WEBVTT - What's the deal with colostrum? 0:00:00.960 --> 0:00:06.120 Emily, when you pitch the idea of talking about colostrum 0:00:06.440 --> 0:00:11.240 to me, I thought of the human substance that comes 0:00:11.560 --> 0:00:15.880 from that comes from breasts, yep, after a mother has 0:00:16.200 --> 0:00:18.279 a baby. And you were like, no, no, no, it's 0:00:18.400 --> 0:00:22.520 huge in the endurance athlete space. And I have like 0:00:22.560 --> 0:00:28.840 these horrifying visions of like human women in factories, this 0:00:29.000 --> 0:00:33.879 totally dystopian view. And then I learned that this is 0:00:33.920 --> 0:00:38.720 not humans where this colostrum is coming from, Thank you God. 0:00:39.280 --> 0:00:41.919 It is still a little dystopian, and we can get 0:00:41.960 --> 0:00:45.960 into the baby cows. But I will tell you that 0:00:46.040 --> 0:00:48.639 when people first started asking me about should I take colostrum? 0:00:48.760 --> 0:00:51.479 I assumed that they were talking about their. 0:00:51.840 --> 0:00:55.520 Own colostrum, And often this question was phrased like should 0:00:55.560 --> 0:00:58.440 my husband take colostrum? And it's like, well, there's only 0:00:58.480 --> 0:01:00.720 a tiny amount of it, Like you know, if you 0:01:00.760 --> 0:01:03.440 have a baby, that colostrum, it's like the first milk 0:01:04.000 --> 0:01:06.600 that comes in. It's thicker, it's more yellow, but it's 0:01:06.640 --> 0:01:10.240 like so little, and it's like you're desperately trying to 0:01:10.240 --> 0:01:11.680 get some of it out for your baby. 0:01:11.680 --> 0:01:13.840 It's like, fuck you, what do you mean? Your husband's like. 0:01:13.800 --> 0:01:15.920 This guy's got a marathon tomorrow. 0:01:15.560 --> 0:01:16.440 So what are you going to go? 0:01:16.600 --> 0:01:18.200 Cycle? Like? Are you kidding me? 0:01:18.760 --> 0:01:24.119 And So we are talking about bovine colostrum in this episode, 0:01:24.160 --> 0:01:27.920 not human colostrum, which is a great food for babies, 0:01:27.959 --> 0:01:30.560 but should not be shared with your spouse even if 0:01:30.560 --> 0:01:32.520 they have a large endurance event. 0:01:32.600 --> 0:01:34.119 Coming up shortly. 0:01:34.080 --> 0:01:36.200 Cal colostrum coming right up. 0:01:38.880 --> 0:01:41.920 I'm Emily Oster. I'm an economist and a data expert. 0:01:42.040 --> 0:01:44.080 And I'm Perry Wilson, I'm a medical doctor. 0:01:44.760 --> 0:01:48.120 It's Thursday, May seventh, twenty twenty six. And this is 0:01:48.400 --> 0:01:50.400 wellness actually. 0:01:50.360 --> 0:01:53.840 Because you're getting a staggering amount of health and wellness 0:01:53.880 --> 0:01:57.720 information nowadays from every source imaginable, and some of it 0:01:57.760 --> 0:01:59.240 is awesome and some. 0:01:59.200 --> 0:02:02.120 Of it is well actually both. 0:02:03.080 --> 0:02:06.120 Fortunately we are both people who know how to read studies, 0:02:06.400 --> 0:02:08.679 how to parse the data, and can tell you what's 0:02:08.720 --> 0:02:11.560 worth thinking about and what you can safely ignore. 0:02:11.880 --> 0:02:14.160 But before we dig in, a note that this podcast 0:02:14.240 --> 0:02:16.800 is for educational purposes and should not be construed as 0:02:16.840 --> 0:02:20.040 medical advice. We don't know your unique situation, so talk 0:02:20.080 --> 0:02:22.200 to your doctor for personal health decisions. 0:02:23.040 --> 0:02:26.760 This week we're asking what's the deal with colostrum? Perry 0:02:26.800 --> 0:02:29.120 and I will give the official Smasher pass and then 0:02:29.120 --> 0:02:31.799 we'll get to your question of the week. But first 0:02:32.000 --> 0:02:47.840 let's do the health news roundup after the break, and 0:02:47.880 --> 0:02:50.400 now for the health news of the week, Perry, I 0:02:50.520 --> 0:02:55.079 want to start with a new trial in alcohol use 0:02:55.080 --> 0:02:59.560 disorder about ozembic, which I thought was really exciting. 0:02:59.720 --> 0:03:00.919 Did you think this was exciting? 0:03:01.639 --> 0:03:05.120 This is super exciting. The context here is that since 0:03:05.880 --> 0:03:09.160 ozepic has been a thing and been in diabetes and 0:03:09.160 --> 0:03:11.200 weight loss trials, there has been this, I don't know 0:03:11.240 --> 0:03:12.960 if you even want to call it a side effect, 0:03:13.000 --> 0:03:15.920 like an additional effect, which has been reported, which is 0:03:16.040 --> 0:03:19.079 people saying I'm not drinking as much alcohol and other 0:03:19.120 --> 0:03:22.239 things like not smoking as much, other sort of compulsive behaviors. 0:03:22.560 --> 0:03:26.200 But it hadn't really been formally tested, like let's do 0:03:26.280 --> 0:03:29.239 a trial specifically with this as the outcome. It was 0:03:29.240 --> 0:03:31.360 always just sort of icing on the cake. But this 0:03:31.440 --> 0:03:35.520 week we have a new randomized trial appearing in the Lancet, 0:03:35.520 --> 0:03:38.760 which randomized one hundred and eight participants about half men, 0:03:38.840 --> 0:03:43.640 half women. They all had alcohol use disorder. They all 0:03:43.960 --> 0:03:47.320 also had obesity, so they did have a like an 0:03:47.360 --> 0:03:50.960 FDA indication for ozempic. But the purpose of this trial 0:03:51.520 --> 0:03:54.040 was to see if the people that got ozepic versus 0:03:54.040 --> 0:03:58.200 placebo would have a reduction in days with heavy drinking, 0:03:58.520 --> 0:04:01.560 and indeed, they did a forty one percent reduction in 0:04:01.600 --> 0:04:04.760 the ozepic group compared to a twenty six percent reduction 0:04:05.080 --> 0:04:08.560 in the placebo group. That was statistically significant, and there 0:04:08.600 --> 0:04:12.480 was a bunch of other secondary effects that also suggested 0:04:13.000 --> 0:04:17.080 significantly less drinking. So, I mean, it's good news. 0:04:17.279 --> 0:04:18.120 It's really good news. 0:04:18.160 --> 0:04:22.080 I mean, we have relatively little treatment for alcohol use disorder. 0:04:22.200 --> 0:04:23.040 There are some. 0:04:23.080 --> 0:04:27.440 Medications, but they have pretty substantial side effects that make 0:04:27.480 --> 0:04:30.440 people not want to use them. They basically work by 0:04:30.440 --> 0:04:34.680 making drinking very unpleasant, and so this obviously works in 0:04:34.680 --> 0:04:37.360 a different way, and people describe it, at least anecdotally, 0:04:38.000 --> 0:04:41.320 it's more like you just don't want to drink, which 0:04:41.360 --> 0:04:43.760 is obviously much better than wanting to drink but then 0:04:43.800 --> 0:04:46.240 feeling bad when you do. So I thought this was 0:04:46.279 --> 0:04:48.240 really exciting. I think we'll be seeing more like this. 0:04:48.600 --> 0:04:50.760 I'd like to see some work on narcotics also, but 0:04:50.960 --> 0:04:52.520 I think that's probably down the line. 0:04:52.640 --> 0:04:55.080 Yeah, one hundred percent. I mean the big caveat here 0:04:55.160 --> 0:04:56.919 is that it does make you lose weight, and so 0:04:57.600 --> 0:05:00.400 this is not necessarily a therapy for people who are 0:05:00.560 --> 0:05:02.359 of normal weight to begin with, or you know, at 0:05:02.400 --> 0:05:04.680 some people with severe alcohol and drug use to sort 0:05:04.720 --> 0:05:06.840 of have are quite a bit underweight, so that'll sort 0:05:06.839 --> 0:05:09.880 of take this out of the picture for them. But 0:05:10.720 --> 0:05:13.839 really interesting to see some corroboration of the observational data 0:05:14.200 --> 0:05:19.600 on ozepic and alcohol use disorder. We need to close 0:05:20.080 --> 0:05:25.359 the book on perennial Surgeon General candidate doctor Casey Means, Emily, 0:05:26.400 --> 0:05:30.920 we the saga is over. I like to think we played, 0:05:30.960 --> 0:05:34.400 you know, perhaps a small part in the saga. So 0:05:34.480 --> 0:05:38.280 talk to me about no longer surgeon General candidate Casey Means, 0:05:38.320 --> 0:05:40.520 and where we are with this position that has been 0:05:40.600 --> 0:05:43.560 vacant for a long for a very long time. 0:05:43.680 --> 0:05:43.920 Yeah. 0:05:44.000 --> 0:05:47.240 So, so the surgeon general position has been vacant for 0:05:47.279 --> 0:05:49.600 a long time. I think it's an interesting question of 0:05:49.680 --> 0:05:52.000 kind of is that something we should be concerned about 0:05:52.360 --> 0:05:55.560 the surgeon general is it's some ways a largely symbolic 0:05:56.080 --> 0:05:59.680 role and so we're not exactly missing a lot of 0:05:59.720 --> 0:06:03.920 things milestones, let's say, but it is a role that 0:06:04.279 --> 0:06:07.200 needs to be filled. Casey Means has been on the 0:06:07.279 --> 0:06:12.560 ropes in terms of approval. For many months now, it's 0:06:12.600 --> 0:06:16.000 been she I think was caught up in this in 0:06:16.040 --> 0:06:20.640 the backlash wave to some of the anti vax activities 0:06:20.920 --> 0:06:22.680 of the RFK administration. 0:06:22.800 --> 0:06:27.320 You know, people have lost patients. Some people have lost 0:06:27.360 --> 0:06:30.279 patients with the resistance to vaccines. 0:06:30.320 --> 0:06:31.719 As more and more, Senator. 0:06:32.960 --> 0:06:35.320 Cassidy noticed a lot of piece people got measles. And 0:06:35.360 --> 0:06:37.679 he noticed that whatever deal he had made with Kennedy 0:06:37.800 --> 0:06:42.000 was not followed through on. And he's had enough and 0:06:42.200 --> 0:06:44.880 that has tanked the nomination. The White House was not 0:06:44.920 --> 0:06:49.000 interested in getting losing further capital on this, and they 0:06:49.000 --> 0:06:52.919 have now nominated someone named Nicole Safire Leaves how you 0:06:52.960 --> 0:06:56.000 say her name? Who seems like a very standard up 0:06:56.040 --> 0:06:56.920 the middle of candidate. 0:06:57.080 --> 0:06:59.839 Yeah, up the middle for this administration. I would say, 0:07:00.120 --> 0:07:02.920 doctor Perry. She's an actual I'll take it. I will 0:07:02.760 --> 0:07:05.479 tell she's a doctor. She's a real doctor. She's a 0:07:05.520 --> 0:07:08.280 breast radiologist at Memorial Sloan kettering. 0:07:08.360 --> 0:07:11.000 As a reasonable she's a Fox News contributor. But she's 0:07:11.040 --> 0:07:11.679 a real doctor. 0:07:11.720 --> 0:07:14.679 And I feel like that's my that's my bark's doctor. 0:07:14.880 --> 0:07:18.800 Great go, and I imagine she will get confirmed unless 0:07:18.800 --> 0:07:22.080 the position is truly cursed, as we have speculated on 0:07:22.160 --> 0:07:23.680 earlier episodes of this podcast. 0:07:24.280 --> 0:07:25.160 Thanks for be confirmed. 0:07:25.160 --> 0:07:28.240 We have to say, all right, last question, there is 0:07:28.280 --> 0:07:31.559 an outbreak of a haunt of virus on a cruise ship. 0:07:31.600 --> 0:07:35.320 People are stuck on this cruise ship off the coast 0:07:35.480 --> 0:07:40.160 of I believe West Africa, and a lot of them 0:07:40.160 --> 0:07:43.760 have haunted virus. Please tell us what is that and 0:07:44.480 --> 0:07:46.120 should people be concerned about it? 0:07:47.400 --> 0:07:50.960 Yeah, let's let's do the haunt of virus primer. So. 0:07:51.280 --> 0:07:55.119 Hantavirus is an RNA virus that exists all over the world. 0:07:55.320 --> 0:07:59.080 It is carried by rodents. The rodents generally are asymptomatic, 0:07:59.200 --> 0:08:01.120 so they just kind of carried around and they leave 0:08:01.160 --> 0:08:04.520 it in their feces and urine, and then when you 0:08:04.560 --> 0:08:07.840 go to clean up feces and urine, that virus gets aerosolized. 0:08:08.240 --> 0:08:11.280 You inhale it and it can cause very severe disease 0:08:12.360 --> 0:08:17.680 in the New World. There are two main forms of hantavirus, 0:08:17.720 --> 0:08:20.880 two species. The one that we would worry about here 0:08:20.920 --> 0:08:23.680 is called Andy's virus, which is common in Argentina where 0:08:23.720 --> 0:08:28.480 the cruise ship left from. Andy's virus has two notable features. 0:08:29.000 --> 0:08:31.320 One is that it is the most lethal of the 0:08:31.360 --> 0:08:33.800 Haunt of viruses, with about a thirty to fifty percent 0:08:34.040 --> 0:08:37.560 case mortality rate. Also, it's the only Hanta virus that 0:08:37.600 --> 0:08:40.079 has been shown to be capable of transmission person to 0:08:40.160 --> 0:08:43.360 person as opposed to mause to person. Okay, that all 0:08:43.440 --> 0:08:46.000 sounds scary, but to turn this down, I'm going to 0:08:46.040 --> 0:08:48.760 turn this down just a little bit. You know, so far, 0:08:49.000 --> 0:08:52.120 I think there are only five people with conf that 0:08:53.040 --> 0:08:57.480 have symptoms. Now, three people have died from this, so 0:08:57.520 --> 0:08:59.920 I mean this is severe on the cruise ship, but 0:09:00.040 --> 0:09:02.120 it's not like the whole cruise ship was infected. I 0:09:02.120 --> 0:09:05.640 think that's important. Also, two of the people that died 0:09:05.679 --> 0:09:08.120 were husband and wife, So if there was person to 0:09:08.200 --> 0:09:11.719 person transmission, which is suspected in Andy's virus, it does 0:09:11.800 --> 0:09:15.360 require very close contact and like exchange of bodily fluids 0:09:15.360 --> 0:09:18.280 and things like that. This is not an airborne virus, 0:09:18.840 --> 0:09:21.960 so you know, the public health risk is quite low 0:09:22.080 --> 0:09:26.320 unless you're interacting extremely closely with someone who's infected. The 0:09:26.640 --> 0:09:30.200 argument to quarantine this ship is actually not strong. I 0:09:30.200 --> 0:09:33.760 don't think because of that. The risk really comes from 0:09:33.800 --> 0:09:36.600 the droppings, not from the people who are infected who 0:09:37.160 --> 0:09:40.560 need to be in hospitals and getting very close supportive care. 0:09:40.600 --> 0:09:42.720 There's no treatment, but you know they need to be 0:09:42.760 --> 0:09:43.840 an intensive care unit. 0:09:44.400 --> 0:09:44.679 Yeah. 0:09:44.679 --> 0:09:49.000 But on the other hand, people, We're hundreds of years 0:09:49.040 --> 0:09:51.960 into people being concerned about diseases on boats being spread 0:09:52.000 --> 0:09:55.320 to the population, and so I'm not that surprised that 0:09:55.559 --> 0:09:59.400 we are quarantining this ship. I do want to say 0:09:59.520 --> 0:10:02.200 that a lot of people do get sick on cruise ships, 0:10:02.200 --> 0:10:05.080 but this is not like a major risk factor on 0:10:05.200 --> 0:10:07.160 cruise ships. The main disease you get on the cruise 0:10:07.160 --> 0:10:09.440 ship is a neural virus, which is almost one hundred 0:10:09.480 --> 0:10:10.839 percent chance of getting Yeah. 0:10:10.880 --> 0:10:13.600 Oh yeah, Once nora virus breaks out, it's it is 0:10:13.720 --> 0:10:14.200 all over. 0:10:14.679 --> 0:10:18.559 You're getting it. But this is rare, Although obviously scary, 0:10:19.080 --> 0:10:20.000 it does. 0:10:19.760 --> 0:10:22.360 Add to my ever growing list of reasons I never 0:10:22.360 --> 0:10:24.000 want to go on a cruise. But this is the 0:10:24.000 --> 0:10:25.720 first case I've seen of hantavirus. 0:10:26.240 --> 0:10:30.920 Don't I don't go on boats due to stomach issues. 0:10:31.240 --> 0:10:33.880 We should just say people, if you're cleaning up your 0:10:34.040 --> 0:10:37.560 house and you're worried about mouse or rat droppings, you 0:10:37.600 --> 0:10:40.960 want to spray those with a bleach containing solution before 0:10:41.000 --> 0:10:43.760 you clean them up, and ideally not vacuum because that 0:10:43.800 --> 0:10:46.679 can really aerosolize things. There is hantavirus in the US. 0:10:46.880 --> 0:10:50.760 Gene Hackman's wife died of hantavirus, although apparently there were 0:10:50.800 --> 0:10:53.840 a lot of There was a pretty bad roadent infestation 0:10:53.880 --> 0:10:56.360 in the house. So you know, be careful, but there'sn't 0:10:56.520 --> 0:10:57.920 something to panic about quite yet. 0:10:58.000 --> 0:11:00.920 Be careful, but don't panic. Yep, all right, that's it 0:11:00.960 --> 0:11:02.800 for the health news of the week. After the break. 0:11:03.040 --> 0:11:09.960 What's the deal with colostrum? 0:11:10.240 --> 0:11:14.160 This is raw colostrum so powerful it's actually banned in 0:11:14.280 --> 0:11:18.160 NC DOUBLEA. Yes, college sports banned colostrum because it contains 0:11:18.200 --> 0:11:20.840 IGF one, insulin like growth factor one. It's associated with 0:11:20.880 --> 0:11:24.240 increased muscle growth and vitality, increased levels of HDL and humans. 0:11:24.320 --> 0:11:27.600 Colostrum muscle contains a ton of different immune globulins which 0:11:27.679 --> 0:11:30.559 support the health of the gut. Also proleine rich peptides 0:11:30.600 --> 0:11:33.800 like colosterrne and that support the immune system and the thymus. 0:11:33.880 --> 0:11:34.920 This stuff is liquid gold. 0:11:34.920 --> 0:11:37.160 It's the first milk cows give to their calves and 0:11:37.200 --> 0:11:40.600 it helps program their gut and across species, mammalian milk 0:11:40.679 --> 0:11:42.679 is very healthy for humans. So if you can find 0:11:42.679 --> 0:11:46.040 somewhere to get a colostrum, probably a raw colostrum. This 0:11:46.080 --> 0:11:48.520 stuff is incredible for your gut, for your immune system, 0:11:48.520 --> 0:11:50.120 incredible for muscle growth and recovery. 0:11:50.200 --> 0:11:51.520 I love this stuff. However you can get it. 0:11:51.559 --> 0:11:53.560 Colossrum is a super food banned by the NC DOUBLEA 0:11:53.679 --> 0:11:55.720 good for me, good for you. This stuff is amazing. 0:11:55.800 --> 0:11:57.440 I'm going to go home and drink a bunch of 0:11:57.440 --> 0:11:58.320 colostrum right now. 0:11:58.440 --> 0:12:00.240 I love that clip, Perry, because I think I think 0:12:00.240 --> 0:12:04.880 it illustrates a very common wellness influencer talking point, which is, 0:12:05.040 --> 0:12:07.320 you know this is like why would they ban this 0:12:07.400 --> 0:12:08.600 if it wasn't great? 0:12:09.040 --> 0:12:11.560 I mean we've made that talking point several timetally. 0:12:12.000 --> 0:12:14.200 Yes, I'm always making that point, like, you know, this 0:12:14.240 --> 0:12:15.960 must be good for performance if they ban it in 0:12:16.040 --> 0:12:20.480 professional cycling. So I'm convinced. But before we talk about 0:12:20.480 --> 0:12:23.960 how we should all be consuming the milk of that 0:12:24.200 --> 0:12:26.800 is intended for baby cows, I think we should talk 0:12:26.840 --> 0:12:32.040 about what this is and why it might be helpful. 0:12:32.080 --> 0:12:33.760 So let me start with the what it is, and 0:12:33.800 --> 0:12:35.960 then I'm going to pass to you for like what 0:12:36.559 --> 0:12:39.000 might possibly be going on, which is, you know, so 0:12:39.400 --> 0:12:42.520 bovine colostrum is the colostrum from cows literally, so it's 0:12:42.559 --> 0:12:46.160 the first milk that is produced by the female lady 0:12:46.200 --> 0:12:51.479 cow after she calves, and it has like human colostrum 0:12:51.520 --> 0:12:54.439 has a different composition than more mature human breast milk. 0:12:54.640 --> 0:13:00.480 Bovine colostrum has a different concentration of various features than 0:13:01.200 --> 0:13:04.520 mature milk. And the idea is that somehow this would 0:13:04.600 --> 0:13:09.840 be helpful for something. And I actually, relative to some 0:13:09.960 --> 0:13:13.920 of the things we talk about, those fill ins are 0:13:13.960 --> 0:13:17.280 to me very vague. This is a lot of it 0:13:17.360 --> 0:13:20.600 feels like that influencer clip where it's just a list 0:13:20.640 --> 0:13:23.120 of things that one might be interested in and how 0:13:23.160 --> 0:13:26.319 they might be good here, but with no real connection. Yeah, 0:13:26.360 --> 0:13:30.559 so is there something biologically behind anything here? 0:13:31.040 --> 0:13:34.640 Yeah, it's always so complicated when we're talking about like 0:13:34.760 --> 0:13:39.800 a natural substance instead of a chemical or a single chemical. Right, 0:13:40.040 --> 0:13:41.839 even when we talk about something like as simple as 0:13:41.920 --> 0:13:43.880 coffee and like, oh, this study showed that you know, 0:13:43.920 --> 0:13:46.160 coffee was beneficial for X, Y or Z, And it's like, okay, 0:13:46.160 --> 0:13:49.480 well coffee is eight million different things, right, Yes, there's caffeine, 0:13:49.480 --> 0:13:51.440 but there's also all this other stuff, and it's very 0:13:51.480 --> 0:13:55.400 hard to untangle, and colossrum is no different. It is 0:13:55.720 --> 0:14:00.959 clearly a biologically very important substance. All mammals produce colostrum 0:14:01.120 --> 0:14:03.400 before they produce milk, and as you pointed out, it 0:14:03.480 --> 0:14:05.559 is quite a bit different from like, you know, the 0:14:05.840 --> 0:14:09.160 milk that comes in later, and animals that don't get 0:14:09.240 --> 0:14:14.640 colostrum from their mother early certainly do worse in a 0:14:14.760 --> 0:14:18.280 variety of ways. So it is something important. I think 0:14:18.280 --> 0:14:20.440 when I was kind of listening to you know, what 0:14:20.760 --> 0:14:23.960 influencers are talking about and people who support colostrum a lot, 0:14:24.040 --> 0:14:27.080 there's a few substances in there that kind of keep 0:14:27.120 --> 0:14:29.760 getting mentioned, and I think we'll probably want to focus 0:14:29.760 --> 0:14:33.880 on those as like the biologically relevant ones. The first 0:14:33.920 --> 0:14:37.560 is probably IGF one or insulin like growth factor one. 0:14:37.960 --> 0:14:42.280 There are anywhere between fifty and two thousand micrograms per 0:14:42.360 --> 0:14:47.800 leader of IGF one in col colostrum compared to like 0:14:47.920 --> 0:14:51.840 less than ten micrograms basically undetectable in mature cow milk. 0:14:51.880 --> 0:14:55.680 This is from the Bulgarian Journal of Veterinary Science, you know, 0:14:55.880 --> 0:14:58.200 not maybe the number one veterinary journal in. 0:14:58.200 --> 0:15:01.560 The world, not impact factor of it, okay. 0:15:01.360 --> 0:15:04.760 But actually the best study unlike the content, the actual 0:15:04.800 --> 0:15:07.040 measurements of what's in this stuff that I could find. 0:15:07.960 --> 0:15:10.120 So and I think let's if can we talk about 0:15:10.120 --> 0:15:12.880 IGF one is like, because I think this will give 0:15:12.880 --> 0:15:15.680 a framework for how to think about stuff that you eat. So, 0:15:16.160 --> 0:15:19.840 what IGF one is is the molecule that mediates the 0:15:19.840 --> 0:15:23.800 effects of growth hormone. So your pituitary gland releases growth hormone, 0:15:24.280 --> 0:15:28.280 particularly when you're growing, and downstream that tells your body 0:15:28.280 --> 0:15:30.360 to grow, tells your bones and your muscles to grow, 0:15:30.360 --> 0:15:32.440 and for you to get taller. That's what growth hormone does. 0:15:32.640 --> 0:15:34.800 But it doesn't do it itself. It doesn't act itself. 0:15:34.800 --> 0:15:36.960 It acts on the liver to release IGF one, and 0:15:37.000 --> 0:15:39.000 then igf one is the thing that tells your muscles 0:15:39.000 --> 0:15:41.040 and stuff to grow. So it's just a two step process. Okay, 0:15:41.040 --> 0:15:44.600 that's IGF one. Kids who are born with like genetic 0:15:44.600 --> 0:15:48.720 deficiencies of IGF one or growth hormone have congenital short 0:15:48.760 --> 0:15:53.640 stature syndromes, so you know, little people types of syndromes. 0:15:54.240 --> 0:15:58.200 IGF one is banned by the nc double A and 0:15:58.360 --> 0:16:02.000 the World Antidoping Association, And you can inject IGF one 0:16:03.160 --> 0:16:06.360 because it does grow muscles. It is a growth factor. 0:16:07.160 --> 0:16:10.240 In fact, there is concern about some people who are 0:16:10.280 --> 0:16:13.240 concerned about our intake of dairy point to IGF one 0:16:13.280 --> 0:16:16.280 and they're like, dairy causes cancer because of IGF one, right, 0:16:16.320 --> 0:16:18.040 because of the growth signals from IGF one. So you 0:16:18.120 --> 0:16:20.280 always get these millions of sides. But there's a couple 0:16:20.360 --> 0:16:22.200 of things we need to think about when it comes 0:16:22.200 --> 0:16:25.440 to a cow product. Number One, are we pasteurizing it. 0:16:26.080 --> 0:16:30.600 If we're pasteurizing it, some proteins lose their functionality, some don't. 0:16:31.240 --> 0:16:35.880 Number Two, can it get absorbed intact through your GI tract? 0:16:35.960 --> 0:16:38.480 And this is the big one where kind of a 0:16:38.680 --> 0:16:44.400 lot of the biological plausibility falls apart when it comes 0:16:44.400 --> 0:16:45.960 to IGF one, And this will be the case for 0:16:46.120 --> 0:16:50.360 multiple things. That's in cow colostrum. You can give it 0:16:50.360 --> 0:16:52.880 to people. In fact, it's heat stable IGF one, So 0:16:52.920 --> 0:16:54.800 you can even pasteurize this stuff and it still has 0:16:54.800 --> 0:16:57.360 IGF one in it, but it does not get into 0:16:57.400 --> 0:17:00.000 the blood. Some studies that suggest it does get into 0:17:00.120 --> 0:17:02.640 the blood see fragments of IGF one, But that's just 0:17:02.760 --> 0:17:05.280 digested stuff, it's not the actual molecule. 0:17:05.520 --> 0:17:08.359 Yeah, I think that this point comes up actually a 0:17:08.440 --> 0:17:12.240 lot in this space of linking. You know, this is 0:17:12.280 --> 0:17:14.679 a substance in this food to this is going to 0:17:14.720 --> 0:17:18.560 have this impact where we know the substance is something 0:17:18.600 --> 0:17:21.000 where like if you injected it ad mice, right, Really, 0:17:21.040 --> 0:17:22.760 what you're saying here is like if you take IGF 0:17:22.760 --> 0:17:24.880 one and you inject it in a mouse or even 0:17:24.920 --> 0:17:26.879 in a person, Yeah, like that's good. 0:17:26.960 --> 0:17:28.080 You know, That's why they don't let you go. 0:17:28.200 --> 0:17:30.600 It's not necessarily good for you, but it'll make your 0:17:30.640 --> 0:17:31.920 muscles grow a bit. It'll make your. 0:17:31.920 --> 0:17:34.200 Muscles grow, and so you can get a super muscular 0:17:34.240 --> 0:17:38.000 mouse by injecting them with igf one. But our digestive 0:17:38.040 --> 0:17:40.800 system is not the same as injecting things. 0:17:40.480 --> 0:17:40.920 Not at all. 0:17:41.000 --> 0:17:43.920 Right, Like when you when you consume something, it goes 0:17:44.000 --> 0:17:46.880 through your stomach, and your stomach is full of acids 0:17:46.920 --> 0:17:49.560 and other stuff, and it breaks it down in all 0:17:49.640 --> 0:17:52.960 kinds of ways. And so there are many things, for example, 0:17:53.000 --> 0:17:55.880 even GLP ones, where there is a reason it's taken 0:17:55.920 --> 0:17:57.880 a long time to get to an oral GLP one 0:17:57.960 --> 0:18:02.120 because the injected version is just so much more accessible 0:18:02.280 --> 0:18:03.040 to our body. 0:18:03.359 --> 0:18:06.000 And so I actually believe if. 0:18:05.840 --> 0:18:08.520 We looked into it, there's many things in this space 0:18:08.560 --> 0:18:11.400 where that that is the link that kind of breaks 0:18:11.440 --> 0:18:14.439 when people go from here is something where we know 0:18:14.480 --> 0:18:16.119 if we injected it in a mouse, it would matter 0:18:16.520 --> 0:18:18.639 to you know, here is something you can take by mouth, 0:18:18.920 --> 0:18:22.159 because the amount that you have accessible after you consume 0:18:22.200 --> 0:18:23.719 it through your stomach is like nothing. 0:18:24.119 --> 0:18:27.879 Yeah, yeah, it's it's really hard, and pharmacologists spend a 0:18:27.880 --> 0:18:29.360 lot of time trying to figure out how to get 0:18:29.359 --> 0:18:32.560 your body to absorb something without digesting. It's it's just 0:18:32.680 --> 0:18:35.840 a tricky problem and it's not solved in colostrum. So 0:18:36.640 --> 0:18:39.280 I'm actually I think that like a colostrum if you 0:18:39.320 --> 0:18:42.240 dig into the NC double A rules on this. The 0:18:42.400 --> 0:18:46.359 reason they ban colostrum is actually they say that it's 0:18:46.520 --> 0:18:50.880 risky because potentially of false positives in your blood. It's 0:18:50.880 --> 0:18:52.399 like similar to how like you might not want to 0:18:52.400 --> 0:18:54.679 eat a lot of poppy seeds if you're getting like 0:18:54.720 --> 0:18:57.200 an opioid test, right, It's not because the poppy seeds 0:18:57.200 --> 0:18:59.040 make you high. It's because they have kind of similar 0:18:59.119 --> 0:19:02.080 chemical structure. You get little pieces of IGF one in 0:19:02.119 --> 0:19:04.679 your bloodstream after it's digested, But then the test that 0:19:04.720 --> 0:19:06.720 they give you is like, oh, he's using IGF one. 0:19:07.040 --> 0:19:09.479 So, in fact, perry a lot of people when they 0:19:09.480 --> 0:19:13.159 get popped for doping, the excuse is I ate a 0:19:13.440 --> 0:19:16.480 food where the animal was fed growth hormone. 0:19:16.640 --> 0:19:20.119 Okay, there you go, Yes, you know. That is why 0:19:20.200 --> 0:19:25.320 I exclusively drink milk that has been extensively treated with 0:19:25.359 --> 0:19:27.639 bovine growth growth hormone. 0:19:28.200 --> 0:19:29.520 When they test you at the end of the five 0:19:29.600 --> 0:19:30.879 K so I'm not getting tested. 0:19:30.920 --> 0:19:31.440 I just trying. 0:19:31.880 --> 0:19:34.280 I'm just trying to hit the golf ball further. That's 0:19:34.280 --> 0:19:35.600 all I care about, just trying. 0:19:35.640 --> 0:19:35.960 Okay. 0:19:36.200 --> 0:19:40.480 So when we look at the particular items in colostrum, 0:19:40.520 --> 0:19:42.240 and I think this is important to set the stage 0:19:42.280 --> 0:19:44.960 for like looking at the at the data on it, 0:19:46.000 --> 0:19:51.560 there's the growth hormones. There are a bunch of other things, immunoglobulins. 0:19:52.000 --> 0:19:53.560 Yeah, we should definitely talk about that. 0:19:53.960 --> 0:19:55.840 I will say big we should talk about all these things. 0:19:55.840 --> 0:19:59.800 But big picture, one of the issues with biological plausibility 0:19:59.840 --> 0:20:02.600 for this substance at all is that almost all these 0:20:02.600 --> 0:20:05.879 things are not really available once you eat them. 0:20:06.240 --> 0:20:09.000 Yes, that's correct, most things are digested. I'm going to 0:20:09.119 --> 0:20:11.359 like put one coin on the other side of the 0:20:11.400 --> 0:20:16.280 scale though. Let's give colostrum it's due not everything that 0:20:16.320 --> 0:20:19.680 affects your body has to get into your body, true, 0:20:20.240 --> 0:20:26.560 and so for example, immunoglobulins. Immunoglobulins are little those are antibodies, 0:20:26.720 --> 0:20:32.919 and your body makes them against certain antigens like bacteria, viruses, 0:20:33.680 --> 0:20:37.199 stuff like that. The antibodies sticky, they're each specific to 0:20:37.240 --> 0:20:39.240 one of those antigens. They stick to it, and it's 0:20:39.280 --> 0:20:40.720 sort of a signal to your body like this is 0:20:40.760 --> 0:20:42.800 a bad thing. It's marked for death, like take care 0:20:42.840 --> 0:20:45.679 of it, and the whole cascade immune cascade follows. There 0:20:45.680 --> 0:20:49.600 are different types of immunoglobulins, but one that's very relevant 0:20:49.600 --> 0:20:53.920 here is called IgA immunoglobulin A, which is the immunoglobulin 0:20:54.119 --> 0:20:59.520 that lives in your mucosal system, so in your nose, mouth, throat, 0:20:59.600 --> 0:21:03.479 and GI tract. This is the frontline immunoglobulin. It's actually 0:21:03.520 --> 0:21:08.840