1 00:00:01,560 --> 00:00:04,760 Speaker 1: Welcome to stuff from the science Lab from how stuff 2 00:00:04,760 --> 00:00:15,880 Speaker 1: works dot com. Wow, Hey, this is Alson I don't know, 3 00:00:16,079 --> 00:00:18,040 Speaker 1: the science senator at how stuff works dot com. And 4 00:00:18,079 --> 00:00:20,200 Speaker 1: this is Robert Lamb, science writer at how stuff works 5 00:00:20,239 --> 00:00:24,119 Speaker 1: dot com. Alison, you know the old saying spoonful of 6 00:00:24,120 --> 00:00:26,040 Speaker 1: sugar makes the medicine go down? I do? I do? 7 00:00:26,160 --> 00:00:30,320 Speaker 1: Is that Mary Poppins? Um? I think so? Um. Mary 8 00:00:30,360 --> 00:00:33,120 Speaker 1: Poppins said that famously, And the whole idea is because 9 00:00:33,159 --> 00:00:36,640 Speaker 1: the medicine is so horrible, just taste so yucky that 10 00:00:36,840 --> 00:00:38,839 Speaker 1: you've got to have a massive amount of sugar to 11 00:00:38,840 --> 00:00:40,800 Speaker 1: get a child to take it. The child will choose 12 00:00:40,800 --> 00:00:43,120 Speaker 1: death over the yucky taste. So you've got to have 13 00:00:43,159 --> 00:00:45,640 Speaker 1: an appropriate amount of sweetness to cancel it out. Right, Well, 14 00:00:45,680 --> 00:00:46,920 Speaker 1: you know you can get the drugs right now and 15 00:00:47,000 --> 00:00:50,720 Speaker 1: choose your flavoring. Well yeah, yeah, but but great flavoring. 16 00:00:50,720 --> 00:00:53,040 Speaker 1: It's still pretty fat. That's still that's like basically they're 17 00:00:53,040 --> 00:00:55,320 Speaker 1: still doing the same thing. They're giving you the spoonful 18 00:00:55,360 --> 00:00:58,680 Speaker 1: of sugar or awful great flavoring whatever to mask the 19 00:00:58,680 --> 00:01:00,920 Speaker 1: odiousness of the medicine, and it tends not to really 20 00:01:01,000 --> 00:01:02,560 Speaker 1: mask it. It's like like if you ever had your 21 00:01:02,560 --> 00:01:05,280 Speaker 1: teeth polished and they use that the stuff that's it's 22 00:01:05,280 --> 00:01:07,520 Speaker 1: not mint flavored, but it's like cherry flavored, So it 23 00:01:07,600 --> 00:01:10,280 Speaker 1: ends up not being it's not really cherry. It's just 24 00:01:10,360 --> 00:01:14,319 Speaker 1: kind of a slightly it's even more yucky for trying 25 00:01:14,360 --> 00:01:16,720 Speaker 1: to be something it's not. You know, yes, yes, but 26 00:01:16,840 --> 00:01:20,480 Speaker 1: this leads to question, um, how much sugar If it's 27 00:01:20,520 --> 00:01:23,319 Speaker 1: one spoonful of sugar to counteract the medicine, how much 28 00:01:23,319 --> 00:01:26,479 Speaker 1: sugar would you need if the cure for your sickness was, say, 29 00:01:26,560 --> 00:01:31,400 Speaker 1: a snake bite or a sting from some sort of 30 00:01:31,480 --> 00:01:36,319 Speaker 1: venomous spider. Quite a lot of sugar, right, so it seems. Yeah, 31 00:01:36,360 --> 00:01:38,800 Speaker 1: so that's what we're talking about today. That's our roundabout 32 00:01:38,840 --> 00:01:42,760 Speaker 1: in to to the use of venoms as and the 33 00:01:42,840 --> 00:01:45,280 Speaker 1: virtues of venom. Actually, I think the venom really gets 34 00:01:45,280 --> 00:01:47,320 Speaker 1: a bad rap, namely because when we think of venom, 35 00:01:47,360 --> 00:01:50,560 Speaker 1: we think of horrible pain. Yeah, we think of you know, 36 00:01:50,760 --> 00:01:53,200 Speaker 1: getting bit by like an inland taipe in a snake 37 00:01:53,240 --> 00:01:55,560 Speaker 1: whose venom is supposedly one of the most toxic in 38 00:01:55,560 --> 00:01:58,320 Speaker 1: the world. Inside this, you know, terrible agonizing death in 39 00:01:58,400 --> 00:02:01,280 Speaker 1: America matter of minutes. Yeah, or any Just do a 40 00:02:01,280 --> 00:02:04,200 Speaker 1: Google image search and you'll see all number of horrible black, 41 00:02:04,400 --> 00:02:08,840 Speaker 1: gaping wounds and people with you know, limbs swollen up 42 00:02:08,880 --> 00:02:12,480 Speaker 1: like like giant balloons. Yeah, so venom, as you guys know, 43 00:02:12,639 --> 00:02:14,520 Speaker 1: it comes with a built in delivery system. It's not 44 00:02:14,600 --> 00:02:17,680 Speaker 1: just um a defensive mechanism. It tends to be used 45 00:02:17,680 --> 00:02:19,920 Speaker 1: as an offensive mechanism. You know, you think of a 46 00:02:19,960 --> 00:02:21,760 Speaker 1: snake and it has the venom, will it needs the 47 00:02:21,800 --> 00:02:24,639 Speaker 1: means to deliver it, so the fangs or how whatever 48 00:02:24,680 --> 00:02:29,160 Speaker 1: means it chooses. And so, aside from these agonizing deaths 49 00:02:29,160 --> 00:02:32,000 Speaker 1: that induces, venom is actually pretty cool And there's a 50 00:02:32,000 --> 00:02:34,679 Speaker 1: lot of interesting therapeutic research that's going on out there 51 00:02:35,160 --> 00:02:38,880 Speaker 1: in science labs right now. And why are they doing this? 52 00:02:38,919 --> 00:02:41,799 Speaker 1: Why is whenom so promising? Well, because it's full stuff 53 00:02:41,840 --> 00:02:44,320 Speaker 1: like proteins that can manage pain and treat illnesses. So 54 00:02:44,600 --> 00:02:46,800 Speaker 1: Robert and I thought we'd do a little survey of 55 00:02:46,880 --> 00:02:48,600 Speaker 1: some of the research that's going on with the world's 56 00:02:48,639 --> 00:02:52,119 Speaker 1: venomous creatures. And of course I'm kicking off with snakes. 57 00:02:53,080 --> 00:02:55,200 Speaker 1: I think I will definitely say that I've had a 58 00:02:55,240 --> 00:02:58,920 Speaker 1: turnaround with my feeling for snakes, they're just amazingly, amazingly 59 00:02:59,000 --> 00:03:03,600 Speaker 1: cool organisms. We did a whole series of articles um 60 00:03:03,680 --> 00:03:06,480 Speaker 1: for an Animal Planet show called Wild Vecon in which 61 00:03:06,639 --> 00:03:11,600 Speaker 1: we examine the therapeutic benefits of venom, snake venom in particular, 62 00:03:11,680 --> 00:03:14,919 Speaker 1: and it's pretty amazing. So let's do a quicker view 63 00:03:14,919 --> 00:03:17,360 Speaker 1: of some of the key components found in different snake venoms. 64 00:03:18,200 --> 00:03:20,040 Speaker 1: Some of the stuff that just may kill you or 65 00:03:20,200 --> 00:03:22,600 Speaker 1: cause you great pain. You have stuff like cytotoxins, and 66 00:03:22,639 --> 00:03:26,000 Speaker 1: what a citotoxin is gonna do. They're gonna cause cell death. Basically, 67 00:03:26,360 --> 00:03:30,799 Speaker 1: there's actually beginning the digestion process for the snake like 68 00:03:30,880 --> 00:03:34,200 Speaker 1: grattlesnakes for example, of cytotoxins, and then use stuff like 69 00:03:34,280 --> 00:03:37,120 Speaker 1: hemotoxins and this is this gets the blood involves and 70 00:03:37,320 --> 00:03:41,480 Speaker 1: you can cause blood clots and basically decimate the blood vessels. Um. 71 00:03:41,520 --> 00:03:47,400 Speaker 1: So a gaboon viper they have have these, isn't it? 72 00:03:48,240 --> 00:03:51,120 Speaker 1: Or a motorcycle I'm picturing like a fancy Japanese motorcycle. 73 00:03:51,440 --> 00:03:54,920 Speaker 1: Well it's also a snake, yes, yes it is. And 74 00:03:54,920 --> 00:03:56,680 Speaker 1: then you use stuff like neurotoxins and this is going 75 00:03:56,720 --> 00:03:59,800 Speaker 1: to affect the praise nervous system and do stuff like 76 00:04:00,160 --> 00:04:04,280 Speaker 1: nerve impulses and make the prey become paralyzed or um 77 00:04:04,320 --> 00:04:07,680 Speaker 1: it could just make the nervous system collapse. So a 78 00:04:07,760 --> 00:04:10,280 Speaker 1: cobra and a sea snake might have these elements. So 79 00:04:10,600 --> 00:04:16,400 Speaker 1: how is science interested in using UH venom? Any guesses, Well, 80 00:04:16,560 --> 00:04:20,520 Speaker 1: the cell death um aspect would definitely lend itself well 81 00:04:20,520 --> 00:04:23,840 Speaker 1: to fighting cancer or destroying any kind of cells that 82 00:04:24,800 --> 00:04:27,320 Speaker 1: need to get got. And that is true. And also 83 00:04:27,400 --> 00:04:32,600 Speaker 1: cobra venom contains a pretty powerful anti coagulants and these 84 00:04:32,640 --> 00:04:35,360 Speaker 1: anti coagulants are used as a blood thinner and humans. 85 00:04:35,360 --> 00:04:39,200 Speaker 1: And there's a company that actually manufactures a drub called Exanta, 86 00:04:39,360 --> 00:04:42,800 Speaker 1: and they've tested extensively in clinical trials UH with like 87 00:04:42,880 --> 00:04:47,599 Speaker 1: thousands and thousands of volunteers, and the European Union has 88 00:04:47,640 --> 00:04:51,720 Speaker 1: approved this particular drug derive from cobra venom for preventing 89 00:04:51,760 --> 00:04:54,120 Speaker 1: clots after surgery. So it's pretty cool. It's a long 90 00:04:54,160 --> 00:04:58,039 Speaker 1: way from the cobra, you know, and it's habitat um. 91 00:04:58,080 --> 00:05:00,360 Speaker 1: I have a cool use for a cobra than them 92 00:05:00,360 --> 00:05:04,440 Speaker 1: as Well's there if if you go to Thailand, you 93 00:05:04,440 --> 00:05:06,320 Speaker 1: you may occasionally see in a bar you'll see like 94 00:05:06,320 --> 00:05:10,080 Speaker 1: a fancy bottle of this amber liquid that has a 95 00:05:10,120 --> 00:05:13,520 Speaker 1: whole cobra in it. And this is a rice whiskey 96 00:05:13,560 --> 00:05:16,240 Speaker 1: that has been uh that that has been infused with 97 00:05:16,240 --> 00:05:19,479 Speaker 1: with a dead cobra, all right, and they drink it 98 00:05:19,520 --> 00:05:22,200 Speaker 1: over there apparently is like it's a very manly thank 99 00:05:22,200 --> 00:05:26,560 Speaker 1: if you I didn't, I think it's technically illegal. Um, 100 00:05:26,600 --> 00:05:29,600 Speaker 1: and I wasn't. There's so much to be floored by 101 00:05:29,640 --> 00:05:33,200 Speaker 1: over there without seeking out potentially deadly in toxicanst but 102 00:05:33,480 --> 00:05:37,160 Speaker 1: it's it's also apparently seen as an aphrodisiac. And there's 103 00:05:37,200 --> 00:05:40,480 Speaker 1: actually a really good review of it online at spirits 104 00:05:40,480 --> 00:05:44,479 Speaker 1: review dot com where he describes it quote as a 105 00:05:44,480 --> 00:05:48,760 Speaker 1: as a quote an interesting, if potentially neurotoxic whiskey unquote, 106 00:05:48,960 --> 00:05:52,200 Speaker 1: and he describes the taste as quote fishy hot taste, 107 00:05:52,520 --> 00:05:55,520 Speaker 1: almost like drinking peanut oil and alcohol with notes of 108 00:05:55,600 --> 00:06:01,000 Speaker 1: gen singh uh. And apparently it creates this this kind 109 00:06:01,000 --> 00:06:05,679 Speaker 1: of like tingling effect all over and this numbing um. 110 00:06:05,800 --> 00:06:11,159 Speaker 1: So potentially very dangerous with very little application. But if 111 00:06:11,200 --> 00:06:13,360 Speaker 1: you ever go to Thailand and you try it, be 112 00:06:13,360 --> 00:06:15,720 Speaker 1: sure to let us know don't do not try it, 113 00:06:15,760 --> 00:06:18,920 Speaker 1: because we're talking about it for legal purposes, but if 114 00:06:18,960 --> 00:06:22,640 Speaker 1: you have tried it, please please email us. Yeah, so 115 00:06:23,040 --> 00:06:25,600 Speaker 1: cobra venom is pretty popular in scientific circles because it's 116 00:06:25,640 --> 00:06:29,400 Speaker 1: also being uh investigated to see how it affects MS 117 00:06:29,480 --> 00:06:32,360 Speaker 1: or a multiple sclerosis. Uh. And you guys know that's 118 00:06:32,360 --> 00:06:35,599 Speaker 1: the chronic disease of your central nervous system. So in 119 00:06:35,640 --> 00:06:38,760 Speaker 1: patients with MS, the immune system is attacking the nerve 120 00:06:38,839 --> 00:06:42,600 Speaker 1: cells and it's stripping off these um protective insulating sheets 121 00:06:42,600 --> 00:06:46,760 Speaker 1: on the nerve cells. So cobra toxin, however, is suppressing 122 00:06:46,800 --> 00:06:49,960 Speaker 1: the immune system and animals with the disease. In fact, 123 00:06:50,000 --> 00:06:52,599 Speaker 1: early research has been sur promising that they have clinical 124 00:06:52,640 --> 00:06:55,080 Speaker 1: trials going on now to study the effects of cobra 125 00:06:55,120 --> 00:06:58,880 Speaker 1: toxin human patients with MS, which pretty neat. They've also 126 00:06:59,000 --> 00:07:02,560 Speaker 1: used as snake foundom to figure out ways to anesthetize 127 00:07:02,560 --> 00:07:05,840 Speaker 1: patients during surgery. Really disguise the limit when it comes 128 00:07:05,880 --> 00:07:08,679 Speaker 1: to snake venom. I mean, it just contains so many 129 00:07:08,880 --> 00:07:12,800 Speaker 1: different elements that could be used for potential therapeutic purposes. 130 00:07:13,160 --> 00:07:14,760 Speaker 1: But it takes a long way to go from a 131 00:07:14,880 --> 00:07:17,720 Speaker 1: raw talx into an FDA proof drug, So we'll see. 132 00:07:17,720 --> 00:07:19,840 Speaker 1: I mean, this is definitely an area to watch. It's 133 00:07:19,840 --> 00:07:22,840 Speaker 1: also interesting and that as as is the case with 134 00:07:22,840 --> 00:07:25,320 Speaker 1: with a lot of these venoms we're talking about, um, 135 00:07:25,480 --> 00:07:29,160 Speaker 1: older traditional forms of medicine. We're using these thousands of 136 00:07:29,200 --> 00:07:34,200 Speaker 1: years ago. Take ancient Indian ara vedic medicine. Um. They 137 00:07:34,480 --> 00:07:37,000 Speaker 1: and I found this really interesting. They collect the venom 138 00:07:37,040 --> 00:07:39,720 Speaker 1: like nowadays. You've probably seen a footage where they take 139 00:07:39,760 --> 00:07:42,520 Speaker 1: the snake and they stick its things over a glass 140 00:07:42,520 --> 00:07:44,760 Speaker 1: and kind of like squeeze themselves a little beaker full 141 00:07:44,760 --> 00:07:48,280 Speaker 1: of venom. Um. But apparently they take the snake, force 142 00:07:48,360 --> 00:07:50,400 Speaker 1: it to sink its things into a piece of fruit, 143 00:07:51,000 --> 00:07:53,080 Speaker 1: and the fruit would absorb the venom and then you 144 00:07:53,080 --> 00:07:55,840 Speaker 1: would ingest the fruit. Uh, if you needed to be 145 00:07:55,880 --> 00:07:59,720 Speaker 1: treated for like liver dysfunctions or eye disease or or 146 00:07:59,800 --> 00:08:04,000 Speaker 1: you know, various stuff, various illnesses. So what do you 147 00:08:04,080 --> 00:08:07,200 Speaker 1: what do you have on wasps and bees? Oh? Well, um, 148 00:08:07,360 --> 00:08:11,800 Speaker 1: wasp and bees. Wasp I find particularly fascinating. Uh you 149 00:08:11,800 --> 00:08:15,160 Speaker 1: write an article about right? Um? Well yeah, I actually 150 00:08:15,160 --> 00:08:17,280 Speaker 1: wrote how wasps work as well. That was one of 151 00:08:17,280 --> 00:08:19,960 Speaker 1: my earlier articles here at the site. So you're a 152 00:08:19,960 --> 00:08:22,560 Speaker 1: well of wasp knowledge. I really gore to respect them 153 00:08:22,600 --> 00:08:24,360 Speaker 1: like a lot of people are like, oh, wasp, and 154 00:08:24,400 --> 00:08:27,560 Speaker 1: they're like, oh, but they love bees, like oh, you know, God, 155 00:08:27,680 --> 00:08:29,720 Speaker 1: let me buy some chapstick with a bee on it 156 00:08:29,880 --> 00:08:32,200 Speaker 1: and let me dress my child like a bee for Halloween. 157 00:08:32,360 --> 00:08:34,679 Speaker 1: But wasps, it's just kill on site. The wasp are 158 00:08:34,720 --> 00:08:37,000 Speaker 1: really amazing. I mean there, I could go on a 159 00:08:37,000 --> 00:08:38,520 Speaker 1: whole tangent. But like, you know, you think you have 160 00:08:38,559 --> 00:08:40,679 Speaker 1: too many poisono spiders around your house? Are you're afraid 161 00:08:40,720 --> 00:08:44,120 Speaker 1: of like brown, reclusive and whatever? Get dirt dabbers because 162 00:08:44,120 --> 00:08:46,280 Speaker 1: dirt dabbers. Um, you know, the little the ones that 163 00:08:46,320 --> 00:08:48,520 Speaker 1: build their little nests out of mud. I think they're 164 00:08:48,559 --> 00:08:51,680 Speaker 1: called different things in different regions. But those guys eat 165 00:08:51,720 --> 00:08:54,400 Speaker 1: spiders like crazy. They'll like bring them back for their young. 166 00:08:54,720 --> 00:08:56,800 Speaker 1: Why did they bring them? Bring spiders back for their 167 00:08:56,800 --> 00:08:59,720 Speaker 1: young is key to why there's a lot of possibility 168 00:09:00,080 --> 00:09:04,600 Speaker 1: for their for their venom. Yeah, now, wasp, whether you're 169 00:09:04,600 --> 00:09:08,240 Speaker 1: talking about wasps or bees and bees or just um, 170 00:09:08,280 --> 00:09:11,960 Speaker 1: the bees evolved from from wasp. Okay, only the females 171 00:09:11,960 --> 00:09:15,640 Speaker 1: have stingers, and that's because the stinger is an ovipositor. 172 00:09:15,840 --> 00:09:19,200 Speaker 1: This is an egg laying organ that only and only 173 00:09:19,240 --> 00:09:22,160 Speaker 1: the females have it. The purpose of the ovapositor is 174 00:09:22,200 --> 00:09:26,760 Speaker 1: to lay eggs inside of another organism, so it's it's 175 00:09:26,760 --> 00:09:29,480 Speaker 1: you know, it's sharp, it sticks into another creature's body. 176 00:09:29,880 --> 00:09:33,120 Speaker 1: And the venom. The purpose of the venom would be 177 00:09:33,240 --> 00:09:38,480 Speaker 1: too incapacitate the prey, but also to um to make 178 00:09:38,559 --> 00:09:40,480 Speaker 1: changes in it to where it can be used as 179 00:09:40,520 --> 00:09:43,320 Speaker 1: a living nursery for the growing young, which will eventually 180 00:09:43,720 --> 00:09:48,920 Speaker 1: um consume it from the inside out. So interesting, yeah, 181 00:09:48,960 --> 00:09:52,320 Speaker 1: So to facilitate this, the venom inflix such symptoms as 182 00:09:52,360 --> 00:09:58,440 Speaker 1: developmental arrest, growth alteration, immune response suppression, paralysis, and behavior modification. 183 00:09:58,640 --> 00:10:01,920 Speaker 1: So it's a there's a there's a it's a complicated UM, 184 00:10:01,920 --> 00:10:04,320 Speaker 1: you know, toxin, there's a there's a lot of different 185 00:10:04,320 --> 00:10:06,520 Speaker 1: things that can go on in these in these venoms, 186 00:10:06,600 --> 00:10:09,000 Speaker 1: and that means there's a lot of potential to apply 187 00:10:09,520 --> 00:10:12,760 Speaker 1: these two UH and and turn them into into medicines 188 00:10:12,800 --> 00:10:15,199 Speaker 1: that we can use. UM. There's been a fair amount 189 00:10:15,200 --> 00:10:18,240 Speaker 1: of recent buzz over the mapping of the parasitic wasp genome, 190 00:10:18,640 --> 00:10:24,040 Speaker 1: for it's a species called Nessonium, and UH researchers think 191 00:10:24,040 --> 00:10:26,439 Speaker 1: that this holds a lot of potential in creating new medicines. 192 00:10:26,920 --> 00:10:28,640 Speaker 1: In some cases it might we might be able to 193 00:10:28,679 --> 00:10:31,480 Speaker 1: find particular venoms that we can actually use. But then 194 00:10:31,520 --> 00:10:35,280 Speaker 1: sometimes researchers can use these as leads where we observe 195 00:10:35,840 --> 00:10:40,439 Speaker 1: the the changes that a particular venom causes, and then 196 00:10:40,480 --> 00:10:42,960 Speaker 1: we can try and create something that replicates those effects. 197 00:10:44,040 --> 00:10:46,160 Speaker 1: That that's really fascinating. And as far as bees goes, 198 00:10:46,160 --> 00:10:49,280 Speaker 1: there's a whole since again everyone loves bees, but wasps 199 00:10:49,480 --> 00:10:52,480 Speaker 1: or dirty creatures. There are people that that are just 200 00:10:52,559 --> 00:10:57,319 Speaker 1: crazy about be curatives. It's they call it um apitherapy, 201 00:10:57,960 --> 00:11:00,480 Speaker 1: and this is an alternative medicine you. But there are 202 00:11:00,480 --> 00:11:02,920 Speaker 1: people that just are like, oh, you're sick, here, have 203 00:11:03,000 --> 00:11:06,080 Speaker 1: some b wax, have some honey, have some have some here, 204 00:11:06,440 --> 00:11:09,920 Speaker 1: just let some be sting and it's gonna be fine. Um. 205 00:11:09,960 --> 00:11:14,560 Speaker 1: They're they're really sold on the idea. But Western medicine 206 00:11:14,640 --> 00:11:19,760 Speaker 1: is still kind of feeling it out. Are their studies investigating, Yeah, yeah, 207 00:11:19,760 --> 00:11:23,400 Speaker 1: there are studies. It's a it's just the scientists are 208 00:11:23,440 --> 00:11:26,760 Speaker 1: not as sold on it as the as the alternative 209 00:11:26,760 --> 00:11:32,439 Speaker 1: medicine crowd um. And then there's rachmans and spiders um, 210 00:11:32,600 --> 00:11:35,400 Speaker 1: the ones that the wasp don't catch and fill what 211 00:11:35,400 --> 00:11:38,920 Speaker 1: they're young. Take scorpions for instance, most of the you know, 212 00:11:38,920 --> 00:11:40,760 Speaker 1: most people probably think of these is just the things 213 00:11:40,760 --> 00:11:43,040 Speaker 1: that you don't want in your shoes, right Like in 214 00:11:43,360 --> 00:11:46,320 Speaker 1: Mexico alone, I think each year a hundred thousand people 215 00:11:46,400 --> 00:11:51,079 Speaker 1: suffer from scorpion stings UM and uh, you know, and 216 00:11:51,160 --> 00:11:53,800 Speaker 1: then it can be pretty bad news. You can cause delirium, 217 00:11:54,040 --> 00:11:59,040 Speaker 1: intensive pain, et cetera. But Harvard researchers UM experimented with 218 00:11:59,080 --> 00:12:04,000 Speaker 1: giving my nice calatoxin from scorpion venom and they observed 219 00:12:04,120 --> 00:12:07,880 Speaker 1: eight less jawbone loss in the rats. Okay, now this 220 00:12:07,920 --> 00:12:11,160 Speaker 1: is this is how this this works. The calatoxin blocks 221 00:12:11,160 --> 00:12:14,400 Speaker 1: a protein that plays a major role in inflammation, and 222 00:12:14,440 --> 00:12:17,080 Speaker 1: when it's blocked, it also decreases the activity of a 223 00:12:17,120 --> 00:12:20,880 Speaker 1: protein UM that plays a role in stimulating bone eating 224 00:12:21,280 --> 00:12:24,920 Speaker 1: um Osteo class. So they think it could it could 225 00:12:24,920 --> 00:12:27,400 Speaker 1: have a lot of potential to you know, help help 226 00:12:27,480 --> 00:12:31,520 Speaker 1: fight things like um, you know, opteoporosis, etcetera. Right, so 227 00:12:31,600 --> 00:12:34,160 Speaker 1: all these elderly women who are you know, hopping up 228 00:12:34,160 --> 00:12:37,960 Speaker 1: on calcium venoms might instead be scorpion scorpion or two 229 00:12:38,000 --> 00:12:41,280 Speaker 1: you can wear them like like broaches, you know, UM 230 00:12:41,320 --> 00:12:45,200 Speaker 1: and this is this is a really amazing radioactive scorpion venom, 231 00:12:45,480 --> 00:12:47,959 Speaker 1: which I sounds like a set up for a comic 232 00:12:48,000 --> 00:12:51,200 Speaker 1: book hero. But and I think maybe is like the 233 00:12:51,200 --> 00:12:54,120 Speaker 1: scorpion you know comic books, right, No, no, you don't 234 00:12:54,120 --> 00:12:58,080 Speaker 1: know com but no, I think the scorpion is anyway, 235 00:12:58,160 --> 00:13:00,240 Speaker 1: But this has nothing to do with that. The venom 236 00:13:00,240 --> 00:13:05,640 Speaker 1: of the yellow Israeli scorpion shows preferential attachment too, glioma 237 00:13:05,720 --> 00:13:09,160 Speaker 1: tumor cells in the brain or spine. All right, So 238 00:13:09,240 --> 00:13:11,680 Speaker 1: scientists have figured out that they can attach a radio 239 00:13:11,920 --> 00:13:17,920 Speaker 1: radioactive iodine to an artificial version of this venom. So 240 00:13:18,240 --> 00:13:20,640 Speaker 1: the artificial version of this venom then attaches to the 241 00:13:20,679 --> 00:13:24,280 Speaker 1: tumor cell, and since it's got a little backpack of radiation, 242 00:13:24,720 --> 00:13:27,480 Speaker 1: the radiation kills the cell. So it's kind of used 243 00:13:27,480 --> 00:13:29,040 Speaker 1: it like a kind of like a trojan horse kind 244 00:13:29,040 --> 00:13:32,600 Speaker 1: of deal. Very cool. Yeah, so let's get to the water. 245 00:13:32,679 --> 00:13:35,080 Speaker 1: Then let's do it. List at the water, what do 246 00:13:35,080 --> 00:13:38,720 Speaker 1: you got? Jellyfish? Jellyfish and fish in the water. You're 247 00:13:38,720 --> 00:13:41,560 Speaker 1: gonna find venomous jellyfish and you know, plain old fish. 248 00:13:41,640 --> 00:13:44,760 Speaker 1: In fact, one pretty interesting fact I came across when 249 00:13:44,760 --> 00:13:46,959 Speaker 1: we're doing this venom research was that there are more 250 00:13:47,080 --> 00:13:50,360 Speaker 1: venomous fish than snakes, according to this two thousand six 251 00:13:50,400 --> 00:13:53,000 Speaker 1: study published in the Journal of Heredity. Well, that makes 252 00:13:53,040 --> 00:13:55,840 Speaker 1: sense because the the oceans are really the most just, 253 00:13:56,800 --> 00:13:59,240 Speaker 1: i mean, just the roughest area to try and cut 254 00:13:59,240 --> 00:14:02,320 Speaker 1: out an evolutionary ray Niche did you do it? Well? 255 00:14:02,360 --> 00:14:04,440 Speaker 1: So one of the species that they mentioned is the 256 00:14:04,440 --> 00:14:06,120 Speaker 1: lion fish. Didn't you do a blog post about their 257 00:14:06,120 --> 00:14:09,440 Speaker 1: line fishline fish is a really horrible invasive species in 258 00:14:09,480 --> 00:14:14,400 Speaker 1: the um in the Atlantic waters um. It's just most 259 00:14:14,400 --> 00:14:16,760 Speaker 1: of most of the native species aren't used to handling 260 00:14:17,000 --> 00:14:19,360 Speaker 1: the venom that these guys carry in their spine. They're 261 00:14:19,360 --> 00:14:22,160 Speaker 1: beautiful fish, and that's one of the reasons that they're 262 00:14:22,600 --> 00:14:25,600 Speaker 1: when they're like three different reasons, there are a big problem, 263 00:14:25,640 --> 00:14:27,400 Speaker 1: and one of them is that people get them for 264 00:14:27,400 --> 00:14:30,280 Speaker 1: their saltwater aquariums and then they end up losing them 265 00:14:30,360 --> 00:14:34,280 Speaker 1: or dumping them, et cetera. And now down the toilet. Yeah, yeah, 266 00:14:34,280 --> 00:14:36,720 Speaker 1: that's not good. So the animal in the water that 267 00:14:36,800 --> 00:14:39,480 Speaker 1: really captured my interest was this box jellyfish. Have ever 268 00:14:39,520 --> 00:14:41,760 Speaker 1: heard of a box jellyfish? No? Is it cute shaped? 269 00:14:43,040 --> 00:14:46,440 Speaker 1: Because I'm picturing a cube? No, it's roughly like the 270 00:14:46,480 --> 00:14:48,080 Speaker 1: size of a peanut, and it has one of the 271 00:14:48,120 --> 00:14:52,120 Speaker 1: most toxic venoms in the world. And one of the 272 00:14:52,160 --> 00:14:55,360 Speaker 1: species is called the molo kinney. And how did it 273 00:14:55,440 --> 00:14:58,120 Speaker 1: get its name, Well from a US tourist who was 274 00:14:58,200 --> 00:15:01,480 Speaker 1: killed by one in two thousand two. Up a gentleman 275 00:15:01,560 --> 00:15:04,960 Speaker 1: by the name of Robert King who is presumably mining 276 00:15:05,000 --> 00:15:07,000 Speaker 1: his own business and swimming off the coast of Australia 277 00:15:07,080 --> 00:15:10,360 Speaker 1: and Wemmo. He was stung by one of these boxed jellyfish, 278 00:15:10,400 --> 00:15:14,000 Speaker 1: the molochini, and he died. And it wasn't just any death, 279 00:15:14,040 --> 00:15:15,760 Speaker 1: but that when when you get a sting from one 280 00:15:15,760 --> 00:15:18,680 Speaker 1: of these organisms, that can lead to symptoms like you know, 281 00:15:18,760 --> 00:15:21,120 Speaker 1: shooting pains in your muscles and chests. You get some 282 00:15:21,200 --> 00:15:24,960 Speaker 1: muscle cramps in your arms, you get severe pain in 283 00:15:25,000 --> 00:15:28,160 Speaker 1: the back and in your kidneys, a burning sensation of 284 00:15:28,160 --> 00:15:30,880 Speaker 1: the skin, and face headaches. Oh and this is my 285 00:15:30,920 --> 00:15:32,880 Speaker 1: favorite one, um, as far as one of these can 286 00:15:32,880 --> 00:15:36,280 Speaker 1: be a favorite. A psychological phenomena like the feeling of 287 00:15:36,320 --> 00:15:39,720 Speaker 1: impending death does a lot of work for just one 288 00:15:39,880 --> 00:15:44,640 Speaker 1: venom by a peanut sized jellyfish. So it's gotten so 289 00:15:44,680 --> 00:15:47,120 Speaker 1: bad and people are so afraid of getting stung by 290 00:15:47,120 --> 00:15:53,840 Speaker 1: these particular jellyfish that Aussee lifeguards sometimes were penny hose. No, 291 00:15:53,960 --> 00:15:57,240 Speaker 1: I'm not kidding. The Australian lifeguards sometimes we're panyos on 292 00:15:57,240 --> 00:15:59,400 Speaker 1: their arms and legs to prevent the jellies from staying. 293 00:15:59,800 --> 00:16:03,080 Speaker 1: I guess because I just hate that. I mean, they 294 00:16:03,120 --> 00:16:05,840 Speaker 1: should feel comfortable wearing the pantyhouse anyway, they shouldn't have 295 00:16:05,920 --> 00:16:07,520 Speaker 1: to feel like they need to make an excuse about 296 00:16:07,560 --> 00:16:11,320 Speaker 1: crazy della fish. But now, really it really actually prevents 297 00:16:11,760 --> 00:16:13,920 Speaker 1: being stung. This is some of the lore that's out there, 298 00:16:13,920 --> 00:16:15,600 Speaker 1: and people do actually do it. Do they wear the 299 00:16:15,640 --> 00:16:18,000 Speaker 1: stocking over their head too, right, so they can do 300 00:16:18,040 --> 00:16:20,680 Speaker 1: a bank after you know, I'm gonna go swimming, put 301 00:16:20,680 --> 00:16:22,720 Speaker 1: on my pantios and then I'm gonna pull my stocking 302 00:16:22,720 --> 00:16:24,400 Speaker 1: over my head and go to a bank heist. I 303 00:16:24,400 --> 00:16:26,840 Speaker 1: don't know. So they've been studying this box jelly fish. 304 00:16:26,840 --> 00:16:29,280 Speaker 1: You figure out a product that could protect bathers from 305 00:16:29,360 --> 00:16:32,840 Speaker 1: being stung other than wearing pantyhose. Of course, researchers are 306 00:16:32,840 --> 00:16:35,000 Speaker 1: also the king to to find out like how venoms 307 00:16:35,000 --> 00:16:38,200 Speaker 1: have evolved in box jellies, and they're developing anti venoms 308 00:16:38,240 --> 00:16:40,200 Speaker 1: for the stings, because these are a serious problem in 309 00:16:40,240 --> 00:16:43,880 Speaker 1: Australian waters. It just seems like everything in Australia's poisonous, 310 00:16:44,400 --> 00:16:46,560 Speaker 1: except for maybe the kangaroos and the quals, but they 311 00:16:46,600 --> 00:16:48,880 Speaker 1: probably they're probably packing a stinger somewhere. We just haven't 312 00:16:48,920 --> 00:16:51,880 Speaker 1: noticed it yet. Right, that snake I haven't mentioned at 313 00:16:51,880 --> 00:16:53,800 Speaker 1: the beginning, the most toxic snake in the world, also 314 00:16:54,320 --> 00:16:56,840 Speaker 1: the native of Australia. I don't know how you guys 315 00:16:56,880 --> 00:17:02,200 Speaker 1: do it. As tell me about frogs, oh, frogs, um Well, 316 00:17:02,520 --> 00:17:08,359 Speaker 1: traditional Chinese medicine has incocorporated the frogs for thousands of years, 317 00:17:08,840 --> 00:17:11,520 Speaker 1: and modern Western medicine is just kind of catching up 318 00:17:11,520 --> 00:17:14,040 Speaker 1: with all this. So here are just a few frogs 319 00:17:14,359 --> 00:17:17,359 Speaker 1: that we think have some potential. There's the giant leaf frog. 320 00:17:18,040 --> 00:17:21,200 Speaker 1: This giant leaf frog, not leap frog. Not leap frog. 321 00:17:22,480 --> 00:17:26,040 Speaker 1: That's that's the different thing entirely. But it has peptides, 322 00:17:26,359 --> 00:17:29,240 Speaker 1: and it's the venom that can reduce blood pressure by 323 00:17:29,880 --> 00:17:33,439 Speaker 1: in small doses under lab conditions, So don't don't go 324 00:17:33,600 --> 00:17:36,399 Speaker 1: buying them on eBay and then sticking them to your body. 325 00:17:36,960 --> 00:17:40,280 Speaker 1: The same frog also produces a peptide that stops blood 326 00:17:40,280 --> 00:17:42,720 Speaker 1: from clotting, and they think this might be useful to 327 00:17:42,840 --> 00:17:46,880 Speaker 1: fight deep vein thrombosis. This is the condition that you're 328 00:17:46,880 --> 00:17:49,440 Speaker 1: supposed to be wary of if you're taking any long 329 00:17:49,600 --> 00:17:52,760 Speaker 1: flights in like economy. Oh yeah, that's why you're supposed 330 00:17:52,760 --> 00:17:54,639 Speaker 1: to walk around. Yeah, And this is also why if 331 00:17:54,680 --> 00:17:56,560 Speaker 1: you've taken any long flights recently and you notice the 332 00:17:56,560 --> 00:17:58,960 Speaker 1: stewardess is handing out frogs at the end of the flight, 333 00:17:59,400 --> 00:18:03,400 Speaker 1: that's what this is about. Um all right. Then there's 334 00:18:03,440 --> 00:18:06,760 Speaker 1: the African running frog, and this one actually doesn't have 335 00:18:06,760 --> 00:18:11,879 Speaker 1: any medical significance significance, but since it uses a venom 336 00:18:12,160 --> 00:18:15,439 Speaker 1: to kill insects for prey, they think it might be 337 00:18:15,520 --> 00:18:19,919 Speaker 1: useful in um in like coating crops to keep pests away. 338 00:18:20,240 --> 00:18:23,399 Speaker 1: And also the wasps that I entered and mentioned earlier, 339 00:18:23,440 --> 00:18:27,240 Speaker 1: the the parasitic wasps, They think that would also might 340 00:18:27,240 --> 00:18:32,200 Speaker 1: have a lot of potential as a pesticide enemy uses pesticide. 341 00:18:32,240 --> 00:18:36,000 Speaker 1: Interesting back to frogs, though, there's the Australian tree frog, 342 00:18:36,200 --> 00:18:40,800 Speaker 1: which is shown some um some success in the fighting 343 00:18:40,800 --> 00:18:44,119 Speaker 1: conditions of that are resistant to antibiotics, and this is 344 00:18:44,200 --> 00:18:49,480 Speaker 1: because the venom um embeds in the membrane of the 345 00:18:49,480 --> 00:18:53,080 Speaker 1: bacteria and burst the cell and they can't really become 346 00:18:53,119 --> 00:18:56,600 Speaker 1: immune to that. And then there's the North American pond 347 00:18:56,640 --> 00:19:00,080 Speaker 1: frog and they found the molecules in this particular have 348 00:19:00,080 --> 00:19:02,840 Speaker 1: been a stimulate or inhibit the growth of cancer tumors. 349 00:19:03,320 --> 00:19:05,439 Speaker 1: So there's some research going into that and seeing what 350 00:19:05,640 --> 00:19:09,080 Speaker 1: applications that might have in fighting cancer. So it seems 351 00:19:09,119 --> 00:19:12,480 Speaker 1: like frogs in in addition to coding your you know, 352 00:19:12,560 --> 00:19:16,040 Speaker 1: poisoned darts to a shoot out of your blowguns, you know, 353 00:19:16,080 --> 00:19:19,720 Speaker 1: they have a lot of medical possibilities as well. Yeah, 354 00:19:19,760 --> 00:19:21,600 Speaker 1: it definitely seems that there's a lot of venom research 355 00:19:21,680 --> 00:19:25,439 Speaker 1: that could be used for therapeutic purposes for people with 356 00:19:25,520 --> 00:19:27,560 Speaker 1: heart problems, I mean that keeps on coming up, and 357 00:19:27,560 --> 00:19:30,520 Speaker 1: people with blood pressure and uh and I don't think 358 00:19:30,560 --> 00:19:32,439 Speaker 1: they've really looked into this, but I think energy drinks 359 00:19:32,440 --> 00:19:35,119 Speaker 1: could be a big, big area of development. You know, 360 00:19:35,720 --> 00:19:37,639 Speaker 1: the one called venom, I think there's one. There's one 361 00:19:37,680 --> 00:19:39,480 Speaker 1: called venom, but I didn't look it up, so I 362 00:19:39,520 --> 00:19:42,000 Speaker 1: don't know. But it actually has like scorpion venom or 363 00:19:42,080 --> 00:19:43,800 Speaker 1: but you could have the you could have a whole line, 364 00:19:43,800 --> 00:19:45,760 Speaker 1: like each one has a different cartoon animal on it. 365 00:19:45,800 --> 00:19:48,240 Speaker 1: Like one has a wasp and then there's like a scorpion. 366 00:19:48,320 --> 00:19:50,879 Speaker 1: It's like it's like using its close to like lift weights, 367 00:19:51,000 --> 00:19:54,480 Speaker 1: you know, marketed towards each one could be a specific 368 00:19:54,520 --> 00:19:58,720 Speaker 1: animal marketed towards it a particular like extreme sport or 369 00:19:58,800 --> 00:20:02,399 Speaker 1: high energy, macho caffeine kind of a thing. All right, 370 00:20:02,440 --> 00:20:05,119 Speaker 1: So let's go from frogs to our last animal, and 371 00:20:05,400 --> 00:20:12,480 Speaker 1: our last animals a mammal, the platypus. We've covered reptiles, spiders, jellyfish, snakes, frogs, 372 00:20:12,480 --> 00:20:14,920 Speaker 1: but what about mammals. I don't I don't tend to 373 00:20:14,960 --> 00:20:18,359 Speaker 1: think of venomous mammals to you know, and like a 374 00:20:18,440 --> 00:20:21,840 Speaker 1: venomous ape. Yeah, I love the idea of enomous eate. 375 00:20:21,920 --> 00:20:25,439 Speaker 1: But I completely made it up. And that's the thing. 376 00:20:25,440 --> 00:20:28,040 Speaker 1: The platypus really sounds like a made up animal. It 377 00:20:28,080 --> 00:20:30,159 Speaker 1: really does. In fact, they thought it was made up. 378 00:20:30,480 --> 00:20:33,560 Speaker 1: There was a platypus that was sent to the Brits 379 00:20:33,800 --> 00:20:37,200 Speaker 1: um a while a while back, you know, eons ago, 380 00:20:37,960 --> 00:20:39,840 Speaker 1: and the Brits didn't believe that it was and so they, 381 00:20:39,960 --> 00:20:43,200 Speaker 1: you know, they thought it was like, yeah, they thought 382 00:20:43,200 --> 00:20:45,680 Speaker 1: it was a fake animal. Because apparently Chinese folks have 383 00:20:45,800 --> 00:20:47,760 Speaker 1: been known to do this. They made up an animal 384 00:20:47,800 --> 00:20:50,639 Speaker 1: called an Eastern mermaid. Yeah, it was like the monkey 385 00:20:50,720 --> 00:20:53,240 Speaker 1: and the fish parts, right, so they thought that this 386 00:20:53,320 --> 00:20:57,200 Speaker 1: platypus was a similar thing. Yeah, kind of Coney Island 387 00:20:57,200 --> 00:21:00,840 Speaker 1: freak show kind of stuff. Well, so platypuss guys probably 388 00:21:00,840 --> 00:21:03,439 Speaker 1: remember it's it's the duck build furry creature. It's this 389 00:21:04,000 --> 00:21:06,760 Speaker 1: weird combo of a bird and a reptile and a mammal, 390 00:21:06,800 --> 00:21:09,520 Speaker 1: but it actually is a mammal. They're like these odd 391 00:21:09,520 --> 00:21:13,800 Speaker 1: balls of the animal kingdom. But the most interesting thing is, well, 392 00:21:14,359 --> 00:21:16,800 Speaker 1: one of the most interesting things in platypus lore is 393 00:21:16,840 --> 00:21:18,920 Speaker 1: that the males have these venomous spurs on the back 394 00:21:18,960 --> 00:21:22,040 Speaker 1: of each of their hind legs. My females have the 395 00:21:22,080 --> 00:21:24,800 Speaker 1: spurs too, but they fall off before adulthood. The only 396 00:21:24,800 --> 00:21:26,919 Speaker 1: thing that researchers can think of for the for the 397 00:21:26,960 --> 00:21:30,399 Speaker 1: spurs is that they're they're used when males are duking 398 00:21:30,440 --> 00:21:33,679 Speaker 1: it out for a mate. So nobody's died from a 399 00:21:33,720 --> 00:21:36,280 Speaker 1: platypus poisoning per se. In fact, we have an article 400 00:21:36,720 --> 00:21:39,320 Speaker 1: of that same name. Could a platypus poison me? By 401 00:21:39,520 --> 00:21:41,479 Speaker 1: by Christen Conger. I believe you should check it up. 402 00:21:42,680 --> 00:21:44,800 Speaker 1: So there are no known human fatalities, but surely some 403 00:21:44,840 --> 00:21:48,880 Speaker 1: dogs have dined. And in case you're thinking that platypus 404 00:21:48,960 --> 00:21:52,800 Speaker 1: venom is is, you know nothing in the venom kingdom. 405 00:21:52,800 --> 00:21:55,520 Speaker 1: In humans, the pain caused by platypus venom isn't relieved 406 00:21:55,520 --> 00:21:59,720 Speaker 1: by morphine, so that's pretty pretty scruciating. So Assie researchers 407 00:22:00,040 --> 00:22:02,880 Speaker 1: again comes down to Australia. They're looking into how platypus 408 00:22:03,000 --> 00:22:04,960 Speaker 1: venom could be used for pain management. There's also a 409 00:22:04,960 --> 00:22:08,600 Speaker 1: lot of pain management themes going through this venom applications. 410 00:22:09,720 --> 00:22:12,120 Speaker 1: They're also really interested in the platypus just generally because 411 00:22:12,160 --> 00:22:15,159 Speaker 1: it's the oldest surviving branch of all mammals living today 412 00:22:15,920 --> 00:22:18,919 Speaker 1: and they in addition they've they've undertaken a draft genome 413 00:22:18,920 --> 00:22:22,080 Speaker 1: analysis of the duck build platypus. So far, we've seen 414 00:22:22,119 --> 00:22:25,439 Speaker 1: platypus venom show positive results in reducing great amounts of 415 00:22:25,440 --> 00:22:29,919 Speaker 1: pain and that's about it. So it seems like platypus 416 00:22:30,080 --> 00:22:32,600 Speaker 1: venom researches is wide open if any of you guys 417 00:22:32,600 --> 00:22:34,640 Speaker 1: are looking for an area research to get to get 418 00:22:34,640 --> 00:22:37,240 Speaker 1: going in, and it sounds like a place to go 419 00:22:37,280 --> 00:22:39,760 Speaker 1: with Australia for any of these venom research places. Just 420 00:22:39,800 --> 00:22:42,560 Speaker 1: make sure you don't get a run in your pantyhouse. Sorry, 421 00:22:42,600 --> 00:22:45,760 Speaker 1: that could be the last mistake you make. So if 422 00:22:45,800 --> 00:22:48,080 Speaker 1: you've been bitten by a venomous animal or used one 423 00:22:48,080 --> 00:22:50,840 Speaker 1: of the medicines we mentioned, or drank the cobra drink 424 00:22:50,840 --> 00:22:54,400 Speaker 1: in Thailand, yes do do email us if you've actually 425 00:22:54,440 --> 00:22:57,960 Speaker 1: consumed that beverage because I'm very interested here at tales. Yeah, 426 00:22:58,040 --> 00:23:00,000 Speaker 1: send us an email at science stuff at how stuff 427 00:23:00,000 --> 00:23:01,679 Speaker 1: works dot com. Or you can check out some of 428 00:23:01,680 --> 00:23:05,040 Speaker 1: our related content like do jellyfish have the deadliest venom 429 00:23:05,040 --> 00:23:07,919 Speaker 1: in the world? Or Christian Congress fine article that we 430 00:23:08,000 --> 00:23:11,240 Speaker 1: just mentioned on the Platypus, or visit the blogs. That's 431 00:23:11,240 --> 00:23:20,879 Speaker 1: all we got. Thanks for listening. For more on this 432 00:23:21,080 --> 00:23:24,560 Speaker 1: and thousands of other topics, visit how stuff works dot com. 433 00:23:24,840 --> 00:23:27,639 Speaker 1: Want more how stuff works, check out our blogs on 434 00:23:27,680 --> 00:23:29,440 Speaker 1: the house stuff works dot com home page