WEBVTT - Ep 13 Don't Tread on my Monkshood: Crossover w/ IDOP

0:00:14.960 --> 0:00:18.959
<v Speaker 1>Hi, and welcome to this podcast Will Kill You Crossover Edition.

0:00:22.280 --> 0:00:25.480
<v Speaker 2>I'm Aaron Welsh and I'm eron Aman Updank and this.

0:00:25.480 --> 0:00:27.840
<v Speaker 1>Week we are joined by our good friend and fellow

0:00:27.880 --> 0:00:29.640
<v Speaker 1>podcaster Matt Kindaeus.

0:00:30.040 --> 0:00:33.720
<v Speaker 3>Say Hi, Matt, Hi, Matt, I should never have done that.

0:00:35.200 --> 0:00:36.440
<v Speaker 3>I'm ashamed of myself already.

0:00:36.640 --> 0:00:39.839
<v Speaker 1>No, it's perfect. So Matt is a fellow grad student

0:00:40.000 --> 0:00:44.320
<v Speaker 1>and host of the incredible podcast In Defensive Plants. You, Matt,

0:00:44.360 --> 0:00:46.840
<v Speaker 1>can you introduce yourself a bit and talk a little

0:00:46.880 --> 0:00:48.400
<v Speaker 1>bit about what your podcast does.

0:00:48.680 --> 0:00:52.000
<v Speaker 3>Yeah, I'm Matt Candeis and I host In Defensive Plants.

0:00:52.520 --> 0:00:56.040
<v Speaker 3>It is a weekly podcast that essentially is there to

0:00:56.160 --> 0:00:58.640
<v Speaker 3>cure what we call plant blindness. And by we, I

0:00:58.680 --> 0:01:00.800
<v Speaker 3>just mean people that like plants.

0:01:01.400 --> 0:01:02.600
<v Speaker 1>We suffer from plant line.

0:01:02.640 --> 0:01:05.240
<v Speaker 3>Yeah, a lot of the world does. And it's not

0:01:05.280 --> 0:01:07.880
<v Speaker 3>a fault. It's just the way our species is programmed.

0:01:07.959 --> 0:01:11.360
<v Speaker 3>But that's why the podcast exists, and I think that's

0:01:11.400 --> 0:01:14.240
<v Speaker 3>the niche it's feeling, is to celebrate plants and get

0:01:14.240 --> 0:01:16.640
<v Speaker 3>people excited, maybe not obsessed. You don't have to become

0:01:16.680 --> 0:01:20.840
<v Speaker 3>obsessed with them, but excitement and just appreciate the botanical

0:01:20.840 --> 0:01:23.520
<v Speaker 3>world because really we wouldn't be here without it, So.

0:01:23.880 --> 0:01:24.880
<v Speaker 2>Yeah, that's very true.

0:01:24.959 --> 0:01:27.000
<v Speaker 1>It's awesome, and everyone go and check it out in

0:01:27.080 --> 0:01:28.040
<v Speaker 1>Defensive Plants.

0:01:28.280 --> 0:01:32.039
<v Speaker 2>Well, especially because we're there's going to be another episode, yes,

0:01:32.920 --> 0:01:33.640
<v Speaker 2>that will.

0:01:33.440 --> 0:01:36.160
<v Speaker 3>Exist, because this is a crossover.

0:01:35.800 --> 0:01:38.760
<v Speaker 1>Cross a reciprocal transplant where we're.

0:01:38.560 --> 0:01:39.840
<v Speaker 2>Going to be on that podcast.

0:01:39.840 --> 0:01:42.880
<v Speaker 3>That's what I do, that's what I study.

0:01:43.440 --> 0:01:47.039
<v Speaker 1>So Matt's joining us this week and then upcoming we

0:01:47.120 --> 0:01:52.120
<v Speaker 1>will be joining Matt on his podcast to talk about.

0:01:51.120 --> 0:01:52.720
<v Speaker 2>Herbal lism things.

0:01:53.160 --> 0:01:56.480
<v Speaker 3>Yeah. Yeah, So there's a lot of i'll call it

0:01:56.600 --> 0:02:00.840
<v Speaker 3>mysticism and folklore surrounding herbal remedies. And though I'm not

0:02:01.280 --> 0:02:03.800
<v Speaker 3>a practicing herbalist, I know there's merit to some and

0:02:03.840 --> 0:02:07.240
<v Speaker 3>a lot of misinformation about others. So who better to

0:02:07.240 --> 0:02:11.120
<v Speaker 3>bring on than some disease ecologists to talk about the

0:02:11.120 --> 0:02:13.360
<v Speaker 3>wild world of plant medicinals.

0:02:13.400 --> 0:02:19.320
<v Speaker 1>So totally in our wheelhouse. We're gonna try, we'll research it.

0:02:19.480 --> 0:02:21.560
<v Speaker 3>Yeah, we're smart people.

0:02:21.360 --> 0:02:27.440
<v Speaker 2>Right, Yeah, exactly, that's literally our job. So Matt is

0:02:27.440 --> 0:02:31.240
<v Speaker 2>here because this week, as we said, we're doing something

0:02:31.280 --> 0:02:35.320
<v Speaker 2>a little bit different. This is part one of a

0:02:35.360 --> 0:02:42.760
<v Speaker 2>crossover series on poison. We have at least a four

0:02:42.760 --> 0:02:45.760
<v Speaker 2>part series I feel like we could expand it eventually too. Yeah,

0:02:45.840 --> 0:02:48.480
<v Speaker 2>but at a minimum, you've got a four part series

0:02:49.000 --> 0:02:51.080
<v Speaker 2>and each week we're going to talk about a different

0:02:51.240 --> 0:02:55.040
<v Speaker 2>poisonous plant. It's used throughout human history, the effects it

0:02:55.080 --> 0:02:58.840
<v Speaker 2>actually has on your body, and then the evolutionary ecology

0:02:58.880 --> 0:03:01.639
<v Speaker 2>of the plant, meaning why does it produce the compounds

0:03:01.639 --> 0:03:02.360
<v Speaker 2>that make you sick.

0:03:03.000 --> 0:03:04.800
<v Speaker 1>It's gonna be super duper fun.

0:03:04.919 --> 0:03:08.160
<v Speaker 3>Yeah, I'm so pumped. Yeah, I can't even contain. Like,

0:03:08.200 --> 0:03:10.200
<v Speaker 3>we were messaging back and forth about this and I

0:03:10.520 --> 0:03:14.360
<v Speaker 3>was like, I'm like, yes, I know.

0:03:14.639 --> 0:03:16.400
<v Speaker 1>It was really hard to not go, oh my gosh,

0:03:16.480 --> 0:03:18.560
<v Speaker 1>I guess I just learned. You have to know about this.

0:03:19.160 --> 0:03:21.800
<v Speaker 1>It's so cool. Yeah, so very exciting.

0:03:22.040 --> 0:03:26.280
<v Speaker 3>This allows me to stretch some muscles that I don't

0:03:26.360 --> 0:03:29.440
<v Speaker 3>ever get to stretch. It's it's not a wheelhouse, I frequent.

0:03:29.560 --> 0:03:32.320
<v Speaker 3>So thanks being open to this idea.

0:03:32.440 --> 0:03:32.960
<v Speaker 2>I love it.

0:03:33.120 --> 0:03:37.320
<v Speaker 1>We're pumped. Okay, So, because this is an episode of

0:03:37.360 --> 0:03:40.520
<v Speaker 1>this podcast, will kill you. Guess what we have.

0:03:40.720 --> 0:03:44.320
<v Speaker 2>A quarantine any time? A quarantiney time.

0:03:45.560 --> 0:03:46.840
<v Speaker 1>What do we have this week?

0:03:47.040 --> 0:03:50.800
<v Speaker 2>This week we're drinking the wolf Spin potion. Yeah, because

0:03:50.800 --> 0:03:52.200
<v Speaker 2>we're talking about what plant.

0:03:52.720 --> 0:03:58.920
<v Speaker 3>Well, it's a bunch of plants, but monkshood essentially in

0:03:58.960 --> 0:04:00.640
<v Speaker 3>the genus acnodum.

0:04:01.040 --> 0:04:03.960
<v Speaker 1>Fabulous, which also contains the plant wolf spain, right, or

0:04:04.000 --> 0:04:04.960
<v Speaker 1>is that a different plant?

0:04:05.600 --> 0:04:06.760
<v Speaker 3>Well? Was it the same plant?

0:04:06.840 --> 0:04:08.000
<v Speaker 2>Plant blindness at work?

0:04:08.120 --> 0:04:11.440
<v Speaker 3>Yeah, first, lesson common names are are kind of a

0:04:11.480 --> 0:04:14.800
<v Speaker 3>pain In the end, a lot of plants can be

0:04:14.800 --> 0:04:17.680
<v Speaker 3>called the same thing and be called many different things

0:04:17.920 --> 0:04:21.200
<v Speaker 3>throughout different cultures. So essentially this is in the buttercup family.

0:04:21.240 --> 0:04:23.080
<v Speaker 3>So the best example is a buttercup in the United

0:04:23.080 --> 0:04:28.760
<v Speaker 3>States is different than a buttercup in England. But when

0:04:28.800 --> 0:04:31.719
<v Speaker 3>you say wolf spain, you're generally referring to a group

0:04:31.760 --> 0:04:34.680
<v Speaker 3>of plants in the genus acnodum. Or the monk SAIDs.

0:04:34.640 --> 0:04:38.599
<v Speaker 1>Okay, fabulous, awesome. So but what is in the wolf

0:04:38.600 --> 0:04:43.320
<v Speaker 1>Spain potion this week? Yeah? Is it's basically an aviation Yeah,

0:04:43.360 --> 0:04:45.320
<v Speaker 1>which if you haven't heard of it, it's a really

0:04:45.320 --> 0:04:46.440
<v Speaker 1>delicious drink.

0:04:46.600 --> 0:04:49.320
<v Speaker 2>It's purple, it's beautiful, it's geuz.

0:04:50.880 --> 0:04:52.440
<v Speaker 3>I just thought we could nail the jakes too.

0:04:52.440 --> 0:04:59.440
<v Speaker 1>But yeah, and and so we'll post the recipe and

0:04:59.480 --> 0:05:02.000
<v Speaker 1>all that online along with some cool pictures.

0:05:02.279 --> 0:05:06.120
<v Speaker 2>So what are chills we do need?

0:05:07.400 --> 0:05:10.120
<v Speaker 1>Clink? There we go it was an okay sound, it

0:05:10.160 --> 0:05:27.280
<v Speaker 1>wasn't quite crystal. But you know, now that that's out

0:05:27.279 --> 0:05:32.800
<v Speaker 1>of the way, yep. Intro is over, I'll get started.

0:05:33.440 --> 0:05:36.000
<v Speaker 1>So since we're doing a four parter on this topic,

0:05:36.240 --> 0:05:38.680
<v Speaker 1>I figured I would kind of split the history of

0:05:38.800 --> 0:05:44.400
<v Speaker 1>poisons into four parts, so Ancient, Middle Ages, Victorian, and modern.

0:05:44.800 --> 0:05:46.680
<v Speaker 1>I don't know if that's going to be how it

0:05:46.800 --> 0:05:48.920
<v Speaker 1>ends up being. The boundaries are a little bit fluid,

0:05:49.080 --> 0:05:52.040
<v Speaker 1>but in any case, this week I'll be talking about

0:05:52.120 --> 0:05:55.240
<v Speaker 1>the ancient history of poisons, So who first decided to

0:05:55.360 --> 0:05:58.400
<v Speaker 1>use them, how were they used, what was their reputation?

0:05:59.040 --> 0:06:01.960
<v Speaker 1>And then I'm going to talk specifically about the history

0:06:02.040 --> 0:06:06.039
<v Speaker 1>of the chosen poison of the week wolf Spain aka Aconite,

0:06:06.080 --> 0:06:10.320
<v Speaker 1>aka Monkshood, et cetera. Turns out this beauty is not

0:06:10.560 --> 0:06:13.760
<v Speaker 1>just the name of the werewolf Preventative and Harry Potter

0:06:14.640 --> 0:06:19.159
<v Speaker 1>and are quarantiny. So what's the difference between a physician,

0:06:19.640 --> 0:06:23.840
<v Speaker 1>a pretender, a magician and a poisoner? Ooh, The answer

0:06:23.960 --> 0:06:28.320
<v Speaker 1>is that it depends. Those lines have always been blurred

0:06:28.360 --> 0:06:31.200
<v Speaker 1>in the history of medicine and medicinal plants, many of

0:06:31.200 --> 0:06:34.000
<v Speaker 1>which have a dual nature of healing. And harm, and

0:06:34.040 --> 0:06:37.120
<v Speaker 1>those lines continue to be blurred in modern times, which

0:06:37.160 --> 0:06:39.559
<v Speaker 1>is something we'll get to talk a lot more about

0:06:39.680 --> 0:06:44.320
<v Speaker 1>in the herbal Medicine crossover episode. Yeah, but this week

0:06:44.360 --> 0:06:47.360
<v Speaker 1>we're here to talk about poisons. The poisons have been

0:06:47.400 --> 0:06:50.080
<v Speaker 1>around for I thought this was really cool, all of

0:06:50.160 --> 0:06:55.680
<v Speaker 1>written human history dang d so Yeah, and also probably

0:06:56.040 --> 0:06:57.440
<v Speaker 1>millennia before.

0:06:57.120 --> 0:07:01.080
<v Speaker 3>That, I wouldn't done it. Yeah, I mean, you got

0:07:01.120 --> 0:07:05.120
<v Speaker 3>to respect the fact that there's something there in human nature.

0:07:05.160 --> 0:07:07.640
<v Speaker 3>You don't just invent writing and then start poisoning people.

0:07:08.680 --> 0:07:11.880
<v Speaker 1>Yeah, exactly. That's the really interesting part because like, in

0:07:12.000 --> 0:07:15.240
<v Speaker 1>order to determine what plants are poisonous, what plants are

0:07:15.440 --> 0:07:19.640
<v Speaker 1>are helpful, what plants are food, it's going to involve

0:07:19.680 --> 0:07:22.160
<v Speaker 1>a lot of trial and error, a lot of barfing,

0:07:22.800 --> 0:07:27.800
<v Speaker 1>a lot of numb mouths, hallucinations and death along the way, and.

0:07:28.120 --> 0:07:34.400
<v Speaker 3>A big plug for rampant Diary.

0:07:32.160 --> 0:07:41.520
<v Speaker 1>I can't believe, thank you. How is anyone alive? Really

0:07:41.560 --> 0:07:45.160
<v Speaker 1>the big question. Imagine that you're one of those early humans.

0:07:45.760 --> 0:07:48.400
<v Speaker 1>You can't resort to Google like you can nowadays to

0:07:48.440 --> 0:07:52.640
<v Speaker 1>tell you everything about a plant. You can't just watch

0:07:52.680 --> 0:07:54.920
<v Speaker 1>what you eat, but you have to remember how it

0:07:54.960 --> 0:07:58.200
<v Speaker 1>made you feel, and you didn't just rely on firsthand

0:07:58.200 --> 0:08:00.840
<v Speaker 1>experience for this knowledge. If you saw a cluster of

0:08:00.960 --> 0:08:04.320
<v Speaker 1>dead birds or foxes or something next to a bush

0:08:04.360 --> 0:08:07.000
<v Speaker 1>filled with red berries, maybe you'd make a note not

0:08:07.040 --> 0:08:11.760
<v Speaker 1>to keep those berries. We would hope, we yeah, one

0:08:11.840 --> 0:08:14.520
<v Speaker 1>would hope and yeah. And then also, you know, if

0:08:14.560 --> 0:08:17.720
<v Speaker 1>a friend told you about a digestive experience after feasting

0:08:17.800 --> 0:08:20.240
<v Speaker 1>on a new salad creation, maybe you'd ask them to

0:08:20.280 --> 0:08:23.000
<v Speaker 1>point out which plants they use, just like which taco

0:08:23.040 --> 0:08:26.160
<v Speaker 1>bells to avoid, because there are good ones and bad ones,

0:08:26.240 --> 0:08:28.480
<v Speaker 1>and the answers you should avoid them all. Yeah, I

0:08:28.520 --> 0:08:30.239
<v Speaker 1>mean we're.

0:08:30.120 --> 0:08:34.640
<v Speaker 3>Weak, yes, yeah.

0:08:34.679 --> 0:08:38.280
<v Speaker 1>And before written language, this knowledge couldn't be stored in

0:08:38.360 --> 0:08:40.640
<v Speaker 1>physical form. It had to be disseminated in a much

0:08:40.640 --> 0:08:43.959
<v Speaker 1>different way through storytelling, from one village to another, from

0:08:43.960 --> 0:08:47.240
<v Speaker 1>one generation to the next. And slowly this knowledge spread.

0:08:47.600 --> 0:08:51.320
<v Speaker 1>But one person's knowledge is another person's weapon, and it

0:08:51.360 --> 0:08:55.400
<v Speaker 1>wouldn't have been long before someone would have snuck some

0:08:55.440 --> 0:08:59.360
<v Speaker 1>parsley looking hemlock into their rivals side salad. The first

0:08:59.400 --> 0:09:02.120
<v Speaker 1>written record words we have of the use of poisons

0:09:02.160 --> 0:09:04.959
<v Speaker 1>comes from just a little bit after writing itself was

0:09:05.000 --> 0:09:08.640
<v Speaker 1>thought to be invented so around five thousand years ago. Wow,

0:09:09.280 --> 0:09:12.440
<v Speaker 1>And we see around that time descriptions of poisonous and

0:09:12.520 --> 0:09:15.440
<v Speaker 1>medicinal plants pop up all over around the same time,

0:09:15.440 --> 0:09:18.640
<v Speaker 1>which is kind of weird in Egyptian papyri, Chinese and

0:09:18.679 --> 0:09:21.359
<v Speaker 1>Indian texts, and Mesopotamian clay tablets.

0:09:21.760 --> 0:09:24.280
<v Speaker 3>I mean, is it weird or is it just humans

0:09:24.280 --> 0:09:27.040
<v Speaker 3>were doing that? And then they well, we might as

0:09:27.080 --> 0:09:27.920
<v Speaker 3>well write this down.

0:09:28.120 --> 0:09:30.600
<v Speaker 1>Well, and like what's more important than like we we

0:09:30.640 --> 0:09:33.040
<v Speaker 1>need to eat every day a certain amount. We need

0:09:33.080 --> 0:09:34.480
<v Speaker 1>to eat the things that we collect.

0:09:34.679 --> 0:09:36.320
<v Speaker 2>And this is how you kill your enemies.

0:09:36.760 --> 0:09:37.559
<v Speaker 1>Well, and this is.

0:09:37.520 --> 0:09:41.719
<v Speaker 3>How you mean there's two families and enough food to

0:09:41.720 --> 0:09:42.560
<v Speaker 3>support one of them.

0:09:42.720 --> 0:09:47.600
<v Speaker 1>Yeah, so sorry, you guys are going straight to the

0:09:47.679 --> 0:09:52.760
<v Speaker 1>how to poison someone's section of that tablet, so our heads,

0:09:53.040 --> 0:09:58.720
<v Speaker 1>I mean yeah so. And also, poisons featured prominently in

0:09:58.800 --> 0:10:02.480
<v Speaker 1>Greek and Roman mythology, where it seems like the reputation

0:10:02.640 --> 0:10:06.360
<v Speaker 1>of poison as a woman's weapon had taken hold, which

0:10:06.400 --> 0:10:10.480
<v Speaker 1>is really fun. So Dianeira, the second wife of Heracles

0:10:10.600 --> 0:10:14.760
<v Speaker 1>aka Hercules, killed him with a poisoned shirt for being

0:10:14.880 --> 0:10:20.720
<v Speaker 1>unfaithful to her deserved it. Yeah, file that under stuff

0:10:20.760 --> 0:10:24.319
<v Speaker 1>Disney left out of the movie, along with the fact

0:10:24.360 --> 0:10:27.600
<v Speaker 1>that Hercules driven mad by Hara I Love I Love like.

0:10:27.840 --> 0:10:32.320
<v Speaker 1>Disney did not tell you Hercules killed his first wife

0:10:32.320 --> 0:10:36.679
<v Speaker 1>and children as you do. We'll get to that leader anyway.

0:10:37.200 --> 0:10:40.720
<v Speaker 1>Side note hercules second wife, the one who killed him.

0:10:41.000 --> 0:10:46.480
<v Speaker 1>Her name Dianira means man destroyer or destroyer of her husband.

0:10:46.640 --> 0:10:48.840
<v Speaker 2>Okay, if I ever have kids, that's their name.

0:10:50.760 --> 0:10:55.280
<v Speaker 1>Also in the Odyssey, Circe, which you know, she's got

0:10:55.320 --> 0:10:58.680
<v Speaker 1>to be evil, right, we know everything, a goddess of

0:10:58.760 --> 0:11:02.359
<v Speaker 1>magic uses mind altering drugs to turn all of Odysseus's

0:11:02.400 --> 0:11:06.240
<v Speaker 1>men into pigs. Although to what end I have no idea.

0:11:06.720 --> 0:11:08.640
<v Speaker 2>Just for fun, I'm bacon.

0:11:08.920 --> 0:11:11.400
<v Speaker 1>I don't know. It's really weird though, yeah, I couldn't

0:11:11.400 --> 0:11:15.559
<v Speaker 1>find a reason for that. But jumping from myth into history,

0:11:15.640 --> 0:11:18.240
<v Speaker 1>we see poisons play a huge role in the legal

0:11:18.240 --> 0:11:22.040
<v Speaker 1>and political system of ancient Rome, which isn't as boring

0:11:22.200 --> 0:11:26.480
<v Speaker 1>as it may sound. Poisons were widely used to carry

0:11:26.480 --> 0:11:29.840
<v Speaker 1>out death sentences, and that's what happened with the famous

0:11:29.840 --> 0:11:35.120
<v Speaker 1>philosophers Socrates. So he was convicted of moral corruption and impiety,

0:11:35.320 --> 0:11:39.160
<v Speaker 1>and he was ordered to drink a hemlock infusion, and

0:11:39.160 --> 0:11:41.840
<v Speaker 1>there's great paintings of this. There's one where he's like

0:11:42.559 --> 0:11:45.600
<v Speaker 1>angrily in a I don't know bath sheet or toga.

0:11:45.720 --> 0:11:47.520
<v Speaker 3>I assume same difference.

0:11:47.720 --> 0:11:51.760
<v Speaker 1>I mean, my experience with toga is frat party only,

0:11:51.800 --> 0:11:54.240
<v Speaker 1>so yeah, it's gotta be a bath shoot. Yeah. Yeah,

0:11:54.280 --> 0:11:56.240
<v Speaker 1>So I'll post some of those paintings because they're really fun.

0:11:56.280 --> 0:11:56.920
<v Speaker 2>That's amazing.

0:11:57.080 --> 0:11:59.240
<v Speaker 1>But from this time, which is around three hundred and

0:11:59.320 --> 0:12:06.040
<v Speaker 1>ninety nine beasts see around that exact date, poisons seemed

0:12:06.080 --> 0:12:10.359
<v Speaker 1>to become increasingly popular in ancient Rome. The Hippocratic oath.

0:12:10.840 --> 0:12:12.840
<v Speaker 2>And I'm looking at you Someday.

0:12:12.920 --> 0:12:17.320
<v Speaker 1>Written around then, includes the phrase neither will I administer

0:12:17.440 --> 0:12:20.280
<v Speaker 1>a poison to anybody when asked to do so, nor

0:12:20.320 --> 0:12:24.360
<v Speaker 1>will I suggest such a course. Interesting. Yeah, it's pretty

0:12:24.360 --> 0:12:28.400
<v Speaker 1>clear that poisoning was a problem in physicians.

0:12:28.960 --> 0:12:31.280
<v Speaker 3>But even then it goes back to what you originally

0:12:31.320 --> 0:12:32.839
<v Speaker 3>said about blurred lines.

0:12:32.520 --> 0:12:37.040
<v Speaker 2>Right, I mean, how do you define meety poisonous?

0:12:37.120 --> 0:12:42.440
<v Speaker 1>But it is it intent defines the poison.

0:12:42.600 --> 0:12:44.960
<v Speaker 2>Really, this is philosophy question.

0:12:45.120 --> 0:12:52.040
<v Speaker 1>I mean, too bad. Socrates was killed by a poison. Galen,

0:12:52.240 --> 0:12:56.160
<v Speaker 1>who was another famous Greek physician and scholar, instructed doctors

0:12:56.200 --> 0:13:00.160
<v Speaker 1>to collect herbs and prepare potions themselves rather than bying

0:13:00.200 --> 0:13:02.320
<v Speaker 1>them at the market, where one plant could be sold

0:13:02.400 --> 0:13:06.280
<v Speaker 1>under the wrong name, leading to a deadly quote mistake,

0:13:07.440 --> 0:13:12.280
<v Speaker 1>and to protect themselves. Also, the wealthy hired tasters, which

0:13:12.320 --> 0:13:14.280
<v Speaker 1>is one of the odder status symbols.

0:13:14.360 --> 0:13:17.920
<v Speaker 2>They like to taste their food, right, Yeah.

0:13:17.400 --> 0:13:20.640
<v Speaker 1>So it became such a popular practice that there grew

0:13:20.679 --> 0:13:24.040
<v Speaker 1>to be an official society of tasters. I don't know

0:13:24.240 --> 0:13:29.600
<v Speaker 1>what union they did.

0:13:29.720 --> 0:13:30.160
<v Speaker 3>Awesome?

0:13:30.280 --> 0:13:32.560
<v Speaker 1>Yeah, did they protect your family if you died, that'd

0:13:32.600 --> 0:13:32.920
<v Speaker 1>be great.

0:13:33.040 --> 0:13:33.920
<v Speaker 2>Oh, good question.

0:13:34.040 --> 0:13:34.880
<v Speaker 1>I don't know which.

0:13:36.400 --> 0:13:40.120
<v Speaker 2>You're going to you've signed up for that.

0:13:40.280 --> 0:13:42.680
<v Speaker 1>Well, But the thing is, like having a taster wouldn't

0:13:42.720 --> 0:13:46.679
<v Speaker 1>have done much good, probably because if you were going

0:13:46.720 --> 0:13:50.079
<v Speaker 1>to poison someone, you wouldn't choose a fast acting poison

0:13:50.120 --> 0:13:53.160
<v Speaker 1>because that would be very obvious, particularly if someone had

0:13:53.160 --> 0:13:58.959
<v Speaker 1>a taster, and you would also probably be more accumulative poison.

0:13:59.200 --> 0:14:01.480
<v Speaker 2>Well, you could do fast acting poison as long as

0:14:01.480 --> 0:14:03.040
<v Speaker 2>no one knew it was you that put it in

0:14:03.080 --> 0:14:04.240
<v Speaker 2>the food, right.

0:14:04.280 --> 0:14:06.320
<v Speaker 1>But the thing is, if your intent was to kill

0:14:06.440 --> 0:14:09.040
<v Speaker 1>your target and the person had a taster, yeah, yeah,

0:14:09.080 --> 0:14:11.240
<v Speaker 1>you're right, they had to have a delay because the

0:14:11.280 --> 0:14:12.680
<v Speaker 1>person is going to be way too hungry.

0:14:13.559 --> 0:14:16.040
<v Speaker 3>They don't. I mean, come on, if your poison subject

0:14:16.040 --> 0:14:16.880
<v Speaker 3>has a taster.

0:14:17.240 --> 0:14:19.560
<v Speaker 1>We're not telling you how to poison someone.

0:14:19.320 --> 0:14:20.440
<v Speaker 2>But we're just telling you.

0:14:20.680 --> 0:14:27.160
<v Speaker 1>But if we're talking hypothetical to here everyone. So anyway,

0:14:27.440 --> 0:14:31.200
<v Speaker 1>poisonings happened frequently, and as per usual, the law had

0:14:31.240 --> 0:14:35.160
<v Speaker 1>to catch up with the popular trends. Eventually, cultivating certain

0:14:35.200 --> 0:14:39.680
<v Speaker 1>poisonous plants became a capital offense, really a capital offense,

0:14:40.400 --> 0:14:44.800
<v Speaker 1>and entire legal institutions were responsible for dishing out punishments

0:14:45.040 --> 0:14:46.000
<v Speaker 1>for poisoners.

0:14:46.680 --> 0:14:48.600
<v Speaker 3>Wow, as a gardener, that upsets me.

0:14:50.080 --> 0:14:52.840
<v Speaker 1>Why the cultivation side of it?

0:14:52.840 --> 0:14:54.680
<v Speaker 3>I want to get arrested. Well, I guess there's still

0:14:54.680 --> 0:14:56.880
<v Speaker 3>our plants. I could get arrested, but.

0:14:57.520 --> 0:14:59.800
<v Speaker 2>In Illinois no one should come after my mom.

0:14:59.760 --> 0:15:02.960
<v Speaker 3>Said, don't tread on my monk's hood.

0:15:03.240 --> 0:15:05.040
<v Speaker 2>Don't tread on my monk's head.

0:15:06.600 --> 0:15:10.640
<v Speaker 1>Oh my god, that's funny. So yeah, these entire legal

0:15:10.680 --> 0:15:15.600
<v Speaker 1>institutions were responsible for dishing out punishments for poisoners, and

0:15:15.760 --> 0:15:19.520
<v Speaker 1>those punishments weren't far from the crime itself. At one point,

0:15:19.520 --> 0:15:22.240
<v Speaker 1>in three hundred and thirty one BC, a whole slew

0:15:22.280 --> 0:15:25.080
<v Speaker 1>of women one hundred and seventy actually.

0:15:25.280 --> 0:15:29.040
<v Speaker 3>Were the unit of one hundred and seventy women is

0:15:29.080 --> 0:15:32.640
<v Speaker 3>one slu It's kind of like sorry, I'm sorry.

0:15:32.240 --> 0:15:42.640
<v Speaker 1>Three pecks. No one and a half bushels were Anyway,

0:15:42.720 --> 0:15:47.680
<v Speaker 1>these these poor Slough were accused, tried, and convicted of

0:15:47.800 --> 0:15:51.680
<v Speaker 1>mass poisoning of men, husbands, lovers, people who stood in

0:15:51.680 --> 0:15:54.560
<v Speaker 1>their way, et cetera. And during the trial some were

0:15:54.560 --> 0:15:57.720
<v Speaker 1>told to drink their prepared potions as proof of innocence.

0:15:58.560 --> 0:16:02.720
<v Speaker 1>As I've said, there's a line between poison and medicine,

0:16:02.800 --> 0:16:06.440
<v Speaker 1>with dosage as one of the deciding factors. And all

0:16:06.480 --> 0:16:09.720
<v Speaker 1>the women died whoops, or were put to death.

0:16:10.000 --> 0:16:10.720
<v Speaker 3>Yeah.

0:16:10.920 --> 0:16:15.360
<v Speaker 1>So, though poisons continued to be used in battle, whether

0:16:15.720 --> 0:16:19.720
<v Speaker 1>through poison tipped arrows or intentionally contamining water supplies, which

0:16:19.760 --> 0:16:23.440
<v Speaker 1>did happen multiple times, they maintained their reputation as a

0:16:23.600 --> 0:16:26.440
<v Speaker 1>woman's choice for murder. And in fact, the star of

0:16:26.480 --> 0:16:32.320
<v Speaker 1>today's episode, Aconite, was referred to as stepmother's poison or

0:16:32.640 --> 0:16:36.720
<v Speaker 1>the mother in law's poison. So poison has his reputation

0:16:36.840 --> 0:16:40.640
<v Speaker 1>for being a woman's weapon, right, and some women leaned

0:16:40.640 --> 0:16:46.600
<v Speaker 1>into this, making lives for themselves as professional poisoners. She's

0:16:46.640 --> 0:16:50.720
<v Speaker 1>a witch or poison consultants.

0:16:51.080 --> 0:16:53.520
<v Speaker 2>Oh oh, yeah, it's a good business card.

0:16:53.680 --> 0:16:56.160
<v Speaker 1>I mean, it's great. So Lacusta, I don't know if

0:16:56.160 --> 0:16:59.560
<v Speaker 1>that's how you say her name. Lc Usta was a

0:16:59.600 --> 0:17:05.080
<v Speaker 1>former slave turned consultant for Nero, Roman Emperor. Nero later emperor,

0:17:05.520 --> 0:17:11.080
<v Speaker 1>who was so thirsty for the emperor physition seriously, and

0:17:11.160 --> 0:17:14.840
<v Speaker 1>so she helped him kill the current emperor, Claudius's son,

0:17:15.400 --> 0:17:20.040
<v Speaker 1>and then helped Claudius's wife to kill Claudius himself, clearing

0:17:20.040 --> 0:17:23.040
<v Speaker 1>the path for Nero. And with the fall of the

0:17:23.119 --> 0:17:27.640
<v Speaker 1>Roman Empire, the field of poisoning, toxicology, and medicinal plants,

0:17:27.680 --> 0:17:30.639
<v Speaker 1>both in research and practice, seem to retreat to the

0:17:30.640 --> 0:17:34.120
<v Speaker 1>shadows in that part of the world, but it would

0:17:34.200 --> 0:17:37.439
<v Speaker 1>continue to be built upon and much expanded by physicians

0:17:37.440 --> 0:17:42.399
<v Speaker 1>and scientists like Avicenna in the Islamic Golden Age. Okay,

0:17:42.600 --> 0:17:46.359
<v Speaker 1>all right, so early history of poisons check, we're done.

0:17:46.760 --> 0:17:49.800
<v Speaker 1>But where does aconite fit into all of this? Yeah? Well,

0:17:50.000 --> 0:17:52.159
<v Speaker 1>to answer that, we're going to dive back into some

0:17:52.280 --> 0:17:55.480
<v Speaker 1>mythology briefly. Are you ready for this?

0:17:55.800 --> 0:17:56.240
<v Speaker 2>Always?

0:17:56.560 --> 0:17:56.919
<v Speaker 4>Yes?

0:17:56.960 --> 0:18:00.439
<v Speaker 1>All right, Let's take a trip back to the summer

0:18:00.600 --> 0:18:05.639
<v Speaker 1>before tenth grade. I don't want to do this my

0:18:05.720 --> 0:18:10.199
<v Speaker 1>tenth grade. So in between doing really cool hip things

0:18:11.040 --> 0:18:15.919
<v Speaker 1>like rereading Harry Potter one through five, I worked on

0:18:15.960 --> 0:18:21.480
<v Speaker 1>my summer assignment, Edith Hamilton's Mythology. So Edith Hamilton's Mythology

0:18:21.760 --> 0:18:25.560
<v Speaker 1>and Harry Potter is where my love for Harry Potter

0:18:25.720 --> 0:18:28.320
<v Speaker 1>met my love for trivia and origin stories.

0:18:28.600 --> 0:18:33.359
<v Speaker 3>You do love those things. Every movie I've ever watched

0:18:33.400 --> 0:18:37.520
<v Speaker 3>with this Aaron usually has a segment for trivia somewhere

0:18:37.600 --> 0:18:39.000
<v Speaker 3>between halfway through, and.

0:18:41.080 --> 0:18:43.840
<v Speaker 1>That's why we love her, all right, So this is

0:18:44.640 --> 0:18:49.440
<v Speaker 1>basically when I read Edith Hamilton, I learned about Cerberus,

0:18:49.640 --> 0:18:53.119
<v Speaker 1>who was the three headed dog that guarded the entrance

0:18:53.160 --> 0:18:57.920
<v Speaker 1>to the underworld and served as inspiration for all Yeah,

0:18:57.960 --> 0:18:58.800
<v Speaker 1>you got a girl.

0:19:00.160 --> 0:19:03.679
<v Speaker 2>Fluffy was the dog that guarded the place where they

0:19:03.800 --> 0:19:06.280
<v Speaker 2>kept the Philosopher's Stone, the Sorcerer's Stone.

0:19:06.359 --> 0:19:09.120
<v Speaker 1>Yeah, at least somewhere along that pathway exactly, you got

0:19:09.119 --> 0:19:12.959
<v Speaker 1>it anyway, So I was really excited to see that

0:19:13.000 --> 0:19:20.960
<v Speaker 1>crossover there. Okay, so it turns out that Hercules. Remember

0:19:21.000 --> 0:19:22.320
<v Speaker 1>I was gonna I told you that we were going

0:19:22.400 --> 0:19:25.560
<v Speaker 1>to circle back to this in order to repent for

0:19:25.640 --> 0:19:29.040
<v Speaker 1>killing his wife and kids the first time. The first

0:19:29.119 --> 0:19:33.560
<v Speaker 1>time his first wife and his five kids. I think five? Whoa,

0:19:34.359 --> 0:19:37.760
<v Speaker 1>it was okay if you killed two. I mean five

0:19:37.880 --> 0:19:41.080
<v Speaker 1>just seems extreme, doesn't it. He was crazy by Hara

0:19:41.240 --> 0:19:44.560
<v Speaker 1>who else? Yeah, Well, in order to repent for this,

0:19:44.640 --> 0:19:48.440
<v Speaker 1>he had to perform various feats of strength, including capturing

0:19:48.560 --> 0:19:52.439
<v Speaker 1>Cerberus and bringing him to the surface. While he was

0:19:52.520 --> 0:19:56.920
<v Speaker 1>up there, Cerberus got off foamy mouthed because he wasn't

0:19:57.000 --> 0:20:01.520
<v Speaker 1>used to sunlight. Rabies sound like rabies.

0:20:01.200 --> 0:20:07.080
<v Speaker 2>Teas and water spoilers, It's going to be our first

0:20:07.119 --> 0:20:09.920
<v Speaker 2>episode of ease in two. Everybody get excited.

0:20:11.119 --> 0:20:16.840
<v Speaker 1>In any case, Cerberus's spit flew everywhere and where it landed,

0:20:17.040 --> 0:20:22.560
<v Speaker 1>Aconite grew, and from these humble beginnings, aconite gained a

0:20:22.600 --> 0:20:26.040
<v Speaker 1>reputation as one of the deadliest poisons in ancient times

0:20:26.600 --> 0:20:33.199
<v Speaker 1>seriously forking, deadly wow, Yeah Heckeate goddess of witchcraft, and

0:20:33.280 --> 0:20:38.600
<v Speaker 1>also in Shakespeare's Macbeth, one of the wishes discovered its

0:20:38.760 --> 0:20:42.480
<v Speaker 1>use as a poison, and Greek shepherds would smear aconite

0:20:42.560 --> 0:20:45.760
<v Speaker 1>juice on arrows or mix the plant with raw meat

0:20:45.880 --> 0:20:49.600
<v Speaker 1>to protect their sheep from wolves. Hence, the name wolves Spain.

0:20:50.200 --> 0:20:52.399
<v Speaker 2>Oh, so they would put it on so that the

0:20:52.440 --> 0:20:55.320
<v Speaker 2>wolves would die it with the Yeah. Interesting.

0:20:55.640 --> 0:20:57.800
<v Speaker 1>So like a lot of what I what I learned

0:20:57.840 --> 0:21:00.800
<v Speaker 1>in some of this, like reading about ancients, is that

0:21:00.840 --> 0:21:04.880
<v Speaker 1>anything with wood after it, if it was wormwood used

0:21:04.880 --> 0:21:09.400
<v Speaker 1>to treat worms, Hen's bane wolf Spain. You are trying

0:21:09.440 --> 0:21:14.120
<v Speaker 1>to kill whatever? So what ishood you trying to kill?

0:21:14.320 --> 0:21:15.280
<v Speaker 3>No? No, no, months.

0:21:17.960 --> 0:21:20.399
<v Speaker 2>Which we'll get to see. I haven't looked at any.

0:21:20.320 --> 0:21:22.240
<v Speaker 3>Pictures yet, which I'm so excited.

0:21:22.440 --> 0:21:26.960
<v Speaker 1>Yeah. Other species in the aconite genus have been used

0:21:26.960 --> 0:21:30.520
<v Speaker 1>to poison arrows in Japan, in the Himalayas, in China,

0:21:31.080 --> 0:21:35.760
<v Speaker 1>and in Alaska, so all over. Basically on one Greek island,

0:21:36.359 --> 0:21:39.680
<v Speaker 1>aconite was put in the drinks of old men when

0:21:39.680 --> 0:21:43.360
<v Speaker 1>they were quote no longer of use to the community.

0:21:44.320 --> 0:21:49.479
<v Speaker 1>Early references to aconite emphasize it's extremely potent nature. If

0:21:49.520 --> 0:21:51.879
<v Speaker 1>you were going to use aconite, you should be wearing

0:21:51.960 --> 0:21:56.359
<v Speaker 1>protective clothing while gardening and avoid breathing in any of

0:21:56.440 --> 0:21:59.040
<v Speaker 1>the aconite powder during preparation.

0:21:59.520 --> 0:21:59.960
<v Speaker 2>Wow.

0:22:00.000 --> 0:22:04.800
<v Speaker 1>Oh, preparation for poisons apparently continue to this day.

0:22:05.000 --> 0:22:07.520
<v Speaker 2>Yes, well absolutely, I can't wait to hear more about

0:22:07.560 --> 0:22:08.560
<v Speaker 2>the plant. Itself.

0:22:08.840 --> 0:22:13.840
<v Speaker 1>Oh yeah, okay, I'll get to it. Then aaronski use me.

0:22:15.280 --> 0:22:21.240
<v Speaker 1>That was just a I'm excited, okay, yeah, where the

0:22:21.240 --> 0:22:24.880
<v Speaker 1>smell of the plant alone was thought to be strong

0:22:25.040 --> 0:22:27.439
<v Speaker 1>enough to cause illness or death.

0:22:27.720 --> 0:22:28.640
<v Speaker 2>Whoa.

0:22:28.800 --> 0:22:34.200
<v Speaker 1>Somewhere along the way, though, the language around aconite changed.

0:22:34.920 --> 0:22:39.000
<v Speaker 1>It turned from poison to medicine. You name it, aconite,

0:22:39.000 --> 0:22:41.919
<v Speaker 1>will treat it, seemed to be the motto, and that

0:22:42.000 --> 0:22:45.840
<v Speaker 1>happened around the mid seventeen hundreds. It was prescribed by

0:22:45.880 --> 0:22:49.359
<v Speaker 1>many doctors when a good sweat was needed. This is

0:22:49.400 --> 0:22:53.399
<v Speaker 1>back when the ancient concept of various bodily humors still

0:22:53.440 --> 0:22:57.520
<v Speaker 1>held sway in the medical field. Oddly enough, aconite didn't

0:22:57.560 --> 0:23:01.720
<v Speaker 1>prove to be a particularly rely liable or safe treatment

0:23:02.119 --> 0:23:05.040
<v Speaker 1>and gradually fell out of favor in the medical community

0:23:05.560 --> 0:23:09.439
<v Speaker 1>after the treatment didn't agree with one too many patients.

0:23:09.040 --> 0:23:11.199
<v Speaker 3>And by agree, we mean like it killed one too

0:23:11.240 --> 0:23:12.040
<v Speaker 3>many patients.

0:23:12.119 --> 0:23:17.840
<v Speaker 1>Thank you, exactly exactly. But that didn't mark the end

0:23:18.000 --> 0:23:21.520
<v Speaker 1>for aconite. Where it initially failed to gain support in

0:23:21.560 --> 0:23:26.359
<v Speaker 1>the Orthodox medical community, it found in homeopathy. Under the

0:23:26.400 --> 0:23:32.240
<v Speaker 1>concept of like cures. Like drugs such as aconite were

0:23:32.359 --> 0:23:37.040
<v Speaker 1>used to treat diseases which had similar symptoms. Aconite was

0:23:37.160 --> 0:23:41.480
<v Speaker 1>used for acute diseases, especially those characterized by fever and pain.

0:23:42.240 --> 0:23:46.120
<v Speaker 1>It gained reputation as a substitute for blood letting. Probably

0:23:47.000 --> 0:23:51.200
<v Speaker 1>it's treating one evil for another poisoning, right, I mean

0:23:51.280 --> 0:23:56.080
<v Speaker 1>you know which. In these times, people were always looking

0:23:56.160 --> 0:24:01.040
<v Speaker 1>for an excuse to bloodlet Apparently, aconite were best on

0:24:01.200 --> 0:24:05.800
<v Speaker 1>fearful nervous patients and to calm and it was used

0:24:05.840 --> 0:24:12.920
<v Speaker 1>to calm women down during nasty periods, the ultimate all

0:24:13.000 --> 0:24:13.520
<v Speaker 1>your period.

0:24:15.080 --> 0:24:16.960
<v Speaker 2>You might, you might, you might, Maybe I need to

0:24:18.200 --> 0:24:20.800
<v Speaker 2>calm myself down during my rageful period.

0:24:21.160 --> 0:24:22.880
<v Speaker 3>She's raging, very paging.

0:24:23.760 --> 0:24:27.040
<v Speaker 1>I should mention, though, that the actual amount of aconite

0:24:27.040 --> 0:24:30.719
<v Speaker 1>in many of these remedies was so teeny tiny small

0:24:31.520 --> 0:24:36.280
<v Speaker 1>that it was negligible. Homeopaths were publishing on aconite left

0:24:36.320 --> 0:24:41.199
<v Speaker 1>and right, and around the mid eighteen hundreds, orthodox physicians

0:24:41.280 --> 0:24:45.560
<v Speaker 1>started paying attention, which is kind of interesting. Aconite in

0:24:45.680 --> 0:24:49.399
<v Speaker 1>certain carefully measured doses seem to be effective as a

0:24:49.440 --> 0:24:53.520
<v Speaker 1>neural suppressant, meaning a drug that inhibits activity of parts

0:24:53.560 --> 0:24:59.320
<v Speaker 1>of the nervous system, particularly in controlling inflammation. Don't worry,

0:24:59.359 --> 0:25:00.520
<v Speaker 1>I'm not gonna stop on your toes.

0:25:00.600 --> 0:25:01.040
<v Speaker 3>Don't worry.

0:25:01.160 --> 0:25:02.600
<v Speaker 2>I'll talk so much more about it.

0:25:02.720 --> 0:25:09.800
<v Speaker 1>Wonderful, I love it. But so when when it was

0:25:09.840 --> 0:25:13.120
<v Speaker 1>found to actually have these effects, it became all the rage.

0:25:13.560 --> 0:25:16.960
<v Speaker 1>So throughout the eighteen hundreds and into the early nineteen hundreds,

0:25:17.040 --> 0:25:22.480
<v Speaker 1>aconite or aconite mixed with other things like chloroform and belladonna.

0:25:22.640 --> 0:25:27.199
<v Speaker 1>Oh good lord, yep was used as a painkiller or

0:25:27.240 --> 0:25:30.800
<v Speaker 1>to treat infection, lung conditions, nerve pain, and so on.

0:25:31.200 --> 0:25:31.800
<v Speaker 2>Wow.

0:25:32.200 --> 0:25:36.679
<v Speaker 1>The adoption of aconite by Orthodox physicians from homeopathy was

0:25:36.800 --> 0:25:39.960
<v Speaker 1>also a big deal. But we're still talking about a

0:25:39.960 --> 0:25:44.439
<v Speaker 1>poison here. And just because something alters your physiology in

0:25:44.480 --> 0:25:47.400
<v Speaker 1>a way that does not kill or name, does not

0:25:47.560 --> 0:25:51.080
<v Speaker 1>make it good for you. Word yea. And so we

0:25:51.160 --> 0:25:53.840
<v Speaker 1>circle back to the question I pose at the beginning

0:25:53.880 --> 0:25:57.639
<v Speaker 1>of this what is the difference between a physician and

0:25:57.680 --> 0:26:03.159
<v Speaker 1>a pretender, a magician, a poisoner? Yeah, the answer lies

0:26:03.640 --> 0:26:10.400
<v Speaker 1>somewhere between ignorance and intent. So, Aaron, tell us what

0:26:10.760 --> 0:26:26.640
<v Speaker 1>exactly does aconite do that makes it a poison? All right?

0:26:26.760 --> 0:26:32.800
<v Speaker 2>Let me tell you about wolf, spain, monkshood, et cetera.

0:26:33.800 --> 0:26:41.320
<v Speaker 2>All right, So, yeah, these plants, because we know there's

0:26:41.400 --> 0:26:47.080
<v Speaker 2>multiples contain a compound called a conatine. This is the

0:26:47.200 --> 0:26:51.960
<v Speaker 2>compound that actually makes you sick. And later in just

0:26:52.040 --> 0:26:55.359
<v Speaker 2>a few minutes, because I'm gonna be quick, Matt is

0:26:55.440 --> 0:26:58.720
<v Speaker 2>going to tell you about why these plants actually contain

0:26:58.800 --> 0:27:01.320
<v Speaker 2>this compound. To begin with, like, what's the point of

0:27:01.480 --> 0:27:05.479
<v Speaker 2>having something that kills people in you as a plant tissue?

0:27:05.600 --> 0:27:07.960
<v Speaker 1>Which is a really fun question I can't wait to

0:27:08.040 --> 0:27:08.400
<v Speaker 1>hear about.

0:27:09.520 --> 0:27:12.040
<v Speaker 2>But first let me tell you so that I have

0:27:12.200 --> 0:27:16.520
<v Speaker 2>a point to being here, what actually happens to your

0:27:16.600 --> 0:27:20.200
<v Speaker 2>body when you ingest this plant? Like, what is actually

0:27:20.280 --> 0:27:20.960
<v Speaker 2>making you sick?

0:27:21.080 --> 0:27:23.000
<v Speaker 3>When you go out on a limb and say it's not.

0:27:23.160 --> 0:27:29.600
<v Speaker 2>Pleasant, it's not at all? Okay, So a conotine affects

0:27:29.720 --> 0:27:32.320
<v Speaker 2>a bunch of different parts of your body, but the

0:27:32.400 --> 0:27:35.639
<v Speaker 2>effects that are most important are what it has on

0:27:35.760 --> 0:27:39.240
<v Speaker 2>both your heart tissue and your nervous system. But the

0:27:39.320 --> 0:27:42.840
<v Speaker 2>effects are pretty widespread. So it can affect your GI tract,

0:27:43.359 --> 0:27:47.480
<v Speaker 2>your nervous system, your heart. It has a pretty widespread effect.

0:27:48.080 --> 0:27:51.320
<v Speaker 2>So what actually happens when you take a bite of

0:27:52.200 --> 0:27:55.000
<v Speaker 2>wolf spain for example, or you take a pill that

0:27:55.080 --> 0:27:58.560
<v Speaker 2>someone gave you that's like full of it, sip just

0:27:58.680 --> 0:28:03.399
<v Speaker 2>a sip of a tincture or something. Right within a

0:28:03.560 --> 0:28:07.040
<v Speaker 2>really short amount of time, like as little as ten

0:28:07.160 --> 0:28:12.120
<v Speaker 2>minutes or maximum like two hours. Whoa, right, it's really

0:28:12.240 --> 0:28:16.400
<v Speaker 2>fast acting. You'll start to see symptoms that include numbness

0:28:16.800 --> 0:28:21.440
<v Speaker 2>in your face or limbs, periestiesia, which is a fancy

0:28:21.480 --> 0:28:24.520
<v Speaker 2>word for you feel a tingling or a burning sensation.

0:28:25.160 --> 0:28:31.840
<v Speaker 2>Could be until it's not. You might have some muscle weakness.

0:28:32.359 --> 0:28:37.040
<v Speaker 2>You'll become hypotensive, which means your blood pressure drops really low.

0:28:37.520 --> 0:28:39.040
<v Speaker 1>That's not good. It's never good.

0:28:40.200 --> 0:28:43.840
<v Speaker 2>And then your heart, and this is important, it might

0:28:43.960 --> 0:28:49.240
<v Speaker 2>begin to race really fast, or it might slow way

0:28:49.400 --> 0:28:50.240
<v Speaker 2>way way down.

0:28:50.520 --> 0:28:51.120
<v Speaker 3>I don't like that.

0:28:51.600 --> 0:28:52.840
<v Speaker 2>It could go either way.

0:28:53.360 --> 0:28:54.440
<v Speaker 1>It could go either way.

0:28:54.560 --> 0:28:58.840
<v Speaker 3>It could go that's the scariest or not. You've poisoned.

0:29:00.160 --> 0:29:01.440
<v Speaker 1>Talk a lot about it.

0:29:01.520 --> 0:29:05.240
<v Speaker 2>You don't worry. Flip a coin, Flip a coin. No,

0:29:06.360 --> 0:29:08.080
<v Speaker 2>we'll talk about why don't worry.

0:29:08.200 --> 0:29:09.960
<v Speaker 1>This is why I don't wild forage.

0:29:10.480 --> 0:29:14.160
<v Speaker 2>That's a good reason not to. And then on top

0:29:14.240 --> 0:29:19.040
<v Speaker 2>of that, you might also have things like nausea, vomiting, diarrhea.

0:29:19.640 --> 0:29:23.160
<v Speaker 3>Of course, you sound like I was gonna say, na.

0:29:27.200 --> 0:29:27.920
<v Speaker 1>Diarrhea.

0:29:28.320 --> 0:29:33.280
<v Speaker 2>Yep, all of that, all of that if you manage

0:29:33.360 --> 0:29:38.640
<v Speaker 2>to get to a hospital and you don't die, if

0:29:38.680 --> 0:29:42.200
<v Speaker 2>it's possible and you get to a hospital, the good

0:29:42.280 --> 0:29:45.600
<v Speaker 2>news is that within twenty four hours you'll probably be

0:29:45.720 --> 0:29:48.840
<v Speaker 2>fine because this is very fast acting. But it's also

0:29:49.120 --> 0:29:51.520
<v Speaker 2>it's a pretty quick recovery, so it has a very

0:29:51.680 --> 0:29:55.480
<v Speaker 2>short half life in your body, right. Your body digests

0:29:55.520 --> 0:29:59.800
<v Speaker 2>it very quickly. But and I didn't look up enough

0:29:59.840 --> 0:30:02.880
<v Speaker 2>to detail probably about the actual mortality rate, but at

0:30:02.960 --> 0:30:06.920
<v Speaker 2>least in this article that I found, even in hospital cases,

0:30:06.960 --> 0:30:10.120
<v Speaker 2>the mortality rate is over five percent. So even if

0:30:10.160 --> 0:30:12.160
<v Speaker 2>you manage to get to the hospital and get treatment,

0:30:12.280 --> 0:30:14.760
<v Speaker 2>you still have an over five percent chance of dying.

0:30:14.920 --> 0:30:18.239
<v Speaker 1>Well, so that's that's really interesting because that mortality rate

0:30:18.280 --> 0:30:21.200
<v Speaker 1>would have to do with modern cases. So, yeah, intentional

0:30:21.320 --> 0:30:23.920
<v Speaker 1>poisoning or I ate way too much of this really

0:30:23.960 --> 0:30:24.520
<v Speaker 1>weird thing.

0:30:25.120 --> 0:30:29.080
<v Speaker 2>Well, but also which happens, it's also a very common

0:30:29.160 --> 0:30:32.000
<v Speaker 2>thing that's used in a lot of herbal remedies.

0:30:32.040 --> 0:30:33.920
<v Speaker 1>Okay, good, I was going to ask you about the

0:30:34.040 --> 0:30:36.160
<v Speaker 1>current status of acne idea.

0:30:36.280 --> 0:30:39.040
<v Speaker 2>Yeah, yeah, so it is definitely a thing, and there's

0:30:39.080 --> 0:30:41.720
<v Speaker 2>a lot of information out there about what people tend

0:30:41.800 --> 0:30:45.440
<v Speaker 2>to do to treat this either the leaves or the

0:30:45.560 --> 0:30:48.600
<v Speaker 2>roots that they're using in order to make it less

0:30:48.720 --> 0:30:53.280
<v Speaker 2>toxic but still have less Yes, exactly, I think you'll

0:30:53.360 --> 0:30:54.160
<v Speaker 2>you'll probably talk more.

0:30:54.480 --> 0:30:56.720
<v Speaker 3>Yeah, and and and the fact that this is a crossover,

0:30:56.800 --> 0:30:58.920
<v Speaker 3>this is a subject will be covering probably a little

0:30:58.920 --> 0:30:59.320
<v Speaker 3>bit more.

0:30:59.560 --> 0:31:01.080
<v Speaker 1>Next week, exactly.

0:31:01.720 --> 0:31:05.480
<v Speaker 2>But yeah, so it's it is still very commonly used

0:31:05.520 --> 0:31:09.240
<v Speaker 2>in a lot of sort of traditional medicine type things. Okay,

0:31:09.280 --> 0:31:14.120
<v Speaker 2>So here's the question, though, How on earth can just

0:31:14.320 --> 0:31:19.160
<v Speaker 2>eating a plant cause so many different symptoms, everything from

0:31:19.360 --> 0:31:24.160
<v Speaker 2>numbness or muscle weakness to the general cause of death

0:31:24.280 --> 0:31:28.040
<v Speaker 2>is actually heart failure. Your heart just fully stops, it

0:31:28.200 --> 0:31:30.040
<v Speaker 2>can't handle it, it gives out.

0:31:30.280 --> 0:31:31.160
<v Speaker 1>That's terrifying.

0:31:31.360 --> 0:31:36.080
<v Speaker 2>So how can a plant actually cause something that a

0:31:36.160 --> 0:31:41.440
<v Speaker 2>lot of these symptoms, nausea, muscle weakness, these seem very disparate, right,

0:31:41.640 --> 0:31:46.760
<v Speaker 2>So the question is systems, right, what on earth is happening?

0:31:48.000 --> 0:31:50.560
<v Speaker 1>Let me tell you I didn't.

0:31:52.280 --> 0:31:57.480
<v Speaker 2>I'm just like, go ahead and google it. Here's what happens.

0:31:58.720 --> 0:32:03.400
<v Speaker 2>The major compound that's in these plants, a conatine, attacks

0:32:03.960 --> 0:32:09.280
<v Speaker 2>your sodium channels. Here's what you need to know to

0:32:09.480 --> 0:32:14.400
<v Speaker 2>understand how this compound, a conatine actually affects your system.

0:32:15.080 --> 0:32:19.360
<v Speaker 2>Number one. You all know hopefully that your nervous system

0:32:19.600 --> 0:32:22.720
<v Speaker 2>is generally in charge of your body, right. It sends

0:32:22.840 --> 0:32:25.760
<v Speaker 2>signals to different parts of your body that say things

0:32:25.920 --> 0:32:30.320
<v Speaker 2>like contract this muscle or release this hormone.

0:32:29.920 --> 0:32:32.720
<v Speaker 3>Et cetera, go to the bathroom now exactly.

0:32:34.640 --> 0:32:37.760
<v Speaker 2>So the way that it sends these signals is by

0:32:38.120 --> 0:32:46.600
<v Speaker 2>moving ions, which just means a charge molecule across membranes. Okay, Sodium,

0:32:47.080 --> 0:32:50.680
<v Speaker 2>which is a positive ion, is one of the most

0:32:50.760 --> 0:32:55.800
<v Speaker 2>important things involved in sending these signals. So sodium tends

0:32:55.840 --> 0:32:59.240
<v Speaker 2>to be really high in concentration outside of cells and

0:32:59.520 --> 0:33:04.160
<v Speaker 2>lower inside of cells with me, so far, sure, great.

0:33:05.000 --> 0:33:09.520
<v Speaker 2>So the other ion that's important is potassium. Potassium is

0:33:09.600 --> 0:33:12.200
<v Speaker 2>higher inside of cells and lower.

0:33:12.200 --> 0:33:14.000
<v Speaker 1>Outside of the opposite of sodium.

0:33:14.240 --> 0:33:20.280
<v Speaker 2>Exactly, sodium outside, potassium inside, and overall, the insides of

0:33:20.360 --> 0:33:25.200
<v Speaker 2>your cells are negatively charged compared to the outside.

0:33:24.800 --> 0:33:25.360
<v Speaker 1>Of your cells.

0:33:25.480 --> 0:33:26.080
<v Speaker 2>Did not know that.

0:33:26.320 --> 0:33:26.760
<v Speaker 3>There we go.

0:33:27.000 --> 0:33:34.440
<v Speaker 2>We're learning new things, all right. So ions, these charged

0:33:34.560 --> 0:33:40.000
<v Speaker 2>molecules cannot cross your cellular membranes because they're charged, and

0:33:40.120 --> 0:33:43.560
<v Speaker 2>your cell membranes are basically fat globules.

0:33:44.240 --> 0:33:46.240
<v Speaker 3>Okay, more than my cell membranes.

0:33:49.440 --> 0:33:54.200
<v Speaker 2>So these charged molecules can't cross the fat. They don't

0:33:54.280 --> 0:33:56.800
<v Speaker 2>like each other. Okay, So the way that they cross

0:33:57.360 --> 0:34:00.920
<v Speaker 2>is by channels, which are like doors that open and

0:34:01.120 --> 0:34:04.760
<v Speaker 2>close and allow these ions to cross this membrane with

0:34:05.000 --> 0:34:08.839
<v Speaker 2>me mm hm totally excellent. So the way that your

0:34:08.960 --> 0:34:13.399
<v Speaker 2>nervous system actually sends these signals to tell everything else

0:34:13.440 --> 0:34:16.000
<v Speaker 2>in your body what to do is by propagating what

0:34:16.120 --> 0:34:21.560
<v Speaker 2>we call action potentials, which basically just means that they

0:34:21.920 --> 0:34:25.560
<v Speaker 2>open a channel and it's a channel that is specific

0:34:25.680 --> 0:34:29.840
<v Speaker 2>to sodium, which we know is at high concentrations outside

0:34:29.840 --> 0:34:32.600
<v Speaker 2>of your cell, and then a bunch of sodium rushes

0:34:32.880 --> 0:34:36.120
<v Speaker 2>into the cell. And then they close that channel and

0:34:36.160 --> 0:34:38.040
<v Speaker 2>they're like, okay, now we've got a bunch of sodium

0:34:38.320 --> 0:34:41.880
<v Speaker 2>inside of the cell. And then they open another channel

0:34:42.120 --> 0:34:45.880
<v Speaker 2>and they're like potassium, it's your turn, and potassium rushes

0:34:45.960 --> 0:34:46.839
<v Speaker 2>out of the cell.

0:34:47.320 --> 0:34:48.120
<v Speaker 1>Okay, okay.

0:34:48.400 --> 0:34:52.040
<v Speaker 2>So that is how they propagate these signals, is they go.

0:34:52.320 --> 0:34:54.320
<v Speaker 1>That's how it transfers down exactly.

0:34:54.560 --> 0:34:57.960
<v Speaker 2>So that's you, for example, you touch something that's hot,

0:34:58.120 --> 0:35:00.840
<v Speaker 2>right and your skin feel that and it's like this

0:35:01.000 --> 0:35:03.600
<v Speaker 2>thing is hot. So then that sends a signal that

0:35:03.680 --> 0:35:07.520
<v Speaker 2>says sodium go, and then your sodium channels open, sodium

0:35:07.600 --> 0:35:13.000
<v Speaker 2>rushes into your cells. Those doors close, and then the

0:35:13.280 --> 0:35:16.839
<v Speaker 2>open ones that say potassium, it's your turn, potassium rushes out,

0:35:17.160 --> 0:35:20.640
<v Speaker 2>et cetera. You can google some really great YouTube videos

0:35:20.760 --> 0:35:21.560
<v Speaker 2>of this, but.

0:35:21.680 --> 0:35:24.000
<v Speaker 3>Essentially what you're saying is this is holding to the

0:35:24.080 --> 0:35:26.879
<v Speaker 3>whole universal constant of things move from high to low

0:35:26.960 --> 0:35:31.239
<v Speaker 3>concentrations precisely mad and so I did something another.

0:35:32.680 --> 0:35:35.440
<v Speaker 1>And so this means that if you touch that hot stove,

0:35:36.160 --> 0:35:39.280
<v Speaker 1>that action potential or that that whole sequence of events

0:35:39.400 --> 0:35:42.919
<v Speaker 1>is telling you right or is allowing you to move

0:35:43.120 --> 0:35:44.480
<v Speaker 1>or telling you to move right.

0:35:44.600 --> 0:35:48.359
<v Speaker 2>So it tells your nervous system something bad is happening here.

0:35:49.000 --> 0:35:51.680
<v Speaker 2>That action potential travels all the way down your nerve

0:35:51.760 --> 0:35:54.719
<v Speaker 2>to your brain, which goes something's bad is happening. It

0:35:54.800 --> 0:35:57.080
<v Speaker 2>travels all the way back to your muscles, which go

0:35:57.560 --> 0:35:58.640
<v Speaker 2>move and then you move.

0:35:58.800 --> 0:36:02.520
<v Speaker 1>So it's like a two two parallel domino system going

0:36:02.560 --> 0:36:03.759
<v Speaker 1>in a direction.

0:36:03.680 --> 0:36:05.720
<v Speaker 2>Right, and it happens instantaneously.

0:36:06.080 --> 0:36:06.200
<v Speaker 3>Right.

0:36:06.480 --> 0:36:09.520
<v Speaker 2>So these sodium channels have to be able to open

0:36:09.719 --> 0:36:14.279
<v Speaker 2>and close extremely rapidly for these signals to be able

0:36:14.320 --> 0:36:19.280
<v Speaker 2>to propagate. So that you can do literally anything, right. Okay,

0:36:19.480 --> 0:36:23.440
<v Speaker 2>So sodium channels are really really important in you literally

0:36:23.520 --> 0:36:28.120
<v Speaker 2>being able to survive, right, So what's the point of

0:36:28.239 --> 0:36:29.960
<v Speaker 2>me telling you all this? Why did I just give

0:36:30.000 --> 0:36:32.160
<v Speaker 2>you like an intro to physiology?

0:36:32.360 --> 0:36:33.440
<v Speaker 3>I have my suspicions.

0:36:35.000 --> 0:36:38.960
<v Speaker 2>As it turns out, a conatine, the compound that's in

0:36:39.960 --> 0:36:45.520
<v Speaker 2>Monk's hood wolf span et cetera, binds to sodium channels

0:36:45.640 --> 0:36:48.600
<v Speaker 2>and it forces them to stay open.

0:36:49.080 --> 0:36:51.000
<v Speaker 1>No, oh, that's not good.

0:36:51.160 --> 0:36:54.440
<v Speaker 2>It's not good. So what happens is you end up

0:36:54.520 --> 0:36:58.080
<v Speaker 2>with a huge influx of sodium that comes into the cell,

0:36:58.719 --> 0:37:01.360
<v Speaker 2>but then you can't close that channel in order to

0:37:01.880 --> 0:37:05.880
<v Speaker 2>continue to propagate the signal. Right, So that means that

0:37:06.000 --> 0:37:08.759
<v Speaker 2>anytime you get a future signal, you can't react to

0:37:08.920 --> 0:37:13.759
<v Speaker 2>it because your sodium channels are already open. Oh I

0:37:13.920 --> 0:37:15.480
<v Speaker 2>love that was such a good reaction.

0:37:16.400 --> 0:37:17.560
<v Speaker 1>Understanding is dawning.

0:37:19.719 --> 0:37:22.520
<v Speaker 2>Okay, So what does this mean in real life? So

0:37:22.800 --> 0:37:25.440
<v Speaker 2>you take a big bite of wolf spain and you're

0:37:25.520 --> 0:37:29.279
<v Speaker 2>chewing on it, and now your sodium channels are It's

0:37:29.320 --> 0:37:34.520
<v Speaker 2>a nightmare. What's happening in your nervous system. You're not

0:37:34.760 --> 0:37:38.120
<v Speaker 2>getting any new signals being passed. You have this one

0:37:38.280 --> 0:37:42.239
<v Speaker 2>giant influx of sodium, and then that's it. You can't

0:37:42.280 --> 0:37:45.200
<v Speaker 2>make any new signals because your sodium channels are stuck

0:37:45.320 --> 0:37:49.640
<v Speaker 2>in the open position. They can't basically reset themselves, which

0:37:49.719 --> 0:37:52.600
<v Speaker 2>they have to do to be able to detect a

0:37:52.680 --> 0:37:53.240
<v Speaker 2>new signal.

0:37:53.360 --> 0:37:54.640
<v Speaker 3>So it's like you're trying to get a call, but

0:37:54.680 --> 0:37:57.319
<v Speaker 3>every time you pick up the phone so much just screaming. Yeah.

0:37:58.320 --> 0:38:00.239
<v Speaker 2>But like back in the old days when they was

0:38:00.280 --> 0:38:02.319
<v Speaker 2>like a busy signal because someone left your phone off the.

0:38:04.280 --> 0:38:05.799
<v Speaker 1>Old the old days, Like.

0:38:09.520 --> 0:38:13.439
<v Speaker 2>That's a great it's just like that, yep. So that's

0:38:13.480 --> 0:38:16.400
<v Speaker 2>why you end up with things like numbness or tingling

0:38:16.840 --> 0:38:20.000
<v Speaker 2>because your nerves are not propagating signals the way that

0:38:20.040 --> 0:38:24.960
<v Speaker 2>they're supposed to exactly well, not not really hyper firing.

0:38:25.000 --> 0:38:27.840
<v Speaker 2>They're not able to pick up any new signals.

0:38:27.960 --> 0:38:30.840
<v Speaker 1>So the way, But then the.

0:38:31.000 --> 0:38:35.680
<v Speaker 2>Question is why is this affecting your heart? Right, because

0:38:35.760 --> 0:38:38.360
<v Speaker 2>like that's weird, Except it's not that weird because it

0:38:38.440 --> 0:38:43.600
<v Speaker 2>turns out your heart doesn't actually need any nervous input

0:38:43.840 --> 0:38:46.560
<v Speaker 2>in order to beat. So you can take a heart

0:38:46.680 --> 0:38:48.960
<v Speaker 2>out of a human body and it will still beat.

0:38:49.280 --> 0:38:55.960
<v Speaker 2>It's fantastic. And that's because your heart actually generates its

0:38:56.120 --> 0:38:59.960
<v Speaker 2>own action potentials, right, It's very cool. And the way

0:39:00.160 --> 0:39:03.320
<v Speaker 2>that it does that is a very similar mechanism to

0:39:03.400 --> 0:39:07.000
<v Speaker 2>your nervous system. It's the same sodium channels, et cetera.

0:39:07.560 --> 0:39:11.800
<v Speaker 2>So that means exactly if you're opening the sodium channels

0:39:11.840 --> 0:39:14.279
<v Speaker 2>in your nervous system, you're also opening them in your

0:39:14.360 --> 0:39:19.160
<v Speaker 2>heart cells. And so your heart cells normally all communicate

0:39:19.239 --> 0:39:22.640
<v Speaker 2>with each other almost simultaneously, and that's why your heart

0:39:22.840 --> 0:39:26.080
<v Speaker 2>beats as if it's one thing.

0:39:26.560 --> 0:39:27.400
<v Speaker 3>Right. I never knew that.

0:39:27.680 --> 0:39:29.799
<v Speaker 2>Yeah, it's a bunch of little cells, right, but they

0:39:29.880 --> 0:39:32.560
<v Speaker 2>communicate with each other so seamlessly that your heart can

0:39:32.640 --> 0:39:35.680
<v Speaker 2>beat as if it's one thing, even though it's these

0:39:35.840 --> 0:39:39.359
<v Speaker 2>billions of little cells. So when you open a whole

0:39:39.360 --> 0:39:43.239
<v Speaker 2>bunch of sodium channels, that screws everything up. So you

0:39:43.360 --> 0:39:46.600
<v Speaker 2>can end up with what we call fibrillations, which means

0:39:46.640 --> 0:39:49.480
<v Speaker 2>your heart is no longer beating in sync with each other.

0:39:49.920 --> 0:39:53.759
<v Speaker 2>Different fibers are firing at different times. It's not good.

0:39:55.120 --> 0:39:58.080
<v Speaker 2>You also can end up with your heart not being

0:39:58.239 --> 0:40:02.160
<v Speaker 2>able to beat as effect because these sodium channels are open,

0:40:02.680 --> 0:40:05.799
<v Speaker 2>so it can't Again, just like your nervous system get

0:40:05.880 --> 0:40:09.080
<v Speaker 2>a new signal to tell it to beat right, so

0:40:09.320 --> 0:40:14.120
<v Speaker 2>that would slow your heart rate down. Oh, exactly right.

0:40:15.000 --> 0:40:18.880
<v Speaker 2>On the other hand, though, your heart doesn't need nervous

0:40:19.040 --> 0:40:23.200
<v Speaker 2>input in order to beat. The nervous system. Your central

0:40:23.239 --> 0:40:27.480
<v Speaker 2>nervous system, like your brain, controls via what's called your

0:40:27.520 --> 0:40:31.600
<v Speaker 2>fagus nerve, how fast your heart beats, so it can

0:40:31.680 --> 0:40:33.960
<v Speaker 2>tell your heart if you're scared or something, it'll say

0:40:34.040 --> 0:40:36.640
<v Speaker 2>beat a little quicker if this is scary, or if

0:40:36.640 --> 0:40:39.680
<v Speaker 2>everything is okay, it'll say just relax man, beat a

0:40:39.719 --> 0:40:43.600
<v Speaker 2>little slower. So that nervous system is impaired, and it

0:40:43.719 --> 0:40:48.839
<v Speaker 2>actually blocks your parasympathetic nervous system, which is your rest

0:40:49.040 --> 0:40:53.080
<v Speaker 2>and digest nervous system, so it blocks the signals that

0:40:53.120 --> 0:40:58.000
<v Speaker 2>are telling your heart. A conatine specifically, is blocking the

0:40:58.080 --> 0:41:00.560
<v Speaker 2>part of your nervous system that tells your heart chill out,

0:41:00.680 --> 0:41:03.200
<v Speaker 2>everything is fine, which makes your heart beat faster.

0:41:04.760 --> 0:41:07.840
<v Speaker 3>So it's which everyone wins out in that battle. Wow.

0:41:08.120 --> 0:41:11.080
<v Speaker 2>Right, So that's why you can have all these various

0:41:11.160 --> 0:41:14.320
<v Speaker 2>cardiac symptoms. You can have fibrillations your heart's not beating

0:41:14.360 --> 0:41:17.200
<v Speaker 2>in sync. You can have Brady cardia your heart's beating

0:41:17.239 --> 0:41:20.160
<v Speaker 2>too slowly. You can have taca cardia. Your heart's beating

0:41:20.200 --> 0:41:23.400
<v Speaker 2>too quickly, and literally all of this is because of

0:41:23.480 --> 0:41:25.720
<v Speaker 2>its effect on sodium channels.

0:41:25.800 --> 0:41:28.120
<v Speaker 1>That's really interesting, I know. So the I'm like, how

0:41:28.600 --> 0:41:31.440
<v Speaker 1>if someone might be jumping the gun, but like, if

0:41:31.480 --> 0:41:33.960
<v Speaker 1>someone had aconite poisoning.

0:41:33.520 --> 0:41:37.080
<v Speaker 2>Mm hmm, how would you know great that it was aconite?

0:41:37.120 --> 0:41:40.839
<v Speaker 2>And it's a really great question. And so I will

0:41:40.920 --> 0:41:43.719
<v Speaker 2>say that from what I've read, I have no like

0:41:44.120 --> 0:41:47.080
<v Speaker 2>because I'm gonna be a future physician, right, Like, I

0:41:47.280 --> 0:41:51.000
<v Speaker 2>have no idea how you would diagnose this. I I

0:41:51.480 --> 0:41:54.600
<v Speaker 2>I want to ask some does anyone know who works

0:41:54.640 --> 0:41:58.359
<v Speaker 2>in like an er It sounds like, okay, they've told

0:41:58.480 --> 0:42:01.000
<v Speaker 2>us so far that one of the most important things

0:42:01.000 --> 0:42:03.120
<v Speaker 2>that you can do as a physician is get a

0:42:03.280 --> 0:42:06.480
<v Speaker 2>really good history. And I think that this is the

0:42:06.560 --> 0:42:08.279
<v Speaker 2>type of thing that you would really be able to

0:42:08.360 --> 0:42:11.919
<v Speaker 2>diagnose based on history if someone said they ate something weird,

0:42:12.320 --> 0:42:16.680
<v Speaker 2>or they took these pills, or they're a forager exactly.

0:42:16.880 --> 0:42:18.919
<v Speaker 2>So this is the type of thing that it's really

0:42:18.960 --> 0:42:21.640
<v Speaker 2>important to talk to your patient or talk to a

0:42:21.719 --> 0:42:24.320
<v Speaker 2>person and get that history from them, because yeah, the

0:42:24.400 --> 0:42:27.719
<v Speaker 2>symptoms are kind of all over the place, and they

0:42:27.800 --> 0:42:31.279
<v Speaker 2>can be so varied, but at the end, what you

0:42:31.440 --> 0:42:33.799
<v Speaker 2>die from is your heart just basically giving out.

0:42:34.000 --> 0:42:36.040
<v Speaker 1>That's a really sad I know.

0:42:36.360 --> 0:42:38.440
<v Speaker 3>And this is why when people say plants are boring,

0:42:38.600 --> 0:42:42.479
<v Speaker 3>I just want to slap Yeah.

0:42:43.360 --> 0:42:45.640
<v Speaker 1>So yeah, that's that's terrify.

0:42:46.120 --> 0:42:47.200
<v Speaker 3>That is terrifying.

0:42:58.520 --> 0:43:02.680
<v Speaker 2>So then the question is why on earth do these

0:43:02.800 --> 0:43:06.560
<v Speaker 2>plants make this compound to begin with? Like, what's the point?

0:43:06.600 --> 0:43:09.359
<v Speaker 2>Are they just trying to kill people? Do plants hate people? Yeah?

0:43:09.400 --> 0:43:12.680
<v Speaker 3>They do, that's all it is. Actually, they despite being

0:43:12.760 --> 0:43:15.239
<v Speaker 3>around for many millions of years before we even came

0:43:15.280 --> 0:43:17.400
<v Speaker 3>onto the scene, they had it out for us. They

0:43:17.440 --> 0:43:18.040
<v Speaker 3>knew it was coming.

0:43:18.320 --> 0:43:19.799
<v Speaker 1>Listen, Matt, it's all about us.

0:43:20.000 --> 0:43:22.320
<v Speaker 2>Emolition has a point and is predicted.

0:43:22.360 --> 0:43:26.719
<v Speaker 3>It's hierarchical, it's directed. No, and that's a really good question,

0:43:26.840 --> 0:43:28.880
<v Speaker 3>and I'm really happy to be here to talk about

0:43:28.960 --> 0:43:31.279
<v Speaker 3>that because it's something I hold near and dear to

0:43:31.360 --> 0:43:34.240
<v Speaker 3>my heart. But I think with all this talk about

0:43:34.360 --> 0:43:37.040
<v Speaker 3>the plants, it would be worth kind of mentioning what

0:43:37.239 --> 0:43:39.000
<v Speaker 3>these plants are and what they look like. And to

0:43:39.360 --> 0:43:42.600
<v Speaker 3>do that, I think you might have noticed this ginormous,

0:43:42.800 --> 0:43:48.799
<v Speaker 3>unnecessarily large book I brought This is called The Illustrated

0:43:48.840 --> 0:43:52.640
<v Speaker 3>Treasury of Cultivated Flowers by Anderson Beautiful Illustrations, and there's

0:43:52.640 --> 0:43:55.680
<v Speaker 3>a whole section on monkshood or the econon of genus.

0:43:56.160 --> 0:43:59.799
<v Speaker 3>And it's because they are extremely popular till this day

0:44:00.080 --> 0:44:02.839
<v Speaker 3>horticultural specimens. I mean I can count four or five

0:44:02.880 --> 0:44:05.600
<v Speaker 3>houses within a few blocks of where I live that

0:44:05.800 --> 0:44:10.760
<v Speaker 3>have them prolifically seeding into their gardens. It's still extremely popular.

0:44:10.840 --> 0:44:13.080
<v Speaker 3>So I figured I would bring this book to show

0:44:13.160 --> 0:44:14.880
<v Speaker 3>both of you because one of you at least had

0:44:14.920 --> 0:44:16.920
<v Speaker 3>mentioned you hadn't googled what the plant looked like.

0:44:17.080 --> 0:44:19.120
<v Speaker 1>California Air and California.

0:44:20.440 --> 0:44:23.879
<v Speaker 3>But essentially these are perennial plants, so they come back

0:44:23.920 --> 0:44:26.879
<v Speaker 3>year after year from mountainous regions around the globe. There's

0:44:26.880 --> 0:44:29.920
<v Speaker 3>about two hundred and fifty different species of them, and

0:44:30.000 --> 0:44:33.399
<v Speaker 3>they all have these beautiful what they call palmately compound leaves.

0:44:33.480 --> 0:44:35.120
<v Speaker 3>So essentially what that means is the stem of the

0:44:35.239 --> 0:44:38.480
<v Speaker 3>leaf comes up like your wrist and attaches to your hand.

0:44:38.520 --> 0:44:41.239
<v Speaker 3>And if you picture the dissection on these leaves, they're

0:44:41.320 --> 0:44:45.360
<v Speaker 3>like a hand with just over twenty fingers. It's just

0:44:45.440 --> 0:44:49.080
<v Speaker 3>a very dissected thing with a single attachment point. Your

0:44:49.120 --> 0:44:53.120
<v Speaker 3>palm would be ly palmately compound. But the real showstopper

0:44:53.160 --> 0:44:55.239
<v Speaker 3>about these plants are their flowers. Right, So you get

0:44:55.280 --> 0:44:57.960
<v Speaker 3>these tall spikes, and I mean tall. These plants can

0:44:58.000 --> 0:45:00.600
<v Speaker 3>come up to about my chin and I'm I'm not

0:45:00.680 --> 0:45:02.319
<v Speaker 3>a tall person by any means, but you know, four

0:45:02.400 --> 0:45:04.120
<v Speaker 3>or five feet tall is pretty big for an earth

0:45:04.600 --> 0:45:07.160
<v Speaker 3>and some can get taller. But their real selling point

0:45:07.239 --> 0:45:09.560
<v Speaker 3>is their flowers, and these are gorgeous plants. They are

0:45:09.600 --> 0:45:12.640
<v Speaker 3>popular for a reason, and their flower color ranges from

0:45:12.760 --> 0:45:16.239
<v Speaker 3>yellows to deep purples. But essentially the name monkshood comes

0:45:16.280 --> 0:45:19.440
<v Speaker 3>from the fact that their petals are highly derived for

0:45:19.600 --> 0:45:23.120
<v Speaker 3>bee pollination, so kind of setting up the stage for

0:45:23.400 --> 0:45:25.760
<v Speaker 3>the shape of a bee to come and visit their flowers,

0:45:26.239 --> 0:45:28.120
<v Speaker 3>and two of the petals come up to the top

0:45:28.200 --> 0:45:30.360
<v Speaker 3>and form a hood over the reproductive parts. So it

0:45:30.480 --> 0:45:33.719
<v Speaker 3>kind of looks like a beautiful blue night wearing a

0:45:33.800 --> 0:45:36.880
<v Speaker 3>hoodie a blue They're gorgeous plants, right, I mean, this

0:45:37.000 --> 0:45:40.320
<v Speaker 3>is a beautiful picture. This is of a Conodum neapelus.

0:45:40.440 --> 0:45:42.919
<v Speaker 3>But there's plenty of others. Like I said, there's about

0:45:42.960 --> 0:45:46.080
<v Speaker 3>two hundred and fifty different species in these plants. Now,

0:45:46.600 --> 0:45:50.040
<v Speaker 3>it's worth mentioning that they are members of the buttercup family,

0:45:50.600 --> 0:45:53.680
<v Speaker 3>and most of that family, which is Ronunki lacy, have

0:45:53.840 --> 0:45:56.440
<v Speaker 3>a lot of alkaloids. They're known for their alkaloid production,

0:45:56.640 --> 0:45:59.680
<v Speaker 3>and they're toxic. They're very toxic, and for good reason.

0:45:59.760 --> 0:46:02.320
<v Speaker 3>We'll get to that. But the wolf Spain we've probably

0:46:02.440 --> 0:46:08.040
<v Speaker 3>been most referring to is acnonym lacoctinum, and that one's

0:46:08.200 --> 0:46:11.239
<v Speaker 3>native to most of Europe and northern Asia. So that's

0:46:11.280 --> 0:46:14.400
<v Speaker 3>the one that most of what you know, White European

0:46:14.600 --> 0:46:17.160
<v Speaker 3>history would have probably been writing about. But that's not

0:46:17.320 --> 0:46:19.000
<v Speaker 3>to say that there aren't others. Like I said, this

0:46:19.120 --> 0:46:21.000
<v Speaker 3>is a genus of two hundred and fifty give or

0:46:21.040 --> 0:46:25.799
<v Speaker 3>take species, all of them extremely toxic to humans. There's

0:46:25.880 --> 0:46:30.800
<v Speaker 3>also within the guys of herbalism wolf Spain, there is

0:46:31.000 --> 0:46:39.160
<v Speaker 3>econonym Cosmanthemum or sorry, casmanthem There's econonym heterophyllum and econonym violaceum.

0:46:39.520 --> 0:46:44.040
<v Speaker 3>And these are all largely Himalayan in their distribution, so India, Pakistan, Nepal,

0:46:44.920 --> 0:46:47.320
<v Speaker 3>and I think a little bit into Iraq, but I

0:46:47.640 --> 0:46:51.799
<v Speaker 3>could be mistaken about that. And they have been very

0:46:51.880 --> 0:46:55.160
<v Speaker 3>important in all of those cultures. So you talked a

0:46:55.200 --> 0:46:57.840
<v Speaker 3>lot about the history, but essentially all of the history

0:46:57.880 --> 0:47:01.560
<v Speaker 3>you gave has been used in various cures throughout history.

0:47:01.760 --> 0:47:04.160
<v Speaker 3>So more than one group of humans stumbled on to

0:47:04.239 --> 0:47:06.320
<v Speaker 3>the fact that you eat these and you're going to

0:47:06.360 --> 0:47:07.680
<v Speaker 3>be in tough shape.

0:47:07.840 --> 0:47:09.840
<v Speaker 2>You can kill your enemies.

0:47:10.200 --> 0:47:11.600
<v Speaker 1>Yeah, and you.

0:47:11.680 --> 0:47:14.880
<v Speaker 3>Mentioned econodine, right, and that's really the one that a

0:47:14.920 --> 0:47:16.719
<v Speaker 3>lot of people focus on with wolf Spain. But it's

0:47:16.760 --> 0:47:20.120
<v Speaker 3>worth mentioning that they produce lots of alkaloids. Yeah.

0:47:20.120 --> 0:47:22.359
<v Speaker 2>I didn't even talk about all the they all act

0:47:22.480 --> 0:47:25.279
<v Speaker 2>in similar ways, but yeah, I didn't even mention all

0:47:25.320 --> 0:47:26.479
<v Speaker 2>the other name.

0:47:27.160 --> 0:47:29.440
<v Speaker 3>Yeah, and alcoholtes come in many forms, but in the

0:47:29.480 --> 0:47:31.719
<v Speaker 3>context that we're talking about tonight, they're what we call

0:47:31.920 --> 0:47:35.440
<v Speaker 3>secondary metabolites and plants, and what that means is that

0:47:35.520 --> 0:47:38.239
<v Speaker 3>these are compounds that plants produce that aren't involved in

0:47:38.360 --> 0:47:42.480
<v Speaker 3>growth and reproduction. Oh okay, so secondary right.

0:47:44.400 --> 0:47:44.760
<v Speaker 1>Purpose?

0:47:45.040 --> 0:47:50.520
<v Speaker 3>Right? Yeah, whatever, it's secondary compounds are largely defense compounds,

0:47:51.000 --> 0:47:53.359
<v Speaker 3>and there's a lot of different ways a plant can

0:47:53.400 --> 0:47:55.720
<v Speaker 3>go to defend itself, and you got to think about

0:47:55.760 --> 0:47:58.560
<v Speaker 3>it from a plant's perspective, right, They're not animals they

0:47:58.600 --> 0:48:01.960
<v Speaker 3>can't run from danger. Plants are stuck where they are.

0:48:02.080 --> 0:48:04.920
<v Speaker 3>For the most part. There's exceptions to that rule. For

0:48:05.000 --> 0:48:08.600
<v Speaker 3>anyone listening that's a plant person here, we don't need

0:48:08.680 --> 0:48:11.320
<v Speaker 3>to talk about those. But yeah, if you're stuck in

0:48:11.360 --> 0:48:16.040
<v Speaker 3>a place and you're a tasty, nitrogen filled plant, things

0:48:16.040 --> 0:48:20.000
<v Speaker 3>are gonna want to eat you, and you, in the

0:48:20.160 --> 0:48:22.560
<v Speaker 3>plant sense, are going to need to defend yourself. And

0:48:22.760 --> 0:48:24.680
<v Speaker 3>one of the many ways that plants do that are

0:48:24.760 --> 0:48:28.640
<v Speaker 3>through very toxic chemical compounds, and that's where most of

0:48:28.760 --> 0:48:31.640
<v Speaker 3>secondary metabolites come in. When we talk about the collagen

0:48:31.680 --> 0:48:34.719
<v Speaker 3>survival of plant species. They're to either make you so

0:48:34.880 --> 0:48:37.200
<v Speaker 3>distasteful that nothing wants to eat you, or if something

0:48:37.280 --> 0:48:40.239
<v Speaker 3>makes that mistake, it's the last mistake it ever makes.

0:48:41.440 --> 0:48:43.239
<v Speaker 1>Very cool, Yeah, very cool.

0:48:43.440 --> 0:48:45.520
<v Speaker 3>The thing to keep in mind about alkaloids is that

0:48:45.560 --> 0:48:48.360
<v Speaker 3>they're nitrogen rich compounds. So these are usually plants that

0:48:48.480 --> 0:48:52.040
<v Speaker 3>come from good soils, right and so acononym is largely

0:48:52.120 --> 0:48:54.759
<v Speaker 3>a plant species in the northern hemisphere that's native to

0:48:54.960 --> 0:48:59.880
<v Speaker 3>temperate areas, mountainous areas, but generally pretty rich soil types.

0:49:00.960 --> 0:49:03.879
<v Speaker 3>Because it takes a lot to produce these compounds, right, Yeah,

0:49:04.080 --> 0:49:07.759
<v Speaker 3>you don't need to do it, or evolutionaries speaking, why

0:49:07.800 --> 0:49:10.000
<v Speaker 3>would you produce them if you didn't have to, right,

0:49:10.719 --> 0:49:13.800
<v Speaker 3>And the amount of energy and vital compounds that go

0:49:13.880 --> 0:49:16.279
<v Speaker 3>into making them kind of leeds into the fact that

0:49:16.360 --> 0:49:19.360
<v Speaker 3>they are very necessary for these plants long term survival.

0:49:19.920 --> 0:49:21.600
<v Speaker 3>So the big thing with these plants is that they

0:49:21.760 --> 0:49:24.200
<v Speaker 3>just simply don't want to be eaten. And that's what's

0:49:24.239 --> 0:49:26.960
<v Speaker 3>amazing about plant compounds, and that's something that humans have

0:49:27.120 --> 0:49:29.880
<v Speaker 3>used for centuries, is the fact that the compounds that

0:49:29.920 --> 0:49:33.080
<v Speaker 3>they're producing have to be biologically active. And this is

0:49:33.160 --> 0:49:36.040
<v Speaker 3>why I love your idea of like it's all in

0:49:36.120 --> 0:49:38.520
<v Speaker 3>the dose, right, what's a poison and what's a medicine? Well,

0:49:38.760 --> 0:49:40.920
<v Speaker 3>how much are you taking and why are you taking it? Right?

0:49:41.560 --> 0:49:45.080
<v Speaker 3>And that's key to this is that these plants don't

0:49:45.120 --> 0:49:47.320
<v Speaker 3>want to be eaten. Plants are trying to kill whatever's

0:49:47.320 --> 0:49:49.080
<v Speaker 3>eating them, or at least make them never want to

0:49:49.120 --> 0:49:51.600
<v Speaker 3>eat it again. And that's where these alkaloids start to

0:49:51.640 --> 0:49:54.839
<v Speaker 3>come into place. So ecologically, evolutionarily speaking, these are all

0:49:54.920 --> 0:49:57.520
<v Speaker 3>defense compounds, at least in the context of this. There's

0:49:57.560 --> 0:50:01.040
<v Speaker 3>probably other functions that we don't quite understand yet, because again,

0:50:01.080 --> 0:50:04.200
<v Speaker 3>the science is truly in its infancy in a lot

0:50:04.239 --> 0:50:07.359
<v Speaker 3>of ways. But it's fascinating to think about what these

0:50:07.360 --> 0:50:10.440
<v Speaker 3>plants are doing just to keep things from butting off pieces.

0:50:10.920 --> 0:50:12.680
<v Speaker 3>And that brings up a really good point here, is

0:50:12.760 --> 0:50:18.560
<v Speaker 3>that there's variations in the composition and concentration between species,

0:50:18.840 --> 0:50:23.000
<v Speaker 3>between individuals within a species, and even between parts of

0:50:23.120 --> 0:50:24.200
<v Speaker 3>the same plant.

0:50:24.680 --> 0:50:26.839
<v Speaker 2>Yeah, that was a big thing I saw when they

0:50:26.880 --> 0:50:31.000
<v Speaker 2>were like talking about people that use this in different remedies,

0:50:31.200 --> 0:50:32.200
<v Speaker 2>was like, are you using the.

0:50:32.280 --> 0:50:34.200
<v Speaker 1>Root or the stem or the leaves?

0:50:35.160 --> 0:50:38.600
<v Speaker 2>Does it also does the species variation? Does that depend

0:50:38.719 --> 0:50:43.680
<v Speaker 2>on like what organism is the primary consumer of that plant?

0:50:43.800 --> 0:50:47.840
<v Speaker 3>It's very much can. So you will often see plants

0:50:47.880 --> 0:50:51.440
<v Speaker 3>that get into areas where, say islands, where there aren't

0:50:51.520 --> 0:50:54.239
<v Speaker 3>large predators or mammals, don't make it too quite easily. Yeah,

0:50:54.320 --> 0:50:56.600
<v Speaker 3>you still have to deal with your insect constituency, but

0:50:56.760 --> 0:50:58.920
<v Speaker 3>you see kind of a reduction on a lot of compounds,

0:50:58.960 --> 0:51:01.600
<v Speaker 3>because why would you produce something if you didn't have to?

0:51:01.800 --> 0:51:05.000
<v Speaker 3>These are expensive products to produce, so why.

0:51:04.920 --> 0:51:07.640
<v Speaker 2>Make something that's strong enough to kill a mammal if

0:51:07.680 --> 0:51:10.239
<v Speaker 2>all you have to kill is like a grasshopper? Right,

0:51:10.280 --> 0:51:13.279
<v Speaker 2>which it probably it doesn't take nearly the concentration or

0:51:13.320 --> 0:51:15.439
<v Speaker 2>whatever to kill a grasshopper as.

0:51:15.320 --> 0:51:18.600
<v Speaker 1>It was into the whole energy budget. Yeah, one, am

0:51:18.600 --> 0:51:21.279
<v Speaker 1>I spending my energy.

0:51:21.080 --> 0:51:22.359
<v Speaker 2>On this is so fun?

0:51:22.480 --> 0:51:24.759
<v Speaker 3>Yes, I know. I love that the ecology side is

0:51:24.760 --> 0:51:27.920
<v Speaker 3>coming out right now. Yeah, but exactly, you've hit the

0:51:28.000 --> 0:51:31.480
<v Speaker 3>nail on the head, and we'll talk about insects and

0:51:31.880 --> 0:51:34.120
<v Speaker 3>just that evolutionary arms race in which you get around

0:51:34.200 --> 0:51:36.160
<v Speaker 3>those sorts of things. But again, all of these are

0:51:36.200 --> 0:51:41.399
<v Speaker 3>to deter herbivores to any extent possible. Yeah, So as

0:51:41.520 --> 0:51:44.160
<v Speaker 3>far that we know from what we've been able to

0:51:44.400 --> 0:51:48.800
<v Speaker 3>establish at this point of the fifty four phytochemically investigated

0:51:48.840 --> 0:51:51.480
<v Speaker 3>species of ecnodom So essentially that's just saying of the

0:51:51.560 --> 0:51:56.000
<v Speaker 3>fifty four species that we've decided to analyze the chemical composition,

0:51:57.560 --> 0:52:02.440
<v Speaker 3>they all contain a connoteam like alkaloids, which are neurotoxic,

0:52:02.560 --> 0:52:06.480
<v Speaker 3>as we decided cardiotoxic from mammals and insects. And it's

0:52:06.480 --> 0:52:11.640
<v Speaker 3>important to note that you're talking about sodium channels right raid.

0:52:12.160 --> 0:52:16.560
<v Speaker 3>Our favorite b spray also opens up those sodium channels

0:52:16.600 --> 0:52:17.960
<v Speaker 3>and that's the way in which it works.

0:52:18.040 --> 0:52:22.480
<v Speaker 2>So yeah, yeah, these sodium channels are highly conserved across

0:52:22.680 --> 0:52:24.000
<v Speaker 2>evolutionary tax.

0:52:24.280 --> 0:52:27.000
<v Speaker 3>Right, that's a very effective way to kill any sort

0:52:27.000 --> 0:52:31.239
<v Speaker 3>of living animal. Yeah, definitely, or again make it never

0:52:31.360 --> 0:52:31.960
<v Speaker 3>want to eat you.

0:52:32.600 --> 0:52:32.799
<v Speaker 1>Yeah.

0:52:33.920 --> 0:52:36.319
<v Speaker 3>So the fact that different organs can vary is pretty

0:52:36.360 --> 0:52:40.600
<v Speaker 3>interesting because the localization of these secondary metabolite says a

0:52:40.640 --> 0:52:43.560
<v Speaker 3>lot about from a survival standpoint, what these plants really

0:52:43.560 --> 0:52:47.160
<v Speaker 3>are trying to protect. So most of what you most

0:52:47.200 --> 0:52:49.839
<v Speaker 3>of the stuff you want to avoid with econodam, although

0:52:49.880 --> 0:52:52.920
<v Speaker 3>I recommend avoiding the whole freaking plant in terms of digestion.

0:52:53.560 --> 0:52:56.440
<v Speaker 3>Are the growth tips, so any part that's actively growing,

0:52:56.520 --> 0:53:01.239
<v Speaker 3>so a leaf, bud, the flowers, right, Reproduction is the

0:53:01.400 --> 0:53:04.160
<v Speaker 3>key to many sort of species.

0:53:04.280 --> 0:53:04.799
<v Speaker 2>That makes sense.

0:53:04.880 --> 0:53:06.560
<v Speaker 3>Yeah, So you want to protect the parts that.

0:53:06.719 --> 0:53:10.400
<v Speaker 2>Do that, so they should be the most dangerous the.

0:53:10.480 --> 0:53:13.360
<v Speaker 3>Roots because essentially a plant is nothing without its roots.

0:53:13.400 --> 0:53:16.360
<v Speaker 3>And most of the deaths that I encountered in my

0:53:16.560 --> 0:53:19.920
<v Speaker 3>trying to avoid encountering them were from people eating the tubers.

0:53:20.080 --> 0:53:25.719
<v Speaker 1>Yeah, what's left over at that point? So if you

0:53:25.840 --> 0:53:29.160
<v Speaker 1>are going to use aconite, use the stems, right, but

0:53:29.280 --> 0:53:30.719
<v Speaker 1>also don't use any part of it.

0:53:30.920 --> 0:53:34.279
<v Speaker 4>Just seem like if you're going to use it, think

0:53:34.320 --> 0:53:40.440
<v Speaker 4>of twice and don't yourself, right, But that brings up

0:53:40.480 --> 0:53:43.279
<v Speaker 4>a really interesting point because it's not just herbivores that

0:53:43.320 --> 0:53:45.120
<v Speaker 4>are interacting with these plants.

0:53:45.560 --> 0:53:48.200
<v Speaker 3>They're flowering plants. They're an angiosperm, and what do we

0:53:48.320 --> 0:53:49.680
<v Speaker 3>know about angiosperms?

0:53:50.719 --> 0:53:53.680
<v Speaker 2>Lots of flying bees, and pollinator.

0:53:57.560 --> 0:54:00.400
<v Speaker 1>Was like a wing thing to give us a cue,

0:54:00.680 --> 0:54:05.640
<v Speaker 1>he was flapping his hands. We got there eventually.

0:54:06.400 --> 0:54:09.000
<v Speaker 3>So when people started looking at the levels of these

0:54:09.080 --> 0:54:12.239
<v Speaker 3>toxic alkaloids, which again a conatine is just one of them.

0:54:12.440 --> 0:54:17.320
<v Speaker 3>There's at least ten different very toxic alkaloids to consider

0:54:17.400 --> 0:54:19.440
<v Speaker 3>when considering this plant. I don't know why we just

0:54:19.480 --> 0:54:22.719
<v Speaker 3>focus on one of them, regardless, when people looked at

0:54:22.840 --> 0:54:25.239
<v Speaker 3>which parts of the plant were producing that it made

0:54:25.239 --> 0:54:28.200
<v Speaker 3>a lot of sense because the highest levels you see

0:54:28.239 --> 0:54:30.840
<v Speaker 3>are in the roots. I brought. I brought a graph.

0:54:31.160 --> 0:54:31.880
<v Speaker 2>There's a graph.

0:54:33.760 --> 0:54:36.920
<v Speaker 3>First with the highest concentration are the roots. The second

0:54:37.080 --> 0:54:40.720
<v Speaker 3>is the pollen, third is the flower, so the flower

0:54:40.800 --> 0:54:43.800
<v Speaker 3>being the sepals and the petals the pollen, which is

0:54:43.960 --> 0:54:47.760
<v Speaker 3>really interesting because that's a floral reward, right, it's a gammy.

0:54:47.960 --> 0:54:49.720
<v Speaker 3>You need it to get from one plant to another

0:54:49.840 --> 0:54:54.920
<v Speaker 3>for sexual reproduction. But there's within reason. Yeah, but why

0:54:55.000 --> 0:54:58.439
<v Speaker 3>would a plant want to protect its pollen where that's

0:54:58.560 --> 0:55:00.560
<v Speaker 3>the key, you know, something needs to pick that up

0:55:00.600 --> 0:55:02.640
<v Speaker 3>and take it, usually a bee in this case, because

0:55:02.719 --> 0:55:05.759
<v Speaker 3>it's worth mentioning that most econodam are be pollinated to

0:55:05.840 --> 0:55:08.839
<v Speaker 3>the point that in Europe at least and in Asia too,

0:55:09.120 --> 0:55:12.680
<v Speaker 3>I think there are bees that pollinate nothing else, right,

0:55:13.080 --> 0:55:16.280
<v Speaker 3>that their entire life history overlaps only with the blooming

0:55:16.320 --> 0:55:19.840
<v Speaker 3>period of that specific monks of the species. So this

0:55:20.000 --> 0:55:22.960
<v Speaker 3>question became, why the hell are these plants putting this

0:55:23.200 --> 0:55:25.759
<v Speaker 3>in their pollen? And why is that second to you know,

0:55:26.320 --> 0:55:28.799
<v Speaker 3>the root, but then beats out the flour and the leaf,

0:55:28.800 --> 0:55:31.480
<v Speaker 3>which are parts you generally assume are pretty important for

0:55:31.520 --> 0:55:35.000
<v Speaker 3>a plant. Well, that brings up a really weird idea

0:55:35.120 --> 0:55:38.600
<v Speaker 3>of the fact that you know, certain insects start to

0:55:38.680 --> 0:55:42.960
<v Speaker 3>benefit from these compounds. Oh what Yeah, and this is

0:55:43.040 --> 0:55:46.960
<v Speaker 3>still largely hypothetical and remains to be tested, But think

0:55:46.960 --> 0:55:49.640
<v Speaker 3>about it this way. Everyone's really familiar with the monarch butterfly.

0:55:49.920 --> 0:55:52.560
<v Speaker 3>It eats milkweed, and part of what it does is

0:55:52.640 --> 0:55:54.920
<v Speaker 3>that milkweed is full of other alkaloids, which we can

0:55:55.040 --> 0:55:57.840
<v Speaker 3>talk about it in a later episode. But they sequester

0:55:58.000 --> 0:55:59.959
<v Speaker 3>those poisons, and all that means is that their storm

0:56:00.120 --> 0:56:03.839
<v Speaker 3>them in their tissues and that keeps birds from wanting

0:56:03.880 --> 0:56:05.680
<v Speaker 3>to eat the caterpillars and the butterflies.

0:56:05.760 --> 0:56:07.759
<v Speaker 2>Oh my god, this is so exciting.

0:56:08.719 --> 0:56:14.880
<v Speaker 3>It's extremely exciting because someone Goslin and others in twenty

0:56:15.080 --> 0:56:17.520
<v Speaker 3>thirteen put this idea to the test, and this was

0:56:17.560 --> 0:56:20.279
<v Speaker 3>a really cool one of the cools papers I found

0:56:20.320 --> 0:56:22.480
<v Speaker 3>in researching this, and it kind of comes down to

0:56:22.560 --> 0:56:25.560
<v Speaker 3>this idea of attraction versus protection. You want to protect

0:56:25.600 --> 0:56:28.040
<v Speaker 3>your parts that are really important to you, but you

0:56:28.160 --> 0:56:32.200
<v Speaker 3>also need to attract insect pollinators in this case. So

0:56:32.520 --> 0:56:34.680
<v Speaker 3>could it be that these bees are collecting the pollen,

0:56:34.960 --> 0:56:37.719
<v Speaker 3>feeding it to their offspring and it's questering at least

0:56:37.760 --> 0:56:40.360
<v Speaker 3>some of those alkaloids and their tissues. And what they

0:56:40.440 --> 0:56:44.719
<v Speaker 3>found is that, yes, it's happening. Now they do not

0:56:44.920 --> 0:56:47.719
<v Speaker 3>know if it's enough to deter potential predators on the

0:56:47.800 --> 0:56:52.839
<v Speaker 3>bees bees. But this concept of potentially reinforcing the fact

0:56:52.880 --> 0:56:56.400
<v Speaker 3>that you're bolstering and protecting your flowers but also kind

0:56:56.440 --> 0:56:59.040
<v Speaker 3>of encouraging your pollinators to keep coming back, that is

0:56:59.120 --> 0:57:02.560
<v Speaker 3>so cool. There's enough evidence to suggest that further work

0:57:02.600 --> 0:57:05.239
<v Speaker 3>should investigate this to it. That's really cool.

0:57:05.400 --> 0:57:06.759
<v Speaker 2>That is really cool.

0:57:06.880 --> 0:57:12.160
<v Speaker 1>And so just to like recap. Yeah, Like, so we're

0:57:12.280 --> 0:57:18.040
<v Speaker 1>talking about these bees being able to take these poisonous

0:57:18.120 --> 0:57:22.840
<v Speaker 1>things which are poisonous to so many vertebrates, so many arthropods,

0:57:23.080 --> 0:57:28.920
<v Speaker 1>so many animals, and use that to also be toxic

0:57:29.080 --> 0:57:30.200
<v Speaker 1>or poisonous.

0:57:29.720 --> 0:57:32.200
<v Speaker 2>So that if something eats them, then they're going to

0:57:32.240 --> 0:57:35.120
<v Speaker 2>get poisoned by that same poison that the plant made.

0:57:35.440 --> 0:57:35.960
<v Speaker 3>Exactly.

0:57:36.040 --> 0:57:36.800
<v Speaker 1>That's super cool.

0:57:36.840 --> 0:57:39.120
<v Speaker 3>This is an evolution at its best and why I'm

0:57:39.120 --> 0:57:39.880
<v Speaker 3>in the field that I'm in.

0:57:40.200 --> 0:57:41.520
<v Speaker 1>Yeah, that's really exciting.

0:57:42.040 --> 0:57:44.000
<v Speaker 3>So you've got this dual benefit, right, You've got this

0:57:44.440 --> 0:57:48.120
<v Speaker 3>poison in your very sensitive tissues that are protecting you

0:57:48.200 --> 0:57:51.240
<v Speaker 3>from generalists. Not to say things don't feed on these plants,

0:57:51.320 --> 0:57:53.920
<v Speaker 3>they do. There's I came across a list of plenty

0:57:53.960 --> 0:57:56.920
<v Speaker 3>of butterfly and maflar but that will feed on these plants.

0:57:57.360 --> 0:58:00.880
<v Speaker 3>Specialization goes both bays, right, Yeah. Yeah, but it reduces

0:58:00.920 --> 0:58:03.040
<v Speaker 3>the amount of animals that could potentially feed on you.

0:58:03.640 --> 0:58:06.280
<v Speaker 3>But then this also added benefit of reproducing or adding

0:58:06.320 --> 0:58:09.480
<v Speaker 3>to reproductive fitness by kind of helping out your so

0:58:09.640 --> 0:58:10.720
<v Speaker 3>called symbaiant in.

0:58:10.800 --> 0:58:13.720
<v Speaker 2>This case, that is so awesome.

0:58:14.480 --> 0:58:16.560
<v Speaker 3>These are really neat plants, and I'm so happy these

0:58:16.600 --> 0:58:19.760
<v Speaker 3>are the ones that we're covering. And that's not to

0:58:19.800 --> 0:58:22.000
<v Speaker 3>say that like the species we mentioned are the only

0:58:22.080 --> 0:58:24.680
<v Speaker 3>ones here that we're considering. I mean, a contodom is

0:58:24.760 --> 0:58:27.160
<v Speaker 3>a northern hemisphere species. We have them in North America.

0:58:27.240 --> 0:58:28.920
<v Speaker 3>Unfortunately a lot of ours are endangered.

0:58:29.920 --> 0:58:31.000
<v Speaker 1>Why are they endangered?

0:58:31.880 --> 0:58:35.520
<v Speaker 3>The ones in North America are largely due to habitat loss.

0:58:35.560 --> 0:58:37.960
<v Speaker 3>I mean, that's the number one reduction of any species

0:58:38.000 --> 0:58:39.800
<v Speaker 3>on this planet. It's the one thing we should be

0:58:39.840 --> 0:58:43.360
<v Speaker 3>fighting is just gobbling up habitat to preserve it instead

0:58:43.360 --> 0:58:46.400
<v Speaker 3>of to build malls on it. But so, the IUCN

0:58:46.480 --> 0:58:49.840
<v Speaker 3>red List, which is the International Union for Conservation of Nature,

0:58:50.400 --> 0:58:54.080
<v Speaker 3>lists at least a handful of Acnodum species as critically

0:58:54.280 --> 0:58:57.600
<v Speaker 3>or at least endangered on one level or another. So

0:58:57.720 --> 0:58:59.520
<v Speaker 3>a lot of them are the ones that are native

0:58:59.560 --> 0:59:03.800
<v Speaker 3>to the Himalayan region of India, Pakistan, and Nepal. And

0:59:03.920 --> 0:59:06.480
<v Speaker 3>what ends up happening there is this is where a

0:59:06.520 --> 0:59:09.800
<v Speaker 3>lot of the contention with herbalism practices comes from, right,

0:59:10.120 --> 0:59:12.760
<v Speaker 3>So I'm not trying to crap on anyone's culture That's

0:59:12.800 --> 0:59:14.920
<v Speaker 3>not what I'm doing here. I'm simply stating the facts.

0:59:15.040 --> 0:59:17.280
<v Speaker 3>Is that a lot of these species are important to

0:59:17.960 --> 0:59:22.520
<v Speaker 3>cultural practices, but any plants that become very popular or

0:59:22.640 --> 0:59:25.640
<v Speaker 3>very important than those cultures are obviously sought after. Right.

0:59:26.200 --> 0:59:29.120
<v Speaker 3>So the ICN Red List all of the species of

0:59:29.160 --> 0:59:32.720
<v Speaker 3>Econonym that they listed are endangered because of overharvesting for

0:59:32.880 --> 0:59:34.080
<v Speaker 3>these medicinal practices.

0:59:34.800 --> 0:59:38.760
<v Speaker 2>So it's not like they're growing their own to be harvested.

0:59:38.840 --> 0:59:40.640
<v Speaker 2>They're going out in the wild and harvesting.

0:59:40.920 --> 0:59:44.200
<v Speaker 3>Yes, And that's a sad fact about at least western erbalism,

0:59:44.280 --> 0:59:47.840
<v Speaker 3>is the fact that they value naturally sourced product over

0:59:48.240 --> 0:59:51.280
<v Speaker 3>product that has been grown horticulture. There are, at least

0:59:51.280 --> 0:59:56.360
<v Speaker 3>in an agricultural setting, which is very counterintuitive because one

0:59:56.400 --> 0:59:58.240
<v Speaker 3>thing is that despite the fact that these plants are

0:59:58.240 --> 1:00:02.080
<v Speaker 3>producing these compounds, fact that natural selection is what it is,

1:00:02.160 --> 1:00:04.000
<v Speaker 3>and you're not going to have the same pressures everywhere.

1:00:04.040 --> 1:00:07.760
<v Speaker 3>These compounds are not always in the same doses. Yeah,

1:00:07.920 --> 1:00:09.920
<v Speaker 3>So what ends up happening is, like we mentioned, not

1:00:10.080 --> 1:00:12.440
<v Speaker 3>all parts of the plant are as equally toxic, and

1:00:12.480 --> 1:00:15.640
<v Speaker 3>if you want to get the most potent, generally that

1:00:15.840 --> 1:00:18.360
<v Speaker 3>means harvesting the roots. So all of these plants are

1:00:18.960 --> 1:00:23.080
<v Speaker 3>taken roots and all. There's no regenitive capabilities once you've

1:00:23.120 --> 1:00:24.920
<v Speaker 3>harvested the root of a plant. So that's why a

1:00:24.960 --> 1:00:27.040
<v Speaker 3>lot of these are ended up being put on the

1:00:27.160 --> 1:00:31.000
<v Speaker 3>endangered species list is because you've harvested every chance this

1:00:31.120 --> 1:00:33.360
<v Speaker 3>plant has of coming back. And that's to me kind

1:00:33.360 --> 1:00:33.840
<v Speaker 3>of tragic.

1:00:34.040 --> 1:00:35.360
<v Speaker 1>I mean, it seems like one of the things that

1:00:35.440 --> 1:00:39.720
<v Speaker 1>we keep coming back to in this podcast is the

1:00:39.880 --> 1:00:44.120
<v Speaker 1>impact of urbanization and so like that in a vacuum

1:00:44.360 --> 1:00:49.400
<v Speaker 1>over harvesting cannot be possible without the habitat reduction at

1:00:49.400 --> 1:00:52.000
<v Speaker 1>the same time, and so it's a one to two

1:00:52.120 --> 1:00:56.600
<v Speaker 1>punch where we have these urban communities spreading into areas

1:00:56.720 --> 1:01:02.240
<v Speaker 1>and we have a lack of which in so many

1:01:02.320 --> 1:01:10.160
<v Speaker 1>cases it's it's not financially feasible. So like, yeah, it's

1:01:10.320 --> 1:01:15.320
<v Speaker 1>it's like this is it's almost an inevitable fact of urbanization.

1:01:15.600 --> 1:01:17.320
<v Speaker 3>The question then becomes this a is this is an

1:01:17.320 --> 1:01:20.520
<v Speaker 3>effective way of treating and is there educational ways of

1:01:20.560 --> 1:01:23.040
<v Speaker 3>getting past that? But then, as you mentioned, and I'm

1:01:23.080 --> 1:01:25.760
<v Speaker 3>really happy you did, is this idea of diminishing returns

1:01:25.800 --> 1:01:27.480
<v Speaker 3>And that is where my contention with a lot of

1:01:27.520 --> 1:01:31.000
<v Speaker 3>the foraging community comes from. It would be awesome if

1:01:31.040 --> 1:01:34.960
<v Speaker 3>everyone could adopt forging practices, if we had enough land

1:01:35.000 --> 1:01:39.640
<v Speaker 3>to support that, But unfortunately, this largely becomes a practice

1:01:39.680 --> 1:01:42.240
<v Speaker 3>of people that are comfortable in areas where there isn't

1:01:42.640 --> 1:01:45.400
<v Speaker 3>a lot of natural areas left. So as our natural

1:01:45.480 --> 1:01:48.680
<v Speaker 3>areas shrink and people take up this practice and go

1:01:48.800 --> 1:01:50.680
<v Speaker 3>into the forest and treat it like the bulk been

1:01:50.760 --> 1:01:53.200
<v Speaker 3>at your grocery store. This is something we're going to

1:01:53.240 --> 1:01:55.960
<v Speaker 3>see time and time again, and it's really important to

1:01:56.040 --> 1:01:58.360
<v Speaker 3>mention that you do not have to take every last

1:01:58.440 --> 1:02:01.680
<v Speaker 3>individual of a species to doom it to extinction. You

1:02:01.760 --> 1:02:04.800
<v Speaker 3>can reduce its genetic diversity or its population numbers to

1:02:05.000 --> 1:02:07.680
<v Speaker 3>levels in which they're just going to stagnate and die anyway.

1:02:07.720 --> 1:02:10.200
<v Speaker 3>And that's the fear with a lot of these medicinal plants.

1:02:11.000 --> 1:02:14.120
<v Speaker 2>Oh that was fun. Yeah, that was I learned a

1:02:14.320 --> 1:02:17.680
<v Speaker 2>crap ton, including what monks hood actually looks like.

1:02:19.000 --> 1:02:22.760
<v Speaker 3>A Once next fall comes around, I will happily show

1:02:22.760 --> 1:02:24.440
<v Speaker 3>you all of the monkshood in our neighborhood.

1:02:24.520 --> 1:02:25.480
<v Speaker 2>That would be so fun.

1:02:27.880 --> 1:02:37.000
<v Speaker 3>Time. Well, I learned a ton too. Thank you for

1:02:37.080 --> 1:02:39.120
<v Speaker 3>letting me exercise a set of muscles that I don't

1:02:39.200 --> 1:02:40.320
<v Speaker 3>generally get to exercises.

1:02:41.720 --> 1:02:43.440
<v Speaker 1>This was really great, super fun.

1:02:43.920 --> 1:02:48.280
<v Speaker 2>To all of the expectations, and we have multiple more episodes.

1:02:48.560 --> 1:02:52.720
<v Speaker 1>We have more coming to you, so I guess is

1:02:52.800 --> 1:02:53.280
<v Speaker 1>that all we have.

1:02:53.480 --> 1:02:55.680
<v Speaker 2>I think so we don't really need to tell you

1:02:55.760 --> 1:02:56.880
<v Speaker 2>to wash your hands this time.

1:02:57.160 --> 1:03:00.000
<v Speaker 1>Wash your plants, no boil your plant.

1:03:00.200 --> 1:03:03.040
<v Speaker 3>Don't eat everything you were growing, I think is probably

1:03:03.120 --> 1:03:04.520
<v Speaker 3>the better figure.

1:03:04.920 --> 1:03:07.480
<v Speaker 2>Don't eat that plant, you filthy animals.

1:03:07.560 --> 1:03:08.720
<v Speaker 1>Filthy animals,