speaker 1>to plant based medicine, and of course tea. And so

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<v Speaker 1>the story goes a little something like this. One day

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<v Speaker 1>shen Nung sat down under a shady shrub to escape

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<v Speaker 1>the heat in a particularly hot day, and then he

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<v Speaker 1>decided to cool off by building a fire. I don't

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<v Speaker 1>understand how that would work, and then boiling some water

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<v Speaker 1>to drink again doesn't seem like a particularly cool down experience.

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<v Speaker 1>You know, the boiled water thing actually did make sense

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<v Speaker 1>because he had noticed that people who boiled their water

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<v Speaker 1>tended to get sick less often, which is pretty cool.

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<v Speaker 1>But as he was building up his fire by adding

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<v Speaker 1>more branches, a few of the leaves on the shrub

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<v Speaker 1>that he was sitting under, they just like happened to

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<v Speaker 1>fall into his pot of boiling water, and he was like,

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<v Speaker 1>you know what, I'm not dipping my hand in there

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<v Speaker 1>and scooping them out. I'm just gonna let them stay

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<v Speaker 1>in the water. And then he drank it and he

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<v Speaker 1>was like, what is this? This is delicious. I want

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<v Speaker 1>to drink more of this. I need to tell everyone

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<v Speaker 1>about this. And of course it was tea.

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<v Speaker 3>Can I just say that story reminds me a lot

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<v Speaker 3>of the Willow story of the guy trying to take

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<v Speaker 3>a rest behind a tree and then chewing on some

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<v Speaker 3>bark and being like, ooh my pain is gone.

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<v Speaker 1>Yeah, yeah, oh fun. Always these fortuitous discoveries that just

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<v Speaker 1>somehow under trees, get under.

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<v Speaker 2>Trees if you're stumped, just you know where to sit.

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<v Speaker 3>On a stump.

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<v Speaker 1>Oh that was so dorky. I liked it. I'm for it, okay. So,

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<v Speaker 1>also in addition to being the discoverer of tea, he

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<v Speaker 1>also recognized a lot of the stimulatory is that a

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<v Speaker 1>word properties of tea. So he actually kept track of

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<v Speaker 1>his own medical records. So there are like hundreds of

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<v Speaker 1>pages of his own like this is what my bladder was, like,

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<v Speaker 1>this is what my temperature was whatever, and this is

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<v Speaker 1>what the bile was. But he wrote down in his

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<v Speaker 1>records that tea was good for tumors or abscesses that

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<v Speaker 1>come about the head or for ailments of the bladder.

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<v Speaker 1>It dissipates heat caused by phlems or inflammation of the chest.

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<v Speaker 1>It quenches thirst, it lessens the desire for sleep. It

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<v Speaker 1>gladdens and cheers the heart. Also true, and so because

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<v Speaker 1>of these amazing benefits of tea, this drink steadily grew

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<v Speaker 1>in popularity in China and then downright exploded during the

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<v Speaker 1>Tang dynasty between six hundred and nine hundred CE. But

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<v Speaker 1>outside of China, the first references to tea come from

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<v Speaker 1>about nine hundred CE in writings by Arab traders. But

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<v Speaker 1>no one in Europe or the New World or anywhere

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<v Speaker 1>else really knew that much about tea or cared to

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<v Speaker 1>investigate it further until the mid fifteen hundreds, despite the

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<v Speaker 1>fact that there was, you know, ample trade going on.

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<v Speaker 1>But remember that date in mid fifteen hundreds. Okay, okay,

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<v Speaker 1>So now coffee, the coffee bush, as I'm sure you'll

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<v Speaker 1>talk about, maybe matt grows throughout Africa, and that's probably

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<v Speaker 1>where it originated, like Ethiopia area.

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<v Speaker 2>Yeah, I've heard like sort of Middle Eastern.

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<v Speaker 1>Middle Eastern, like Yemen, Ethiopia areas, But it doesn't seem

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<v Speaker 1>that coffee was used by or even known to anyone

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<v Speaker 1>in any of like the a worlds like ancient Greece,

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<v Speaker 1>Ancient Rome, ancient Middle East, or ancient Africa. There is

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<v Speaker 1>some evidence that in Ethiopia, coffee beans were first consumed

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<v Speaker 1>by people, possibly as small balls consisting of like the

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<v Speaker 1>ground fruit and then the bean itself, and then packed

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<v Speaker 1>together with lard to make like a little energy ball,

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<v Speaker 1>energy bites, energy bytes. I mean, I mean, I have

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<v Speaker 1>always loved eating like chocolate covered coffee beans, and then

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<v Speaker 1>I find myself being like, why do why can't I sleep?

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<v Speaker 1>Why do I feel?

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<v Speaker 3>So?

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<v Speaker 1>What's the word alert on edge? On edge?

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<v Speaker 2>Yeah, my grandmother used to give them to me as

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<v Speaker 2>a kid, and she would call them goatterds. She's like,

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<v Speaker 2>you want some goat ds? And eventually I learned that, yeah,

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<v Speaker 2>I do.

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<v Speaker 1>Like, that's not going to put me off them.

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<v Speaker 2>Yeah, welcome to my life.

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<v Speaker 1>Well, and then there's the whole thing about like the

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<v Speaker 1>civet and the most expensive coffee in the world is

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<v Speaker 1>like the one that has been passed through a civet's

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<v Speaker 1>intestines poop bowels. Yeah, anyway, okay, And so there are

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<v Speaker 1>some historical references to ancient documents or accounts of coffee

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<v Speaker 1>drinking as early as the sixth century, but the earliest

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<v Speaker 1>indisputable records put that timing as no earlier than the

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<v Speaker 1>middle of the fifteenth century. In the Sufi monasteries of

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<v Speaker 1>the Yemen in southern Arabia, and this story goes a

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<v Speaker 1>little something like this, and Ethiopian goatherd named Kaldi was

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<v Speaker 1>out hurting his goats one day when he noticed his

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<v Speaker 1>flock nibbling on some bright red berries on a certain bush,

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<v Speaker 1>and they wouldn't come over when he called. But when

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<v Speaker 1>he found them, they were all jumping and kind of

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<v Speaker 1>like frantically and frenzied dancing around. He was like, okay,

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<v Speaker 1>it has to do something with these red berries on

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<v Speaker 1>this bush. So what would happen if I tasted them?

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<v Speaker 1>So he chewed on some of the berries himself, and

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<v Speaker 1>he liked what he tasted. So he's like, all right,

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<v Speaker 1>I'm going to gather a handful of these and bring

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<v Speaker 1>them to the nearby monastery. But the holy men of

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<v Speaker 1>the monastery did not approve of these devilish red berries,

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<v Speaker 1>and so they threw them into the fire, which then

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<v Speaker 1>only led to the most delicious smelling aroma, and they

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<v Speaker 1>were like, well, not so fast. So they dragged these

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<v Speaker 1>beans from the ashes, ground them up, and then dissolved

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<v Speaker 1>them in hot water, leading to the first cup of coffee.

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<v Speaker 3>What an interesting story.

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<v Speaker 2>I mean, so many steps in there. I would have

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<v Speaker 2>loved to see sort of the thought process.

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<v Speaker 1>Back to the fire you must go so these I mean,

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<v Speaker 1>of course, this story, just as the one previous, might

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<v Speaker 1>just be a story like right, But somehow, somehow, the

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<v Speaker 1>infusion of both tea leaves and coffee beans had led

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<v Speaker 1>to this discovery that whatever the infusion was was delicious

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<v Speaker 1>in some way, even though it's bitter and surprising, people

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<v Speaker 1>found it that delicious. But maybe that's just the power

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<v Speaker 1>of caffeine. Okay, So now cacao. Cacao was first cultivated

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<v Speaker 1>not by Mayans but by the Olemes who lived in

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<v Speaker 1>the lowlands of Mexico from around fifteen hundred to five

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<v Speaker 1>hundred BCE, and they used the cacao pods to make

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<v Speaker 1>a chocolate drink. And there's even evidence on a pottery

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<v Speaker 1>jar from like five hundred CE found in Guatemala that

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<v Speaker 1>has hieroglyphs that indicate cacao and analysis like an analysis

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<v Speaker 1>of the contents of the pot showed traces of caffeine

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<v Speaker 1>and through theobromine nice, and the drink was called chocolatl

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<v Speaker 1>of course. And then the Mayans after them, So the

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<v Speaker 1>Mayans after the Olmes so around one thousand BCE to

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<v Speaker 1>two fifty CE, followed the Omex in this using cacao

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<v Speaker 1>as currency often, and then after the Mayans it was

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<v Speaker 1>picked up by the toll Text between the tenth and

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<v Speaker 1>twelfth centuries, and then finally by the Aztecs from the

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<v Speaker 1>twelfth centuries until the Spanish CONQUESTA arrived in the mid

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<v Speaker 1>fifteen hundreds and had chocolate for the first time and

0:14:06.080 --> 0:14:13.640
<v Speaker 1>then destroyed everything. Yeah, and so like also just a

0:14:13.640 --> 0:14:17.040
<v Speaker 1>note on naming. When Cortes first arrived to you know,

0:14:17.120 --> 0:14:20.480
<v Speaker 1>start the fall of the Aztec Empire, he was given chocolate,

0:14:20.560 --> 0:14:23.080
<v Speaker 1>you know, initially in this warm welcome and he was like,

0:14:23.120 --> 0:14:25.440
<v Speaker 1>this is so delicious, this is the drink of the gods.

0:14:25.600 --> 0:14:27.440
<v Speaker 1>Hence theobroma cacao.

0:14:28.880 --> 0:14:31.240
<v Speaker 2>Wow. Yeah, I don't think I ever put.

0:14:31.040 --> 0:14:39.120
<v Speaker 1>That together, Okay, So with tea, coffee and chocolate. I

0:14:39.160 --> 0:14:41.840
<v Speaker 1>stopped at around the mid fifteen hundreds because that was

0:14:42.280 --> 0:14:45.120
<v Speaker 1>in general, the time when each of those stopped being

0:14:45.240 --> 0:14:49.480
<v Speaker 1>known to only the region they originated in, and that's

0:14:49.520 --> 0:14:53.800
<v Speaker 1>when they began this worldwide tour of notoriety that would

0:14:53.880 --> 0:14:58.560
<v Speaker 1>lead to caffeine consumption on a scale that has never decreased.

0:14:59.360 --> 0:15:03.640
<v Speaker 3>That is so interesting that all three kind of coalesced

0:15:04.360 --> 0:15:05.440
<v Speaker 3>at the same time.

0:15:06.120 --> 0:15:07.720
<v Speaker 1>I think a lot of it has to do also

0:15:07.760 --> 0:15:12.800
<v Speaker 1>with just the timing of like when long distance traveling

0:15:13.560 --> 0:15:17.120
<v Speaker 1>was made more possible and when you know, sort of

0:15:17.200 --> 0:15:19.120
<v Speaker 1>as it coincided with as we talked about in the

0:15:19.160 --> 0:15:22.520
<v Speaker 1>Screwby episode. I think like there was all of a

0:15:22.560 --> 0:15:25.479
<v Speaker 1>sudden a need to go trade more, and the shipbuilding

0:15:25.520 --> 0:15:29.120
<v Speaker 1>really increased, and that technology for traveling long distances increased.

0:15:29.160 --> 0:15:32.200
<v Speaker 1>And then of course, like when you find something like

0:15:32.920 --> 0:15:36.360
<v Speaker 1>this that is widely consumed in a certain area and

0:15:36.440 --> 0:15:40.080
<v Speaker 1>found to be delicious, you are probably one of the

0:15:40.120 --> 0:15:42.040
<v Speaker 1>things that first occurs to you is how can I

0:15:42.080 --> 0:15:44.040
<v Speaker 1>make money off this? How can I progress this?

0:15:44.520 --> 0:15:45.080
<v Speaker 3>Of course?

0:15:45.200 --> 0:15:48.160
<v Speaker 2>Yeah, And like I mean, we all use it for productivity.

0:15:48.200 --> 0:15:51.240
<v Speaker 2>Imagine when that started to catch on among all of

0:15:51.280 --> 0:15:56.040
<v Speaker 2>the already crazy economic progress quote unquote that was happening.

0:15:56.280 --> 0:15:59.920
<v Speaker 1>Oh yeah, yeah, exactly, and so these yeah, of course,

0:16:00.080 --> 0:16:03.240
<v Speaker 1>began to be highly sought after, particularly in Europe and

0:16:03.280 --> 0:16:07.720
<v Speaker 1>North America during the sixteen hundreds when colonialism was raging,

0:16:07.800 --> 0:16:12.720
<v Speaker 1>of course, and these caffeinated beverages may have come along

0:16:12.800 --> 0:16:16.600
<v Speaker 1>at just the right time. So temperance movements in Europe

0:16:16.840 --> 0:16:20.360
<v Speaker 1>had happened before. They had started and failed, and started

0:16:20.360 --> 0:16:24.240
<v Speaker 1>and failed long before coffee and tea came onto the scene.

0:16:24.480 --> 0:16:28.200
<v Speaker 1>And they failed largely because the proponents of these movements

0:16:28.240 --> 0:16:32.720
<v Speaker 1>didn't have an alternative beverage to suggest to replace alcohol.

0:16:33.040 --> 0:16:35.560
<v Speaker 1>They were like, you need to stop drinking. And they

0:16:35.600 --> 0:16:37.520
<v Speaker 1>were like, all right, maybe I will, but what should

0:16:37.520 --> 0:16:42.960
<v Speaker 1>I drink instead? Drink the poop infused water, Like, no,

0:16:44.240 --> 0:16:48.720
<v Speaker 1>it's not good. And so when coffee and tea and

0:16:48.800 --> 0:16:52.240
<v Speaker 1>hot chocolate came onto the scene, alcohol at that time

0:16:52.440 --> 0:16:57.280
<v Speaker 1>was consumed at every meal, breakfast, lunch, dinner by every

0:16:57.320 --> 0:17:00.440
<v Speaker 1>person in Europe, whether you're a child or some who's

0:17:00.480 --> 0:17:04.960
<v Speaker 1>working or someone who's elderly. You know, it was ubiquitous.

0:17:05.640 --> 0:17:08.000
<v Speaker 1>And you know, in a way alcohol was safer than

0:17:08.040 --> 0:17:11.360
<v Speaker 1>the water because at least killed a lot of the germs.

0:17:12.760 --> 0:17:15.760
<v Speaker 1>So when tea and coffee replaced the morning beer or

0:17:15.760 --> 0:17:19.159
<v Speaker 1>the lunchtime poor people saw a noticeable shift in the

0:17:19.200 --> 0:17:25.000
<v Speaker 1>productivity and safety of the workplace. I mean, to go fague, like,

0:17:25.080 --> 0:17:28.640
<v Speaker 1>I never even thought of it. And there's the fact

0:17:28.680 --> 0:17:32.200
<v Speaker 1>that these beverages were boiled, and so that also reduced

0:17:32.200 --> 0:17:35.320
<v Speaker 1>the chance of getting some sort of water born pathogen

0:17:35.400 --> 0:17:36.040
<v Speaker 1>or parasite.

0:17:36.600 --> 0:17:41.359
<v Speaker 2>What a massive cultural shift to go from being drunk

0:17:41.400 --> 0:17:45.760
<v Speaker 2>all day to just drinking caffeine all day. That must

0:17:45.840 --> 0:17:46.879
<v Speaker 2>have been huge.

0:17:46.920 --> 0:17:51.359
<v Speaker 1>It's huge, It's it's wild. And so these caffeine drinks,

0:17:51.400 --> 0:17:54.600
<v Speaker 1>these caffeinated drinks were credited or have been credited, with

0:17:54.760 --> 0:17:59.280
<v Speaker 1>shaping the entire European workforce and leading to a burst

0:17:59.320 --> 0:18:03.800
<v Speaker 1>of creativity, an ingenuity. Eventually that paved the way for

0:18:03.840 --> 0:18:06.000
<v Speaker 1>the industrial revolution. I mean, it's a bit of a

0:18:06.240 --> 0:18:08.280
<v Speaker 1>you know, maybe that's a stretch, but I don't know,

0:18:08.800 --> 0:18:09.720
<v Speaker 1>it's not a stretch.

0:18:09.880 --> 0:18:10.560
<v Speaker 3>Let's take it.

0:18:10.880 --> 0:18:12.240
<v Speaker 2>Let's just say it made an impact.

0:18:12.480 --> 0:18:17.640
<v Speaker 1>And then so that is so cool. Isn't that amazing?

0:18:18.560 --> 0:18:22.280
<v Speaker 1>And these beverages were also held to be indirectly responsible

0:18:22.359 --> 0:18:28.880
<v Speaker 1>for other kinds of revolutions, namely political ones. So tea houses,

0:18:29.000 --> 0:18:32.720
<v Speaker 1>which had been popular in China since the thirteenth century CE,

0:18:33.200 --> 0:18:36.960
<v Speaker 1>they started to become popular in Europe and in the

0:18:37.000 --> 0:18:40.280
<v Speaker 1>New World as well, and coffee houses also sprung up

0:18:40.720 --> 0:18:44.960
<v Speaker 1>and were incredibly widespread and popular, Like the amount of

0:18:44.960 --> 0:18:49.600
<v Speaker 1>coffee houses per per capita was like maybe only we

0:18:49.760 --> 0:18:53.879
<v Speaker 1>now have reached it and so. And for instance, in

0:18:53.960 --> 0:18:57.240
<v Speaker 1>England they were given the name Penny universities to describe

0:18:57.280 --> 0:19:00.240
<v Speaker 1>how people and men were only allowed in the coffee

0:19:00.240 --> 0:19:02.720
<v Speaker 1>houses at the time, how men would go to these

0:19:02.760 --> 0:19:06.159
<v Speaker 1>coffee houses to talk about philosophy or politics, or to

0:19:06.160 --> 0:19:09.600
<v Speaker 1>hear music or poetry. So like, in many ways they

0:19:09.600 --> 0:19:11.960
<v Speaker 1>still exist in the same capacity today, which I think

0:19:12.000 --> 0:19:14.280
<v Speaker 1>is really interesting, like the open mic night at the

0:19:14.280 --> 0:19:14.920
<v Speaker 1>coffee house.

0:19:15.280 --> 0:19:18.680
<v Speaker 3>Yeah, it's like a gathering place, not just yeah.

0:19:18.320 --> 0:19:21.680
<v Speaker 1>Not just and so like some of the documentaries that

0:19:21.760 --> 0:19:25.359
<v Speaker 1>I watched was like, you know, would the same political

0:19:25.400 --> 0:19:29.040
<v Speaker 1>discourse be held at a bar and the same actions

0:19:29.080 --> 0:19:31.440
<v Speaker 1>be planned in like a logical way then they would

0:19:31.480 --> 0:19:34.000
<v Speaker 1>be at a coffee house fueled by alcohol versus fueled

0:19:34.040 --> 0:19:37.520
<v Speaker 1>by caffeine. Like when are you going to most get

0:19:37.560 --> 0:19:40.280
<v Speaker 1>the ends that you're planning? I guess, I don't know.

0:19:41.080 --> 0:19:44.760
<v Speaker 1>Fascinating interesting to think about. There were still temperance movements,

0:19:45.000 --> 0:19:48.480
<v Speaker 1>but this time against coffee primarily and also tea, or

0:19:48.480 --> 0:19:51.840
<v Speaker 1>it was like alternatively coffee and then tea. But yeah,

0:19:51.840 --> 0:19:54.320
<v Speaker 1>so back on the revolution thing. In the British colonies

0:19:54.320 --> 0:19:58.000
<v Speaker 1>of the New World, coffee houses in Boston were essentially

0:19:58.040 --> 0:20:02.080
<v Speaker 1>the headquarters of the American Revolution. The Boston Tea Party

0:20:02.440 --> 0:20:05.080
<v Speaker 1>was planned at a coffee house called the Green Dragon,

0:20:05.480 --> 0:20:08.400
<v Speaker 1>and the first public reading of the Declaration of Independence

0:20:08.480 --> 0:20:11.720
<v Speaker 1>was held at another Boston coffee house, the Bunch of Grapes.

0:20:12.520 --> 0:20:14.240
<v Speaker 3>Nice, that's funny, kind of a fun name.

0:20:15.280 --> 0:20:18.000
<v Speaker 1>And of course tea itself, or rather the import tax

0:20:18.040 --> 0:20:20.720
<v Speaker 1>on tea and the British government allowing the East India

0:20:20.720 --> 0:20:24.040
<v Speaker 1>Company to also tax the import of tea on the colonists.

0:20:24.200 --> 0:20:27.200
<v Speaker 1>That was all part of the reason for the American

0:20:27.240 --> 0:20:30.639
<v Speaker 1>Revolution in the first place. And that also kind of

0:20:30.680 --> 0:20:33.760
<v Speaker 1>brings me to the dark side of coffee and tea

0:20:33.840 --> 0:20:35.760
<v Speaker 1>and chocolate. Yeah.

0:20:36.080 --> 0:20:38.080
<v Speaker 3>Always, it's always a dark side.

0:20:38.400 --> 0:20:42.960
<v Speaker 1>It's always a dark side. So coffee and tea were

0:20:42.960 --> 0:20:46.399
<v Speaker 1>both in incredibly high demand in European countries and in

0:20:46.440 --> 0:20:50.040
<v Speaker 1>the British colonies in the New World, but caffeine addiction

0:20:50.400 --> 0:20:53.320
<v Speaker 1>was an expensive habit to pick up in those early days.

0:20:53.600 --> 0:20:57.440
<v Speaker 1>As the cultivation of the plants was pretty restricted. So anytime,

0:20:57.520 --> 0:21:02.000
<v Speaker 1>for instance, that coffee beans were sent out from Mocha,

0:21:02.119 --> 0:21:04.800
<v Speaker 1>which is where they were primarily grown, they were made

0:21:04.800 --> 0:21:07.360
<v Speaker 1>sure to not able to be germinated or to not

0:21:07.400 --> 0:21:10.320
<v Speaker 1>be able to grow into any viable plants. And it's

0:21:10.320 --> 0:21:12.120
<v Speaker 1>sort of like what we saw with the Sanshona bark

0:21:12.240 --> 0:21:16.200
<v Speaker 1>in the malaria episode and restrictions on that plant being

0:21:16.600 --> 0:21:20.000
<v Speaker 1>grown elsewhere. But eventually, you know, where there's a will,

0:21:20.040 --> 0:21:22.520
<v Speaker 1>there's a way, and so people did manage to smuggle

0:21:22.560 --> 0:21:26.399
<v Speaker 1>out some coffee beans and a few tea seeds, and

0:21:26.440 --> 0:21:29.600
<v Speaker 1>so coffee was smuggled from Mocha and planted in the

0:21:29.680 --> 0:21:33.320
<v Speaker 1>Dutch controlled Java around sixteen sixteen. And that was also

0:21:33.440 --> 0:21:35.639
<v Speaker 1>found to be able to grow in many parts of

0:21:35.680 --> 0:21:39.560
<v Speaker 1>the New World which had the right humidity and temperature

0:21:39.600 --> 0:21:44.400
<v Speaker 1>and so on for the growth. And of course, if

0:21:44.440 --> 0:21:47.760
<v Speaker 1>you want to gather a lot of the coffee beans,

0:21:47.800 --> 0:21:49.520
<v Speaker 1>you have to gather them by hand. And what did

0:21:49.520 --> 0:21:51.600
<v Speaker 1>that take was a lot of hands. And so what

0:21:51.640 --> 0:21:55.040
<v Speaker 1>did that lead to but a lot of enslaved people

0:21:55.200 --> 0:21:58.640
<v Speaker 1>being forced to labor under horrific working conditions on all

0:21:58.680 --> 0:22:03.160
<v Speaker 1>these plantations in the New World. And of course, as

0:22:03.240 --> 0:22:06.440
<v Speaker 1>consumption and demand for coffee rows, so did the number

0:22:06.440 --> 0:22:11.240
<v Speaker 1>of enslaved people, and the popular habit of adding sugar

0:22:11.280 --> 0:22:15.240
<v Speaker 1>to coffee and tea ensured that the sugar plantations also

0:22:15.400 --> 0:22:17.360
<v Speaker 1>had a reason to exist.

0:22:17.080 --> 0:22:20.000
<v Speaker 2>Right jeez, Louise capital is.

0:22:20.160 --> 0:22:23.040
<v Speaker 1>And while all this was happening, England was racking up

0:22:23.080 --> 0:22:25.919
<v Speaker 1>a hefty debt to China in the tea trade, and

0:22:25.960 --> 0:22:29.280
<v Speaker 1>so they saw an alternative way to save some money

0:22:29.359 --> 0:22:31.879
<v Speaker 1>and to try to limit how much they were giving

0:22:31.880 --> 0:22:34.120
<v Speaker 1>in terms of like bringing the tea over from there.

0:22:34.200 --> 0:22:36.880
<v Speaker 1>So they were like, well, why don't we get some

0:22:37.400 --> 0:22:42.040
<v Speaker 1>tea seeds and start growing tea plants in our colony

0:22:42.359 --> 0:22:45.160
<v Speaker 1>in India, which was all of India and so Britain

0:22:45.240 --> 0:22:47.840
<v Speaker 1>ruled every India at the time. And so they planted

0:22:48.080 --> 0:22:51.560
<v Speaker 1>tons and tons and tons of tea plants, and they

0:22:52.080 --> 0:22:55.359
<v Speaker 1>hired you know, kind of putting hired in quotes because

0:22:55.520 --> 0:22:59.840
<v Speaker 1>like literally paid them almost nothing in backbreaking conditions. And

0:23:00.119 --> 0:23:04.160
<v Speaker 1>then at the same time they also grew a bunch

0:23:04.160 --> 0:23:07.800
<v Speaker 1>of opium and then smuggled that into China to then

0:23:08.840 --> 0:23:11.480
<v Speaker 1>addict the whole country and drive them into ruin.

0:23:11.600 --> 0:23:14.240
<v Speaker 2>So I had no idea.

0:23:14.160 --> 0:23:17.600
<v Speaker 1>There's a whole separate story of like the Opium Wars

0:23:17.680 --> 0:23:21.560
<v Speaker 1>and like the East India Company is like it's just

0:23:21.600 --> 0:23:26.320
<v Speaker 1>a massive story there. It's really fascinating. But read more

0:23:26.320 --> 0:23:31.719
<v Speaker 1>about it. Well, I don't have the information. But anyway,

0:23:31.800 --> 0:23:34.280
<v Speaker 1>So then tea because of this, because of all of

0:23:34.280 --> 0:23:36.879
<v Speaker 1>the tea that had been able to grow in India,

0:23:38.119 --> 0:23:40.480
<v Speaker 1>that flooded the market back in Britain and it toppled

0:23:40.480 --> 0:23:42.800
<v Speaker 1>coffee as the preferred beverage.

0:23:43.680 --> 0:23:44.040
<v Speaker 2>Wow.

0:23:44.520 --> 0:23:47.040
<v Speaker 1>So then and then that also led to like afternoon

0:23:47.119 --> 0:23:50.280
<v Speaker 1>tea and then eventually tea bags and you know all

0:23:50.320 --> 0:23:54.560
<v Speaker 1>these different cultures around tea and yeah, so anyway, okay,

0:23:54.600 --> 0:23:57.879
<v Speaker 1>So the eighteen hundred saw the continued popularity of these beverages.

0:23:57.920 --> 0:24:02.080
<v Speaker 1>And also eighteen nineteen saw the discovery of the caffeine

0:24:02.119 --> 0:24:05.520
<v Speaker 1>molecule by a young physician named rung Oh.

0:24:06.080 --> 0:24:08.720
<v Speaker 3>Wow, eighteen nineteen, okay.

0:24:08.920 --> 0:24:12.200
<v Speaker 1>And then the next year four other researchers were able

0:24:12.200 --> 0:24:15.640
<v Speaker 1>to isolate the compound. So kind of happened all at once.

0:24:16.640 --> 0:24:20.200
<v Speaker 1>But this discovery did not start the debate on the

0:24:20.240 --> 0:24:23.199
<v Speaker 1>healthy or harmful effects of caffeine, but rather continue it,

0:24:23.359 --> 0:24:27.040
<v Speaker 1>like this debate has been going on for ages and

0:24:27.160 --> 0:24:30.680
<v Speaker 1>still seems to be raging Aaron. I'm sure you'll talk

0:24:30.680 --> 0:24:34.040
<v Speaker 1>about that. Oh yes, And there's just a little bit

0:24:34.040 --> 0:24:36.280
<v Speaker 1>more of the history of caffeine that I want to

0:24:36.280 --> 0:24:39.480
<v Speaker 1>touch on. So caffeine played a huge role in the wars.

0:24:39.640 --> 0:24:43.359
<v Speaker 1>It was during the Civil War, during World War One,

0:24:43.440 --> 0:24:47.479
<v Speaker 1>during World War Two, given to soldiers like unlimited rations

0:24:47.560 --> 0:24:50.040
<v Speaker 1>of caffeine, whether in the form of caffeine powder, whether

0:24:50.080 --> 0:24:52.480
<v Speaker 1>in the form of unlimited tea, whether in the form

0:24:52.600 --> 0:24:58.440
<v Speaker 1>of coca cola, and it often was restricted to try

0:24:58.480 --> 0:25:02.040
<v Speaker 1>to like reduce the morale of whatever opposing side was there.

0:25:02.119 --> 0:25:05.720
<v Speaker 1>For instance, that happened during the American Civil War. And

0:25:05.760 --> 0:25:09.520
<v Speaker 1>then of course the twentieth century saw caffeine in many

0:25:09.560 --> 0:25:11.960
<v Speaker 1>different products, so we see the rise of it in

0:25:12.160 --> 0:25:16.600
<v Speaker 1>SODA's and then energy drinks, and then decaf and then

0:25:16.760 --> 0:25:21.280
<v Speaker 1>advertising wars, leading to basically the consumption and entire world

0:25:21.400 --> 0:25:25.600
<v Speaker 1>addicted to this compound, which is also of course what

0:25:25.720 --> 0:25:29.119
<v Speaker 1>then started a ton and ton and ton of research

0:25:29.800 --> 0:25:36.439
<v Speaker 1>over the safety of caffeine. But you know, this was

0:25:36.520 --> 0:25:40.439
<v Speaker 1>not a very well done history or whole history, but

0:25:40.600 --> 0:25:42.280
<v Speaker 1>hopefully what it has done is given you a little

0:25:42.280 --> 0:25:45.959
<v Speaker 1>bit of the taste of just the massive impact that

0:25:46.000 --> 0:25:50.840
<v Speaker 1>caffeine has had on the world's history and culture. And

0:25:51.040 --> 0:25:52.960
<v Speaker 1>just to like, I want to wrap up a little

0:25:53.000 --> 0:25:57.200
<v Speaker 1>bit by saying, like, there are some parallels between particularly

0:25:57.200 --> 0:26:00.560
<v Speaker 1>coffee and tea, so I just want to find some

0:26:00.640 --> 0:26:04.639
<v Speaker 1>patterns in these histories. So Number one, both of these

0:26:04.880 --> 0:26:08.040
<v Speaker 1>were harvested as a leaf or a berry and used

0:26:08.080 --> 0:26:11.720
<v Speaker 1>as a stimulant or medicine first, and they often held

0:26:11.840 --> 0:26:14.440
<v Speaker 1>great significance for the culture where they were first used.

0:26:15.160 --> 0:26:18.040
<v Speaker 1>Number two. Each was only used as an infused drink

0:26:18.119 --> 0:26:23.320
<v Speaker 1>relatively recently, so maybe starting in the fifteen hundreds. Number three,

0:26:23.359 --> 0:26:25.560
<v Speaker 1>each was brought into the region that they are now

0:26:25.600 --> 0:26:30.880
<v Speaker 1>associated with by religious devotees returning from another country. Number four,

0:26:30.960 --> 0:26:35.200
<v Speaker 1>their cultivation was protected. Number five they were used as currency,

0:26:35.280 --> 0:26:38.479
<v Speaker 1>So coffee beans were used as currency in Arabia, colon

0:26:38.520 --> 0:26:41.480
<v Speaker 1>nuts used this currency in Africa, cacal pods and mante

0:26:41.560 --> 0:26:44.679
<v Speaker 1>leaves in the Americas, and tea leaf bricks in China.

0:26:45.520 --> 0:26:48.640
<v Speaker 1>And I wanted the final point I wanted to make

0:26:48.760 --> 0:26:52.120
<v Speaker 1>is that number six and just as it has always

0:26:52.160 --> 0:26:55.480
<v Speaker 1>been in the present day, the people who were actually

0:26:55.520 --> 0:27:01.000
<v Speaker 1>farming and producing these products. See a minute school fraction

0:27:01.320 --> 0:27:03.880
<v Speaker 1>of the profit that eventually comes out of them. So

0:27:03.920 --> 0:27:06.440
<v Speaker 1>for every ten dollars that you spend on a bag

0:27:06.480 --> 0:27:09.760
<v Speaker 1>of coffee, for instance, the farmer who produced it sees

0:27:10.160 --> 0:27:14.159
<v Speaker 1>maybe a dollar of that. And that's just how it is.

0:27:14.200 --> 0:27:18.400
<v Speaker 1>There are some, you know, programs that seek to remedy

0:27:18.440 --> 0:27:21.760
<v Speaker 1>that or seek to make it a little bit more fair,

0:27:22.119 --> 0:27:28.880
<v Speaker 1>but it's debated whether they actually function. So anyway, that's

0:27:28.960 --> 0:27:33.840
<v Speaker 1>that's my story. Aaron, Please tell us why we are

0:27:33.880 --> 0:27:36.679
<v Speaker 1>so addicted to caffeine and why right now, just talking

0:27:36.720 --> 0:27:38.239
<v Speaker 1>about it makes me want to have a cup of

0:27:38.280 --> 0:27:41.320
<v Speaker 1>tea or an afternoon coffee.

0:27:41.440 --> 0:27:43.040
<v Speaker 2>I was just thinking, do we have decafs?

0:27:44.640 --> 0:27:46.879
<v Speaker 1>I know if I if I did have coffee right now,

0:27:46.880 --> 0:27:48.160
<v Speaker 1>I wouldn't be able to sleep for sure.

0:27:49.160 --> 0:27:49.880
<v Speaker 2>Yeah.

0:27:49.600 --> 0:27:51.280
<v Speaker 3>Yeah, do you guys want to know why?

0:27:51.920 --> 0:27:52.600
<v Speaker 1>Of course I do.

0:27:53.560 --> 0:28:30.719
<v Speaker 3>Let's take a quick break and then I'll talk about it. Excellent, okay, So, Aarin,

0:28:31.560 --> 0:28:37.720
<v Speaker 3>it's very interesting that you use the word addicted, because

0:28:37.760 --> 0:28:40.520
<v Speaker 3>I think a lot of us think of caffeine as

0:28:40.560 --> 0:28:43.520
<v Speaker 3>an addiction. I'm addicted to coffee. I'm addicted to coffee.

0:28:43.560 --> 0:28:48.360
<v Speaker 3>And it's true that caffeine is the most widely used

0:28:48.440 --> 0:28:54.320
<v Speaker 3>by far psychoactive substance drug in the world. I think

0:28:54.440 --> 0:28:59.440
<v Speaker 3>over eighty five percent of Americans, regardless of age, use caffeine.

0:28:59.720 --> 0:29:05.400
<v Speaker 1>Wow wow, right, regardless of age.

0:29:05.720 --> 0:29:08.760
<v Speaker 3>Yeah, so like so for adults it's like a lot

0:29:08.760 --> 0:29:11.560
<v Speaker 3>more than eighty five percent, and hopefully it's less kids.

0:29:11.600 --> 0:29:15.000
<v Speaker 3>But but there's like even but I mean because that

0:29:15.040 --> 0:29:19.240
<v Speaker 3>includes soda, right, and a lot kids drink soda and chocolate.

0:29:19.120 --> 0:29:23.640
<v Speaker 1>Which for a long time, soda companies, namely Coca Cola,

0:29:23.880 --> 0:29:26.600
<v Speaker 1>was like, oh, yeah, we caffeine is a is a

0:29:26.600 --> 0:29:29.520
<v Speaker 1>flavor additive, Like it's required to be there because it's

0:29:29.560 --> 0:29:32.560
<v Speaker 1>a flavor additive. It adds bitterness. But in like double

0:29:32.560 --> 0:29:35.680
<v Speaker 1>blind studies, people couldn't detect the difference, and so it

0:29:35.760 --> 0:29:37.520
<v Speaker 1>was like, are you just doing this to addict to

0:29:37.520 --> 0:29:40.080
<v Speaker 1>the children? To caffeine tep into a whole new market.

0:29:40.320 --> 0:29:42.640
<v Speaker 1>But then there's sugar, so like is that addictive? You

0:29:42.680 --> 0:29:43.280
<v Speaker 1>know whatever?

0:29:44.080 --> 0:29:49.120
<v Speaker 3>Yeah, So there's no like diagnosis of caffeine addiction. And

0:29:49.200 --> 0:29:52.480
<v Speaker 3>so whether or not you consider caffeine to be something

0:29:52.520 --> 0:29:56.000
<v Speaker 3>addictive kind of depends on what the definition of addictive is,

0:29:56.640 --> 0:29:58.960
<v Speaker 3>which is a whole nother debate that I am not

0:29:59.080 --> 0:30:02.240
<v Speaker 3>even going to get in. But it is true that

0:30:02.720 --> 0:30:06.959
<v Speaker 3>caffeine has effects on your nervous system such that with

0:30:07.080 --> 0:30:12.640
<v Speaker 3>habitual use, if you stop using caffeine, you will experience

0:30:12.720 --> 0:30:15.719
<v Speaker 3>things like withdrawal symptoms, and so that means you can

0:30:15.760 --> 0:30:19.800
<v Speaker 3>become dependent on caffeine, which is something that's often part

0:30:19.920 --> 0:30:24.840
<v Speaker 3>of a diagnosis of something like addiction. So let's talk

0:30:24.880 --> 0:30:28.080
<v Speaker 3>a little bit more about the effects of caffeine on

0:30:28.120 --> 0:30:33.120
<v Speaker 3>your brain. Okay, ye, all right, we all drink caffeine.

0:30:33.200 --> 0:30:34.720
<v Speaker 2>Is that correct? Three of us?

0:30:34.720 --> 0:30:39.920
<v Speaker 3>Oh yeah, okay, tell me what it feels like when

0:30:39.960 --> 0:30:42.960
<v Speaker 3>you drink a cup of coffee. What are your symptoms?

0:30:43.640 --> 0:30:45.280
<v Speaker 2>I have to run to the bathroom really quick.

0:30:49.120 --> 0:30:51.120
<v Speaker 3>Okay, thank you for that, honest.

0:30:51.240 --> 0:30:54.840
<v Speaker 2>Now, Euphoria, excitement, heartbeats.

0:30:54.560 --> 0:30:59.160
<v Speaker 1>Go up, okay, alertness. I always feel like I kind

0:30:59.160 --> 0:31:01.960
<v Speaker 1>of have like a beginning period of this feels great

0:31:01.960 --> 0:31:04.200
<v Speaker 1>and awesome, and I'm finally like where I need to

0:31:04.240 --> 0:31:06.680
<v Speaker 1>be in my morning, and then my bones start to

0:31:06.720 --> 0:31:10.479
<v Speaker 1>feel hollow, and I get like, does that not a thing?

0:31:10.520 --> 0:31:14.560
<v Speaker 1>Where I'm like, I feel so like jittery and jittery. Okay,

0:31:14.600 --> 0:31:15.520
<v Speaker 1>But I also.

0:31:17.080 --> 0:31:17.320
<v Speaker 2>Is it?

0:31:17.440 --> 0:31:19.720
<v Speaker 1>Okay? I have so many questions that I'm getting ahead

0:31:19.720 --> 0:31:21.480
<v Speaker 1>of myself. I'm like, but I don't eat breakfast, so

0:31:21.560 --> 0:31:25.280
<v Speaker 1>does that have an impact? You know? But mostly I

0:31:25.280 --> 0:31:27.520
<v Speaker 1>feel like I'm talking right now, which is like a

0:31:27.560 --> 0:31:29.760
<v Speaker 1>mile a minute. My brain's very focused.

0:31:30.080 --> 0:31:33.720
<v Speaker 3>Okay, great, you guys are hitting on a lot of

0:31:33.760 --> 0:31:38.200
<v Speaker 3>the effects of caffeine. Okay. So it's a stimulant, so

0:31:38.400 --> 0:31:41.200
<v Speaker 3>it has an effect on your central nervous system. So

0:31:41.360 --> 0:31:43.360
<v Speaker 3>the reason that it's able to have an effect on

0:31:43.400 --> 0:31:47.280
<v Speaker 3>your CNS is because when you ingest caffeine, generally we

0:31:47.440 --> 0:31:50.640
<v Speaker 3>ingest it orally right, So you drink a cup of coffee,

0:31:50.720 --> 0:31:52.800
<v Speaker 3>or you pop a caffeine pill, or you sip a

0:31:52.800 --> 0:31:56.280
<v Speaker 3>cup of tea, and almost one hundred percent of that

0:31:56.480 --> 0:32:00.440
<v Speaker 3>caffeine becomes bioavailable, so you absorb it through your testin

0:32:00.800 --> 0:32:06.560
<v Speaker 3>and it goes into your bloodstream. Caffeine is a lipophilic molecule,

0:32:06.640 --> 0:32:10.640
<v Speaker 3>so it can pass through lipid membranes, which means it

0:32:10.680 --> 0:32:13.440
<v Speaker 3>can pass through your blood brain barrier and get into

0:32:13.480 --> 0:32:17.479
<v Speaker 3>your central nervous system right away. And within like an

0:32:17.640 --> 0:32:21.320
<v Speaker 3>hour of consuming caffeine, your blood levels and your plasma

0:32:21.400 --> 0:32:24.640
<v Speaker 3>levels are almost equivalent, so it kind of like distributes

0:32:24.680 --> 0:32:29.840
<v Speaker 3>equally throughout your tissues, including your brain. Okay, so we

0:32:29.960 --> 0:32:32.760
<v Speaker 3>know that it's overall going to keep you awake, and

0:32:32.800 --> 0:32:34.840
<v Speaker 3>now we know that it can get into your brain,

0:32:35.040 --> 0:32:36.720
<v Speaker 3>so it's going to have some effect there. But the

0:32:36.800 --> 0:32:39.480
<v Speaker 3>question is really like what is it doing on a

0:32:39.520 --> 0:32:44.479
<v Speaker 3>molecular level? And this is really fun and I'm going

0:32:44.560 --> 0:32:47.840
<v Speaker 3>to keep it really pretty simple and basic because there's

0:32:47.880 --> 0:32:51.080
<v Speaker 3>a lot of nitty gritty biochem here that I just

0:32:52.480 --> 0:32:54.800
<v Speaker 3>I don't have enough caffeine in me to get into

0:32:55.160 --> 0:32:59.640
<v Speaker 3>that nitty gritty detail. So what we need to know

0:32:59.800 --> 0:33:03.000
<v Speaker 3>is that depending on the concentration of caffeine when we

0:33:03.080 --> 0:33:06.280
<v Speaker 3>look in like cell culture studies or animal model studies,

0:33:06.640 --> 0:33:09.080
<v Speaker 3>we know that it can have a lot of different

0:33:09.160 --> 0:33:13.920
<v Speaker 3>effects on cells, right, Like, it interacts with cells and

0:33:14.000 --> 0:33:17.000
<v Speaker 3>can cause a lot of different things when you look

0:33:17.040 --> 0:33:19.840
<v Speaker 3>at them in an animal. But when you ingest it

0:33:20.400 --> 0:33:23.440
<v Speaker 3>like you're drinking a cup of coffee, the amount that

0:33:23.480 --> 0:33:26.880
<v Speaker 3>you would ingest with that there's really only one main

0:33:28.000 --> 0:33:31.760
<v Speaker 3>receptor that caffeine is going to interact with, and that

0:33:31.920 --> 0:33:37.880
<v Speaker 3>is with the adenazine receptors. So adenazine might sound familiar.

0:33:38.400 --> 0:33:41.360
<v Speaker 3>Does it sound familiar to you, guys? Why does it

0:33:41.440 --> 0:33:47.880
<v Speaker 3>sound familiar? Atp ATP so adenozine triphosphate or ATP is

0:33:47.960 --> 0:33:52.280
<v Speaker 3>like the energy of all of our cells. Okay, So

0:33:53.360 --> 0:33:57.040
<v Speaker 3>when your cells use a bunch of energy, like your brain.

0:33:57.080 --> 0:33:59.480
<v Speaker 3>For example, if your brain is working really hard because

0:33:59.480 --> 0:34:02.560
<v Speaker 3>you're or your muscles are working hard because they're contracting,

0:34:03.120 --> 0:34:07.400
<v Speaker 3>they use up ATP, and in using up ATP, they

0:34:07.720 --> 0:34:14.000
<v Speaker 3>release or create Essentially by taking off phosphate, they release

0:34:14.120 --> 0:34:19.040
<v Speaker 3>a denazine, which is the adnizine part of adenizine tryphosphate ATP.

0:34:20.960 --> 0:34:25.960
<v Speaker 3>When adenizine levels in your brain become high, they bind

0:34:26.200 --> 0:34:29.319
<v Speaker 3>to a number of different adenizine receptors. There's a bunch

0:34:29.360 --> 0:34:32.760
<v Speaker 3>of different subtypes and they basically cause you to become

0:34:32.800 --> 0:34:36.279
<v Speaker 3>sleepy because if you think about it, if your brain

0:34:36.360 --> 0:34:38.560
<v Speaker 3>is working hard and using up a bunch of energy,

0:34:39.120 --> 0:34:42.359
<v Speaker 3>then your brain probably needs a rest. Right, So by

0:34:42.440 --> 0:34:46.439
<v Speaker 3>using up ATP, you increase the levels of adnazine, which

0:34:46.600 --> 0:34:50.240
<v Speaker 3>tells your brain by binding to these receptors, hey I'm tired,

0:34:50.520 --> 0:34:52.280
<v Speaker 3>I need a rest, Let's take a break.

0:34:52.920 --> 0:34:56.320
<v Speaker 1>Hum, Okay, which is why at the end of the day,

0:34:56.880 --> 0:34:59.160
<v Speaker 1>that build up makes you fall asleep and you get

0:34:59.200 --> 0:35:00.440
<v Speaker 1>that sleepy at the end.

0:35:00.040 --> 0:35:04.560
<v Speaker 3>If not, the only thing sleep is more complicated than that,

0:35:04.680 --> 0:35:10.839
<v Speaker 3>but that's one. That's one thing. Okay. So yes, So caffeine,

0:35:11.040 --> 0:35:15.799
<v Speaker 3>as it turns out, is an antagonist of adentizine receptors,

0:35:15.840 --> 0:35:20.440
<v Speaker 3>which means it blocks adentizine receptors. So if it blocks

0:35:20.480 --> 0:35:24.040
<v Speaker 3>the thing that makes you sleepy, it makes you feel awake.

0:35:24.760 --> 0:35:25.920
<v Speaker 2>Amazing question.

0:35:26.400 --> 0:35:32.080
<v Speaker 1>Okay, So wait, if you plotted the adenizine throughout the

0:35:32.200 --> 0:35:35.279
<v Speaker 1>day and like starting in the morning of like an

0:35:35.360 --> 0:35:37.440
<v Speaker 1>average day, or you did this and you averaged it

0:35:37.560 --> 0:35:40.600
<v Speaker 1>or whatever in the morning, would it also be high

0:35:40.600 --> 0:35:43.279
<v Speaker 1>because you're just waking up and you're not quite there? Like,

0:35:43.360 --> 0:35:46.120
<v Speaker 1>why does it? Why does caffeine make you wake up

0:35:46.120 --> 0:35:48.200
<v Speaker 1>in the morning? Like I could see why it would

0:35:48.280 --> 0:35:52.279
<v Speaker 1>throughout the day make you feel more awake as it

0:35:52.400 --> 0:35:55.200
<v Speaker 1>blocked those receptors, But why in the morning does it help?

0:35:55.680 --> 0:35:59.600
<v Speaker 3>Great question? So I don't fully know the answer to that.

0:35:59.640 --> 0:36:02.080
<v Speaker 3>I don't know. Maybe there's just a dentizine like leftover

0:36:02.239 --> 0:36:05.960
<v Speaker 3>residual or if just by blocking those receptors you prevent

0:36:06.000 --> 0:36:09.880
<v Speaker 3>any adentizine from binding. But I have seen some studies

0:36:09.880 --> 0:36:13.840
<v Speaker 3>that suggest that caffeine has greater effects if you're already

0:36:13.880 --> 0:36:17.160
<v Speaker 3>a little drowsy right, So if you're already tired and

0:36:17.200 --> 0:36:20.080
<v Speaker 3>then you drink caffeine, it has greater effects. When they've

0:36:20.080 --> 0:36:22.920
<v Speaker 3>done trials of like how alert are you, what's your

0:36:22.920 --> 0:36:25.880
<v Speaker 3>response time? Things like that, the effects are greater if

0:36:25.920 --> 0:36:29.239
<v Speaker 3>you're already drowsy rather than if you're already alert, if

0:36:29.280 --> 0:36:29.799
<v Speaker 3>that makes sense.

0:36:29.840 --> 0:36:34.319
<v Speaker 1>So there's like a maximum alertness almost and then so

0:36:34.440 --> 0:36:36.440
<v Speaker 1>like to get back to that maximum, you have to

0:36:36.440 --> 0:36:38.319
<v Speaker 1>be a little bit like coffee will help you get

0:36:38.360 --> 0:36:38.680
<v Speaker 1>to there.

0:36:38.920 --> 0:36:41.640
<v Speaker 3>I don't know, it's a little it's complicated, and this

0:36:41.800 --> 0:36:42.680
<v Speaker 3>is just the basics.

0:36:43.040 --> 0:36:45.840
<v Speaker 2>It makes sense though, because I feel like any more today,

0:36:45.880 --> 0:36:48.240
<v Speaker 2>caffeine in the morning just kind of levels me, whereas

0:36:48.280 --> 0:36:51.640
<v Speaker 2>caffeine at like two pm floors me. I'm like, oh,

0:36:51.760 --> 0:36:52.760
<v Speaker 2>let's get this done.

0:36:53.120 --> 0:36:57.560
<v Speaker 3>So another interesting point is that remember I said you

0:36:57.600 --> 0:37:01.239
<v Speaker 3>can become dependent where you can have withdrawal symptoms. When

0:37:01.280 --> 0:37:04.800
<v Speaker 3>you are a habitual user of caffeine, your body actually

0:37:04.920 --> 0:37:09.120
<v Speaker 3>upregulates the number of a dentisine receptors so that a

0:37:09.200 --> 0:37:13.080
<v Speaker 3>dentosine can still bind, so that caffeine is actually less effective,

0:37:13.080 --> 0:37:16.160
<v Speaker 3>which we see with so many different compounds, where you

0:37:16.280 --> 0:37:20.319
<v Speaker 3>basically like create tolerance to it. Your body finds a

0:37:20.320 --> 0:37:22.400
<v Speaker 3>way to get around this drug that you're giving it.

0:37:22.560 --> 0:37:27.719
<v Speaker 1>Right, how long does it take to build a dependence

0:37:28.360 --> 0:37:31.520
<v Speaker 1>or like to actually see those physiological long term changes.

0:37:32.760 --> 0:37:35.959
<v Speaker 3>Not very long, because you can have withdrawal symptoms after

0:37:36.120 --> 0:37:39.680
<v Speaker 3>just maybe like three or four days of chronic caffeine use.

0:37:40.440 --> 0:37:45.960
<v Speaker 3>But it usually only takes forty eight hours to go

0:37:46.000 --> 0:37:48.480
<v Speaker 3>through withdrawals, but for some people it can take up

0:37:48.480 --> 0:37:53.000
<v Speaker 3>to like nine days. It's very Caffeine's another thing that

0:37:53.080 --> 0:37:59.000
<v Speaker 3>like the effects of caffeine are very greatly depending on

0:37:59.120 --> 0:38:03.480
<v Speaker 3>like interpersonal differences in metabolism and things like that. So

0:38:03.520 --> 0:38:06.400
<v Speaker 3>there's a huge amount of variation in like the effect

0:38:06.480 --> 0:38:08.359
<v Speaker 3>that a single cup of coffee is going to have

0:38:08.440 --> 0:38:09.719
<v Speaker 3>on any given individual.

0:38:11.400 --> 0:38:15.560
<v Speaker 1>I have a question, Oh gosh, okay, okay, So in

0:38:15.640 --> 0:38:18.920
<v Speaker 1>terms of talking about withdrawal, why do we see some

0:38:18.960 --> 0:38:22.600
<v Speaker 1>of the symptoms we see, like when you have let's

0:38:22.600 --> 0:38:25.480
<v Speaker 1>if you have those the excess of receptors, like I

0:38:25.480 --> 0:38:27.960
<v Speaker 1>could see how you'd be sleepier than normal, ord be

0:38:28.000 --> 0:38:30.560
<v Speaker 1>more difficult to wake up. But why do I get

0:38:30.600 --> 0:38:33.719
<v Speaker 1>a massive headache and I feel like killing everyone around me?

0:38:34.160 --> 0:38:34.960
<v Speaker 2>Great question?

0:38:35.400 --> 0:38:37.840
<v Speaker 3>Okay, so let's talk about some of the other effects

0:38:37.880 --> 0:38:41.160
<v Speaker 3>of caffeine to be able to understand that things. I'm

0:38:41.280 --> 0:38:48.839
<v Speaker 3>very excited, that's perfect, okay. So the alertness and awakeness

0:38:49.280 --> 0:38:54.360
<v Speaker 3>that aspect, right, it's like hypervigilance, increased alertness, which leads

0:38:54.360 --> 0:38:59.239
<v Speaker 3>to things like faster response time, better driving. Okay, if

0:38:59.239 --> 0:39:01.880
<v Speaker 3>you're sleepy, caffeine does make you a better driver or

0:39:01.920 --> 0:39:04.720
<v Speaker 3>things like that. Those we can kind of all explain

0:39:04.800 --> 0:39:07.960
<v Speaker 3>from the whole adnozine receptor thing. But that's not the

0:39:07.960 --> 0:39:10.480
<v Speaker 3>only place that we have a dentosine receptors. Is not

0:39:10.560 --> 0:39:12.440
<v Speaker 3>just in those parts of our brain that have to

0:39:12.480 --> 0:39:16.359
<v Speaker 3>do with sleepiness, Okay. Adnazine has a lot of other

0:39:16.440 --> 0:39:20.880
<v Speaker 3>effects on our body. For example, there are adentisine receptors

0:39:20.880 --> 0:39:27.560
<v Speaker 3>in our heart that block electric signaling in our heart. So,

0:39:27.880 --> 0:39:30.759
<v Speaker 3>for example, if someone in the hospital has what we

0:39:30.800 --> 0:39:34.759
<v Speaker 3>call a superventricular tachycardia, so their heart is beating way, way,

0:39:34.760 --> 0:39:38.120
<v Speaker 3>way way too fast and out of proper rhythm. You

0:39:38.120 --> 0:39:41.640
<v Speaker 3>give them a denazine. It blocks all electric conduction to

0:39:41.680 --> 0:39:44.840
<v Speaker 3>their heart, stops their heart for a split second, and

0:39:44.880 --> 0:39:48.440
<v Speaker 3>then they can restart in normal sinus rhythm. So if

0:39:48.440 --> 0:39:51.800
<v Speaker 3>adnazine can stop and slow your heart rate, what do

0:39:51.880 --> 0:39:54.440
<v Speaker 3>you think caffeine can do if it blocks those receptors,

0:39:56.360 --> 0:40:00.360
<v Speaker 3>increase that heart rate. Yeah, okay, so that's an effect

0:40:00.360 --> 0:40:03.520
<v Speaker 3>that you mentioned, Matt, Right, you feel your heart rate. Okay,

0:40:05.120 --> 0:40:10.759
<v Speaker 3>So headaches adnozine has also effects not just on your heart,

0:40:11.040 --> 0:40:15.879
<v Speaker 3>but on your vasculature. In your brain, A denozine can

0:40:15.920 --> 0:40:20.640
<v Speaker 3>help vasodilate vessels to your brain, while in your peripheral

0:40:21.239 --> 0:40:25.120
<v Speaker 3>blood vessels it causes vasoconstriction. Don't ask me the details,

0:40:25.280 --> 0:40:27.880
<v Speaker 3>please why and it does do that?

0:40:28.160 --> 0:40:29.920
<v Speaker 2>That was my next question. Details.

0:40:30.320 --> 0:40:36.120
<v Speaker 3>So caffeine does the opposite. Caffeine causes vasoconstriction of your

0:40:36.160 --> 0:40:40.879
<v Speaker 3>cerebral blood vessels to your brain and vasodilation of your

0:40:40.920 --> 0:40:46.920
<v Speaker 3>peripheral blood vessels. Vasoconstriction is what a lot of headache

0:40:46.960 --> 0:40:50.480
<v Speaker 3>medications do because a lot of headaches are caused by

0:40:50.560 --> 0:40:54.120
<v Speaker 3>vasodilation increased pressure in your brain right from too much

0:40:54.160 --> 0:40:57.640
<v Speaker 3>blood flowing there. So if you have caffeine and can

0:40:57.719 --> 0:41:01.080
<v Speaker 3>vasoconstrict those blood vessels, caffeine is really helpful, and it's

0:41:01.120 --> 0:41:03.920
<v Speaker 3>in a lot of headache medication, right, Like, uh, what

0:41:03.960 --> 0:41:04.720
<v Speaker 3>do you call that stuff?

0:41:04.760 --> 0:41:05.160
<v Speaker 1>Et cetera.

0:41:05.840 --> 0:41:08.600
<v Speaker 3>Yeah, right, And there's been a lot of studies that

0:41:08.680 --> 0:41:12.080
<v Speaker 3>show like en sids with caffeine are more effective than

0:41:12.120 --> 0:41:15.160
<v Speaker 3>en sids alone for a lot of headaches. But on

0:41:15.200 --> 0:41:18.480
<v Speaker 3>the flip side, if you then take away that caffeine

0:41:18.480 --> 0:41:20.880
<v Speaker 3>that your brain is used to having, you're gonna have

0:41:20.960 --> 0:41:23.560
<v Speaker 3>increased blood flow to that brain. You're gonna have a headache.

0:41:25.160 --> 0:41:25.520
<v Speaker 1>Bone.

0:41:26.760 --> 0:41:28.680
<v Speaker 3>Wow, that's pretty fun, right.

0:41:29.080 --> 0:41:30.640
<v Speaker 1>What about my hollow bones?

0:41:31.280 --> 0:41:32.400
<v Speaker 3>Your hollow bones?

0:41:32.480 --> 0:41:35.200
<v Speaker 2>Okay, your bird stop it.

0:41:36.719 --> 0:41:40.040
<v Speaker 3>So I'm not sure this can fully explain the hollow

0:41:40.200 --> 0:41:47.120
<v Speaker 3>bones necessarily, but the jitteriness Okay, so this one's really fun.

0:41:47.600 --> 0:41:53.279
<v Speaker 3>A denizine in your brain also has interactions with dopamine

0:41:53.840 --> 0:41:58.239
<v Speaker 3>receptors and dopamine release. Okay, we've talked about dopamine a

0:41:58.320 --> 0:42:01.000
<v Speaker 3>number of times on the podcast, but dopamine is really

0:42:01.040 --> 0:42:06.120
<v Speaker 3>important both in mood, So more dopamine usually means more happier,

0:42:06.880 --> 0:42:10.839
<v Speaker 3>but too much dopamine can also mean like psychosis, so

0:42:10.880 --> 0:42:13.520
<v Speaker 3>we think that things like schizophrenia have to do with

0:42:13.680 --> 0:42:18.319
<v Speaker 3>too much dopamine. Okay, wow, But dopamine is also really

0:42:18.360 --> 0:42:23.960
<v Speaker 3>important in motor control. Right. So Parkinson's, for example, is

0:42:24.000 --> 0:42:28.360
<v Speaker 3>a problem where your basal ganglia doesn't produce dopamine properly

0:42:28.840 --> 0:42:31.920
<v Speaker 3>or doesn't respond to dopamine properly, so you end up

0:42:31.960 --> 0:42:38.839
<v Speaker 3>with slow movement and arresting tremor. Okay, So a denazine

0:42:39.280 --> 0:42:43.480
<v Speaker 3>normally is an antagonist of dopamine, so it blocks the

0:42:43.520 --> 0:42:48.600
<v Speaker 3>release of dopamine. Caffeine is an antagonist of a denazine,

0:42:48.719 --> 0:42:51.520
<v Speaker 3>so it increases the release of dopamine, so it can

0:42:51.560 --> 0:42:55.560
<v Speaker 3>cause those like tremors. It can increase muscle contraction. So

0:42:55.719 --> 0:42:58.279
<v Speaker 3>maybe that's part of it for you, Aaron and your

0:42:58.360 --> 0:43:03.480
<v Speaker 3>holow bone. It's why some people think that caffeine is

0:43:03.680 --> 0:43:08.520
<v Speaker 3>a performance enhancer in general, right, Like for athletic events,

0:43:09.640 --> 0:43:12.120
<v Speaker 3>people used to use caffeine. They still do, I'm sure

0:43:12.200 --> 0:43:15.040
<v Speaker 3>for like it's gonna make me run faster. There's not

0:43:15.160 --> 0:43:17.400
<v Speaker 3>a ton of data that says it actually does. It

0:43:17.440 --> 0:43:21.879
<v Speaker 3>really just delays exhaustion most likely. But you know, give

0:43:21.920 --> 0:43:23.680
<v Speaker 3>it to them if it makes them feel good.

0:43:25.880 --> 0:43:28.560
<v Speaker 2>I'm calling the Olympics. That's a performance enhancing drug.

0:43:29.160 --> 0:43:31.439
<v Speaker 3>You know, there used to be limits on how much

0:43:31.480 --> 0:43:34.400
<v Speaker 3>caffeine you could have in your bloodstream as an Olympic athlete.

0:43:34.480 --> 0:43:37.680
<v Speaker 1>Uh huh, how much could you have? Like what was.

0:43:39.560 --> 0:43:41.080
<v Speaker 3>That's like a question for you.

0:43:43.360 --> 0:43:47.840
<v Speaker 1>History. Oh, that's that's so fascinating and it makes so

0:43:47.960 --> 0:43:48.879
<v Speaker 1>much sense.

0:43:49.120 --> 0:43:52.080
<v Speaker 3>And it also can kind of get at Matt, why

0:43:52.200 --> 0:43:56.680
<v Speaker 3>you said caffeine makes you feel happy? Right. Caffeine can

0:43:56.760 --> 0:44:01.040
<v Speaker 3>also increase serotonin levels in your brain, so some people

0:44:01.080 --> 0:44:04.360
<v Speaker 3>think that it can maybe help with depression. There's not

0:44:04.440 --> 0:44:08.480
<v Speaker 3>a ton of great evidence for that because we've kind

0:44:08.480 --> 0:44:12.480
<v Speaker 3>of already talked about a lot of these symptoms heart palpitations,

0:44:13.280 --> 0:44:16.200
<v Speaker 3>you know, feeling like you're jittery. That sounds a lot

0:44:16.400 --> 0:44:22.160
<v Speaker 3>like an anxiety. Yes, so caffeine can actually exacerbate anxiety,

0:44:22.280 --> 0:44:24.799
<v Speaker 3>especially in people who already have anxiety or who are

0:44:24.840 --> 0:44:26.240
<v Speaker 3>prone to panic attacks.

0:44:27.239 --> 0:44:29.560
<v Speaker 2>I've I've definitely had periods of my life where I've

0:44:29.560 --> 0:44:32.680
<v Speaker 2>had to avoid it for that reason. And that's what

0:44:32.800 --> 0:44:34.440
<v Speaker 2>when you were going through the history, I was like,

0:44:34.600 --> 0:44:36.839
<v Speaker 2>I want to meet the first person to overdo it

0:44:36.920 --> 0:44:37.560
<v Speaker 2>on coffee.

0:44:37.760 --> 0:44:39.960
<v Speaker 3>Oh yeah, yeah.

0:44:39.600 --> 0:44:43.239
<v Speaker 1>Yeah, somebody I can't remember who it was used to drink.

0:44:43.280 --> 0:44:45.760
<v Speaker 1>This isn't coffee, but they would drink around fifty cups

0:44:45.760 --> 0:44:46.879
<v Speaker 1>of hot chocolate a day.

0:44:47.360 --> 0:44:49.640
<v Speaker 3>Nope, Oh bad idea.

0:44:50.680 --> 0:44:53.439
<v Speaker 2>Oh okay, I just got an indigestion thinking about that.

0:44:53.600 --> 0:44:56.120
<v Speaker 1>Speaking of why does coffee make you poop?

0:44:57.080 --> 0:44:57.400
<v Speaker 3>Okay?

0:44:58.520 --> 0:45:01.600
<v Speaker 2>Please tell me no poop and pee.

0:45:01.640 --> 0:45:04.160
<v Speaker 3>Right, So people say caffeine's diuretic. It makes you pee,

0:45:04.239 --> 0:45:07.400
<v Speaker 3>and it makes you poop. I saw some things that

0:45:07.440 --> 0:45:11.520
<v Speaker 3>suggest that maybe it can have some like pro motility

0:45:11.560 --> 0:45:16.040
<v Speaker 3>effects on your bowels, but in general, my understanding is

0:45:16.040 --> 0:45:20.000
<v Speaker 3>that that's mostly a timing association. Most people poop in

0:45:20.040 --> 0:45:23.400
<v Speaker 3>the morning. Most people have coffee in the morning. You know,

0:45:23.560 --> 0:45:25.799
<v Speaker 3>anytime you eat something that's gonna kind of wake your

0:45:25.840 --> 0:45:28.520
<v Speaker 3>bowels up, get them moving, so then you can have

0:45:28.560 --> 0:45:33.920
<v Speaker 3>a poop. The diuretic effect so making you pee. There

0:45:34.000 --> 0:45:37.840
<v Speaker 3>is some evidence that at like very high levels, there

0:45:37.960 --> 0:45:43.040
<v Speaker 3>might be some diuresis from caffeine ingestion, but in general,

0:45:43.440 --> 0:45:47.280
<v Speaker 3>especially at levels that you would consume normally, it's really

0:45:47.600 --> 0:45:49.920
<v Speaker 3>it's a negligible effect. So it's really like, are you

0:45:50.000 --> 0:45:53.080
<v Speaker 3>drinking a liquid then you'll have to pee.

0:45:53.920 --> 0:45:56.799
<v Speaker 2>So the whole thing about like coffee dehydrating the heck

0:45:56.800 --> 0:45:59.240
<v Speaker 2>out of you is probably blown out of proportion.

0:45:59.560 --> 0:46:03.000
<v Speaker 3>Yeah, I think it's it again with the tolerance thing.

0:46:03.160 --> 0:46:06.600
<v Speaker 3>If you never drink caffeine ever, then maybe it might

0:46:06.640 --> 0:46:09.160
<v Speaker 3>have a little bit more of a diuretic effect than

0:46:09.280 --> 0:46:13.760
<v Speaker 3>if you drink coffee regularly. But in general, it doesn't

0:46:13.760 --> 0:46:16.239
<v Speaker 3>really have as strong of a diuretic effect as we

0:46:16.360 --> 0:46:16.879
<v Speaker 3>used to think.

0:46:17.600 --> 0:46:21.400
<v Speaker 1>Man, I am shocked about it not having a direct

0:46:21.480 --> 0:46:22.240
<v Speaker 1>link to pooping.

0:46:22.640 --> 0:46:25.480
<v Speaker 3>Yeah, there was only like one paper that I saw

0:46:26.080 --> 0:46:29.000
<v Speaker 3>that even mentioned its effects on GI. So I don't

0:46:29.000 --> 0:46:33.080
<v Speaker 3>even know, like how real. I think it's largely timing.

0:46:33.120 --> 0:46:35.960
<v Speaker 3>You know, you eat something, you drink something that wakes

0:46:36.040 --> 0:46:42.960
<v Speaker 3>up your bowels like you. So, even coffee has calories, right,

0:46:43.000 --> 0:46:45.840
<v Speaker 3>and it's it's it's sending the signals to your stomach.

0:46:45.960 --> 0:46:50.240
<v Speaker 3>It's sent it's activating those stretch receptors. It's it's got

0:46:50.400 --> 0:46:52.040
<v Speaker 3>amino acids, it's.

0:46:51.920 --> 0:46:55.239
<v Speaker 1>Got I thought coffee didn't have calories.

0:46:55.080 --> 0:46:57.920
<v Speaker 3>But it has stuff in there, right, It's not just

0:46:57.960 --> 0:47:04.840
<v Speaker 3>like drinking water. Right, there's I don't know what coffee oils,

0:47:04.960 --> 0:47:10.879
<v Speaker 3>no acids, other compounds that are going to stimulate your

0:47:11.200 --> 0:47:13.320
<v Speaker 3>plus also you drink it with half and half aarin.

0:47:13.520 --> 0:47:17.520
<v Speaker 2>Sometimes it's also it's got to be negligible because all

0:47:17.640 --> 0:47:20.799
<v Speaker 2>like the fasting intermittent fasting stuff is like Coffee's fine,

0:47:20.840 --> 0:47:21.920
<v Speaker 2>don't worry about coffee.

0:47:22.200 --> 0:47:26.080
<v Speaker 3>Yeah, it's true. Yeah, Oh you want to know a

0:47:26.200 --> 0:47:30.560
<v Speaker 3>fun side note use of caffeine. I learned this while researching.

0:47:30.560 --> 0:47:37.120
<v Speaker 3>I think it's fascinating. Caffeine is used in premature newborns

0:47:37.719 --> 0:47:42.400
<v Speaker 3>to help prevent apnea, so like to make them breathe better,

0:47:42.560 --> 0:47:47.239
<v Speaker 3>essentially because it helps your diaphragm, It helps their diaphragm

0:47:47.239 --> 0:47:51.600
<v Speaker 3>to be more active and prevent complications from not breathing properly.

0:47:51.719 --> 0:47:54.560
<v Speaker 3>So not just caffeine, but another So caffeine is in

0:47:54.560 --> 0:47:57.840
<v Speaker 3>a class of compounds called methyl xantheenes, and there's another

0:47:58.080 --> 0:48:01.319
<v Speaker 3>methyl xanthine that we actually use to treat asthma, called

0:48:01.360 --> 0:48:03.880
<v Speaker 3>theophilin interesting.

0:48:04.400 --> 0:48:06.200
<v Speaker 2>Yeah, that's amazing, I know.

0:48:06.600 --> 0:48:08.960
<v Speaker 1>So one of the things that I was always told

0:48:09.000 --> 0:48:12.319
<v Speaker 1>growing up, because I loved coffee as a kid, was

0:48:12.320 --> 0:48:14.799
<v Speaker 1>that it would stunt my growth. And then I grew

0:48:14.840 --> 0:48:17.560
<v Speaker 1>up to be the shortest by far of everyone in

0:48:17.560 --> 0:48:20.960
<v Speaker 1>my family, and so I've always was it.

0:48:21.160 --> 0:48:23.880
<v Speaker 3>That's it, Aaron, No, it's just bad luck.

0:48:25.080 --> 0:48:29.160
<v Speaker 1>There's life, my excuse me. Oh sorry, Wow.

0:48:31.400 --> 0:48:33.439
<v Speaker 2>Your genes are terrible and you have coffee to fight.

0:48:36.280 --> 0:48:41.240
<v Speaker 3>There's no association with a short stature and caffeine intake.

0:48:41.600 --> 0:48:44.759
<v Speaker 1>Okay, what about any of the other studies. Has there

0:48:44.800 --> 0:48:49.640
<v Speaker 1>been any association between caffeine intake and negative outcome in

0:48:49.760 --> 0:48:52.160
<v Speaker 1>anything or any positive outcome.

0:48:52.719 --> 0:48:54.759
<v Speaker 3>So there's been a lot of talk about whether it

0:48:54.800 --> 0:48:58.680
<v Speaker 3>has effects on your cardiovascular disease or increased risk of

0:48:58.760 --> 0:49:03.040
<v Speaker 3>death from cardiovascular disease. There's not really an association there.

0:49:04.560 --> 0:49:07.840
<v Speaker 3>There's some people that say it can increase your blood pressure,

0:49:08.440 --> 0:49:12.880
<v Speaker 3>which for someone who never drinks caffeine, if they drink caffeine,

0:49:12.960 --> 0:49:15.920
<v Speaker 3>you can see maybe like a ten point bump in

0:49:15.960 --> 0:49:20.920
<v Speaker 3>their blood pressure transiently. But if you drink caffeine regularly,

0:49:21.080 --> 0:49:24.280
<v Speaker 3>it has pretty negligible effects overall on your blood pressure.

0:49:25.320 --> 0:49:28.719
<v Speaker 3>Basically all the things that we used to think caffeine

0:49:28.760 --> 0:49:32.040
<v Speaker 3>is just so terrible. It has all these negative effects,

0:49:32.719 --> 0:49:35.800
<v Speaker 3>it doesn't actually have a lot of association a lot

0:49:35.840 --> 0:49:38.040
<v Speaker 3>of the studies that used to show it, because the

0:49:38.080 --> 0:49:40.680
<v Speaker 3>problem with caffeine is that most of our studies about

0:49:40.680 --> 0:49:45.400
<v Speaker 3>caffeine are coffee drinkers, right, which means they're dietary studies,

0:49:45.400 --> 0:49:47.759
<v Speaker 3>which means they're really hard to do. There's a lot

0:49:47.800 --> 0:49:49.880
<v Speaker 3>of different ways you can end up with biases like

0:49:49.960 --> 0:49:53.800
<v Speaker 3>recall bias, but then there's also a lot of interactions

0:49:53.840 --> 0:49:58.280
<v Speaker 3>in terms of who drinks coffee. So in some cases

0:49:58.360 --> 0:50:02.360
<v Speaker 3>it's actually people who are generally healthier that are drinking

0:50:02.360 --> 0:50:04.880
<v Speaker 3>more coffee because they have access to it and they

0:50:04.920 --> 0:50:08.360
<v Speaker 3>can afford it. But on the flip side, there's also

0:50:08.480 --> 0:50:12.080
<v Speaker 3>associations with things like smoking and increased coffee drink if

0:50:12.120 --> 0:50:13.920
<v Speaker 3>you think about going out for a smoke break and

0:50:13.960 --> 0:50:17.920
<v Speaker 3>a cup of coffee, et cetera. And so in the past,

0:50:18.000 --> 0:50:20.640
<v Speaker 3>a lot of studies have kind of confounded especially the

0:50:20.680 --> 0:50:23.799
<v Speaker 3>effects of cigarette smoking and coffee drinking, which is why

0:50:23.880 --> 0:50:25.799
<v Speaker 3>for a while, I think a lot of it was

0:50:25.840 --> 0:50:28.040
<v Speaker 3>like coffee's terrible for you, and then it was like

0:50:28.080 --> 0:50:30.400
<v Speaker 3>coffee will save you. And now it's kind of just like,

0:50:30.920 --> 0:50:33.919
<v Speaker 3>if coffee makes you feel more awake, then have some coffee.

0:50:35.719 --> 0:50:38.360
<v Speaker 1>What about the sleep impacts.

0:50:38.600 --> 0:50:42.239
<v Speaker 3>So caffeine increases your sleep latency, which means it takes

0:50:42.280 --> 0:50:46.520
<v Speaker 3>you longer to be able to fall asleep, and subjectively,

0:50:46.600 --> 0:50:49.720
<v Speaker 3>people say that after drinking caffeine they feel less rested

0:50:49.760 --> 0:50:52.279
<v Speaker 3>when they wake up, so they say that it interferes

0:50:52.280 --> 0:50:55.640
<v Speaker 3>with their quality of their sleep. In terms of how

0:50:55.680 --> 0:50:58.200
<v Speaker 3>long the effects of caffeine last in your body, it

0:50:58.239 --> 0:51:01.280
<v Speaker 3>can vary quite a lot, but on average the half

0:51:01.360 --> 0:51:04.520
<v Speaker 3>life is like three to seven hours, so if you

0:51:04.600 --> 0:51:06.520
<v Speaker 3>drink a cup of coffee in the morning, it should

0:51:06.560 --> 0:51:08.719
<v Speaker 3>be well gone by the time you get to bedtime.

0:51:09.000 --> 0:51:10.520
<v Speaker 3>But if you have a cup of coffee at like

0:51:10.560 --> 0:51:13.280
<v Speaker 3>four in the afternoon, then yeah, you'll probably have still

0:51:13.360 --> 0:51:15.359
<v Speaker 3>like half of that in your bloodstream by the time

0:51:15.360 --> 0:51:15.879
<v Speaker 3>you go to bed.

0:51:16.400 --> 0:51:19.160
<v Speaker 2>Okay, yeah, my cutoff is three.

0:51:19.719 --> 0:51:22.320
<v Speaker 1>Yeah, yeah, my cutoff is like ten am.

0:51:23.120 --> 0:51:28.320
<v Speaker 3>I chug like a triple espresso and fall asleep right after.

0:51:29.640 --> 0:51:32.799
<v Speaker 3>And that's the thing. There's a lot, Yeah, there is

0:51:32.840 --> 0:51:37.440
<v Speaker 3>a lot of variation, individual variation in the metabolism of caffeine.

0:51:38.000 --> 0:51:40.200
<v Speaker 3>And then of course there's tolerance effects on top of

0:51:40.239 --> 0:51:40.520
<v Speaker 3>all that.

0:51:40.719 --> 0:51:44.720
<v Speaker 1>So I think it's it is interesting, like there's still

0:51:44.760 --> 0:51:48.160
<v Speaker 1>this association that we have with like, oh, I'm I'm

0:51:48.320 --> 0:51:52.080
<v Speaker 1>giving up caffeine. It's like a very puritanical kind of like, yeah,

0:51:52.200 --> 0:51:54.960
<v Speaker 1>glimpse of like this thing that you know.

0:51:56.239 --> 0:51:58.600
<v Speaker 3>Other thing i'd like to say, because I get this

0:51:58.719 --> 0:52:03.399
<v Speaker 3>question a lot from like lens caffeine and pregnancy. For

0:52:03.520 --> 0:52:05.520
<v Speaker 3>a long time, it was like, no, you can't have

0:52:05.600 --> 0:52:09.920
<v Speaker 3>caffeine if you're pregnant. There's been really no good studies

0:52:09.920 --> 0:52:12.880
<v Speaker 3>that show that small amounts of coffee like up to

0:52:12.960 --> 0:52:15.560
<v Speaker 3>three hundred milligrams of caffeine, which is about like three

0:52:15.719 --> 0:52:18.359
<v Speaker 3>two to three cups depending on what size your cup is,

0:52:19.280 --> 0:52:23.560
<v Speaker 3>don't really have any effects adverse effects on fetus or

0:52:23.719 --> 0:52:30.520
<v Speaker 3>mom or anything. So yeah. So, however, in the third

0:52:30.640 --> 0:52:34.960
<v Speaker 3>trimester of pregnancy, the half life of caffeine is increased

0:52:35.080 --> 0:52:37.640
<v Speaker 3>quite a lot longer, which is super interesting, and in

0:52:37.719 --> 0:52:42.080
<v Speaker 3>newborns it's super long, like eighty hours. It can be

0:52:42.440 --> 0:52:45.239
<v Speaker 3>where caffeine like, that's the half life for caffeine, which

0:52:45.280 --> 0:52:49.840
<v Speaker 3>is so interesting. Don't ask me why. Livers ooh man.

0:52:50.200 --> 0:52:55.560
<v Speaker 1>I've also read that taking oral contraceptives increases the half

0:52:55.600 --> 0:52:57.080
<v Speaker 1>life of caffeine in the body.

0:52:57.520 --> 0:53:01.440
<v Speaker 3>It makes sense because the so caffeine is metabolized by

0:53:01.440 --> 0:53:06.920
<v Speaker 3>your liver, and oral contraceptives, especially ones with estrogen, are

0:53:07.000 --> 0:53:09.799
<v Speaker 3>going to also have a lot of interactions with your

0:53:09.840 --> 0:53:13.200
<v Speaker 3>liver and with the enzymes that potentially metabolize caffeine. So

0:53:13.520 --> 0:53:15.400
<v Speaker 3>I don't know for sure, but I wouldn't be surprised

0:53:15.400 --> 0:53:18.920
<v Speaker 3>if that's why your half life of caffeine increases in

0:53:18.960 --> 0:53:22.160
<v Speaker 3>third trimester pregnancy when your hormones are going wild.

0:53:24.360 --> 0:53:26.800
<v Speaker 2>Interesting, that's wild.

0:53:27.640 --> 0:53:30.000
<v Speaker 3>That was fun, guys. I'm glad you asked me some

0:53:30.040 --> 0:53:32.799
<v Speaker 3>many questions because my notes were not organized. But I

0:53:32.840 --> 0:53:34.000
<v Speaker 3>feel like that was fun.

0:53:34.960 --> 0:53:37.120
<v Speaker 1>I got over eager and I couldn't start learning.

0:53:39.080 --> 0:53:40.680
<v Speaker 2>And what's amazing is how much of this I've just

0:53:40.760 --> 0:53:42.799
<v Speaker 2>kind of taken with me and like held on, like, oh,

0:53:42.840 --> 0:53:46.160
<v Speaker 2>this is what caffeine to never realized how on the

0:53:46.160 --> 0:53:47.919
<v Speaker 2>fence at best. Some of this is.

0:53:48.320 --> 0:53:51.680
<v Speaker 3>Yeah, yeah, And it's also I will say, it's really

0:53:51.719 --> 0:53:54.720
<v Speaker 3>really difficult too, because a lot of our data about

0:53:54.760 --> 0:53:58.960
<v Speaker 3>caffeine comes from studies on coffee, and coffee is not

0:53:59.239 --> 0:54:02.960
<v Speaker 3>just caffeine. There's so many other compounds in coffee beans,

0:54:02.960 --> 0:54:05.640
<v Speaker 3>there's so many other compounds in tea leaves that are

0:54:05.680 --> 0:54:10.080
<v Speaker 3>different from coffee beans. So it is really difficult to

0:54:10.360 --> 0:54:14.359
<v Speaker 3>fully get a handle on the exact effects of caffeine

0:54:14.400 --> 0:54:21.799
<v Speaker 3>per se on these various processes. So Matt, can you

0:54:21.840 --> 0:54:25.839
<v Speaker 3>please tell us why on earth would plants make such

0:54:25.840 --> 0:54:29.040
<v Speaker 3>a substance and what is it good for? Irl?

0:54:30.600 --> 0:54:33.200
<v Speaker 2>Amazing question. I'm so happy to be here to talk

0:54:33.239 --> 0:54:33.680
<v Speaker 2>about this.

0:54:34.560 --> 0:54:36.839
<v Speaker 3>We'll take a quick break and then I want you

0:54:36.880 --> 0:54:38.160
<v Speaker 3>to tell us all about it.

0:55:10.960 --> 0:55:13.680
<v Speaker 1>Okay, great, Matt, that's with the good stuff.

0:55:13.960 --> 0:55:19.000
<v Speaker 2>Yeah, yes, So yet another fascinating dive down the literature

0:55:19.040 --> 0:55:21.440
<v Speaker 2>hole on this one, and it was never as simple

0:55:21.440 --> 0:55:23.560
<v Speaker 2>as I ever expected to be. So thank you again

0:55:23.640 --> 0:55:26.600
<v Speaker 2>for forcing me to look at this, especially considering how

0:55:26.640 --> 0:55:31.040
<v Speaker 2>dependent we'll say I am on this product. So, as

0:55:31.080 --> 0:55:35.120
<v Speaker 2>Aaron established in the beginning, more than just coffee produces caffeine.

0:55:35.360 --> 0:55:38.680
<v Speaker 2>I keep seeing this number around sixty different species tossed around,

0:55:38.719 --> 0:55:40.400
<v Speaker 2>but I did that whole web of science thing and

0:55:40.440 --> 0:55:42.879
<v Speaker 2>traced it back, and it's just something that someone through

0:55:42.880 --> 0:55:46.719
<v Speaker 2>out there they cited like a vascular flora of the tropics,

0:55:47.080 --> 0:55:49.880
<v Speaker 2>and just kind of picked it out. And basically what

0:55:49.960 --> 0:55:52.200
<v Speaker 2>we're gonna come down to you here is that certainly

0:55:52.480 --> 0:55:56.160
<v Speaker 2>far more plants than just sixty species do this. But

0:55:56.200 --> 0:55:58.520
<v Speaker 2>we generally only tend to look at things that interest

0:55:58.680 --> 0:56:03.040
<v Speaker 2>or have it used to us in some way, so food, drink, medicine, caffeine, tea, chocolate,

0:56:03.080 --> 0:56:06.440
<v Speaker 2>that sort of stuff. But again, as we've established, some

0:56:06.480 --> 0:56:08.680
<v Speaker 2>of the most prominent ones are very familiar to us.

0:56:08.680 --> 0:56:11.120
<v Speaker 2>So the genus Coffea, which is the coffee plant, and

0:56:11.200 --> 0:56:15.120
<v Speaker 2>all of its relatives, theobroma which is chocolate citrus, actually

0:56:15.160 --> 0:56:18.160
<v Speaker 2>produces a fair amount of caffeine. Camellia, which is the

0:56:18.200 --> 0:56:20.560
<v Speaker 2>genus for Tea cola, which is the genus for the

0:56:20.600 --> 0:56:23.000
<v Speaker 2>cola tree, which has gone on to give us a

0:56:23.040 --> 0:56:25.759
<v Speaker 2>lot of soft drink flavoring. I see a hand raised here.

0:56:25.960 --> 0:56:28.719
<v Speaker 3>Yep, sorry, does that mean like oranges.

0:56:29.800 --> 0:56:32.960
<v Speaker 2>Not within the orange itself. We'll circle back to that though,

0:56:32.960 --> 0:56:37.600
<v Speaker 2>but yes, yeah, all citrus do this on some level. Okay,

0:56:37.680 --> 0:56:40.600
<v Speaker 2>So guarana, which is the genus Pollinia, and you'll notice

0:56:40.640 --> 0:56:44.800
<v Speaker 2>guarana is a common ingredient within a lot of energy drinks,

0:56:44.800 --> 0:56:48.720
<v Speaker 2>because there's other compounds related to caffeine that have stimulatory effects.

0:56:48.920 --> 0:56:51.160
<v Speaker 2>And then a lot of Holly's, which if you've ever

0:56:51.320 --> 0:56:53.480
<v Speaker 2>drank you've both been in Central America, you're but mate,

0:56:55.040 --> 0:56:57.799
<v Speaker 2>which comes from a halley. So there's other again, other

0:56:57.840 --> 0:57:01.279
<v Speaker 2>stimulants within that, but caffeine is a major component of it.

0:57:01.320 --> 0:57:04.400
<v Speaker 2>And so those are just the ones that have economic

0:57:04.480 --> 0:57:06.120
<v Speaker 2>use to us and that we study the most. But again,

0:57:06.160 --> 0:57:08.160
<v Speaker 2>this is something that's prevalent in a lot of different

0:57:08.160 --> 0:57:10.960
<v Speaker 2>plant families and within those a lot of different species,

0:57:10.960 --> 0:57:14.040
<v Speaker 2>which is amazing and the coolest part about it is

0:57:14.080 --> 0:57:17.720
<v Speaker 2>that there is actually more than one way to synthesize caffeine.

0:57:17.720 --> 0:57:20.920
<v Speaker 2>If you're a plant, all of it involves alkaloid chemistry,

0:57:20.960 --> 0:57:24.440
<v Speaker 2>which caffeine is a type of alkaloid, and it tends

0:57:24.480 --> 0:57:28.320
<v Speaker 2>to rely on, as with any alkaloid production, high nitrogen

0:57:28.360 --> 0:57:30.880
<v Speaker 2>in the soil. So you generally will find these sorts

0:57:30.880 --> 0:57:33.560
<v Speaker 2>of species in rich soils because you need a lot

0:57:33.600 --> 0:57:38.360
<v Speaker 2>of nitrogen to build alkaloids. And that's kind of cool.

0:57:38.400 --> 0:57:41.000
<v Speaker 2>You can look at something about the habitat that has

0:57:41.200 --> 0:57:44.280
<v Speaker 2>allowed the evolution or at least selection to work on

0:57:44.360 --> 0:57:47.080
<v Speaker 2>the evolution of these compounds. So the question then becomes,

0:57:47.360 --> 0:57:50.520
<v Speaker 2>why is it there? Nothing in nature is done wastefully.

0:57:50.600 --> 0:57:53.400
<v Speaker 2>There's always some sort of function in there. Well, it

0:57:53.520 --> 0:57:56.720
<v Speaker 2>just so happens that researchers at the University of Buffalo,

0:57:56.720 --> 0:58:00.120
<v Speaker 2>which is mi alma mater, we're studying the genus coffee,

0:58:00.200 --> 0:58:03.240
<v Speaker 2>and they found that there are multiple genes involved in

0:58:03.280 --> 0:58:06.280
<v Speaker 2>the synthesis of caffeine and that they did not arise

0:58:06.720 --> 0:58:14.520
<v Speaker 2>all at once. What. Yeah, So genes duplicate a lot

0:58:14.560 --> 0:58:17.120
<v Speaker 2>in the plant world. It is not nearly as detrimental

0:58:17.160 --> 0:58:20.920
<v Speaker 2>to have ploity events in plants as it is most animals.

0:58:21.040 --> 0:58:23.800
<v Speaker 2>I would assume, at least on the vertebrate spectrum of things.

0:58:24.360 --> 0:58:29.200
<v Speaker 2>So ploidy is essentially a copying or duplication of the chromosomes.

0:58:29.240 --> 0:58:32.400
<v Speaker 2>So you can have diploidy, which means there's double the

0:58:32.400 --> 0:58:35.920
<v Speaker 2>amount of chromosomes, triploidy and so forth, and that's really

0:58:35.960 --> 0:58:38.520
<v Speaker 2>common in plants, and it's a very important way in

0:58:38.560 --> 0:58:42.959
<v Speaker 2>which plants evolve and specie and you go about doing

0:58:43.000 --> 0:58:47.240
<v Speaker 2>all the amazing chemistry that they do. And within just

0:58:47.440 --> 0:58:51.800
<v Speaker 2>coffee alone, the genus Caffea, the genes that are involved

0:58:51.800 --> 0:58:55.280
<v Speaker 2>in the production of caffeine have duplicated multiple times throughout

0:58:55.280 --> 0:58:58.680
<v Speaker 2>the history of this genus. And what's amazing is that,

0:58:58.800 --> 0:59:02.320
<v Speaker 2>like in the creation, it's literature that the propaganda that

0:59:02.360 --> 0:59:05.040
<v Speaker 2>goes out they use this to say, there's no way

0:59:05.040 --> 0:59:08.919
<v Speaker 2>this could have happened, because every step in the way

0:59:09.040 --> 0:59:12.560
<v Speaker 2>is important. You can't have this irreducibly complex system without

0:59:12.600 --> 0:59:15.320
<v Speaker 2>there being a creator. But when you actually look at

0:59:15.360 --> 0:59:18.800
<v Speaker 2>every step, every gene duplication, every mutation that led to

0:59:18.880 --> 0:59:22.240
<v Speaker 2>the process, every compound that is the end result of

0:59:22.280 --> 0:59:26.600
<v Speaker 2>that has a function for the plant. It is always bitter,

0:59:26.720 --> 0:59:29.000
<v Speaker 2>and it's always stored in an area in which will

0:59:29.040 --> 0:59:34.440
<v Speaker 2>prevent herbivery. I guess, and so every every step of

0:59:34.520 --> 0:59:38.680
<v Speaker 2>the way, every precursor compound is bitter and toxic to

0:59:38.760 --> 0:59:41.200
<v Speaker 2>the exact kind of animals that want to nibble on

0:59:41.240 --> 0:59:41.840
<v Speaker 2>these plants.

0:59:43.080 --> 0:59:44.720
<v Speaker 1>It's beautiful, it's.

0:59:46.320 --> 0:59:48.320
<v Speaker 2>It's mind blowing just to kind of see, how like,

0:59:48.440 --> 0:59:50.479
<v Speaker 2>and you look at these papers and you do see

0:59:50.520 --> 0:59:53.080
<v Speaker 2>these chemical I just like looking at them. I don't

0:59:53.160 --> 0:59:55.480
<v Speaker 2>understand them to save my life, but it is amazing

0:59:55.680 --> 0:59:57.760
<v Speaker 2>that every one of these compounds, every step of the

0:59:57.760 --> 1:00:00.920
<v Speaker 2>process has an anti herbivery fun which brings us to

1:00:01.000 --> 1:00:05.200
<v Speaker 2>the main function of caffeine for plants. The primary function

1:00:05.320 --> 1:00:08.240
<v Speaker 2>or role that it's playing is against as a defense

1:00:08.280 --> 1:00:13.080
<v Speaker 2>against herbivy and pathogens, which shouldn't surprise you. So many

1:00:13.120 --> 1:00:15.200
<v Speaker 2>of the chemicals within the plant world that we like

1:00:15.240 --> 1:00:18.200
<v Speaker 2>to utilize have their origins and keeping something from attacking

1:00:18.280 --> 1:00:22.400
<v Speaker 2>or eating them. And so, as Aaron already mentioned, there's

1:00:22.440 --> 1:00:24.919
<v Speaker 2>a lot of methyls anthenes. And the way that they've

1:00:25.000 --> 1:00:27.320
<v Speaker 2>kind of come to this conclusion is that they're able

1:00:27.360 --> 1:00:29.200
<v Speaker 2>to kind of turn these genes on, or at least

1:00:29.240 --> 1:00:32.000
<v Speaker 2>insert them into crop species like beats that don't normally

1:00:32.080 --> 1:00:35.760
<v Speaker 2>produce caffeine, and every time they induce caffeine production in

1:00:35.800 --> 1:00:42.320
<v Speaker 2>a crop species, it has significantly less herbivaly than their relatives,

1:00:42.400 --> 1:00:44.880
<v Speaker 2>the clones that do not have caffeine production.

1:00:45.840 --> 1:00:49.880
<v Speaker 1>So yeah, are they inserted in? Like is that one

1:00:49.880 --> 1:00:52.680
<v Speaker 1>of the strategies to create like you know as like

1:00:52.760 --> 1:00:56.840
<v Speaker 1>a natural pesticide GMO pesticide plant it.

1:00:57.400 --> 1:01:00.000
<v Speaker 2>That is totally the motivation for doing this. I think

1:01:00.120 --> 1:01:03.240
<v Speaker 2>the complication then becomes is keeping it from being expressed

1:01:03.240 --> 1:01:05.000
<v Speaker 2>in tissues. You don't want it, So I don't want

1:01:05.000 --> 1:01:06.880
<v Speaker 2>to beat that's going to keep me up all night, right,

1:01:07.600 --> 1:01:09.800
<v Speaker 2>and so it's a cheap way to study this. But

1:01:10.000 --> 1:01:12.400
<v Speaker 2>in terms of the motivation behind a lot of these studies,

1:01:12.440 --> 1:01:14.120
<v Speaker 2>it is trying to figure out how to get say

1:01:14.160 --> 1:01:17.480
<v Speaker 2>follier genes to express caffeine production as a quick and

1:01:17.520 --> 1:01:20.480
<v Speaker 2>easy way because even at low concentrations that you would

1:01:20.520 --> 1:01:24.680
<v Speaker 2>find in nature, these have a pesticidal effect, which is

1:01:24.720 --> 1:01:28.200
<v Speaker 2>pretty cool. Like, even at low doses, it's keeping these

1:01:28.240 --> 1:01:29.720
<v Speaker 2>things from being eaten.

1:01:30.240 --> 1:01:36.840
<v Speaker 1>Wow, So caffeine is in so many different plant species

1:01:37.000 --> 1:01:41.080
<v Speaker 1>all over the tropics naturally, like, so does that mean

1:01:41.080 --> 1:01:45.320
<v Speaker 1>that it evolved separately or into like in these convergent

1:01:45.360 --> 1:01:51.320
<v Speaker 1>evolution basically events is caffeine like a simple molecule or

1:01:51.320 --> 1:01:55.880
<v Speaker 1>like a relatively simple molecule that it had, Like why caffeine?

1:01:56.320 --> 1:01:59.920
<v Speaker 1>Like why like why that one particular compound? You know

1:02:00.000 --> 1:02:01.680
<v Speaker 1>what I mean? Do you know what I'm asking?

1:02:01.760 --> 1:02:04.760
<v Speaker 2>No great question? Yeah, yeah, and so yes to answer

1:02:04.760 --> 1:02:07.120
<v Speaker 2>your question, it is independent evolution. I mean even if

1:02:07.160 --> 1:02:10.000
<v Speaker 2>we just look at the families that we have listed already,

1:02:10.640 --> 1:02:14.280
<v Speaker 2>Caffeine or coffee is in ruby ac. We have chocolate

1:02:14.320 --> 1:02:16.960
<v Speaker 2>which is now malvasy, it's a mallow. We have the

1:02:17.000 --> 1:02:19.560
<v Speaker 2>Holly's which is aqua fully acy. They're their own family

1:02:19.680 --> 1:02:23.959
<v Speaker 2>we have. You know, it's widespread and independent in terms

1:02:24.000 --> 1:02:27.440
<v Speaker 2>of the complexity. I think it's a pretty complex molecule.

1:02:27.560 --> 1:02:29.200
<v Speaker 2>And I think it's one of those things that just

1:02:29.400 --> 1:02:32.680
<v Speaker 2>as evolution is working, as selection against our bivery works

1:02:32.720 --> 1:02:36.200
<v Speaker 2>on it. You just have instances where it's either you

1:02:36.280 --> 1:02:39.200
<v Speaker 2>just have some sort of byproduct where a mutation leads

1:02:39.200 --> 1:02:40.920
<v Speaker 2>to it and it just happens to be more bitter,

1:02:41.040 --> 1:02:43.440
<v Speaker 2>And I think it's sort of selection against. You know,

1:02:43.520 --> 1:02:46.800
<v Speaker 2>insects are really good at acclimating and evolving. That's is

1:02:46.800 --> 1:02:49.040
<v Speaker 2>that evolutionary arms, right, This is why we have so

1:02:49.080 --> 1:02:52.720
<v Speaker 2>many chemical pesticides within the plant community. It's just because

1:02:53.080 --> 1:02:55.800
<v Speaker 2>insects are really good at adapting because their generation times

1:02:55.800 --> 1:02:59.920
<v Speaker 2>are so low. So I think it's a complex molecule,

1:03:00.120 --> 1:03:01.600
<v Speaker 2>and I think it's one of those things that just

1:03:01.680 --> 1:03:04.520
<v Speaker 2>kind of gets refined depending on the selection pressures of

1:03:04.520 --> 1:03:07.680
<v Speaker 2>that given environment, and of course anything that's valuable to us,

1:03:08.160 --> 1:03:11.360
<v Speaker 2>and especially in terms of you know, things that are tasty,

1:03:11.520 --> 1:03:14.800
<v Speaker 2>we breed it to do way more than it normally

1:03:14.840 --> 1:03:16.480
<v Speaker 2>would in the wild. Which I have a really cool

1:03:16.520 --> 1:03:20.640
<v Speaker 2>episode that's involving THHD coming out soon, which has similar

1:03:20.800 --> 1:03:24.280
<v Speaker 2>conclusions in terms of our use versus natural background.

1:03:24.840 --> 1:03:27.840
<v Speaker 3>Interesting, Yeah, that sounds like a fun episode.

1:03:28.840 --> 1:03:31.479
<v Speaker 2>It is, and I'm really excited for it. But yeah,

1:03:31.520 --> 1:03:36.240
<v Speaker 2>so at lower const at lower concentrations, these methyls anthems,

1:03:36.280 --> 1:03:39.919
<v Speaker 2>as Aaron already pointed out, are really good pesticides and

1:03:40.080 --> 1:03:43.640
<v Speaker 2>they activate something within the insects which I actually wanted

1:03:43.680 --> 1:03:48.400
<v Speaker 2>to ask Aaron about. This is the identilate cyclase they

1:03:48.440 --> 1:03:51.720
<v Speaker 2>activate that they made that they put that out there

1:03:51.760 --> 1:03:53.160
<v Speaker 2>and we're just like, of course it does that, And

1:03:53.200 --> 1:03:54.280
<v Speaker 2>I was like, what.

1:03:54.760 --> 1:03:57.840
<v Speaker 3>Yeah, that's the getting into the biochemistry of things that

1:03:57.920 --> 1:04:01.240
<v Speaker 3>I'm not going to get into. But like denizene receptors.

1:04:01.520 --> 1:04:05.680
<v Speaker 3>Some of them increase cyclic amp, some of them decrease

1:04:05.720 --> 1:04:09.360
<v Speaker 3>cyclic amp, so then caffeine. So it's all basically the

1:04:09.400 --> 1:04:16.320
<v Speaker 3>same general compounds that it's going to effect in insects

1:04:16.440 --> 1:04:20.080
<v Speaker 3>versus humans and other mammals, if that makes sense, Like

1:04:20.160 --> 1:04:23.480
<v Speaker 3>on a biomolecular level, it's the same basic stuff.

1:04:25.040 --> 1:04:30.240
<v Speaker 2>Cool, So apparently it works that way, But again, plants

1:04:30.240 --> 1:04:32.520
<v Speaker 2>have many ways in which they can defend themselves, and

1:04:32.560 --> 1:04:35.840
<v Speaker 2>there's mechanical defenses which are like the thorns and spines

1:04:35.880 --> 1:04:38.040
<v Speaker 2>that you grab a rose, you pay for it royally,

1:04:38.600 --> 1:04:40.840
<v Speaker 2>But it's also just having tough tissues. And what's cool

1:04:40.960 --> 1:04:43.600
<v Speaker 2>is that in early development of leaves and stems and stuff,

1:04:43.600 --> 1:04:46.560
<v Speaker 2>caffeine production is super high. But as the leaves mature

1:04:46.640 --> 1:04:49.400
<v Speaker 2>and become more tough, they you know, kind of reinforce

1:04:49.440 --> 1:04:52.960
<v Speaker 2>their cell membranes, caffeine production actually goes down, which is

1:04:53.000 --> 1:04:55.800
<v Speaker 2>why actually younger tea leaves are preferred. They have a

1:04:55.880 --> 1:04:59.080
<v Speaker 2>higher because they're softer and more vulnerable. They need the

1:04:59.160 --> 1:05:02.120
<v Speaker 2>chemical defenses before they can beef up their structural defenses,

1:05:02.120 --> 1:05:05.480
<v Speaker 2>which if you think in terms of investment in defenses,

1:05:05.880 --> 1:05:09.760
<v Speaker 2>making lots of chemicals is expensive, whereas just using and

1:05:09.840 --> 1:05:13.520
<v Speaker 2>reinforcing that lasts a lot longer. Oh, which is really cool.

1:05:13.520 --> 1:05:15.800
<v Speaker 1>Oh cool, that's really amazing.

1:05:16.640 --> 1:05:17.280
<v Speaker 4>Wow.

1:05:17.440 --> 1:05:22.160
<v Speaker 2>Yeah. Okay, So caffeine is in the seedlings really early on,

1:05:22.240 --> 1:05:25.440
<v Speaker 2>because again it's like those mechanical defenses. The seeds are small,

1:05:25.560 --> 1:05:29.520
<v Speaker 2>they're really vulnerable to herbivora's smaller stuff, especially like slugs

1:05:29.520 --> 1:05:32.680
<v Speaker 2>and everything that wants to eat a small tender seedling.

1:05:32.960 --> 1:05:36.080
<v Speaker 2>So caffeine production for about the first eight weeks is

1:05:36.320 --> 1:05:40.080
<v Speaker 2>super super high, and then it eventually starts to decline,

1:05:40.120 --> 1:05:42.760
<v Speaker 2>just like we see in leaves throughout the germination process.

1:05:42.800 --> 1:05:45.400
<v Speaker 2>And so as long as the seeds are small and

1:05:45.480 --> 1:05:48.960
<v Speaker 2>have this uniform soft tissue, this accumulation of caffeine is

1:05:49.000 --> 1:05:51.720
<v Speaker 2>just going to continue to increase, which is pretty amazing.

1:05:52.840 --> 1:05:55.240
<v Speaker 2>But as soon as the seeds start to toughen up,

1:05:55.600 --> 1:05:57.600
<v Speaker 2>that's when you start to see that decline, which again

1:05:57.640 --> 1:05:59.720
<v Speaker 2>goes back to this idea that nothing is being done

1:05:59.800 --> 1:06:03.000
<v Speaker 2>in sort of a wasteful sense, and that a lot

1:06:03.040 --> 1:06:07.240
<v Speaker 2>of these productions of chemicals, any chemical compound within a plant,

1:06:07.320 --> 1:06:10.600
<v Speaker 2>is it can either be inducible or it's really during

1:06:10.600 --> 1:06:13.120
<v Speaker 2>a short period of time of development because they're not

1:06:13.160 --> 1:06:15.160
<v Speaker 2>doing this for us. They're not doing it because we

1:06:15.200 --> 1:06:18.120
<v Speaker 2>want them to. They're doing it to protect themselves. And

1:06:18.440 --> 1:06:21.840
<v Speaker 2>within plants like tea, there's also a shift you'll see

1:06:21.880 --> 1:06:24.120
<v Speaker 2>in sort of where the caffeine's being stored. So once

1:06:24.160 --> 1:06:26.320
<v Speaker 2>those tea leaves really start to toughen up, they start

1:06:26.320 --> 1:06:30.120
<v Speaker 2>really packing it into their vacuoles, which whenever an insect

1:06:30.160 --> 1:06:32.440
<v Speaker 2>bites into it, those burst and that gets into their

1:06:32.440 --> 1:06:34.280
<v Speaker 2>mouth and that's where you start to see again that

1:06:34.360 --> 1:06:37.160
<v Speaker 2>sort of protection effect where it's just like, oh God,

1:06:37.200 --> 1:06:39.440
<v Speaker 2>this is disgusting. I got to stop eating it. But

1:06:39.520 --> 1:06:42.360
<v Speaker 2>they also put it into their vascular bundles, which is

1:06:42.400 --> 1:06:44.640
<v Speaker 2>the vascular tissue throughout the plant, and that's one of

1:06:44.640 --> 1:06:48.320
<v Speaker 2>the main conduits by which pathoenogenic fungi will attack. And

1:06:48.360 --> 1:06:52.200
<v Speaker 2>any organic gardener knows that a lot of antimicrobial properties

1:06:52.200 --> 1:06:54.480
<v Speaker 2>are within coffee grounds as long as you haven't boiled them,

1:06:54.520 --> 1:06:58.040
<v Speaker 2>and so there's also a big component of keeping microbial

1:06:58.040 --> 1:07:00.920
<v Speaker 2>pathogens a way, so it's not just herbivy protecting against

1:07:00.920 --> 1:07:03.960
<v Speaker 2>fungal attacks as well. But that's cool because it's also

1:07:04.160 --> 1:07:07.200
<v Speaker 2>kind of funneling it to the areas of the plant

1:07:07.240 --> 1:07:08.560
<v Speaker 2>that are most vulnerable.

1:07:09.120 --> 1:07:10.360
<v Speaker 1>That's super cool.

1:07:10.680 --> 1:07:12.040
<v Speaker 3>Plants are so smart.

1:07:13.440 --> 1:07:14.280
<v Speaker 2>Yeah.

1:07:14.520 --> 1:07:19.960
<v Speaker 1>So if the caffeine molecules act on insects in similar

1:07:20.040 --> 1:07:23.360
<v Speaker 1>ways as they do on humans, why And I don't

1:07:23.360 --> 1:07:26.919
<v Speaker 1>know who I'm directing this question towards or whom I'm

1:07:26.920 --> 1:07:30.920
<v Speaker 1>directing this question towards, But why do humans become dependent

1:07:31.040 --> 1:07:35.600
<v Speaker 1>and want more caffeine and insects are like eh? Because

1:07:35.640 --> 1:07:38.000
<v Speaker 1>I mean, obviously we like the bitterness, and there is

1:07:38.240 --> 1:07:43.560
<v Speaker 1>obviously bitter taste, and it's evolutionarily wise, I'll say, just

1:07:43.600 --> 1:07:46.960
<v Speaker 1>for lack of vocabulary at this point in the day

1:07:47.960 --> 1:07:50.480
<v Speaker 1>to avoid the taste of bitter things because it tends

1:07:50.520 --> 1:07:55.000
<v Speaker 1>to be you know, poisonous or toxic. But why are

1:07:55.080 --> 1:07:59.080
<v Speaker 1>there insects or animals in general that like caffeine?

1:08:00.200 --> 1:08:05.000
<v Speaker 2>Hmmm, that's a really good question. And I so, for instance,

1:08:05.000 --> 1:08:07.360
<v Speaker 2>if this was alcohol, I would say, yeah, there's tons

1:08:07.400 --> 1:08:09.520
<v Speaker 2>of evidence that animals are seeking it out and having

1:08:09.520 --> 1:08:12.920
<v Speaker 2>similar issues with alcohol that even humans have for caffeine.

1:08:12.960 --> 1:08:15.600
<v Speaker 2>I don't know. I don't think so, although there is

1:08:15.640 --> 1:08:17.720
<v Speaker 2>this evidence of like you know that we talked about

1:08:17.760 --> 1:08:20.120
<v Speaker 2>the civets having to pass the beans and making the

1:08:20.120 --> 1:08:22.640
<v Speaker 2>best cup of coffee, So I would say potentially, but

1:08:22.680 --> 1:08:25.080
<v Speaker 2>that's a mammal of a larger body mass I would assume,

1:08:25.520 --> 1:08:29.240
<v Speaker 2>you know, for as like anxiety written as I can

1:08:29.280 --> 1:08:31.519
<v Speaker 2>be after like two or three cups of coffee, a

1:08:31.560 --> 1:08:34.000
<v Speaker 2>few bites on a leaf for an insect is probably

1:08:34.680 --> 1:08:36.240
<v Speaker 2>really rough for that body mass.

1:08:36.600 --> 1:08:39.400
<v Speaker 3>Yeah, yeah, And I don't I don't want to say

1:08:39.439 --> 1:08:41.800
<v Speaker 3>like that the effects of caffeine are the same in

1:08:41.840 --> 1:08:44.040
<v Speaker 3>an insect as they are in a human. I just mean,

1:08:44.120 --> 1:08:47.439
<v Speaker 3>like on a molecular level, right, the like changes are

1:08:47.479 --> 1:08:50.720
<v Speaker 3>probably going to be similar, but right, right, right, the

1:08:50.800 --> 1:08:55.000
<v Speaker 3>mechanism of effect, right, Yeah, But that's it's a really

1:08:55.040 --> 1:08:55.880
<v Speaker 3>interesting question.

1:08:56.640 --> 1:08:59.559
<v Speaker 2>Yeah, I would be really curious to look at even

1:08:59.680 --> 1:09:02.360
<v Speaker 2>just because you have to figure like those coffee seeds

1:09:02.400 --> 1:09:05.040
<v Speaker 2>have to go somewhere, right, and the dispersals usually and

1:09:05.160 --> 1:09:07.760
<v Speaker 2>especially if it's a red berry aided by some sort

1:09:07.800 --> 1:09:10.400
<v Speaker 2>of animal, And so I wonder if caffeine, which will

1:09:10.400 --> 1:09:12.760
<v Speaker 2>actually get to in a little bit here some other

1:09:12.800 --> 1:09:16.839
<v Speaker 2>ways that maybe caffeine could work for animals and plants together.

1:09:17.680 --> 1:09:20.800
<v Speaker 2>But first I want to talk to you about competition,

1:09:21.640 --> 1:09:24.959
<v Speaker 2>because everyone thinks about plants as sort of the static

1:09:25.920 --> 1:09:28.519
<v Speaker 2>not really interacting with the world kind of organisms, and

1:09:28.640 --> 1:09:32.120
<v Speaker 2>especially not harming each other or working against each other.

1:09:32.160 --> 1:09:34.400
<v Speaker 2>You know, the World Wide Web stuff came out Kumbaya,

1:09:34.560 --> 1:09:38.439
<v Speaker 2>everything's getting along well. Actually, plants aren't competing all the time.

1:09:38.479 --> 1:09:41.240
<v Speaker 2>That's the only reason we have tall plants at all

1:09:41.360 --> 1:09:43.599
<v Speaker 2>is because they can shade each other out. They take

1:09:43.680 --> 1:09:47.320
<v Speaker 2>up space where other roots could go. They're competing for nutrients, water,

1:09:47.439 --> 1:09:49.519
<v Speaker 2>all of that sort of stuff. And so it makes

1:09:49.520 --> 1:09:53.360
<v Speaker 2>sense that at some point anti competition mechanisms would evolve

1:09:53.400 --> 1:09:56.080
<v Speaker 2>in some species. And there is a lot of evidence

1:09:56.400 --> 1:10:00.320
<v Speaker 2>that caffeine can be evolved can be involved in anti

1:10:00.040 --> 1:10:07.800
<v Speaker 2>i competition interactions among especially young plants. What So, they

1:10:07.840 --> 1:10:12.000
<v Speaker 2>looked at putting coffee seeds into augur just to see

1:10:12.000 --> 1:10:15.120
<v Speaker 2>what was going on with relative caffeine levels as plants

1:10:15.160 --> 1:10:18.200
<v Speaker 2>germinate and grown. We already established that they will really

1:10:18.280 --> 1:10:20.800
<v Speaker 2>ramp up production while the seedling itself is growing. But

1:10:20.840 --> 1:10:22.920
<v Speaker 2>what they found out is that the seed coat will

1:10:22.960 --> 1:10:26.880
<v Speaker 2>actually leach a considerable amount of caffeine up to twenty

1:10:26.920 --> 1:10:29.960
<v Speaker 2>two percent of the caffeine within the coat itself into

1:10:30.000 --> 1:10:35.160
<v Speaker 2>its surrounding environment. And when they use different levels of caffeine,

1:10:35.240 --> 1:10:38.719
<v Speaker 2>especially that reflect background natural levels of what we're seeing

1:10:38.760 --> 1:10:41.679
<v Speaker 2>from the leeching of the seeds. It's actually been shown

1:10:41.720 --> 1:10:48.200
<v Speaker 2>to inhibit germination and growth of the surrounding vegetation. How Yeah,

1:10:48.479 --> 1:10:51.519
<v Speaker 2>so these seedlings are releasing a ton of caffeine into

1:10:51.520 --> 1:10:55.720
<v Speaker 2>the soil, which will inhibit the germination of potential competitors

1:10:55.800 --> 1:10:59.599
<v Speaker 2>that could overgrow them and steal light, water, and nutrients

1:10:59.640 --> 1:11:03.519
<v Speaker 2>from them. So caffeine is actually also an anti competition compound.

1:11:03.720 --> 1:11:08.360
<v Speaker 2>It's allelopathy using chemical warfare. I do not know the

1:11:08.400 --> 1:11:11.840
<v Speaker 2>mechanisms of it, but I'm assuming it has something to

1:11:11.840 --> 1:11:14.120
<v Speaker 2>do with the metabolism. Here's a plant that's producing it,

1:11:14.200 --> 1:11:17.639
<v Speaker 2>harming other plants that might not be or it could

1:11:17.680 --> 1:11:20.559
<v Speaker 2>even just be within its own self, you know, within

1:11:20.600 --> 1:11:22.759
<v Speaker 2>its tissues, it's fine. But if it's in the soil,

1:11:22.960 --> 1:11:25.680
<v Speaker 2>interacting with the root hairs, maybe even you know, the

1:11:25.720 --> 1:11:28.200
<v Speaker 2>fungi that they're partnering with. There's a lot of mechanisms

1:11:28.600 --> 1:11:31.479
<v Speaker 2>with which allelopathy can work, and it's one of those

1:11:31.800 --> 1:11:33.920
<v Speaker 2>areas of science that we're only really starting to get

1:11:33.920 --> 1:11:37.479
<v Speaker 2>our heads wrapped around. And it's it's it's difficult to study,

1:11:37.520 --> 1:11:40.040
<v Speaker 2>so there's a lot of open ended questions. But that's

1:11:40.280 --> 1:11:43.519
<v Speaker 2>just call for more attention, call for more work. Coffee

1:11:43.600 --> 1:11:45.280
<v Speaker 2>is really easy to germinate, so it's something you could

1:11:45.320 --> 1:11:47.479
<v Speaker 2>do in a greenhouse study pretty much anywhere in the world.

1:11:47.600 --> 1:11:56.040
<v Speaker 2>So hey, kids, So what's amazing is we have this

1:11:56.120 --> 1:11:59.599
<v Speaker 2>dual benefit here. We have an anti herbivery antipathogen really

1:11:59.640 --> 1:12:02.639
<v Speaker 2>protect plants as they grow, and then they're also involved

1:12:02.680 --> 1:12:07.560
<v Speaker 2>in anti competition, so keeping your space free of potential competitors.

1:12:07.920 --> 1:12:11.760
<v Speaker 2>But going back to the question about citrus, there is

1:12:11.880 --> 1:12:14.960
<v Speaker 2>also evidence that caffeine is highly involved for a lot

1:12:15.040 --> 1:12:18.080
<v Speaker 2>of the plant species that produce it in pollination. And

1:12:18.120 --> 1:12:22.960
<v Speaker 2>this is where things get really cool. Yeah, yeah, yeah,

1:12:23.040 --> 1:12:25.640
<v Speaker 2>So this is best studied in coffee and citrus. But

1:12:25.680 --> 1:12:28.120
<v Speaker 2>again with the amount of plant species that are known

1:12:28.160 --> 1:12:30.120
<v Speaker 2>to do it and probably are still yet to be

1:12:30.320 --> 1:12:33.200
<v Speaker 2>kind of described or discovered to be doing it, a

1:12:33.240 --> 1:12:37.280
<v Speaker 2>lot of these plants pump small amounts of caffeine into

1:12:37.280 --> 1:12:41.280
<v Speaker 2>their nectar, small amounts not nearly enough to be at

1:12:41.280 --> 1:12:45.479
<v Speaker 2>that level of sort of anti orbavery or preventative. But

1:12:46.040 --> 1:12:48.960
<v Speaker 2>when they looked at this, they started asking these questions,

1:12:49.000 --> 1:12:51.920
<v Speaker 2>what is this anti orbivery compound doing in nectar? You know,

1:12:51.960 --> 1:12:53.800
<v Speaker 2>this is supposed to be the one place where a

1:12:53.800 --> 1:12:56.400
<v Speaker 2>plant really wants an organism or at least an insect

1:12:56.439 --> 1:13:00.519
<v Speaker 2>to interact with it. So they studied this in and

1:13:00.520 --> 1:13:02.280
<v Speaker 2>again all of this is done in species that have

1:13:02.320 --> 1:13:05.360
<v Speaker 2>been domesticated have use to humans just because of the funding,

1:13:05.400 --> 1:13:07.719
<v Speaker 2>but it really has a lot of implications for what's

1:13:07.840 --> 1:13:13.479
<v Speaker 2>going on out in the wild. Nonetheless, caffeine concentrations in

1:13:13.560 --> 1:13:17.759
<v Speaker 2>nectar were found to not exceed the bees bitter taste threshold,

1:13:17.800 --> 1:13:19.679
<v Speaker 2>and I really want to know how they decided where

1:13:19.720 --> 1:13:20.200
<v Speaker 2>that was.

1:13:21.880 --> 1:13:24.160
<v Speaker 3>They just asked their like, can you taste it now?

1:13:24.200 --> 1:13:26.160
<v Speaker 3>And the bees are like this, yes, and they're like

1:13:26.200 --> 1:13:28.680
<v Speaker 3>can you taste it now? And I'm like this.

1:13:30.080 --> 1:13:36.080
<v Speaker 2>And then they're like boos, booze. But the fact that

1:13:36.120 --> 1:13:38.600
<v Speaker 2>the levels and the leaves and the levels in the

1:13:38.640 --> 1:13:42.960
<v Speaker 2>nectar seem to be highly regulated for uptick and production,

1:13:43.080 --> 1:13:46.000
<v Speaker 2>but keeping below a threshold and the nectar implies that

1:13:46.040 --> 1:13:49.480
<v Speaker 2>there is some sort of a selection for pharmacological activity

1:13:50.240 --> 1:13:53.120
<v Speaker 2>within the nectar that isn't supposed to function as a repellent.

1:13:53.640 --> 1:13:57.799
<v Speaker 2>And what they found is that when researchers presented bees

1:13:58.000 --> 1:14:02.360
<v Speaker 2>with naturalistic levels of caffeine in any sort of drink.

1:14:03.560 --> 1:14:06.240
<v Speaker 2>The bees were able to not only remember, locate, and

1:14:06.400 --> 1:14:11.560
<v Speaker 2>understand the floral sense much higher than in any situation

1:14:11.680 --> 1:14:13.920
<v Speaker 2>in which there was no caffeine in the nectar.

1:14:15.120 --> 1:14:20.040
<v Speaker 3>So it also increased their alertness and their productivity, and

1:14:20.160 --> 1:14:21.200
<v Speaker 3>their and their.

1:14:20.920 --> 1:14:23.840
<v Speaker 1>Focus and their guests desire to poop.

1:14:25.280 --> 1:14:28.479
<v Speaker 2>Yep, they're just squirting little bee poops everywhere as they go.

1:14:30.200 --> 1:14:32.519
<v Speaker 2>But the thought is that actually the plants have also

1:14:32.600 --> 1:14:35.080
<v Speaker 2>co opted a slight amount of caffeine in their nectar

1:14:35.120 --> 1:14:38.920
<v Speaker 2>to enhance the memories of reward within their pollinators, which

1:14:39.000 --> 1:14:43.560
<v Speaker 2>secures pollinator fidelity and improves the reproductive success of the

1:14:43.600 --> 1:14:44.400
<v Speaker 2>plant overall.

1:14:44.840 --> 1:14:47.600
<v Speaker 1>That is incredible. That is beautiful.

1:14:48.000 --> 1:14:53.400
<v Speaker 2>It's mind blowing. So you have defense, you have minimizing competition,

1:14:53.600 --> 1:14:55.960
<v Speaker 2>and you've got your sex taken care of. This is

1:14:56.200 --> 1:14:59.840
<v Speaker 2>hitting all three of the major instances of things that

1:15:00.040 --> 1:15:04.559
<v Speaker 2>actually influence plants in all steps of their life. Some

1:15:04.600 --> 1:15:07.559
<v Speaker 2>of the most basic things in life is surviving, not

1:15:07.640 --> 1:15:10.280
<v Speaker 2>getting sick, and being able to reproduce, and caffeine is

1:15:10.320 --> 1:15:12.680
<v Speaker 2>involved apparently in all of those in the species that

1:15:12.840 --> 1:15:14.760
<v Speaker 2>is producing it, that are producing it.

1:15:15.080 --> 1:15:20.840
<v Speaker 4>Wow, Wow, what a gorgeous story did you come across

1:15:20.920 --> 1:15:27.200
<v Speaker 4>anywhere about like when it was estimated that caffeine first evolved,

1:15:28.000 --> 1:15:31.400
<v Speaker 4>like when plants first started to produce caffeine.

1:15:32.120 --> 1:15:35.040
<v Speaker 2>So I did, but it seems like one of those

1:15:35.040 --> 1:15:39.080
<v Speaker 2>things that's like heavily debated because you do have gymnosperms

1:15:39.080 --> 1:15:44.000
<v Speaker 2>that produce like ephedra is from ephedrin is from ephedra,

1:15:44.080 --> 1:15:47.160
<v Speaker 2>which is a gymnosperm that's probably much older than most

1:15:47.160 --> 1:15:51.600
<v Speaker 2>of the flowering plant lineages, and estimates put most conservative

1:15:51.640 --> 1:15:54.320
<v Speaker 2>the evolution of flowering plants somewhere in their cretaceous so

1:15:54.360 --> 1:15:57.720
<v Speaker 2>when t Rex was rooming the landscape, and so, you know,

1:15:57.800 --> 1:16:00.200
<v Speaker 2>some of these lineages can be dated back to the

1:16:00.240 --> 1:16:03.920
<v Speaker 2>Miocene the Eocene, you know, so forty fifty million years ago,

1:16:03.960 --> 1:16:06.240
<v Speaker 2>but some of these lineages go back much farther. There's

1:16:06.240 --> 1:16:09.280
<v Speaker 2>fossil evidence for them, and the problem is is we

1:16:09.360 --> 1:16:11.320
<v Speaker 2>just don't know. It's you can't look at a fossil

1:16:11.360 --> 1:16:13.920
<v Speaker 2>and tell what kind of chemical constituents were being produced.

1:16:14.000 --> 1:16:16.280
<v Speaker 2>All we can say is this is affiliated with this order.

1:16:16.640 --> 1:16:18.559
<v Speaker 2>This order is known for producing a lot of it.

1:16:19.200 --> 1:16:20.120
<v Speaker 2>Potentially it was.

1:16:20.080 --> 1:16:23.519
<v Speaker 1>There, yeah, yeah, And are they all? Are all of

1:16:23.560 --> 1:16:30.120
<v Speaker 1>these plant species concentrated in the tropics and subtropics, so.

1:16:30.080 --> 1:16:32.280
<v Speaker 2>The major ones that we talked about today. Yes, and

1:16:32.320 --> 1:16:36.400
<v Speaker 2>there is a really interesting latitudinal gradient if for anyone

1:16:36.439 --> 1:16:40.320
<v Speaker 2>that's familiar with this, it's basically going from the poles

1:16:40.360 --> 1:16:44.840
<v Speaker 2>to the equator, there's usually a really strong gradient of

1:16:44.880 --> 1:16:48.880
<v Speaker 2>like spices, all of these antimicrobial, anti herbivy compounds. They

1:16:48.880 --> 1:16:51.240
<v Speaker 2>increase the closer you get to the equator. But so

1:16:51.320 --> 1:16:54.639
<v Speaker 2>does biodiversity. So all of the pressures and the climate

1:16:54.800 --> 1:16:59.360
<v Speaker 2>of like inducing microbial attacks, fungal attacks, those are all

1:16:59.400 --> 1:17:01.840
<v Speaker 2>way worse than the tropics. So the idea that you

1:17:01.880 --> 1:17:04.920
<v Speaker 2>would see a lot more plants potentially stumbling onto this

1:17:04.960 --> 1:17:08.080
<v Speaker 2>evolutionary process in the tropics, it just makes biological sense

1:17:08.080 --> 1:17:10.799
<v Speaker 2>in the long run, like the laws of thermodynamics probably

1:17:10.840 --> 1:17:13.519
<v Speaker 2>play in there just as much as as evolution does.

1:17:14.080 --> 1:17:17.839
<v Speaker 1>Oh yeah, I love these episodes.

1:17:17.960 --> 1:17:21.320
<v Speaker 3>I was just gonna say that I love these episodes

1:17:21.400 --> 1:17:22.320
<v Speaker 3>so much.

1:17:23.600 --> 1:17:26.400
<v Speaker 2>These are the horizon expanding episodes for me, because it's

1:17:26.400 --> 1:17:30.840
<v Speaker 2>like I am able to connect so many more dots afterwards.

1:17:31.240 --> 1:17:33.519
<v Speaker 1>So cool, that's so cool.

1:17:34.479 --> 1:17:37.920
<v Speaker 3>Wow, plants are really incredible. We don't give them enough credit.

1:17:38.040 --> 1:17:40.400
<v Speaker 2>I'm telling you, that's why I'm here.

1:17:41.560 --> 1:17:47.320
<v Speaker 3>Well, it's why we need to. Oh that was so fun.

1:17:47.360 --> 1:17:48.439
<v Speaker 3>Thank you so much.

1:17:48.640 --> 1:17:53.560
<v Speaker 1>I learned. Gosh, yeah, thank you so great. Yes, thank you.

1:17:53.600 --> 1:17:56.120
<v Speaker 2>I always walk away a more full person after this.

1:17:56.400 --> 1:18:01.000
<v Speaker 1>Thank you very much. Oh this was great. Now we

1:18:01.120 --> 1:18:03.479
<v Speaker 1>just have to it was brainstorm our next one.

1:18:04.400 --> 1:18:04.719
<v Speaker 4>Yeah.

1:18:04.760 --> 1:18:06.719
<v Speaker 1>Any requests anyone, send them our way?

1:18:07.040 --> 1:18:07.639
<v Speaker 2>Yeah? Please.

1:18:08.280 --> 1:18:09.880
<v Speaker 1>I guess do we do sources? Now?

1:18:09.880 --> 1:18:10.839
<v Speaker 3>You should do sources?

1:18:10.920 --> 1:18:15.599
<v Speaker 1>Yeah, okay, so let me pull mine up. I drew

1:18:15.800 --> 1:18:19.000
<v Speaker 1>heavily from a few different books that I'll mention. One

1:18:19.200 --> 1:18:22.000
<v Speaker 1>was called The World of Caffeine, The Science and Culture

1:18:22.040 --> 1:18:25.639
<v Speaker 1>of the World's most Popular Drug by Weinberg and Beeler,

1:18:26.120 --> 1:18:28.840
<v Speaker 1>and then I also read I also listened to a

1:18:28.880 --> 1:18:31.160
<v Speaker 1>book because it's only an audio book, which is the

1:18:31.160 --> 1:18:36.280
<v Speaker 1>first time I've encountered that called Caffeine, How Caffeine Created

1:18:36.280 --> 1:18:39.519
<v Speaker 1>the Modern World by Michael Pollin, and then finally by

1:18:39.680 --> 1:18:43.720
<v Speaker 1>Mayor and Hoe, The True History of Tea. And I

1:18:43.800 --> 1:18:47.880
<v Speaker 1>watched a documentary that is on YouTube called Black Coffee,

1:18:47.920 --> 1:18:50.640
<v Speaker 1>and it's a Canadian National Film Board documentary. It's like

1:18:50.680 --> 1:18:53.920
<v Speaker 1>a three parter. It's really interesting, but I will say

1:18:53.920 --> 1:18:57.040
<v Speaker 1>that the last section is like a bit too much

1:18:57.120 --> 1:18:59.320
<v Speaker 1>like a Starbucks episode for me to feel comfortable with.

1:18:59.439 --> 1:19:03.759
<v Speaker 2>But the first two great cool. So yeah. I pulled

1:19:03.760 --> 1:19:06.599
<v Speaker 2>from a handful of papers that I guess we can

1:19:06.640 --> 1:19:08.599
<v Speaker 2>link in the show notes or whatever you like to do.

1:19:08.680 --> 1:19:12.439
<v Speaker 2>So the first one was Caffeine and related methylsanthenes possible

1:19:12.560 --> 1:19:18.080
<v Speaker 2>natural occurring pesticides by Nathan nineteen eighty four, oh Nathanson,

1:19:18.200 --> 1:19:22.080
<v Speaker 2>nineteen eighty four. The second one was purine alkaloid formation

1:19:22.240 --> 1:19:26.840
<v Speaker 2>in buds and developing leaflets of Coffea Arabica expression of

1:19:26.880 --> 1:19:32.599
<v Speaker 2>an optimal defense strategy by frisknect at All nineteen eighty six.

1:19:33.520 --> 1:19:37.560
<v Speaker 2>Convergent evolution of caffeine implants by co option of exacted

1:19:37.640 --> 1:19:43.760
<v Speaker 2>ancestral enzymes by Hwenga at All twenty sixteen. And the

1:19:43.800 --> 1:19:49.360
<v Speaker 2>immune immunohistochemical localization of caffeine and young Camellia sinensis by

1:19:49.640 --> 1:19:53.160
<v Speaker 2>Breda at All twenty thirteen. And then finally, caffeine in

1:19:53.240 --> 1:19:56.800
<v Speaker 2>floral nectar enhances a pollinator's memory of reward by right

1:19:56.880 --> 1:19:58.120
<v Speaker 2>at All twenty thirteen.

1:19:59.040 --> 1:20:06.040
<v Speaker 3>Awesome, excellent. I had a number of articles. I don't

1:20:06.080 --> 1:20:10.559
<v Speaker 3>want to read all of their titles, so suffice to

1:20:10.600 --> 1:20:13.840
<v Speaker 3>say we will post them all on our website, this

1:20:14.000 --> 1:20:16.479
<v Speaker 3>podcast will kill You dot com, where you can find

1:20:16.520 --> 1:20:19.120
<v Speaker 3>our sources for this episode and every single one of

1:20:19.120 --> 1:20:23.280
<v Speaker 3>our episodes. There's some great ones, especially if you want

1:20:23.320 --> 1:20:26.400
<v Speaker 3>to read more about, for example, the effects on dementia,

1:20:27.000 --> 1:20:29.760
<v Speaker 3>whether or not it's a diuretic, the effects on your

1:20:29.800 --> 1:20:32.920
<v Speaker 3>cardiovascular health, et cetera, et cetera. I got papers for

1:20:33.000 --> 1:20:33.719
<v Speaker 3>all those.

1:20:34.280 --> 1:20:37.920
<v Speaker 1>And we'll also put all of these onto our bookshop

1:20:37.960 --> 1:20:41.920
<v Speaker 1>dot org affiliate page, as well as our Goodreads booklist,

1:20:42.240 --> 1:20:45.280
<v Speaker 1>so if you want to read some books or listen

1:20:45.320 --> 1:20:46.599
<v Speaker 1>to some books, check them out.

1:20:47.840 --> 1:20:48.120
<v Speaker 2>Well.

1:20:48.360 --> 1:20:51.000
<v Speaker 3>Thank you again, Matt so much for coming on. We

1:20:51.360 --> 1:20:54.479
<v Speaker 3>love having you on this podcast. It's so much fun

1:20:54.520 --> 1:20:56.160
<v Speaker 3>and we learned so much every episode.

1:20:56.680 --> 1:20:59.559
<v Speaker 2>Thank you both so much for having me. It's always

1:20:59.600 --> 1:21:01.280
<v Speaker 2>a black I miss you all so much and I

1:21:01.320 --> 1:21:02.880
<v Speaker 2>can't wait till we can do this in person again.

1:21:03.200 --> 1:21:05.880
<v Speaker 1>Oh my gosh, I know, I know, I was just

1:21:05.920 --> 1:21:07.960
<v Speaker 1>thinking that and I was like, I can't even say,

1:21:08.040 --> 1:21:09.519
<v Speaker 1>it's too sad, but I.

1:21:09.600 --> 1:21:11.479
<v Speaker 2>Know, sorry, I'm the downer.

1:21:13.400 --> 1:21:15.599
<v Speaker 1>Well, hey, you usually I'm the downer, so it works.

1:21:17.840 --> 1:21:20.200
<v Speaker 1>And then when we do meet, we will drink all

1:21:20.240 --> 1:21:24.400
<v Speaker 1>the quarantinies. Well, we'll just carry on and then have

1:21:24.439 --> 1:21:25.880
<v Speaker 1>some caffeine for the next morning.

1:21:25.960 --> 1:21:27.840
<v Speaker 2>As we say, quarantines and coffee.

1:21:27.520 --> 1:21:31.240
<v Speaker 3>Will be It's a bad combo by the way, but

1:21:32.800 --> 1:21:33.519
<v Speaker 3>separate topic.

1:21:33.840 --> 1:21:35.960
<v Speaker 1>You mean for locos, bad for you?

1:21:36.080 --> 1:21:36.280
<v Speaker 4>Yeah?

1:21:37.760 --> 1:21:39.880
<v Speaker 2>What? Oh my god.

1:21:42.320 --> 1:21:45.000
<v Speaker 1>Also, thank you to Bloodmobile for providing the music for

1:21:45.040 --> 1:21:46.800
<v Speaker 1>this episode and all of our episodes.

1:21:47.200 --> 1:21:49.600
<v Speaker 3>And thank you to you listeners. We hope that you

1:21:49.720 --> 1:21:53.040
<v Speaker 3>enjoyed this episode. Thanks so much for sticking around.

1:21:53.320 --> 1:21:56.719
<v Speaker 1>Yes, thank you, thank you, thanks for listening. Wait, Matt,

1:21:56.760 --> 1:21:58.599
<v Speaker 1>you should tell everyone where to get where to listen

1:21:58.680 --> 1:22:00.000
<v Speaker 1>to your stuff, and where to find stuff.

1:22:00.160 --> 1:22:02.800
<v Speaker 2>Yeah. In Defensive Plants is on all the major podcastchers.

1:22:03.280 --> 1:22:05.640
<v Speaker 2>Just google it so you know iTunes, Spotify, Stitcher, that

1:22:05.680 --> 1:22:08.120
<v Speaker 2>sort of stuff. In Defensiveplants dot com is the website

1:22:08.280 --> 1:22:11.160
<v Speaker 2>blog a lot of really cool updates. That's where you're

1:22:11.200 --> 1:22:13.720
<v Speaker 2>going to find them. Twitter, Instagram, please follow there. I've

1:22:13.720 --> 1:22:15.760
<v Speaker 2>got a lot of cool stuff coming out in the

1:22:15.800 --> 1:22:18.839
<v Speaker 2>next couple of months and big announcements, so please stay tuned.

1:22:18.880 --> 1:22:21.720
<v Speaker 2>If you enjoy these sorts of things, there's more to

1:22:21.760 --> 1:22:24.799
<v Speaker 2>be found. So yeah, go check it out and say.

1:22:24.720 --> 1:22:28.920
<v Speaker 1>Hi, Yeah I can I can attest that your the

1:22:28.920 --> 1:22:32.320
<v Speaker 1>in Defensive Plants Twitter or Instagram is incredible.

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<v Speaker 2>Thank you so I enjoy it.

1:22:34.960 --> 1:22:39.200
<v Speaker 1>I appreciate that great content. Okay, well, until next time,

1:22:39.520 --> 1:22:40.800
<v Speaker 1>wash your hands.

1:22:40.640 --> 1:23:01.679
<v Speaker 3>You filthy animals. Ou