1 00:00:10,840 --> 00:00:14,520 Speaker 1: Welcome to the Therapy for Black Girls Podcast, a weekly 2 00:00:14,560 --> 00:00:19,320 Speaker 1: conversation about mental health, personal development, and all the small 3 00:00:19,360 --> 00:00:22,520 Speaker 1: decisions we can make to become the best possible versions 4 00:00:22,520 --> 00:00:26,640 Speaker 1: of ourselves. I'm your host, doctor Joy hard and Bradford, 5 00:00:27,000 --> 00:00:32,080 Speaker 1: a licensed psychologist in Atlanta, Georgia. For more information or 6 00:00:32,200 --> 00:00:35,600 Speaker 1: to find a therapist in your area, visit our website 7 00:00:35,720 --> 00:00:39,440 Speaker 1: at Therapy for Blackgirls dot com. While I hope you 8 00:00:39,479 --> 00:00:43,479 Speaker 1: love listening to and learning from the podcast, it is 9 00:00:43,520 --> 00:00:46,440 Speaker 1: not meant to be a substitute for a relationship with 10 00:00:46,479 --> 00:00:57,480 Speaker 1: a licensed mental health professional. Hey, y'all, thanks so much 11 00:00:57,480 --> 00:00:59,640 Speaker 1: for joining us for session four twenty six of the 12 00:00:59,640 --> 00:01:02,840 Speaker 1: Therapy for Black Girls Podcast. We'll get right into our 13 00:01:02,880 --> 00:01:15,840 Speaker 1: conversation after a word from our sponsors. Today, doctor Fatima 14 00:01:15,920 --> 00:01:20,039 Speaker 1: Cody Stanford joins us for a compassionate conversation about weight, 15 00:01:20,560 --> 00:01:25,119 Speaker 1: health and healing. We're exploring why obesity should be understood 16 00:01:25,120 --> 00:01:28,679 Speaker 1: as a chronic disease and not a moral failing, and 17 00:01:28,760 --> 00:01:32,440 Speaker 1: discussing new treatment options like GLP one medications that are 18 00:01:32,520 --> 00:01:37,640 Speaker 1: changing lives. Doctor Stanford brings both scientific expertise and deep 19 00:01:37,680 --> 00:01:42,280 Speaker 1: empathy to this work. She's an obesity medicine physician scientist 20 00:01:42,480 --> 00:01:46,880 Speaker 1: at Massachusetts General Hospital and Harvard Medical School. What makes 21 00:01:46,920 --> 00:01:49,919 Speaker 1: our perspective so valuable is that she understands the unique 22 00:01:50,000 --> 00:01:53,800 Speaker 1: experiences of Black women navigating weight and health in a 23 00:01:53,840 --> 00:01:57,040 Speaker 1: world that often judges us harshly as one of the 24 00:01:57,040 --> 00:02:00,400 Speaker 1: few black women leading research in this fields. Please how 25 00:02:00,480 --> 00:02:04,680 Speaker 1: chronic stress, systemic barriers, and generational trauma show up in 26 00:02:04,720 --> 00:02:08,359 Speaker 1: our bodies, and ways that traditional medicine has often overlooked. 27 00:02:09,200 --> 00:02:13,360 Speaker 1: During our conversation, we talk about the science behind weight regulation, 28 00:02:14,120 --> 00:02:17,680 Speaker 1: how new medications actually work, and why it's time to 29 00:02:17,720 --> 00:02:22,200 Speaker 1: move beyond VMI as the only measure of health. Most importantly, 30 00:02:22,600 --> 00:02:25,520 Speaker 1: doctor Stamford reminds us that seeking help for weight related 31 00:02:25,520 --> 00:02:28,600 Speaker 1: health concerns isn't giving up or taking the easy way out. 32 00:02:29,040 --> 00:02:31,480 Speaker 1: Is taking care of yourself with the same compassion you'd 33 00:02:31,480 --> 00:02:34,760 Speaker 1: show a loved one. If something resonates with you while 34 00:02:34,840 --> 00:02:38,400 Speaker 1: enjoying our conversation, please share with us on social media 35 00:02:38,520 --> 00:02:42,680 Speaker 1: using the hashtag TVG in session, or join us over 36 00:02:42,720 --> 00:02:45,480 Speaker 1: in our Patreon channel To talk more about the episode. 37 00:02:45,760 --> 00:02:48,480 Speaker 1: You can join us at community dot therapy for Blackgirls 38 00:02:48,480 --> 00:02:55,359 Speaker 1: dot com. Here's our conversation. Thank you so much for 39 00:02:55,440 --> 00:02:57,440 Speaker 1: joining us today, doctor Fatima. 40 00:02:57,480 --> 00:02:59,120 Speaker 2: Well, it's a delight to be here. 41 00:02:59,320 --> 00:03:02,240 Speaker 1: Thank you. So you have done so much incredible work 42 00:03:02,280 --> 00:03:06,040 Speaker 1: around obesity, medicine, health disparity. You know a lot of 43 00:03:06,040 --> 00:03:09,000 Speaker 1: your work in your clinical research has been around why 44 00:03:09,040 --> 00:03:12,320 Speaker 1: obesity really should be classified as a chronic health condition. 45 00:03:12,760 --> 00:03:14,760 Speaker 1: Can you say more about why you think that shift 46 00:03:14,800 --> 00:03:15,440 Speaker 1: needs to happen? 47 00:03:15,680 --> 00:03:17,760 Speaker 2: Absolutely, and I'm actually going to change it from being 48 00:03:17,760 --> 00:03:20,720 Speaker 2: a condition to a disease specifically, and I'm going to 49 00:03:20,800 --> 00:03:23,960 Speaker 2: tell you why a disease is opposed to condition. So 50 00:03:24,000 --> 00:03:27,520 Speaker 2: when it's classified as a disease, we actually treat it 51 00:03:27,560 --> 00:03:31,520 Speaker 2: with the wherewithal that it needs. So when it's a disease, 52 00:03:31,639 --> 00:03:35,960 Speaker 2: we have different forms of therapy from lifestyle to medication 53 00:03:36,160 --> 00:03:39,560 Speaker 2: to surgical interventions that we might utilize to treat it. 54 00:03:40,080 --> 00:03:43,360 Speaker 2: And we actually have those full gamut of things that 55 00:03:43,400 --> 00:03:47,000 Speaker 2: we can actually use to treat obesity. So let's talk 56 00:03:47,040 --> 00:03:49,880 Speaker 2: about different things. We have bariatric surgery or what we 57 00:03:49,920 --> 00:03:53,040 Speaker 2: call metabolic and bearatric surgery that treat it for patients 58 00:03:53,040 --> 00:03:57,720 Speaker 2: that have the most severe disease, process pharmacotherapy for those 59 00:03:57,760 --> 00:04:00,440 Speaker 2: with kind of moderate disease, and then lifestyle forms of 60 00:04:00,520 --> 00:04:04,680 Speaker 2: therapy which may fall in the diet, physical activity, and 61 00:04:04,720 --> 00:04:07,800 Speaker 2: behavioral strategies which may be working with our psychologists and 62 00:04:07,800 --> 00:04:10,400 Speaker 2: psychiatrists and things of that sort. And so when we 63 00:04:10,480 --> 00:04:12,920 Speaker 2: recognize it for the disease that it is, and we 64 00:04:12,920 --> 00:04:14,760 Speaker 2: can get into that a little bit in terms of 65 00:04:14,840 --> 00:04:18,080 Speaker 2: talking about its origin points, which are in the brain 66 00:04:18,240 --> 00:04:20,799 Speaker 2: and the atapost tissue out of post is a fancy 67 00:04:20,839 --> 00:04:23,479 Speaker 2: word for fat, but that is actually an organ and 68 00:04:23,480 --> 00:04:27,320 Speaker 2: people don't realize that that is a metabolically active organ 69 00:04:27,880 --> 00:04:30,880 Speaker 2: that has targets. And so when we can target these 70 00:04:31,920 --> 00:04:35,080 Speaker 2: organs within our body, the brain, the fat mass, we 71 00:04:35,120 --> 00:04:37,240 Speaker 2: can actually treat it for the disease that it is 72 00:04:37,400 --> 00:04:39,680 Speaker 2: and give it the wherewithal that it actually needs. 73 00:04:40,960 --> 00:04:43,599 Speaker 1: So, Asima, I am not a physician, so I feel 74 00:04:43,680 --> 00:04:46,160 Speaker 1: like some of these things I will definitely not understand, 75 00:04:46,200 --> 00:04:49,120 Speaker 1: but I got you. I do want to understand, Like 76 00:04:49,400 --> 00:04:52,520 Speaker 1: why has this been missed in the field, Like why 77 00:04:52,520 --> 00:04:55,680 Speaker 1: are we just now kind of understanding obesity as a 78 00:04:55,720 --> 00:04:58,320 Speaker 1: condition of our disease of the brain in fat as 79 00:04:58,360 --> 00:05:01,040 Speaker 1: opposed to like a wheel pop kind of being. 80 00:05:01,839 --> 00:05:06,600 Speaker 2: I think it comes down to it being a visual disease, right. 81 00:05:06,760 --> 00:05:09,680 Speaker 2: We judge the book by its cover. We look at 82 00:05:09,720 --> 00:05:13,839 Speaker 2: a person. If someone happens to carry more excess weight, 83 00:05:14,040 --> 00:05:16,840 Speaker 2: we assumed that they just did something wrong, right, they 84 00:05:16,839 --> 00:05:19,839 Speaker 2: didn't get up and exercise this morning, or they ate 85 00:05:19,880 --> 00:05:22,440 Speaker 2: too much, they didn't push away from the table, so 86 00:05:22,480 --> 00:05:26,120 Speaker 2: we assume that it's their fault, right, that they caused 87 00:05:26,200 --> 00:05:30,480 Speaker 2: this for themselves. Most diseases that people have aren't ones 88 00:05:30,520 --> 00:05:34,040 Speaker 2: that are visual in nature. You can't see if someone's 89 00:05:34,080 --> 00:05:38,159 Speaker 2: blood pressure is high, right. You can't necessarily see if 90 00:05:38,160 --> 00:05:42,400 Speaker 2: someone has diabetes unless they've developed indoor and damage from 91 00:05:42,400 --> 00:05:45,120 Speaker 2: the diabetes. Maybe they've lost some of their limbs, maybe 92 00:05:45,120 --> 00:05:48,400 Speaker 2: they developed blindness, maybe they've developed kidney disease and are 93 00:05:48,400 --> 00:05:51,880 Speaker 2: having to go to dialysis or something. Similarly, with some 94 00:05:51,920 --> 00:05:54,640 Speaker 2: of the types of cancers, you don't necessarily see that 95 00:05:54,680 --> 00:05:57,000 Speaker 2: they have cancer unless they've started to lose their hair 96 00:05:57,120 --> 00:05:59,120 Speaker 2: or things of that sort. You don't really know that 97 00:05:59,200 --> 00:06:03,120 Speaker 2: someone has cancer. Most things you don't really know unless 98 00:06:03,200 --> 00:06:05,640 Speaker 2: you're the doctor and you have the patient chart. And 99 00:06:05,680 --> 00:06:08,000 Speaker 2: the chart isn't usually a physical piece of paper any more, 100 00:06:08,080 --> 00:06:10,400 Speaker 2: rights on a computer and I can read it and 101 00:06:10,440 --> 00:06:12,600 Speaker 2: I say, oh, well, you have this, you have asthma, 102 00:06:12,720 --> 00:06:15,200 Speaker 2: or you have this or you know, these diagnoses that 103 00:06:15,240 --> 00:06:20,040 Speaker 2: you can actually read. But unfortunately, obesity is very visual, 104 00:06:20,360 --> 00:06:23,760 Speaker 2: and so we as humans we start to judge the 105 00:06:23,760 --> 00:06:25,920 Speaker 2: book by its cover, and we start really early in 106 00:06:25,960 --> 00:06:30,920 Speaker 2: life we actually start to demonstrate signs of bias towards 107 00:06:30,960 --> 00:06:34,160 Speaker 2: individuals that carry excess weight. I'm going to tell you 108 00:06:34,200 --> 00:06:38,800 Speaker 2: the age we start to really judge people. Three years old. 109 00:06:39,080 --> 00:06:41,240 Speaker 2: That's when we really start to judge people. So it 110 00:06:41,320 --> 00:06:46,880 Speaker 2: starts on the playground, it starts in preschools. It's when 111 00:06:46,920 --> 00:06:51,159 Speaker 2: we say, that person is larger than me, and so 112 00:06:51,880 --> 00:06:55,839 Speaker 2: I'm going to hooke fun at that person and assume 113 00:06:55,960 --> 00:07:00,599 Speaker 2: that they did something wrong. And we are getting those 114 00:07:00,640 --> 00:07:03,880 Speaker 2: messages from the people around us, the adults around us 115 00:07:03,920 --> 00:07:07,800 Speaker 2: that are saying, oh, there's something wrong with that kid, 116 00:07:08,480 --> 00:07:11,760 Speaker 2: there's something that's not right. And you can imagine that 117 00:07:11,840 --> 00:07:14,760 Speaker 2: as we get older, we just begin to do more 118 00:07:14,800 --> 00:07:18,040 Speaker 2: and more of that. Those persons that happen to carry 119 00:07:18,080 --> 00:07:23,120 Speaker 2: more weight become the laughing stock. We turn it into comedy. 120 00:07:23,240 --> 00:07:27,280 Speaker 2: It's an acceptable form of laughter that we have. It's 121 00:07:27,320 --> 00:07:31,240 Speaker 2: no longer acceptable to do that towards someone because of 122 00:07:31,320 --> 00:07:36,200 Speaker 2: their race or their ethnic background, or for other reasons. 123 00:07:36,280 --> 00:07:40,200 Speaker 2: But if someone happens to be larger in size, it's acceptable, 124 00:07:40,960 --> 00:07:45,040 Speaker 2: and we are just given a pass to talk about 125 00:07:45,080 --> 00:07:47,160 Speaker 2: them because of their size. And so, because of all 126 00:07:47,200 --> 00:07:51,960 Speaker 2: of these things, people, and I'm going to put doctors 127 00:07:52,360 --> 00:07:59,000 Speaker 2: on the chopping block here, doctors, nurses, exercise physiologists, physical 128 00:07:59,040 --> 00:08:03,960 Speaker 2: therapists didn't take the time to really learn the pathophysiology 129 00:08:04,000 --> 00:08:07,440 Speaker 2: about the disease because they too assumed that it was 130 00:08:07,520 --> 00:08:11,160 Speaker 2: just a matter of eating less and exercising more. 131 00:08:11,560 --> 00:08:13,640 Speaker 1: So, can you talk a little bit more about, like 132 00:08:13,680 --> 00:08:16,960 Speaker 1: some of the science behind why OBCD should now be 133 00:08:16,960 --> 00:08:19,600 Speaker 1: classified as a disease, what is actually happening in the 134 00:08:19,600 --> 00:08:20,280 Speaker 1: brain and in. 135 00:08:20,200 --> 00:08:23,280 Speaker 2: The ved Absolutely, I'm so glad you've asked me to 136 00:08:23,360 --> 00:08:28,240 Speaker 2: do that. So there's two really pathways around the brain 137 00:08:28,560 --> 00:08:31,040 Speaker 2: that tell us how much to eat and how much 138 00:08:31,120 --> 00:08:33,720 Speaker 2: to store. So there's a particular part of the brain 139 00:08:33,840 --> 00:08:37,400 Speaker 2: called the hypothalamus. It's a really small part of the brain, 140 00:08:37,800 --> 00:08:43,280 Speaker 2: but there's two pathways, and one pathway is our anorexigenic pathway. 141 00:08:43,320 --> 00:08:45,760 Speaker 2: You know, when we hear anorexia, people are told not 142 00:08:45,920 --> 00:08:48,920 Speaker 2: to eat right or told not to store fat. Mask 143 00:08:49,559 --> 00:08:51,880 Speaker 2: and that part of the brain is the fancy word 144 00:08:51,880 --> 00:08:53,600 Speaker 2: I'm going to throw out there, don't worry about it. 145 00:08:53,600 --> 00:08:56,600 Speaker 2: It's called the palm sea or the propium milaniportant pathway. 146 00:08:56,600 --> 00:08:59,040 Speaker 2: And so if we travel down or we signaled out 147 00:08:59,120 --> 00:09:01,440 Speaker 2: down that pathway, you can imagine we're going to be 148 00:09:01,600 --> 00:09:05,400 Speaker 2: leaner in appearance. Right, We're gonna store very little fat mass. 149 00:09:06,040 --> 00:09:08,560 Speaker 2: For those people that travel down that pathway, they have 150 00:09:08,679 --> 00:09:12,560 Speaker 2: high levels of something called B D and F which 151 00:09:12,600 --> 00:09:16,599 Speaker 2: stands for a brain derived neurotropic factor. So they have 152 00:09:16,679 --> 00:09:19,600 Speaker 2: high levels of that, they have lean appearance. Okay, So 153 00:09:19,600 --> 00:09:24,200 Speaker 2: they signal down that anal rexogenic pathway. Now I exclusively 154 00:09:24,240 --> 00:09:27,400 Speaker 2: treat patients with obesity, and they don't signal so well 155 00:09:27,440 --> 00:09:31,080 Speaker 2: down that pathway. They signal down a different pathway called 156 00:09:31,120 --> 00:09:34,920 Speaker 2: the A g r P pathway, which stands for the 157 00:09:35,000 --> 00:09:40,240 Speaker 2: agoty related Peptie pathway. Now we talk about anal rexogenic, 158 00:09:40,800 --> 00:09:44,920 Speaker 2: there is the opposite of that, which is called orexogenic orexigenic. 159 00:09:45,000 --> 00:09:48,120 Speaker 2: You express more fat mass and you have low levels 160 00:09:48,200 --> 00:09:51,040 Speaker 2: of BDNF. Okay, So when you have that, you are 161 00:09:51,080 --> 00:09:54,240 Speaker 2: stimulated to eat and you're stimulated to store more fat mass. 162 00:09:54,760 --> 00:09:57,120 Speaker 2: So that's what's going on in the brain. Okay, so 163 00:09:57,280 --> 00:10:00,599 Speaker 2: that's the brain piece of it now talked about is 164 00:10:00,640 --> 00:10:05,320 Speaker 2: a metabolically active organ right, So it actually is metabolically active. 165 00:10:06,080 --> 00:10:09,559 Speaker 2: And when it's being metabolically activated, if I'm stimulating that 166 00:10:09,760 --> 00:10:13,079 Speaker 2: anorexogenic pathway, you can imagine I'm not storing as much 167 00:10:13,120 --> 00:10:15,960 Speaker 2: fat mass. But if I'm going down the other fat pathway, 168 00:10:16,280 --> 00:10:19,320 Speaker 2: I'm storing more fat mass. And there's things in our 169 00:10:19,440 --> 00:10:23,160 Speaker 2: environment that can cause us to store more or less. Right, 170 00:10:23,240 --> 00:10:26,679 Speaker 2: So if we have more stress in our bodies from 171 00:10:26,880 --> 00:10:30,880 Speaker 2: external stress or stress orders, whether it be chronic stress, 172 00:10:31,440 --> 00:10:34,320 Speaker 2: you can imagine that I'm going to store more fat 173 00:10:34,440 --> 00:10:39,640 Speaker 2: mass and actually activate more of that old rexogenic pathway. 174 00:10:40,640 --> 00:10:43,400 Speaker 2: And that's really important for us to note. So I 175 00:10:43,480 --> 00:10:46,000 Speaker 2: think it's really important, particularly as a black woman who's 176 00:10:46,120 --> 00:10:49,280 Speaker 2: drawn to this, to recognize that chronic stress and stress 177 00:10:49,480 --> 00:10:53,040 Speaker 2: ors can activate that pathway. So let's take us back 178 00:10:53,080 --> 00:10:55,800 Speaker 2: to something that all of us remember and that all 179 00:10:55,880 --> 00:10:58,400 Speaker 2: of us were affected by, and that was COVID nineteen. 180 00:10:59,280 --> 00:11:02,679 Speaker 2: And so during COVID nineteen, regardless of who you were, 181 00:11:02,760 --> 00:11:05,360 Speaker 2: where you were, I think we can all agree that 182 00:11:05,440 --> 00:11:10,079 Speaker 2: we underwent stress. Some of us had more or less stress. 183 00:11:10,160 --> 00:11:13,559 Speaker 2: But I think that we universally experienced stress, and so 184 00:11:13,720 --> 00:11:17,280 Speaker 2: during that time we may have noticed some weight changes 185 00:11:17,440 --> 00:11:20,000 Speaker 2: during that time that we can't maybe account for. Because 186 00:11:20,040 --> 00:11:22,199 Speaker 2: what was very interesting also is that there was an 187 00:11:22,320 --> 00:11:26,080 Speaker 2: increase in physical activity and sometimes even healthier eating because 188 00:11:26,080 --> 00:11:28,559 Speaker 2: a lot of us were at home. We weren't going 189 00:11:28,640 --> 00:11:30,280 Speaker 2: out to eat, we weren't doing all of these things. 190 00:11:30,320 --> 00:11:33,520 Speaker 2: So what was it? What was the universal thing that 191 00:11:33,760 --> 00:11:38,200 Speaker 2: was across all of us. We had an increase in stress, 192 00:11:38,840 --> 00:11:41,080 Speaker 2: and we had an increase of stress. We have an 193 00:11:41,200 --> 00:11:44,800 Speaker 2: increase in storage of ada posts. What is ada posts? 194 00:11:45,240 --> 00:11:49,120 Speaker 2: That mass because our body thinks something bad is happening, 195 00:11:49,160 --> 00:11:51,480 Speaker 2: and something bad was happening, it was a whole pandemic, 196 00:11:51,960 --> 00:11:54,480 Speaker 2: and it thinks it needs to store to protect us 197 00:11:55,120 --> 00:11:57,800 Speaker 2: from what else is coming. So hopefully that helps us 198 00:11:57,920 --> 00:12:00,960 Speaker 2: understand a little bit about this kind of disease process. 199 00:12:01,000 --> 00:12:02,920 Speaker 2: It gets more and more complicated from that, and we 200 00:12:02,960 --> 00:12:05,760 Speaker 2: can go down different pathways and other things. But that's 201 00:12:05,800 --> 00:12:09,240 Speaker 2: some of the basics surrounding why obesity is in ded 202 00:12:09,280 --> 00:12:10,280 Speaker 2: a disease process. 203 00:12:11,440 --> 00:12:13,760 Speaker 1: Thank you so much for that explanation. That is very helpful. 204 00:12:13,760 --> 00:12:14,439 Speaker 2: I appreciate it. 205 00:12:14,679 --> 00:12:16,839 Speaker 1: Yeah, so you know something else I definitely want to 206 00:12:16,880 --> 00:12:20,000 Speaker 1: talk with you about. Is the rise in GLP ones 207 00:12:20,080 --> 00:12:23,200 Speaker 1: we are seeing lots more attention there medications like ozimpic 208 00:12:23,280 --> 00:12:26,360 Speaker 1: and we gob and manjaro, lots of different options. And 209 00:12:26,720 --> 00:12:29,920 Speaker 1: are those medications the ones that you were talking about, Like, 210 00:12:30,280 --> 00:12:32,520 Speaker 1: if we classify this as a disease, now we have 211 00:12:32,600 --> 00:12:36,560 Speaker 1: a whole arsenal of pharmacy, kinds of medicines that can 212 00:12:36,640 --> 00:12:38,760 Speaker 1: be used to actually take care of this disease. 213 00:12:39,080 --> 00:12:41,120 Speaker 2: Yeah, but you know what's really interesting. I'm glad you 214 00:12:41,160 --> 00:12:43,280 Speaker 2: brought those up, but I want to talk about historically, 215 00:12:43,480 --> 00:12:47,960 Speaker 2: we've actually been using medications to treat obesity since nineteen 216 00:12:48,120 --> 00:12:51,920 Speaker 2: thirty three. So my maternal grandmother was born in nineteen 217 00:12:52,000 --> 00:12:53,800 Speaker 2: thirty three, and I'm going to say that you and 218 00:12:53,880 --> 00:12:56,559 Speaker 2: I were both not quite around since then. So the 219 00:12:56,720 --> 00:13:00,240 Speaker 2: FDA has been approving medigations to treat obesity since way 220 00:13:00,320 --> 00:13:01,880 Speaker 2: back then. Now, I'm gonna say that a lot of 221 00:13:01,920 --> 00:13:05,679 Speaker 2: those medications were problematic. But let's talk about the gop ones, 222 00:13:06,000 --> 00:13:09,360 Speaker 2: which everyone is talking about these days, and let's go 223 00:13:09,440 --> 00:13:13,959 Speaker 2: back to that pathophysiology we just learned about. So the 224 00:13:14,080 --> 00:13:19,480 Speaker 2: way these medications work is they actually stimulate that anorexigenic pathway, 225 00:13:20,000 --> 00:13:22,120 Speaker 2: that pathway of the brain that tells us to eat 226 00:13:22,200 --> 00:13:25,199 Speaker 2: less and store less. So for patients that go on 227 00:13:25,400 --> 00:13:29,520 Speaker 2: these medications, they'll tell you, you know what, I'm really hungry. 228 00:13:30,720 --> 00:13:33,600 Speaker 2: I A so may not even be thirsty because it's 229 00:13:33,640 --> 00:13:38,199 Speaker 2: stimulating that anorexigenic pathway. Not everyone responds to these medicines. 230 00:13:38,520 --> 00:13:41,120 Speaker 2: These are not a cure for the disease of obesity. 231 00:13:41,520 --> 00:13:45,120 Speaker 2: I will repeat that again. These medications are not a 232 00:13:45,320 --> 00:13:51,280 Speaker 2: cure for obesity. They are a treatment amongst treatments for 233 00:13:51,480 --> 00:13:54,360 Speaker 2: the disease of obesity. Okay, actually, don't repeat it a 234 00:13:54,400 --> 00:13:59,280 Speaker 2: third time. These medications are not a cure for obesity. 235 00:13:59,440 --> 00:14:04,360 Speaker 2: But for those patients that are responders, they stimulate that 236 00:14:04,559 --> 00:14:08,480 Speaker 2: anorexogenic pathway. And so for those that are listening that 237 00:14:08,600 --> 00:14:10,680 Speaker 2: may be one of these that are responders, they'll be like, yeah, 238 00:14:10,840 --> 00:14:14,240 Speaker 2: you know, it does seem to stimulate that pathway. Wow, 239 00:14:14,320 --> 00:14:18,079 Speaker 2: I do feel different. For those that use kind of 240 00:14:18,160 --> 00:14:21,160 Speaker 2: more layman's terms and terms that I wouldn't use per se, 241 00:14:21,280 --> 00:14:23,880 Speaker 2: but they'll say it quiet's this food noise. And I'm 242 00:14:23,880 --> 00:14:29,040 Speaker 2: putting that in quotes on purpose because they may be 243 00:14:29,480 --> 00:14:32,840 Speaker 2: preoccupied with this idea of like what's my next meal? 244 00:14:33,240 --> 00:14:36,280 Speaker 2: Not only was my next meal, what are the mills 245 00:14:36,320 --> 00:14:38,920 Speaker 2: for the rest of the week or the next two weeks. 246 00:14:39,000 --> 00:14:42,080 Speaker 2: Like there's a preoccupat pation of like, gosh, I need 247 00:14:42,160 --> 00:14:43,640 Speaker 2: to be thinking about that. I need to be mil prep, 248 00:14:43,760 --> 00:14:44,680 Speaker 2: I need to be doing this, I need to be 249 00:14:44,760 --> 00:14:48,640 Speaker 2: doing that. But it turns down that noise. Think about 250 00:14:48,680 --> 00:14:52,400 Speaker 2: like turning up the volume or whatever your favorite music is, 251 00:14:53,440 --> 00:14:56,760 Speaker 2: and then all of a sudden it's on mute and 252 00:14:56,880 --> 00:14:59,920 Speaker 2: you're like, well, look at that. My patients may ask 253 00:15:00,040 --> 00:15:01,920 Speaker 2: established Eaver, is this what you feel all of the time? 254 00:15:01,920 --> 00:15:04,760 Speaker 2: And I'm like, I guess, Oh, I don't know, because 255 00:15:04,760 --> 00:15:06,960 Speaker 2: I don't that's not something that I sense, but I 256 00:15:07,200 --> 00:15:11,280 Speaker 2: understand what they're talking about. So it stimulates that pathway 257 00:15:11,320 --> 00:15:13,960 Speaker 2: and then it down regulates that other pathway, that O 258 00:15:14,080 --> 00:15:17,040 Speaker 2: rexygenic pathway that they may have been struggling with for 259 00:15:17,160 --> 00:15:20,840 Speaker 2: quite some time. It downregulates that. So this is how 260 00:15:20,960 --> 00:15:25,080 Speaker 2: those medications work. That Ozimpic and will govy ozempic wigov 261 00:15:25,280 --> 00:15:29,240 Speaker 2: are the semaglatide. They are the exact same drug, Ozimpic 262 00:15:29,280 --> 00:15:32,240 Speaker 2: as the trade name for patients with diabetes with govy 263 00:15:32,360 --> 00:15:37,120 Speaker 2: for patients with obesity. Manjaro is a dual agonis a 264 00:15:37,200 --> 00:15:40,800 Speaker 2: combination of two different drugs, a gop one. Gop one 265 00:15:40,920 --> 00:15:45,240 Speaker 2: stands for lucagon like peptide one, and then it has 266 00:15:45,320 --> 00:15:48,320 Speaker 2: another agent in it, what's called a GIP or glucose 267 00:15:48,480 --> 00:15:54,360 Speaker 2: insulin tropic polypeptide. Two medicines brought together all of these things. However, 268 00:15:54,440 --> 00:15:58,840 Speaker 2: I need this to know. Gop one is in our body. Okay, 269 00:15:58,920 --> 00:16:01,480 Speaker 2: let me repeat that again. Gop one's all of us 270 00:16:01,520 --> 00:16:03,240 Speaker 2: that are human. I don't know if there's any ai 271 00:16:03,400 --> 00:16:05,640 Speaker 2: robox work walking around yet, but all of us that 272 00:16:05,720 --> 00:16:08,880 Speaker 2: are human have gop ones in our body. For those 273 00:16:08,920 --> 00:16:11,440 Speaker 2: of us that have more gop one on board, we 274 00:16:11,640 --> 00:16:16,160 Speaker 2: have a leaner phenotype because it's stimulating that anorexogenic pathway. 275 00:16:16,640 --> 00:16:18,840 Speaker 2: So we don't need to administer a SHOP because we 276 00:16:18,880 --> 00:16:22,840 Speaker 2: already have it on board. GIP, the dual agon is 277 00:16:22,920 --> 00:16:26,120 Speaker 2: this on board. We also have GP in our body. 278 00:16:26,200 --> 00:16:30,400 Speaker 2: GOP stands for glucos insulinentropic polypeptide. So they combined these 279 00:16:30,480 --> 00:16:34,600 Speaker 2: two things. It is more powerful than the gop one alone. Okay, 280 00:16:35,480 --> 00:16:39,520 Speaker 2: It helps work together to stimulate even more total body 281 00:16:39,560 --> 00:16:43,040 Speaker 2: weight loss by helping to regulate these pathways and our 282 00:16:43,080 --> 00:16:46,720 Speaker 2: brain in our gut. So hopefully that helps us understand 283 00:16:46,840 --> 00:16:49,840 Speaker 2: that in order for us to have targets, there has 284 00:16:49,920 --> 00:16:53,280 Speaker 2: to be some disease process to target right for us 285 00:16:53,360 --> 00:16:53,840 Speaker 2: to work on. 286 00:16:55,480 --> 00:16:57,400 Speaker 1: And so I appreciate you sharing because I did not 287 00:16:57,520 --> 00:17:00,840 Speaker 1: know that there were other medications that were designed specifically 288 00:17:00,960 --> 00:17:05,360 Speaker 1: to help with the disease of obesity. But my understanding 289 00:17:05,480 --> 00:17:08,800 Speaker 1: is that the golp ones, of course, were originally designed 290 00:17:08,960 --> 00:17:12,160 Speaker 1: to or they found that they worked with diabetes management, right, 291 00:17:12,600 --> 00:17:16,360 Speaker 1: and so is the weight loss an off label impact 292 00:17:16,400 --> 00:17:19,720 Speaker 1: that they found? How did we realize that golp ones 293 00:17:19,840 --> 00:17:21,600 Speaker 1: also could be used for obesity? 294 00:17:21,880 --> 00:17:25,000 Speaker 2: Absolutely, So let's go back to twenty years ago when 295 00:17:25,040 --> 00:17:28,680 Speaker 2: these medications were first approved for the treatment of type 296 00:17:28,720 --> 00:17:32,480 Speaker 2: two diabetes, and that was a drug called exenotite was 297 00:17:32,800 --> 00:17:36,560 Speaker 2: is still called axenotype bieta, And when they were doing 298 00:17:36,640 --> 00:17:39,520 Speaker 2: those first trials that were published, they started to notice 299 00:17:39,720 --> 00:17:43,520 Speaker 2: a secondary benefit from these medications. They were noticing that 300 00:17:43,560 --> 00:17:47,359 Speaker 2: the patients going on these medicines, patients with type two diabetes, 301 00:17:47,920 --> 00:17:52,640 Speaker 2: were getting a secondary benefit with weight being a positive response. 302 00:17:53,200 --> 00:17:56,119 Speaker 2: Most of the medications used to treat type two diabetes 303 00:17:56,160 --> 00:18:02,240 Speaker 2: at the time were drugs called safana aureeas and like glipizide, glameaparide, 304 00:18:02,480 --> 00:18:06,280 Speaker 2: these types of medications. Unfortunately, those medications typically cause weight gain, 305 00:18:06,760 --> 00:18:10,080 Speaker 2: and so they were noticing, Wait a minute, what's going 306 00:18:10,160 --> 00:18:12,840 Speaker 2: on here. We're noticing some weight loss, so we're getting 307 00:18:12,920 --> 00:18:15,520 Speaker 2: dual benefits. It's also important to note because I always 308 00:18:15,680 --> 00:18:18,800 Speaker 2: hear this argument, oh, we're taking medications from patients with 309 00:18:18,880 --> 00:18:23,399 Speaker 2: type two diabetes. Let's get something straight. People, eighty percent 310 00:18:23,480 --> 00:18:26,080 Speaker 2: of patients with type two diabetes also have obesity. So 311 00:18:26,119 --> 00:18:28,280 Speaker 2: are we really taking it away? Are we just treating 312 00:18:28,320 --> 00:18:30,840 Speaker 2: the same people? First, Let's get that, let's get that 313 00:18:30,840 --> 00:18:33,960 Speaker 2: into wraps. And we must also note that when we're 314 00:18:34,000 --> 00:18:37,280 Speaker 2: looking at these medications. Now, these medications are approved in 315 00:18:37,400 --> 00:18:41,600 Speaker 2: both patient populations. They're proved for patients with type two diabetes, 316 00:18:42,160 --> 00:18:47,359 Speaker 2: and notice and capital A, N and D they're proved 317 00:18:47,400 --> 00:18:51,359 Speaker 2: in patients with obesity. Okay, so two patient populations, but 318 00:18:51,560 --> 00:18:55,520 Speaker 2: notice there is a strong overlap between those two patient populations. 319 00:18:55,600 --> 00:19:00,960 Speaker 2: Patients with type two diabetes unfortunately often half obesity conc currently. Okay, 320 00:19:01,480 --> 00:19:03,920 Speaker 2: So they noticed when they looked at those trials and 321 00:19:04,040 --> 00:19:08,520 Speaker 2: trial after trial after trial, they were noticing some weight benefit. Now, 322 00:19:08,600 --> 00:19:11,000 Speaker 2: when you look back at that initial gop one that 323 00:19:11,119 --> 00:19:13,640 Speaker 2: was approved that we just talked about exanotide or bieta, 324 00:19:14,600 --> 00:19:17,199 Speaker 2: it was a much weaker gop one, So that's why 325 00:19:17,280 --> 00:19:19,480 Speaker 2: you weren't hearing about it so much. And there was 326 00:19:19,520 --> 00:19:21,760 Speaker 2: no social media anyway back then, so you aren't going 327 00:19:21,800 --> 00:19:23,960 Speaker 2: to probably hear about it in the same way. But 328 00:19:24,080 --> 00:19:26,359 Speaker 2: as they started to refine and they moved over to 329 00:19:26,520 --> 00:19:30,960 Speaker 2: drugs like dula glutide or loraglatide and et cetera, et cetera, 330 00:19:31,400 --> 00:19:34,320 Speaker 2: they started to continue to see this so much so 331 00:19:34,440 --> 00:19:37,720 Speaker 2: they were like, hm, particularly Novo Nordisk, who was the 332 00:19:37,920 --> 00:19:42,160 Speaker 2: first to get an agent out and approved for obesity. 333 00:19:43,280 --> 00:19:48,120 Speaker 2: They said, okay, well, let's just get something approved specifically 334 00:19:48,280 --> 00:19:52,200 Speaker 2: for obesity, and that was loraglatide that was a once 335 00:19:52,480 --> 00:19:56,560 Speaker 2: daily injection under the trade name of sex Cinda after 336 00:19:56,760 --> 00:20:00,399 Speaker 2: Victoza was approved, so once daily injection, and they were like, 337 00:20:00,840 --> 00:20:03,640 Speaker 2: let's see, let's look at this both in adult patients 338 00:20:04,080 --> 00:20:08,800 Speaker 2: and in pediatric patients. And hence the first medication gets 339 00:20:08,840 --> 00:20:13,560 Speaker 2: across the finish line specifically to treat patients with obesity. Now, 340 00:20:13,640 --> 00:20:15,879 Speaker 2: I can tell you that a once daily injection was 341 00:20:15,960 --> 00:20:19,960 Speaker 2: not quite as popular as a once weekly injection, and 342 00:20:20,680 --> 00:20:23,680 Speaker 2: as we also saw the percentage of weight loss not 343 00:20:23,840 --> 00:20:26,480 Speaker 2: quite be the same as what we saw with semaglatides. 344 00:20:26,520 --> 00:20:30,840 Speaker 2: So semaglatide is that ozempic and mongovi we started to 345 00:20:30,840 --> 00:20:34,600 Speaker 2: see fifteen percent total body weight loss. Now that created 346 00:20:34,680 --> 00:20:38,159 Speaker 2: some interest from the greater population and from doctors. But 347 00:20:38,280 --> 00:20:40,840 Speaker 2: not only the total body weight loss. It was the 348 00:20:40,960 --> 00:20:44,040 Speaker 2: resolution of comorbid conditions. And what do I mean by that. 349 00:20:44,600 --> 00:20:47,800 Speaker 2: We started to see a reduction in things like major 350 00:20:48,320 --> 00:20:52,760 Speaker 2: adverse coronary events like heart attacks and strokes, improvement in 351 00:20:52,840 --> 00:20:57,320 Speaker 2: things like obstructive sleep, apnea improvement, and kidney outcomes improvement 352 00:20:57,359 --> 00:20:59,600 Speaker 2: and heart failure. All of these things we started to 353 00:20:59,680 --> 00:21:04,400 Speaker 2: see that really increased the interests of doctors. I will 354 00:21:04,440 --> 00:21:06,920 Speaker 2: say that from the general population, I think it was 355 00:21:07,000 --> 00:21:10,160 Speaker 2: the total body weight loss that really increased the interests. 356 00:21:12,200 --> 00:21:12,520 Speaker 2: Got it. 357 00:21:12,800 --> 00:21:15,200 Speaker 1: And so now we are at the stage where there's 358 00:21:15,280 --> 00:21:18,119 Speaker 1: been more development in the GLP ones and now has 359 00:21:18,280 --> 00:21:20,680 Speaker 1: led to the interest and kind of the excitement that 360 00:21:20,800 --> 00:21:22,960 Speaker 1: lots of people are expressing in terms of being able 361 00:21:23,040 --> 00:21:24,600 Speaker 1: to use these exactly. 362 00:21:24,720 --> 00:21:26,720 Speaker 2: I think that just more so, let's look at that 363 00:21:26,760 --> 00:21:29,400 Speaker 2: true zeppetite, that dual agonist. Right, we saw the fifteen 364 00:21:29,440 --> 00:21:32,359 Speaker 2: percent and some maglati. Now we're seeing numbers of like 365 00:21:32,480 --> 00:21:35,879 Speaker 2: twenty two percent in that particular medication. So people are like, 366 00:21:36,080 --> 00:21:39,080 Speaker 2: what twenty two percent? This is average? Okay. So for 367 00:21:39,160 --> 00:21:42,720 Speaker 2: those that are listening averages averages, think about when you're 368 00:21:42,760 --> 00:21:44,720 Speaker 2: in school and you got the average score and some 369 00:21:44,800 --> 00:21:47,200 Speaker 2: people got a higher score and some people got a 370 00:21:47,240 --> 00:21:49,440 Speaker 2: lower score. Average is average. So we just have to 371 00:21:49,520 --> 00:21:52,600 Speaker 2: be aware that not everyone is an average responder or 372 00:21:52,640 --> 00:21:55,720 Speaker 2: above average responder. And that's really important, which is why 373 00:21:55,960 --> 00:21:59,440 Speaker 2: I made that comment earlier. It is not a cure 374 00:21:59,680 --> 00:22:02,399 Speaker 2: right on, everyone is going to respond. There are going 375 00:22:02,440 --> 00:22:05,040 Speaker 2: to be some high responders and some low responders. And 376 00:22:05,200 --> 00:22:06,720 Speaker 2: by that it's not just in terms of like I 377 00:22:06,800 --> 00:22:09,520 Speaker 2: told you that weight loss, looking at the resolution of 378 00:22:09,600 --> 00:22:14,600 Speaker 2: obesity relay, disease improvement, and metabolic profile like things like 379 00:22:14,800 --> 00:22:19,240 Speaker 2: your liver numbers or your cholesterol numbers or blood pressure, 380 00:22:19,440 --> 00:22:21,200 Speaker 2: these things that we really care about in terms of 381 00:22:21,240 --> 00:22:24,560 Speaker 2: improving your overall health. Waste circumference, right, how much way 382 00:22:24,600 --> 00:22:27,000 Speaker 2: you're hearing around the mid section, which we know predispose 383 00:22:27,080 --> 00:22:29,359 Speaker 2: this to things like stroke and heart attacks. These are 384 00:22:29,400 --> 00:22:31,800 Speaker 2: really important things when I'm working with my patients that 385 00:22:31,880 --> 00:22:34,600 Speaker 2: we go over how well does that blood sugar improve? 386 00:22:34,960 --> 00:22:36,960 Speaker 2: Are we seeing that come down? Those are things to 387 00:22:37,119 --> 00:22:38,359 Speaker 2: really really pay attention to. 388 00:22:39,280 --> 00:22:41,760 Speaker 1: Got it, And you're giving us the perfect segue into 389 00:22:42,040 --> 00:22:45,480 Speaker 1: some of my next questions around if somebody is thinking like, hey, 390 00:22:45,760 --> 00:22:48,040 Speaker 1: maybe this will work for me, what kinds of things 391 00:22:48,080 --> 00:22:50,040 Speaker 1: should they be thinking about, and maybe what kinds of 392 00:22:50,119 --> 00:22:52,840 Speaker 1: conversations should they have with their physicians if they're considering 393 00:22:52,920 --> 00:22:53,520 Speaker 1: GLP one. 394 00:22:54,040 --> 00:22:58,399 Speaker 2: So I think it's really important to think about is 395 00:22:58,520 --> 00:23:01,119 Speaker 2: this a disease they actually have. I don't want you 396 00:23:01,760 --> 00:23:03,280 Speaker 2: going on this medication. 397 00:23:04,040 --> 00:23:06,040 Speaker 3: Oh I just need five pounds. I need to look 398 00:23:06,160 --> 00:23:08,639 Speaker 3: five pounds because I want to look cute for that 399 00:23:08,760 --> 00:23:11,359 Speaker 3: winning I'm going to be in, you know, and you 400 00:23:11,440 --> 00:23:13,119 Speaker 3: know I want to look cute because I'm going on 401 00:23:13,200 --> 00:23:15,479 Speaker 3: a cruise and you know, I really want to look 402 00:23:15,520 --> 00:23:16,240 Speaker 3: cute in my biking. 403 00:23:16,480 --> 00:23:19,000 Speaker 2: This is not no, I'm not This is not what 404 00:23:19,119 --> 00:23:22,920 Speaker 2: this is about. This is for treating disease. Okay, So 405 00:23:23,400 --> 00:23:25,280 Speaker 2: a lot of people have gotten into this idea of 406 00:23:25,400 --> 00:23:29,600 Speaker 2: doing this for vanity. This is not that conversation. I 407 00:23:29,720 --> 00:23:32,480 Speaker 2: know a lot of people, not patients I treat. But 408 00:23:32,720 --> 00:23:37,639 Speaker 2: I've heard in the ethers in the social media community, 409 00:23:37,920 --> 00:23:40,360 Speaker 2: whether it be ig or TikTok, that people are doing 410 00:23:40,440 --> 00:23:45,800 Speaker 2: this for vanity reasons. This is not that conversation, and 411 00:23:45,920 --> 00:23:48,520 Speaker 2: I really hope people are taking this seriously because when 412 00:23:48,520 --> 00:23:51,159 Speaker 2: you go want a medication of this kind, this is 413 00:23:51,240 --> 00:23:56,840 Speaker 2: a long term commitment. We're treating a chronic disease. If 414 00:23:57,000 --> 00:24:01,399 Speaker 2: this medication or medication class works for you, you are 415 00:24:01,520 --> 00:24:06,320 Speaker 2: to use it indefinitely and definitely means for the rest 416 00:24:06,960 --> 00:24:10,240 Speaker 2: of your life, because if it works, you need to 417 00:24:10,320 --> 00:24:12,159 Speaker 2: use it for the rest of your life. If you 418 00:24:12,359 --> 00:24:15,680 Speaker 2: take the medication away and it worked for you, you 419 00:24:16,280 --> 00:24:20,880 Speaker 2: will regain whatever you lost. So if that was fill 420 00:24:20,920 --> 00:24:24,119 Speaker 2: in the blank number of pounds, forty fifty whatever, I 421 00:24:24,200 --> 00:24:27,159 Speaker 2: don't know, you will regain that. And then you might know, well, 422 00:24:27,200 --> 00:24:30,080 Speaker 2: how do you know that, because we've done studies. We've 423 00:24:30,119 --> 00:24:33,000 Speaker 2: done studies that demonstrate this true fact. And it's not 424 00:24:33,200 --> 00:24:36,800 Speaker 2: just about regaining the weights. Also, whatever health benefits you've 425 00:24:37,000 --> 00:24:40,920 Speaker 2: gleaned from being on the medication, unfortunately, those things will 426 00:24:40,960 --> 00:24:43,119 Speaker 2: go away also. So this isn't like I said, a 427 00:24:43,240 --> 00:24:48,280 Speaker 2: vanity conversation. This is about looking at the overall health benefits. Now, 428 00:24:48,760 --> 00:24:52,280 Speaker 2: I think that's a very important conversation to have. One 429 00:24:52,320 --> 00:24:55,760 Speaker 2: of the key issues, however, with these medications is the 430 00:24:56,080 --> 00:25:00,560 Speaker 2: access piece. These medications can be very pricey if not 431 00:25:00,680 --> 00:25:03,000 Speaker 2: covered by your insurance. Now, if you have the best 432 00:25:03,200 --> 00:25:09,200 Speaker 2: insurance plan, maybe you have the Rose Royce Bugatti insurance plan. Okay, 433 00:25:09,400 --> 00:25:12,040 Speaker 2: if you got that, what Rick Ross I've rolled up? 434 00:25:12,040 --> 00:25:13,960 Speaker 2: You know, might Begotti, right, that's what he says. Okay, 435 00:25:14,240 --> 00:25:15,920 Speaker 2: So if you rolled up in that, then you have 436 00:25:16,040 --> 00:25:19,480 Speaker 2: the insurance plan, then that's great. That means you're playing 437 00:25:19,560 --> 00:25:21,280 Speaker 2: like a thirty dollars copay a month and you're like, 438 00:25:21,359 --> 00:25:24,359 Speaker 2: I got this great, fabulous for you. Then this is 439 00:25:24,760 --> 00:25:28,399 Speaker 2: a moved conversation. I'm happy for you. This is a 440 00:25:28,480 --> 00:25:31,800 Speaker 2: non conversation. But let's say you don't have that, then 441 00:25:31,880 --> 00:25:34,919 Speaker 2: these medications can be very, very pricey out of pocket. 442 00:25:35,119 --> 00:25:37,439 Speaker 2: What are we talking about here in the US compared 443 00:25:37,480 --> 00:25:41,560 Speaker 2: to our friends in Canada or in the UK. We're 444 00:25:41,640 --> 00:25:44,680 Speaker 2: talking one thousand plus a month. That is a lot 445 00:25:44,920 --> 00:25:48,840 Speaker 2: right now. I can tell you that Eli Lilly, for example, 446 00:25:48,960 --> 00:25:52,960 Speaker 2: has discounted their prices to three hundred and fifty to 447 00:25:53,040 --> 00:25:55,480 Speaker 2: five hundred a month. That's still a lot a month 448 00:25:55,640 --> 00:26:00,520 Speaker 2: for these medications. So just be aware that if we're 449 00:26:00,560 --> 00:26:03,160 Speaker 2: talking a price point and you don't have coverage, these 450 00:26:03,280 --> 00:26:05,840 Speaker 2: medications can be out of reach. And we're hoping that 451 00:26:06,160 --> 00:26:09,080 Speaker 2: for example, Ela Lilly has an oral that may be 452 00:26:09,160 --> 00:26:11,240 Speaker 2: coming on the market at some point and then you're 453 00:26:11,280 --> 00:26:13,480 Speaker 2: Beary in your future, and we're hoping that will drop 454 00:26:13,600 --> 00:26:16,840 Speaker 2: the price point for an oral medication, not just an 455 00:26:16,880 --> 00:26:20,600 Speaker 2: injectible or a daily oral, that will make it accessible 456 00:26:20,680 --> 00:26:23,640 Speaker 2: to more individuals because the price point is so high. 457 00:26:24,160 --> 00:26:27,440 Speaker 2: We know that patients that have medicare this medication is 458 00:26:27,640 --> 00:26:31,120 Speaker 2: not covered at all if you have obesity. It's only 459 00:26:31,200 --> 00:26:34,159 Speaker 2: covered for patients with type two diabetes. We know in 460 00:26:34,320 --> 00:26:37,840 Speaker 2: certain states with Medicaid not covered. If you happen to 461 00:26:37,880 --> 00:26:40,439 Speaker 2: live in Massachusetts, it is covered. So it just depends 462 00:26:40,480 --> 00:26:42,840 Speaker 2: on which state you are in. How well have your 463 00:26:43,000 --> 00:26:47,400 Speaker 2: legislators the lawmakers govern everything that happens, and if we're 464 00:26:47,440 --> 00:26:50,600 Speaker 2: not seeing that in today's world, I think that we 465 00:26:50,800 --> 00:26:54,280 Speaker 2: are living under a rock. But the legislators are governing coverage, 466 00:26:54,320 --> 00:26:56,639 Speaker 2: and so I think that these are important considerations to 467 00:26:57,000 --> 00:26:59,879 Speaker 2: be having. I think go over sign effects with these 468 00:27:00,080 --> 00:27:03,080 Speaker 2: medications right, this key side effects. I always tell my 469 00:27:03,119 --> 00:27:05,200 Speaker 2: patients the number one, the number two. The number three 470 00:27:05,280 --> 00:27:08,360 Speaker 2: side effect is nausea. Okay, got that number one, number two, 471 00:27:08,400 --> 00:27:11,479 Speaker 2: number three. After that, we have issues with constipation. These 472 00:27:11,560 --> 00:27:14,720 Speaker 2: medications do slow movement through the GI track. I know 473 00:27:14,800 --> 00:27:16,639 Speaker 2: this kind of sounds like a smelly conversation to have 474 00:27:16,760 --> 00:27:20,000 Speaker 2: with your doctor, but this is a really important conversation. 475 00:27:20,160 --> 00:27:22,840 Speaker 2: You would have a good bowel regimen. If you're like 476 00:27:22,960 --> 00:27:25,240 Speaker 2: a have a I you know, had a bowel movement 477 00:27:25,680 --> 00:27:28,440 Speaker 2: once every five or six days. That is not normal. Okay, 478 00:27:28,520 --> 00:27:30,760 Speaker 2: that is just not normal. This is something that you 479 00:27:30,880 --> 00:27:33,119 Speaker 2: really need to be working with your doctor. You need 480 00:27:33,160 --> 00:27:35,040 Speaker 2: to be hydrating. We need to be doing things to 481 00:27:35,080 --> 00:27:37,840 Speaker 2: improve that bowel regiment because we don't want things to 482 00:27:37,880 --> 00:27:41,040 Speaker 2: get stuck. I would say other things that we want 483 00:27:41,080 --> 00:27:42,960 Speaker 2: to think about, things like fatigue. You know, are you 484 00:27:43,040 --> 00:27:46,119 Speaker 2: have running into issues with fatigue with these medications? Are 485 00:27:46,160 --> 00:27:49,280 Speaker 2: you running into more serious side effects which could be 486 00:27:49,320 --> 00:27:52,160 Speaker 2: things like pancreatitis where we would need to stop the medications, 487 00:27:52,320 --> 00:27:55,719 Speaker 2: or are you losing weight so rapidly developed gallbladder issues 488 00:27:56,600 --> 00:27:58,840 Speaker 2: if we if you've already had your gallbladder out, not 489 00:27:58,960 --> 00:28:01,359 Speaker 2: such an issue if you're on the medications. If we 490 00:28:01,640 --> 00:28:04,840 Speaker 2: need to take your gallbladder out, that's not necessarily a problem. 491 00:28:05,240 --> 00:28:08,720 Speaker 2: You can develop issues with your gallbladder surrounding wrap up 492 00:28:08,720 --> 00:28:12,800 Speaker 2: weight loss from just lifestyle modification, or with surgery or 493 00:28:12,840 --> 00:28:14,920 Speaker 2: with other conditions. It's just something that we need to 494 00:28:14,960 --> 00:28:18,320 Speaker 2: be mindful of. Partricularly started developing certain types of pain. 495 00:28:18,400 --> 00:28:20,720 Speaker 2: So these are conversations I think you should be having 496 00:28:20,800 --> 00:28:23,440 Speaker 2: with your doctor if you're on these medications. 497 00:28:24,280 --> 00:28:36,200 Speaker 1: More from our conversation after the break, I want to 498 00:28:36,240 --> 00:28:38,719 Speaker 1: go back to the conversation around the cost of the medication, 499 00:28:38,800 --> 00:28:42,040 Speaker 1: doctor Fatima. So is the cost reflective of it kind 500 00:28:42,080 --> 00:28:44,680 Speaker 1: of being a newer drug and like there's no real 501 00:28:44,760 --> 00:28:47,480 Speaker 1: generic and so of course it's more expensive. Or is 502 00:28:47,560 --> 00:28:50,480 Speaker 1: it a case of you know, the field not really 503 00:28:50,560 --> 00:28:53,480 Speaker 1: recognizing OBCD as a disease that can be treated and 504 00:28:53,640 --> 00:28:57,400 Speaker 1: then it's feeling like a luxury like kind of medication 505 00:28:57,480 --> 00:28:59,360 Speaker 1: as opposed to like, know, this person needs this to 506 00:28:59,560 --> 00:29:01,560 Speaker 1: kind of be I'm going to say it's. 507 00:29:01,680 --> 00:29:06,440 Speaker 2: Both, and let's talk about that. So Number one, these companies, 508 00:29:06,520 --> 00:29:09,239 Speaker 2: these medications haven't turned into generic yet. And so when 509 00:29:09,280 --> 00:29:13,080 Speaker 2: they haven't turned into generic, that means that there can't 510 00:29:13,080 --> 00:29:18,000 Speaker 2: be any competition yet for these medications. Now I'm going 511 00:29:18,080 --> 00:29:22,200 Speaker 2: to give a caveat because unfortunately there are compounded versions 512 00:29:22,640 --> 00:29:28,120 Speaker 2: that existed for these medications. These medications have now been 513 00:29:28,280 --> 00:29:31,680 Speaker 2: ruled to be illegal in the country. But this has 514 00:29:31,720 --> 00:29:35,680 Speaker 2: only happened within the last few months. With some people 515 00:29:35,760 --> 00:29:38,800 Speaker 2: that may be listening to what I'm talking about them maybe, well, 516 00:29:38,840 --> 00:29:42,600 Speaker 2: I get my compounded drug. So there have been strategies 517 00:29:42,640 --> 00:29:46,040 Speaker 2: I think that some compounders have used to develop a 518 00:29:46,120 --> 00:29:50,880 Speaker 2: drug that's cost effective. And I'm doing air quotes because 519 00:29:51,040 --> 00:29:54,280 Speaker 2: these are not the actual drug. And the reason why 520 00:29:54,400 --> 00:29:58,280 Speaker 2: I never prescribe compounded medications in this field is that 521 00:29:58,400 --> 00:30:02,440 Speaker 2: they've never undergone in any research trials. So how we're 522 00:30:02,480 --> 00:30:08,400 Speaker 2: prescribing them to whomever, Jane or whomever, I don't know 523 00:30:08,640 --> 00:30:12,400 Speaker 2: any of the safety data for that specific agent compared 524 00:30:12,480 --> 00:30:16,120 Speaker 2: to the trials that were performed on the seventeen thousand 525 00:30:16,240 --> 00:30:20,360 Speaker 2: that were in some magnetide or whatever. And so I 526 00:30:20,560 --> 00:30:26,720 Speaker 2: believe in giving my patients the best possible treatment and 527 00:30:27,200 --> 00:30:30,960 Speaker 2: something that I will want for myself or my siblings 528 00:30:31,080 --> 00:30:34,040 Speaker 2: or my parents. And if I don't feel comfortable in 529 00:30:34,360 --> 00:30:38,120 Speaker 2: giving my patients exactly that then I won't prescribe it. 530 00:30:38,160 --> 00:30:40,680 Speaker 2: So I will not use the compounded because I can't 531 00:30:40,680 --> 00:30:42,440 Speaker 2: give you the paper that shows you this is what 532 00:30:42,560 --> 00:30:44,640 Speaker 2: we can see. Oh, we're going to see forty five 533 00:30:44,720 --> 00:30:46,640 Speaker 2: percent nausea, and then we're going to see you know, 534 00:30:46,720 --> 00:30:49,560 Speaker 2: this is what I'm expecting. So that's an issue. Now 535 00:30:49,640 --> 00:30:51,560 Speaker 2: the compound it will say, oh, well, we're going to 536 00:30:51,600 --> 00:30:53,239 Speaker 2: give it to you at this cheap price. But it's 537 00:30:53,360 --> 00:30:57,960 Speaker 2: like you're going to get something from the makeshift store 538 00:30:58,120 --> 00:30:59,720 Speaker 2: and you're like, I don't know if that's going to 539 00:30:59,760 --> 00:31:02,280 Speaker 2: really tastes like I wanted to taste it, may or 540 00:31:02,320 --> 00:31:04,600 Speaker 2: may not go bad. It's kind of something like that, 541 00:31:04,760 --> 00:31:09,120 Speaker 2: and we unfortunately saw several deaths last year and over 542 00:31:09,240 --> 00:31:13,040 Speaker 2: nine hundred hospitalizations from some of these compounded drugs. So 543 00:31:13,200 --> 00:31:15,400 Speaker 2: from a safety perspective, I think we just need to 544 00:31:15,440 --> 00:31:16,960 Speaker 2: be well, now I'm not saying that you won't have 545 00:31:17,120 --> 00:31:20,000 Speaker 2: something from the actual agent, but at least we know 546 00:31:20,320 --> 00:31:22,920 Speaker 2: what to expect, and if you were to go to 547 00:31:23,040 --> 00:31:25,480 Speaker 2: the hospital or whatever, we know what agent we need 548 00:31:25,520 --> 00:31:27,200 Speaker 2: to respond to you. What are we looking for? Kind 549 00:31:27,240 --> 00:31:29,000 Speaker 2: of like it was able to roll off. What are 550 00:31:29,080 --> 00:31:32,760 Speaker 2: these adverse events that we can anticipate. I know what 551 00:31:32,880 --> 00:31:35,920 Speaker 2: to look for, but if you're giving me some type 552 00:31:35,920 --> 00:31:37,440 Speaker 2: of combat, I don't what am I I don't know 553 00:31:37,480 --> 00:31:39,400 Speaker 2: what it is really like, what is it? I don't know? 554 00:31:40,160 --> 00:31:41,840 Speaker 1: M thank you so much for it. 555 00:31:41,960 --> 00:31:43,320 Speaker 2: Yeah, for breaking that down like that. 556 00:31:43,800 --> 00:31:45,960 Speaker 1: So one of the things that has also been a 557 00:31:46,120 --> 00:31:48,520 Speaker 1: large part of the conversation is this idea of something 558 00:31:48,560 --> 00:31:52,280 Speaker 1: called the ozimbic face right that people's faces start to 559 00:31:52,360 --> 00:31:55,760 Speaker 1: look different after using the medication. Is this accurate and 560 00:31:55,880 --> 00:31:58,280 Speaker 1: if so, is there a way to prevent or avoid this? 561 00:31:59,040 --> 00:32:03,080 Speaker 2: So this idea ozimpic base, ozempic butt, all the things, 562 00:32:03,560 --> 00:32:07,840 Speaker 2: is it really specific to ozimpic or any of the compounds. 563 00:32:08,320 --> 00:32:11,440 Speaker 2: Whenever someone loses weight or a large amount of weight, 564 00:32:11,720 --> 00:32:13,680 Speaker 2: we have fat stores. So we have bat stores in 565 00:32:13,720 --> 00:32:15,600 Speaker 2: our face, we have fat stores in our butt. I 566 00:32:15,760 --> 00:32:18,120 Speaker 2: e ad a post right that we've talked about, and 567 00:32:18,280 --> 00:32:20,520 Speaker 2: so you can imagine that if you lose a lot 568 00:32:20,600 --> 00:32:24,400 Speaker 2: of weight, you don't selectively choose where you lose weight, right, 569 00:32:24,520 --> 00:32:26,520 Speaker 2: like you can't be like you know what, I feel 570 00:32:26,560 --> 00:32:28,720 Speaker 2: like this is like a going back to like my 571 00:32:28,800 --> 00:32:31,360 Speaker 2: childhood and it's like zap here, you know, like you 572 00:32:31,440 --> 00:32:35,600 Speaker 2: and that from this particular area is you just lose 573 00:32:35,680 --> 00:32:37,680 Speaker 2: all over it, and so people may feel like they're 574 00:32:37,760 --> 00:32:41,280 Speaker 2: kind of more gaunt if they lose and they lose 575 00:32:41,360 --> 00:32:45,160 Speaker 2: so much from their whole body. So what I've heard 576 00:32:45,200 --> 00:32:49,040 Speaker 2: from some of my dermatology colleagues or my facial plastic 577 00:32:49,120 --> 00:32:52,320 Speaker 2: surgeon colleagues is people may do I don't even know 578 00:32:52,360 --> 00:32:56,800 Speaker 2: all the terminologis and not this like fillers and different things, 579 00:32:56,920 --> 00:33:00,280 Speaker 2: because they feel like they may have lost more if 580 00:33:00,280 --> 00:33:03,120 Speaker 2: they lose. They are high responders to these medications, but 581 00:33:03,240 --> 00:33:06,440 Speaker 2: it's not specific, like I said, to just these medications. 582 00:33:06,560 --> 00:33:10,120 Speaker 2: If they lost a lot with diet and exercise, if 583 00:33:10,160 --> 00:33:13,080 Speaker 2: they lost a lot from surgical interventions, whatever it might be. 584 00:33:13,200 --> 00:33:15,440 Speaker 2: It's so it's not specific to the medications. 585 00:33:16,240 --> 00:33:19,600 Speaker 1: Got it. What are some of the other big misconceptions 586 00:33:19,640 --> 00:33:21,080 Speaker 1: you think about gop ones? 587 00:33:21,960 --> 00:33:23,920 Speaker 2: Like I said, I think people think these are miracle drugs, 588 00:33:23,960 --> 00:33:27,280 Speaker 2: like they're just magically going to work, and that's not true. 589 00:33:27,760 --> 00:33:30,560 Speaker 2: Like I said, there are some high responders. I think 590 00:33:30,680 --> 00:33:33,720 Speaker 2: that patients presume that if they come off that they'll 591 00:33:33,840 --> 00:33:37,080 Speaker 2: just completely stay the same and that they won't regain 592 00:33:37,160 --> 00:33:41,240 Speaker 2: the weight. A large majority of patients will, and I 593 00:33:41,320 --> 00:33:44,160 Speaker 2: think that it's important to recognize that because these are 594 00:33:44,320 --> 00:33:48,120 Speaker 2: working so prominently on how the brain sees weight, I 595 00:33:48,240 --> 00:33:51,600 Speaker 2: think that people think that they're the easy way out. 596 00:33:51,800 --> 00:33:54,239 Speaker 2: I don't see these as per se, the easy way 597 00:33:54,320 --> 00:33:56,920 Speaker 2: out for a lot of people that have struggled their 598 00:33:56,960 --> 00:34:01,040 Speaker 2: whole life, or maybe they've struggled after they had children, 599 00:34:01,160 --> 00:34:04,680 Speaker 2: or maybe they struggle post menopause or whatever the reason 600 00:34:04,960 --> 00:34:07,400 Speaker 2: of why they ended up developing obec It doesn't matter 601 00:34:07,520 --> 00:34:10,360 Speaker 2: what it is. This may be a tool in the 602 00:34:10,440 --> 00:34:12,840 Speaker 2: toolkit that helps them to achieve a healthy weight. And 603 00:34:12,920 --> 00:34:15,920 Speaker 2: so this idea that it's someone that's just you know, 604 00:34:16,120 --> 00:34:18,400 Speaker 2: going the easy way out, I don't see it as that. 605 00:34:18,520 --> 00:34:21,000 Speaker 2: So I think these are all misconceptions surrounding the use 606 00:34:21,040 --> 00:34:21,839 Speaker 2: of gop ones. 607 00:34:22,920 --> 00:34:24,360 Speaker 1: The doctor of Vitiama, I know a lot of your 608 00:34:24,440 --> 00:34:27,000 Speaker 1: work has also been around like the black community and 609 00:34:27,080 --> 00:34:29,360 Speaker 1: like talking about obesity and like how that may be 610 00:34:29,800 --> 00:34:32,879 Speaker 1: connected to like culture and like food and those kinds 611 00:34:32,920 --> 00:34:35,600 Speaker 1: of things. What are you seeing or do you feel 612 00:34:35,680 --> 00:34:38,239 Speaker 1: like this is promising, like the advances that we are 613 00:34:38,239 --> 00:34:40,880 Speaker 1: seeing with gop ones and other medications in terms of 614 00:34:40,960 --> 00:34:43,160 Speaker 1: what it looks like to have obesity management in the 615 00:34:43,200 --> 00:34:44,240 Speaker 1: Black women community. 616 00:34:44,719 --> 00:34:48,240 Speaker 2: Yes, you know, I see very large percentage of black 617 00:34:48,440 --> 00:34:52,200 Speaker 2: women and men, but mostly women. For my guys, I 618 00:34:52,200 --> 00:34:54,520 Speaker 2: don't know if you're listening out there. And I think 619 00:34:54,600 --> 00:34:57,680 Speaker 2: the reason why that is is because when you see 620 00:34:57,680 --> 00:35:00,600 Speaker 2: a black woman in the space doing this, I think 621 00:35:00,680 --> 00:35:03,239 Speaker 2: you feel comfortable going to see a black woman. The 622 00:35:03,320 --> 00:35:05,640 Speaker 2: first person I saw this morning was a black woman, 623 00:35:05,719 --> 00:35:09,719 Speaker 2: and I think we sense comfort in seeing each other. 624 00:35:10,360 --> 00:35:13,600 Speaker 2: I think that we identify with each other's stories. We're 625 00:35:13,640 --> 00:35:16,640 Speaker 2: not all of the same, We're not like this monolithic person, right. 626 00:35:16,719 --> 00:35:19,719 Speaker 2: We are all different. We all have different experiences, but 627 00:35:19,920 --> 00:35:25,200 Speaker 2: we unfortunately have shared trauma, and a lot of how 628 00:35:25,360 --> 00:35:31,040 Speaker 2: we end up with developing this disease disproportionate to our counterparts, 629 00:35:31,400 --> 00:35:36,920 Speaker 2: has to do with our trauma, something we call allostatic load. 630 00:35:38,000 --> 00:35:42,960 Speaker 2: We take on more in society than I think any 631 00:35:43,000 --> 00:35:48,240 Speaker 2: other group. We're always having to prove ourselves in every space, 632 00:35:48,719 --> 00:35:53,239 Speaker 2: and that stress, that chronic stress, whether it's in our families, 633 00:35:53,400 --> 00:35:57,200 Speaker 2: whether it's in work, I think contributes to us having 634 00:35:57,719 --> 00:36:01,040 Speaker 2: the highest OBESI rate of any different group, particularly here 635 00:36:01,080 --> 00:36:04,480 Speaker 2: in the US. When you're able to come in and 636 00:36:04,640 --> 00:36:09,719 Speaker 2: see someone like me and not have to validate who 637 00:36:09,800 --> 00:36:12,799 Speaker 2: you are and explain that piece. Well, let me let 638 00:36:12,840 --> 00:36:14,800 Speaker 2: me explain. Well, you know, as a black woman, you 639 00:36:14,840 --> 00:36:16,480 Speaker 2: don't have to do that with you. I understand that 640 00:36:16,560 --> 00:36:18,719 Speaker 2: because I had I live that each and every day, 641 00:36:18,760 --> 00:36:21,000 Speaker 2: and I fill that each and every day. And so 642 00:36:21,880 --> 00:36:25,279 Speaker 2: when we have tools, whether it's surgery or medication or 643 00:36:25,280 --> 00:36:27,040 Speaker 2: all the life stules or putting any of this, I 644 00:36:27,160 --> 00:36:29,680 Speaker 2: can at least say, okay, yeah, I got that, I 645 00:36:29,760 --> 00:36:31,719 Speaker 2: live that piece. Let's talk about what we're going to 646 00:36:31,800 --> 00:36:34,440 Speaker 2: do about it now. Okay, whether it's in this family 647 00:36:34,840 --> 00:36:36,680 Speaker 2: as because I take care of a lot of families 648 00:36:36,840 --> 00:36:40,800 Speaker 2: of black women, but let me help take that burden 649 00:36:41,719 --> 00:36:44,640 Speaker 2: off of your table, and let's try to find what 650 00:36:44,800 --> 00:36:48,040 Speaker 2: works for you. Recognizing that works for you, maybe there's 651 00:36:48,040 --> 00:36:50,680 Speaker 2: a different than what works for your sister or your 652 00:36:50,800 --> 00:36:53,399 Speaker 2: daughter or whatever it is. And I think that these 653 00:36:53,840 --> 00:36:57,680 Speaker 2: tools are helping to alleviate some of that burden, but 654 00:36:57,800 --> 00:37:02,560 Speaker 2: recognizing that that there's other stressors. I'll give one example 655 00:37:02,680 --> 00:37:06,400 Speaker 2: that helps maybe people understand of just the different types 656 00:37:06,440 --> 00:37:08,879 Speaker 2: of people. I might see one of my patients who's 657 00:37:08,920 --> 00:37:10,880 Speaker 2: been with me for twice the time she does happen 658 00:37:10,960 --> 00:37:14,960 Speaker 2: to be on a GOP one. We did her telemedicine 659 00:37:15,040 --> 00:37:17,560 Speaker 2: visit last week, and she was voting clothes in the 660 00:37:17,640 --> 00:37:21,440 Speaker 2: laundromat while we were on the telemedicine visit. Now, I 661 00:37:21,520 --> 00:37:24,680 Speaker 2: don't know how her if she had a white doctor, 662 00:37:24,719 --> 00:37:26,359 Speaker 2: how that would have gone. But I was like, wait, manut, 663 00:37:26,360 --> 00:37:28,480 Speaker 2: you're not voting that sheet right, and she was like, 664 00:37:28,920 --> 00:37:32,480 Speaker 2: I got this doctor standford. But you know what she 665 00:37:32,680 --> 00:37:34,880 Speaker 2: was dealing with. She had just lost something with section 666 00:37:35,040 --> 00:37:37,960 Speaker 2: eight at the same time she was in the laundromat. Actually, 667 00:37:38,000 --> 00:37:39,839 Speaker 2: it wanted to her to go to surgery. She wanted 668 00:37:39,880 --> 00:37:43,239 Speaker 2: to go to surgery, but the psychologist, who happens to 669 00:37:43,360 --> 00:37:47,600 Speaker 2: be person that's not like us, denied her from being 670 00:37:48,000 --> 00:37:50,920 Speaker 2: considered for that therapy. Thankfully, she was a high responder 671 00:37:50,960 --> 00:37:54,120 Speaker 2: to gop one and so no longer needed surgery. But 672 00:37:54,239 --> 00:37:57,000 Speaker 2: we're able to have this dynamic that allows her the 673 00:37:57,080 --> 00:37:58,960 Speaker 2: space and place to be wherever she needs to be 674 00:37:59,040 --> 00:38:02,160 Speaker 2: to conduct that visit. And she's done very well. She's 675 00:38:02,200 --> 00:38:04,480 Speaker 2: lost over thirty percent of her total body weight on 676 00:38:04,600 --> 00:38:12,280 Speaker 2: therapy with me, and it just feels easy and that encounter. 677 00:38:12,880 --> 00:38:15,359 Speaker 2: But here she is at Master General Hospital, this very 678 00:38:16,040 --> 00:38:19,040 Speaker 2: prominent institution where I'm sure that when she walks into 679 00:38:19,120 --> 00:38:23,239 Speaker 2: certain spaces, she's not treated in the same way that 680 00:38:23,400 --> 00:38:25,960 Speaker 2: our interaction is such that she could conduct that visit 681 00:38:26,239 --> 00:38:29,279 Speaker 2: while she's folded her sheets at the laundromat and still 682 00:38:29,400 --> 00:38:32,840 Speaker 2: get the respect and dignity that she deserves. So she's 683 00:38:32,880 --> 00:38:36,439 Speaker 2: able to have great health outcomes. And I think that's 684 00:38:37,480 --> 00:38:40,840 Speaker 2: the interaction that I want all people to have, but 685 00:38:40,960 --> 00:38:44,839 Speaker 2: particularly Black women that face so many barriers all day 686 00:38:44,880 --> 00:38:47,800 Speaker 2: every day. So hopefully that helps you understand kind of 687 00:38:47,880 --> 00:38:49,239 Speaker 2: what they actually look like. 688 00:38:49,840 --> 00:38:51,719 Speaker 1: Yeah, and I want to link back to an earlier 689 00:38:51,760 --> 00:38:54,360 Speaker 1: conversation we were having around like accessibility, right and like 690 00:38:54,400 --> 00:38:56,640 Speaker 1: the price of these medications, and we already know there 691 00:38:56,680 --> 00:38:59,719 Speaker 1: are often so many disparities in the field in terms 692 00:38:59,760 --> 00:39:02,960 Speaker 1: of access for the black community. Are you concerned that 693 00:39:03,640 --> 00:39:06,040 Speaker 1: GLP ones and the medications is going to be just 694 00:39:06,160 --> 00:39:09,759 Speaker 1: another area where we are priced out or cannot get 695 00:39:09,840 --> 00:39:11,440 Speaker 1: the services that would be really helpful. 696 00:39:12,280 --> 00:39:14,520 Speaker 2: Yes, I do think that this is an area of 697 00:39:14,640 --> 00:39:19,200 Speaker 2: significant concern. So let's use this particular woman I was 698 00:39:19,280 --> 00:39:22,160 Speaker 2: talking about. So, I happen to live in a state 699 00:39:22,320 --> 00:39:26,759 Speaker 2: where Medicaid, which is called mass health, has decided to 700 00:39:26,880 --> 00:39:30,640 Speaker 2: cover these medications, but it was only in twenty twenty three, 701 00:39:30,880 --> 00:39:34,840 Speaker 2: that these medications have come under the umbrella for coverage 702 00:39:35,480 --> 00:39:39,200 Speaker 2: for Medicaid, which are patients with lower socio economic position, 703 00:39:40,239 --> 00:39:44,000 Speaker 2: so much so that my patients with Medicaid have better 704 00:39:44,080 --> 00:39:47,800 Speaker 2: coverage than a lot of my patients that are insured 705 00:39:47,840 --> 00:39:52,919 Speaker 2: patients under private insurance employer sponsored insurance. For example, Blue 706 00:39:52,960 --> 00:39:55,120 Speaker 2: Cross Bool Shield of Massachusetts, which is one of the 707 00:39:55,239 --> 00:39:59,080 Speaker 2: largest insurers of the state, has decided as of January first, 708 00:39:59,120 --> 00:40:02,239 Speaker 2: twenty twenty six, they will not cover these medications at 709 00:40:02,280 --> 00:40:05,640 Speaker 2: all for any patients with obesity. You can imagine that 710 00:40:05,680 --> 00:40:06,840 Speaker 2: a lot of them are like, wait a minute, I 711 00:40:06,880 --> 00:40:08,799 Speaker 2: would love to get on mass Health because hey, I'm 712 00:40:08,800 --> 00:40:13,640 Speaker 2: want to be covered, and you know, you're putting patients 713 00:40:14,000 --> 00:40:16,560 Speaker 2: in a really tough predicament. Some of these patients have 714 00:40:16,640 --> 00:40:19,200 Speaker 2: been covered, they've been, you know, under this Blue Cross 715 00:40:19,239 --> 00:40:22,719 Speaker 2: Willshield of Massachusetts plan. And now as they're scrambling, they 716 00:40:22,800 --> 00:40:26,280 Speaker 2: realize January first is coming fast, and it's coming furious. 717 00:40:26,760 --> 00:40:30,879 Speaker 2: What will they do? My mass Health patients will likely 718 00:40:30,960 --> 00:40:32,640 Speaker 2: retain coverage. It took us a long time to get 719 00:40:32,680 --> 00:40:36,600 Speaker 2: them to coverage. But here again this access issue is 720 00:40:36,719 --> 00:40:41,600 Speaker 2: as a major issue. What will happen will patients health revert. 721 00:40:42,120 --> 00:40:45,439 Speaker 2: And I'm concerned that definitively this will be a major issue. 722 00:40:45,440 --> 00:40:48,320 Speaker 2: And I'm just using Massachusetts as an example for the 723 00:40:48,400 --> 00:40:51,120 Speaker 2: rest of the country. I will say that our state 724 00:40:51,200 --> 00:40:53,880 Speaker 2: tends to have better coverage than most states. I was 725 00:40:53,960 --> 00:40:57,600 Speaker 2: born and raised in Atlanta, Georgia. I know that Atlanta 726 00:40:58,760 --> 00:41:01,400 Speaker 2: tends to not to have not just Lanta, let's use 727 00:41:01,440 --> 00:41:04,760 Speaker 2: Georgia as a model, tends not to have great coverage 728 00:41:05,400 --> 00:41:09,120 Speaker 2: for these medications, whether under the private insurance model, employer's 729 00:41:09,120 --> 00:41:13,000 Speaker 2: sponsor insurance models, compared to where I currently live. And 730 00:41:13,200 --> 00:41:16,040 Speaker 2: so if I'm talking to family and friends there and 731 00:41:16,080 --> 00:41:18,600 Speaker 2: trying to guide them, they're like, gosh, I wish I 732 00:41:18,640 --> 00:41:20,759 Speaker 2: were there with you. And I'm kind of luck I 733 00:41:20,800 --> 00:41:23,600 Speaker 2: wish you were here too, But it's unfortunate. This goes 734 00:41:23,680 --> 00:41:27,440 Speaker 2: back to what's happening at the legislative level. What are 735 00:41:27,480 --> 00:41:30,200 Speaker 2: we advocating for, Going back to the question you asked 736 00:41:30,239 --> 00:41:33,840 Speaker 2: me earlier. Is it because we don't truly recognize this 737 00:41:34,160 --> 00:41:39,320 Speaker 2: as a disease. Yes, and there's so many people that 738 00:41:39,440 --> 00:41:44,120 Speaker 2: have the disease that it becomes a very expensive burden. 739 00:41:44,880 --> 00:41:47,520 Speaker 2: What if we reduce the price point for these drugs 740 00:41:47,520 --> 00:41:50,440 Speaker 2: and use like a Walmart based model, right such that 741 00:41:50,640 --> 00:41:53,120 Speaker 2: anyone that walks through that door can walk out with 742 00:41:53,280 --> 00:41:56,520 Speaker 2: something without feeling strapped for cash. And I really wish 743 00:41:56,600 --> 00:42:00,080 Speaker 2: that it were something accessible in that way, mean the 744 00:42:00,160 --> 00:42:01,120 Speaker 2: gop ones. 745 00:42:01,520 --> 00:42:05,160 Speaker 1: Yeah, And do you anticipate that as it exists longer 746 00:42:05,200 --> 00:42:07,840 Speaker 1: and there are generics available, that it is something that 747 00:42:07,960 --> 00:42:09,080 Speaker 1: becomes more accessible. 748 00:42:09,360 --> 00:42:11,680 Speaker 2: I really do, And particularly because we are going to 749 00:42:11,760 --> 00:42:15,560 Speaker 2: have more players into the space, meaning more drug companies. 750 00:42:15,680 --> 00:42:18,080 Speaker 2: Right now there are only two players. We have Novo 751 00:42:18,160 --> 00:42:22,000 Speaker 2: Nordisk and Eli Lilly, two big drugs to magnetide intracepatite 752 00:42:22,040 --> 00:42:25,480 Speaker 2: under the trade names of zempic, Wagovi, monduro zep Bound, 753 00:42:25,600 --> 00:42:27,480 Speaker 2: which is the name we haven't heard until just then. 754 00:42:28,440 --> 00:42:31,720 Speaker 2: That's all we have, right, That's period the end. Nothing 755 00:42:31,760 --> 00:42:33,520 Speaker 2: else in terms of kind of what we consider the 756 00:42:33,600 --> 00:42:37,719 Speaker 2: second generation or more highly effective medications. But we have 757 00:42:37,880 --> 00:42:40,320 Speaker 2: a lot of companies that have things in the pipeline, 758 00:42:40,360 --> 00:42:42,480 Speaker 2: and if you if you knew all of the things 759 00:42:42,520 --> 00:42:44,799 Speaker 2: in the popline, we would be here for another hour 760 00:42:44,960 --> 00:42:48,040 Speaker 2: going over all of the names. But that means that 761 00:42:48,600 --> 00:42:51,839 Speaker 2: we have more things coming into the pipeline. That means 762 00:42:51,880 --> 00:42:54,320 Speaker 2: we potentially can reduce the pists because there's more Competitors's 763 00:42:54,360 --> 00:42:56,880 Speaker 2: kind of like if you were to go to the 764 00:42:56,960 --> 00:42:59,000 Speaker 2: drug store now and go to the lotion aisle, right, 765 00:42:59,040 --> 00:43:01,560 Speaker 2: there's going to be all these differs, right they you know, 766 00:43:01,680 --> 00:43:04,680 Speaker 2: maybe there's some premium lotion, right, but you probably have 767 00:43:04,800 --> 00:43:07,120 Speaker 2: to go to Sax withth Avenue or and even Marcus 768 00:43:07,160 --> 00:43:09,320 Speaker 2: to get that. But you have all these ones and 769 00:43:09,360 --> 00:43:10,920 Speaker 2: you're going to be able to pick and they have 770 00:43:11,000 --> 00:43:13,360 Speaker 2: to price accordingly, right, because they have to compete in 771 00:43:13,440 --> 00:43:16,720 Speaker 2: that market. Similarly, I think that we'll see this drop 772 00:43:16,760 --> 00:43:20,080 Speaker 2: and price because they have to compete against each other. 773 00:43:21,520 --> 00:43:23,879 Speaker 1: Now, this may be a little bit beyond like your 774 00:43:24,120 --> 00:43:26,880 Speaker 1: specific area of expertise, but it sounds like there's also 775 00:43:27,480 --> 00:43:30,879 Speaker 1: some exciting research coming out around golp ones and their 776 00:43:30,920 --> 00:43:32,600 Speaker 1: impact on things like addictions. 777 00:43:32,800 --> 00:43:34,080 Speaker 2: I wouldn't say anything. 778 00:43:33,800 --> 00:43:37,480 Speaker 1: About I got yeah, so what's going on there? 779 00:43:38,640 --> 00:43:41,239 Speaker 2: So we talked about gop one receptors, we talked about 780 00:43:41,239 --> 00:43:43,359 Speaker 2: the brain, we talked about the gut, but we're finding 781 00:43:43,360 --> 00:43:46,480 Speaker 2: that GOLP one receptors are found throughout the body. What's 782 00:43:46,600 --> 00:43:49,080 Speaker 2: very interesting about that, particularly as you asked about addiction, 783 00:43:49,239 --> 00:43:51,800 Speaker 2: is we're finding that these medications seem to be effective 784 00:43:51,840 --> 00:43:55,640 Speaker 2: for a variety of conditions. We saw these and mice models, 785 00:43:55,680 --> 00:43:58,560 Speaker 2: So keep in mind these medications are often tested often, 786 00:43:58,680 --> 00:44:01,799 Speaker 2: let's just say, always test in mice before they make 787 00:44:01,880 --> 00:44:05,640 Speaker 2: it over to human models. So in mice we saw 788 00:44:05,840 --> 00:44:09,319 Speaker 2: that these were effective in looking at things like tobacco use, 789 00:44:09,880 --> 00:44:13,840 Speaker 2: alcohol use, other things. But we're seeing in humans similar 790 00:44:14,000 --> 00:44:16,560 Speaker 2: things happen. So patients might say to me, you know what, 791 00:44:16,760 --> 00:44:20,839 Speaker 2: doctor Stafford, I haven't wanted to drink I can't even 792 00:44:20,880 --> 00:44:23,879 Speaker 2: remember when I wanted to drink glass. We think it's 793 00:44:24,000 --> 00:44:28,480 Speaker 2: acting on some of the similar pathways for alcohol use disorder, 794 00:44:29,080 --> 00:44:32,840 Speaker 2: similarly for tobacco use disorder. But some of my physician 795 00:44:32,920 --> 00:44:36,520 Speaker 2: colleagues that work specifically in alcohol use disorder are saying 796 00:44:36,560 --> 00:44:39,319 Speaker 2: that it seems to be more effective than anything they 797 00:44:39,440 --> 00:44:44,160 Speaker 2: currently have FDA approved for the treatment of alcoholism. Now, 798 00:44:44,440 --> 00:44:46,719 Speaker 2: I will tell you that, as you know, we're in 799 00:44:46,840 --> 00:44:51,360 Speaker 2: a milieu where medical research is not being valued in 800 00:44:51,480 --> 00:44:54,839 Speaker 2: the same way as someone who conducts research and has 801 00:44:54,920 --> 00:44:57,279 Speaker 2: published over two hundred and seventy five papers. I can 802 00:44:57,360 --> 00:45:00,480 Speaker 2: tell you that I feel that directly. So a lot 803 00:45:00,560 --> 00:45:03,960 Speaker 2: of the studies that were set to start have been 804 00:45:04,680 --> 00:45:09,000 Speaker 2: halted surrounding not only looking at addiction, but also other 805 00:45:09,280 --> 00:45:14,400 Speaker 2: diseases and conditions like Alzheimer's disease, parkinsonism, issues like rheumatoid 806 00:45:14,480 --> 00:45:17,360 Speaker 2: arthritis and gout. I mean, we're seeing so many potential 807 00:45:17,600 --> 00:45:20,719 Speaker 2: use case scenarios because what these medications seem to do 808 00:45:20,920 --> 00:45:24,480 Speaker 2: is reduce inflammation throughout the body, and so we're seeing 809 00:45:24,800 --> 00:45:28,320 Speaker 2: other potential use case scenarios, not just in the addiction realm. 810 00:45:28,800 --> 00:45:33,040 Speaker 2: And I think that if we have a different regime 811 00:45:33,719 --> 00:45:37,920 Speaker 2: that allows us to consider actual science, that we potentially 812 00:45:38,000 --> 00:45:40,480 Speaker 2: can begin to learn more and more of the potential 813 00:45:40,520 --> 00:45:43,839 Speaker 2: benefits for these agents across a wide range of things, 814 00:45:43,920 --> 00:45:46,719 Speaker 2: including addiction, which we're already seeing at the point of 815 00:45:46,800 --> 00:45:49,440 Speaker 2: clinical care. Thank you for this. 816 00:45:49,640 --> 00:45:52,760 Speaker 1: So I'm hoping that we do eventually fee this research 817 00:45:52,840 --> 00:45:55,000 Speaker 1: take off, right because it sounds really important, right, Like 818 00:45:55,080 --> 00:45:56,840 Speaker 1: these are answers that people have been looking for. It 819 00:45:56,960 --> 00:45:58,040 Speaker 1: sounds like for a long time. 820 00:45:58,239 --> 00:46:01,200 Speaker 2: Yes, absolutely, So what do you feel like is. 821 00:46:01,239 --> 00:46:04,600 Speaker 1: Missing from the way that media and social platforms really 822 00:46:04,680 --> 00:46:07,680 Speaker 1: talk about things like GLP ones I. 823 00:46:07,800 --> 00:46:10,960 Speaker 2: Really want to get away from just like I said, 824 00:46:11,040 --> 00:46:14,480 Speaker 2: just thinking about weight wait wait, wait, wait, And I 825 00:46:14,520 --> 00:46:16,360 Speaker 2: don't think it's just about the number and the scale. 826 00:46:16,400 --> 00:46:20,000 Speaker 2: I think it's about the quality of weight loss. I 827 00:46:21,000 --> 00:46:23,120 Speaker 2: see this with my patients all the time. They're hyper 828 00:46:23,160 --> 00:46:24,239 Speaker 2: focused on what is the number? 829 00:46:24,280 --> 00:46:24,480 Speaker 1: Show? 830 00:46:24,560 --> 00:46:26,120 Speaker 2: What is the number? Show? What is the number? Show? 831 00:46:26,200 --> 00:46:29,520 Speaker 2: It's more about overall health benefits. And so I would 832 00:46:29,640 --> 00:46:32,879 Speaker 2: hope we shift away from just like b AMI, when 833 00:46:33,000 --> 00:46:35,040 Speaker 2: number am I supposed to be? That's a very common 834 00:46:35,120 --> 00:46:39,160 Speaker 2: conversation that I have with patients. They're like, well, am 835 00:46:39,200 --> 00:46:40,759 Speaker 2: I the right number? And I'm like, have I ever 836 00:46:40,840 --> 00:46:42,600 Speaker 2: given you a target number? So I never give my 837 00:46:42,840 --> 00:46:46,960 Speaker 2: patients to target weight. I do give them target waste orcumferences, 838 00:46:47,080 --> 00:46:50,480 Speaker 2: because if we can get that waist circumference down, then 839 00:46:50,560 --> 00:46:53,520 Speaker 2: we're going to reduce their risk of things like strokes 840 00:46:53,560 --> 00:46:55,440 Speaker 2: and heart attacks and things of that sort. And so 841 00:46:56,080 --> 00:46:58,480 Speaker 2: I would have shift away from this hyper focus on BMI, 842 00:46:58,560 --> 00:47:01,600 Speaker 2: which was never meant for us, and move them into 843 00:47:01,640 --> 00:47:05,239 Speaker 2: a more holistic consideration of looking at not only what 844 00:47:05,440 --> 00:47:08,040 Speaker 2: the weight status is, but how does that weight status 845 00:47:08,160 --> 00:47:11,000 Speaker 2: correlate to their blood sugar and their cholesterol and their 846 00:47:11,040 --> 00:47:13,600 Speaker 2: liver function tests and things of that sort. I think 847 00:47:13,640 --> 00:47:16,799 Speaker 2: this is a much more holistic manner of looking at things. 848 00:47:17,280 --> 00:47:19,200 Speaker 2: I think it's important for us to realize that when 849 00:47:19,360 --> 00:47:22,600 Speaker 2: people go on gop ones, we do lose not only fat, 850 00:47:22,640 --> 00:47:24,719 Speaker 2: but we lose muscle, and so we need to be 851 00:47:24,800 --> 00:47:26,680 Speaker 2: thinking about what are we eating and how does our 852 00:47:26,680 --> 00:47:30,040 Speaker 2: physical activity regimen look like. On these medicines, I see 853 00:47:30,120 --> 00:47:32,880 Speaker 2: that patients aren't doing exactly what I need to them 854 00:47:32,960 --> 00:47:36,040 Speaker 2: to be doing to retainly muscle. I need them to 855 00:47:36,160 --> 00:47:39,200 Speaker 2: be eating appropriate protein fiber, and I need them to 856 00:47:39,200 --> 00:47:42,680 Speaker 2: be engaging in a significant strength training regiment to really 857 00:47:42,840 --> 00:47:46,160 Speaker 2: retain as muchly muscle as possible. I would say that 858 00:47:46,280 --> 00:47:48,719 Speaker 2: both men and women don't do enough strength training. But 859 00:47:48,800 --> 00:47:51,520 Speaker 2: when I mentioned strength training to women, they are worried 860 00:47:51,560 --> 00:47:53,759 Speaker 2: about they're going to turn into the next bodybuilder to 861 00:47:53,800 --> 00:47:56,440 Speaker 2: go on Muscle and Fitness hers magazine, And I'm like, 862 00:47:56,520 --> 00:47:59,640 Speaker 2: that's not going to happen unless you start taking some 863 00:48:00,360 --> 00:48:03,640 Speaker 2: substances to really make you look a certain way. But 864 00:48:03,719 --> 00:48:05,840 Speaker 2: you're not gonna turn into a man overnight. 865 00:48:05,920 --> 00:48:19,960 Speaker 1: I promise more from our conversation after the break. So 866 00:48:20,080 --> 00:48:22,400 Speaker 1: you mentioned that your patients are sometimes looking like for 867 00:48:22,480 --> 00:48:24,719 Speaker 1: a particular weight or you know, like, oh, what number 868 00:48:24,760 --> 00:48:26,960 Speaker 1: should I be at? There is something in the field 869 00:48:27,040 --> 00:48:29,000 Speaker 1: that talks about like set point theory, right, like this 870 00:48:29,160 --> 00:48:32,879 Speaker 1: idea that your body like enjoys being at a particular size. 871 00:48:32,920 --> 00:48:33,800 Speaker 1: Can you talk about that? 872 00:48:34,600 --> 00:48:37,600 Speaker 2: Yeah, so set point theory is a really valid phenomenon. 873 00:48:37,800 --> 00:48:40,600 Speaker 2: So basically, let's look at it this way. Let's just 874 00:48:40,640 --> 00:48:43,759 Speaker 2: pick a number. Let's say your weight has gotten to 875 00:48:44,000 --> 00:48:47,840 Speaker 2: two hundred and thirty pounds, okay, and you notice that 876 00:48:48,960 --> 00:48:52,520 Speaker 2: no matter what you do, you always kind of come 877 00:48:52,640 --> 00:48:56,440 Speaker 2: back to that number. Like you may, you know, eat 878 00:48:56,520 --> 00:48:58,680 Speaker 2: during the holidays, and let's say you may go to 879 00:48:59,239 --> 00:49:01,600 Speaker 2: forty and after the holidays you kind of come back 880 00:49:01,640 --> 00:49:05,480 Speaker 2: to to thirty. Maybe you go on a diet, but 881 00:49:05,640 --> 00:49:08,000 Speaker 2: remember diet is in the word diet, that's what you're 882 00:49:08,000 --> 00:49:09,120 Speaker 2: going to diet, So we don't want to go on 883 00:49:09,160 --> 00:49:11,160 Speaker 2: a diet, right. But you go on a diet and 884 00:49:11,280 --> 00:49:12,799 Speaker 2: you go on an exercise plan, maybe you get down 885 00:49:12,800 --> 00:49:14,640 Speaker 2: to two twenty five, but somehow you come back up 886 00:49:14,800 --> 00:49:17,360 Speaker 2: to you to forty. You know, your body just seems 887 00:49:17,440 --> 00:49:20,319 Speaker 2: to always kind of teeter around it. And so if 888 00:49:20,360 --> 00:49:23,120 Speaker 2: you go and look at your weight chart over time 889 00:49:23,560 --> 00:49:26,879 Speaker 2: that you seem to vacillate around a certain number. Now 890 00:49:27,000 --> 00:49:29,839 Speaker 2: you might say, well, back when I was filling the blank. 891 00:49:29,960 --> 00:49:34,319 Speaker 2: Age high school or college, you were at a different point. 892 00:49:34,400 --> 00:49:37,359 Speaker 2: But over time, what we'll notice is that our weight 893 00:49:37,760 --> 00:49:42,239 Speaker 2: set point can shift, okay, up until about the age 894 00:49:42,280 --> 00:49:46,080 Speaker 2: of sixty to sixty five, we'll notice it starts to decline. 895 00:49:46,120 --> 00:49:48,040 Speaker 2: And at that point people are like, oh, I'm losing weight, 896 00:49:48,880 --> 00:49:51,839 Speaker 2: but not so fast. You're losing muscle. And the reason 897 00:49:51,880 --> 00:49:54,320 Speaker 2: why you're losing weight at that age is usually not 898 00:49:54,760 --> 00:49:56,959 Speaker 2: because you're losing the right kind of weight. It's because 899 00:49:56,960 --> 00:50:00,399 Speaker 2: you're losing muscle, okay. And so this idea of point 900 00:50:00,440 --> 00:50:03,200 Speaker 2: is your brain decides to defend this set point. No 901 00:50:03,320 --> 00:50:05,839 Speaker 2: matter what you do, you notice that you always kind 902 00:50:05,880 --> 00:50:10,680 Speaker 2: of come back to this particular set point or range. 903 00:50:10,800 --> 00:50:13,799 Speaker 2: It's probably more of a range set range. They set 904 00:50:13,880 --> 00:50:17,160 Speaker 2: point is their actual terminology, and you can become very 905 00:50:17,280 --> 00:50:20,200 Speaker 2: frustrated by it. And this is why people get frustrated 906 00:50:20,200 --> 00:50:22,279 Speaker 2: when they join gyms. At the beginning of the year. 907 00:50:22,760 --> 00:50:24,400 Speaker 2: They're like, gosh, I did all of that and I 908 00:50:24,480 --> 00:50:28,359 Speaker 2: lost three pounds. Are you kidding me? And so then 909 00:50:28,360 --> 00:50:32,680 Speaker 2: they stop going to the gym in like by February twentieth, 910 00:50:32,719 --> 00:50:34,880 Speaker 2: I don't know whatever date, because they're like, I just 911 00:50:34,960 --> 00:50:37,000 Speaker 2: put in all that work, and I just can't see 912 00:50:37,120 --> 00:50:40,279 Speaker 2: whatever I try, like, it just it just doesn't seem 913 00:50:40,320 --> 00:50:42,080 Speaker 2: to work for me. And so then they may need 914 00:50:42,200 --> 00:50:47,480 Speaker 2: something that's a bit more focused on addressing the underlying 915 00:50:47,600 --> 00:50:50,839 Speaker 2: disease pathology to change that set point. 916 00:50:51,840 --> 00:50:55,120 Speaker 1: Got it? Okay, So that maybe what clients are wanting 917 00:50:55,160 --> 00:50:57,279 Speaker 1: to work on as opposed to like big way. 918 00:50:57,520 --> 00:50:59,799 Speaker 2: Yes, yeah, but it's not like I said, I don't 919 00:50:59,800 --> 00:51:02,200 Speaker 2: want It's not that I don't want them to focus 920 00:51:02,239 --> 00:51:04,000 Speaker 2: on the number, because they will go in and look 921 00:51:04,080 --> 00:51:07,720 Speaker 2: up there be a MI and they'll say, well, okay, 922 00:51:07,800 --> 00:51:10,080 Speaker 2: well I'm three pounds from what it says I'm supposed 923 00:51:10,120 --> 00:51:12,239 Speaker 2: to be, or I'm five pounds. So if I give 924 00:51:12,280 --> 00:51:16,120 Speaker 2: them a target number, let's say it tells them they're 925 00:51:16,120 --> 00:51:19,120 Speaker 2: supposed to lose eighty seven pounds. Let's just come up 926 00:51:19,120 --> 00:51:24,400 Speaker 2: with this number, and let's say they lose sixty two pounds. 927 00:51:25,440 --> 00:51:28,920 Speaker 2: Let's just use that. We could say that that's pretty great, right, 928 00:51:29,880 --> 00:51:31,880 Speaker 2: But if they don't lose eighty seven, they're going to 929 00:51:31,920 --> 00:51:37,040 Speaker 2: feel like a failure. And let's say with that sixty 930 00:51:37,120 --> 00:51:40,400 Speaker 2: plus pound weight loss, their blood pressure is now normal, 931 00:51:40,680 --> 00:51:45,080 Speaker 2: their cholesterol is now normal, all of their living. Everything's 932 00:51:45,280 --> 00:51:49,600 Speaker 2: perfect in terms of like everything else, but they have 933 00:51:49,760 --> 00:51:55,719 Speaker 2: hyper focused on losing this number. I'm gonna say that 934 00:51:56,000 --> 00:51:58,880 Speaker 2: was flawed in their thinking because they feel like they 935 00:51:58,960 --> 00:52:01,520 Speaker 2: have to be this number defined by something that was 936 00:52:01,719 --> 00:52:06,080 Speaker 2: never meant for us. BMI was this concept that comes 937 00:52:06,120 --> 00:52:09,800 Speaker 2: from Aldolph to Lay, who was a Belgium statistician that 938 00:52:10,000 --> 00:52:12,839 Speaker 2: really sought to determine what was normal for Belgium white 939 00:52:12,880 --> 00:52:16,400 Speaker 2: male soldiers. I am not that you are not that, 940 00:52:17,440 --> 00:52:20,440 Speaker 2: So why are we trying to force ourselves into a 941 00:52:21,840 --> 00:52:24,279 Speaker 2: guideline that was never really meant for us to begin with? 942 00:52:26,320 --> 00:52:29,000 Speaker 1: Are there any advances in the field to move away 943 00:52:29,080 --> 00:52:31,960 Speaker 1: from BMI, because I keep hearing people say that, but 944 00:52:32,200 --> 00:52:35,239 Speaker 1: it feels like largely like the medical industry is still 945 00:52:35,320 --> 00:52:37,520 Speaker 1: using BMI. So are there alternatives? 946 00:52:37,719 --> 00:52:40,279 Speaker 2: Yeah, so the medical industry still largely uses that. But 947 00:52:40,400 --> 00:52:43,279 Speaker 2: I will tell you. On January sixteenth of twenty twenty five, 948 00:52:43,400 --> 00:52:47,160 Speaker 2: I had already happened. The Lanta Commission, which included fifty 949 00:52:47,200 --> 00:52:50,200 Speaker 2: eight commissioners, of which I am one of them, developed 950 00:52:50,239 --> 00:52:53,759 Speaker 2: a new criteria to look at obesity. We look at 951 00:52:53,880 --> 00:52:57,360 Speaker 2: something called preclinical obesity and clinical obesity where we don't 952 00:52:57,440 --> 00:53:00,920 Speaker 2: focus on BMI except for patients that do have severe obesity, 953 00:53:01,040 --> 00:53:03,920 Speaker 2: so BMI of forty plus we kept and retained the 954 00:53:04,000 --> 00:53:08,400 Speaker 2: BMI for patients that were under that. We look beneath 955 00:53:08,440 --> 00:53:11,400 Speaker 2: the hood. We start looking at your waste circumference or 956 00:53:11,440 --> 00:53:14,440 Speaker 2: waste to hip ratio. We start determining do you have 957 00:53:14,960 --> 00:53:19,400 Speaker 2: these obesity related conditions like type two diabetes, or like 958 00:53:19,480 --> 00:53:21,799 Speaker 2: the thirteen cancer is caused by OBC or all these 959 00:53:21,840 --> 00:53:25,160 Speaker 2: other things to determine more of a fuller picture of 960 00:53:25,239 --> 00:53:27,920 Speaker 2: who you are instead of just relying on one number. 961 00:53:28,920 --> 00:53:29,239 Speaker 2: Got it? 962 00:53:29,480 --> 00:53:31,480 Speaker 1: Got man? Well, thank you so much for all of 963 00:53:31,520 --> 00:53:34,720 Speaker 1: that information, Doctor Fatima. This has been so helpful. Please 964 00:53:34,800 --> 00:53:36,840 Speaker 1: let us know where can we stay in touch with you. 965 00:53:36,960 --> 00:53:38,680 Speaker 1: Do you have a website as well as any social 966 00:53:38,719 --> 00:53:39,959 Speaker 1: media channels you'd like to share? 967 00:53:40,280 --> 00:53:45,399 Speaker 2: So my website is ask ask doctor dr Fatima dot 968 00:53:45,480 --> 00:53:49,200 Speaker 2: com and all of my socials are also that so 969 00:53:49,760 --> 00:53:55,719 Speaker 2: one IgM asked doctor Fatima dot com one x which 970 00:53:55,719 --> 00:53:57,920 Speaker 2: I'd spend very little time there, but you've want to 971 00:53:58,000 --> 00:53:59,880 Speaker 2: go hang out there and that's where you like to 972 00:53:59,920 --> 00:54:03,600 Speaker 2: go is ask doctor Fatima. I'm not on Facebook, don't 973 00:54:03,640 --> 00:54:05,360 Speaker 2: plan on being there, so you guys can just go 974 00:54:05,719 --> 00:54:09,320 Speaker 2: have fun and chat with each other there. LinkedIn also 975 00:54:09,440 --> 00:54:12,759 Speaker 2: ask doctor Fatima, So feel free to come and hang 976 00:54:12,840 --> 00:54:15,440 Speaker 2: out with me. And I usually try to post on 977 00:54:15,640 --> 00:54:17,279 Speaker 2: ig and LinkedIn. I would se those where I spend 978 00:54:17,360 --> 00:54:20,520 Speaker 2: a lot of my times, and also my website and so. Yeah, 979 00:54:20,640 --> 00:54:24,640 Speaker 2: so I hope that you learned some things about obesity's disease, 980 00:54:24,680 --> 00:54:26,800 Speaker 2: what's going on in the field. The only thing I 981 00:54:26,880 --> 00:54:29,440 Speaker 2: didn't really say is I still think biatric surgery is 982 00:54:29,440 --> 00:54:33,280 Speaker 2: by far the most effective treatment for patients with severe obesity. 983 00:54:34,000 --> 00:54:36,360 Speaker 2: As I mentioned before, most of my patients with severe 984 00:54:36,400 --> 00:54:39,400 Speaker 2: obesity still require multiple modalities of therapy, and most of 985 00:54:39,440 --> 00:54:42,240 Speaker 2: them still do require the use of like a gop 986 00:54:42,400 --> 00:54:45,600 Speaker 2: one in addition to so I just don't want to 987 00:54:45,680 --> 00:54:48,239 Speaker 2: downplay that therapy, which I still think is a very 988 00:54:48,360 --> 00:54:52,759 Speaker 2: useful tool for patients with obesity, and particularly for those 989 00:54:52,840 --> 00:54:56,280 Speaker 2: with severe obesity, and I use it across the age spectrum, 990 00:54:56,680 --> 00:55:00,000 Speaker 2: from my pediatric patients to my older at ault. 991 00:55:00,600 --> 00:55:03,880 Speaker 1: So we might a physician choose to maybe start with 992 00:55:04,000 --> 00:55:06,600 Speaker 1: a golp one and see how that works versus like 993 00:55:06,760 --> 00:55:07,760 Speaker 1: bary egic surgery. 994 00:55:08,160 --> 00:55:10,560 Speaker 2: Yeah, I think that gop ones are really great for 995 00:55:10,680 --> 00:55:15,759 Speaker 2: patients with mild to moderate obesity. So patients that may 996 00:55:15,880 --> 00:55:20,000 Speaker 2: have evidence of clinical disease, they have evidence of clinical obesity, 997 00:55:20,400 --> 00:55:23,000 Speaker 2: but don't have severe disease. So once we get into 998 00:55:23,080 --> 00:55:27,680 Speaker 2: that category of having severe disease, the best treatment, hands down, 999 00:55:27,760 --> 00:55:31,320 Speaker 2: like I've mentioned, is bariatric surgery, and usually in the 1000 00:55:31,400 --> 00:55:34,680 Speaker 2: form of something we call a sleeve gas strectomy. What 1001 00:55:34,719 --> 00:55:37,719 Speaker 2: does that mean? We cut out about seventy to eighty 1002 00:55:37,760 --> 00:55:41,520 Speaker 2: percent of the stomach. But before we actually think that's 1003 00:55:41,560 --> 00:55:43,400 Speaker 2: the reason why you lose weight, it's not. The surgeons 1004 00:55:43,400 --> 00:55:45,960 Speaker 2: will tell you that at this wrong grellin, which is 1005 00:55:46,040 --> 00:55:49,880 Speaker 2: the key hunger hormone, is housed in the fundest region 1006 00:55:49,920 --> 00:55:52,279 Speaker 2: of the stomach that's cut out, and so you will 1007 00:55:52,360 --> 00:55:56,200 Speaker 2: be in this honeymoon period in that first six twelve 1008 00:55:56,239 --> 00:55:59,160 Speaker 2: months post surgery. But grell and that key hunger hormone 1009 00:55:59,200 --> 00:56:01,360 Speaker 2: is cut out, and you're like, gosh, I'm never hungry, 1010 00:56:01,440 --> 00:56:05,360 Speaker 2: this is great, this is delightful. Grellan's also housed in 1011 00:56:05,440 --> 00:56:09,480 Speaker 2: the brain. But remembering, surgeons didn't touch your brain, they 1012 00:56:09,600 --> 00:56:12,040 Speaker 2: only touch your stomach, and so you'll feel like, wait 1013 00:56:12,080 --> 00:56:15,000 Speaker 2: a minute, I think I'm hungry all of a sudden, 1014 00:56:15,640 --> 00:56:19,080 Speaker 2: So I would forewarn the patient prior to surgery. When 1015 00:56:19,200 --> 00:56:22,520 Speaker 2: that happens, when you start noticing that hunger re emerge, 1016 00:56:23,840 --> 00:56:26,160 Speaker 2: when you start noticing that you're not full as much, 1017 00:56:26,920 --> 00:56:29,759 Speaker 2: that would be when we would introduce a medication as 1018 00:56:29,840 --> 00:56:35,239 Speaker 2: an adjunct, because if not, they'll start to regain and 1019 00:56:35,400 --> 00:56:39,440 Speaker 2: that's not what we want. So, Doctor Fatima, as I 1020 00:56:39,520 --> 00:56:41,120 Speaker 2: hear you talk about some of these, I feel like 1021 00:56:41,200 --> 00:56:44,040 Speaker 2: there's something in my psychology brain that's like, yeah, but 1022 00:56:44,160 --> 00:56:46,759 Speaker 2: we kind of need hunger cues, right, Like, I feel 1023 00:56:46,800 --> 00:56:49,759 Speaker 2: like that is some of the concern you'll be hungry. No, 1024 00:56:50,080 --> 00:56:54,279 Speaker 2: you're it's not be hungry at all. You're They're like, no, 1025 00:56:54,520 --> 00:56:59,640 Speaker 2: we need those. Oh my goodness. That's very important. So 1026 00:57:00,640 --> 00:57:02,600 Speaker 2: that's part of why when we send a patient to 1027 00:57:02,680 --> 00:57:07,240 Speaker 2: burytric Surgery, there are three persons involved in that decision 1028 00:57:07,280 --> 00:57:10,200 Speaker 2: to even send them to the surgeon, someone like myself, 1029 00:57:10,239 --> 00:57:14,239 Speaker 2: an OBC medicine physician, a dietician, and we have five 1030 00:57:14,280 --> 00:57:18,920 Speaker 2: PhD level psychologists one staff. The three of us the 1031 00:57:19,040 --> 00:57:22,960 Speaker 2: tribecta with decided this patient is an appropriate person to 1032 00:57:23,080 --> 00:57:26,880 Speaker 2: see one of our five surgeons. Then they would go 1033 00:57:26,960 --> 00:57:30,440 Speaker 2: through our surgical proprim to then go to surgery. Okay, 1034 00:57:31,760 --> 00:57:34,000 Speaker 2: let's go back to that psychological piece. I appreciate that 1035 00:57:34,040 --> 00:57:36,280 Speaker 2: you're bringing that up. It's not that you don't want 1036 00:57:36,320 --> 00:57:39,960 Speaker 2: them to have any hunger, that would be inappropriate, but 1037 00:57:40,360 --> 00:57:44,760 Speaker 2: you don't understand the intensity of hunger and patients that 1038 00:57:44,920 --> 00:57:51,880 Speaker 2: often have severe disease, the preoccupation, the thinking like hmm, 1039 00:57:52,000 --> 00:57:54,840 Speaker 2: I'm in the middle of this taping, I'm thinking about 1040 00:57:55,080 --> 00:57:57,360 Speaker 2: eating right now, as opposed to being focused on what 1041 00:57:57,520 --> 00:58:00,880 Speaker 2: you're saying. I can be hungry, that's one thing, but 1042 00:58:00,920 --> 00:58:03,960 Speaker 2: I'm so preoccupied that I'm I'm like, hmm, I should 1043 00:58:03,960 --> 00:58:06,720 Speaker 2: be thinking about that as opposed to like answering the question. 1044 00:58:07,520 --> 00:58:09,200 Speaker 2: And I'm thinking about not only for me, but I'm 1045 00:58:09,200 --> 00:58:11,200 Speaker 2: also thinking about for my family, and then by the suit, 1046 00:58:11,240 --> 00:58:13,160 Speaker 2: and then I'm thinking about this, and then that could 1047 00:58:13,200 --> 00:58:16,680 Speaker 2: be how pervasive it is. But when it starts to merge, 1048 00:58:16,760 --> 00:58:20,080 Speaker 2: they sense this, and it may be part of like 1049 00:58:20,240 --> 00:58:23,640 Speaker 2: binge eating, which is the most common eating disorder associated 1050 00:58:23,720 --> 00:58:27,360 Speaker 2: for patients with obesity. There's a high overlap bengating disorder 1051 00:58:27,440 --> 00:58:30,000 Speaker 2: with patients with obesity. It may not even be that, 1052 00:58:30,320 --> 00:58:32,680 Speaker 2: it may just be that they start to notice it emerge, 1053 00:58:32,720 --> 00:58:34,840 Speaker 2: but as that starts to merge, it will continue to 1054 00:58:35,000 --> 00:58:39,720 Speaker 2: cause weight shifts over time. If loss weight usually come 1055 00:58:39,760 --> 00:58:42,240 Speaker 2: to a point of wastability. If I don't treat it, 1056 00:58:42,800 --> 00:58:46,040 Speaker 2: there will be the weight regain and it will be 1057 00:58:46,080 --> 00:58:48,680 Speaker 2: a shame for me to send them to surgery only 1058 00:58:48,720 --> 00:58:50,479 Speaker 2: for them to regain all of the weight. 1059 00:58:51,520 --> 00:58:54,400 Speaker 1: Got it, Okay, So it doesn't completely take away the 1060 00:58:54,480 --> 00:58:56,760 Speaker 1: hunger keys. It's like you mentioned turning down the volume 1061 00:58:56,840 --> 00:58:57,400 Speaker 1: the intensity. 1062 00:58:57,520 --> 00:58:59,640 Speaker 2: Yes, on exactly. So, yeah, we don't want them to 1063 00:58:59,760 --> 00:59:02,560 Speaker 2: not eat right. That would be inhumane, right, you know, 1064 00:59:02,680 --> 00:59:05,400 Speaker 2: we want them to be human. But as soon as 1065 00:59:05,440 --> 00:59:06,800 Speaker 2: they start, are like, well wait a minute, Nope, this 1066 00:59:06,960 --> 00:59:08,840 Speaker 2: is abnormal. They're eating right, because I want to know 1067 00:59:08,880 --> 00:59:12,480 Speaker 2: what breakfast, snack, lunch, snack, dinner snack is. If they 1068 00:59:12,520 --> 00:59:15,320 Speaker 2: tell me nothing in any of those, we got a problem, right. 1069 00:59:16,160 --> 00:59:19,520 Speaker 2: But if they are telling me, now I'm noticing, oh gosh, 1070 00:59:19,560 --> 00:59:21,760 Speaker 2: I need that second snack, and then I need the third. Ooh, 1071 00:59:21,800 --> 00:59:26,200 Speaker 2: I'm noticing something's not right. Something's just not right. We 1072 00:59:26,440 --> 00:59:28,760 Speaker 2: need to start thinking about it. Now. There's something that'll 1073 00:59:28,760 --> 00:59:31,040 Speaker 2: resist They're like, no, I'm gonna use that willpower. Going 1074 00:59:31,040 --> 00:59:34,000 Speaker 2: back to that question you asked me, I'm growing down. 1075 00:59:34,560 --> 00:59:37,520 Speaker 2: I'm gonna go on that third walk and then you're 1076 00:59:37,560 --> 00:59:40,000 Speaker 2: like you just go on, like two wats I'm gonna go. 1077 00:59:40,120 --> 00:59:44,800 Speaker 2: I'm gonna I'm gonna push harder, and you're like, why, 1078 00:59:44,880 --> 00:59:47,120 Speaker 2: I can help you. I can help you, right, it's 1079 00:59:47,200 --> 00:59:49,400 Speaker 2: the biology that's causing you to do that way. I 1080 00:59:49,440 --> 00:59:52,680 Speaker 2: can help the biology if I can get the right tools, right, 1081 00:59:52,720 --> 00:59:55,320 Speaker 2: because not everyone we just talked about is access to 1082 00:59:55,480 --> 00:59:58,360 Speaker 2: those tools. And then they're like, you can imagine like 1083 00:59:58,440 --> 01:00:03,320 Speaker 2: it's a sense of calm. I get the two I dodged. 1084 01:00:03,400 --> 01:00:07,200 Speaker 2: I dodged a bullet there. Wow. Thanks, I thank you 1085 01:00:07,320 --> 01:00:09,160 Speaker 2: do share for a while. You were right. I do 1086 01:00:09,320 --> 01:00:12,520 Speaker 2: feel I feel back to how I felt some patients would, 1087 01:00:12,560 --> 01:00:15,400 Speaker 2: particularly those post op patients. Oh, I feel back to 1088 01:00:15,480 --> 01:00:19,560 Speaker 2: how I felt after surgery. Now I feel I feel 1089 01:00:19,600 --> 01:00:22,280 Speaker 2: that again, you know, so something like that. 1090 01:00:22,680 --> 01:00:24,120 Speaker 1: Thank you for that doctor of her team, and I 1091 01:00:24,160 --> 01:00:25,960 Speaker 1: appreciate you spending some time with day. 1092 01:00:26,480 --> 01:00:28,920 Speaker 2: Absolutely, it's been a delight. I just want people to 1093 01:00:29,000 --> 01:00:30,000 Speaker 2: have the right information. 1094 01:00:30,640 --> 01:00:38,400 Speaker 1: Thank you. I'm so glad doctor Stanford was able to 1095 01:00:38,520 --> 01:00:42,040 Speaker 1: join us for today's conversation. Her compassionate approach to this 1096 01:00:42,160 --> 01:00:44,720 Speaker 1: work and commitment to changing how we understand weight and 1097 01:00:44,840 --> 01:00:48,240 Speaker 1: health is truly inspiring. To learn more about her work, 1098 01:00:48,480 --> 01:00:50,360 Speaker 1: be sure to visit our show notes at Therapy for 1099 01:00:50,440 --> 01:00:53,960 Speaker 1: Blackgirls dot com slash Session four two six, and don't 1100 01:00:53,960 --> 01:00:55,840 Speaker 1: forget to text two of your girls right now and 1101 01:00:55,920 --> 01:00:58,120 Speaker 1: tell them to check out the episode. Did you know 1102 01:00:58,160 --> 01:01:00,320 Speaker 1: you could leave us a voicemail with your question are 1103 01:01:00,320 --> 01:01:04,320 Speaker 1: suggestions for the podcast. Whether you have ideas for future topics, 1104 01:01:04,480 --> 01:01:07,439 Speaker 1: book or movie suggestions, or just something on your mind, 1105 01:01:07,520 --> 01:01:09,880 Speaker 1: we'd love to hear it. Head on over to Memo 1106 01:01:09,960 --> 01:01:12,560 Speaker 1: dot fm slash Therapy for Black Girls and leave us 1107 01:01:12,600 --> 01:01:15,640 Speaker 1: a voice meil. If you're looking for a therapist in 1108 01:01:15,720 --> 01:01:18,560 Speaker 1: your area, check out our therapist directory at Therapy for 1109 01:01:18,640 --> 01:01:22,240 Speaker 1: Blackgirls dot com slash directory, and don't forget to follow 1110 01:01:22,360 --> 01:01:25,640 Speaker 1: us over on Instagram at Therapy for Black Girls. You 1111 01:01:25,720 --> 01:01:28,880 Speaker 1: can also support the podcast by joining our Patreon community. 1112 01:01:29,440 --> 01:01:32,440 Speaker 1: When you join, you'll get access to exclusive content, behind 1113 01:01:32,440 --> 01:01:35,720 Speaker 1: the scenes updates, and monthly Q and A sessions. Come 1114 01:01:35,760 --> 01:01:37,920 Speaker 1: on over and join us at community dot Therapy for 1115 01:01:38,000 --> 01:01:41,880 Speaker 1: Blackgirls dot com. We love to have you. This episode 1116 01:01:42,000 --> 01:01:45,880 Speaker 1: was produced by Elise Ellis, Indietubu and Tyree Rush. Editing 1117 01:01:46,000 --> 01:01:48,840 Speaker 1: was done by Dennison Bradford. Thank y'all so much for 1118 01:01:48,960 --> 01:01:51,760 Speaker 1: joining me again this week. I look forward to continuing 1119 01:01:51,800 --> 01:01:52,920 Speaker 1: this conversation. 1120 01:01:52,600 --> 01:01:55,120 Speaker 2: With you all real scene, take good care. 1121 01:02:00,080 --> 01:02:00,120 Speaker 1: What