WEBVTT - Ep 212 Burns Part 1: The first million or so years

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<v Speaker 1>This episode features descriptions that some listeners might find upsetting.

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<v Speaker 1>Please listen with discretion. Case one, a lady aged twenty

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<v Speaker 1>years in feeble health was extensively burned by her mosquito

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<v Speaker 1>curtains and calico bed cover being set on fire after

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<v Speaker 1>she had fallen asleep. The flames enveloped her head, neck,

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<v Speaker 1>and arms, and were not extinguished for twenty or thirty seconds.

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<v Speaker 1>Ardent spirits were first applied, then flaxied oil, and lastly

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<v Speaker 1>a calcareous soap of the same oil and lime water laudanum,

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<v Speaker 1>was administered freely, both externally and internally.

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<v Speaker 2>Case two.

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<v Speaker 1>The editor, while rescuing the patient described in case one,

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<v Speaker 1>was severely burnt on both hands from compressing the burning

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<v Speaker 1>clothes with his bare hands until the flames were extinguished.

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<v Speaker 1>The cuticle exfoliated from nearly the whole right hand, and

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<v Speaker 1>the cutis vera sloughed in seven places. The left hand

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<v Speaker 1>suffered much worse. The whole cuticle was separated and much

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<v Speaker 1>of it was rolled up, especially that which covered the

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<v Speaker 1>space between the wrist and hollow of the hand and

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<v Speaker 1>extended up the inner side of the thumb as far

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<v Speaker 1>as the middle of the second phalanx between these limits

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<v Speaker 1>and the metacarpal bone of the little finger on one

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<v Speaker 1>side and the corresponding bone of the thumb on the other.

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<v Speaker 1>The true skin was killed and turned black. Immediately after

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<v Speaker 1>the accident. He immersed both hands in whiskey, then in

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<v Speaker 1>a liniment of flaxeied oil and lime water, after which

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<v Speaker 1>the affected parts were wrapped in rags dipped in a

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<v Speaker 1>painter's mixture of the same kind of oil and white lead,

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<v Speaker 1>ground together.

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<v Speaker 2>In three days.

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<v Speaker 1>This was replaced by carrot poultices with yeast and peruvian bark,

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<v Speaker 1>the deeply burnt parts being stimulated at different times with

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<v Speaker 1>tincture of mir oil of turpentine, ammoniated alcohol, and other excitents.

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<v Speaker 1>After a few days, separation was established and the dead

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<v Speaker 1>skin sloughed off. Had the case presented nothing but what

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<v Speaker 1>has been stated, a report of it would have been

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<v Speaker 1>of little interest. There resulted, however, from this local injury,

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<v Speaker 1>a great constitutional disturbs, And to this I beg leave

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<v Speaker 1>to direct the attention of the reader. Several causes seem

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<v Speaker 1>to have conspired to depress the energy and disorder the

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<v Speaker 1>sensibilities of his nervous system. Number one, the acute sensibility

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<v Speaker 1>of the parts injured. The pain for several hours after

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<v Speaker 1>the accident was excruciating, notwithstanding the liberal use of laudanum.

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<v Speaker 1>Number two, the scene of concentrated horror under which the

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<v Speaker 1>injury was inflicted contributed not a little to overthrow the

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<v Speaker 1>powers of the nervous system. Number three. The immersion of

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<v Speaker 1>both hands extensively denuded of cuticle in a liniment of

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<v Speaker 1>oil and white lead, seems to me to have contributed

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<v Speaker 1>largely to the same effect. Number four.

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<v Speaker 3>Two.

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<v Speaker 1>Three or four days after the accident, when febrile symptoms

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<v Speaker 1>were developed, the patient, by his own advice, lost about

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<v Speaker 1>ten ounces of blood. This was done under the apprehension

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<v Speaker 1>that the fever and inflammation might run too high for

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<v Speaker 1>healthy separation, but it manifestly did harm. It would be

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<v Speaker 1>difficult to set forth the variety of physical and moral

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<v Speaker 1>suffering which were attendant on the protracted state of nervous

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<v Speaker 1>or constitutional irritation which these causes generated. A great variety

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<v Speaker 1>of applications were advised and employed for this formidable affection,

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<v Speaker 1>but with little good time only has been efficacious. But

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<v Speaker 1>even a period of nearly two years has not entirely

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<v Speaker 1>overcome the effect.

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<v Speaker 4>I can't believe that they survived.

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<v Speaker 2>Yeah, yes, I know, uh so that it is.

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<v Speaker 5>It is.

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<v Speaker 2>It's horrible.

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<v Speaker 1>It's horrible, and it exhibits I think there are some

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<v Speaker 1>it's There's an entire paper actually that I found this

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<v Speaker 1>in that was like discussing, uh what this represents in

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<v Speaker 1>terms of the history of burned treatment and where things stood.

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<v Speaker 1>So the author of that was a medical doctor named

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<v Speaker 1>Daniel Drake, who was actually one of like a famous

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<v Speaker 1>doctor at the time, and he wrote this about his

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<v Speaker 1>own experience, and he was the editor of a journal,

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<v Speaker 1>and he was like, I need to tell everyone about this,

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<v Speaker 1>like all of these and I think the realization that

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<v Speaker 1>he came to was, like all of these treatments. We

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<v Speaker 1>have so many different treatments and none seem to have

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<v Speaker 1>a positive effect.

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<v Speaker 4>Like, if anything, they might have made things worse. Yes. Yeah.

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<v Speaker 1>The article, if you're interested, is titled History of two

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<v Speaker 1>Cases of burn producing Serious Constitutional Irritations by Daniel Drake.

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<v Speaker 1>It was published in eighteen thirty. And the paper that

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<v Speaker 1>I found this in was called Daniel Drake's Account of

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<v Speaker 1>his Own hand Burns by Eric Mooney that was published

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<v Speaker 1>in like nineteen ninety eight. I think so yeah, truly

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<v Speaker 1>awful stuff. But Hi, I'm erin Welsh.

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<v Speaker 3>And I'm erin aman Upnike and this is this podcast

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<v Speaker 3>will kill you.

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<v Speaker 4>Welcome to Burns. Yeah, part one, Part one, two parts,

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<v Speaker 4>because this is a big this is a big one.

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<v Speaker 1>I mean each there are as I was working on

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<v Speaker 1>the second episode and like the way that I split

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<v Speaker 1>up the history for this is that I did, like

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<v Speaker 1>most of history, most of history, stand right, most of everything,

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<v Speaker 1>and then like the last eighty years basically, and like

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<v Speaker 1>the various developments in the last eighty years, each one

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<v Speaker 1>of those could be its own episode, not to mention

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<v Speaker 1>burn Centers being its own episode, multidisciplinary like all these things.

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<v Speaker 4>Anyway, I know, there's so there's so much and like

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<v Speaker 4>even in the newer like the techniques and the newer

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<v Speaker 4>technologies and things that we have, Like there's so much

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<v Speaker 4>more detail that we listen. We've got a lot to

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<v Speaker 4>cover though today and next week. Yes, today is Burns

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<v Speaker 4>Part one. Should we tell people like kind of what

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<v Speaker 4>we're covering today, what we're covering next week? Sure? Sure,

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<v Speaker 4>let them know a little biting to I don't know,

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<v Speaker 4>if you want to know.

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<v Speaker 2>Here's a preview.

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<v Speaker 4>Here's a preview. Today, we're going to talk about the

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<v Speaker 4>biology of burns, what is happening in our bodies to

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<v Speaker 4>our bodies when we suffer a burn, and then Aaron,

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<v Speaker 4>you're going to walk us through, like you said, the

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<v Speaker 4>most of humans's history with burns, and then next week

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<v Speaker 4>we're going to pick up with more modern history and

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<v Speaker 4>how we actually treat and deal with burns. Today.

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<v Speaker 2>Yeah, yeah, there's a lot. There's a lot. There's a lot.

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<v Speaker 2>And before we can do any.

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<v Speaker 4>Of this, it is quarantine time any time.

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<v Speaker 2>What are we drinking this week?

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<v Speaker 4>We're drinking by degrees? By degrees it is technically still

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<v Speaker 4>how we measure burns is ish okay, okay, ish, we'll

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<v Speaker 4>get there, but kind of okay okay. It's still all

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<v Speaker 4>over the literature.

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<v Speaker 1>It is when when I was like, oh, degrees and

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<v Speaker 1>you were like, no, we don't talk about that anymore,

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<v Speaker 1>it's like it's fine, We're going to okay, okay, okay. Well,

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<v Speaker 1>by degrees is the name of the quarantini, and the

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<v Speaker 1>quarantini is a non alcoholic bee's knees basically, so some

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<v Speaker 1>non alcoholic gin. Lots of different varieties out there, take

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<v Speaker 1>your pick. Lemon juice honey.

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<v Speaker 4>Yeah, just a great anti septic for.

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<v Speaker 2>It is it is historically used as well as today.

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<v Speaker 4>As well as today. Yep. Yeah, you can find the

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<v Speaker 4>full recipe for that on our website. This podcast we

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<v Speaker 4>kill You dot com and all of our socials This

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<v Speaker 4>podcast will kill you most places.

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<v Speaker 1>Just search this podcast kill you and you'll find us.

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<v Speaker 1>You'll find us and if you if that searching lands

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<v Speaker 1>you on our website. Other things that you can find include.

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<v Speaker 3>Bookshop dot org, affiliate page, Goodreads list, links to music

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<v Speaker 3>by Bloodmobile, a Furtian account, form of contact us form,

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<v Speaker 3>links to merch Patreon, transcripts, et cetera.

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<v Speaker 4>There's a lot there, isn't there a lot there? Yeah?

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<v Speaker 4>This podcast will kill You dot com. Thank you for

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<v Speaker 4>rating and reviewing and subscribing to this podcast on your

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<v Speaker 4>favorite podcasterer and or on YouTube hello or on YouTube

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<v Speaker 4>on YouTube satchers Yep. The end? Shall we have got

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<v Speaker 4>a lot to cover? Yeah, let's get into it.

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<v Speaker 5>Yeah, Okay.

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<v Speaker 4>For today's episode, I wanted to take us through how

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<v Speaker 4>exactly we classify burns in medicine and what this classification

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<v Speaker 4>means for how our body responds to a burn injury.

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<v Speaker 4>Because although a burn is a type of trauma to

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<v Speaker 4>our skin. And there's a lot of other traumas that

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<v Speaker 4>we could get to our skin right scrapes, cuts, et cetera.

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<v Speaker 4>Our body's response to burn injuries is actually fairly unique.

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<v Speaker 4>Even though it is still the same inflammatory response, it

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<v Speaker 4>is also unique. It's kind of interesting, huh. Okay, And

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<v Speaker 4>what I really think and what I took away from

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<v Speaker 4>digging really deep into this is that what burns really

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<v Speaker 4>show us is just how incredible and how important of

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<v Speaker 4>an organ our skin is, true, and how severe damage

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<v Speaker 4>to that skin has life threatening consequences and long lasting consequences.

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<v Speaker 4>So I'm gonna walk us through the types of burns

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<v Speaker 4>that we can see, burn severity and how we actually

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<v Speaker 4>determine severe versus minor or major versus minor burns, and

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<v Speaker 4>what is happening to our whole entire body as a

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<v Speaker 4>result of a burn injury, and then save the like,

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<v Speaker 4>what do we do about these burns for next week's episode?

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<v Speaker 2>Okay, sounds good.

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<v Speaker 4>So a lot of different things can actually cause the

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<v Speaker 4>type of damage that we would refer to as a burn,

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<v Speaker 4>and the source of a burn really does matter a

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<v Speaker 4>lot because the pattern of injury that you see can

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<v Speaker 4>be really different depending on the source of that burn. So,

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<v Speaker 4>as an example, electrical burns, which we've talked about in

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<v Speaker 4>our Lightning episode, we talked a lot about electric burns.

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<v Speaker 4>They can cause really severe deep damage to our internal

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<v Speaker 4>structures with very minimal visible surface injury. But those are

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<v Speaker 4>still going to be burn injuries, but deeper. A burn

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<v Speaker 4>from a chemical, like say a strong acid, might cause

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<v Speaker 4>coagulation necrosis, so your blood vessels are all clotting and

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<v Speaker 4>all your blood is clotting, while a burn from an

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<v Speaker 4>alkaline chemical might actually liquefy your tissues completely. WHOA, Yeah,

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<v Speaker 4>So burns from chemicals are going to act a little

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<v Speaker 4>bit differently, and they might differ in how we need

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<v Speaker 4>to treat them. You can think of frostbite as a

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<v Speaker 4>type of cold burn, and those need to be rewarmed

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<v Speaker 4>and watched. See our two episodes on cold and cold injuries.

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<v Speaker 4>Hypotheth that what we call them, I think, So, yeah,

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<v Speaker 4>I was like, what did we call this? Whereas a

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<v Speaker 4>heat burn is going to be different, and so most

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<v Speaker 4>of what I'm going to talk about, though it pro

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<v Speaker 4>probaly applies to most all burns. They're really I'm talking

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<v Speaker 4>mostly about thermal burns. So burns as a result of

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<v Speaker 4>heat injury.

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<v Speaker 2>Did you mention radiation burns?

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<v Speaker 4>I didn't, But those are yet another type of ok

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<v Speaker 4>that might be more like more similar to maybe a

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<v Speaker 4>chemical burn, or or somewhere in between a little bit different. Okay, Yeah,

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<v Speaker 4>So yeah, there's a lot of different kinds of burns,

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<v Speaker 4>but so I'm focusing mostly on thermal burns. These are

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<v Speaker 4>the most common types of burns worldwide. And these can

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<v Speaker 4>be flame burns so from a fire, as well as

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<v Speaker 4>skaled type burns, so think hot liquid and those sorts

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<v Speaker 4>of things, and those are the two most common types

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<v Speaker 4>of burns worldwide. Once we know what caused the burn,

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<v Speaker 4>then the next thing that we need to know is

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<v Speaker 4>the severity of that burn. And the severity is a

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<v Speaker 4>combination of the body surface area that's affected, so how

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<v Speaker 4>much of your body got burned and the depth of

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<v Speaker 4>that burn. And then of course we also need to

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<v Speaker 4>look for whether there was any additional injury or traumas,

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<v Speaker 4>especially in the case of something like a flame burn,

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<v Speaker 4>you might have inhalational injuries or a chemical burn, you

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<v Speaker 4>might have other toxin exposures. You could even have like

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<v Speaker 4>blunt trauma injuries, right, depending on how the burn was sustained.

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<v Speaker 4>And then there's patient factors that might make someone more

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<v Speaker 4>susceptible to severe outcomes from a less severe burn, like

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<v Speaker 4>say a very young child or a very old person,

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<v Speaker 4>et cetera.

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<v Speaker 2>Underlying health issues.

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<v Speaker 4>So exactly diabetes that might interfere with wound healing things

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<v Speaker 4>like that. So let's go through how we kind of

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<v Speaker 4>get to the severity we already mentioned. And a lot

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<v Speaker 4>of us have heard of the idea of a first, second,

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<v Speaker 4>and third degree burn, and that is like classically how

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<v Speaker 4>we classify burns. And I say that we don't quite

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<v Speaker 4>use it as much today because we now get a

0:13:51.640 --> 0:13:54.360
<v Speaker 4>little bit more specific based on the thickness or the

0:13:54.400 --> 0:13:58.400
<v Speaker 4>depth of the burn in our skin, but colloquially we

0:13:58.480 --> 0:14:00.640
<v Speaker 4>still use for second, third degree. So we'll just go

0:14:00.679 --> 0:14:03.800
<v Speaker 4>a little bit more detailed, Okay, And first I want

0:14:03.840 --> 0:14:05.960
<v Speaker 4>to take us through our skin. And we've talked about

0:14:05.960 --> 0:14:08.760
<v Speaker 4>our skin on a number of episodes before, including like

0:14:08.840 --> 0:14:13.760
<v Speaker 4>our retinoid's episodes. Yes, but our skin is an incredibly

0:14:13.800 --> 0:14:17.840
<v Speaker 4>important organ, and it's a layered organ, the largest organ

0:14:17.920 --> 0:14:20.320
<v Speaker 4>in our whole entire body, and it's made up of

0:14:20.400 --> 0:14:23.320
<v Speaker 4>several different layers. The top layer, the outside what you're

0:14:23.360 --> 0:14:26.560
<v Speaker 4>touching and what you see, is called the epidermis. And

0:14:26.600 --> 0:14:31.280
<v Speaker 4>this is very very thin layer, and it differs in

0:14:31.360 --> 0:14:33.680
<v Speaker 4>thickness depending on where on your body. So it's a

0:14:33.680 --> 0:14:36.040
<v Speaker 4>lot thicker in places like the soles of our feet

0:14:36.240 --> 0:14:39.400
<v Speaker 4>and our back, and it's a lot thinner in places

0:14:39.400 --> 0:14:41.720
<v Speaker 4>like say, your eyes or you know, the backs of

0:14:41.760 --> 0:14:45.680
<v Speaker 4>your hands or things like that. Underneath the epidermis is

0:14:45.760 --> 0:14:49.200
<v Speaker 4>the dermis, and this is the layer that has a

0:14:49.240 --> 0:14:52.080
<v Speaker 4>lot of structure to it. It's a little bit thicker still,

0:14:52.120 --> 0:14:54.720
<v Speaker 4>only on the order of millimeters, but the dermis is

0:14:54.760 --> 0:14:57.440
<v Speaker 4>underneath that. And then underneath the dermis is a layer

0:14:57.520 --> 0:15:00.800
<v Speaker 4>of subcutaneous tissue, so this is like fa and things

0:15:00.840 --> 0:15:03.040
<v Speaker 4>like that. And then below that is when we get

0:15:03.040 --> 0:15:07.920
<v Speaker 4>to muscles and bones. Okay, So the degree of a

0:15:07.920 --> 0:15:12.480
<v Speaker 4>burn depends on how far through that skin layers. Through

0:15:12.480 --> 0:15:15.920
<v Speaker 4>those layers of skin, we actually get. A superficial burn,

0:15:16.000 --> 0:15:18.680
<v Speaker 4>or a first degree burn, is one that burns only

0:15:18.920 --> 0:15:23.120
<v Speaker 4>the uppermost layer, the epidermis. This you can think of

0:15:23.200 --> 0:15:28.280
<v Speaker 4>as a bad sunburn, right, okay, blister, no, not a

0:15:28.280 --> 0:15:30.800
<v Speaker 4>blister type of thing. Okay, So a bad sunburn. Your

0:15:30.800 --> 0:15:35.400
<v Speaker 4>skin is red, angry, and it's painful, but beyond that,

0:15:35.720 --> 0:15:39.520
<v Speaker 4>it's generally does not blister, okay, And it does not

0:15:40.120 --> 0:15:43.840
<v Speaker 4>need any kind of specialized treatment, and you're not going

0:15:43.880 --> 0:15:47.160
<v Speaker 4>to get a scar or any residual defects or anything.

0:15:47.640 --> 0:15:50.720
<v Speaker 4>These type of superficial or first degree burns generally heal

0:15:50.760 --> 0:15:53.880
<v Speaker 4>within a week or so, but no blistering. That is

0:15:53.880 --> 0:15:57.000
<v Speaker 4>when we get into second degree burns, okay. And what

0:15:57.200 --> 0:15:59.520
<v Speaker 4>used to be just lumped as second degree burns is

0:15:59.560 --> 0:16:04.040
<v Speaker 4>now into two different types. So the first is a

0:16:04.080 --> 0:16:07.920
<v Speaker 4>superficial partial thickness burn. This is the one erin that

0:16:07.960 --> 0:16:10.920
<v Speaker 4>will blister, okay. And so this is a burn that

0:16:10.960 --> 0:16:14.800
<v Speaker 4>burns completely through the epidermis and then into the first

0:16:14.840 --> 0:16:18.200
<v Speaker 4>part of the dermis, but does not go like deeply

0:16:18.360 --> 0:16:21.440
<v Speaker 4>into the dermis, okay. And so this is something that

0:16:21.480 --> 0:16:24.360
<v Speaker 4>you might get if you burn yourself on a pan

0:16:24.600 --> 0:16:28.280
<v Speaker 4>or the oven or like really hot you know, liquid

0:16:28.280 --> 0:16:31.320
<v Speaker 4>that spills on you or something. These burns are very

0:16:31.440 --> 0:16:35.400
<v Speaker 4>very painful. They might be red, they might be blistered,

0:16:35.480 --> 0:16:38.640
<v Speaker 4>they might be very wet and kind of weep and

0:16:39.120 --> 0:16:42.680
<v Speaker 4>you have to take care of these wounds. But you're

0:16:42.720 --> 0:16:46.280
<v Speaker 4>not going to need surgery to fix these wounds. Ye,

0:16:46.480 --> 0:16:49.760
<v Speaker 4>because the layer of the dermis has not been completely

0:16:49.760 --> 0:16:52.000
<v Speaker 4>burned through, and so your skin is going to be

0:16:52.040 --> 0:16:54.720
<v Speaker 4>able to it's called re epithelialize. It's going to be

0:16:54.760 --> 0:16:57.400
<v Speaker 4>able to make new skin to cover up this wound

0:16:57.680 --> 0:17:01.560
<v Speaker 4>without a lot of additional help. Most of the time,

0:17:01.600 --> 0:17:04.160
<v Speaker 4>you're not going to get a scar from these types

0:17:04.200 --> 0:17:07.399
<v Speaker 4>of burns. If you do, it might just be pigmentation

0:17:07.600 --> 0:17:11.320
<v Speaker 4>changes because of losses of like the melanocytes that are

0:17:11.359 --> 0:17:16.320
<v Speaker 4>in more of the epidermal layer. Okay, okay. Next is

0:17:16.480 --> 0:17:19.800
<v Speaker 4>again within this considered second degree burn is called a

0:17:19.920 --> 0:17:25.400
<v Speaker 4>deep partial thickness burn, and the deep partial thickness burns

0:17:25.440 --> 0:17:27.960
<v Speaker 4>actually tend to hurt a little bit less than the

0:17:28.000 --> 0:17:31.639
<v Speaker 4>first two, and that's because they burn deeply enough that

0:17:31.680 --> 0:17:37.200
<v Speaker 4>they're actually destroying our pain receptors in our skin. These

0:17:37.240 --> 0:17:40.560
<v Speaker 4>burns tend to be a lot drier than a superficial

0:17:40.600 --> 0:17:44.320
<v Speaker 4>partial thickness burn, so you don't necessarily have blisters, or

0:17:44.320 --> 0:17:46.960
<v Speaker 4>if you do, they're just not quite as wet as

0:17:46.960 --> 0:17:51.639
<v Speaker 4>a superficial burn. They often look either very dark pink

0:17:51.960 --> 0:17:55.520
<v Speaker 4>or sometimes almost white, where they just look like it

0:17:55.560 --> 0:17:57.480
<v Speaker 4>doesn't really look like there's anything there. It's just like

0:17:57.520 --> 0:18:01.959
<v Speaker 4>completely white, regardless of your skin color. And they're almost

0:18:02.000 --> 0:18:05.960
<v Speaker 4>kind of pearly looking, rather like or like waxy looking

0:18:06.000 --> 0:18:11.000
<v Speaker 4>a little bit. These generally do need surgery very often.

0:18:11.160 --> 0:18:13.720
<v Speaker 4>These are deep enough that the skin is not going

0:18:13.720 --> 0:18:16.080
<v Speaker 4>to be able to completely heal over this without some

0:18:16.240 --> 0:18:18.639
<v Speaker 4>kind of surgical intervention, and that means that they're at

0:18:18.720 --> 0:18:22.800
<v Speaker 4>much higher risk of some kind of scar formation. There's

0:18:22.840 --> 0:18:26.640
<v Speaker 4>not a huge leap then, from a deep partial thickness

0:18:26.760 --> 0:18:29.760
<v Speaker 4>to a full thickness burn or a third degree burn,

0:18:30.440 --> 0:18:33.639
<v Speaker 4>and this is one that extends completely through the dermis,

0:18:33.680 --> 0:18:37.399
<v Speaker 4>so the epidermal layer and the dermis are completely burned

0:18:37.440 --> 0:18:42.199
<v Speaker 4>through all the way down into that subcutaneous tissue. In

0:18:42.280 --> 0:18:44.840
<v Speaker 4>some cases it a burn can extend all the way

0:18:44.880 --> 0:18:46.960
<v Speaker 4>down into our deeper tissues, which is sometimes called a

0:18:47.000 --> 0:18:49.560
<v Speaker 4>fourth degree burn, or sometimes it's just lumped under this

0:18:49.600 --> 0:18:51.960
<v Speaker 4>third degree, and that means that there's damage to the

0:18:52.040 --> 0:18:54.440
<v Speaker 4>muscles or the bones, depending on how deep it goes.

0:18:55.720 --> 0:18:59.720
<v Speaker 4>These full thickness burns are not painful because all of

0:18:59.760 --> 0:19:03.960
<v Speaker 4>our nerve endings have been destroyed. And I asked risk

0:19:04.040 --> 0:19:08.560
<v Speaker 4>that erin, Yeah, because that just means that at the

0:19:08.600 --> 0:19:12.760
<v Speaker 4>time of the injury, that specific area that sustained a

0:19:12.800 --> 0:19:15.480
<v Speaker 4>full thickness burn, if you touch it, you will not

0:19:15.600 --> 0:19:18.080
<v Speaker 4>feel that the way that if you touch a burn blister,

0:19:18.160 --> 0:19:21.159
<v Speaker 4>it really hurts. But that doesn't mean that they're not

0:19:21.240 --> 0:19:23.560
<v Speaker 4>painful in the long run, or.

0:19:24.000 --> 0:19:28.639
<v Speaker 1>That you only have a third degree burn and that

0:19:28.720 --> 0:19:31.439
<v Speaker 1>other parts of your body are not experiencing first and

0:19:31.520 --> 0:19:32.159
<v Speaker 1>second degrees.

0:19:32.280 --> 0:19:36.639
<v Speaker 4>Yeah, exactly, exactly, very very often, almost always, if someone

0:19:36.720 --> 0:19:40.840
<v Speaker 4>has severe burns, not every part of the burn is

0:19:40.960 --> 0:19:43.960
<v Speaker 4>the same degree. Right, You have a mix of burns

0:19:44.000 --> 0:19:47.720
<v Speaker 4>of varying degrees or varying thicknesses on different parts of

0:19:47.720 --> 0:19:49.919
<v Speaker 4>that burn, which means, yes, things are likely going to

0:19:49.960 --> 0:19:52.359
<v Speaker 4>be very painful, even if parts of those burns have

0:19:52.680 --> 0:19:54.760
<v Speaker 4>completely destroyed the nerve endings and everything.

0:19:55.240 --> 0:19:58.359
<v Speaker 1>Okay, So I have a question about like surface area

0:19:58.480 --> 0:20:02.320
<v Speaker 1>and degrees. Yeah, because it's a big like we just

0:20:02.359 --> 0:20:06.520
<v Speaker 1>talked about, there's a mixture of, yes, different degrees or

0:20:06.560 --> 0:20:09.600
<v Speaker 1>severities of the burn in different parts of your body.

0:20:09.640 --> 0:20:12.200
<v Speaker 1>So how is that calculated? How does that get incorporated

0:20:12.200 --> 0:20:13.760
<v Speaker 1>into total body surface area?

0:20:13.920 --> 0:20:16.080
<v Speaker 4>That's a great question. So total body surface area is

0:20:16.119 --> 0:20:18.040
<v Speaker 4>the next thing that we have to look at. So

0:20:18.119 --> 0:20:20.600
<v Speaker 4>once we know, and I say it as if these

0:20:20.600 --> 0:20:23.280
<v Speaker 4>are separate things, they're really not. Like we're looking at

0:20:23.320 --> 0:20:25.080
<v Speaker 4>all of this at the same time. If someone comes

0:20:25.119 --> 0:20:28.200
<v Speaker 4>into a hospital with a burn, but total body surface

0:20:28.240 --> 0:20:31.680
<v Speaker 4>area is how much of your body surface is covered

0:20:31.680 --> 0:20:34.520
<v Speaker 4>by this burn, regardless of the degree, So you don't

0:20:34.560 --> 0:20:36.760
<v Speaker 4>need to separate it by oh, you know this much

0:20:36.800 --> 0:20:39.400
<v Speaker 4>surface area was a first degree versus second versus third.

0:20:39.680 --> 0:20:41.880
<v Speaker 4>Here we're just looking at how much of your skin

0:20:41.960 --> 0:20:46.160
<v Speaker 4>got burned. And this is actually the most important part

0:20:46.560 --> 0:20:51.479
<v Speaker 4>in looking at mortality is surface area. So how we

0:20:51.520 --> 0:20:54.879
<v Speaker 4>classify something as a so called minor burn, This is

0:20:54.920 --> 0:20:57.960
<v Speaker 4>actually a lot more. I won't even say contentious in

0:20:58.000 --> 0:20:59.720
<v Speaker 4>the literature because I don't think anyone's fighting over it.

0:20:59.760 --> 0:21:03.480
<v Speaker 4>But it really depends on the situation whether something is

0:21:03.520 --> 0:21:08.040
<v Speaker 4>considered a severe or a minor burn. In general, most

0:21:08.080 --> 0:21:11.760
<v Speaker 4>people don't require hospitalization for burns that cover less than

0:21:11.760 --> 0:21:14.320
<v Speaker 4>ten percent of their body surface. But that's a huge

0:21:14.359 --> 0:21:17.399
<v Speaker 4>generalization because a burn on the face, a burn on

0:21:17.400 --> 0:21:20.280
<v Speaker 4>the groin, a burn on the hands, even if it's

0:21:20.320 --> 0:21:24.399
<v Speaker 4>significantly less than ten percent, might still require hospitalization as

0:21:24.480 --> 0:21:26.919
<v Speaker 4>well as depending on the thickness or the degree of

0:21:26.920 --> 0:21:27.399
<v Speaker 4>that burn.

0:21:27.960 --> 0:21:30.240
<v Speaker 1>Or other injuries sustained or types of exact type of

0:21:30.320 --> 0:21:31.160
<v Speaker 1>burn that it is.

0:21:31.200 --> 0:21:35.440
<v Speaker 4>Yeah, exactly, So that is really an over generalization. Most

0:21:35.480 --> 0:21:37.960
<v Speaker 4>of the time, if we're thinking about what is going

0:21:38.000 --> 0:21:42.760
<v Speaker 4>to cause more likely to cause systemic symptoms, then we're

0:21:42.800 --> 0:21:45.480
<v Speaker 4>looking at burns that are maybe more than fifteen or

0:21:45.520 --> 0:21:49.800
<v Speaker 4>twenty percent of your body surface area, depending on the

0:21:49.840 --> 0:21:52.520
<v Speaker 4>person and their age and like how big they are, right,

0:21:52.520 --> 0:21:55.080
<v Speaker 4>Like a kid might have a less body surface area

0:21:55.119 --> 0:21:58.119
<v Speaker 4>to cause severe effects. But all of that is really

0:21:58.200 --> 0:22:01.200
<v Speaker 4>like it so depends on the person, right, So there's

0:22:01.240 --> 0:22:03.240
<v Speaker 4>not like a clear cut definition of like this is

0:22:03.520 --> 0:22:06.359
<v Speaker 4>a major burn versus a minor burn, or a severe

0:22:06.400 --> 0:22:09.919
<v Speaker 4>burn versus a non severe burn. But calculating that body

0:22:09.920 --> 0:22:13.960
<v Speaker 4>surface area is a really important part of the care

0:22:14.119 --> 0:22:17.479
<v Speaker 4>of a person and understanding how severe their outcomes are

0:22:17.480 --> 0:22:19.479
<v Speaker 4>going to be. And the way that we do that

0:22:19.880 --> 0:22:21.760
<v Speaker 4>is there's a couple different ways. There's a fast and

0:22:21.800 --> 0:22:24.560
<v Speaker 4>ready way kind of that is called the rule of nines,

0:22:25.359 --> 0:22:27.520
<v Speaker 4>and that is that we just split up an adult

0:22:27.640 --> 0:22:31.320
<v Speaker 4>body area into areas that are about nine percent. So

0:22:31.359 --> 0:22:33.760
<v Speaker 4>our head is about nine percent of our body surface.

0:22:34.440 --> 0:22:36.760
<v Speaker 4>Our chest, the front side of our chest, and the

0:22:36.760 --> 0:22:39.439
<v Speaker 4>front side of our abdomen are each nine percent, and

0:22:39.480 --> 0:22:42.120
<v Speaker 4>same thing with the back, so that's like eighteen and eighteen,

0:22:42.920 --> 0:22:44.960
<v Speaker 4>and then the front of our legs are nine percent,

0:22:45.000 --> 0:22:46.560
<v Speaker 4>the back of our legs are nine percent, on our

0:22:46.560 --> 0:22:48.760
<v Speaker 4>two arms put together are nine percent, and then an

0:22:48.800 --> 0:22:50.400
<v Speaker 4>extra one percent for the genitals.

0:22:50.760 --> 0:22:51.119
<v Speaker 2>Okay.

0:22:51.720 --> 0:22:54.399
<v Speaker 4>The other way that you can do it though, because

0:22:54.400 --> 0:22:58.480
<v Speaker 4>that calculation does not hold true for children because children

0:22:58.560 --> 0:23:03.080
<v Speaker 4>their head is a magnificantly larger body surface than especially

0:23:03.160 --> 0:23:06.399
<v Speaker 4>for babies, So there's different calculations that we use for

0:23:06.560 --> 0:23:10.800
<v Speaker 4>children and babies. But you also could use a person's hand,

0:23:10.960 --> 0:23:14.720
<v Speaker 4>so not my hand to calculate your burn area, but

0:23:14.880 --> 0:23:19.320
<v Speaker 4>your hand to calculated mind to calculate mine our palm.

0:23:19.560 --> 0:23:22.240
<v Speaker 4>So the entire surface of our hand, including our fingers

0:23:22.280 --> 0:23:25.639
<v Speaker 4>on our palm is about one percent. Okay, that's considered

0:23:25.640 --> 0:23:27.600
<v Speaker 4>about one percent total, so you can use that to

0:23:27.680 --> 0:23:31.000
<v Speaker 4>kind of estimate if it's less than nine percent or something.

0:23:31.000 --> 0:23:33.840
<v Speaker 4>You're trying to get a rough estimate. So that's how

0:23:33.880 --> 0:23:39.080
<v Speaker 4>we sort of calculate and estimate how severe a burn is.

0:23:40.160 --> 0:23:42.520
<v Speaker 4>And of course, like I said at the very top,

0:23:42.640 --> 0:23:47.080
<v Speaker 4>our skin is the largest organ in our body, so

0:23:47.359 --> 0:23:52.880
<v Speaker 4>damage even to a small portion of that organ has

0:23:52.920 --> 0:23:58.159
<v Speaker 4>the potential to cause a whole body response, and the

0:23:58.280 --> 0:24:02.199
<v Speaker 4>response that we see really depends on the depth of

0:24:02.240 --> 0:24:06.080
<v Speaker 4>that burn, the surface area of that burn, and the

0:24:06.119 --> 0:24:09.879
<v Speaker 4>person who sustained that burn and what their underlying conditions is.

0:24:10.920 --> 0:24:13.480
<v Speaker 4>But we can kind of understand how this process is

0:24:13.520 --> 0:24:17.360
<v Speaker 4>going to go if we understand our basic inflammatory response

0:24:17.400 --> 0:24:20.200
<v Speaker 4>and how our body responds to wounds in our skin,

0:24:21.040 --> 0:24:23.080
<v Speaker 4>which we've talked about on previous episodes. I think on

0:24:23.119 --> 0:24:27.639
<v Speaker 4>our Maggot's episode, we talked about this inflammatory response because

0:24:27.640 --> 0:24:29.960
<v Speaker 4>anytime that our skin is wounded from a burn or

0:24:30.040 --> 0:24:33.360
<v Speaker 4>a scrape or a scratch, our body follows a very

0:24:33.359 --> 0:24:36.399
<v Speaker 4>predictable series of responses to try and repair that wound.

0:24:37.000 --> 0:24:39.840
<v Speaker 4>The very first thing is hemostasis right. We have to

0:24:39.880 --> 0:24:42.639
<v Speaker 4>stop the bleeding because most of the time wounds bleed

0:24:43.240 --> 0:24:45.840
<v Speaker 4>very often they don't in the case of burns, and

0:24:45.880 --> 0:24:49.200
<v Speaker 4>we'll get to why that is. But the second thing

0:24:49.480 --> 0:24:52.959
<v Speaker 4>that's going to happen is inflammation, and this is to

0:24:53.200 --> 0:24:56.879
<v Speaker 4>bring helpers to the area in order to start the

0:24:56.960 --> 0:25:01.000
<v Speaker 4>repair process. The third step is prolifer. We need to

0:25:01.040 --> 0:25:04.040
<v Speaker 4>start making new cells to fill in the gaps that

0:25:04.080 --> 0:25:07.879
<v Speaker 4>are left by this wound, and finally we have maturation

0:25:08.040 --> 0:25:12.440
<v Speaker 4>or remodeling. That's the finishing up that is really scar formation,

0:25:12.600 --> 0:25:16.880
<v Speaker 4>because our skin pretty much always heals by scarring, so

0:25:17.040 --> 0:25:19.960
<v Speaker 4>in the event of a burn, our body is going

0:25:20.000 --> 0:25:26.240
<v Speaker 4>to attempt to heal by this similar process. However, because

0:25:26.280 --> 0:25:28.960
<v Speaker 4>of some specific things that happen, especially in the case

0:25:29.000 --> 0:25:32.840
<v Speaker 4>of a thermal burn, so a heat related burn, as

0:25:32.880 --> 0:25:36.800
<v Speaker 4>well as the potential for a very large portion of

0:25:36.840 --> 0:25:40.720
<v Speaker 4>our skin to be affected, the end result is often

0:25:40.760 --> 0:25:45.040
<v Speaker 4>a pretty disregulated body response that can be really severe.

0:25:45.640 --> 0:25:48.960
<v Speaker 4>So unlike say a cut or a scrape that just

0:25:49.119 --> 0:25:54.159
<v Speaker 4>has damage wherever that scrape actually happened, a burned wound

0:25:54.320 --> 0:25:58.920
<v Speaker 4>actually has several different zones of injury. In the very

0:25:59.200 --> 0:26:02.480
<v Speaker 4>center or like where the burn was actually sustained is

0:26:02.520 --> 0:26:05.760
<v Speaker 4>what's called a zone of coagulation. You can think of

0:26:05.800 --> 0:26:08.720
<v Speaker 4>this as not necessarily the deepest part of the burn,

0:26:08.760 --> 0:26:12.040
<v Speaker 4>but like the part that actually had contact with the

0:26:12.080 --> 0:26:14.400
<v Speaker 4>hot liquid or the flame or whatever it was that

0:26:14.440 --> 0:26:18.720
<v Speaker 4>caused the injury, and in that area the tissue is dead,

0:26:19.680 --> 0:26:23.000
<v Speaker 4>the blood cells are coagulated, so there's no bleeding in

0:26:23.040 --> 0:26:26.800
<v Speaker 4>that area because of the strong heat that was applied

0:26:28.119 --> 0:26:35.240
<v Speaker 4>and that tissue in that area cannot be completely salvaged. Okay, Okay.

0:26:35.840 --> 0:26:40.320
<v Speaker 4>Immediately around this there is a zone of stasis, and

0:26:40.400 --> 0:26:44.960
<v Speaker 4>in this area there is a lot of inflammation. So

0:26:45.040 --> 0:26:49.240
<v Speaker 4>our body is trying to respond to that central area.

0:26:49.400 --> 0:26:53.440
<v Speaker 4>It knows that there's something wrong here, but there's very

0:26:53.520 --> 0:26:56.840
<v Speaker 4>low levels of blood flow. There's a lot less profusion

0:26:57.040 --> 0:27:00.040
<v Speaker 4>in this zone because of damage that was sustained and

0:27:00.240 --> 0:27:03.000
<v Speaker 4>our body's response of kind of clamping down to try

0:27:03.040 --> 0:27:07.160
<v Speaker 4>and protect that area, which has the effect that if

0:27:07.160 --> 0:27:09.679
<v Speaker 4>that area is not addressed, then the damage from the

0:27:09.680 --> 0:27:13.080
<v Speaker 4>burn can actually extend out over the next twenty four

0:27:13.080 --> 0:27:13.959
<v Speaker 4>to forty eight hours.

0:27:14.440 --> 0:27:15.879
<v Speaker 2>How can it do that.

0:27:16.400 --> 0:27:19.760
<v Speaker 4>Because that area, that zone of stasis, is not getting

0:27:19.880 --> 0:27:22.760
<v Speaker 4>enough blood flow. If that blood flow is not restored

0:27:22.840 --> 0:27:25.760
<v Speaker 4>to that area, then that area is also going to

0:27:25.800 --> 0:27:28.639
<v Speaker 4>die because of a lack of blood flow. Okay, that

0:27:28.760 --> 0:27:29.760
<v Speaker 4>kind of makes sense, I think, so.

0:27:30.000 --> 0:27:30.760
<v Speaker 2>Yeah.

0:27:31.119 --> 0:27:34.000
<v Speaker 4>And then outside of that zone is called the zone

0:27:34.000 --> 0:27:37.320
<v Speaker 4>of hyperaemia. And this is non damage tissue where perfusion

0:27:37.480 --> 0:27:40.800
<v Speaker 4>hasn't been affected, and this is all like viable tissue essentially.

0:27:41.840 --> 0:27:44.879
<v Speaker 4>So in the first forty eight hours, it's important to

0:27:44.880 --> 0:27:49.240
<v Speaker 4>be able to find those areas and see how much

0:27:49.280 --> 0:27:52.520
<v Speaker 4>tissue can be salvaged, especially and I'm talking really in

0:27:52.560 --> 0:27:56.040
<v Speaker 4>the case of deep partial thickness, so like those more

0:27:56.080 --> 0:28:01.160
<v Speaker 4>severe second degree burns or third degree or full thickness burns, right, Okay,

0:28:01.480 --> 0:28:04.640
<v Speaker 4>this isn't necessarily happening in a superficial burn where it's

0:28:04.760 --> 0:28:06.359
<v Speaker 4>just the epidermis.

0:28:06.520 --> 0:28:09.080
<v Speaker 1>Okay, So just so I want to go over this,

0:28:09.160 --> 0:28:11.679
<v Speaker 1>so I think make sure I understand this. So you

0:28:12.119 --> 0:28:14.600
<v Speaker 1>experience a second degree burn, Let's say it's like on

0:28:14.640 --> 0:28:18.080
<v Speaker 1>your leg, there's the area that is like the most

0:28:18.119 --> 0:28:23.119
<v Speaker 1>severe part that things are bad. The burn has happened

0:28:23.119 --> 0:28:28.119
<v Speaker 1>directly there, and then surrounding that area there's sort of

0:28:28.119 --> 0:28:31.280
<v Speaker 1>the area that has also been kind of affected but

0:28:31.400 --> 0:28:36.480
<v Speaker 1>not directly by the thermal injury. But it's that area

0:28:36.560 --> 0:28:41.120
<v Speaker 1>that needs to be like looked after because it's at

0:28:41.200 --> 0:28:43.440
<v Speaker 1>risk of dying. And so that's where a lot of

0:28:43.480 --> 0:28:47.960
<v Speaker 1>the inflammation comes into there. Yes, Yes, not necessarily the

0:28:48.000 --> 0:28:51.120
<v Speaker 1>central point of the burn itself, because there's nothing left.

0:28:51.760 --> 0:28:54.040
<v Speaker 1>There's no more tissue left to go to that is

0:28:54.080 --> 0:28:58.720
<v Speaker 1>alive and receptive, right, right to do the remodeling first, exactly,

0:28:58.920 --> 0:29:02.040
<v Speaker 1>So yes, in that tissue that is completely dead, our

0:29:02.080 --> 0:29:04.000
<v Speaker 1>inflammatory response can't kick in there.

0:29:04.040 --> 0:29:05.800
<v Speaker 4>We don't have blood flow there, there's.

0:29:05.720 --> 0:29:09.240
<v Speaker 1>No blood flow, there's no opportunity for anything. So then okay,

0:29:09.320 --> 0:29:10.440
<v Speaker 1>everything has to be restored.

0:29:10.760 --> 0:29:12.760
<v Speaker 4>Everything has to be restored. So that's the first challenge

0:29:12.800 --> 0:29:16.600
<v Speaker 4>is identifying those areas that need restoration that we need

0:29:16.640 --> 0:29:19.640
<v Speaker 4>to do something otherwise that repair process is not going

0:29:19.680 --> 0:29:22.520
<v Speaker 4>to be able to start. That's the first challenge. The

0:29:22.600 --> 0:29:26.080
<v Speaker 4>second challenge is that all of the surrounding tissue will

0:29:26.200 --> 0:29:30.200
<v Speaker 4>have a lot of inflammation right because our body knows

0:29:30.240 --> 0:29:32.520
<v Speaker 4>that something is going on and they're trying really hard

0:29:32.720 --> 0:29:35.080
<v Speaker 4>to send in all the troops. That means in the

0:29:35.160 --> 0:29:39.120
<v Speaker 4>surrounding areas we have a lot of vasodilation. That means

0:29:39.160 --> 0:29:41.680
<v Speaker 4>our blood vessels are getting larger, and that's to accommodate

0:29:41.720 --> 0:29:46.360
<v Speaker 4>more flow. We see an increase in vascular permeability, so

0:29:46.400 --> 0:29:48.920
<v Speaker 4>that means that our blood vessels are more leaky, and

0:29:48.960 --> 0:29:51.960
<v Speaker 4>that is to allow all of the plasma that has

0:29:52.000 --> 0:29:54.800
<v Speaker 4>our white blood cells and the inflammatory markers and the

0:29:54.840 --> 0:29:57.960
<v Speaker 4>cytokines and all these things into the area to try

0:29:57.960 --> 0:30:01.760
<v Speaker 4>and help. But unfortunate only what that ends up resulting

0:30:01.800 --> 0:30:04.680
<v Speaker 4>in is a lot of edema. So a lot of

0:30:04.880 --> 0:30:08.280
<v Speaker 4>fluid in the area because the degree of inflammatory signals

0:30:08.320 --> 0:30:11.320
<v Speaker 4>is so high, and this can be in and of

0:30:11.360 --> 0:30:15.320
<v Speaker 4>itself very dangerous, especially in the event of like a

0:30:15.440 --> 0:30:18.920
<v Speaker 4>circumferential burn. So think like a burn that goes around

0:30:19.080 --> 0:30:23.520
<v Speaker 4>your entire arm, for example. Basically the fluid has nowhere

0:30:23.560 --> 0:30:26.200
<v Speaker 4>to go and so that's going to increase pressure in

0:30:26.240 --> 0:30:28.760
<v Speaker 4>that area. Does that make sense, yes?

0:30:29.080 --> 0:30:33.240
<v Speaker 1>How how does blood pressure overall play, Like what happens

0:30:33.240 --> 0:30:34.080
<v Speaker 1>to your blood pressure?

0:30:34.280 --> 0:30:37.760
<v Speaker 4>Yeah? So the path of physiology of burns, severe burns

0:30:37.800 --> 0:30:40.840
<v Speaker 4>especially is divided into two phases. The first phase is

0:30:40.880 --> 0:30:43.680
<v Speaker 4>in these first twenty four to seventy two hours, okay,

0:30:43.720 --> 0:30:46.760
<v Speaker 4>and that's called the hypodynamic phase, and that is when

0:30:46.880 --> 0:30:49.960
<v Speaker 4>all this inflammation is happening. Our bodies kicking into high gear.

0:30:50.360 --> 0:30:54.400
<v Speaker 4>Inflammatory markers are going everywhere, Vascular permeability is up, so

0:30:54.440 --> 0:30:57.000
<v Speaker 4>we are at very high risk of going into shock.

0:30:57.640 --> 0:31:00.240
<v Speaker 4>And shock, as we learned in our sepsis episode, means

0:31:00.280 --> 0:31:04.000
<v Speaker 4>a drop in your blood pressure enough so that all

0:31:04.040 --> 0:31:09.080
<v Speaker 4>of your other organs are not getting enough blood. So

0:31:09.280 --> 0:31:13.720
<v Speaker 4>this is incredibly dangerous. It can result in multi organ failure,

0:31:14.320 --> 0:31:17.440
<v Speaker 4>kidney failure, liver failure. Your heart is not pumping out

0:31:17.560 --> 0:31:21.600
<v Speaker 4>enough blood, and really it's because you're not losing blood,

0:31:22.320 --> 0:31:24.440
<v Speaker 4>so you're not bleeding out, but you are losing so

0:31:24.560 --> 0:31:27.880
<v Speaker 4>much fluid from this process that your blood pressure just

0:31:27.920 --> 0:31:31.160
<v Speaker 4>can't keep up. We can also see really bad fluid

0:31:31.200 --> 0:31:35.440
<v Speaker 4>imbalances and electrolyte imbalances as well. So in this period

0:31:35.560 --> 0:31:41.880
<v Speaker 4>what's really important is fluid resuscitation as well as management

0:31:41.960 --> 0:31:44.440
<v Speaker 4>of these wounds to try and prevent all of this

0:31:44.440 --> 0:31:46.360
<v Speaker 4>stuff from getting worse. And in the case of those,

0:31:46.600 --> 0:31:49.560
<v Speaker 4>if we have circumferential burns and things, there has to

0:31:49.640 --> 0:31:52.080
<v Speaker 4>be like pressure relief, so you have to do some

0:31:52.160 --> 0:31:55.000
<v Speaker 4>kind of surgical intervention, even if it's something small, to

0:31:55.080 --> 0:31:57.520
<v Speaker 4>literally release that pressure so that you don't cause further

0:31:57.600 --> 0:32:01.200
<v Speaker 4>damage to the tissue or the tissue downstream. That Okay,

0:32:02.520 --> 0:32:07.360
<v Speaker 4>after that initial twenty four to seventy two hours after

0:32:07.400 --> 0:32:10.840
<v Speaker 4>a burn, your body enters a new phase that's called

0:32:10.880 --> 0:32:15.200
<v Speaker 4>the hyper dynamic and hyper metabolic flow phase. And you

0:32:15.240 --> 0:32:17.520
<v Speaker 4>can kind of think of this as your body like

0:32:17.800 --> 0:32:22.240
<v Speaker 4>releasing all the stress hormones that it has so you're

0:32:22.360 --> 0:32:25.120
<v Speaker 4>still alive. Your body has kept you alive for this

0:32:25.360 --> 0:32:31.360
<v Speaker 4>first few days, and now it's recognizing that without a

0:32:31.480 --> 0:32:36.320
<v Speaker 4>portion of your largest organ being able to thermoregulate, being

0:32:36.360 --> 0:32:39.480
<v Speaker 4>able to regulate the water in your body, being able

0:32:39.520 --> 0:32:42.640
<v Speaker 4>to protect you from infection. Your body is going to

0:32:42.680 --> 0:32:47.120
<v Speaker 4>have to compensate in a huge, huge way. So what

0:32:47.200 --> 0:32:50.120
<v Speaker 4>we see our blood vessels actually clamping down, so a

0:32:50.160 --> 0:32:54.240
<v Speaker 4>real decrease in vascular permeability. We see your heart rate

0:32:54.320 --> 0:32:59.320
<v Speaker 4>going up. We see the small blood vessels or the

0:32:59.320 --> 0:33:02.800
<v Speaker 4>microvascular of the area around that wound starting to heal

0:33:02.880 --> 0:33:06.440
<v Speaker 4>and redistribute blood to these areas to actually promote healing

0:33:06.520 --> 0:33:08.920
<v Speaker 4>rather than just like kind of freaking out like they

0:33:08.920 --> 0:33:12.760
<v Speaker 4>were at first. Right. And then we also see huge

0:33:12.960 --> 0:33:17.560
<v Speaker 4>increases in our basal metabolic rate, so our body literally

0:33:17.600 --> 0:33:22.240
<v Speaker 4>starts burning way more energy than it has in the past.

0:33:23.360 --> 0:33:26.560
<v Speaker 4>And what is so wild about burns are that these

0:33:26.760 --> 0:33:30.000
<v Speaker 4>changes in metabolism and total body functioning, like changes in

0:33:30.040 --> 0:33:35.160
<v Speaker 4>cardiac output, changes in insulin and glucose regulation, changes in

0:33:35.280 --> 0:33:42.040
<v Speaker 4>heat production, last for years following a severe burn. Really, yes,

0:33:42.160 --> 0:33:45.160
<v Speaker 4>So if we see body surface area burns of twenty

0:33:45.200 --> 0:33:48.320
<v Speaker 4>percent or greater than these changes in metabolism can last

0:33:48.360 --> 0:33:51.000
<v Speaker 4>for two or more years.

0:33:52.520 --> 0:33:56.120
<v Speaker 1>Yeah, and this is okay, I have so many questions

0:33:56.200 --> 0:33:56.960
<v Speaker 1>about everything.

0:33:57.360 --> 0:34:00.440
<v Speaker 2>Yeah, And that's like at that.

0:34:00.400 --> 0:34:03.719
<v Speaker 1>Point, what does the burn like, what does the burned

0:34:03.800 --> 0:34:06.760
<v Speaker 1>skin or tissue look like, has it been healed?

0:34:06.840 --> 0:34:07.440
<v Speaker 2>Is it scar?

0:34:08.520 --> 0:34:11.320
<v Speaker 4>Yeah? It really So it's really really going to depend

0:34:11.320 --> 0:34:16.080
<v Speaker 4>on what kind of treatment you have access to. Okay, yeah, right.

0:34:16.520 --> 0:34:19.200
<v Speaker 4>If you don't have access to any treatment, especially if

0:34:19.239 --> 0:34:23.319
<v Speaker 4>this was a deep burn, then the tissue that has

0:34:23.400 --> 0:34:25.480
<v Speaker 4>died is going to form what's called an esh scar.

0:34:25.760 --> 0:34:28.280
<v Speaker 4>I think that's how you say it, and that's basically

0:34:28.280 --> 0:34:29.680
<v Speaker 4>like you can think of it as a really really

0:34:29.719 --> 0:34:33.680
<v Speaker 4>bad scab. So something that's completely black, completely necrotic, can

0:34:33.719 --> 0:34:38.000
<v Speaker 4>be very thick, and it will take a very long time,

0:34:38.680 --> 0:34:44.920
<v Speaker 4>if ever, for that wound to heal completely because again,

0:34:45.120 --> 0:34:48.480
<v Speaker 4>if the burn extends all the way through the dermis,

0:34:48.480 --> 0:34:52.560
<v Speaker 4>so a deep partial thickness burn, or a complete thickness

0:34:52.680 --> 0:34:55.680
<v Speaker 4>burn so a late second degree to be or a

0:34:55.719 --> 0:35:01.200
<v Speaker 4>third degree burn or greater, there aren't any like dermal

0:35:01.360 --> 0:35:06.560
<v Speaker 4>cells left to re epithelialize, and so that wound has

0:35:06.600 --> 0:35:09.960
<v Speaker 4>to heal like from the bottom up, and it's really

0:35:10.239 --> 0:35:13.480
<v Speaker 4>a slow process and in some cases it just never

0:35:13.640 --> 0:35:18.800
<v Speaker 4>completely makes new skin again without some kind of wound management,

0:35:18.840 --> 0:35:20.719
<v Speaker 4>So that wound might never heal and it might become

0:35:20.760 --> 0:35:24.440
<v Speaker 4>a chronic wound, okay if you don't have any access

0:35:24.520 --> 0:35:29.200
<v Speaker 4>to essentially surgical debreatment and then treatment for it. So

0:35:29.239 --> 0:35:32.799
<v Speaker 4>that's mostly burns and kind of how severe they can be,

0:35:33.160 --> 0:35:35.680
<v Speaker 4>what damage they can cause. There's obviously a lot of

0:35:35.680 --> 0:35:38.520
<v Speaker 4>complications that can arise during the treatment of these burns.

0:35:38.760 --> 0:35:41.959
<v Speaker 4>You're at very high risk of infection because your skin

0:35:42.040 --> 0:35:45.480
<v Speaker 4>is the main barrier from infection, and depending on what

0:35:45.680 --> 0:35:49.000
<v Speaker 4>caused the burn, you might have additional like inhalational injuries,

0:35:49.080 --> 0:35:52.239
<v Speaker 4>and smoke inhalation deserves its whole own episode because that

0:35:52.239 --> 0:35:55.799
<v Speaker 4>can cause really severe injury. It deserves its whole, entire

0:35:55.840 --> 0:35:59.920
<v Speaker 4>own episode. But that's kind of like the main how

0:36:00.080 --> 0:36:03.320
<v Speaker 4>we deal with burns in terms of how our body

0:36:03.360 --> 0:36:06.839
<v Speaker 4>is responding to that burn, and the management is going

0:36:06.840 --> 0:36:08.880
<v Speaker 4>to really vary depending on what you have access to

0:36:08.960 --> 0:36:11.279
<v Speaker 4>and depending on how severe that burn is. But Erin,

0:36:12.320 --> 0:36:16.240
<v Speaker 4>I have to assume that we've been subject to vulnerable

0:36:16.320 --> 0:36:20.200
<v Speaker 4>to burns ever since I don't know forever, since we

0:36:20.280 --> 0:36:24.400
<v Speaker 4>lost our fur, like furry animals can still burn, tell me.

0:36:26.560 --> 0:36:27.400
<v Speaker 2>I will get there.

0:36:27.480 --> 0:36:29.719
<v Speaker 1>I do have one other question for you, though, and

0:36:29.760 --> 0:36:32.360
<v Speaker 1>that's just sort of like in general, you know, so

0:36:32.440 --> 0:36:34.560
<v Speaker 1>much of what I encountered in the history of burns

0:36:34.719 --> 0:36:38.280
<v Speaker 1>is that burns were it could be very, very fatal,

0:36:38.440 --> 0:36:41.160
<v Speaker 1>and they're not as much now today if you have

0:36:41.280 --> 0:36:43.799
<v Speaker 1>access to all these top of the line treatments and

0:36:43.840 --> 0:36:50.160
<v Speaker 1>burn centers. But what is behind or driving that mortality.

0:36:50.280 --> 0:36:53.560
<v Speaker 4>It really depends. It depends on the total body surface area.

0:36:53.600 --> 0:36:56.560
<v Speaker 4>There's actually like a calculator that you can use based

0:36:56.560 --> 0:37:01.520
<v Speaker 4>on someone's age and their body surface area to predict

0:37:01.719 --> 0:37:04.799
<v Speaker 4>essentially whether someone is likely to die from it. In

0:37:04.840 --> 0:37:07.360
<v Speaker 4>the case of severe burns, then it's that first like

0:37:07.440 --> 0:37:09.719
<v Speaker 4>twenty four to forty eight hours that you really need

0:37:09.760 --> 0:37:12.719
<v Speaker 4>access to resuscitation or somebody could die from shock and

0:37:12.880 --> 0:37:15.960
<v Speaker 4>organ failure. And then after that it's more likely to

0:37:15.960 --> 0:37:19.400
<v Speaker 4>be infection or potentially other complications like if there was

0:37:19.400 --> 0:37:22.080
<v Speaker 4>an inhalation injury or something like that. At the same time,

0:37:22.560 --> 0:37:24.680
<v Speaker 4>gotcha o kyeah, Okay.

0:37:26.360 --> 0:37:29.040
<v Speaker 1>Yeah, it is hm Aron, it is grim, and I

0:37:29.440 --> 0:37:33.319
<v Speaker 1>will say that the history is for a large part

0:37:33.480 --> 0:37:37.399
<v Speaker 1>is quite grim as well. But this is why I'm

0:37:37.440 --> 0:37:40.520
<v Speaker 1>so glad that we're doing these two episodes, is because

0:37:40.600 --> 0:37:44.440
<v Speaker 1>it really does exemplify how far we have come in

0:37:44.480 --> 0:37:48.880
<v Speaker 1>our ability to treat and manage burns. It's pretty remarkable,

0:37:48.960 --> 0:37:51.000
<v Speaker 1>Like it really is. Medical revolutions.

0:37:51.080 --> 0:37:51.920
<v Speaker 4>It's incredible.

0:37:52.360 --> 0:38:14.520
<v Speaker 1>But let's see where things came from. Okay, do you

0:38:14.560 --> 0:38:16.840
<v Speaker 1>remember your first bad burn?

0:38:18.280 --> 0:38:21.920
<v Speaker 4>I remember some really really bad sunburns when I was

0:38:21.960 --> 0:38:25.560
<v Speaker 4>a kid, probably that came close to a second degree.

0:38:25.600 --> 0:38:28.040
<v Speaker 4>They were so bad. But that's it. That's what I

0:38:28.040 --> 0:38:29.920
<v Speaker 4>can remember, really bad sunburns.

0:38:30.560 --> 0:38:35.120
<v Speaker 1>Yeah, yeah, a sunburn's probably like hot stove when you

0:38:35.160 --> 0:38:36.120
<v Speaker 1>were a child.

0:38:36.200 --> 0:38:37.879
<v Speaker 2>I'm sure that kind of thing.

0:38:38.000 --> 0:38:42.480
<v Speaker 1>Yeah, I am sure that I burned myself earlier than this,

0:38:42.800 --> 0:38:46.840
<v Speaker 1>But seared into my memory is the summer of nineteen

0:38:46.880 --> 0:38:51.440
<v Speaker 1>ninety seven. I was running around my friend's yard, Kathleen.

0:38:51.560 --> 0:38:54.759
<v Speaker 1>She lived down the street from us in Kentucky, and

0:38:54.840 --> 0:38:55.959
<v Speaker 1>we had a bonfire going.

0:38:56.040 --> 0:38:56.920
<v Speaker 2>You know, it was classic.

0:38:57.000 --> 0:38:59.759
<v Speaker 1>Got a bunch of neighbors there, hot dogs, some'mores, the

0:38:59.760 --> 0:39:04.680
<v Speaker 1>whole the whole nine yards, and I see a marshmallow

0:39:04.800 --> 0:39:08.040
<v Speaker 1>on the ground near the fire. Never wanting a marshmallow

0:39:08.080 --> 0:39:10.920
<v Speaker 1>to go to waste, I'd pick it up. And it

0:39:10.960 --> 0:39:12.759
<v Speaker 1>takes a few seconds to register that what I was

0:39:12.800 --> 0:39:15.719
<v Speaker 1>holding was not, in fact a delicious marshmallow, but it

0:39:15.800 --> 0:39:18.520
<v Speaker 1>was a white, hot ember that had shot out of

0:39:18.520 --> 0:39:19.880
<v Speaker 1>the fire and into the grass.

0:39:19.880 --> 0:39:21.600
<v Speaker 2>It was looked just like a marshmallow.

0:39:22.880 --> 0:39:25.760
<v Speaker 1>And I had a rough time for a few days,

0:39:25.760 --> 0:39:28.920
<v Speaker 1>but ultimately it was a very minor burn, Like very minor, right.

0:39:28.960 --> 0:39:31.480
<v Speaker 1>I iced my fingers, I covered them an aloe, I

0:39:31.520 --> 0:39:36.560
<v Speaker 1>soaked them in water, cold water overnight, and I was fine.

0:39:36.600 --> 0:39:39.359
<v Speaker 1>This story is not unique, and I'm sure everyone has

0:39:39.360 --> 0:39:42.240
<v Speaker 1>a story just like this, or one much much more severe,

0:39:42.520 --> 0:39:47.120
<v Speaker 1>because I was extremely lucky. Hundreds of millions of people

0:39:47.160 --> 0:39:50.160
<v Speaker 1>are burned every year, which is I would guess a

0:39:50.200 --> 0:39:54.960
<v Speaker 1>conservative estimate, and nearly two hundred thousand lose their lives

0:39:55.000 --> 0:39:59.400
<v Speaker 1>around the globe every year due to burn injuries. Burns

0:39:59.520 --> 0:40:03.160
<v Speaker 1>are a routine feature of our lives as human beings,

0:40:03.840 --> 0:40:06.880
<v Speaker 1>and that's been the case for a very long time.

0:40:07.680 --> 0:40:10.319
<v Speaker 1>My story of picking up a white hot ember, not

0:40:10.400 --> 0:40:13.200
<v Speaker 1>only is that a common story today, it's been a

0:40:13.239 --> 0:40:17.399
<v Speaker 1>common story for hundreds of thousands of years.

0:40:17.400 --> 0:40:20.320
<v Speaker 2>At least at least Okay.

0:40:20.480 --> 0:40:23.360
<v Speaker 1>Many a paper that describes the history of burn treatments

0:40:23.440 --> 0:40:27.560
<v Speaker 1>starts off with some variation of ever since man discovered fire,

0:40:27.719 --> 0:40:31.359
<v Speaker 1>he's had to deal with burns. Yeah, So many of

0:40:31.360 --> 0:40:32.440
<v Speaker 1>them start just like that.

0:40:33.120 --> 0:40:35.479
<v Speaker 2>And it's the truth. It is absolutely the truth.

0:40:35.520 --> 0:40:38.120
<v Speaker 1>I mean, sure, there may have been some hot springs,

0:40:38.160 --> 0:40:43.799
<v Speaker 1>accidents or severe sunburns, lightning strikes, wildfires, maybe that caught

0:40:43.880 --> 0:40:47.920
<v Speaker 1>up with early humans. And in this we're no different

0:40:48.000 --> 0:40:50.480
<v Speaker 1>than the other animals that have suffered the same fate

0:40:50.640 --> 0:40:53.799
<v Speaker 1>for the four hundred million years that fire has been

0:40:53.920 --> 0:40:58.200
<v Speaker 1>possible on this planet. Whoa, it wasn't possible before then,

0:40:58.400 --> 0:41:01.640
<v Speaker 1>it was only one no oxygen or why oxygen and

0:41:01.840 --> 0:41:02.800
<v Speaker 1>land plants?

0:41:03.080 --> 0:41:06.239
<v Speaker 4>Okay, okay, yeah, fascinating and really fascinating.

0:41:06.320 --> 0:41:10.680
<v Speaker 1>Yeah, but it's the domestication of fire that sets us apart.

0:41:11.520 --> 0:41:16.239
<v Speaker 1>Controlling and creating fire making fire gave us warmth, It

0:41:16.320 --> 0:41:20.080
<v Speaker 1>protected us from predators. It provided a means of cooking,

0:41:20.280 --> 0:41:23.960
<v Speaker 1>giving us access to higher quality and more easily digestible foods,

0:41:24.200 --> 0:41:27.040
<v Speaker 1>which provided the energy needed to fuel bigger brains. It

0:41:27.120 --> 0:41:31.840
<v Speaker 1>helped us to make tools, weapons, and ceramics. Fire is

0:41:31.880 --> 0:41:36.560
<v Speaker 1>a fundamental essential step in hominine evolution, second in importance

0:41:36.680 --> 0:41:39.879
<v Speaker 1>only to language, which may have been encouraged by fire.

0:41:41.440 --> 0:41:45.120
<v Speaker 1>Without fire, we would not have developed into the humans

0:41:45.120 --> 0:41:46.480
<v Speaker 1>that we are today.

0:41:46.760 --> 0:41:47.160
<v Speaker 4>Wow.

0:41:47.320 --> 0:41:47.719
<v Speaker 2>At all.

0:41:48.200 --> 0:41:50.960
<v Speaker 1>Burns are a consequence of fire domestication.

0:41:52.120 --> 0:41:58.560
<v Speaker 4>For the large lot Prometheus. Just kidding, sorry, deep cut,

0:41:58.719 --> 0:41:59.439
<v Speaker 4>I like it.

0:42:02.360 --> 0:42:05.680
<v Speaker 1>But as as our homin and ancestors learned to use

0:42:05.719 --> 0:42:09.880
<v Speaker 1>fire first by controlling wildfires, then making fires from scratch,

0:42:10.440 --> 0:42:14.080
<v Speaker 1>they were sure to suffer burns. Just last year, a

0:42:14.080 --> 0:42:16.920
<v Speaker 1>paper came out that pushed back the estimate of fire

0:42:17.080 --> 0:42:21.520
<v Speaker 1>making to like actually originating fire to four hundred thousand years.

0:42:22.080 --> 0:42:22.719
<v Speaker 4>Wow.

0:42:22.800 --> 0:42:27.440
<v Speaker 1>Wow, So researchers found compelling evidence of fire making in

0:42:27.480 --> 0:42:31.600
<v Speaker 1>eastern England in Neanderthal sites. Before this, the earliest evidence

0:42:31.680 --> 0:42:34.680
<v Speaker 1>was like fifty thousand years, which didn't mean that people

0:42:34.760 --> 0:42:36.759
<v Speaker 1>thought it wasn't older, but like this was like.

0:42:36.760 --> 0:42:40.279
<v Speaker 4>That was the evidence they had. Yeakay wow.

0:42:40.640 --> 0:42:44.200
<v Speaker 2>But it's likely that our Haminin relatives had been controlling.

0:42:43.719 --> 0:42:46.759
<v Speaker 1>Fire for much longer than that, perhaps as far back

0:42:46.760 --> 0:42:49.319
<v Speaker 1>as like one and a half million years. They would

0:42:49.360 --> 0:42:51.520
<v Speaker 1>have had to in order to migrate to regions with

0:42:51.640 --> 0:42:53.320
<v Speaker 1>colder climates in the first place.

0:42:53.680 --> 0:42:55.560
<v Speaker 2>Okay, all this is to say.

0:42:55.400 --> 0:42:58.520
<v Speaker 1>This is my long, my long winded way of saying,

0:42:58.840 --> 0:43:01.960
<v Speaker 1>ever since man discovered fire, that he's had to deal

0:43:02.000 --> 0:43:05.200
<v Speaker 1>with burns. Right, We've been dealing with burns for hundreds

0:43:05.200 --> 0:43:07.719
<v Speaker 1>of thousands of years. In the quest to harness fire.

0:43:08.040 --> 0:43:09.719
<v Speaker 4>Okay, And throughout all.

0:43:09.640 --> 0:43:13.440
<v Speaker 1>That time, humans have attempted to treat the burns that

0:43:13.480 --> 0:43:16.000
<v Speaker 1>they experienced, and of course we can only guess that

0:43:16.080 --> 0:43:19.040
<v Speaker 1>the variety of remedies used before the invention of writing,

0:43:19.160 --> 0:43:21.360
<v Speaker 1>but it's likely they were plant based. Like there is

0:43:21.440 --> 0:43:25.120
<v Speaker 1>some evidence for that, including a ghost citation I couldn't

0:43:25.120 --> 0:43:27.239
<v Speaker 1>track down, so I'm not going to even reference it.

0:43:27.320 --> 0:43:31.600
<v Speaker 1>But our earliest confirmed insight into the treatment of burns

0:43:31.640 --> 0:43:35.000
<v Speaker 1>comes from the medical texts from ancient civilizations that were

0:43:35.080 --> 0:43:38.560
<v Speaker 1>used to encountering, you know, the Ebers Papyrus, the Hippocratic texts,

0:43:38.920 --> 0:43:42.319
<v Speaker 1>medical treatises from China, writings by Shushruda, and so on.

0:43:43.040 --> 0:43:46.000
<v Speaker 1>The majority of these treatments for burns were centered on

0:43:46.239 --> 0:43:48.960
<v Speaker 1>the application of like a goo or an ointment or

0:43:49.000 --> 0:43:52.360
<v Speaker 1>a cream to the burn itself, to the actual location

0:43:52.440 --> 0:43:55.000
<v Speaker 1>of the burn, with a little bit on pain relief

0:43:55.040 --> 0:43:58.680
<v Speaker 1>and maybe early like debreedment type of approaches.

0:43:59.160 --> 0:43:59.399
<v Speaker 4>Okay.

0:44:00.400 --> 0:44:03.840
<v Speaker 1>Ancient Egyptian physicians seem to favor recipes that included resin

0:44:03.920 --> 0:44:08.239
<v Speaker 1>and honey or oil soaked linen wraps, but milk also.

0:44:07.960 --> 0:44:10.800
<v Speaker 2>Made an appearance, specifically.

0:44:10.200 --> 0:44:13.520
<v Speaker 1>Goat milk or milk from women who had given birth

0:44:13.560 --> 0:44:17.440
<v Speaker 1>to a son. I don't know if that means like

0:44:17.520 --> 0:44:19.320
<v Speaker 1>specific right, only sons?

0:44:19.520 --> 0:44:22.080
<v Speaker 2>Only just one son? Is okay? Do you have sons?

0:44:22.120 --> 0:44:26.000
<v Speaker 2>And you know, I don't know other.

0:44:25.400 --> 0:44:27.560
<v Speaker 4>Remedies like you had a son before, but now you

0:44:27.640 --> 0:44:30.560
<v Speaker 4>just had a daughter, Like does that is that okay?

0:44:30.719 --> 0:44:32.319
<v Speaker 2>I don't Yeah, you'll have to ask.

0:44:32.440 --> 0:44:33.360
<v Speaker 4>We need detail.

0:44:33.880 --> 0:44:38.000
<v Speaker 1>The author of the texts, yeah, whose might not be reachable.

0:44:38.520 --> 0:44:41.520
<v Speaker 1>But the other other remedies called for a sequence of

0:44:41.520 --> 0:44:45.120
<v Speaker 1>different ointments to be applied, so like day one black mud,

0:44:45.200 --> 0:44:47.800
<v Speaker 1>day two, boiled cow dung, so on, and so forth.

0:44:48.440 --> 0:44:51.520
<v Speaker 1>Animal products feature prominently in many of the recipes from

0:44:51.560 --> 0:44:54.960
<v Speaker 1>ancient Egypt, Greece, Rome, and India, not just milk, like,

0:44:55.040 --> 0:44:59.600
<v Speaker 1>for instance, bowls fat boiled with papyrus is one treatment.

0:45:00.120 --> 0:45:03.720
<v Speaker 1>The Hippocratic texts recommend that for a burn, you should

0:45:03.840 --> 0:45:06.920
<v Speaker 1>quote take melted fat of old pigs, mix it with

0:45:07.000 --> 0:45:10.160
<v Speaker 1>resin and bitumen, spread it out over a cloth, warm

0:45:10.200 --> 0:45:12.080
<v Speaker 1>it at the fire, and apply it as a plaster

0:45:12.800 --> 0:45:13.280
<v Speaker 1>end quote.

0:45:13.320 --> 0:45:13.560
<v Speaker 4>Okay.

0:45:14.239 --> 0:45:18.640
<v Speaker 1>Dung was also a popular choice, specifically hare's dung, and

0:45:18.719 --> 0:45:19.760
<v Speaker 1>she goat dung.

0:45:20.400 --> 0:45:24.680
<v Speaker 4>She goat, she goat, she goat, she goat, she okay,

0:45:25.040 --> 0:45:26.560
<v Speaker 4>she goat, she goat. Okay.

0:45:27.840 --> 0:45:30.440
<v Speaker 1>Eggs here and there we're mentioned, you know, hard boiled

0:45:30.520 --> 0:45:34.040
<v Speaker 1>yolks mixed with rose oil as an example. There were

0:45:34.040 --> 0:45:36.840
<v Speaker 1>also many plant based remedies as well, So an ancient

0:45:36.920 --> 0:45:40.600
<v Speaker 1>China tea leaf extract was applied to burns. In ancient India,

0:45:40.640 --> 0:45:43.319
<v Speaker 1>you might get an ointment made from butter mixed with

0:45:43.360 --> 0:45:46.400
<v Speaker 1>the bark of a fig tree. To quote from a

0:45:46.480 --> 0:45:49.480
<v Speaker 1>nineteen seventy seven paper by Thompson on the history of

0:45:49.480 --> 0:45:53.040
<v Speaker 1>burn treatment, quote it would be tedious and not a

0:45:53.080 --> 0:45:56.440
<v Speaker 1>little revolting to detail all the hundreds of variations on

0:45:56.480 --> 0:46:02.399
<v Speaker 1>this theme and quote fair enough enough, But hopefully I've

0:46:02.400 --> 0:46:05.800
<v Speaker 1>given you a small taste of the variations on the theme.

0:46:06.320 --> 0:46:08.600
<v Speaker 1>And I think that there are two main takeaways with

0:46:08.840 --> 0:46:12.560
<v Speaker 1>this foray into ancient burned treatment. First, there are a

0:46:12.600 --> 0:46:15.880
<v Speaker 1>lot of treatments, which suggests, of course, that this was

0:46:15.880 --> 0:46:19.560
<v Speaker 1>a problem encountered frequently enough to keep trying new things.

0:46:19.480 --> 0:46:23.360
<v Speaker 4>Right and everywhere, So everyone's got their own version of etrans.

0:46:22.960 --> 0:46:23.720
<v Speaker 2>Got their own version.

0:46:23.880 --> 0:46:28.800
<v Speaker 1>And because there was no clearly single reliable remedy, people

0:46:28.800 --> 0:46:33.600
<v Speaker 1>were constantly inventing new recipes. And second, by and large

0:46:33.640 --> 0:46:38.160
<v Speaker 1>treatments were topical aimed at promoting healing and providing relief,

0:46:39.080 --> 0:46:42.319
<v Speaker 1>and when you think of these in comparison to the

0:46:42.360 --> 0:46:46.120
<v Speaker 1>full scale, multi specialty approach that we use today, it's

0:46:46.160 --> 0:46:48.239
<v Speaker 1>barely a drop in the bucket. I mean, they were

0:46:48.239 --> 0:46:50.040
<v Speaker 1>doing the best that they could with the knowledge that

0:46:50.080 --> 0:46:53.839
<v Speaker 1>they had, and as that knowledge grew, so did their approaches,

0:46:54.280 --> 0:46:58.080
<v Speaker 1>but not necessarily with success, just sort of there were

0:46:58.120 --> 0:47:03.759
<v Speaker 1>limitations for thousands of years. By the Middle Ages, the

0:47:03.840 --> 0:47:07.239
<v Speaker 1>list of options for treating a burn had grown tremendously,

0:47:07.520 --> 0:47:09.919
<v Speaker 1>so sure, still plenty of people were opting for raw

0:47:09.920 --> 0:47:14.120
<v Speaker 1>onion slices, which remained popular for long, like a really

0:47:14.160 --> 0:47:18.040
<v Speaker 1>long time actually, with Ambrose Paree employing onions and salt

0:47:18.040 --> 0:47:22.439
<v Speaker 1>allegedly effectively in the sixteenth century. But there was one

0:47:22.560 --> 0:47:25.400
<v Speaker 1>sizeable shift in focus over that time, and that was

0:47:25.400 --> 0:47:30.960
<v Speaker 1>sort of towards temperature. Physicians found that topical treatments that

0:47:31.040 --> 0:47:35.600
<v Speaker 1>invoked a cooling sensation or were themselves cooling like melted snow,

0:47:36.120 --> 0:47:39.680
<v Speaker 1>provided relief to those with burns, especially with superficial burns.

0:47:40.160 --> 0:47:43.760
<v Speaker 1>Others suggested that treating like with like, so applying heat

0:47:43.800 --> 0:47:47.200
<v Speaker 1>to the burn would yield more positive results, especially for

0:47:47.239 --> 0:47:48.360
<v Speaker 1>those with deep wounds.

0:47:49.280 --> 0:47:49.640
<v Speaker 4>Okay.

0:47:50.000 --> 0:47:51.520
<v Speaker 2>Yeah.

0:47:51.560 --> 0:47:56.120
<v Speaker 1>The first book dedicated to burns des Combustion of Us

0:47:56.440 --> 0:48:00.000
<v Speaker 1>was written by Fabricious hild in Us in sixteen o seven,

0:48:00.080 --> 0:48:02.879
<v Speaker 1>and it warned that if cooling were applied to burn skin,

0:48:03.040 --> 0:48:05.560
<v Speaker 1>it would quote harden like fat when it is cooled,

0:48:05.600 --> 0:48:07.280
<v Speaker 1>and thus shut in the moisture.

0:48:07.920 --> 0:48:08.960
<v Speaker 4>How fascinating.

0:48:09.120 --> 0:48:12.319
<v Speaker 1>Okay, keep things warm, keep things more flowing is kind

0:48:12.320 --> 0:48:15.920
<v Speaker 1>of like their idea. But this book also was among

0:48:15.960 --> 0:48:21.000
<v Speaker 1>the first to propose treatments for contractors. Okay, but which

0:48:21.200 --> 0:48:21.480
<v Speaker 1>did you?

0:48:21.600 --> 0:48:22.880
<v Speaker 2>Did we talk about contractors?

0:48:23.040 --> 0:48:24.879
<v Speaker 4>No, but I'll talk more about it next week.

0:48:24.960 --> 0:48:28.000
<v Speaker 1>Okay, Okay, so we'll get there. Stay tuned for explanation

0:48:28.040 --> 0:48:32.439
<v Speaker 1>on contractors. But this idea of treating burns with heat,

0:48:32.880 --> 0:48:35.080
<v Speaker 1>it was kind of like to keep things flowing, prevent

0:48:35.280 --> 0:48:41.040
<v Speaker 1>fluid accumulation and encouraging this like, yeah, just free flow, freelow.

0:48:41.320 --> 0:48:41.600
<v Speaker 4>Okay.

0:48:42.480 --> 0:48:45.799
<v Speaker 1>Shakespeare even makes a reference to heat treatments in King

0:48:45.880 --> 0:48:51.000
<v Speaker 1>John and Falsehood Falsehood cures as fire cools fire within

0:48:51.080 --> 0:48:54.439
<v Speaker 1>the scorched veins of one new burned. I'm really great

0:48:54.440 --> 0:48:54.880
<v Speaker 1>at reading.

0:48:54.880 --> 0:48:57.799
<v Speaker 4>Shakespeare nailed it erin.

0:48:57.960 --> 0:48:58.840
<v Speaker 2>I remember for.

0:48:58.760 --> 0:49:01.600
<v Speaker 1>A really long time we had to do iambic pentameter

0:49:02.000 --> 0:49:06.000
<v Speaker 1>or speak an iamic pentameter in like tenth grade English.

0:49:06.040 --> 0:49:08.839
<v Speaker 1>And I was just like, I don't get it, and

0:49:09.320 --> 0:49:11.080
<v Speaker 1>it's been a block for me ever since.

0:49:11.200 --> 0:49:12.480
<v Speaker 2>So there you go.

0:49:13.320 --> 0:49:15.880
<v Speaker 1>But this debate cold versus heat, it went on for

0:49:16.040 --> 0:49:19.120
<v Speaker 1>hundreds of years, and it wasn't the only debate. There

0:49:19.200 --> 0:49:22.800
<v Speaker 1>was an argument over whether open air exposure or covering

0:49:22.880 --> 0:49:25.680
<v Speaker 1>a burn and dressing soaked with various substances was the

0:49:25.680 --> 0:49:26.400
<v Speaker 1>better approach.

0:49:26.880 --> 0:49:28.240
<v Speaker 2>Then there was a discussion over.

0:49:28.120 --> 0:49:31.359
<v Speaker 1>Which substances and which dressings, you know, whiskey, linseed oil,

0:49:31.400 --> 0:49:34.960
<v Speaker 1>olive oil, alkaline, water, leads, silver, linen, wool, cotton. Then

0:49:35.000 --> 0:49:37.680
<v Speaker 1>you could argue over whether you should feed your patient

0:49:37.719 --> 0:49:40.480
<v Speaker 1>and provide plenty of fluids or do some blood letting

0:49:40.480 --> 0:49:41.080
<v Speaker 1>and purging.

0:49:41.440 --> 0:49:41.560
<v Speaker 4>Oo.

0:49:42.239 --> 0:49:45.920
<v Speaker 1>Everyone had their favorite approach, backed up by an anecdote,

0:49:45.960 --> 0:49:48.040
<v Speaker 1>a gut feeling, professional pride.

0:49:48.280 --> 0:49:48.879
<v Speaker 4>Take your pick.

0:49:50.000 --> 0:49:52.840
<v Speaker 1>This lack of consensus on how to best manage burns

0:49:53.040 --> 0:49:56.360
<v Speaker 1>it plagued doctors throughout the Renaissance and into the seventeen

0:49:56.440 --> 0:50:01.120
<v Speaker 1>hundreds and eighteen hundreds. Wars, industrial as accidents and train

0:50:01.239 --> 0:50:05.120
<v Speaker 1>crashes served as a painful reminder that in fact, medicine

0:50:05.280 --> 0:50:08.960
<v Speaker 1>had not substantially advanced since the time of Galen and Hippocrates.

0:50:09.040 --> 0:50:13.160
<v Speaker 1>When it came to burns, what was needed to make

0:50:13.239 --> 0:50:18.359
<v Speaker 1>any type of progress was consensus, first and foremost on

0:50:18.440 --> 0:50:20.839
<v Speaker 1>how to measure the severity of burns and the rate

0:50:20.920 --> 0:50:24.719
<v Speaker 1>of healing, because only then could you compare treatments or approaches.

0:50:24.920 --> 0:50:28.439
<v Speaker 1>Only then could you pick lead ointment versus whiskey, ice

0:50:28.520 --> 0:50:31.480
<v Speaker 1>water versus warming cloths. Only then could you have a

0:50:31.520 --> 0:50:35.120
<v Speaker 1>hope of saving someone's life. How do you get consensus,

0:50:35.960 --> 0:50:40.040
<v Speaker 1>You gather data. In the early nineteenth century, Guillam Duputrin

0:50:40.200 --> 0:50:43.600
<v Speaker 1>reviewed fifty cases of burn patients and followed their treatments

0:50:43.600 --> 0:50:46.440
<v Speaker 1>and outcomes, and with this information he put together a

0:50:46.480 --> 0:50:50.600
<v Speaker 1>classification system for burns organized by depth, similar to the

0:50:50.600 --> 0:50:53.360
<v Speaker 1>degree system that many people are familiar with today that

0:50:53.400 --> 0:50:56.600
<v Speaker 1>we just went through. His was not the first burn

0:50:56.719 --> 0:50:59.960
<v Speaker 1>grading system overall, but it was the first to relate

0:51:00.160 --> 0:51:06.200
<v Speaker 1>burned severity, depth, and total area with mortality. With this system,

0:51:06.400 --> 0:51:09.600
<v Speaker 1>doctors were not just treating burns, they were measuring them.

0:51:10.600 --> 0:51:14.239
<v Speaker 1>Establishing this baseline was super important to compare different approaches.

0:51:14.320 --> 0:51:17.200
<v Speaker 1>You know, again, turpentine versus lindseed oil might look the

0:51:17.239 --> 0:51:20.479
<v Speaker 1>same in a severely burned individual, but if you tried

0:51:20.520 --> 0:51:23.680
<v Speaker 1>them out on a more moderate or minor burn, you

0:51:23.800 --> 0:51:27.279
<v Speaker 1>might see a difference in healing, right. And it also

0:51:27.320 --> 0:51:29.960
<v Speaker 1>opened the door to other kinds of treatments entirely, not

0:51:30.120 --> 0:51:33.759
<v Speaker 1>just those based on topical ointments, such as surgical approaches

0:51:33.880 --> 0:51:37.799
<v Speaker 1>you know, skin debreaedment and skin grafts, supportive therapies in

0:51:37.840 --> 0:51:41.400
<v Speaker 1>the form of fluid replenishment pain relief. By the end

0:51:41.440 --> 0:51:44.719
<v Speaker 1>of the nineteenth century, many, though not all, of the

0:51:44.760 --> 0:51:48.640
<v Speaker 1>pieces were there to revolutionize burn care. They were just

0:51:48.640 --> 0:51:52.239
<v Speaker 1>sort of scattered all over the place waiting for someone

0:51:52.320 --> 0:51:56.120
<v Speaker 1>to put them together. Up to this point, so around

0:51:56.640 --> 0:52:00.680
<v Speaker 1>I'm going to say early nineteen hundreds, much all of

0:52:00.760 --> 0:52:05.120
<v Speaker 1>human history, burns had remained out of reach for physicians,

0:52:05.200 --> 0:52:08.120
<v Speaker 1>who could at most hope for the body's innate wound

0:52:08.160 --> 0:52:12.120
<v Speaker 1>healing methods to kick in as they the doctors provided

0:52:12.160 --> 0:52:16.799
<v Speaker 1>some modicum of pain relief. Frankly speaking, medicine had made

0:52:16.840 --> 0:52:20.440
<v Speaker 1>no progress in increasing survival or healing in brace.

0:52:20.920 --> 0:52:23.560
<v Speaker 4>That's so wild, even into the nineteen hundreds.

0:52:23.560 --> 0:52:26.799
<v Speaker 1>Into the nineteen hundreds, And if this story so far

0:52:27.000 --> 0:52:32.520
<v Speaker 1>feels unsatisfying or incomplete, then I've succeeded. That's what that

0:52:32.640 --> 0:52:35.000
<v Speaker 1>was my aim here, Like I wanted to spend this

0:52:35.080 --> 0:52:38.040
<v Speaker 1>episode with this, my part of this episode taking us

0:52:38.080 --> 0:52:42.800
<v Speaker 1>through the desperate centuries and millennia in which medicine remained

0:52:43.000 --> 0:52:46.040
<v Speaker 1>completely in the dark, so that next week when we

0:52:46.160 --> 0:52:48.560
<v Speaker 1>get to share the story of how that changed, when

0:52:48.600 --> 0:52:50.759
<v Speaker 1>we get to really take stock of how far we've

0:52:50.800 --> 0:52:54.560
<v Speaker 1>come and stand a little bit in awe of scientific progress,

0:52:54.840 --> 0:52:57.799
<v Speaker 1>what funding for research has helped us to achieve, and

0:52:57.960 --> 0:53:01.560
<v Speaker 1>how working across disciplines can make a huge difference, so

0:53:01.600 --> 0:53:04.319
<v Speaker 1>that when we get there we get to go, oh

0:53:04.360 --> 0:53:06.600
<v Speaker 1>my god, Oh my gosh.

0:53:06.600 --> 0:53:08.040
<v Speaker 4>We've actually come so far.

0:53:08.239 --> 0:53:09.200
<v Speaker 2>We actually have.

0:53:10.400 --> 0:53:12.000
<v Speaker 1>But that's where I'm gonna stop it here, so I

0:53:12.160 --> 0:53:14.480
<v Speaker 1>learn it there. For now we can fill you in

0:53:14.560 --> 0:53:15.880
<v Speaker 1>on where you can read more.

0:53:16.280 --> 0:53:17.000
<v Speaker 4>There's a lot.

0:53:17.320 --> 0:53:19.480
<v Speaker 2>There is a lot. There is a lot.

0:53:20.360 --> 0:53:23.239
<v Speaker 1>So I'm going to shout out just three sources in particular,

0:53:23.520 --> 0:53:27.080
<v Speaker 1>there's nineteen eighty six History of burn Care by Pinnagar

0:53:27.160 --> 0:53:31.160
<v Speaker 1>and Pinnagar, then nineteen seventy seven Thompson Historical Landmarks and

0:53:31.200 --> 0:53:33.640
<v Speaker 1>the Treatment of Burns, and then by van He from

0:53:33.640 --> 0:53:36.239
<v Speaker 1>two thousand and seven from Fat of Old pigs to

0:53:36.400 --> 0:53:40.440
<v Speaker 1>fenestrated skin grafts. Oh, I have lots more, lots more.

0:53:40.440 --> 0:53:45.239
<v Speaker 4>I can't wait. My absolute favorite paper that I read

0:53:45.280 --> 0:53:49.040
<v Speaker 4>for this and next week's episode is by Jeshki. I'm

0:53:49.040 --> 0:53:50.799
<v Speaker 4>so sorry if I said that wrong at all, from

0:53:50.840 --> 0:53:53.600
<v Speaker 4>Nature Reviews. Disease primers love it when there's one of

0:53:53.600 --> 0:53:56.799
<v Speaker 4>these from twenty twenty called burn injury and it was.

0:53:57.080 --> 0:53:59.600
<v Speaker 4>I mean, it's so good, it's so comprehensive. It has everything,

0:53:59.760 --> 0:54:01.680
<v Speaker 4>but you know that there's also more. So if you

0:54:01.760 --> 0:54:06.680
<v Speaker 4>want way more in depth information about the response and

0:54:06.800 --> 0:54:10.000
<v Speaker 4>the path of physiology and all of this biology, don't

0:54:10.040 --> 0:54:12.200
<v Speaker 4>you worry because we have the list of all of

0:54:12.239 --> 0:54:15.120
<v Speaker 4>our sources on our website this podcast will kill You

0:54:15.400 --> 0:54:17.240
<v Speaker 4>dot com under the episode STAB.

0:54:17.480 --> 0:54:17.879
<v Speaker 2>We do.

0:54:18.719 --> 0:54:21.440
<v Speaker 1>Thank you to Bloodmobile for providing the music for this

0:54:21.520 --> 0:54:23.200
<v Speaker 1>episode and all of our episodes.

0:54:23.520 --> 0:54:27.440
<v Speaker 4>Thank you to Leanna and Tom and Mark and Pete

0:54:27.520 --> 0:54:29.600
<v Speaker 4>and everyone at exactly right.

0:54:31.480 --> 0:54:33.640
<v Speaker 2>Yes, thank you, probly everyone.

0:54:33.880 --> 0:54:37.000
<v Speaker 1>Thank you to everyone, and thank you to you listeners

0:54:37.640 --> 0:54:41.759
<v Speaker 1>and watchers, anyone who participates in this podcast in some way.

0:54:41.800 --> 0:54:44.640
<v Speaker 1>We really do appreciate you tuning in and telling us

0:54:44.640 --> 0:54:48.760
<v Speaker 1>what you think and just sharing this. I don't know everything,

0:54:49.000 --> 0:54:51.160
<v Speaker 1>Thank you for being you you, and.

0:54:51.200 --> 0:54:53.600
<v Speaker 4>A special shout out as always to our patrons. Thank

0:54:53.640 --> 0:54:56.759
<v Speaker 4>you so much for your support over on Patreon. It

0:54:56.920 --> 0:54:59.640
<v Speaker 4>really does mean so much to us, truly, truly.

0:55:00.600 --> 0:55:03.840
<v Speaker 2>Until next time, wash your hands you feel the animals.

0:55:08.800 --> 0:55:23.760
<v Speaker 1>Um um