WEBVTT - Lab 041: Out of Control

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<v Speaker 1>Last week, the Supreme Court started hearing the case about

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<v Speaker 1>abortion access in Mississippi. And this all started because Mississippi

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<v Speaker 1>put a law in place that said you couldn't terminate

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<v Speaker 1>your pregnancy after fifteen weeks.

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<v Speaker 2>Well, that's in direct contradiction with Roe v. Wade, right,

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<v Speaker 2>which says you can terminate a pregnancy up until twenty

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<v Speaker 2>four weeks, which is considered the point of viability, or

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<v Speaker 2>when a fetus can survive outside the womb.

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<v Speaker 3>Right.

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<v Speaker 1>And this is so monumental because this is the first

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<v Speaker 1>time since nineteen seventy three. So when Roe versus Wad

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<v Speaker 1>happened that the Supreme Court is hearing a case that

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<v Speaker 1>questions if it's constitutional to ban abortion before viability.

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<v Speaker 2>This feels like a lot is on the line.

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<v Speaker 1>Yeah, this could change everything, And it seems like we

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<v Speaker 1>are in a time machine because I never thought that

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<v Speaker 1>in my lifetime that we would go back to this

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<v Speaker 1>way of thinking and have to go through court systems

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<v Speaker 1>again about women's reproductive rights.

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<v Speaker 2>Yes, and you know, I've seen a lot of chatter,

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<v Speaker 2>you know, I like to scan the way. I've seen

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<v Speaker 2>a lot of chatter about like, oh, well, you don't

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<v Speaker 2>have to worry about abortion if you are taking birth

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<v Speaker 2>control and this and that, but baby, we need to

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<v Speaker 2>talk about birth control.

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<v Speaker 1>Absolutely, because not all that glitters is gold. It's not

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<v Speaker 1>some magic pill that works for everybody the exact same way.

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<v Speaker 3>So we have to talk about this.

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<v Speaker 1>Welcome to Dope Labs, a weekly podcast that mixes hardcore science,

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<v Speaker 1>pop culture, and a healthy dosa friendship.

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<v Speaker 2>Reproductive rights have been under attack in the United States

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<v Speaker 2>and with the recent abortion legislation in Texas.

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<v Speaker 3>Right, it's not just Mississippi.

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<v Speaker 1>Texas has also put some laws in place, so they

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<v Speaker 1>have the Texas Heartbeat Act. And in this act, it

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<v Speaker 1>says that you can't terminate a pregnancy after six weeks,

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<v Speaker 1>So you only have six weeks to terminate your pregnancy.

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<v Speaker 2>And that six weeks is not from when you know

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<v Speaker 2>that you're pregnant. We need to be really clear. It

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<v Speaker 2>is tricky because the six weeks is from the date

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<v Speaker 2>of your last minstral cycle, so a lot of people

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<v Speaker 2>don't even know that they're pregnant six weeks out.

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<v Speaker 3>That's right.

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<v Speaker 1>So this week we're talking all about birth control specifically.

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<v Speaker 1>We wanted to understand how it works to prevent pregnancy.

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<v Speaker 1>Some of the issues or side effects around birth control

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<v Speaker 1>and how people can be empowered to find the best

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<v Speaker 1>option for them.

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<v Speaker 2>Let's get into the recitation. Okay, so what do we know?

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<v Speaker 4>Well, we know not all.

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<v Speaker 2>Birth control is created equal, right, you know there's a

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<v Speaker 2>lot of different types.

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<v Speaker 1>Yes, me and all my friends have all had a

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<v Speaker 1>different one and have different thoughts about each of those things.

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<v Speaker 2>Yeah, the pill, the ring shot, iud's condoms, even spermicide

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<v Speaker 2>seems like that's making a comeback.

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<v Speaker 4>I recently saw ad for that.

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<v Speaker 1>Do you remember that episode of Seinfeld where Elaine was

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<v Speaker 1>talking about the sponge. I had no idea what that

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<v Speaker 1>was when I was watching Seinfeld as a kid, but

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<v Speaker 1>it was birth control and she was trying to get

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<v Speaker 1>her hands on her favorite type of birth control, and it.

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<v Speaker 3>Was like she was looking for drug. Really, it was

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<v Speaker 3>very funny.

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<v Speaker 4>Now I'm gonna have to go back and look bit it.

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<v Speaker 4>What else do we know?

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<v Speaker 1>We know that birth control is an important topic because

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<v Speaker 1>half the population is looking for ways to decide.

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<v Speaker 3>Or control when they get pregnant.

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<v Speaker 4>Or if or if so.

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<v Speaker 2>What this boils down to is that birth control is

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<v Speaker 2>affecting a lot of the population.

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<v Speaker 1>Yeah, so many people just think of birth control as

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<v Speaker 1>something that people with uteruses are thinking about, when really

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<v Speaker 1>it can be partners that are thinking about it. So

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<v Speaker 1>it really does affect way more than just the person

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<v Speaker 1>with the uterus. Yes, but it seems like a lot

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<v Speaker 1>of people that don't have a uterus are making decisions

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<v Speaker 1>about it, sticking the non uterus in our business and

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<v Speaker 1>telling us what we should be doing with our uterus.

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<v Speaker 2>We also know there isn't a birth control pill for

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<v Speaker 2>men right now, so what's going on with that? So

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<v Speaker 2>what do we want to know?

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<v Speaker 1>I think for me, it kind of starts at the

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<v Speaker 1>base and I'm a little bit embarrassed.

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<v Speaker 4>This is a safe space.

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<v Speaker 3>I don't really know how birth control works. You're just

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<v Speaker 3>counting on it to work.

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<v Speaker 1>I think I kind of understand how the ring and

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<v Speaker 1>the pill work, but iud's I know there's different types,

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<v Speaker 1>and I think that's the part that I'm like, chemically,

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<v Speaker 1>what is going on with these contraptions that we could

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<v Speaker 1>possibly be putting inside of our bodies.

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<v Speaker 4>That's a good question.

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<v Speaker 2>And then just as deserving of conversation is what are

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<v Speaker 2>some of the side effects?

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<v Speaker 3>Right?

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<v Speaker 2>What are some of the issues that come along with

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<v Speaker 2>adding these things to your body? You know absolutely, because

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<v Speaker 2>we already know that there are side effects.

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<v Speaker 3>I think we've all heard. I just want to know

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<v Speaker 3>what are all of them?

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<v Speaker 2>Yeah, and piggybacking off what you just said, we know

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<v Speaker 2>there are tons of issues, and the issues are different

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<v Speaker 2>for different types of birth control. So how our doctors

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<v Speaker 2>to who gets what and when? And is the birth

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<v Speaker 2>control you got back in the day the same birth

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<v Speaker 2>control you should be using later, like people in birth

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<v Speaker 2>control for a long time.

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<v Speaker 1>Yeah, and our bodies are changing. We know that, right,

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<v Speaker 1>isn't one size fits all. Sometimes I feel like you're

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<v Speaker 1>going to the doctor and they just got the birth

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<v Speaker 1>control in a candy jar and they're just like here,

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<v Speaker 1>now go halfway. And then I think another really good

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<v Speaker 1>question is what is the future of birth control? I

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<v Speaker 1>can't imagine that we all gonna just be doing the

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<v Speaker 1>same thing.

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<v Speaker 3>I hope forever.

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<v Speaker 1>I hope that there's some advances in the technology so

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<v Speaker 1>that there aren't these issues that we're gonna be talking

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<v Speaker 1>about that persist with people whoever uterus.

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<v Speaker 3>Right, I feel like this is ripe for disruption.

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<v Speaker 1>Oh, absolutely, absolutely, all right, let's jump into the dissection.

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<v Speaker 2>Our guest for today's lab is doctor Elizabeth Rousseau.

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<v Speaker 5>I am Elizabeth Rousseau.

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<v Speaker 6>I am founder of AIDA, and I got my PhD

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<v Speaker 6>in human genetics at Duke University.

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<v Speaker 1>So me and Zakiah both went to Duke with Elizabeth.

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<v Speaker 1>Not just all we were there at the same time

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<v Speaker 1>and we might have met each other.

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<v Speaker 2>No, we actually know Elizabeth, yes, very very well. We

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<v Speaker 2>graduated from the same program. All right, we have the

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<v Speaker 2>same degree. So I am really excited to talk to

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<v Speaker 2>her today. Yes, and she's one of our very very

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<v Speaker 2>smart friends. So buck Lynn, so you can know you

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<v Speaker 2>hear us say, Elizabeth is doctor Ruzzo. Yes, put some

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<v Speaker 2>respect on her name. Let's start with the basics. So first,

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<v Speaker 2>there's ovulation. That's the release of an egg from your

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<v Speaker 2>ovary down the fallopian tube. So when that egg is fertilized,

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<v Speaker 2>it implants in the side of the uterus. If there

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<v Speaker 2>is no fertilized egg in that house, the uterus just

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<v Speaker 2>comes crashing down. It shares the lining, and that's the

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<v Speaker 2>twenty eight day cycle that we know is a mistral cycle,

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<v Speaker 2>and so that lining being shared, that's a period.

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<v Speaker 1>We know that birth control is a really important part

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<v Speaker 1>of reproductive health for so many people, and we know

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<v Speaker 1>it prevents pregnancy, but how exactly does it work.

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<v Speaker 6>The highly effective methods work by either preventing ovulation or

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<v Speaker 6>by preventing the sperm from successfully fertilizing the egg, which

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<v Speaker 6>is usually via thickening of the cervical mucus.

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<v Speaker 5>So, with the exception of the.

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<v Speaker 6>Copper IUD, they all work by adding low levels of

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<v Speaker 6>exogenous hormones. And these are specifically synthetic forms of either

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<v Speaker 6>estrogen or progesterone.

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<v Speaker 4>All right, so let's break that down.

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<v Speaker 1>Okay, good, because there are some words in there. I

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<v Speaker 1>don't I'm not sure.

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<v Speaker 2>So Elizabeth said that all of these, except for the

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<v Speaker 2>copper IUDs, work by adding exogenous hormones. XO means outside

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<v Speaker 2>in genous. You know, word genus is the origin, so

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<v Speaker 2>originating from outside the body.

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<v Speaker 3>My girl speak Latin. She speaks Latin, y'all.

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<v Speaker 2>And so all we think about it, we're saying, like progestin,

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<v Speaker 2>that's just a synthetic version of progesterone. Hormones are chemical messengers,

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<v Speaker 2>and they're like long range chemical messengers. They can travel

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<v Speaker 2>through the bloodstream, reach different organs. They're important, and they

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<v Speaker 2>all serve different purposes often and I think it's a

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<v Speaker 2>really delicate dance of the different hormones, which is why

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<v Speaker 2>you often hear people say, oh, it's a hormonal imbalance

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<v Speaker 2>because they're coregulated and some are blocking others, some amplify others,

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<v Speaker 2>and it happens at different times depending on different things

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<v Speaker 2>that are happening in your body.

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<v Speaker 1>It sounds like a symphony, like those strings come in

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<v Speaker 1>at the right time to drown out those woodwind instruments.

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<v Speaker 3>There you go.

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<v Speaker 2>So some of the hormones that these different breath controls

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<v Speaker 2>add in are estrogen and progestin. Let's start with estrogen.

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<v Speaker 2>This is something that's pretty cyclical. It follows the menstrual cycle.

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<v Speaker 2>Estrogen thickens the lining of your uterus. That's saying, hey,

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<v Speaker 2>get thick there's an egg that might get fertilized and

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<v Speaker 2>it needs to be implanted into the side of here, right.

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<v Speaker 1>It's trying to make that environment right for the fertilization, Yes,

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<v Speaker 1>the fertilization right, okay.

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<v Speaker 2>Right, And so hormonal birth control can prevent pregnancy by

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<v Speaker 2>preventing ovulation. And that's just simply humpty dumpty coming tumbling down.

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<v Speaker 2>That's an egg tumbling down through the uterus. Right, and

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<v Speaker 2>so you can prevent ovulation or you can say, all right,

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<v Speaker 2>in the cervix. You know, if we're thinking about what

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<v Speaker 2>reproduction is, what fertilization of an egg is, You're gonna

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<v Speaker 2>have to have sperm that can move through the mucus

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<v Speaker 2>on the cervix to fertilize an egg. So if you

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<v Speaker 2>make that mucus very thick, the sperm can't move through, right,

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<v Speaker 2>and so it's not able to enter the uterus, and

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<v Speaker 2>it's not able to fertilize the egg.

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<v Speaker 3>It's like quicksand for the sperm.

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<v Speaker 2>Yeah, the sperm is just not strong enough. Or another

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<v Speaker 2>way is to thin the lining of the uterus to

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<v Speaker 2>prevent the egg from even attaching to it. So slipping

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<v Speaker 2>slide records no egg attaching to the uterine lining, right,

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<v Speaker 2>if you want to remember it.

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<v Speaker 3>Those are different ways.

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<v Speaker 1>Okay, that was a beautiful breakdown of how all this works.

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<v Speaker 1>Doctor Russeau also mentioned the copper iud, which is a

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<v Speaker 1>non hormonal type of birth control.

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<v Speaker 3>So how does that method.

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<v Speaker 6>Work that one releases copper ions into the uterus and

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<v Speaker 6>makes it inhospitable for sperm and can potentially also prevent

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<v Speaker 6>implantation of the egg.

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<v Speaker 2>So, like we said before, there are so many types

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<v Speaker 2>of birth control. The pill, the patch, the shot, the implant.

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<v Speaker 2>Those are all hormonal types of birth control.

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<v Speaker 1>Non hormonal types include the copper ud using condoms in

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<v Speaker 1>the Fertility Awareness method also known as FAM, or the

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<v Speaker 1>rhythm method. This involves tracking changes during the menstrual cycle

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<v Speaker 1>to predict when you ovulate.

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<v Speaker 2>And the ways to use the different methods also vary,

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<v Speaker 2>so for the pill you take it daily at the

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<v Speaker 2>same time every day, whereas with the patch that's every

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<v Speaker 2>week you're applying a new patch.

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<v Speaker 1>So birth control has proved to be extremely effective at

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<v Speaker 1>preventing the fertilization or implantation of an egg in the uterus,

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<v Speaker 1>but it also has some reproductive health benefits beyond preventing pregnancy.

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<v Speaker 2>I think the point we really need to make clear

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<v Speaker 2>is that just having a uterus makes you susceptible to

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<v Speaker 2>all kinds of things.

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<v Speaker 1>Yes, like uterine fibroids, pcos PMDD, endometriosis.

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<v Speaker 2>Yes, And so I think it's easy to think of

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<v Speaker 2>birth control as just providing agency about when you will

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<v Speaker 2>or will not have a fertilized egg, but it's also

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<v Speaker 2>medicine for those other conditions that come along with having

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<v Speaker 2>a uterus.

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<v Speaker 4>Right.

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<v Speaker 1>Birth control can't cure these issues, but they do help

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<v Speaker 1>alleviate some of the symptoms that come with them.

0:11:38.800 --> 0:11:43.280
<v Speaker 6>It's also used as medicine to treat chronic reproductive disorders

0:11:43.320 --> 0:11:48.600
<v Speaker 6>in women, everything from menstrual cramps to fibroids to pcos.

0:11:48.760 --> 0:11:51.120
<v Speaker 1>Yeah, I've known people who are having issues with their period.

0:11:51.240 --> 0:11:54.120
<v Speaker 1>I knew someone that had their period consistently for like

0:11:54.200 --> 0:11:58.880
<v Speaker 1>six months, and so the prescribed medication to help regulate

0:11:58.920 --> 0:12:02.199
<v Speaker 1>it was birth control, And they had to go kind

0:12:02.240 --> 0:12:04.760
<v Speaker 1>of like back and forth with their doctors trying to

0:12:04.760 --> 0:12:07.720
<v Speaker 1>figure out the right dosage and things like that. But

0:12:07.760 --> 0:12:10.160
<v Speaker 1>eventually they got to a solution, which they were really

0:12:10.200 --> 0:12:10.800
<v Speaker 1>happy about.

0:12:10.960 --> 0:12:12.960
<v Speaker 2>I'm glad it worked out for them. There has been

0:12:13.080 --> 0:12:16.880
<v Speaker 2>so much conversation about fibroids, and these are not just

0:12:17.080 --> 0:12:20.440
<v Speaker 2>one off issues, right. So uterine fibroids, which are like

0:12:20.520 --> 0:12:23.800
<v Speaker 2>growths on the uterus. By the age of fifty, almost

0:12:23.840 --> 0:12:27.719
<v Speaker 2>two thirds of all women will have experienced uterine fibroids.

0:12:28.040 --> 0:12:28.240
<v Speaker 3>Right.

0:12:28.440 --> 0:12:31.400
<v Speaker 2>And then, even when we know how many women are

0:12:31.760 --> 0:12:35.680
<v Speaker 2>going to have fibroids, there are still disparities within those groups.

0:12:35.720 --> 0:12:38.920
<v Speaker 2>So for black women, between the age of eighteen and thirty,

0:12:39.040 --> 0:12:42.439
<v Speaker 2>about a quarter of them will experience uterine fibroids, compared

0:12:42.480 --> 0:12:45.200
<v Speaker 2>to six percent of white women in that same age range.

0:12:45.280 --> 0:12:48.720
<v Speaker 1>And then PCOS, which is polycystic ovarian syndrome.

0:12:48.960 --> 0:12:51.719
<v Speaker 3>That's a condition where your ovaries produce.

0:12:51.440 --> 0:12:55.920
<v Speaker 1>An abnormal amount of androgens, which is male sex hormones

0:12:56.120 --> 0:12:59.400
<v Speaker 1>that are usually present in women in only small amounts.

0:13:00.120 --> 0:13:03.480
<v Speaker 1>Having more of those hormones, it starts to produce little

0:13:03.559 --> 0:13:05.000
<v Speaker 1>cysts on your ovaries.

0:13:05.200 --> 0:13:09.000
<v Speaker 2>And so endometriosis something that we often hear about and

0:13:09.040 --> 0:13:11.800
<v Speaker 2>the difficulties related to this. When you're pregnant, that's when

0:13:11.840 --> 0:13:15.319
<v Speaker 2>that uterine lining that we talked about earlier grows outside

0:13:15.720 --> 0:13:18.440
<v Speaker 2>of the uterus. Oh my gosh, okay, and so that

0:13:18.480 --> 0:13:19.600
<v Speaker 2>can be really painful.

0:13:19.840 --> 0:13:25.240
<v Speaker 1>And then PMDD is pre menstrual dysphork disorder and it's

0:13:25.280 --> 0:13:28.840
<v Speaker 1>a lot more severe than what we call PMS.

0:13:29.160 --> 0:13:31.600
<v Speaker 2>So now that we have a solid understanding of first

0:13:31.720 --> 0:13:35.319
<v Speaker 2>how birth control works, second the different types of birth control,

0:13:35.360 --> 0:13:38.800
<v Speaker 2>and third the additional health benefits of birth control, let's

0:13:38.800 --> 0:13:42.000
<v Speaker 2>talk about how you actually get it, how is it prescribed?

0:13:42.400 --> 0:13:45.200
<v Speaker 2>So first things first, how many different brands or versions

0:13:45.240 --> 0:13:47.480
<v Speaker 2>of birth control do you think are currently on the market?

0:13:47.480 --> 0:13:53.880
<v Speaker 1>TT okay, I feel like there's probably more than I think,

0:13:54.160 --> 0:13:56.719
<v Speaker 1>maybe more than fifty, but less than a thousand. I'm

0:13:56.760 --> 0:13:59.960
<v Speaker 1>just gonna give a wide range. I like that very easy,

0:14:01.000 --> 0:14:01.400
<v Speaker 1>Thank you.

0:14:01.640 --> 0:14:03.640
<v Speaker 2>Yes, I mean it's hard when you really think about it,

0:14:03.640 --> 0:14:05.920
<v Speaker 2>because it feels like there's a lot of different categories

0:14:05.960 --> 0:14:07.880
<v Speaker 2>and it has to be more than one brand in

0:14:07.960 --> 0:14:09.439
<v Speaker 2>each of those categories, right.

0:14:09.320 --> 0:14:11.800
<v Speaker 1>Yeah, Because you know, when you go into any drug store,

0:14:11.920 --> 0:14:15.040
<v Speaker 1>you got talent all, then you got ibuprofen, and then

0:14:15.040 --> 0:14:17.560
<v Speaker 1>you got the CVS brand, you got this other brand

0:14:17.600 --> 0:14:20.520
<v Speaker 1>and children's brand, all these different types of things. So

0:14:20.520 --> 0:14:21.960
<v Speaker 1>I'm like, is birth control like that?

0:14:22.080 --> 0:14:22.160
<v Speaker 5>All?

0:14:22.240 --> 0:14:22.400
<v Speaker 3>Right?

0:14:22.440 --> 0:14:23.880
<v Speaker 4>So how many are there on the market.

0:14:24.040 --> 0:14:27.240
<v Speaker 6>It's one hundred and eighty one, so the vast majority

0:14:27.280 --> 0:14:30.040
<v Speaker 6>of those are in the category of pill. But even

0:14:30.080 --> 0:14:33.440
<v Speaker 6>within pill, there's multiple different kinds. So for example, some

0:14:33.600 --> 0:14:37.280
<v Speaker 6>have both estrogen and progestines and some are progestin only

0:14:37.400 --> 0:14:38.840
<v Speaker 6>or commonly called the mini pill.

0:14:39.120 --> 0:14:40.920
<v Speaker 4>I feel like your guess was good.

0:14:41.840 --> 0:14:43.920
<v Speaker 3>It definitely fell within the range that I had said.

0:14:44.000 --> 0:14:44.480
<v Speaker 3>Thank you.

0:14:44.560 --> 0:14:46.720
<v Speaker 2>I appreciate that, and you're right, I mean, it's not

0:14:46.800 --> 0:14:49.560
<v Speaker 2>quite a set of menifit, but birth control that includes

0:14:49.600 --> 0:14:51.840
<v Speaker 2>you know, brand names as well as the generic options

0:14:51.840 --> 0:14:53.160
<v Speaker 2>too that might be more affordable.

0:14:53.320 --> 0:14:56.120
<v Speaker 1>Yeah, and the mini pill, which is progestin only, is

0:14:56.160 --> 0:14:59.160
<v Speaker 1>typically given the people who are breastfeeding or at risk

0:14:59.240 --> 0:15:01.920
<v Speaker 1>for blood clot And all of these methods have different

0:15:02.000 --> 0:15:06.040
<v Speaker 1>levels of effectiveness. After abstinence and sterilization, the implants and

0:15:06.080 --> 0:15:09.960
<v Speaker 1>id's are the most effective methods of birth control, all

0:15:10.000 --> 0:15:12.640
<v Speaker 1>about ninety nine percent effective or better.

0:15:12.760 --> 0:15:15.000
<v Speaker 2>And that makes sense because both of those have a

0:15:15.040 --> 0:15:17.360
<v Speaker 2>lot less room for human error. Once it's in, it's

0:15:17.360 --> 0:15:20.400
<v Speaker 2>in well for the most part. Methods like the pill

0:15:20.480 --> 0:15:23.840
<v Speaker 2>of the patch. Now that's going to require you to

0:15:23.880 --> 0:15:27.120
<v Speaker 2>stick to a regular schedule and to always remember to

0:15:27.240 --> 0:15:29.520
<v Speaker 2>take whatever your method is or to apply your method,

0:15:29.560 --> 0:15:31.960
<v Speaker 2>and that is way more susceptible to human error.

0:15:32.040 --> 0:15:33.800
<v Speaker 1>There is one time I forgot to put my own

0:15:33.840 --> 0:15:36.880
<v Speaker 1>shoes on when I was leaving my apartment in grad school,

0:15:37.160 --> 0:15:40.000
<v Speaker 1>and I didn't realize until I turned on my car

0:15:40.120 --> 0:15:41.560
<v Speaker 1>and stepped on the break.

0:15:41.640 --> 0:15:43.920
<v Speaker 4>You put your foot to the pedal because.

0:15:43.720 --> 0:15:47.040
<v Speaker 1>It's like, this does not feel right, hm, So you

0:15:47.080 --> 0:15:49.040
<v Speaker 1>already know things are getting for god Ton.

0:15:49.240 --> 0:15:51.320
<v Speaker 4>So that gets us to the question of which method

0:15:51.400 --> 0:15:51.800
<v Speaker 4>is best?

0:15:52.000 --> 0:15:54.880
<v Speaker 1>For real, the best method is one that fits your lifestyle, right,

0:15:54.920 --> 0:15:57.040
<v Speaker 1>But I don't know if doctors are asking those specific

0:15:57.080 --> 0:15:58.720
<v Speaker 1>lifestyle questions like are.

0:15:58.640 --> 0:15:59.640
<v Speaker 3>You a forgetful person?

0:16:00.560 --> 0:16:00.800
<v Speaker 2>Right?

0:16:00.880 --> 0:16:02.680
<v Speaker 3>Have you ever gotten to your car without your shoes?

0:16:02.960 --> 0:16:03.640
<v Speaker 3>You know what I mean?

0:16:03.720 --> 0:16:08.560
<v Speaker 2>Because that is crazy levels of forgetfulness to me, right, yeah,

0:16:08.760 --> 0:16:10.880
<v Speaker 2>and something that even if you are forgetful person, you

0:16:10.960 --> 0:16:12.600
<v Speaker 2>might not even consider it because it's your day to.

0:16:12.600 --> 0:16:14.560
<v Speaker 4>Day life that might not feel forgetful to you.

0:16:14.640 --> 0:16:17.440
<v Speaker 2>I mean, yes, no shoes, but like oh man, where

0:16:17.440 --> 0:16:18.920
<v Speaker 2>you're having to say like did I turn off the stove?

0:16:18.960 --> 0:16:19.680
<v Speaker 4>Did I turn off to this?

0:16:19.760 --> 0:16:20.440
<v Speaker 3>You know? Right?

0:16:20.480 --> 0:16:23.080
<v Speaker 1>And maybe taking something every day and you set your

0:16:23.120 --> 0:16:25.400
<v Speaker 1>alarm on your phone and it's easy for you and

0:16:25.440 --> 0:16:27.600
<v Speaker 1>so it's no problem at all. But some people want

0:16:27.640 --> 0:16:29.640
<v Speaker 1>to be able to take breaks, like with the pill

0:16:29.800 --> 0:16:30.440
<v Speaker 1>and the patch.

0:16:30.720 --> 0:16:32.360
<v Speaker 4>Yeah, that makes complete sense.

0:16:32.520 --> 0:16:35.520
<v Speaker 1>Some people might be sensitive to hormonal changes, so they

0:16:35.640 --> 0:16:39.080
<v Speaker 1>don't want to opt for birth control that will change

0:16:39.080 --> 0:16:41.720
<v Speaker 1>their homeowned levels, so then they opt for you know,

0:16:41.760 --> 0:16:44.800
<v Speaker 1>things like condoms, the rhythm method or the copper UD.

0:16:45.280 --> 0:16:47.320
<v Speaker 2>So when you consider all this stuff, there's so many

0:16:47.360 --> 0:16:49.800
<v Speaker 2>options to pick from. One hundred and eighty one different ones.

0:16:49.840 --> 0:16:50.280
<v Speaker 4>It seems.

0:16:50.680 --> 0:16:54.040
<v Speaker 2>How are doctors deciding who gets which type of birth control?

0:16:54.120 --> 0:16:55.400
<v Speaker 5>It's complicated, right.

0:16:55.560 --> 0:16:59.200
<v Speaker 6>The average contraceptive counseling appointment in the US is thirteen

0:16:59.280 --> 0:17:04.080
<v Speaker 6>minutes thirteen minutes, and so doctors kind of prescribe based

0:17:04.119 --> 0:17:07.040
<v Speaker 6>on what they're comfortable with, what they've seen work in

0:17:07.080 --> 0:17:09.560
<v Speaker 6>their practice, and anecdotally a lot of them are like,

0:17:09.600 --> 0:17:11.280
<v Speaker 6>you know, I kind of have a couple favors. I

0:17:11.359 --> 0:17:13.880
<v Speaker 6>start with those. If they don't work, we go back

0:17:13.880 --> 0:17:16.639
<v Speaker 6>to it. And so this creates this process of women

0:17:16.720 --> 0:17:20.840
<v Speaker 6>and their doctors going through potentially years of trial and error.

0:17:20.920 --> 0:17:24.080
<v Speaker 6>The majority of women try for or more methods, with

0:17:24.160 --> 0:17:27.200
<v Speaker 6>the main reason that they quit being unwanted side effects.

0:17:27.320 --> 0:17:30.280
<v Speaker 1>So you heard that, right, Years years just to figure

0:17:30.280 --> 0:17:33.159
<v Speaker 1>out the right birth control. A lot can happen in

0:17:33.240 --> 0:17:36.000
<v Speaker 1>a year, and imagine having to go through that.

0:17:36.000 --> 0:17:37.440
<v Speaker 3>That's so frustrating.

0:17:37.840 --> 0:17:41.200
<v Speaker 6>Certain ones have different pros and cons right, Like, some

0:17:41.280 --> 0:17:44.800
<v Speaker 6>of them are also known to and have FDA approval

0:17:44.840 --> 0:17:47.600
<v Speaker 6>for being used in the treatment of acne. Some are

0:17:47.680 --> 0:17:51.840
<v Speaker 6>great at managing heavy menstrual bleeding, and others aren't. If

0:17:51.880 --> 0:17:53.840
<v Speaker 6>a patient comes in with like a this is my

0:17:53.960 --> 0:17:58.040
<v Speaker 6>main complaint or issue or concern on top of preventing pregnancy.

0:17:58.520 --> 0:18:01.119
<v Speaker 6>Then yes, doctors kind of know which of the bins

0:18:01.160 --> 0:18:01.919
<v Speaker 6>to pull from.

0:18:02.000 --> 0:18:05.919
<v Speaker 1>Doctor Russeau told us about the US Medical Eligibility Criteria

0:18:06.040 --> 0:18:09.320
<v Speaker 1>or US MECH for contraceptive Use, which lists out some

0:18:09.480 --> 0:18:12.480
<v Speaker 1>dangerous combinations of birth control and patient criteria.

0:18:12.720 --> 0:18:15.160
<v Speaker 6>So, for example, if you're a smoker over thirty five,

0:18:15.359 --> 0:18:18.719
<v Speaker 6>you should avoid combined oral contraceptives because they increase your

0:18:18.800 --> 0:18:21.240
<v Speaker 6>risk of blood clot and stroke things like that.

0:18:21.440 --> 0:18:23.680
<v Speaker 2>But even with that said, it's really a crapshoot and

0:18:23.720 --> 0:18:27.720
<v Speaker 2>there's no way to predict the possibility of unwanted side effects.

0:18:27.920 --> 0:18:30.120
<v Speaker 1>Yeah, cause, I mean I feel like most people are

0:18:30.160 --> 0:18:32.160
<v Speaker 1>walking into the doctor and just saying, hey, I need

0:18:32.200 --> 0:18:34.919
<v Speaker 1>birth control, and you might not even necessarily know to

0:18:35.080 --> 0:18:38.640
<v Speaker 1>think about some other things that might affect your reaction

0:18:38.880 --> 0:18:41.399
<v Speaker 1>to a certain type of birth control. I know I didn't.

0:18:41.440 --> 0:18:43.399
<v Speaker 1>I just said, hey, looking for the birth control. You

0:18:43.440 --> 0:18:44.040
<v Speaker 1>got some here.

0:18:44.119 --> 0:18:47.520
<v Speaker 2>So when we talk about these side effects, they really

0:18:47.920 --> 0:18:51.000
<v Speaker 2>span the total range of something that feels inconvenient like

0:18:51.000 --> 0:18:55.159
<v Speaker 2>a headache or nausea, to full blown migraines, changes in

0:18:55.240 --> 0:18:58.399
<v Speaker 2>period weight gain, changes in your mood, or sex drive,

0:18:59.040 --> 0:19:02.920
<v Speaker 2>blood clots, high blood pressure. I mean the list goes on, right,

0:19:03.080 --> 0:19:05.280
<v Speaker 2>even when you look at when there's a birth control

0:19:05.280 --> 0:19:07.159
<v Speaker 2>commercial at the end, when you know, when the person's

0:19:07.160 --> 0:19:08.440
<v Speaker 2>talking off fast and they're telling you all the side

0:19:08.440 --> 0:19:09.880
<v Speaker 2>of us, so you're staying in the really you can't

0:19:09.920 --> 0:19:11.680
<v Speaker 2>even catch onto it and the bla blah blah blah blah.

0:19:11.800 --> 0:19:13.200
<v Speaker 3>Yeah, all those things I listened in there.

0:19:13.240 --> 0:19:18.119
<v Speaker 1>They're like depression, suicidal thoughts, and I'm like, wow, uh

0:19:18.160 --> 0:19:19.800
<v Speaker 1>what you know.

0:19:20.240 --> 0:19:21.119
<v Speaker 3>It's just crazy.

0:19:21.160 --> 0:19:22.240
<v Speaker 4>He's my only options?

0:19:22.800 --> 0:19:24.920
<v Speaker 3>Why why is this happening?

0:19:25.160 --> 0:19:27.000
<v Speaker 2>So I think this is the tricky part, right, This

0:19:27.040 --> 0:19:29.240
<v Speaker 2>feels like a catch twenty two t T Yeah, because

0:19:29.440 --> 0:19:32.560
<v Speaker 2>on one hand, we have birth control that you're taking

0:19:32.800 --> 0:19:36.199
<v Speaker 2>to alleviate certain symptoms and feelings that you have, so

0:19:36.640 --> 0:19:39.800
<v Speaker 2>migrains or changes in period mood.

0:19:40.160 --> 0:19:40.560
<v Speaker 3>Yeah.

0:19:40.600 --> 0:19:42.680
<v Speaker 4>But on the other hand, if you don't have.

0:19:42.640 --> 0:19:44.760
<v Speaker 2>The right combination of birth control, or if the birth

0:19:44.800 --> 0:19:47.360
<v Speaker 2>control you have isn't right for you, you can then

0:19:47.480 --> 0:19:49.000
<v Speaker 2>get these exact same.

0:19:49.000 --> 0:19:51.000
<v Speaker 3>Side effects from the birth control.

0:19:51.160 --> 0:19:53.800
<v Speaker 2>Yes, it's like a mixed bag, like hmm, maybe it's

0:19:53.840 --> 0:19:55.080
<v Speaker 2>a treat, maybe it's a trick.

0:19:55.400 --> 0:19:58.560
<v Speaker 1>I don't know, honestly. In twenty fourteen, Mark and Call,

0:19:58.800 --> 0:20:02.280
<v Speaker 1>the company behind the new which is a hormonal form.

0:20:02.119 --> 0:20:02.880
<v Speaker 3>Of birth control.

0:20:03.000 --> 0:20:06.359
<v Speaker 1>They settled at a court for one hundred million dollars

0:20:06.400 --> 0:20:10.600
<v Speaker 1>after facing thousands of lawsuits alleging injury and death from

0:20:10.640 --> 0:20:13.800
<v Speaker 1>serious side effects like blood clots, strokes, and heart attacks

0:20:13.800 --> 0:20:15.840
<v Speaker 1>from folks that were using maneuvering.

0:20:16.000 --> 0:20:19.480
<v Speaker 2>And that's the part that makes it really terrible. Right overall,

0:20:19.720 --> 0:20:22.200
<v Speaker 2>you think of birth control as this thing that gives

0:20:22.200 --> 0:20:26.760
<v Speaker 2>you more agency and control over your body and your health, right,

0:20:26.840 --> 0:20:30.320
<v Speaker 2>but then it's coming along with these really serious side effects,

0:20:30.400 --> 0:20:33.240
<v Speaker 2>and some of them, like we said, are not just

0:20:33.440 --> 0:20:36.360
<v Speaker 2>one off, right, these are long term side effects.

0:20:36.600 --> 0:20:40.200
<v Speaker 6>So that's where I think we really could use improvements

0:20:40.280 --> 0:20:43.359
<v Speaker 6>and just take this big data approach that we're taking

0:20:43.400 --> 0:20:47.080
<v Speaker 6>to try to understand, Okay, this group of people were

0:20:47.119 --> 0:20:50.080
<v Speaker 6>on the same birth control, half of them felt great

0:20:50.119 --> 0:20:53.200
<v Speaker 6>and half of them felt miserable. What is different about

0:20:53.200 --> 0:20:56.199
<v Speaker 6>their underlying biology? And can we save that group of

0:20:56.200 --> 0:20:59.160
<v Speaker 6>people who felt miserable from going on the wrong one

0:20:59.200 --> 0:20:59.919
<v Speaker 6>in the first place.

0:21:00.160 --> 0:21:03.080
<v Speaker 1>So that really makes me think, like, why is it

0:21:03.240 --> 0:21:06.840
<v Speaker 1>so complicated? It seems like drug companies and healthcare providers

0:21:06.920 --> 0:21:08.920
<v Speaker 1>could be doing a better job with this? Is there

0:21:09.000 --> 0:21:11.800
<v Speaker 1>funding going into R and D for better birth control?

0:21:12.080 --> 0:21:14.200
<v Speaker 6>This is a stat I heard recently that blew my mind.

0:21:14.280 --> 0:21:17.760
<v Speaker 6>So a typical drug, fifty percent of the profits from

0:21:17.800 --> 0:21:20.359
<v Speaker 6>that go back into R and D for improving that drug, right,

0:21:20.400 --> 0:21:21.640
<v Speaker 6>because you can always.

0:21:21.400 --> 0:21:24.600
<v Speaker 5>Lower that blood pressure a little bit more. Birth control

0:21:25.600 --> 0:21:28.600
<v Speaker 5>two percent goes back to R and D two percent.

0:21:28.720 --> 0:21:30.440
<v Speaker 2>Now, why are we getting the short end as the stick.

0:21:30.680 --> 0:21:34.479
<v Speaker 3>I can think of one very large reason.

0:21:34.840 --> 0:21:36.960
<v Speaker 2>I feel like just because the method is effective at

0:21:37.000 --> 0:21:39.800
<v Speaker 2>preventing pregnancy, like, that's not it. We still can work

0:21:39.800 --> 0:21:41.679
<v Speaker 2>on some of these other things over here. We just

0:21:41.800 --> 0:21:44.240
<v Speaker 2>rattled that list off very fast on the commercial.

0:21:44.680 --> 0:21:46.679
<v Speaker 1>For real, And I mean that's what's being done with

0:21:46.880 --> 0:21:49.720
<v Speaker 1>other drugs. Like Elizabeth was saying, when you think about

0:21:49.880 --> 0:21:54.200
<v Speaker 1>blood pressure medication and all these different types of drugs,

0:21:54.280 --> 0:21:56.480
<v Speaker 1>I feel like they're constantly getting better. They're always trying

0:21:56.480 --> 0:21:58.320
<v Speaker 1>to make sure that your blood pressure is going to

0:21:58.359 --> 0:22:01.320
<v Speaker 1>get even lower, even lower with each iteration. But it

0:22:01.320 --> 0:22:03.240
<v Speaker 1>doesn't seem like the same type of energy is being

0:22:03.240 --> 0:22:04.159
<v Speaker 1>brought to birth control.

0:22:04.520 --> 0:22:04.720
<v Speaker 3>Right.

0:22:04.920 --> 0:22:08.040
<v Speaker 2>And like Elizabeth said, if people are getting off of

0:22:08.080 --> 0:22:10.399
<v Speaker 2>birth control because of the side effects, that means the

0:22:10.400 --> 0:22:13.000
<v Speaker 2>birth control isn't effective because they're not taking it right.

0:22:13.000 --> 0:22:14.440
<v Speaker 4>That's introducing more gaps.

0:22:14.520 --> 0:22:16.880
<v Speaker 3>Come on, folks, what's not clicking Steven?

0:22:20.880 --> 0:22:23.400
<v Speaker 2>And we said at the top, where's the disruption? This

0:22:23.440 --> 0:22:25.679
<v Speaker 2>is your mama's birth control? Like this feels like the

0:22:25.720 --> 0:22:29.320
<v Speaker 2>same birth control over and over. Where's a new birth control?

0:22:29.520 --> 0:22:31.199
<v Speaker 3>Right? We got retro birth control.

0:22:31.440 --> 0:22:35.840
<v Speaker 6>Yes, there are people trying to work on male contraceptives.

0:22:35.880 --> 0:22:38.560
<v Speaker 5>For example, some of those clinical trials.

0:22:38.200 --> 0:22:41.800
<v Speaker 6>Were stopped pretty early because men were complaining of waking,

0:22:42.080 --> 0:22:46.000
<v Speaker 6>acne and mood changes, So imagine that. Unfortunately, it looks

0:22:46.040 --> 0:22:47.720
<v Speaker 6>like a lot of the other things where if you

0:22:47.800 --> 0:22:51.800
<v Speaker 6>look at you know, prostate cancer versus breast cancer research dollars,

0:22:52.160 --> 0:22:55.159
<v Speaker 6>turns out sexism and it's reflected in all aspects of

0:22:55.200 --> 0:22:56.840
<v Speaker 6>our government and budgets.

0:22:57.080 --> 0:22:58.919
<v Speaker 1>It's just wild to me that men are complaining of

0:22:58.920 --> 0:23:03.200
<v Speaker 1>these side effects, you know, gain mood changes, acne, when

0:23:03.200 --> 0:23:05.840
<v Speaker 1>these are the exact same side effects that everybody else

0:23:05.880 --> 0:23:07.560
<v Speaker 1>has been dealing with taking birth control.

0:23:07.720 --> 0:23:09.560
<v Speaker 4>Right, It's like, oh, you don't like that, neither do I?

0:23:10.320 --> 0:23:12.520
<v Speaker 1>You know, Like, have you seen the TikTok where the

0:23:12.800 --> 0:23:16.240
<v Speaker 1>girlfriends are showing the birth control pamphlet? Yes, their partners

0:23:16.240 --> 0:23:18.480
<v Speaker 1>are reading through the birth control and they're like, what

0:23:18.520 --> 0:23:18.919
<v Speaker 1>the heck.

0:23:18.880 --> 0:23:19.520
<v Speaker 3>Is all this stuff?

0:23:19.560 --> 0:23:20.280
<v Speaker 4>They are shocked.

0:23:20.359 --> 0:23:23.359
<v Speaker 2>They cannot believe how many side effects come along with

0:23:23.480 --> 0:23:24.360
<v Speaker 2>taking birth control.

0:23:24.480 --> 0:23:26.520
<v Speaker 1>If you've seen a birth control pamphlet, you know that

0:23:26.760 --> 0:23:30.320
<v Speaker 1>it is the size of a city block and the

0:23:30.440 --> 0:23:34.399
<v Speaker 1>type is very, very tiny, and it has all of

0:23:34.440 --> 0:23:37.080
<v Speaker 1>the chemicals, how to take the birth control, all of

0:23:37.119 --> 0:23:40.280
<v Speaker 1>the side effects, and everyone's blown away. And then the

0:23:40.320 --> 0:23:43.160
<v Speaker 1>men they're complaining about these things, and I'm just like, wow,

0:23:43.280 --> 0:23:44.679
<v Speaker 1>but it's okay for.

0:23:44.640 --> 0:23:47.480
<v Speaker 3>Us to go through all of that. Hmm. That's that's

0:23:47.600 --> 0:23:48.200
<v Speaker 3>very interesting.

0:23:48.359 --> 0:23:48.720
<v Speaker 4>Mm hmm.

0:23:49.280 --> 0:23:51.040
<v Speaker 1>Let's take a break and when we come back, we're

0:23:51.080 --> 0:23:54.240
<v Speaker 1>gonna talk all about how Elizabeth and her company Aiden

0:23:54.440 --> 0:23:56.399
<v Speaker 1>are shaping the future of birth control.

0:24:15.800 --> 0:24:18.400
<v Speaker 2>We're back, and before we dive back into our dissection

0:24:18.440 --> 0:24:20.600
<v Speaker 2>with doctor Elizabeth Russeau, what are we going to be

0:24:20.640 --> 0:24:22.080
<v Speaker 2>dissecting next week?

0:24:22.240 --> 0:24:25.560
<v Speaker 1>Next week, we're talking about HIV. It's been around for decades,

0:24:25.600 --> 0:24:29.520
<v Speaker 1>but recently there's been huge strides in developing an HIV vaccine,

0:24:29.560 --> 0:24:32.399
<v Speaker 1>and we're gonna get into it with doctor Christine Daniels.

0:24:32.520 --> 0:24:35.240
<v Speaker 2>Also, starting next week, Dope Labs is going to be

0:24:35.359 --> 0:24:38.160
<v Speaker 2>exclusive to Spotify, So if you're listening to us from

0:24:38.200 --> 0:24:41.000
<v Speaker 2>somewhere else, go ahead and sign up for free on

0:24:41.080 --> 0:24:43.880
<v Speaker 2>Spotify and follow us there so you can make sure

0:24:43.920 --> 0:24:47.000
<v Speaker 2>you catch next week's episode plus all the other stuff

0:24:47.000 --> 0:24:48.560
<v Speaker 2>we have in the pipeline this semester.

0:24:48.720 --> 0:24:50.399
<v Speaker 3>You don't want to miss it. So what are you

0:24:50.400 --> 0:24:52.080
<v Speaker 3>waiting for? Just do it? Just do it.

0:24:52.960 --> 0:24:55.080
<v Speaker 2>Let's get back to today's lab. So we're talking to

0:24:55.119 --> 0:24:57.560
<v Speaker 2>doctor Russeau, and this is all about birth control. In

0:24:57.600 --> 0:25:00.000
<v Speaker 2>the first half of the dissection, we focused on what's

0:25:00.160 --> 0:25:03.360
<v Speaker 2>not working with current birth control methods. Sure, if taken correctly,

0:25:03.400 --> 0:25:06.560
<v Speaker 2>they can be effective at preventing unwanted pregnancy, but they

0:25:06.640 --> 0:25:10.280
<v Speaker 2>also introduce a host of unwanted side effects to the patients.

0:25:10.440 --> 0:25:12.720
<v Speaker 2>Many patients have to go through a cycle of trial

0:25:12.760 --> 0:25:15.679
<v Speaker 2>and error, leading to a really frustrating experience trying to

0:25:15.720 --> 0:25:18.359
<v Speaker 2>find a birth control that works for their bodies. The

0:25:18.400 --> 0:25:21.480
<v Speaker 2>average person tries four different birth control methods before finding

0:25:21.520 --> 0:25:24.320
<v Speaker 2>one that actually works. And that feels like a terrible

0:25:24.320 --> 0:25:26.560
<v Speaker 2>shooting rate for a product that's been on the market

0:25:26.600 --> 0:25:28.680
<v Speaker 2>since nineteen sixties, and.

0:25:28.640 --> 0:25:31.439
<v Speaker 1>For medication that is as old as my parents. At

0:25:31.560 --> 0:25:33.280
<v Speaker 1>least they should be doing way better than that.

0:25:38.280 --> 0:25:41.080
<v Speaker 2>In twenty nineteen, Elizabeth founded Aiden, a company on a

0:25:41.160 --> 0:25:44.639
<v Speaker 2>quest to revolutionize how birth control is evaluated and prescribed.

0:25:44.800 --> 0:25:49.280
<v Speaker 6>People have very passionate opinions around birth control, right. They

0:25:49.359 --> 0:25:52.000
<v Speaker 6>either think it's great and they need it and they're

0:25:52.040 --> 0:25:54.480
<v Speaker 6>so glad we're trying to solve something that hasn't been

0:25:54.920 --> 0:25:58.640
<v Speaker 6>addressed before, or they've had a bad experience, or they're

0:25:58.640 --> 0:26:01.600
<v Speaker 6>in that unfortunate category of struggling with fertility and they're

0:26:01.640 --> 0:26:05.120
<v Speaker 6>really angry and they're like, my birth control is the devil, right,

0:26:05.320 --> 0:26:07.679
<v Speaker 6>And so I get it. I mean, I wouldn't have,

0:26:08.160 --> 0:26:10.560
<v Speaker 6>you know, switched my academic career to work on this

0:26:10.600 --> 0:26:13.600
<v Speaker 6>if I wasn't also passionate about realizing that we need

0:26:13.640 --> 0:26:14.240
<v Speaker 6>a better.

0:26:14.119 --> 0:26:14.880
<v Speaker 5>Standard of care.

0:26:15.119 --> 0:26:19.879
<v Speaker 1>Aiden uses an approach that's called precision or personalized medicine.

0:26:19.920 --> 0:26:23.359
<v Speaker 1>So our first question about Aiden is what is precision medicine?

0:26:23.400 --> 0:26:27.160
<v Speaker 6>Precision medicine or personalized medicine at its most basic level,

0:26:27.440 --> 0:26:30.320
<v Speaker 6>is just accepting something that I think we all know,

0:26:30.440 --> 0:26:32.680
<v Speaker 6>which is that one size does not fit all.

0:26:32.840 --> 0:26:34.879
<v Speaker 5>Right. We are complicated, we are different.

0:26:34.920 --> 0:26:37.280
<v Speaker 6>Why would you think our insights would respond the same

0:26:37.320 --> 0:26:38.159
<v Speaker 6>to different drugs?

0:26:38.400 --> 0:26:38.880
<v Speaker 3>Exactly?

0:26:39.119 --> 0:26:42.240
<v Speaker 1>Different medication affects people differently, and it shouldn't be one

0:26:42.280 --> 0:26:43.000
<v Speaker 1>size fits all.

0:26:43.240 --> 0:26:47.040
<v Speaker 2>So understanding what AIDEN is designed to do, how does

0:26:47.080 --> 0:26:48.760
<v Speaker 2>it work, what does it look like? What is the

0:26:48.800 --> 0:26:53.000
<v Speaker 2>ideal AIDEN workflow that would lead to better birth control experiences?

0:26:53.240 --> 0:26:55.520
<v Speaker 6>How it works is you get a test kit sent

0:26:55.560 --> 0:26:58.359
<v Speaker 6>to your home and you spit into a tube for

0:26:58.600 --> 0:27:01.879
<v Speaker 6>saliva that we used to extract your DNA, and you

0:27:01.920 --> 0:27:04.719
<v Speaker 6>also provide a drop of blood from your finger that

0:27:04.760 --> 0:27:07.520
<v Speaker 6>we use to analyze the hormone levels of these six

0:27:07.560 --> 0:27:08.440
<v Speaker 6>different hormones.

0:27:08.600 --> 0:27:11.120
<v Speaker 1>Doctor Ruzo gave us two examples about how the data

0:27:11.160 --> 0:27:13.800
<v Speaker 1>collected from the kits will improve health outcomes for people

0:27:13.800 --> 0:27:14.880
<v Speaker 1>who use birth control.

0:27:15.080 --> 0:27:18.359
<v Speaker 6>The first is that we're looking at genetic risk for

0:27:18.600 --> 0:27:21.760
<v Speaker 6>experiencing blood clot. So there are a couple of well

0:27:21.800 --> 0:27:24.680
<v Speaker 6>known sites in the genome that, if you have them,

0:27:24.800 --> 0:27:28.560
<v Speaker 6>increase your risk for experiencing blood clot five to twelve fold,

0:27:28.640 --> 0:27:31.040
<v Speaker 6>depending on which site you're looking at. But if you

0:27:31.119 --> 0:27:34.000
<v Speaker 6>happen to have one of those genetic markers and you're

0:27:34.040 --> 0:27:36.480
<v Speaker 6>on a birth control that's known to increase your propensity

0:27:36.480 --> 0:27:39.520
<v Speaker 6>for experiencing blood clot, that risk goes up to like thirtyfold,

0:27:39.760 --> 0:27:42.920
<v Speaker 6>So it's a really massive risk and it's not currently

0:27:43.000 --> 0:27:44.360
<v Speaker 6>checked in the standard of care.

0:27:44.560 --> 0:27:47.480
<v Speaker 2>That's a huge risk, and quite frankly, I'm shocked that

0:27:47.640 --> 0:27:48.600
<v Speaker 2>they're not checking for this.

0:27:48.800 --> 0:27:50.399
<v Speaker 3>Honestly, why isn't this part of it.

0:27:50.440 --> 0:27:52.640
<v Speaker 1>If I have to go to the doctor to get

0:27:52.680 --> 0:27:56.120
<v Speaker 1>a prescription to get the birth control, why are they

0:27:56.160 --> 0:27:58.320
<v Speaker 1>doing this to figure out if I'm at risk for

0:27:58.359 --> 0:27:59.119
<v Speaker 1>any of these things.

0:27:59.160 --> 0:28:02.400
<v Speaker 2>It just seems like it should be pretty natural, right.

0:28:02.640 --> 0:28:05.800
<v Speaker 2>Doctor Riso gives us another example. The second example looks

0:28:05.800 --> 0:28:07.399
<v Speaker 2>at risk for depression.

0:28:07.000 --> 0:28:09.920
<v Speaker 6>Which, as you probably all know, is a complex disease,

0:28:10.040 --> 0:28:12.359
<v Speaker 6>meaning it's not just about a single site in the

0:28:12.400 --> 0:28:15.119
<v Speaker 6>genome or just about your genetics. It can also be

0:28:15.160 --> 0:28:17.720
<v Speaker 6>about environment. But there's been a lot of great work

0:28:17.800 --> 0:28:21.239
<v Speaker 6>done in the genetics of depression. So we've used a

0:28:21.280 --> 0:28:24.000
<v Speaker 6>new technique called polygenic risk score, which you can think

0:28:24.000 --> 0:28:28.000
<v Speaker 6>of as basically a cumulative risk for experiencing depression, and

0:28:28.040 --> 0:28:30.560
<v Speaker 6>we're using that to try to help people who are

0:28:30.720 --> 0:28:34.160
<v Speaker 6>at a high risk for depression to not further exacerbate

0:28:34.200 --> 0:28:37.000
<v Speaker 6>that by adding a drug, specifically a birth control drug

0:28:37.040 --> 0:28:40.480
<v Speaker 6>that's also known to increase the likelihood of experiencing depression.

0:28:40.640 --> 0:28:43.080
<v Speaker 1>Could you imagine if everyone could have a personalized birth

0:28:43.080 --> 0:28:46.720
<v Speaker 1>control method that was safe and effective without the risk

0:28:46.760 --> 0:28:49.800
<v Speaker 1>of side effects, without that trial and error process.

0:28:49.480 --> 0:28:52.520
<v Speaker 4>That would be ideal. That would be ideal.

0:28:52.720 --> 0:28:57.280
<v Speaker 6>I mean, honestly, our mission is really to make scientific

0:28:57.320 --> 0:29:01.640
<v Speaker 6>discovery more inclusive and to be the world's most patient

0:29:01.720 --> 0:29:05.480
<v Speaker 6>centric precision medicine company. So even though we're starting with

0:29:05.560 --> 0:29:09.320
<v Speaker 6>birth control, I really see us as doing precision medicine

0:29:09.560 --> 0:29:13.280
<v Speaker 6>in an area that hasn't been well studied before, which

0:29:13.320 --> 0:29:18.160
<v Speaker 6>is endrochronology plus genetics. So what we're doing with our

0:29:18.360 --> 0:29:21.400
<v Speaker 6>first product, which is the birth Control Test, is we

0:29:21.680 --> 0:29:25.760
<v Speaker 6>are looking at both your genetic predisposition as well as

0:29:25.760 --> 0:29:30.120
<v Speaker 6>your hormone levels, together with self reported information on your

0:29:30.160 --> 0:29:32.680
<v Speaker 6>own medical history and preferences.

0:29:32.880 --> 0:29:35.400
<v Speaker 2>ADA analyses six hundred thousand sites in the genome and

0:29:35.520 --> 0:29:38.200
<v Speaker 2>six different hormone levels to find the best birth control.

0:29:38.360 --> 0:29:41.560
<v Speaker 1>By adding hormone analysis to this process, AIDEN is able

0:29:41.600 --> 0:29:44.240
<v Speaker 1>to get a more precise picture of someone's medical chart

0:29:44.280 --> 0:29:47.520
<v Speaker 1>and predisposition to certain side effects. They're also able to

0:29:47.560 --> 0:29:49.880
<v Speaker 1>continue analyzing hormone levels over.

0:29:49.760 --> 0:29:52.800
<v Speaker 6>Time because we know that these hormones change, not just

0:29:52.880 --> 0:29:56.520
<v Speaker 6>throughout the course of a cycling month, but throughout somebody's lifetime,

0:29:56.680 --> 0:30:00.760
<v Speaker 6>as you move from puberty to menopause, they look quite different.

0:30:00.960 --> 0:30:03.320
<v Speaker 6>And we also know that there are sort of these

0:30:03.360 --> 0:30:06.920
<v Speaker 6>broad reference ranges that don't take into account things like

0:30:07.480 --> 0:30:11.120
<v Speaker 6>weight and age and ethnicity that we all know play

0:30:11.240 --> 0:30:13.120
<v Speaker 6>into what somebody's.

0:30:12.760 --> 0:30:13.920
<v Speaker 5>Quote unquote normal is.

0:30:14.000 --> 0:30:17.520
<v Speaker 6>So our goal is to help make those more personalized

0:30:17.680 --> 0:30:20.040
<v Speaker 6>in a way that would also unlock our ability to

0:30:20.160 --> 0:30:24.360
<v Speaker 6>be predictive about what somebody's disease state might look like.

0:30:24.640 --> 0:30:27.600
<v Speaker 2>The other mission for AIDEN is just broadening the research

0:30:27.640 --> 0:30:30.240
<v Speaker 2>that's currently available when it comes to birth control, which

0:30:30.280 --> 0:30:32.800
<v Speaker 2>up until now has been underfunded, which we talked about

0:30:32.800 --> 0:30:35.240
<v Speaker 2>a little bit earlier, and is just generally lacking.

0:30:35.400 --> 0:30:38.000
<v Speaker 6>And to your question about you know, what's the data

0:30:38.000 --> 0:30:41.640
<v Speaker 6>that's out there, what does it look like, it is lacking.

0:30:41.920 --> 0:30:43.640
<v Speaker 5>It is severely lacking.

0:30:43.920 --> 0:30:46.560
<v Speaker 6>So a lot of our preliminary data, you know, we

0:30:46.640 --> 0:30:49.479
<v Speaker 6>are standing on the shoulders of other scientists who have

0:30:49.520 --> 0:30:52.360
<v Speaker 6>cared to focus on this, who have done work to show,

0:30:52.480 --> 0:30:54.760
<v Speaker 6>for example, that certain kinds of birth control are more

0:30:54.800 --> 0:30:58.800
<v Speaker 6>associated with depression, and that certain kinds of birth control

0:30:58.840 --> 0:31:01.840
<v Speaker 6>increase propensity for blood clots. Things like that. When we

0:31:01.880 --> 0:31:03.760
<v Speaker 6>went to start a lot of the preliminary data was

0:31:03.800 --> 0:31:07.120
<v Speaker 6>me like mining databases that were out there and trying

0:31:07.120 --> 0:31:08.960
<v Speaker 6>to clean it up to make sense of like what

0:31:09.120 --> 0:31:09.680
<v Speaker 6>do we know?

0:31:09.840 --> 0:31:11.480
<v Speaker 5>What are the patterns that we see?

0:31:11.640 --> 0:31:14.720
<v Speaker 1>And that also means including everyone in the research, including

0:31:14.800 --> 0:31:16.760
<v Speaker 1>women and people of color.

0:31:16.960 --> 0:31:19.000
<v Speaker 6>I think as of twenty eighteen, it was something like

0:31:19.040 --> 0:31:22.280
<v Speaker 6>eighty percent of genome wide association studies were done only

0:31:22.280 --> 0:31:25.800
<v Speaker 6>on individuals of European descent, which just limits our power

0:31:25.880 --> 0:31:27.800
<v Speaker 6>to understand the biology in everyone.

0:31:27.840 --> 0:31:30.360
<v Speaker 5>We're hurting everyone by the way that we're approaching this.

0:31:30.560 --> 0:31:33.400
<v Speaker 6>So I think part of our mission is, like I said,

0:31:33.400 --> 0:31:36.000
<v Speaker 6>to make scientific discovery more inclusive. And that's not just

0:31:36.040 --> 0:31:39.000
<v Speaker 6>about paying attention to women, although we really need to

0:31:39.040 --> 0:31:41.440
<v Speaker 6>do that because women weren't required to be included in

0:31:41.440 --> 0:31:46.120
<v Speaker 6>clinical trials until nineteen ninety three, which has led to

0:31:46.240 --> 0:31:49.560
<v Speaker 6>this massive medical research gender gap. But it's also about

0:31:49.560 --> 0:31:53.080
<v Speaker 6>making sure that we have diverse representation in the samples

0:31:53.080 --> 0:31:56.280
<v Speaker 6>that are there to continue to make discoveries that actually

0:31:56.320 --> 0:31:57.280
<v Speaker 6>benefit everyone.

0:31:57.560 --> 0:32:01.760
<v Speaker 1>Women weren't required to be in clinical trials until nineteen

0:32:02.000 --> 0:32:03.000
<v Speaker 1>ninety three.

0:32:03.040 --> 0:32:04.080
<v Speaker 4>That's very recent.

0:32:04.480 --> 0:32:07.320
<v Speaker 1>What that means is that you could have whole trials

0:32:07.320 --> 0:32:10.200
<v Speaker 1>go through and the people that are doing the research

0:32:10.360 --> 0:32:13.560
<v Speaker 1>know the effects that it has on men, but they

0:32:13.560 --> 0:32:16.160
<v Speaker 1>don't know the effects that it has on women, and

0:32:16.160 --> 0:32:18.400
<v Speaker 1>then they end up being prescribed to everybody, so then

0:32:18.640 --> 0:32:21.480
<v Speaker 1>it could possibly be negatively affecting women and they have

0:32:21.520 --> 0:32:22.080
<v Speaker 1>no idea.

0:32:22.320 --> 0:32:25.320
<v Speaker 2>Yeah, Doctor Russell mentioned that birth control is really just

0:32:25.360 --> 0:32:27.880
<v Speaker 2>the first step for Aiden. We wanted to know, wes Nix,

0:32:27.960 --> 0:32:29.560
<v Speaker 2>what does the future of Aiden look like?

0:32:29.920 --> 0:32:33.800
<v Speaker 6>The short term step is for birth control. We get

0:32:33.920 --> 0:32:37.440
<v Speaker 6>more and more specific about how we can make recommendations.

0:32:37.440 --> 0:32:39.400
<v Speaker 6>So I'm not out here saying on day one for

0:32:39.480 --> 0:32:41.040
<v Speaker 6>every single person, I'm going to get you on the

0:32:41.120 --> 0:32:43.520
<v Speaker 6>right birth control of the first time, because we just

0:32:43.600 --> 0:32:45.760
<v Speaker 6>do not have that data. We're going to try our best,

0:32:45.880 --> 0:32:48.480
<v Speaker 6>but we're also going to learn as we go and

0:32:48.640 --> 0:32:52.200
<v Speaker 6>make our recommendations more and more specific. People go on

0:32:52.240 --> 0:32:55.320
<v Speaker 6>birth control, often in their teens to treat PMS or

0:32:55.400 --> 0:32:59.480
<v Speaker 6>PDD right like, they potentially could start their journey with

0:32:59.560 --> 0:33:03.240
<v Speaker 6>Aiden and stay with us to understand their hormones over time.

0:33:03.480 --> 0:33:06.520
<v Speaker 4>It feels like this was really illuminating.

0:33:06.720 --> 0:33:08.800
<v Speaker 2>You know, there are things that just get taken for

0:33:08.840 --> 0:33:11.120
<v Speaker 2>granted or that become the status quo and it's just like, ah,

0:33:11.400 --> 0:33:13.360
<v Speaker 2>just leave it like it is. And this is a

0:33:13.400 --> 0:33:16.360
<v Speaker 2>place where we don't need to leave it like it is. Yeah,

0:33:16.400 --> 0:33:17.200
<v Speaker 2>somebody needs shake the.

0:33:17.200 --> 0:33:19.560
<v Speaker 1>Table, honestly, and there's a lot of people doing a

0:33:19.560 --> 0:33:22.120
<v Speaker 1>lot of really important work to make sure that that happens,

0:33:22.200 --> 0:33:24.160
<v Speaker 1>and that the laws that are put in place are

0:33:24.200 --> 0:33:28.040
<v Speaker 1>put in place to give women more agency and more

0:33:28.080 --> 0:33:30.720
<v Speaker 1>freedom to make a choice with their own bodies. And

0:33:30.800 --> 0:33:33.560
<v Speaker 1>so when we do have that freedom, a company like

0:33:33.600 --> 0:33:37.120
<v Speaker 1>Aiden is giving us the ability to get those medications

0:33:37.240 --> 0:33:39.280
<v Speaker 1>and have it work to our benefit and not to

0:33:39.320 --> 0:33:42.320
<v Speaker 1>our detriment. In the background, another good point that Elizabeth

0:33:42.360 --> 0:33:46.600
<v Speaker 1>raised is our bodies changed over time. When you think

0:33:46.600 --> 0:33:49.800
<v Speaker 1>about how long folks are on birth control, birth control

0:33:49.840 --> 0:33:52.560
<v Speaker 1>that worked for you at age sixteen might not be

0:33:52.680 --> 0:33:55.960
<v Speaker 1>birth control for you at age thirty six or forty six.

0:33:56.120 --> 0:33:56.320
<v Speaker 5>You know.

0:33:56.600 --> 0:33:59.080
<v Speaker 1>Yeah, my body lotion that I was using at that

0:33:59.120 --> 0:34:03.440
<v Speaker 1>age would not It's changed. Okay, I need pure vasiline, Okay,

0:34:03.680 --> 0:34:06.920
<v Speaker 1>some mut tourize this crusty body. I can only imagine

0:34:06.960 --> 0:34:10.040
<v Speaker 1>what's going on on the inside.

0:34:13.880 --> 0:34:16.359
<v Speaker 2>I think something that's so important that Aiden is doing

0:34:16.520 --> 0:34:19.759
<v Speaker 2>is collecting stories from people, yes that made it really real,

0:34:19.840 --> 0:34:22.279
<v Speaker 2>and it made me think back on my own experiences.

0:34:23.080 --> 0:34:25.080
<v Speaker 2>How many things just get pushed under the rug or

0:34:25.080 --> 0:34:27.640
<v Speaker 2>dismissed because it's not the experience of the majority.

0:34:27.800 --> 0:34:30.440
<v Speaker 1>Yeah, and so with her collecting these stories, she might

0:34:30.480 --> 0:34:32.160
<v Speaker 1>even be able to shine the light on something that

0:34:32.320 --> 0:34:35.000
<v Speaker 1>might be a shared experience between a lot of different

0:34:35.000 --> 0:34:37.120
<v Speaker 1>women and they just had no idea it was linked

0:34:37.120 --> 0:34:39.920
<v Speaker 1>to their birth control. This type of research is definitely

0:34:40.000 --> 0:34:42.560
<v Speaker 1>going to improve the quality of life of so many.

0:34:42.320 --> 0:34:44.839
<v Speaker 5>People birth control odysseies, we're calling them.

0:34:44.920 --> 0:34:46.719
<v Speaker 6>So if you go to our website, you can go

0:34:46.840 --> 0:34:50.480
<v Speaker 6>to our stories and submit your own birth control odyssey

0:34:50.719 --> 0:34:55.400
<v Speaker 6>to help destigmatize, help people feel less alone in their experience.

0:34:55.480 --> 0:34:58.719
<v Speaker 6>I've learned so much from these stories. I'm blown away

0:34:58.840 --> 0:35:00.880
<v Speaker 6>by how no two story are the same.

0:35:04.600 --> 0:35:06.839
<v Speaker 3>All Right, it's time for our one thing. What's your

0:35:06.840 --> 0:35:07.839
<v Speaker 3>one thing this week? Ze?

0:35:07.960 --> 0:35:11.759
<v Speaker 2>My one thing this week is actually an app. It's

0:35:11.800 --> 0:35:16.400
<v Speaker 2>called to doist TODT. I found this app while reading

0:35:16.400 --> 0:35:19.680
<v Speaker 2>about digital productivity. Because if you're like me, you have

0:35:19.880 --> 0:35:22.960
<v Speaker 2>a notebook and maybe another smaller notebook and a series

0:35:23.040 --> 0:35:26.399
<v Speaker 2>of sticky notes and a calendar you're trying to keep

0:35:26.400 --> 0:35:29.359
<v Speaker 2>in emails and bookmarks and read it later and it

0:35:29.400 --> 0:35:30.960
<v Speaker 2>was too much stuff and so to do this is

0:35:30.960 --> 0:35:32.719
<v Speaker 2>a place where I can kind of consolidate all of

0:35:32.760 --> 0:35:35.400
<v Speaker 2>my things and keep my day on track.

0:35:35.600 --> 0:35:36.200
<v Speaker 3>I love that.

0:35:36.440 --> 0:35:40.359
<v Speaker 1>So my one thing is a food item, and it's

0:35:40.600 --> 0:35:44.960
<v Speaker 1>probably my favorite comfort food right now, and it's a

0:35:45.239 --> 0:35:48.200
<v Speaker 1>breakfast bagel from this place called Call your Mother. If

0:35:48.239 --> 0:35:51.200
<v Speaker 1>you live in the DC metro area, you all know

0:35:51.480 --> 0:35:54.000
<v Speaker 1>about it. You may not have been there, but if

0:35:54.040 --> 0:35:55.799
<v Speaker 1>you are in the area, or if you're planning on

0:35:55.960 --> 0:35:59.640
<v Speaker 1>being in the DC metro area, you should definitely look

0:35:59.719 --> 0:36:02.440
<v Speaker 1>for or Call your Mother location. I think they have

0:36:02.520 --> 0:36:05.000
<v Speaker 1>like four or five locations now. They just opened one

0:36:05.440 --> 0:36:08.400
<v Speaker 1>near my house and it is a gift and a curse.

0:36:08.480 --> 0:36:10.920
<v Speaker 1>My favorite thing to get there is the Sun City Bagel.

0:36:10.920 --> 0:36:16.160
<v Speaker 1>It's an everything bagel with cheese, eggs, bacon, and siracha

0:36:16.440 --> 0:36:20.480
<v Speaker 1>jam and it is perfection. It is a struggle for

0:36:20.520 --> 0:36:22.839
<v Speaker 1>me to not go there every single day.

0:36:27.560 --> 0:36:29.359
<v Speaker 2>That's it for Lab forty one. What did you think

0:36:29.400 --> 0:36:32.000
<v Speaker 2>about today's lab? Do you still have questions? Call us

0:36:32.040 --> 0:36:34.920
<v Speaker 2>at two zero two five six seven seven zero two

0:36:34.960 --> 0:36:36.759
<v Speaker 2>eight and tell us what you thought, or give us

0:36:36.760 --> 0:36:38.800
<v Speaker 2>an idea for another lab. We could do this semester.

0:36:39.040 --> 0:36:41.160
<v Speaker 2>We like to hear from you. That's two zero two

0:36:41.320 --> 0:36:43.480
<v Speaker 2>five six seven seven zero two eight.

0:36:43.360 --> 0:36:45.279
<v Speaker 1>And don't forget. There's so much more for you to

0:36:45.320 --> 0:36:48.000
<v Speaker 1>dig into. On our website. There'll be a cheat sheet

0:36:48.040 --> 0:36:52.200
<v Speaker 1>for today's lab, additional links and resources in the show notes. Plus,

0:36:52.280 --> 0:36:54.359
<v Speaker 1>you can sign up for our newsletter check it out

0:36:54.360 --> 0:36:58.840
<v Speaker 1>at Dope labspodcast dot com. Special thanks to today's guest expert,

0:36:58.960 --> 0:37:01.640
<v Speaker 1>doctor Elizabeth Russo, founder of Aiden.

0:37:01.840 --> 0:37:04.360
<v Speaker 2>You can follow her on Twitter at sequin Lab coaked.

0:37:04.480 --> 0:37:06.080
<v Speaker 2>If you want to sign up for early access to

0:37:06.080 --> 0:37:08.600
<v Speaker 2>Aiden's birth control tests, you can learn more about Aiden

0:37:08.680 --> 0:37:12.920
<v Speaker 2>science at Aiden dot com a d y n dot com.

0:37:13.040 --> 0:37:16.000
<v Speaker 1>Aiden is on Twitter and Instagram at Aiden Health. So

0:37:16.080 --> 0:37:19.920
<v Speaker 1>that's at a d y n h e a l

0:37:20.120 --> 0:37:26.799
<v Speaker 1>t h. Dope Labs is a Spotify original production from

0:37:26.880 --> 0:37:28.000
<v Speaker 1>Mega Own Media Group.

0:37:28.160 --> 0:37:32.360
<v Speaker 2>Our producers are Jenny Ratlitmast and Lydia Smith of WaveRunner Studios.

0:37:32.560 --> 0:37:35.880
<v Speaker 3>Editing in sound design by Rob Smerciak.

0:37:35.400 --> 0:37:37.000
<v Speaker 4>Mixing by Hannes Brown.

0:37:37.320 --> 0:37:41.160
<v Speaker 1>Original music composed and produced by Taka Yasuzawa and Alex

0:37:41.239 --> 0:37:42.600
<v Speaker 1>Sugier from Spotify.

0:37:42.719 --> 0:37:45.920
<v Speaker 2>Our executive producer is Gina Delvack and Creative producers are

0:37:45.920 --> 0:37:48.680
<v Speaker 2>Baron Farmer and Candace Manriquez Rinn.

0:37:48.640 --> 0:37:53.080
<v Speaker 1>Special thanks to Shirley ramos yasmin of Fife, camu Elolia,

0:37:53.520 --> 0:37:57.239
<v Speaker 1>Till krat Key and Brian Marquis. Executive producers from Mega

0:37:57.239 --> 0:37:59.680
<v Speaker 1>Own Media Group are Us T T Show, Dia and

0:37:59.760 --> 0:38:08.040
<v Speaker 1>zik Ll Watley. But sometimes you know what happens to me,

0:38:08.320 --> 0:38:11.200
<v Speaker 1>My brain switches up urethra and uterus.

0:38:10.760 --> 0:38:12.040
<v Speaker 4>And are not the same.

0:38:12.239 --> 0:38:13.760
<v Speaker 3>No, you pee out of you urethra.

0:38:14.160 --> 0:38:17.439
<v Speaker 4>Yeah, I know, not saying you know, I never can.

0:38:17.560 --> 0:38:19.640
<v Speaker 2>I'm like, I just pull a U word down when

0:38:19.640 --> 0:38:25.080
<v Speaker 2>I'm talking, just not umbrolla