WEBVTT - Organ Trail

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<v Speaker 1>When I was in second and third grade, I was

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<v Speaker 1>obsessed with mysteries Carmen San Diego, Encyclopedia Brown, Agatha Christie,

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<v Speaker 1>and especially Sherlock Holmes. On Thursday nights, I would stay

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<v Speaker 1>up late and snuggled under a blanket with my mom

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<v Speaker 1>watching mystery on PBS. But as much as I wanted

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<v Speaker 1>to solve all the neighborhood mysteries, I only ever cracked

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<v Speaker 1>two of them. First, the case of the nine year

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<v Speaker 1>old boxing champ. When a new kid moved to the

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<v Speaker 1>cul de Sac and claimed he was a world boxing

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<v Speaker 1>champ elementary school division, words spread fast across my neighborhood.

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<v Speaker 1>The kid was tough, He talked back to his mom,

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<v Speaker 1>he cursed, he spit, and he let it be known

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<v Speaker 1>he could beat up anyone who wanted to fight. My

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<v Speaker 1>neighbor dragged me along to see if it was true.

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<v Speaker 1>But a few questions about where he trained, what international

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<v Speaker 1>cities he traveled to, He had a hard time naming

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<v Speaker 1>any and also just pointing out the fact that he

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<v Speaker 1>had very soft hands quickly took the air out of

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<v Speaker 1>the myth. Second, the case of the Secret Admirer. Some

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<v Speaker 1>creep had signed all the Valentines to every girl in

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<v Speaker 1>our third grade class from your secret Admirer. My friends

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<v Speaker 1>Kristen and Sarah brought me the case. Our homeroom teacher,

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<v Speaker 1>Missus DeLong, had even received a secret Admirer card, which

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<v Speaker 1>was a total scandal. But after a little slew thing,

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<v Speaker 1>I realized that the night before, when I was out

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<v Speaker 1>playing basketball, my parents had called me in to sign Valentines,

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<v Speaker 1>and then after a while it got sick of calling

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<v Speaker 1>for me. My dad thought it would be funny to

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<v Speaker 1>sign all the cards anonymously, like I was some love

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<v Speaker 1>sick Casanova. It didn't take that long to solve the case,

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<v Speaker 1>but I didn't let on. I pretended it was unsolvable,

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<v Speaker 1>a mystery for the ages, and quickly shifted the conversation.

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<v Speaker 1>Sometimes solving a case is worse than not solving it.

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<v Speaker 1>Sometimes the answer feels wrong, even when it's right. All

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<v Speaker 1>that's to say, I think my work is often about

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<v Speaker 1>solving mysteries. I like patching the hole in the story.

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<v Speaker 1>I love hearing a curious fact or reading a line

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<v Speaker 1>that doesn't sound right, and then poking around to get

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<v Speaker 1>the full story. So in October of last year, as

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<v Speaker 1>I was starting to gather leads for this show. I

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<v Speaker 1>hopped on the phone with an investor to hear about

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<v Speaker 1>what they'd been pitched in the longevity space, and as

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<v Speaker 1>they walked me through new ideas for drugs and procedures,

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<v Speaker 1>suddenly I heard a cloud of phrases that made me

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<v Speaker 1>lean in.

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<v Speaker 2>We didn't invest because it makes us too uncomfortable. It's

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<v Speaker 2>pulled straight out of sci fi. They're brilliant, but their

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<v Speaker 2>reputations are controversial.

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<v Speaker 1>They want to remain anonymous, so I've had their tape

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<v Speaker 1>replaced with an actor, by which I mean my cousin. Anyway,

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<v Speaker 1>the investor tells me that in the.

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<v Speaker 2>Pitch there's a line item that stands out. It's for

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<v Speaker 2>buying property in South America.

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<v Speaker 1>So then they asked why is real estate part of

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<v Speaker 1>this pitch, and the answer it's.

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<v Speaker 2>Because they're going to buy property to catch monkeys they

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<v Speaker 2>can test on what.

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<v Speaker 1>My mind is spinning trying to understand what they're talking about.

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<v Speaker 1>And then I hear.

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<v Speaker 2>This The goal is to clone humans and use them

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<v Speaker 2>for human organ farms.

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<v Speaker 1>And that's the moment I knew the game is afoot.

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<v Speaker 1>From Kaleidoscope and iHeart podcasts, I'm Monga's heat there. This

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<v Speaker 1>is Skyline Drive How to Live Forever, Chapter one. Dear Leaders,

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<v Speaker 1>as the present.

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<v Speaker 3>Dish state, you.

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<v Speaker 4>Americans do not eat what grows for free, like amazing,

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<v Speaker 4>very tasty fruit lying on the end. In Russia, people

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<v Speaker 4>gather things from the treats. I think Americans want to pay, definitely,

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<v Speaker 4>this is amazing.

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<v Speaker 1>I'm walking with Mikyle Rubin over to this little patch

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<v Speaker 1>of grass on the Stanford campus, and he's right. We

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<v Speaker 1>spot orange trees everywhere, and despite my love of citrus,

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<v Speaker 1>it hadn't occurred to me to pick up any fruit

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<v Speaker 1>off the ground. In spite of his scolding slash teasing me,

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<v Speaker 1>I feel lucky to be here with Mikyle. He made

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<v Speaker 1>his name at a publication called Prey Act, breaking stories

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<v Speaker 1>about Russia's political corruption and the oligarchy.

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<v Speaker 5>There.

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<v Speaker 1>The guy is fearless.

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<v Speaker 4>We specialize on prohibited topics in Russia. So our goal

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<v Speaker 4>is to tell the stories that no one else would

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<v Speaker 4>ever tell, which is mostly everything about lighting me Puicha actually.

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<v Speaker 1>But Mikile is an exile here because us. In twenty

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<v Speaker 1>twenty one.

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<v Speaker 4>We got, let's say, a signal that we need to

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<v Speaker 4>leave the country, which was very direct searchers by the police,

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<v Speaker 4>questions by the police. Then we got this title of

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<v Speaker 4>undesirable organization, which means prison, so very pretty direct signal

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<v Speaker 4>that we need to leave the country. Since my exile

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<v Speaker 4>started four years now, five years ago now, we changed

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<v Speaker 4>places very often, countries places.

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<v Speaker 1>So I really do feel like I'm in a mystery

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<v Speaker 1>or maybe a paranoid conspiracy thriller. I'm chasing this rumor

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<v Speaker 1>of human cloning, human organ farms. I'm meeting with an

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<v Speaker 1>exile journalist under an orange tree at Stanford, and right

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<v Speaker 1>now we're talking about a strange bit of tape that

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<v Speaker 1>emerged on the internet last year. That's Chinese President Hi

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<v Speaker 1>Jinping walking with Vladimir Putin during a military parade in Beijing.

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<v Speaker 1>An essays stroll through the help of their translators, the

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<v Speaker 1>two seventy two year olds are saying that seventy used

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<v Speaker 1>to be considered ancient, but these days being seventy is

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<v Speaker 1>like being a child. Then Putin suggests that maybe people

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<v Speaker 1>will age backwards by replacing their organs and so essentially

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<v Speaker 1>becoming immortal. She chuckles and ads it could be in

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<v Speaker 1>this century humans might be able to live to one

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<v Speaker 1>hundred and fifty years old. That exchange went viral, because

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<v Speaker 1>of course it did. It's terrifying, But to Mikail.

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<v Speaker 4>It wasn't surprised for me at all, as an investigative

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<v Speaker 4>journalist who covers lead in the Putin for most part

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<v Speaker 4>of his career, that he is definitely obsessed. I am

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<v Speaker 4>using this word intentionally. He's obsessed with his health.

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<v Speaker 1>All knows a lot about that. Among other things. He

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<v Speaker 1>was the one who broke the story about Putin adding

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<v Speaker 1>a bath bomb of antler blood extract to his top,

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<v Speaker 1>a Siberian folk treatment for virility, which only amplified Putin's

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<v Speaker 1>myth internationally.

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<v Speaker 4>Like back at like fifteen years ago, they were published

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<v Speaker 4>his photos half naked you riding a horse and swimming.

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<v Speaker 4>It was important part of his image. What we understand

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<v Speaker 4>now is that he wants to live for a very

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<v Speaker 4>very long time, and we found some proofs for that.

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<v Speaker 1>Mckail and his team also broke a story about contracts

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<v Speaker 1>between the Russian President's office and hotels near his various

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<v Speaker 1>homes and who was traveling with Putin along with when.

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<v Speaker 4>So we find that every time Putin travels some way

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<v Speaker 4>out of Moscow, there is a bunch of doctors traveling

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<v Speaker 4>with him and who have to leave very close to

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<v Speaker 4>his residences. Usually it is from four up to seven

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<v Speaker 4>doctors traveling with him, but there were two times when

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<v Speaker 4>Putin was visited by twelve doctors simultaneously.

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<v Speaker 1>The reporters determined that Putin was likely treated for thyroid

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<v Speaker 1>cancer in secret, and that he'd had hernia surgery too.

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<v Speaker 1>Of course, this isn't the kind of thing the Kremlin confirms.

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<v Speaker 1>If Putin disappeared for a few days, Mikael says, they'll

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<v Speaker 1>release pre recorded tapes of meetings to make it seem

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<v Speaker 1>like he's on the job as normal. How do you

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<v Speaker 1>figure out someone like Putin's health.

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<v Speaker 4>It is a prohibited topic in Russia, totally prohibited. This

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<v Speaker 4>is a part of Putin's image. He's always healthy. They

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<v Speaker 4>never tell that he's ill. Never.

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<v Speaker 1>In late May of twenty twenty six, the Wall Street

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<v Speaker 1>Journal released a story clarifying that Putin had earmarked twenty

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<v Speaker 1>six billion dollars for a longevity initiative. Pudin's daughter, a

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<v Speaker 1>pediatric endocrinologist who advises her father on genetics, and a

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<v Speaker 1>physicist who led the USSR's nuclear research project were put

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<v Speaker 1>In charge, and along with delivering new gene therapies for

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<v Speaker 1>slowing cellular aging. The scientists have two key tasks, both

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<v Speaker 1>dealing with organ transplants. The first to figure out how

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<v Speaker 1>to three D print organs in a lab, the second

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<v Speaker 1>using mini pigs as living incubators to grow and harvest organs.

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<v Speaker 1>If everything goes to plan, Russia will basically have generated

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<v Speaker 1>a body farm where fields of hearts and lungs and

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<v Speaker 1>kidneys will either be printed on demand or plucked from

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<v Speaker 1>a pig host to be implanted into a human. According

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<v Speaker 1>to the journal, the hope is that between these two initiatives,

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<v Speaker 1>people will be able to switch out body parts indefinitely.

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<v Speaker 1>Putin has invested billions in the idea and is targeting

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<v Speaker 1>a deadline that isn't as far off as you think,

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<v Speaker 1>just four years, which happens to be before the country's

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<v Speaker 1>next presidential election. Of course, all of this is being

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<v Speaker 1>pitched as a state priority, a way to make Russians healthier.

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<v Speaker 1>Right now, the life expectancy for the average Russian is

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<v Speaker 1>seventy three, putting Russia at a dismal one hundred and

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<v Speaker 1>nineteen out of two hundred and nine countries studied and

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<v Speaker 1>for a new recruit to its military from the moment

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<v Speaker 1>training starts to death in battle, their life expectancy averages

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<v Speaker 1>only up to three weeks. But when this organ replacement

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<v Speaker 1>therapy is ready, which Russian will be first in line.

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<v Speaker 1>I'm sure you can guess.

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<v Speaker 4>What I'm trying to say is that definitely this conversation

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<v Speaker 4>with presidentcy wasn't something newte and unfortunately for Russia that

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<v Speaker 4>his plan is also too for a very very long time.

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<v Speaker 1>Chapter two, Library Science. I can't stop thinking about this

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<v Speaker 1>dystopic vision for the future where if you have a

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<v Speaker 1>good mechanic and a warehouse full of parts, you can

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<v Speaker 1>keep a body running endlessly. I mean, I get the

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<v Speaker 1>idea you might need a pacemaker or to replace a

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<v Speaker 1>bum heart, but to just keep replacing parts forever. And

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<v Speaker 1>it makes me wonder about the urban myths I heard

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<v Speaker 1>in middle and high school of people going to a party,

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<v Speaker 1>getting drugged and then waking up in bathtubs of ice

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<v Speaker 1>without a kidney, which is why Lizzie and I ended

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<v Speaker 1>up in a local public library on a chilly January day,

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<v Speaker 1>sitting with a white hat hacker named Searchlight.

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<v Speaker 6>Going on to Darknet used to be a lot easier

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<v Speaker 6>because you could just go to a website and be like, look,

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<v Speaker 6>this is who's advertising organs.

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<v Speaker 1>Just so you know, that's not Searchlight's actual voice. Searchlight

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<v Speaker 1>works as an elite cybersecurity consultant and studies at one

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<v Speaker 1>of the country's most prestigious universities, and they only agreed

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<v Speaker 1>to talk to me if we kept their voice and

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<v Speaker 1>identity out of the show. It's near closing time, and

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<v Speaker 1>while it's not exactly busy, I'm nervous about who might

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<v Speaker 1>catch wind of what we're doing. The Searchlight tells us

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<v Speaker 1>that the library is a convenient way to access the

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<v Speaker 1>web without using your own IP address. They boot up

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<v Speaker 1>the computer, clear it of the existing searches and credentials.

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<v Speaker 6>If you ever want to take a photo of like this,

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<v Speaker 6>just don't take a photo of me.

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<v Speaker 1>They reassure us we won't actually be doing anything illegal,

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<v Speaker 1>which is a welcome reminder. A Searchlight begins typing, I'm

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<v Speaker 1>giddy to tour the dark web. I'm still thinking about

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<v Speaker 1>Silk Road, the so called black market Amazon where organ

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<v Speaker 1>trafficking was rumored to take place, but Searchlight says that

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<v Speaker 1>that part of the net is filled with government agents

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<v Speaker 1>running honeypot schemes on unsuspecting nubes and anyway, it's not

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<v Speaker 1>where the action is these days. So we're going regular

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<v Speaker 1>old surface web and searchlight starts by demonstrating how embarrassingly

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<v Speaker 1>easy it is to find longevity drugs here on the internet.

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<v Speaker 1>We all use how.

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<v Speaker 3>Long to take? And did it seem surprising?

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<v Speaker 1>How long a tike?

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<v Speaker 6>It took? Under a minute, which is wow, this is

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<v Speaker 6>so easy that why would you ever go through the

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<v Speaker 6>effort of going through the dark web for any of

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<v Speaker 6>these things?

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<v Speaker 1>By current estimates, the shadow markets are a six trillion

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<v Speaker 1>dollars a year economy. That includes money launcher and other

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<v Speaker 1>illicit activity too, but it also includes what we're looking

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<v Speaker 1>at right now, purchasing cancer drugs and anti virals for

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<v Speaker 1>HIV and anabolic androgenic steroids.

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<v Speaker 6>I'm assuming there's a lot of business incentives for why

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<v Speaker 6>this is happening, and a lot of incentive for illicit

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<v Speaker 6>pharmacies in other countries to be targeting the US market.

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<v Speaker 1>I angle my body boxing out any nosy neighbors from

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<v Speaker 1>being able to see the screen. I can't believe how

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<v Speaker 1>brazen this marketplace is. And while we're not talking about

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<v Speaker 1>purchasing organs. These are serious pharmaceuticals, things with real side effects,

0:15:37.600 --> 0:15:41.240
<v Speaker 1>which are being recommended on dodgy sites as off label

0:15:41.320 --> 0:15:45.680
<v Speaker 1>longevity meds search sites. Starts pecking at the keys again

0:15:45.960 --> 0:15:49.560
<v Speaker 1>and we're transported to the world of longevity chatboards, the

0:15:49.600 --> 0:15:53.560
<v Speaker 1>so called community helping a new class of initiates navigate

0:15:53.560 --> 0:15:58.000
<v Speaker 1>their hunt for drugs. The boards point new longevionauts to

0:15:58.040 --> 0:16:01.520
<v Speaker 1>which sites are most reliable, which services to use to

0:16:01.640 --> 0:16:05.200
<v Speaker 1>drop ship the drugs, which banks are better for discrete

0:16:05.200 --> 0:16:06.560
<v Speaker 1>international transfers.

0:16:06.960 --> 0:16:11.200
<v Speaker 6>Yeah, this is super detailed. This person decided to say

0:16:12.040 --> 0:16:15.880
<v Speaker 6>which regional facility their package arrived that and also when

0:16:16.160 --> 0:16:19.000
<v Speaker 6>they paid for it, and also when it arrived to them,

0:16:19.280 --> 0:16:21.840
<v Speaker 6>which is extremely detailed amount of information to put on

0:16:21.880 --> 0:16:24.560
<v Speaker 6>the public Internet about your crimes. Whether this is a

0:16:24.640 --> 0:16:27.720
<v Speaker 6>real name or not doesn't really matter. Essentially, if these

0:16:27.720 --> 0:16:31.280
<v Speaker 6>people are not having some dark web conversation or secret telegrams,

0:16:30.880 --> 0:16:32.400
<v Speaker 6>it's just on the Internet.

0:16:33.800 --> 0:16:36.560
<v Speaker 1>One post we look at about how to order rapamycin

0:16:37.000 --> 0:16:41.280
<v Speaker 1>has over fifty thousand views and hundreds of comments. Rapamycin

0:16:41.480 --> 0:16:45.920
<v Speaker 1>is an immunosuppressant, especially helpful in preventing rejection after say

0:16:46.320 --> 0:16:49.720
<v Speaker 1>a kidney transplant. While the drug has been much hyped

0:16:49.720 --> 0:16:53.480
<v Speaker 1>in longevity circles, it has plenty of documented side effects,

0:16:53.920 --> 0:16:58.720
<v Speaker 1>including mouth ulcers, wound healing issues, and disabling your immune system.

0:17:00.040 --> 0:17:03.680
<v Speaker 1>Anti aging potential for humans, if any is still unclear,

0:17:09.440 --> 0:17:12.479
<v Speaker 1>but at Searchlight points out, we don't really know anything

0:17:12.520 --> 0:17:15.000
<v Speaker 1>about who has set up this forum and what their

0:17:15.040 --> 0:17:15.760
<v Speaker 1>motives could be.

0:17:16.480 --> 0:17:19.359
<v Speaker 6>Who is this person? No idea. If this person's a

0:17:19.359 --> 0:17:21.600
<v Speaker 6>broker or supplier, then there's an incentive for them to

0:17:21.680 --> 0:17:24.200
<v Speaker 6>lie right and tell the people that it's safe when

0:17:24.240 --> 0:17:31.320
<v Speaker 6>it's not, and that's predatory.

0:17:31.760 --> 0:17:33.760
<v Speaker 1>A long time ago, a writer friend of mine told

0:17:33.760 --> 0:17:35.800
<v Speaker 1>me the story about getting in a minivan with a

0:17:35.840 --> 0:17:39.679
<v Speaker 1>formulae one driver on some blocked off roads in New Jersey,

0:17:40.280 --> 0:17:45.160
<v Speaker 1>a new supposed test track. The driver guns it, hurling

0:17:45.200 --> 0:17:48.080
<v Speaker 1>the minivan around corners, and as the writer sweats and

0:17:48.160 --> 0:17:52.360
<v Speaker 1>white knuckles the grab handles, the driver looks over and smirks,

0:17:54.119 --> 0:17:57.600
<v Speaker 1>showing just how much control over this soccer mom vehicle

0:17:57.760 --> 0:18:02.439
<v Speaker 1>he has. I'm reminded of that scene. A surflight whips

0:18:02.480 --> 0:18:05.480
<v Speaker 1>the browser across the web. Click, click, click, A few

0:18:05.560 --> 0:18:09.160
<v Speaker 1>keystrokes and something we're looking at discount injectables that stimulate

0:18:09.240 --> 0:18:12.800
<v Speaker 1>bone marrow to make more red blood cells. A few

0:18:12.840 --> 0:18:15.119
<v Speaker 1>more and we're racing to a site that claims to

0:18:15.160 --> 0:18:19.720
<v Speaker 1>be quote the best Indian pharmaceutical supplier in the Philippines

0:18:20.160 --> 0:18:25.080
<v Speaker 1>that also ships to the US. This is f one handling,

0:18:25.160 --> 0:18:28.240
<v Speaker 1>not some web tourists working the wheel, and we skid

0:18:28.280 --> 0:18:31.320
<v Speaker 1>past disclosures or lack of them on so many sites.

0:18:35.840 --> 0:18:38.760
<v Speaker 1>When we tap the brakes, Searflight points out the market

0:18:38.800 --> 0:18:42.199
<v Speaker 1>here is wider than just longebonouts. It's also filled with

0:18:42.200 --> 0:18:45.560
<v Speaker 1>people with serious health conditions who've been abandoned by a

0:18:45.640 --> 0:18:49.840
<v Speaker 1>broken healthcare system. People left scouring the internet for cheaper

0:18:49.920 --> 0:18:53.800
<v Speaker 1>versions of the drugs they can't afford, for.

0:18:53.800 --> 0:18:55.960
<v Speaker 6>People who actually need these medications and are going on

0:18:56.000 --> 0:18:59.080
<v Speaker 6>these websites because they just can't afford them, because they're

0:18:59.080 --> 0:19:01.919
<v Speaker 6>like five thousand dollars injection in the US. They're like,

0:19:02.119 --> 0:19:05.120
<v Speaker 6>they're like really expensive. You can't blame them for going

0:19:05.119 --> 0:19:05.920
<v Speaker 6>on these websites.

0:19:06.080 --> 0:19:09.040
<v Speaker 1>And Searchlight tells me these chemicals are not made for

0:19:09.119 --> 0:19:11.800
<v Speaker 1>people to take, They're for research only.

0:19:12.119 --> 0:19:13.920
<v Speaker 6>It's still unsafe and it should be shut down.

0:19:20.560 --> 0:19:22.960
<v Speaker 1>I'm thinking of my dad, how at the end of

0:19:22.960 --> 0:19:25.680
<v Speaker 1>his life when he knew things weren't going right. He'd

0:19:25.760 --> 0:19:28.800
<v Speaker 1>ordered these ira Vedic tinctures that he thought could maybe

0:19:28.840 --> 0:19:32.919
<v Speaker 1>heal him. It was this act of desperation, and I

0:19:32.960 --> 0:19:36.520
<v Speaker 1>had no idea what he'd bought, or from where, or

0:19:36.520 --> 0:19:42.120
<v Speaker 1>how he'd even research these supposed cures. But as much

0:19:42.160 --> 0:19:45.240
<v Speaker 1>as I didn't want it to be true, I knew

0:19:45.240 --> 0:19:46.160
<v Speaker 1>they weren't going to work.

0:19:48.680 --> 0:19:50.800
<v Speaker 6>I think what it really says about the longevity situation

0:19:50.960 --> 0:19:54.320
<v Speaker 6>is like this is being discussed openly. There is the

0:19:54.359 --> 0:19:57.840
<v Speaker 6>opportunity to know, hey, these drugs are dangerous, Like there's

0:19:57.920 --> 0:19:59.919
<v Speaker 6>guidance that can be and hasn't been put up by

0:20:00.200 --> 0:20:03.280
<v Speaker 6>FDA saying these longevity drugs are off label and are

0:20:03.320 --> 0:20:04.200
<v Speaker 6>dangerous to be using.

0:20:20.760 --> 0:20:23.960
<v Speaker 1>My mind is reeling. For the same price as a

0:20:24.000 --> 0:20:27.119
<v Speaker 1>dinner out, I can buy research grade drugs that cure

0:20:27.240 --> 0:20:32.399
<v Speaker 1>major diseases on essentially an open market. It's barely harder

0:20:32.440 --> 0:20:35.919
<v Speaker 1>than ordering sneakers off of eBay. But what about the

0:20:35.920 --> 0:20:38.879
<v Speaker 1>people who aren't desperate? What about the prudence of the

0:20:38.880 --> 0:20:42.040
<v Speaker 1>world who talk of switching out a bad heart or kidney,

0:20:42.320 --> 0:20:45.040
<v Speaker 1>treating the human body like a Lego kit where you

0:20:45.040 --> 0:20:48.320
<v Speaker 1>can just snap in new parts, or the whispers. I

0:20:48.440 --> 0:20:53.159
<v Speaker 1>keep hearing of ultra elite longevity mansions, residences where New

0:20:53.280 --> 0:20:56.800
<v Speaker 1>Zealand oil airs and their friends. The actual phrase one

0:20:56.840 --> 0:21:01.000
<v Speaker 1>source used gream up longevity experiments they can fund without

0:21:01.000 --> 0:21:04.359
<v Speaker 1>worry of ethics. So I go back to my original

0:21:04.480 --> 0:21:08.000
<v Speaker 1>question and ask Searchlight, are people buying new livers and

0:21:08.080 --> 0:21:09.400
<v Speaker 1>spare kidneys online?

0:21:10.280 --> 0:21:12.639
<v Speaker 6>Well, there's a lot of conversation about replacing kidneys and

0:21:12.680 --> 0:21:17.200
<v Speaker 6>things like that in the longevity community, but actually acting

0:21:17.240 --> 0:21:20.040
<v Speaker 6>on that is extremely fringe. And not only do I

0:21:20.080 --> 0:21:22.879
<v Speaker 6>not know anyone who's done that, I've never heard of

0:21:22.960 --> 0:21:25.000
<v Speaker 6>anybody who's heard of anybody who's done that.

0:21:26.640 --> 0:21:30.280
<v Speaker 1>For a minute, I feel relief, like an anxious parent

0:21:30.480 --> 0:21:33.680
<v Speaker 1>looking out onto an ocean and not seeing any fins

0:21:34.760 --> 0:21:39.800
<v Speaker 1>taking that is proof that the water is safe. Searchlight

0:21:39.880 --> 0:21:42.359
<v Speaker 1>says that if we want to go hunting for organ sales,

0:21:42.760 --> 0:21:45.879
<v Speaker 1>they could reboot the system and find a burner phone

0:21:45.880 --> 0:21:49.080
<v Speaker 1>for us to use, but the various security measures would

0:21:49.119 --> 0:21:52.120
<v Speaker 1>take more time than we have. The library is about

0:21:52.160 --> 0:21:56.320
<v Speaker 1>to close. Besides, they explained to me, organ trafficking isn't

0:21:56.400 --> 0:22:01.159
<v Speaker 1>just illegal, it also requires an incredible amount of coordination.

0:22:01.680 --> 0:22:06.199
<v Speaker 6>For extreme cases. Let's do an organ transplant illegally. It

0:22:06.280 --> 0:22:10.320
<v Speaker 6>requires a donor who's forced into donating organs, be trafficked

0:22:10.359 --> 0:22:12.960
<v Speaker 6>to a safe house and then have organs removed, and

0:22:13.000 --> 0:22:15.200
<v Speaker 6>then have a surgeon and a surgical feed are nearby

0:22:15.840 --> 0:22:18.760
<v Speaker 6>implant them into the recipient, and all of that has

0:22:18.800 --> 0:22:20.040
<v Speaker 6>to be coordinated by a broker.

0:22:22.040 --> 0:22:25.120
<v Speaker 1>A searchlight walks me through this. I'm realizing how hard

0:22:25.160 --> 0:22:27.760
<v Speaker 1>the recovery is, how easy it is for the body

0:22:27.800 --> 0:22:31.359
<v Speaker 1>to reject a foreign organ. The medicines you need to

0:22:31.400 --> 0:22:36.159
<v Speaker 1>override it. Even in the best circumstances. It is far

0:22:36.200 --> 0:22:36.880
<v Speaker 1>from smooth.

0:22:37.600 --> 0:22:40.240
<v Speaker 6>People who are primarily trying to get transplants on. Here

0:22:40.240 --> 0:22:43.600
<v Speaker 6>are people who actually need them but are just going

0:22:43.600 --> 0:22:47.520
<v Speaker 6>about it in extremely unethical ways that they just don't

0:22:47.520 --> 0:22:49.400
<v Speaker 6>care about the people who they're trying to get things

0:22:49.400 --> 0:22:51.280
<v Speaker 6>transplanted from.

0:22:51.480 --> 0:22:53.960
<v Speaker 1>And it feels like there's desperation on both sides, from

0:22:54.000 --> 0:22:56.760
<v Speaker 1>the person in dire need of a failing organ, but

0:22:57.000 --> 0:22:59.959
<v Speaker 1>also from the person for whom their own internal organs

0:23:00.440 --> 0:23:04.040
<v Speaker 1>maybe the most valuable things they have in or on.

0:23:04.240 --> 0:23:07.320
<v Speaker 1>In twenty twenty three, when inflation had gotten so bad

0:23:07.440 --> 0:23:11.840
<v Speaker 1>that poverty was rampant, people were posting on telegram offering

0:23:11.880 --> 0:23:16.080
<v Speaker 1>their livers, their bone marrow. According to Business Insider, someone

0:23:16.160 --> 0:23:20.520
<v Speaker 1>even posted an offer to sell their testicles quote twenty

0:23:20.520 --> 0:23:31.040
<v Speaker 1>five years old. Oh positive, I know searchlight can illuminate

0:23:31.080 --> 0:23:34.679
<v Speaker 1>the darkest corridors of the Internet, places I'd never be

0:23:34.720 --> 0:23:37.920
<v Speaker 1>able to find. Were all those rumors I'd heard from

0:23:38.000 --> 0:23:41.920
<v Speaker 1>vcs about organ replacement just another kind of urban myth.

0:23:42.880 --> 0:23:46.359
<v Speaker 1>Had we hit a dead end? I can't believe it.

0:23:47.280 --> 0:23:48.200
<v Speaker 1>There has to be.

0:23:48.160 --> 0:24:12.400
<v Speaker 5>A way Chapter three, Cracking the Faberge Egg.

0:24:15.200 --> 0:24:17.720
<v Speaker 1>In any detective story, there are moments when the trail

0:24:17.800 --> 0:24:21.440
<v Speaker 1>goes cold, when the pieces don't seem to fit, and

0:24:21.840 --> 0:24:25.040
<v Speaker 1>there are always options. You can play a violin and

0:24:25.480 --> 0:24:29.000
<v Speaker 1>hope for an inspired connection, or you can keep working

0:24:29.080 --> 0:24:32.840
<v Speaker 1>the neighborhood, tracing acquaintances, looking for one name to daisy

0:24:32.920 --> 0:24:36.320
<v Speaker 1>chain into the next. And in a community this small,

0:24:37.000 --> 0:24:39.840
<v Speaker 1>there's a sense that the young scientists with the boldest,

0:24:39.960 --> 0:24:43.879
<v Speaker 1>wildest ideas have all met each other, which is how

0:24:44.040 --> 0:24:47.080
<v Speaker 1>three days into my trip to San Francisco, I find

0:24:47.080 --> 0:24:48.680
<v Speaker 1>myself talking to Nicoa Poe.

0:24:49.600 --> 0:24:52.640
<v Speaker 7>The people I valued the most actually weren't encouraging at all.

0:24:52.720 --> 0:24:56.400
<v Speaker 7>They were just like, that's stupid entire thing, scrap.

0:24:58.400 --> 0:25:01.880
<v Speaker 1>That's what helped me, oh a lot of things. A vegan,

0:25:02.119 --> 0:25:06.200
<v Speaker 1>a former research assistant at Stanford an Army, National Guard Reserve,

0:25:06.640 --> 0:25:09.720
<v Speaker 1>and a startup founder running his trials at the Buck Institute,

0:25:10.000 --> 0:25:14.080
<v Speaker 1>a prestigious research institute devoted to longevity, where he's worked

0:25:14.080 --> 0:25:18.480
<v Speaker 1>on a way to replace his brain. But as we

0:25:18.600 --> 0:25:22.840
<v Speaker 1>sit in his office in Marin overlooking sweeping hills thick

0:25:22.880 --> 0:25:25.200
<v Speaker 1>with fog, he tells me he doesn't want to replace

0:25:25.200 --> 0:25:29.480
<v Speaker 1>his organs by transplant putin style. Instead, he's taking his

0:25:29.520 --> 0:25:34.719
<v Speaker 1>inspiration from an old philosophical thought experiment. The Ship of Theseus.

0:25:35.600 --> 0:25:39.320
<v Speaker 7>Theseus was this Greek explorer, right, and he goes on

0:25:39.359 --> 0:25:42.159
<v Speaker 7>a journey and the mast of his ship break, so

0:25:42.200 --> 0:25:46.399
<v Speaker 7>they replaced the mast. The board's break, so they replace

0:25:46.480 --> 0:25:48.520
<v Speaker 7>the boards, and by the end of the journey they've

0:25:48.560 --> 0:25:51.399
<v Speaker 7>replaced every single part of the ship with a new piece.

0:25:52.119 --> 0:25:56.520
<v Speaker 7>But everybody still calls it Theseus's ship and the like.

0:25:56.720 --> 0:26:00.879
<v Speaker 7>The philosophical question is if you completely play something piece

0:26:00.880 --> 0:26:02.879
<v Speaker 7>by piece, is it still what it started to be?

0:26:03.760 --> 0:26:06.000
<v Speaker 1>Nikoa has a theory about how you can replace your

0:26:06.119 --> 0:26:10.040
<v Speaker 1>entire brain piece by piece and still retain your identity.

0:26:10.560 --> 0:26:12.440
<v Speaker 1>And I want to know how he came to that belief.

0:26:16.359 --> 0:26:19.360
<v Speaker 1>Nikoa grew up in Hawaii with the health conscious hippie mom.

0:26:20.000 --> 0:26:23.760
<v Speaker 1>In college, he identifies two event horizons, and since he's

0:26:23.840 --> 0:26:27.320
<v Speaker 1>quote not good at ai, he decides to lean into

0:26:27.359 --> 0:26:31.639
<v Speaker 1>the other one, longevity. But even after studying biochemistry and

0:26:31.680 --> 0:26:34.600
<v Speaker 1>molecular biology and moving to the West Coast to work

0:26:34.640 --> 0:26:37.480
<v Speaker 1>in a Stanford lab, he wasn't satisfied.

0:26:38.080 --> 0:26:42.320
<v Speaker 7>So one of my lab mates goes, well, you won't

0:26:42.320 --> 0:26:45.320
<v Speaker 7>stop talking about immortality. Here's a house full of people

0:26:45.320 --> 0:26:54.439
<v Speaker 7>that just do That's amaze. So then I applied and

0:26:54.480 --> 0:26:57.440
<v Speaker 7>they gave me a very serious interview and they're like, yes, well,

0:26:57.480 --> 0:26:59.960
<v Speaker 7>we'll see if you're good enough for the next cohort.

0:27:00.080 --> 0:27:03.679
<v Speaker 7>I was like sweating, this is extremely serious. I'm going

0:27:03.760 --> 0:27:05.800
<v Speaker 7>to be living with a whole bunch of biotech legends.

0:27:05.840 --> 0:27:07.760
<v Speaker 7>And then I showed up and it was just like, oh,

0:27:07.760 --> 0:27:08.320
<v Speaker 7>what's up, bro.

0:27:13.640 --> 0:27:16.359
<v Speaker 1>But at Vida's house, whose stated mission is to create

0:27:16.359 --> 0:27:20.359
<v Speaker 1>community and quote incubate the most promising moonshots at the

0:27:20.359 --> 0:27:24.320
<v Speaker 1>intersections of biology and tech, was just what Nikoa needed.

0:27:25.000 --> 0:27:26.920
<v Speaker 1>I was out of Vida's house the day before and

0:27:27.280 --> 0:27:30.120
<v Speaker 1>had been charmed by the college off campus house feel

0:27:30.160 --> 0:27:30.320
<v Speaker 1>of it.

0:27:31.000 --> 0:27:33.119
<v Speaker 7>Our fridge had a whole bunch of different peptides in

0:27:33.200 --> 0:27:35.040
<v Speaker 7>it on the side, and I was having space to

0:27:35.600 --> 0:27:37.840
<v Speaker 7>store my hot sauce because there was like too many

0:27:38.160 --> 0:27:44.159
<v Speaker 7>vials of Reddit, trude eyed and other tiny little peptide fragments.

0:27:44.240 --> 0:27:45.080
<v Speaker 7>So that was fun.

0:27:46.480 --> 0:27:49.080
<v Speaker 1>And he finds inspiration all around him that make some

0:27:49.200 --> 0:27:52.320
<v Speaker 1>investors and fame researchers who drop by to give talks,

0:27:52.960 --> 0:27:54.840
<v Speaker 1>and the like minded residents who lived there.

0:27:55.720 --> 0:27:58.679
<v Speaker 7>Just having conversations and sharing my ideas with people and

0:27:58.720 --> 0:28:02.520
<v Speaker 7>coming like, look, I have this precious faberget egg of

0:28:02.560 --> 0:28:05.480
<v Speaker 7>an idea and I'm so proud of it. And then

0:28:05.520 --> 0:28:08.360
<v Speaker 7>they smash it and they're like, ninety percent of this

0:28:08.400 --> 0:28:10.240
<v Speaker 7>is garbage, and I go, okay, well I'll take this

0:28:10.320 --> 0:28:12.600
<v Speaker 7>ten percent. Look I have another wife.

0:28:13.040 --> 0:28:14.240
<v Speaker 1>Boom, Okay, well now I.

0:28:14.200 --> 0:28:17.080
<v Speaker 7>Have twenty percent of a good idea and just refeeding

0:28:17.119 --> 0:28:18.479
<v Speaker 7>that process.

0:28:18.720 --> 0:28:22.080
<v Speaker 1>And that's on a CoA started Sundial Therapeutics, an early

0:28:22.080 --> 0:28:26.400
<v Speaker 1>stage company focused on cellular brain replacement, whereas he likes

0:28:26.440 --> 0:28:27.000
<v Speaker 1>to call it.

0:28:27.359 --> 0:28:30.080
<v Speaker 7>The brain of theseus. Basically, what we do is we

0:28:30.119 --> 0:28:33.280
<v Speaker 7>look for stem cells that can cross the blood brain

0:28:33.359 --> 0:28:35.760
<v Speaker 7>barrier and home to sights of damage and injury in

0:28:35.800 --> 0:28:39.040
<v Speaker 7>the brain and replace the dead and dying cells with

0:28:39.160 --> 0:28:41.920
<v Speaker 7>new healthy cells, so you can slowly replace the brain

0:28:42.600 --> 0:28:45.800
<v Speaker 7>over time. Every time one of the cells in your

0:28:45.840 --> 0:28:49.920
<v Speaker 7>brain dies, we send a stem cell in there and

0:28:49.960 --> 0:28:52.960
<v Speaker 7>it replaces it with a new, younger, healthy cell.

0:28:59.280 --> 0:29:02.360
<v Speaker 1>What's fascinating about Nikoa is that he's actually tackling one

0:29:02.400 --> 0:29:05.520
<v Speaker 1>of the hardest problems in biotech. It's one thing to

0:29:05.560 --> 0:29:09.080
<v Speaker 1>coax stem cells into becoming skin or blood cells, or

0:29:09.120 --> 0:29:13.400
<v Speaker 1>even say a liver, things that have a very straightforward purpose.

0:29:14.400 --> 0:29:17.280
<v Speaker 1>It's another to get new cells across the blood brain

0:29:17.400 --> 0:29:20.880
<v Speaker 1>barrier into the right part of the brain, not to

0:29:20.960 --> 0:29:25.239
<v Speaker 1>mention doing it without disrupting the existing circuitry and the

0:29:25.280 --> 0:29:29.160
<v Speaker 1>person inside. But Nikoa is a rising star, and his

0:29:29.240 --> 0:29:32.120
<v Speaker 1>hope is that you can heal traumatic brain injuries and

0:29:32.160 --> 0:29:36.760
<v Speaker 1>replace damaged cells without the need for surgery. But also

0:29:37.360 --> 0:29:40.880
<v Speaker 1>he knows these advances take time because he knows just

0:29:40.960 --> 0:29:42.400
<v Speaker 1>how complicated the body is.

0:29:43.000 --> 0:29:44.480
<v Speaker 7>This is going to go on the record, right, so

0:29:44.480 --> 0:29:46.280
<v Speaker 7>I'll check back in ten more years. But I don't

0:29:46.320 --> 0:29:51.200
<v Speaker 7>think the predictions of curing all diseases using AI and

0:29:51.240 --> 0:29:54.280
<v Speaker 7>synthetic biology in ten more years are going to play

0:29:54.320 --> 0:29:58.520
<v Speaker 7>out in anywhere near the time span, because biology doesn't

0:29:58.560 --> 0:29:59.720
<v Speaker 7>move at machine speeds.

0:30:01.000 --> 0:30:03.680
<v Speaker 1>It's something I've been thinking about a lot, like there

0:30:03.720 --> 0:30:06.240
<v Speaker 1>is so much optimism and hype in the space, but

0:30:06.320 --> 0:30:08.800
<v Speaker 1>also there's a real tension between the people in the

0:30:08.920 --> 0:30:13.480
<v Speaker 1>university labs who believe advances take decades, people like doctor

0:30:13.560 --> 0:30:17.680
<v Speaker 1>Cy who is effectively replicating simplified brains in petri dishes,

0:30:18.320 --> 0:30:21.640
<v Speaker 1>from the tech optimists, people who are certain that death

0:30:21.760 --> 0:30:26.400
<v Speaker 1>with enough computing power is a very solvable problem.

0:30:26.600 --> 0:30:30.240
<v Speaker 7>I think tech teaches you to be optimistic and biotech

0:30:30.280 --> 0:30:34.880
<v Speaker 7>teaches you to be pessimistic. Here, when you're working with

0:30:35.000 --> 0:30:38.800
<v Speaker 7>living systems, you get used to things taking twice as

0:30:38.880 --> 0:30:41.120
<v Speaker 7>long and costing three times as much as you thought

0:30:41.400 --> 0:30:42.440
<v Speaker 7>every single time.

0:30:45.040 --> 0:30:48.440
<v Speaker 1>He's cautious about putting a neat timeline on biology, but

0:30:48.560 --> 0:30:51.560
<v Speaker 1>also just look at the scale of his ambition. He's

0:30:51.560 --> 0:30:56.120
<v Speaker 1>trying to replace an entire brain cell for cell, and

0:30:56.160 --> 0:31:00.160
<v Speaker 1>despite his caveats, Nicoa's Brain of THESEUS project is moving

0:31:00.200 --> 0:31:04.080
<v Speaker 1>at a surprisingly fast clip. He tells me that just

0:31:04.160 --> 0:31:04.960
<v Speaker 1>this year.

0:31:05.160 --> 0:31:09.680
<v Speaker 7>We're planning to launch our first pre clinical study in

0:31:09.720 --> 0:31:12.080
<v Speaker 7>an animal model of Alzheimer's to see if they can

0:31:12.120 --> 0:31:15.160
<v Speaker 7>actually reduce the burden of the disease.

0:31:16.480 --> 0:31:19.480
<v Speaker 1>Of course, the bigger question I have is the original

0:31:19.520 --> 0:31:23.520
<v Speaker 1>philosophical one. If you replace a brain sell by cell,

0:31:24.040 --> 0:31:25.680
<v Speaker 1>and at the end of it you have a totally

0:31:25.760 --> 0:31:30.000
<v Speaker 1>new brain, is that still you? Nikoa has a theory.

0:31:31.920 --> 0:31:35.760
<v Speaker 7>My conjecture is, because of how the brain works, even

0:31:35.760 --> 0:31:38.400
<v Speaker 7>if you replace every single cell in your brain over

0:31:38.440 --> 0:31:41.560
<v Speaker 7>time with a different cell, you're not going to lose

0:31:41.600 --> 0:31:46.600
<v Speaker 7>your identity because identity is encoded not in the individual neurons,

0:31:46.600 --> 0:31:50.320
<v Speaker 7>but in the patterns of firing between them. And every

0:31:50.360 --> 0:31:53.960
<v Speaker 7>time a new cell comes into your brain, it's trained

0:31:54.360 --> 0:31:57.560
<v Speaker 7>by all of the neurons next to it in order

0:31:57.600 --> 0:32:00.440
<v Speaker 7>to start behaving as part of your brain. So as

0:32:00.440 --> 0:32:03.760
<v Speaker 7>you get this gradual replacement, the parts that are there

0:32:04.000 --> 0:32:06.440
<v Speaker 7>train the new parts that are coming in, which train

0:32:06.560 --> 0:32:10.640
<v Speaker 7>their replacements, which train their replacements, and you eventually get

0:32:11.120 --> 0:32:15.560
<v Speaker 7>full replacement of your brain with healthy, er, younger sells,

0:32:16.360 --> 0:32:17.200
<v Speaker 7>but you're still you.

0:32:20.400 --> 0:32:22.120
<v Speaker 1>It's not an answer that would have occurred to me

0:32:22.440 --> 0:32:25.720
<v Speaker 1>that despite replacing your entire brain, you still might be

0:32:25.880 --> 0:32:29.120
<v Speaker 1>you at the end of it. And yet maybe that's

0:32:29.160 --> 0:32:31.880
<v Speaker 1>just how humans work because I'm not the person I

0:32:31.960 --> 0:32:35.680
<v Speaker 1>was as a kid, or even the person I was yesterday.

0:32:35.800 --> 0:32:40.040
<v Speaker 1>I have experiences that continuously change me. Our brains are

0:32:40.080 --> 0:32:44.840
<v Speaker 1>constantly changing. So maybe he's right. I don't know enough

0:32:44.880 --> 0:32:53.040
<v Speaker 1>to know if it's optimism or wishful thinking or just true.

0:32:56.480 --> 0:32:58.600
<v Speaker 1>I'm worried the trail has gone cold on the mystery.

0:32:58.640 --> 0:33:00.920
<v Speaker 1>I'd initially set out to solve the one about the

0:33:00.920 --> 0:33:04.720
<v Speaker 1>company making clones for organ farms, but before I go,

0:33:05.240 --> 0:33:08.120
<v Speaker 1>I decide to take a wild swing. I asked Nicole

0:33:08.200 --> 0:33:11.600
<v Speaker 1>if his brain, if theseus idea extends to the whole body,

0:33:12.240 --> 0:33:17.240
<v Speaker 1>and whether Putin's supposed goal of continual organ replacement is possible.

0:33:18.520 --> 0:33:20.720
<v Speaker 7>I don't think organ by organ is going to work

0:33:21.800 --> 0:33:25.920
<v Speaker 7>just because the environment has such a big impact. Like

0:33:26.000 --> 0:33:30.960
<v Speaker 7>you can take a day's zero embryonic cel but put

0:33:30.960 --> 0:33:34.840
<v Speaker 7>it in an old organism and it'll rapidly age just

0:33:34.840 --> 0:33:36.760
<v Speaker 7>because of all of the signals it's getting from the

0:33:36.840 --> 0:33:42.880
<v Speaker 7>older organism. So you see this with organs. Even if

0:33:42.880 --> 0:33:45.080
<v Speaker 7>you take an organ from a younger person, like a

0:33:45.160 --> 0:33:47.160
<v Speaker 7>kidney from a younger person, and put it into an

0:33:47.200 --> 0:33:52.040
<v Speaker 7>older person, it'll degrade in function to match the older

0:33:52.040 --> 0:33:54.880
<v Speaker 7>person's other kidney much more rapidly, just because it's in

0:33:54.920 --> 0:33:57.400
<v Speaker 7>an older, more damaging environment.

0:33:58.320 --> 0:34:00.840
<v Speaker 1>And then he says something i't expecting.

0:34:02.000 --> 0:34:09.000
<v Speaker 7>So I think, to get big gains from replacement, doing

0:34:09.080 --> 0:34:11.720
<v Speaker 7>as much replacement as possible, all at once.

0:34:13.120 --> 0:34:15.600
<v Speaker 1>And with those words, I realize he knows what I

0:34:15.600 --> 0:34:18.240
<v Speaker 1>want to know, because as I've been digging for clues

0:34:18.239 --> 0:34:22.279
<v Speaker 1>in Silicon Valley about the human cloning, about the organ replacement,

0:34:22.960 --> 0:34:27.120
<v Speaker 1>I've heard shades of exactly this language, doing as much

0:34:27.160 --> 0:34:31.160
<v Speaker 1>replacement as possible, all at once. So I asked Nicole

0:34:31.200 --> 0:34:33.880
<v Speaker 1>about the company. I only have a vague description of

0:34:34.800 --> 0:34:37.560
<v Speaker 1>if we're possibly talking about the same thing, and it

0:34:37.560 --> 0:34:39.719
<v Speaker 1>feels like we are, So I ask if he can

0:34:39.760 --> 0:34:42.759
<v Speaker 1>make an introduction for me, and he says he'll ask.

0:34:43.719 --> 0:34:46.719
<v Speaker 7>They sometimes don't like going on the record, just because

0:34:46.719 --> 0:34:47.799
<v Speaker 7>of the nature of what they do.

0:34:49.560 --> 0:35:10.719
<v Speaker 1>And then about a month later, I hear from Alice

0:35:11.400 --> 0:35:14.719
<v Speaker 1>Chapter four, Alice in monkey.

0:35:14.440 --> 0:35:26.200
<v Speaker 8>Land, I had a phenomenal lamp wreck at the hotel

0:35:26.239 --> 0:35:29.560
<v Speaker 8>that I'm staying at. I woke up at twelve, so

0:35:29.600 --> 0:35:33.360
<v Speaker 8>I decided to make it a brunch and it was great,

0:35:33.960 --> 0:35:35.200
<v Speaker 8>zero complaints.

0:35:35.560 --> 0:35:38.640
<v Speaker 1>Alice Gilman won't tell me where she is exactly, and

0:35:38.680 --> 0:35:41.240
<v Speaker 1>I can't really see her either. The room is dark

0:35:41.280 --> 0:35:44.239
<v Speaker 1>and I can only make out her shadow next to

0:35:44.280 --> 0:35:49.239
<v Speaker 1>the curtains billowing in the breeze, which adds to the mystique.

0:35:49.600 --> 0:35:51.960
<v Speaker 1>Alice is the co founder of the startup ar three bio,

0:35:52.400 --> 0:35:54.719
<v Speaker 1>and she's talking to me from a hotel somewhere in

0:35:54.760 --> 0:35:57.680
<v Speaker 1>the vicinity of their newest workspace on one of the

0:35:57.680 --> 0:36:00.560
<v Speaker 1>one hundred and forty three islands that make up Puerto Rico.

0:36:01.360 --> 0:36:03.720
<v Speaker 8>You know, working on a science project in an island.

0:36:03.880 --> 0:36:05.439
<v Speaker 8>People are like, what are you guys doing?

0:36:06.320 --> 0:36:10.120
<v Speaker 1>But I've been chasing a shadow for five months, and

0:36:10.200 --> 0:36:12.640
<v Speaker 1>I think I've finally found the person who belongs to

0:36:13.400 --> 0:36:16.680
<v Speaker 1>Alice and her company are three Bio, seem to operate

0:36:16.760 --> 0:36:22.160
<v Speaker 1>on that outermost ring where science kisses the impossible, and

0:36:22.239 --> 0:36:25.719
<v Speaker 1>up until this point in mid February twenty twenty six,

0:36:26.160 --> 0:36:29.080
<v Speaker 1>her company has been in stealth mode, a phrase I

0:36:29.200 --> 0:36:32.520
<v Speaker 1>keep hearing in Silicon Valley where people are very happy

0:36:32.520 --> 0:36:35.239
<v Speaker 1>to talk about their work but also pretend like it's

0:36:35.239 --> 0:36:38.560
<v Speaker 1>a secret. But those secrets have generated a lot of buzz.

0:36:39.840 --> 0:36:42.520
<v Speaker 8>I think that we're just like entertainingly a company that

0:36:42.920 --> 0:36:45.960
<v Speaker 8>is actually extremely boring, but a lot of people decided

0:36:46.000 --> 0:36:49.759
<v Speaker 8>that we are radically crazy.

0:36:51.280 --> 0:36:54.680
<v Speaker 1>As we talk, it's clear we're both walking on eggshells.

0:36:55.480 --> 0:36:57.239
<v Speaker 1>This is what I think I know about Alice.

0:36:57.400 --> 0:36:57.640
<v Speaker 6>One.

0:36:58.160 --> 0:37:03.560
<v Speaker 1>He's connected for the Residency and incubator, associated with Sam Altman.

0:37:04.239 --> 0:37:07.319
<v Speaker 1>She has spent time at Prospera, and she gives talks

0:37:07.320 --> 0:37:12.200
<v Speaker 1>to Adam Greeese's longevity conference Vitalist Pay. Two. There are

0:37:12.200 --> 0:37:17.200
<v Speaker 1>whispers about our three all over Silicon Valley, more than whispers,

0:37:17.200 --> 0:37:23.840
<v Speaker 1>actually palpable excitement, but there is very little online. And three.

0:37:24.000 --> 0:37:28.560
<v Speaker 1>She is not a scientist, She's an operator the COO.

0:37:28.960 --> 0:37:30.960
<v Speaker 1>But as I begin to ask her take on radical

0:37:31.000 --> 0:37:34.040
<v Speaker 1>life extension, she wants to start with the story of

0:37:34.080 --> 0:37:38.480
<v Speaker 1>her grandmother, a woman with an epic biography.

0:37:38.640 --> 0:37:41.239
<v Speaker 8>She escaped World War two, stole a horse from the

0:37:41.280 --> 0:37:43.640
<v Speaker 8>Nazis and got her three year old sister on a

0:37:43.719 --> 0:37:47.719
<v Speaker 8>horse across. She went from Germany to China basically over

0:37:47.840 --> 0:37:50.120
<v Speaker 8>like five years in them, ended up with Shaolin monks.

0:37:51.000 --> 0:37:54.000
<v Speaker 1>Alice grew up in Kazakhstan, spending time with her grandmother.

0:37:54.560 --> 0:37:57.560
<v Speaker 1>This woman who should have died but instead fought to

0:37:57.560 --> 0:38:00.799
<v Speaker 1>stay alive and now struggles in body she's in.

0:38:03.960 --> 0:38:06.400
<v Speaker 8>I'm like sitting in front of this person who's like

0:38:06.640 --> 0:38:09.800
<v Speaker 8>a legend, right, who's here playing with pills.

0:38:12.360 --> 0:38:16.000
<v Speaker 1>Alice tells me she can't stomach the disconnect. Why should

0:38:16.080 --> 0:38:19.359
<v Speaker 1>someone so full of life, so committed to life, have

0:38:19.480 --> 0:38:26.560
<v Speaker 1>to suffer just because their body is older? More than aging,

0:38:26.960 --> 0:38:31.319
<v Speaker 1>What terrifies Alice is death, because it wasn't so long

0:38:31.320 --> 0:38:34.280
<v Speaker 1>ago that she remembers sitting and waiting for news about

0:38:34.320 --> 0:38:35.600
<v Speaker 1>whether her father would live.

0:38:36.480 --> 0:38:40.399
<v Speaker 8>My dad had a open heart surgery. I got very

0:38:40.440 --> 0:38:45.120
<v Speaker 8>lucky my dad is still around. I made myself a

0:38:45.160 --> 0:38:47.960
<v Speaker 8>point of I want to make sure my dad gets

0:38:48.000 --> 0:38:50.560
<v Speaker 8>to live longer this decade. And I didn't find anything

0:38:50.920 --> 0:38:55.080
<v Speaker 8>technologically that would guarantee that this decade, so I decided

0:38:55.120 --> 0:38:56.279
<v Speaker 8>to help make it.

0:39:02.640 --> 0:39:05.799
<v Speaker 1>The experience drove Alice into the longevity space. She began

0:39:05.880 --> 0:39:08.640
<v Speaker 1>scouring for solutions scientists who might be able to help,

0:39:09.040 --> 0:39:12.200
<v Speaker 1>and then she finds a way to John Schloendorn, a

0:39:12.239 --> 0:39:16.960
<v Speaker 1>self proclaimed biological designer and PhD in molecular biology. He

0:39:17.000 --> 0:39:20.480
<v Speaker 1>counts Peter Teele as a benefactor. Teal invested and reported

0:39:20.600 --> 0:39:24.400
<v Speaker 1>one point five million dollars in one of Schlowendorn's previous startups.

0:39:25.440 --> 0:39:29.960
<v Speaker 8>I ended up meeting John, who's sitting there in his

0:39:29.960 --> 0:39:33.799
<v Speaker 8>little garage lab out in the middle of nowhere, and

0:39:34.160 --> 0:39:37.120
<v Speaker 8>I talked to him for a few hours and realized

0:39:37.160 --> 0:39:39.720
<v Speaker 8>that this guy can build things that no one can build.

0:39:40.200 --> 0:39:42.239
<v Speaker 8>And I informed him that I now work with him.

0:39:42.480 --> 0:39:44.600
<v Speaker 8>I've seen him do things in our lab that I'm

0:39:44.680 --> 0:39:48.000
<v Speaker 8>afraid to name because I think they sound like miracles.

0:39:48.880 --> 0:39:52.799
<v Speaker 1>Miracles. Whatever Alice saw convinced her that she and John

0:39:52.840 --> 0:39:55.120
<v Speaker 1>together could offer new solutions to the world.

0:39:55.960 --> 0:39:58.480
<v Speaker 8>We are making very strong statements and we can deliver

0:39:58.560 --> 0:40:01.920
<v Speaker 8>the extraordinary evidence. Someone called us the right hemisphere and

0:40:01.960 --> 0:40:03.200
<v Speaker 8>left hemisphere of real and musk.

0:40:03.320 --> 0:40:03.440
<v Speaker 3>Like.

0:40:03.600 --> 0:40:05.520
<v Speaker 8>One of our investors is like, yeah, you guys are

0:40:05.520 --> 0:40:08.080
<v Speaker 8>like a feeling musk was two separate people, and we're like, yeah,

0:40:08.239 --> 0:40:10.000
<v Speaker 8>that's not a bad branding. We'll take it.

0:40:10.480 --> 0:40:13.040
<v Speaker 1>She believes a partnership with John could be the ticket

0:40:13.080 --> 0:40:13.959
<v Speaker 1>to saving her dad.

0:40:14.680 --> 0:40:17.040
<v Speaker 8>So I'm like, wait, so could I grow him a

0:40:17.080 --> 0:40:19.560
<v Speaker 8>new heart that will never develop heart disease because I

0:40:19.680 --> 0:40:22.040
<v Speaker 8>genetically engineered it at like stage one?

0:40:22.880 --> 0:40:25.680
<v Speaker 1>And so Alice is in Puerto Rico at a bougie

0:40:25.719 --> 0:40:28.640
<v Speaker 1>hotel and near some type of monkey reserve. She wants

0:40:28.640 --> 0:40:32.120
<v Speaker 1>to grow replacement organs for people, better ones that will

0:40:32.160 --> 0:40:34.920
<v Speaker 1>never fall prey to disease like her dad's heart did

0:40:35.239 --> 0:40:35.480
<v Speaker 1>to me.

0:40:35.680 --> 0:40:39.960
<v Speaker 8>Tattoos are much more biologically damaging to the body than

0:40:40.040 --> 0:40:44.240
<v Speaker 8>like an organ transplant, because you're like eternally inflaming your

0:40:44.480 --> 0:40:48.080
<v Speaker 8>system forever, your body will be screaming in pain, right,

0:40:48.520 --> 0:40:51.799
<v Speaker 8>and so that is somehow normal to eternally have your

0:40:51.800 --> 0:40:55.440
<v Speaker 8>body screaming in pain, And like getting a heart transplant

0:40:55.520 --> 0:40:59.279
<v Speaker 8>is not normal somehow, right, Like what how did we

0:40:59.360 --> 0:40:59.919
<v Speaker 8>decide that?

0:41:01.480 --> 0:41:04.080
<v Speaker 1>But to get there, she can't just start with humans.

0:41:04.680 --> 0:41:08.840
<v Speaker 8>We have a few milestones that we're hoping to achieve.

0:41:08.960 --> 0:41:12.000
<v Speaker 8>The first milestone being we are working on replacing animal

0:41:12.040 --> 0:41:16.839
<v Speaker 8>testing by using skin stem cells. We take skin cells

0:41:16.840 --> 0:41:21.160
<v Speaker 8>from monkeys and we reprogram them and do some Yamanoca

0:41:21.160 --> 0:41:24.960
<v Speaker 8>miracles that result in fully grown organ systems.

0:41:25.600 --> 0:41:29.719
<v Speaker 1>The Yamanaka factors are these seemingly miraculous proteins that won

0:41:29.760 --> 0:41:33.920
<v Speaker 1>Shinya Yamanaka a Nobel prize. He and another scientist turned

0:41:33.920 --> 0:41:37.960
<v Speaker 1>adult cells into fresh stem cells, which can then be

0:41:38.040 --> 0:41:42.480
<v Speaker 1>reprogrammed to become any kind of cell. But what does

0:41:42.520 --> 0:41:45.560
<v Speaker 1>she mean by an organ system? In the course of

0:41:45.600 --> 0:41:48.640
<v Speaker 1>our conversation. She also calls these organ sacks.

0:41:49.320 --> 0:41:51.719
<v Speaker 8>So it's just pretty much a heart, like lungs and

0:41:51.800 --> 0:41:53.640
<v Speaker 8>everything that you would find in a body, but it's

0:41:53.680 --> 0:41:58.920
<v Speaker 8>not technically alive because it's exclusively the organs, and they

0:41:58.920 --> 0:42:01.640
<v Speaker 8>are kind of in this like little biological platform that

0:42:01.680 --> 0:42:03.279
<v Speaker 8>you can test on and you can map out the

0:42:03.360 --> 0:42:04.920
<v Speaker 8>cross organ interactions.

0:42:05.560 --> 0:42:11.440
<v Speaker 1>The language feels almost purposefully oblique. It's quote not technically alive.

0:42:11.920 --> 0:42:15.399
<v Speaker 1>It's everything quote you'd find in a body. It takes

0:42:15.440 --> 0:42:18.120
<v Speaker 1>me a while to piece together what Alice is talking about, because,

0:42:18.600 --> 0:42:20.719
<v Speaker 1>as Alice tells me, I.

0:42:21.440 --> 0:42:25.400
<v Speaker 8>Try to not be scary to an average person.

0:42:26.760 --> 0:42:30.480
<v Speaker 1>But what she's describing here, I finally figure out is

0:42:30.520 --> 0:42:34.120
<v Speaker 1>a shell of a body. A layperson like me might

0:42:34.200 --> 0:42:37.400
<v Speaker 1>call it as a clone. Alice and R three Bio

0:42:37.680 --> 0:42:42.239
<v Speaker 1>have called this quote immunocompatible organs grown out of your

0:42:42.280 --> 0:42:45.160
<v Speaker 1>skin cell, and the ones she's talking about as the

0:42:45.160 --> 0:42:48.799
<v Speaker 1>future of biological testing come from scraping skin cells from

0:42:48.840 --> 0:42:53.239
<v Speaker 1>a monkey. But the big difference, Alice claims, is that

0:42:53.440 --> 0:42:58.160
<v Speaker 1>R three would grow these without any sentience, meaning they

0:42:58.160 --> 0:43:01.480
<v Speaker 1>would use proprietary techniques to knock out the brain function

0:43:01.600 --> 0:43:05.200
<v Speaker 1>from inception so that the creatures would have no memory,

0:43:05.680 --> 0:43:11.399
<v Speaker 1>feel no pain, and have no consciousness, hence an organ sack.

0:43:18.239 --> 0:43:21.319
<v Speaker 1>But I'm curious, how do you get organ sacks that

0:43:21.480 --> 0:43:27.040
<v Speaker 1>grow but don't feel anything? So, like, do these organ

0:43:27.080 --> 0:43:29.279
<v Speaker 1>sacks like have the stem of a brain?

0:43:30.400 --> 0:43:34.960
<v Speaker 8>So the mice models can exist without any like like

0:43:35.000 --> 0:43:37.440
<v Speaker 8>with like a very limited set of nervous systems. But

0:43:37.760 --> 0:43:40.120
<v Speaker 8>then there are other constraints on the ability of like

0:43:40.120 --> 0:43:43.640
<v Speaker 8>the organs to preserve themselves. So there's a way in

0:43:43.680 --> 0:43:47.280
<v Speaker 8>which you can skew towards social acceptance and make less

0:43:47.280 --> 0:43:50.920
<v Speaker 8>nervous system And then when you skew towards social acceptance,

0:43:51.040 --> 0:43:54.160
<v Speaker 8>it looks better, but it's less scientifically feasible. Oh and

0:43:54.239 --> 0:43:57.000
<v Speaker 8>so we are still like making observations about how that

0:43:57.040 --> 0:43:57.600
<v Speaker 8>would work.

0:43:58.320 --> 0:44:01.440
<v Speaker 1>Alice is saying, less sentient the organ sack, the more

0:44:01.520 --> 0:44:04.799
<v Speaker 1>people are okay with it, but the science doesn't work

0:44:04.880 --> 0:44:08.680
<v Speaker 1>as well. The more sentient the test subject, the better

0:44:08.760 --> 0:44:13.520
<v Speaker 1>it works. But then it freaks everyone out and that

0:44:13.560 --> 0:44:17.320
<v Speaker 1>doesn't solve the unanswered scientific question about whether the clone

0:44:17.360 --> 0:44:22.680
<v Speaker 1>test subject would actually feel zero pain have zero sentience.

0:44:29.640 --> 0:44:31.839
<v Speaker 1>But Alice wants me to know this is sci fi

0:44:32.040 --> 0:44:32.720
<v Speaker 1>with a heart.

0:44:34.080 --> 0:44:36.480
<v Speaker 8>I'm a big animal rights advocate, and I believe in

0:44:37.480 --> 0:44:39.799
<v Speaker 8>making a better world, So I don't want to keep

0:44:39.840 --> 0:44:42.319
<v Speaker 8>monkeys in cages, and there's an option to have them

0:44:42.360 --> 0:44:46.480
<v Speaker 8>run around the island with bracelets on.

0:44:45.520 --> 0:44:48.560
<v Speaker 1>On its website. Our three Bio says we do not

0:44:48.719 --> 0:44:52.120
<v Speaker 1>work with live primates. Alice tells me the logic for

0:44:52.160 --> 0:44:53.520
<v Speaker 1>her being in Puerto Rico is.

0:44:54.320 --> 0:44:57.040
<v Speaker 8>We wanted monkey access, and there's a lot of monkeys

0:44:57.040 --> 0:45:00.560
<v Speaker 8>here that we can after negotiating with local companies that

0:45:00.719 --> 0:45:02.799
<v Speaker 8>are like supervising them, we can walk up to them

0:45:03.040 --> 0:45:04.600
<v Speaker 8>get some of their skin cells.

0:45:05.200 --> 0:45:09.600
<v Speaker 1>Wired magazine reported after our call that Gilman posted a

0:45:09.680 --> 0:45:13.880
<v Speaker 1>job listing for a veterinarian in Puerto Rico to quote

0:45:14.080 --> 0:45:20.239
<v Speaker 1>implant embryos, monitor pregnancies and help deliver healthy births in

0:45:20.360 --> 0:45:24.680
<v Speaker 1>non human primates. So I don't know, it seems like

0:45:24.719 --> 0:45:28.480
<v Speaker 1>they might start working with live primates. And also, just

0:45:28.520 --> 0:45:32.440
<v Speaker 1>to be clear, in today's world, with today's science, for

0:45:32.560 --> 0:45:36.360
<v Speaker 1>that organ sack to exist, some poor being has to

0:45:36.400 --> 0:45:44.960
<v Speaker 1>give birth to a brain dead offspring. But as Alice

0:45:45.080 --> 0:45:48.320
<v Speaker 1>keeps reminding me, she doesn't want to put living animals

0:45:48.320 --> 0:45:51.640
<v Speaker 1>in pain, and she doesn't see these organ sacks as

0:45:51.680 --> 0:45:54.879
<v Speaker 1>real monkeys, so she feels the ethics check out.

0:45:56.239 --> 0:45:59.320
<v Speaker 8>Hypothetically, so you imagine COVID hits. A bunch of AI

0:45:59.400 --> 0:46:02.400
<v Speaker 8>lab scientists already generate a hypothesis for what would be

0:46:02.400 --> 0:46:07.120
<v Speaker 8>a good vaccine and start infusing these little room cabinets

0:46:07.120 --> 0:46:10.480
<v Speaker 8>with these organ stacks, and in two hours we already

0:46:10.480 --> 0:46:13.279
<v Speaker 8>have reactions and they're like self recursive, so you can

0:46:13.360 --> 0:46:16.839
<v Speaker 8>keep updating whatever you're infusing into their body and like

0:46:16.960 --> 0:46:20.160
<v Speaker 8>check out what all the organ system reactions are creating.

0:46:20.719 --> 0:46:23.160
<v Speaker 8>By the time the first scientist walks in at six am,

0:46:23.760 --> 0:46:26.760
<v Speaker 8>you already have basically multiple proof of concepts for vaccines,

0:46:27.120 --> 0:46:29.480
<v Speaker 8>and we could actually have a COVID vaccine in two weeks.

0:46:38.360 --> 0:46:41.880
<v Speaker 1>The scene feels like pure science fiction. Cabinets full of

0:46:41.920 --> 0:46:45.920
<v Speaker 1>allegedly non sentient monkey bodies hooked up to AI, ready

0:46:45.960 --> 0:46:50.120
<v Speaker 1>to test for lightning fast medical advances. Instead of a

0:46:50.200 --> 0:46:54.279
<v Speaker 1>year and change in lockdown. In Alice's world, complex vaccines

0:46:54.360 --> 0:46:59.759
<v Speaker 1>are just a few weeks away. That image is overwhelming.

0:47:00.680 --> 0:47:03.840
<v Speaker 1>You know that William Gibson quote, The future is already here,

0:47:04.000 --> 0:47:07.799
<v Speaker 1>it's just not evenly distributed. Alice is forcing me to

0:47:07.840 --> 0:47:11.920
<v Speaker 1>confront a sci fi present. I didn't know existed and

0:47:12.000 --> 0:47:14.840
<v Speaker 1>now I'm trying to get my bearings.

0:47:16.520 --> 0:47:18.640
<v Speaker 8>This could mean things like designer organs, and now we

0:47:18.719 --> 0:47:22.560
<v Speaker 8>can have Olympic lungs, and we can have extremely healthy

0:47:22.640 --> 0:47:25.719
<v Speaker 8>organs where your genetics actually you know, your whole liver

0:47:25.800 --> 0:47:28.640
<v Speaker 8>is going to consist of like cells that are from

0:47:28.680 --> 0:47:31.040
<v Speaker 8>the beginning program to not form any diseases.

0:47:31.520 --> 0:47:34.240
<v Speaker 1>Vcs and scientists in Silicon Valley have also been telling

0:47:34.239 --> 0:47:37.200
<v Speaker 1>me that when autonomous cars take over, car crashes will

0:47:37.200 --> 0:47:40.160
<v Speaker 1>go down and the number of legitimate organs available for

0:47:40.280 --> 0:47:45.560
<v Speaker 1>donation will decrease significantly. To keep humans alive, these organs

0:47:45.560 --> 0:47:50.000
<v Speaker 1>will need to come from somewhere. So why not organ bags.

0:47:50.360 --> 0:47:53.399
<v Speaker 8>Say we grew a set of human organs and say,

0:47:53.480 --> 0:47:56.359
<v Speaker 8>like a rich person orders a heart, we still have

0:47:56.600 --> 0:47:59.840
<v Speaker 8>all of the other organs. There is nothing stopping me

0:48:00.040 --> 0:48:02.680
<v Speaker 8>from donating the rest of them to someone who needs

0:48:02.680 --> 0:48:05.000
<v Speaker 8>them in a wait list of one hundred thousand people

0:48:05.280 --> 0:48:10.160
<v Speaker 8>instead of a car accident or a suicide.

0:48:15.040 --> 0:48:17.840
<v Speaker 1>Alice blames the media for making people feel scared of

0:48:17.880 --> 0:48:22.120
<v Speaker 1>the future when there are solutions around the corner. Remember

0:48:22.640 --> 0:48:24.080
<v Speaker 1>she's half an Elon Musk.

0:48:25.760 --> 0:48:29.760
<v Speaker 8>People hating on billionaires for investing in anti aging makes

0:48:30.040 --> 0:48:33.160
<v Speaker 8>people want to hide working on anti aging and like

0:48:33.400 --> 0:48:37.359
<v Speaker 8>the whiplash you get just for working on something scientific

0:48:37.680 --> 0:48:41.480
<v Speaker 8>because of the propaganda that people see that was filmed

0:48:41.480 --> 0:48:44.520
<v Speaker 8>by people who were also potentially genuinely afraid of the future.

0:48:45.800 --> 0:48:48.680
<v Speaker 8>I think is kind of a gap I'm noticing between

0:48:48.719 --> 0:48:52.520
<v Speaker 8>the rest of the world and the Silicon Valley.

0:48:52.680 --> 0:48:56.840
<v Speaker 1>She feels compelled to keep pushing humanity forward because the

0:48:56.880 --> 0:49:00.160
<v Speaker 1>way she sees it, there's limited downside.

0:49:00.840 --> 0:49:04.080
<v Speaker 8>Worst case scenarios. I say, millions of lives, and to me,

0:49:04.160 --> 0:49:07.200
<v Speaker 8>that is a be worth taking, regardless of any kinds

0:49:07.200 --> 0:49:08.640
<v Speaker 8>of blows that are going to come our way.

0:49:10.239 --> 0:49:14.480
<v Speaker 1>I noticed that whenever we start talking about ethics or feasibility,

0:49:15.040 --> 0:49:18.040
<v Speaker 1>she sways the conversation to how much good R three

0:49:18.080 --> 0:49:21.040
<v Speaker 1>is doing, or about not putting cute monkeys in pain,

0:49:21.200 --> 0:49:24.880
<v Speaker 1>or the cows and Cowshwitz an animal rights term for

0:49:24.960 --> 0:49:26.280
<v Speaker 1>factory farms.

0:49:26.760 --> 0:49:29.799
<v Speaker 8>I live in a contextual world where just because we

0:49:29.840 --> 0:49:32.279
<v Speaker 8>don't talk about a lot of things, that doesn't mean

0:49:32.320 --> 0:49:35.120
<v Speaker 8>they're not happening.

0:49:36.440 --> 0:49:39.239
<v Speaker 1>I feel like I'm on the receiving end of debate tactics,

0:49:39.560 --> 0:49:43.200
<v Speaker 1>though I don't know. I wasn't on the debate club,

0:49:43.600 --> 0:49:46.440
<v Speaker 1>but I was on the high school newspaper, and I

0:49:46.560 --> 0:49:50.840
<v Speaker 1>do know how to press gently for facts. So fifty

0:49:50.840 --> 0:49:53.239
<v Speaker 1>five minutes into our call, I just decided to talk

0:49:53.239 --> 0:49:57.680
<v Speaker 1>about it. This idea. I keep hearing this persistent rumor

0:49:57.680 --> 0:50:01.960
<v Speaker 1>in Silicon Valley that there are people, maybe r through bio,

0:50:02.040 --> 0:50:05.839
<v Speaker 1>working to make nonsentient clones of people's bodies. So then

0:50:05.880 --> 0:50:08.680
<v Speaker 1>when your body at seventy or eighty or whenever has

0:50:08.760 --> 0:50:11.799
<v Speaker 1>outgrown its use, you can snap your head onto a

0:50:11.840 --> 0:50:16.840
<v Speaker 1>younger version of yourself. The more I talked to people

0:50:17.800 --> 0:50:22.360
<v Speaker 1>in San Francisco about it, the more I heard people say, like,

0:50:23.080 --> 0:50:27.080
<v Speaker 1>transferring one organ just isn't efficient, and ultimately, like a

0:50:27.239 --> 0:50:30.520
<v Speaker 1>surgical like cut for where where you replace a head

0:50:30.520 --> 0:50:32.920
<v Speaker 1>on a new body is actually much much more efficient

0:50:33.400 --> 0:50:36.799
<v Speaker 1>and you're not asking an organ to adapt to like

0:50:37.200 --> 0:50:38.880
<v Speaker 1>the circumstances of a body.

0:50:39.480 --> 0:50:42.760
<v Speaker 8>Well, if I was to join you in your Sciphi

0:50:42.800 --> 0:50:45.400
<v Speaker 8>speculations of the future, as long as we can figure

0:50:45.440 --> 0:50:50.560
<v Speaker 8>out surgical infrastructure, it would be I would take I

0:50:50.600 --> 0:50:54.520
<v Speaker 8>would probably be open to living in a younger, healthier

0:50:54.680 --> 0:50:56.959
<v Speaker 8>set of organs in the future, and I think that's

0:50:57.000 --> 0:50:59.080
<v Speaker 8>a desirable thing to have in the world.

0:51:00.320 --> 0:51:01.680
<v Speaker 1>She keeps bringing it up.

0:51:03.560 --> 0:51:06.640
<v Speaker 8>Would you get a new body if you wouldn't a

0:51:06.680 --> 0:51:10.000
<v Speaker 8>younger one?

0:51:10.320 --> 0:51:14.600
<v Speaker 1>And then this about full body replacements. And I also

0:51:14.600 --> 0:51:18.240
<v Speaker 1>think that, like as you pointed out earlier, the ways

0:51:18.320 --> 0:51:23.160
<v Speaker 1>that we embrace change is very slow. Right, Like the

0:51:23.239 --> 0:51:27.040
<v Speaker 1>idea of getting a heart transplant initially was so foreign.

0:51:28.960 --> 0:51:32.120
<v Speaker 8>I think head transplants are definitely a scary way of

0:51:32.480 --> 0:51:37.520
<v Speaker 8>thinking about the future. Right. It feels like either like

0:51:37.560 --> 0:51:39.279
<v Speaker 8>it sounds like a lot of people are going to

0:51:39.360 --> 0:51:41.799
<v Speaker 8>be taken advantage of, and this is something either only

0:51:41.840 --> 0:51:44.200
<v Speaker 8>available to the ridge but also somehow very horrible and

0:51:44.239 --> 0:51:46.440
<v Speaker 8>four people are going to be taken advantage of, and

0:51:46.520 --> 0:51:49.919
<v Speaker 8>like it just creates an ick. And so that's one

0:51:49.960 --> 0:51:52.080
<v Speaker 8>example of like, no, we're not doing that.

0:51:52.120 --> 0:52:00.560
<v Speaker 1>By the way, the thing is, I can't say head

0:52:00.560 --> 0:52:04.319
<v Speaker 1>transplants or what Alice is working towards. I can't say

0:52:04.360 --> 0:52:08.040
<v Speaker 1>that a company in stealth mode whose chief operating officer

0:52:08.520 --> 0:52:11.080
<v Speaker 1>tells me that it's working towards an organ sack of

0:52:11.120 --> 0:52:14.480
<v Speaker 1>a monkey with aspirations of making an organ sack of

0:52:14.520 --> 0:52:18.200
<v Speaker 1>a human might want to sell you a clone so

0:52:18.239 --> 0:52:20.920
<v Speaker 1>you can avoid death by cutting off your head and

0:52:21.040 --> 0:52:28.319
<v Speaker 1>implanting it on a younger you. But the MIT Technology

0:52:28.440 --> 0:52:33.279
<v Speaker 1>Review did because when they released a story in late

0:52:33.360 --> 0:52:36.799
<v Speaker 1>March this year, over a month after I chat with Alice,

0:52:36.960 --> 0:52:37.960
<v Speaker 1>they found this.

0:52:39.320 --> 0:52:39.800
<v Speaker 5>Quote.

0:52:40.040 --> 0:52:44.080
<v Speaker 1>Last September, Alice and her co founder John Schlowandorn presented

0:52:44.200 --> 0:52:48.120
<v Speaker 1>at Abundance Longevity, a seventy thousand dollars per ticket event

0:52:48.200 --> 0:52:52.120
<v Speaker 1>in Boston, and while that presentation was meant to be confidential,

0:52:52.360 --> 0:52:56.120
<v Speaker 1>the article alleges the agenda leaked the name of our

0:52:56.200 --> 0:53:10.360
<v Speaker 1>three session quote full body replacement. Alice and I talked

0:53:10.360 --> 0:53:12.920
<v Speaker 1>for an hour and forty five minutes, but now it's

0:53:12.960 --> 0:53:13.680
<v Speaker 1>time for her to go.

0:53:14.560 --> 0:53:17.520
<v Speaker 8>I think we covered a lot of it. I wish

0:53:17.560 --> 0:53:20.520
<v Speaker 8>people knew the perspective of how hard it is sometimes

0:53:20.520 --> 0:53:24.160
<v Speaker 8>to be guiding a company based on like a moral compass,

0:53:24.320 --> 0:53:27.440
<v Speaker 8>like we would be triple funded if we were not

0:53:27.600 --> 0:53:35.360
<v Speaker 8>making decisions with certain moralities attacked. And I hope people

0:53:35.400 --> 0:53:38.840
<v Speaker 8>get really excited about things that will save hundreds of

0:53:38.840 --> 0:53:42.920
<v Speaker 8>millions of people's lives and explore and how to scale that.

0:53:44.400 --> 0:53:47.200
<v Speaker 8>And I love all these intelligences in the world, and

0:53:47.239 --> 0:53:49.560
<v Speaker 8>I hope that we can make a world better for

0:53:49.640 --> 0:53:53.320
<v Speaker 8>all forms of intelligences and people to live healthier longer

0:53:53.360 --> 0:53:56.480
<v Speaker 8>lives and think about infrastructure in more efficient ways.

0:54:00.160 --> 0:54:04.160
<v Speaker 1>Some important points here. Our three Bio rejected the claims

0:54:04.160 --> 0:54:08.000
<v Speaker 1>in the MIT Technology Review, giving the following repudiation to

0:54:08.040 --> 0:54:12.600
<v Speaker 1>the outlet quote, any allegations of intent or conspiracy to

0:54:12.640 --> 0:54:16.200
<v Speaker 1>create human clones or human beings with brain damage are

0:54:16.400 --> 0:54:20.719
<v Speaker 1>categorically false. Alice did share with me a piece she

0:54:20.880 --> 0:54:24.200
<v Speaker 1>liked better. That article m wired with a quote about

0:54:24.200 --> 0:54:27.359
<v Speaker 1>the veterinarian posting. It came out days before the MIT

0:54:27.560 --> 0:54:30.799
<v Speaker 1>Tech Review piece. It still focuses on their work with

0:54:30.880 --> 0:54:34.120
<v Speaker 1>monkey skin cells, organ sacks for testing and transplants, and

0:54:34.160 --> 0:54:37.560
<v Speaker 1>it even quotes an our three Bio investor saying, quote,

0:54:37.760 --> 0:54:41.640
<v Speaker 1>if we can create a non sentient, headless bodyoid for

0:54:41.680 --> 0:54:46.920
<v Speaker 1>a human being, that will be a great source of organs. Also,

0:54:47.000 --> 0:54:48.840
<v Speaker 1>the week before this episode came out, we did a

0:54:48.880 --> 0:54:51.040
<v Speaker 1>fact check and call with Alice. She asked us if

0:54:51.040 --> 0:54:54.200
<v Speaker 1>we could postpone the episode. We declined. She told us

0:54:54.360 --> 0:54:57.719
<v Speaker 1>all of this is theoretical and just her opinion. She

0:54:58.000 --> 0:55:00.920
<v Speaker 1>also wants us to know that our three BI isn't

0:55:01.000 --> 0:55:05.600
<v Speaker 1>working on organ sacks quote for now period. What are

0:55:05.640 --> 0:55:09.560
<v Speaker 1>they doing? She won't say, though she did start the

0:55:09.560 --> 0:55:12.279
<v Speaker 1>fact check and call by letting us know r III

0:55:12.440 --> 0:55:21.600
<v Speaker 1>is now quote a federal asset. For me, the whole

0:55:21.680 --> 0:55:24.520
<v Speaker 1>thing is a head trip. I started this quest trying

0:55:24.560 --> 0:55:27.799
<v Speaker 1>to track down a rumor. Who was this company that

0:55:27.880 --> 0:55:30.479
<v Speaker 1>had pitched investors on funding a business with a dream

0:55:30.520 --> 0:55:34.759
<v Speaker 1>of full body replacement. After a lot of digging, I

0:55:34.760 --> 0:55:37.200
<v Speaker 1>think it's fair to say we found it, and I

0:55:37.200 --> 0:55:39.359
<v Speaker 1>heard the way one of its co founders talks about

0:55:39.400 --> 0:55:43.319
<v Speaker 1>the future. Here's what I can tell you. The technology

0:55:43.400 --> 0:55:47.040
<v Speaker 1>is nowhere near close to the promise, at least not yet.

0:55:47.280 --> 0:55:51.640
<v Speaker 1>There are so many milestones, and for right now, even

0:55:51.640 --> 0:55:55.640
<v Speaker 1>the first ones, those organ sacks made from monkey skin

0:55:55.719 --> 0:56:00.319
<v Speaker 1>cells are all theoretical. I still don't know how to

0:56:00.360 --> 0:56:03.040
<v Speaker 1>answer Alice's question, wouldn't you want to live in a

0:56:03.080 --> 0:56:05.319
<v Speaker 1>younger body? I don't even know how to live in

0:56:05.320 --> 0:56:09.360
<v Speaker 1>a world where that is a question, because the answer

0:56:09.440 --> 0:56:19.719
<v Speaker 1>is maybe, but not that way. Sherlock Holmes always sank

0:56:19.800 --> 0:56:23.640
<v Speaker 1>back into an ui, what he called the dull routine

0:56:23.640 --> 0:56:28.440
<v Speaker 1>of existence whenever a case ended. And that's kind of

0:56:28.480 --> 0:56:32.719
<v Speaker 1>where I am feeling unsatisfied and a little creeped out,

0:56:32.800 --> 0:56:36.120
<v Speaker 1>because I thought I was in a detective case, but

0:56:36.960 --> 0:56:40.120
<v Speaker 1>I was really in a sci fi novel, and all

0:56:40.120 --> 0:56:43.200
<v Speaker 1>I can think is what I always think when I'm lost.

0:56:44.440 --> 0:56:52.440
<v Speaker 1>I just need to get home next time on how

0:56:52.480 --> 0:56:53.200
<v Speaker 1>to live forever.

0:56:54.360 --> 0:56:57.480
<v Speaker 3>What our ancestors were eating five hundred years ago may

0:56:57.520 --> 0:57:00.000
<v Speaker 3>have worked really well for them, but then our biology

0:57:00.160 --> 0:57:19.680
<v Speaker 3>was perturbed by two hundred years of trauma.

0:57:22.440 --> 0:57:24.760
<v Speaker 1>Let's do the credit. Skyline Drive is a production of

0:57:24.800 --> 0:57:28.800
<v Speaker 1>Kaleidoscope and iHeart Podcast. This show is hosted and written

0:57:28.840 --> 0:57:34.080
<v Speaker 1>by Me Mongage Artigulu, but I could never do this alone.

0:57:34.280 --> 0:57:36.480
<v Speaker 1>The show is story edited by Mark Lotto, who told

0:57:36.520 --> 0:57:39.600
<v Speaker 1>me to indulge my inner Encyclopedia Brown for this one.

0:57:39.840 --> 0:57:43.600
<v Speaker 1>Lizzie Jacobs, my partner in solving crimes, is the EP

0:57:43.840 --> 0:57:46.400
<v Speaker 1>on the show. I also have massive, massive help from

0:57:46.440 --> 0:57:49.640
<v Speaker 1>the only kid who loved Sherlock Holmes more than me,

0:57:49.960 --> 0:57:54.040
<v Speaker 1>Mary Philip Sandy, and our international man of Mystery science

0:57:54.120 --> 0:57:59.000
<v Speaker 1>producer Mark Stephen Allen. This episode was mixed by Casey

0:57:59.120 --> 0:58:02.280
<v Speaker 1>Holford As who also worked on the first season of Skyline.

0:58:02.320 --> 0:58:06.200
<v Speaker 1>Thank you so much, Casey, with beautiful music from Botany Bliss,

0:58:06.240 --> 0:58:09.800
<v Speaker 1>Samsa and the Zadi Records. We are so lucky to

0:58:09.880 --> 0:58:11.880
<v Speaker 1>have these tunes. If you want to hear more we

0:58:11.920 --> 0:58:14.600
<v Speaker 1>made you mixtape. Just check out the show notes. This

0:58:14.720 --> 0:58:17.080
<v Speaker 1>show is executive produced from My Heart, but my good

0:58:17.120 --> 0:58:20.560
<v Speaker 1>friends Ali Perry and Katrina Norvel from Kaleidoscope. We've got

0:58:20.560 --> 0:58:24.920
<v Speaker 1>my co founder Oswold Listen also cost Us Lina's cost us.

0:58:24.960 --> 0:58:26.960
<v Speaker 1>How could you leave us for Greece? We are going

0:58:27.040 --> 0:58:30.840
<v Speaker 1>to miss you enjoy so much. Julia Nutter Our head

0:58:30.840 --> 0:58:34.040
<v Speaker 1>of studio, Rachel Strom our wonderful lawyer and friend who

0:58:34.520 --> 0:58:37.360
<v Speaker 1>somehow reviewed this episode and made it to the front

0:58:37.360 --> 0:58:41.080
<v Speaker 1>page of the Liberties Instagram that in itself is a mystery. Also,

0:58:41.280 --> 0:58:44.680
<v Speaker 1>thank you to the team here, Christy David, Dara Agne,

0:58:44.800 --> 0:58:49.400
<v Speaker 1>Sheina calypso El Viney for the beautiful collage art. There

0:58:49.440 --> 0:58:52.120
<v Speaker 1>are so many of you. I also want to give

0:58:52.120 --> 0:58:55.200
<v Speaker 1>a little special thanks to all the kiddos out there,

0:58:55.400 --> 0:59:01.320
<v Speaker 1>Henry Ruby, Julian Brendel, lou Baby, leon Enzo and Pearl Etour.

0:59:01.840 --> 0:59:04.560
<v Speaker 1>You guys make us so happy. All my friends at iHeart,

0:59:04.560 --> 0:59:08.560
<v Speaker 1>including Bob Connell, Will, Carrie, Nikki, Jason, Jerry and Moore,

0:59:08.920 --> 0:59:12.600
<v Speaker 1>also Shanta and Sarah, my family in India, my family

0:59:12.600 --> 0:59:16.280
<v Speaker 1>in the States, my cousin Roshni and Rohan, who promoted

0:59:16.360 --> 0:59:19.960
<v Speaker 1>us to first cousins because of Carmen San Diego. The

0:59:20.080 --> 0:59:23.160
<v Speaker 1>very biggest thanks to Lucas Adams, founder and editor of

0:59:23.200 --> 0:59:25.200
<v Speaker 1>The New York Review of Comics, and the person who

0:59:25.240 --> 0:59:28.720
<v Speaker 1>introduced me to the Hot Rock and the wonderful Donald

0:59:28.800 --> 0:59:33.680
<v Speaker 1>Westlake Mysteries books that made me smile wide. A very

0:59:33.720 --> 0:59:36.760
<v Speaker 1>big thank you to my cousin and our family playwright

0:59:36.840 --> 0:59:40.800
<v Speaker 1>Akshay Srivastov, and also to his dog Dimmy, just because

0:59:40.800 --> 0:59:44.720
<v Speaker 1>he's also great. And thank you to our pal Natalia Fiddleholts,

0:59:44.840 --> 0:59:49.400
<v Speaker 1>who also lent us her acting chops. Thank you so much, Natalia.

0:59:49.800 --> 0:59:52.440
<v Speaker 1>Just one last thank you to my Amma and my

0:59:52.600 --> 0:59:55.800
<v Speaker 1>dad Lalita and Omesha Ticular who let me stay up

0:59:55.880 --> 0:59:59.200
<v Speaker 1>so late and ordered pizza and we would watch Mysteries

0:59:59.200 --> 1:00:03.520
<v Speaker 1>together even though I had school the next day. Thank

1:00:03.600 --> 1:00:04.720
<v Speaker 1>you so much for listening