WEBVTT - SYSK Selects: How Schizophrenia Works

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<v Speaker 1>Hi everyone, It's Josh here and for this week's s

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<v Speaker 1>Y s K Selects, I've chosen our episode on schizophrenia. UM.

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<v Speaker 1>First of all, please excuse the rampant use of the

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<v Speaker 1>word schizophrenic. We know better now, UM, and delight in

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<v Speaker 1>a clip of Wesley Willis's rock and roll McDonald's. If

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<v Speaker 1>you've never heard of Wesley Willis, co check him out, UM,

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<v Speaker 1>as I clearly want you to do throughout this episode.

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<v Speaker 1>And UM. Also note that there is a rare corrections

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<v Speaker 1>rather than listener mail correction segment that apparently just didn't

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<v Speaker 1>take off, probably because we would have just ended up

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<v Speaker 1>doing nothing but corrections for episodes at any rate. I

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<v Speaker 1>hope you enjoy this one. It's a good one. Welcome

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<v Speaker 1>to Stuff you should know from House Stuff Works dot com. Hey,

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<v Speaker 1>and welcome to the podcast. I'm Josh Clark with me

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<v Speaker 1>as always Charles W. Chucker's Chuck Chuck Tran Chuck a

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<v Speaker 1>luck Right? How you doing? I'm great. I'm going to

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<v Speaker 1>see Bob Dylan tonight. People are gonna be like, I

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<v Speaker 1>mean times, is Bob Dylan playing Atlanta? Have you ever

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<v Speaker 1>seen David Bowie? It's good I have not. Um, Yes,

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<v Speaker 1>you are, Chuck. I know you're very excited. I am.

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<v Speaker 1>I've seen him a few times, but it's always good.

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<v Speaker 1>Really yeah, too short though he buzzes through like fifteen songs.

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<v Speaker 1>He's out of there. Is he short? Oh? Well, he's

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<v Speaker 1>also short? But yea is he really? I was just kidding. No,

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<v Speaker 1>he's short. I guess those um Bell bottomed long pants

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<v Speaker 1>that he wore in the sixties on his album Like

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<v Speaker 1>Bottoms made him look kind of tall. Yeah. Um, alright,

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<v Speaker 1>so enough about Bob Dylan for the second time. I'm

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<v Speaker 1>not a big Dylan fan myself. It Um, let's talk

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<v Speaker 1>about schizophrenia instead. Okay. So I was looking for an

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<v Speaker 1>intro for this, and I mean there's plenty of stuff,

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<v Speaker 1>but it's all like pretty, you know, research heavy Astra

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<v Speaker 1>Zeneca was marketing Sarah quil off label and just settled. Um,

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<v Speaker 1>let's see what else Jared Lofner as being medicated against

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<v Speaker 1>as well. The guy who shot Gabrielle Gifford's Okay, really, yes,

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<v Speaker 1>he's he's been diagnosed as schizophrenic. Um. Finally uh and

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<v Speaker 1>then um, there was a homeless man in Los Angeles

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<v Speaker 1>who was beaten to death by the police yesterday or today. Um,

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<v Speaker 1>and all of this is kind of I realized like

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<v Speaker 1>there wasn't any one thing that I was like, well,

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<v Speaker 1>here's the intro. But I realized like all of it

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<v Speaker 1>together gives a pretty good overview of you know, schizophrenia

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<v Speaker 1>as it stands right now, which is it's misunderstood, it's

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<v Speaker 1>heavily prescribed, underfunded, and um. Yeah, and there's a lot

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<v Speaker 1>of people out there who aren't necessarily getting help who

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<v Speaker 1>need it. Yeah. In fact, I got a stat if

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<v Speaker 1>you want to go ahead and go there. You got

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<v Speaker 1>a bunch of stats you said for this, right I do. Um,

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<v Speaker 1>if you want to talk about people getting help and

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<v Speaker 1>and or needing help and not getting it. Uh, six

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<v Speaker 1>percent of six schizophrenics are homeless. Yeah, six percent are

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<v Speaker 1>in jail or prison, ten percent in nursing homes with

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<v Speaker 1>a family member or independently living supervise housing. So and

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<v Speaker 1>and it makes sense, Chuck to that these makes sense

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<v Speaker 1>because first of all, you have all of this crazy

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<v Speaker 1>stuff going on to you. That's your reality. So you're

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<v Speaker 1>having trouble dealing with reality as it stands. Um. It's secondly,

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<v Speaker 1>a lot of times schizophrenia comes on, Um, during times

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<v Speaker 1>when you learn how to hold down a job or

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<v Speaker 1>take care of yourself or do whatever. So you might

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<v Speaker 1>never learn how to do this because you're dealing with

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<v Speaker 1>your schizophrenia. Here's the shocking one. Okay, at any given moment,

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<v Speaker 1>there are more people with untreated severe psychiatric illnesses living

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<v Speaker 1>on the streets than there are receiving care. Well, they

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<v Speaker 1>outweigh that people that are actually getting help. That's that

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<v Speaker 1>is shocking, but not surprising. Somehow agreed. Wow, so you said,

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<v Speaker 1>what was that last one? Severe psychiatric illnesses? That's an

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<v Speaker 1>umbrella term. Obviously that schizophrenia falls in under that for sure,

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<v Speaker 1>But prior to the beginning of the twentieth century, it

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<v Speaker 1>was pretty much thought of as generalized illness, like the

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<v Speaker 1>mental illness was mental illness, and maybe there is a symptom,

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<v Speaker 1>your symptoms were different, but really you're mentally ill, which

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<v Speaker 1>was a huge step up from the spirit possession that

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<v Speaker 1>had you know, it had previously been ascribed to or

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<v Speaker 1>millions of years. Yeah, um, so it was. It's a

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<v Speaker 1>fairly recently classified mental illness. It wasn't until that. Um.

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<v Speaker 1>A German psychiatrist name Emil Crapelin classified schizophrenia as a

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<v Speaker 1>mental illness, and uh, he missed classified it as a

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<v Speaker 1>form of dementia early and early type of dementia. And

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<v Speaker 1>then in nineteen eleven a Swiss psychiatrist named Yugen Bleuler

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<v Speaker 1>came up with the name schizophrenia. That's right, Josh, and

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<v Speaker 1>he uh got that word from the Greek words for

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<v Speaker 1>split and mind, which contribute somewhat to the misconception that

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<v Speaker 1>it is a split personality disorder. But what he meant

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<v Speaker 1>was there's a disconnect with reality, right, the mind splits

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<v Speaker 1>from reality, which today we still that's how you still

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<v Speaker 1>perceive um schizophrenia, but rather than split, we use the

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<v Speaker 1>word break. There's a psychotic break. Yeah, and we should

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<v Speaker 1>go ahead and just uh, since that is a common misconception,

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<v Speaker 1>it is entirely different than split personality disorder, which they

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<v Speaker 1>call disassociative identity disorder. Now, and if you know the

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<v Speaker 1>movie the show United States of Terra, have you seen that? No,

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<v Speaker 1>I know what you're talking about though, with Tony let

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<v Speaker 1>she is has split personality disorder on that show. And

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<v Speaker 1>that's the one that you've always seen in the movies

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<v Speaker 1>where you have multiple personalities and they don't know about

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<v Speaker 1>each other, and one dominates the other. And uh, and

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<v Speaker 1>then what all about Eve was about? I never saw

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<v Speaker 1>that sybil civil Yeah for sure, but it's not schizophrenia.

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<v Speaker 1>That they have done nothing to do with each other

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<v Speaker 1>other than they're both types of mental illness, and um,

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<v Speaker 1>Hollywood is fascinated by them, that's right. Um. So yeah, well,

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<v Speaker 1>and that's that's a pretty good example, like of medicines

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<v Speaker 1>is starting to get ahold of what schizophrenia is, what

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<v Speaker 1>mental illnesses you know, in general, and then the public

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<v Speaker 1>at large still just being completely under educated about it. Um,

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<v Speaker 1>so let's educate people about it. Yeah. I want to

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<v Speaker 1>say too that this is like a lot of conditions

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<v Speaker 1>UM and disorders that developed later in life. To me,

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<v Speaker 1>that's this one of the ski areous things that can happen,

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<v Speaker 1>like your cruising along at years old and you think,

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<v Speaker 1>like you know, I'm all good, and you can develop

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<v Speaker 1>schizophrenia like a boom in a matter of weeks. Sometimes. Yeah,

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<v Speaker 1>it can either come on gradually or very suddenly in

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<v Speaker 1>an acute manner. Um And like you said, later in

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<v Speaker 1>life with men, schizophrenia usually develops UM in the late

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<v Speaker 1>teens or early twenties is when it starts UM or

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<v Speaker 1>in women, it's the mid twenties or the early thirties.

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<v Speaker 1>So yeah, by the time, by the time I was thirty,

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<v Speaker 1>I certainly didn't think I was going to become mentally ill. No,

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<v Speaker 1>you thought, I know my demons. You can write them

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<v Speaker 1>down in a list. I can quit them anytime I want.

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<v Speaker 1>And that's what they are, their self imposed demons, right,

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<v Speaker 1>this this is it wasn't something that was beyond my

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<v Speaker 1>control that happened to my mind. And yeah, that's how

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<v Speaker 1>schizophrenia hit you hit you later in life, and it

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<v Speaker 1>can happen all at once or gradually. And this is

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<v Speaker 1>not to scare the crap out of you if you're

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<v Speaker 1>in your teens or twenties, because there's only about a

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<v Speaker 1>one percent chance schizophrenia. It depends if if you're part

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<v Speaker 1>of the general population, there's a one percent chance. But

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<v Speaker 1>as we'll see that there are risk factors that increase

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<v Speaker 1>your chances of having schizophrenia. And no, we're not trying

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<v Speaker 1>to scare you. But then I guess kind of the

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<v Speaker 1>newest forms of treatment or newest thoughts about treating schizophrenia

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<v Speaker 1>is to make people aware of it, uh so that

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<v Speaker 1>they will be able to recognize it early on, and

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<v Speaker 1>apparently early treatment leads to a better success rate. I

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<v Speaker 1>think we'll talk about that across the board. But chuck, um,

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<v Speaker 1>there's two kinds of symptoms of schizophrenia and they're positive

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<v Speaker 1>and negative. And it's not like positive symptom means you

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<v Speaker 1>hallucinate bunnies, where negative symptom means you hallucinate like a

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<v Speaker 1>hell demon. Instead, positive symptom is like an exaggeration of

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<v Speaker 1>normal behavior. So like I see you, I hear things,

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<v Speaker 1>but I don't see you with horns, and I don't

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<v Speaker 1>hear Kermit here talking to me. Right, Um, So a

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<v Speaker 1>positive symptom is an exaggerated behavior. Negative symptom is the

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<v Speaker 1>absence of normal behavior, like you lack affect or the

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<v Speaker 1>ability to experience any emotion um or you you basically

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<v Speaker 1>are just generally apathetic, right and so it so those

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<v Speaker 1>are that's positive symptoms and negative symptoms. Yes, and uh,

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<v Speaker 1>certain negative symptoms are cognitive that deal a lot with

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<v Speaker 1>attention span and memory. Um, lack of memory an ability

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<v Speaker 1>to like plan anything or organize anything. Right. And then

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<v Speaker 1>another form of negative I should say, is called evolition. Um.

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<v Speaker 1>It's basically I think crippler the guy who first classified schizophrenia,

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<v Speaker 1>call it the annihilation of the will, where you're just

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<v Speaker 1>so withdrawn you can't. You no longer engage in gold

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<v Speaker 1>directive behavior, from brushing your teeth to paying your bills

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<v Speaker 1>to doing anything. You just totally withdrawn. So that's that's

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<v Speaker 1>that's not the form of schizophrenia you usually hear about,

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<v Speaker 1>but apparently it's fairly common. Yeah, so get diagnosed. Uh, Josh,

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<v Speaker 1>you have to um, exhibit a certain number of these

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<v Speaker 1>symptoms over at least six months without stopping. Right. Yeah, um,

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<v Speaker 1>if you have uh, is it schizophrenic form? Is like

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<v Speaker 1>a shorter it's schizophrenia, but it lasts less than six months. Yeah,

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<v Speaker 1>that's schizophrenic form. Good point. But if you according to

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<v Speaker 1>the d s M, and we should say like this

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<v Speaker 1>is you know, it's based on clinical observations or whatever,

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<v Speaker 1>but this is the d s M saying six months,

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<v Speaker 1>it may be you may have schizophrenia and you just

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<v Speaker 1>haven't reached the six months you know period yet, but

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<v Speaker 1>you're still schizophrenic. But to be diagnosed by a psychiatrist

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<v Speaker 1>or a psychologist who's a member of the a p A,

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<v Speaker 1>you have to have X number of symptoms for six

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<v Speaker 1>months or more. Yeah, and they have to do that

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<v Speaker 1>because it's like the same as the cops when they say,

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<v Speaker 1>you can't find a missing person's report unless they've been

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<v Speaker 1>gone for twenty four hours. And it's not like that,

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<v Speaker 1>but it's sort of like that. Now there's like a law,

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<v Speaker 1>I think in Michigan called Kaylee's Law or something that

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<v Speaker 1>they're introducing where if you're a parent and you don't

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<v Speaker 1>report your kid missing after twenty four hours is a felony. Really,

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<v Speaker 1>what kind of parent wouldn't do that? The parent that

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<v Speaker 1>Casey Anthony, Yeah, made the kid go away allegedly alleged.

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<v Speaker 1>Not In general. Uh, schizophrenia apparently, as how it's pronounced,

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<v Speaker 1>can take a few forms. Uh. One you've probably heard

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<v Speaker 1>about most is paranoid schizophrenia, which is when you have

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<v Speaker 1>the full on delusions and hallucinations and uh, then there's

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<v Speaker 1>disorganized that is disorganized thinking. Uh, your behavior is probably incoherent.

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<v Speaker 1>It's also called hypophrenic. Really and you you probably don't

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<v Speaker 1>exhibit a lot of emotion. Yeah. Well, usually like there's

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<v Speaker 1>a negative simp them coupled with um disorganized behavior, so

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<v Speaker 1>it's almost like two separate things. I think you can

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<v Speaker 1>be hypophrenic without being negative. There's catatonic um that means

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<v Speaker 1>you move around and talk excessively. Um. Yeah, that was

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<v Speaker 1>a surprise to me. I always thought, you know, catatonic

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<v Speaker 1>state where you're just like's not a thing too. But

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<v Speaker 1>it also says they may become still an uncommunicat so

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<v Speaker 1>it can be one or the other. Yeah, but I

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<v Speaker 1>guess it has to do with motion or movement or

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<v Speaker 1>lack of. It's catatonic. Undifferentiated means that it's just sort

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<v Speaker 1>of the umbrella term for when you have a mix

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<v Speaker 1>of symptoms and they don't want to classify you as

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<v Speaker 1>one specific kind. And then residual is if you have

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<v Speaker 1>a history um of schizophrenia but you have a long,

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<v Speaker 1>extended period of time with no negative I'm sorry, with

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<v Speaker 1>negative but no positive symptoms, they'll classify you as residual,

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<v Speaker 1>which you know, I guess that's better than paranoid schizophrenia

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<v Speaker 1>in a way. I don't think any form of schizophrenia

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<v Speaker 1>is right. It would that would be it would be horrible.

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<v Speaker 1>This is a horrible disease. That's like the curb your enthusiasm.

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<v Speaker 1>When Larry asked if that some one had Good Hodgkins

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<v Speaker 1>from the Party of five episode is what he was

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<v Speaker 1>referencing when Charlie got sick. He had quote unquote good

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<v Speaker 1>Hodgkins and they were like, they were so offended. There

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<v Speaker 1>there's no good Hodgens. He's like, yeah, but one's better

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<v Speaker 1>than the other, right, And they were just like, you're

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<v Speaker 1>such a jerky never seen anything like that, Yeah, pretty much. Uh.

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<v Speaker 1>And then we mentioned schizophrenic form, which is an abbreviated

0:13:38.559 --> 0:13:42.400
<v Speaker 1>version of schizophrenia, and then this one has to be

0:13:42.440 --> 0:13:47.000
<v Speaker 1>just horrible schizo effective disorder. It's any kind of schizophrenia

0:13:47.400 --> 0:14:19.400
<v Speaker 1>couple with the mood disorder like depression. All right, so um,

0:14:19.480 --> 0:14:25.600
<v Speaker 1>we should probably say there's delusions and there's hallucinations, uh,

0:14:26.040 --> 0:14:31.360
<v Speaker 1>mixed in together often with schizophrenic symptoms, and they're often confused.

0:14:31.360 --> 0:14:36.040
<v Speaker 1>But a delusion is a false belief and and hallucination

0:14:36.160 --> 0:14:39.280
<v Speaker 1>is a false sensation like Hey, I'm Jesus Christ. That

0:14:39.280 --> 0:14:43.440
<v Speaker 1>would be a delusion, or hey there's Jesus Christ on

0:14:43.480 --> 0:14:46.760
<v Speaker 1>top of that subway car, that would be a hallucination. Yeah,

0:14:47.640 --> 0:14:50.080
<v Speaker 1>and you can extend that to anything. It doesn't have

0:14:50.160 --> 0:14:54.720
<v Speaker 1>to be Jesus or a subway car. Um. But the

0:14:54.720 --> 0:15:00.600
<v Speaker 1>there's just studying hallucinations and delusions are really really interesting

0:15:00.640 --> 0:15:06.520
<v Speaker 1>in my opinion. Um, the most common hallucination is auditory

0:15:06.600 --> 0:15:11.560
<v Speaker 1>among schizophrenics, and the most common auditory hallucination is our voices. Yeah,

0:15:11.600 --> 0:15:15.960
<v Speaker 1>they hear voices that can come from anywhere from this kermit,

0:15:16.000 --> 0:15:18.600
<v Speaker 1>the frog could start talking to me, or it could

0:15:19.040 --> 0:15:22.280
<v Speaker 1>come from thin air, or it could come from the

0:15:22.320 --> 0:15:28.360
<v Speaker 1>electrical outlet in the wall. Um and uh, the voices say.

0:15:29.160 --> 0:15:31.560
<v Speaker 1>Usually it's like one word, a couple of words, there's

0:15:31.560 --> 0:15:37.480
<v Speaker 1>an implication of word. Sometimes it's indistinct mumbling. Um. On occasion,

0:15:37.640 --> 0:15:42.160
<v Speaker 1>very rare occasions, will the voice like ramble on coherently

0:15:42.880 --> 0:15:46.840
<v Speaker 1>where the patient understands, like long sentences, but um that

0:15:47.000 --> 0:15:50.120
<v Speaker 1>they also maybe commenting on what the person is doing

0:15:50.240 --> 0:15:54.840
<v Speaker 1>is very um common. Yeah, Usually it's um, not a

0:15:54.920 --> 0:15:57.760
<v Speaker 1>voice that they recognize, although that can happen as well.

0:15:57.960 --> 0:16:00.440
<v Speaker 1>Yeah right, Uh. And then sometimes there's more than one

0:16:00.520 --> 0:16:04.040
<v Speaker 1>voice and even more disconcerting, lee, the voices will argue

0:16:04.120 --> 0:16:10.560
<v Speaker 1>about the patient, which that's wow, Well those I mean,

0:16:11.280 --> 0:16:13.600
<v Speaker 1>there's a guy on Martha that I see that and

0:16:13.640 --> 0:16:15.240
<v Speaker 1>a lot of people that you see that are walking

0:16:15.240 --> 0:16:19.080
<v Speaker 1>down the streets screaming out out loud. They there's probably

0:16:19.120 --> 0:16:21.800
<v Speaker 1>a pretty good chance that they might be paranoid schizophrenics,

0:16:21.880 --> 0:16:23.600
<v Speaker 1>and they are yelling at the voice in their head.

0:16:23.800 --> 0:16:25.560
<v Speaker 1>That reminds me of the stand up that I saw

0:16:25.560 --> 0:16:28.200
<v Speaker 1>when I was a kid in the eighties. Uh. This

0:16:28.240 --> 0:16:31.160
<v Speaker 1>guy was like this. This comedian said he was walking

0:16:31.160 --> 0:16:33.040
<v Speaker 1>down the street and he walked past this guy was

0:16:33.120 --> 0:16:36.760
<v Speaker 1>talking to himself and it's just mumbling, sounded so angry,

0:16:36.800 --> 0:16:40.120
<v Speaker 1>and the comedian goes and I thought, man, that guy

0:16:40.240 --> 0:16:43.520
<v Speaker 1>is really crazy. He's talking to himself. And then I thought, wait,

0:16:43.520 --> 0:16:48.560
<v Speaker 1>who am I talking to? Yeah, it's a good point. Yeah,

0:16:48.680 --> 0:16:50.840
<v Speaker 1>I talked to myself all day long. I have arguments

0:16:50.840 --> 0:16:55.360
<v Speaker 1>in my head. But of course it's not the same thing. No, um, no,

0:16:55.720 --> 0:16:58.440
<v Speaker 1>you don't have two voices arguing over what you're doing

0:16:58.520 --> 0:17:00.840
<v Speaker 1>at that moment and what's best for you or whether

0:17:00.880 --> 0:17:03.520
<v Speaker 1>you should hurt somebody or hurt yourself. Not making light

0:17:03.560 --> 0:17:07.240
<v Speaker 1>of that. Uh. And the reason that a percentage of

0:17:07.720 --> 0:17:11.159
<v Speaker 1>frightening percentage of schizophrenics kill themselves is a lot of

0:17:11.200 --> 0:17:13.520
<v Speaker 1>times because the voice in their head may command them

0:17:13.560 --> 0:17:16.120
<v Speaker 1>to do so. Right there, there, there's such a thing

0:17:16.320 --> 0:17:21.280
<v Speaker 1>as um commanding hallucinations. Which is sometimes they could be

0:17:21.320 --> 0:17:27.480
<v Speaker 1>suggestive like, um, maybe we should go outside for a while,

0:17:27.800 --> 0:17:31.000
<v Speaker 1>or they could be like go outside, you know. And

0:17:31.000 --> 0:17:33.280
<v Speaker 1>it's not always scary, like they just point out. Sometimes

0:17:33.280 --> 0:17:35.600
<v Speaker 1>it's uh, hey you need to shave again, right, and

0:17:35.600 --> 0:17:37.879
<v Speaker 1>you'll go shave again. Yeah, it can be innocuous, but

0:17:37.920 --> 0:17:41.000
<v Speaker 1>it can it can lead to violence, or it can

0:17:41.119 --> 0:17:44.479
<v Speaker 1>urge violence. Apparently the vast majority of people who suffer

0:17:45.720 --> 0:17:50.720
<v Speaker 1>uh dangerous command hallucinations are able to suppress them. But

0:17:50.840 --> 0:17:53.399
<v Speaker 1>it's a struggle and you know this is going on

0:17:53.440 --> 0:17:56.560
<v Speaker 1>in this person's head. Yeah, and rarely. And I wondered

0:17:56.560 --> 0:17:58.320
<v Speaker 1>about this too before I got to that point in

0:17:58.320 --> 0:18:01.120
<v Speaker 1>the article that you sent me early. Do you hear

0:18:01.960 --> 0:18:05.200
<v Speaker 1>like a really great things, like you're doing great today

0:18:05.240 --> 0:18:09.160
<v Speaker 1>and you should go and smell it. You know. It's

0:18:09.200 --> 0:18:13.359
<v Speaker 1>interesting that it usually takes a dark turn and they

0:18:13.359 --> 0:18:18.359
<v Speaker 1>don't know why. No, they don't. Um. There's also hallucinations

0:18:18.359 --> 0:18:23.040
<v Speaker 1>of touch haptic hallucinations, which sound pretty awful. Um, things

0:18:23.080 --> 0:18:25.560
<v Speaker 1>are crawling on you, things are inside of you trying

0:18:25.560 --> 0:18:30.720
<v Speaker 1>to get out. Your bowels are shriveling. Um, you're being

0:18:30.800 --> 0:18:34.120
<v Speaker 1>jolted by electricity is a very common one. And then

0:18:34.600 --> 0:18:38.280
<v Speaker 1>delusions obviously, or any like any false belief. There's some

0:18:38.480 --> 0:18:42.960
<v Speaker 1>that like you are Jesus Christ. That's a delusion, right, um.

0:18:43.000 --> 0:18:47.120
<v Speaker 1>But there's there was one subcategory that caught my attention

0:18:47.119 --> 0:18:50.320
<v Speaker 1>that I wasn't aware of. It's called delusion of reference. Yeah,

0:18:50.359 --> 0:18:52.960
<v Speaker 1>tell me about that. Well. It's basically like every single

0:18:53.000 --> 0:18:57.760
<v Speaker 1>thing that goes on in life is full of meaning. Right. So,

0:18:57.840 --> 0:19:01.200
<v Speaker 1>like in this Brown University sheet I sent you, there's

0:19:01.240 --> 0:19:05.439
<v Speaker 1>a like a waiter leaving a chroma on the table.

0:19:05.960 --> 0:19:08.560
<v Speaker 1>That's purposeful. It's an insult to the patient, like the

0:19:08.880 --> 0:19:11.800
<v Speaker 1>the busboy or the waiter did that on purpose as

0:19:11.840 --> 0:19:16.240
<v Speaker 1>an insult or Um. The street lights coming on all

0:19:16.240 --> 0:19:18.080
<v Speaker 1>of a sudden, it is a signal for everybody to

0:19:18.119 --> 0:19:20.640
<v Speaker 1>swarm on you and finally take you away or kill

0:19:20.680 --> 0:19:24.639
<v Speaker 1>you or whatever. Like everything in life has meaning and

0:19:24.680 --> 0:19:28.200
<v Speaker 1>it's making you. It's it's fueling this paranoia. Your mind

0:19:28.240 --> 0:19:33.240
<v Speaker 1>is turning against you. It's pretty awful. We said, it's awful. Yeah, okay, yes,

0:19:33.359 --> 0:19:38.000
<v Speaker 1>it is quite awful. Um, But people live with this. Yeah.

0:19:38.040 --> 0:19:39.920
<v Speaker 1>I mean we painted a dark picture because it is

0:19:39.960 --> 0:19:44.000
<v Speaker 1>a dark disorder, but the majority of people in fact

0:19:44.320 --> 0:19:48.679
<v Speaker 1>stet time. Uh after ten years. If you want to know,

0:19:49.160 --> 0:19:56.439
<v Speaker 1>after ten years of diagnosis with schizophrenia completely recover are

0:19:56.520 --> 0:20:01.240
<v Speaker 1>much improved and relatively independent. And percent are improved but

0:20:01.400 --> 0:20:07.359
<v Speaker 1>require a pretty extensive support network. So that's of people

0:20:07.400 --> 0:20:10.959
<v Speaker 1>after diagnosis after a decade, are are dealing with it

0:20:11.240 --> 0:20:15.120
<v Speaker 1>fairly well. Um, that's it's very hopeful. That's not bad.

0:20:15.920 --> 0:20:21.240
<v Speaker 1>Are unimproved. Ten percent, unfortunately, are dead, probably by suicide. Yeah, well,

0:20:21.320 --> 0:20:25.600
<v Speaker 1>ten percent at least of UM schizophrenics commit suicide, which

0:20:25.640 --> 0:20:30.480
<v Speaker 1>is incredibly high because in the general population of the

0:20:30.560 --> 0:20:36.000
<v Speaker 1>United States, point zero one percent of people commit suicide

0:20:36.560 --> 0:20:38.879
<v Speaker 1>to point zero one percent. Yeah, and that's people who

0:20:39.080 --> 0:20:41.359
<v Speaker 1>are successful. They think it could be attempts could be

0:20:41.400 --> 0:20:44.320
<v Speaker 1>as high as f people that try to kill themselves.

0:20:45.440 --> 0:20:47.920
<v Speaker 1>Just uh, I mean imagine sometimes the voices say to

0:20:47.960 --> 0:20:51.320
<v Speaker 1>do it, and sometimes it's just a fine piece. Yeah.

0:20:51.359 --> 0:20:57.520
<v Speaker 1>I was wondering what the breakdown between those two is. UM.

0:20:57.600 --> 0:21:02.400
<v Speaker 1>And then violence is often attendant with schizophrenics, at least

0:21:02.400 --> 0:21:07.360
<v Speaker 1>in the public mind, right, but you're dangerous. Apparently studies

0:21:07.359 --> 0:21:10.080
<v Speaker 1>have shown I remember reading about this when we talked

0:21:10.080 --> 0:21:15.240
<v Speaker 1>about latent inhibition. Um that if you are typically violent

0:21:16.400 --> 0:21:21.000
<v Speaker 1>when these uh, when the symptoms set when you're like

0:21:21.040 --> 0:21:24.320
<v Speaker 1>early twenties or whatever. Um, you're going to possibly be

0:21:24.359 --> 0:21:27.160
<v Speaker 1>a violent schizophrenic. If you're not a very violent person,

0:21:27.200 --> 0:21:31.320
<v Speaker 1>you're it's just not part of your personality before the

0:21:31.400 --> 0:21:33.760
<v Speaker 1>symptoms set in. Then you're not going to be a

0:21:33.840 --> 0:21:38.800
<v Speaker 1>violence schizophrenic unless you abuse drugs or alcohol, which apparently

0:21:39.440 --> 0:21:43.560
<v Speaker 1>vastly increases the chances that you may be a violence schizophrenic. Yeah,

0:21:43.600 --> 0:21:45.960
<v Speaker 1>and even then, I think the violence is generally either

0:21:46.000 --> 0:21:49.679
<v Speaker 1>self inflicted or it takes place inside the home, like

0:21:49.760 --> 0:21:52.800
<v Speaker 1>against your family, which is not good. But the point is,

0:21:52.840 --> 0:21:55.240
<v Speaker 1>if you're walking down the street and sadly you see

0:21:55.280 --> 0:21:59.960
<v Speaker 1>the homeless man screaming out loud, you don't necessarily need

0:22:00.000 --> 0:22:03.000
<v Speaker 1>to be afraid that he's about to, you know, attack

0:22:03.080 --> 0:22:05.840
<v Speaker 1>you in a violent manner. Right, that's probably not going

0:22:05.880 --> 0:22:08.600
<v Speaker 1>to happen, Chuck. Let's say you do want to talk

0:22:08.640 --> 0:22:11.800
<v Speaker 1>to that schizophrenic homeless man over there, but you don't

0:22:11.800 --> 0:22:15.359
<v Speaker 1>want to make things worse for him, right, But you

0:22:15.359 --> 0:22:18.919
<v Speaker 1>don't want to ignore him. He's another human being. Um.

0:22:19.000 --> 0:22:24.760
<v Speaker 1>The National Institutes of Mental Health have UM suggestions I

0:22:24.800 --> 0:22:28.480
<v Speaker 1>guess for talking to schizophrenics and specifically with their families

0:22:28.760 --> 0:22:32.240
<v Speaker 1>who have to deal with delusions and hallucinations all the time,

0:22:32.320 --> 0:22:38.919
<v Speaker 1>specifically delusions. Um, apparently you don't. You don't contest what

0:22:38.960 --> 0:22:41.200
<v Speaker 1>they're saying. Yeah, you don't want to say you're not

0:22:41.520 --> 0:22:44.640
<v Speaker 1>Jesus Christ what you're talking about. Yeah, you don't. Definitely

0:22:44.640 --> 0:22:49.200
<v Speaker 1>don't know. You say, um, I respect your right to

0:22:49.240 --> 0:22:51.760
<v Speaker 1>believe different things, and I hope you'll respect my right

0:22:51.840 --> 0:22:55.920
<v Speaker 1>to believe different things. But I I, you know, politely disagree.

0:22:56.040 --> 0:22:57.960
<v Speaker 1>And what you also don't want to do is agree

0:22:58.000 --> 0:23:01.400
<v Speaker 1>and say I know, honey, you are Jesus. Right, You're okay,

0:23:01.440 --> 0:23:04.040
<v Speaker 1>you're Jesus and it's fine. Yes. A lot of people

0:23:04.119 --> 0:23:07.080
<v Speaker 1>probably take that tack in the family, you know, well, yeah, first,

0:23:07.200 --> 0:23:08.879
<v Speaker 1>I mean, at the very least, because it's it's just

0:23:09.000 --> 0:23:12.439
<v Speaker 1>easier after a while, it's like yes, yes, or you

0:23:12.480 --> 0:23:14.480
<v Speaker 1>get so frustrated you're like no, you're not, and you

0:23:14.480 --> 0:23:18.960
<v Speaker 1>want to shake the person. Um. But yeah, apparently, And

0:23:18.960 --> 0:23:22.639
<v Speaker 1>I wonder how hard it is to say, well, I

0:23:22.880 --> 0:23:25.760
<v Speaker 1>respectfully disagree with you. Yeah. I bet it's hard, you know,

0:23:25.840 --> 0:23:27.760
<v Speaker 1>and if it, if it does go over as well

0:23:27.800 --> 0:23:32.359
<v Speaker 1>as as it seems like it that it suggested it should, right,

0:23:32.560 --> 0:23:35.280
<v Speaker 1>you know, all right, Josh, I think this was really interesting,

0:23:35.359 --> 0:23:38.960
<v Speaker 1>the recovery in the Third World part. Yeah, Apparently the

0:23:39.000 --> 0:23:42.520
<v Speaker 1>World Health Organization did a study in the nineteen sixties

0:23:43.280 --> 0:23:46.520
<v Speaker 1>and uh I found that the recovery rate for schizophrenia

0:23:46.560 --> 0:23:51.080
<v Speaker 1>and developing nations is higher by a full third than

0:23:51.119 --> 0:23:53.959
<v Speaker 1>it is in the industrialized world. And then they did

0:23:54.000 --> 0:23:58.720
<v Speaker 1>a follow up study even to correct possible selection biases,

0:23:58.800 --> 0:24:01.920
<v Speaker 1>and they confirmed the original all finding, and I thought

0:24:01.920 --> 0:24:05.080
<v Speaker 1>that was really interesting. And they There's a lot of hypotheses,

0:24:05.080 --> 0:24:08.320
<v Speaker 1>but one of them is that a there might not

0:24:08.400 --> 0:24:12.160
<v Speaker 1>be a stigma like in the industrialized world, and they're

0:24:12.200 --> 0:24:15.200
<v Speaker 1>just more readily accepted. And the other is that they

0:24:15.280 --> 0:24:17.760
<v Speaker 1>might be able to have a job that they can

0:24:18.040 --> 0:24:22.320
<v Speaker 1>do successfully. And here in the West, farming or digging,

0:24:22.600 --> 0:24:24.560
<v Speaker 1>you know, digging the trench for the farm or whatever.

0:24:25.160 --> 0:24:27.960
<v Speaker 1>Here in the West were very competitive. Yeah, it's hard

0:24:28.000 --> 0:24:31.639
<v Speaker 1>to get a job that a schizophrenic can maybe successfully complete, right,

0:24:31.720 --> 0:24:34.160
<v Speaker 1>And I mean, the rest of us are paranoid enough

0:24:34.200 --> 0:24:36.199
<v Speaker 1>as it is about losing our jobs. If you are

0:24:36.280 --> 0:24:40.600
<v Speaker 1>clinically paranoid schizophrenic, then it's probably going to be very

0:24:40.640 --> 0:24:43.280
<v Speaker 1>difficult to keep your job true or do it in

0:24:43.320 --> 0:24:45.240
<v Speaker 1>a way that will help you keep your job. That's

0:24:45.320 --> 0:24:49.119
<v Speaker 1>very true. But Josh, there have been some successful stories

0:24:49.280 --> 0:24:53.400
<v Speaker 1>of people that are afflicted with schizophrenia. Well, some some

0:24:53.440 --> 0:24:58.080
<v Speaker 1>more successful and some Sid Barrett was successful, but I

0:24:58.119 --> 0:25:00.080
<v Speaker 1>don't know if you call him a success story. Was

0:25:00.280 --> 0:25:02.680
<v Speaker 1>up in a mental institution for the rest of his life. Yeah,

0:25:02.720 --> 0:25:06.360
<v Speaker 1>said Barrett, founding member of Pink Floyd schizophrenic, and they

0:25:06.359 --> 0:25:08.960
<v Speaker 1>believe that massive amounts of drugs that he used made

0:25:08.960 --> 0:25:12.280
<v Speaker 1>it worse, way worse. John, he is he is the

0:25:12.359 --> 0:25:15.800
<v Speaker 1>crazy Diamond. Yeah, shine on you, Crazy Diamond. I love

0:25:15.840 --> 0:25:19.080
<v Speaker 1>that song. That's a good one. All four parts of it, right,

0:25:19.920 --> 0:25:21.960
<v Speaker 1>and they're like part I think up to part four,

0:25:22.119 --> 0:25:25.720
<v Speaker 1>is it? Yeah? Yeah, John Nash, Yeah, from the movie

0:25:26.119 --> 0:25:29.480
<v Speaker 1>A Beautiful Mind, the Ron Howard film with Russell Crowe

0:25:29.560 --> 0:25:33.000
<v Speaker 1>as John Nash, the Nobel winner to figure out that

0:25:33.040 --> 0:25:37.080
<v Speaker 1>cable companies would do better if they cooperated with one another.

0:25:37.760 --> 0:25:39.560
<v Speaker 1>That's right, And that movie did a lot for putting

0:25:39.560 --> 0:25:41.480
<v Speaker 1>this on the map in a compassionate way, you know.

0:25:42.040 --> 0:25:44.520
<v Speaker 1>And Jack Caro whact did you know that one? That

0:25:44.560 --> 0:25:47.440
<v Speaker 1>one's debatable. Okay. He was in the Navy and they

0:25:47.560 --> 0:25:51.120
<v Speaker 1>discharged him honorably after I think like a little less

0:25:51.119 --> 0:25:54.040
<v Speaker 1>than a year and and the report they said he

0:25:54.080 --> 0:25:58.719
<v Speaker 1>had schizoid tendencies. But um, other people have said that

0:25:58.760 --> 0:26:01.760
<v Speaker 1>he faked that stuff to get out of the navy,

0:26:01.880 --> 0:26:05.160
<v Speaker 1>uh and just wanted to not take orders and drink

0:26:05.240 --> 0:26:07.680
<v Speaker 1>himself to death, which is what he did. And Pop

0:26:07.720 --> 0:26:12.040
<v Speaker 1>Benny's do you know how he died? No, he woke

0:26:12.160 --> 0:26:15.960
<v Speaker 1>up and was just like coughing blood and bleeding from

0:26:15.960 --> 0:26:18.880
<v Speaker 1>his mouth and basically was like, I gotta go the hospital.

0:26:19.359 --> 0:26:22.480
<v Speaker 1>Took him to the hospital and he was his liver

0:26:22.640 --> 0:26:26.000
<v Speaker 1>was so shot that his blood wooden clot and they

0:26:26.119 --> 0:26:29.399
<v Speaker 1>just were giving him transfusion one after the other and

0:26:29.440 --> 0:26:32.959
<v Speaker 1>he just basically bled to death. Holy cow from drinking

0:26:33.160 --> 0:26:36.320
<v Speaker 1>Holy cow. And he was drinking at the time. He

0:26:36.400 --> 0:26:40.560
<v Speaker 1>was drinking whiskey and uh like whiskey and malt liquor.

0:26:41.119 --> 0:26:43.640
<v Speaker 1>When he started blood started coming out of his mouth.

0:26:44.840 --> 0:26:47.159
<v Speaker 1>I wonder how it tastes. Would you shake or stir that?

0:26:47.400 --> 0:26:49.119
<v Speaker 1>And I don't think he mixed him. I think he

0:26:49.200 --> 0:26:51.800
<v Speaker 1>was like whiskey with a beer back in a garness

0:26:51.840 --> 0:26:55.440
<v Speaker 1>with a drop of blood. So, kids, there's a lesson

0:26:55.480 --> 0:26:59.040
<v Speaker 1>for you there. Here. There's one more person who is

0:26:59.080 --> 0:27:04.199
<v Speaker 1>indisputably schizophrenic or was His name is Wesley Willis. Who's that?

0:27:04.520 --> 0:27:08.480
<v Speaker 1>He is a musician who had such songs as well. Really,

0:27:08.560 --> 0:27:11.080
<v Speaker 1>the only title I can say is rock and roll McDonald's.

0:27:11.520 --> 0:27:15.439
<v Speaker 1>I don't I've never heard of him. You you have

0:27:15.680 --> 0:27:20.080
<v Speaker 1>had to have heard of Wesley Willis. Okay, let me

0:27:20.080 --> 0:27:27.720
<v Speaker 1>play you a little Wesley Willis right here. McDonald's is

0:27:27.720 --> 0:27:31.760
<v Speaker 1>a place to rock. It is a restaurant where they

0:27:31.800 --> 0:27:35.000
<v Speaker 1>buy food, beat. It is a good place to listen

0:27:35.000 --> 0:27:37.679
<v Speaker 1>to the music. People flock here to get down to

0:27:37.720 --> 0:27:48.880
<v Speaker 1>the rock music. Rocky romcdono, Rocky ro mcdono, brocka romdono,

0:27:49.760 --> 0:27:54.719
<v Speaker 1>rocky roommate, donle so Chuck. That's Wesley will Okay, Okay,

0:27:54.760 --> 0:27:58.480
<v Speaker 1>And um, he was very much schizophrenic. Um he wrote

0:27:58.520 --> 0:28:00.280
<v Speaker 1>about it a lot, He talked about it a lot

0:28:00.320 --> 0:28:02.800
<v Speaker 1>of his songs. And um, he said he'd just be

0:28:02.880 --> 0:28:06.280
<v Speaker 1>going along, having a nice time riding the bus. I

0:28:06.320 --> 0:28:09.199
<v Speaker 1>believe he lived in Chicago, and then all of a sudden,

0:28:09.280 --> 0:28:14.280
<v Speaker 1>his um, his hell demons would take him on one

0:28:14.280 --> 0:28:17.640
<v Speaker 1>of his torture hell rides, which meant he was going

0:28:17.720 --> 0:28:21.680
<v Speaker 1>on a little bit of an exacerbation of his schizophrenia symptoms.

0:28:21.720 --> 0:28:25.840
<v Speaker 1>But he's a great, great guy, great music, very prolific

0:28:26.080 --> 0:28:29.760
<v Speaker 1>and uh, if you liked that, you should go watch

0:28:30.160 --> 0:28:32.560
<v Speaker 1>Daddy of Rock and Roll as a documentary. But yeah,

0:28:32.600 --> 0:28:36.760
<v Speaker 1>it's really good. I'll check that out. Yeah, Lionel Aldridge

0:28:36.840 --> 0:28:38.480
<v Speaker 1>is a last name on our list. And he was

0:28:38.520 --> 0:28:42.120
<v Speaker 1>a Green Bay packer and he was homeless unfortunately after

0:28:42.200 --> 0:28:45.040
<v Speaker 1>he was diagnosed for a while and then later was

0:28:45.120 --> 0:28:49.360
<v Speaker 1>able to climb out from that wreckage and go around

0:28:49.400 --> 0:28:52.360
<v Speaker 1>and talk about mental illness. And he was he was

0:28:52.560 --> 0:28:56.960
<v Speaker 1>playing in the sixties, the seventies. I think it was

0:28:57.160 --> 0:28:59.640
<v Speaker 1>late sixties or seventies. So think about it. Man, that's

0:28:59.640 --> 0:29:02.520
<v Speaker 1>a big deal to go around and talk publicly about

0:29:02.640 --> 0:29:05.640
<v Speaker 1>mental illness at that time, and it still is now,

0:29:06.280 --> 0:29:09.160
<v Speaker 1>but I mean, like back then, that's hats off to him. Yeah,

0:29:09.200 --> 0:29:11.560
<v Speaker 1>he was the guy that I included in the presentation

0:29:11.600 --> 0:29:13.760
<v Speaker 1>that you did by yourself. Okay that you're like, he

0:29:13.880 --> 0:29:17.120
<v Speaker 1>was this guy? Yeah, all right, I understand now. Yeah,

0:29:17.120 --> 0:29:45.080
<v Speaker 1>it's all coming together. So chuck, um, what causes this? Well, uh,

0:29:45.400 --> 0:29:48.320
<v Speaker 1>it seems like there are environmental factors and there are

0:29:48.360 --> 0:29:51.920
<v Speaker 1>genetic factors. Um. They have isolated what they believe are

0:29:51.960 --> 0:29:57.440
<v Speaker 1>some genes, the d I, s C one, the disbanden,

0:29:57.640 --> 0:30:02.720
<v Speaker 1>the neuragoulin, and the G seven two genes, and they

0:30:02.800 --> 0:30:05.160
<v Speaker 1>think there might be up to a dozen more genes

0:30:05.200 --> 0:30:09.800
<v Speaker 1>that could impact this. Okay, So the basis of that

0:30:10.040 --> 0:30:12.120
<v Speaker 1>is that they can't just look at your genes and

0:30:12.200 --> 0:30:16.640
<v Speaker 1>say you're you're going to be schizophrenic. It's possible that

0:30:16.680 --> 0:30:18.920
<v Speaker 1>it's because we just haven't isolated all the genes and

0:30:18.960 --> 0:30:22.480
<v Speaker 1>don't know the right combination yet, or it's possible that

0:30:22.560 --> 0:30:26.200
<v Speaker 1>it's from other causes, one of which one of the

0:30:26.200 --> 0:30:28.959
<v Speaker 1>theories that's out there right now is that it's the

0:30:29.000 --> 0:30:32.840
<v Speaker 1>result of an in utero exposure to either a flu

0:30:33.640 --> 0:30:38.960
<v Speaker 1>or the dread toxoplasmosis. Remember toxoplasmosis that hijacks rats brains,

0:30:38.960 --> 0:30:41.320
<v Speaker 1>that's found in cat urine. That's why if you have

0:30:41.360 --> 0:30:43.600
<v Speaker 1>a cat and you're pregnant, you don't be clean enough

0:30:43.640 --> 0:30:46.200
<v Speaker 1>that litter box, right, um, And they think that one

0:30:46.200 --> 0:30:48.479
<v Speaker 1>of the reasons, well, I guess one of the evident

0:30:48.520 --> 0:30:50.720
<v Speaker 1>pieces of evidence that supports this is called the birth

0:30:50.760 --> 0:30:54.120
<v Speaker 1>month effect. And the birth month effect is um, if

0:30:54.200 --> 0:30:57.240
<v Speaker 1>you were born in winter months or early spring months,

0:30:57.680 --> 0:31:01.640
<v Speaker 1>you are at a higher risk for mean schizophrenics in life,

0:31:01.720 --> 0:31:04.880
<v Speaker 1>and they think that those are flu months UM. And

0:31:05.440 --> 0:31:08.400
<v Speaker 1>another aspect of it is apparently the brains of schizophrenics

0:31:08.400 --> 0:31:10.680
<v Speaker 1>show inflamed white blood cells, which is a sign of

0:31:10.720 --> 0:31:14.240
<v Speaker 1>an infection. And they think that possibly all of us

0:31:14.280 --> 0:31:17.560
<v Speaker 1>are carrying around a retrovirus encoded in our genes that

0:31:17.640 --> 0:31:22.120
<v Speaker 1>lies dormant like ms that under the right circumstances like

0:31:22.200 --> 0:31:26.880
<v Speaker 1>early exposure between infection um can trigger its release or

0:31:26.920 --> 0:31:30.160
<v Speaker 1>trigger its activation and it takes eighteen to twenty to

0:31:30.320 --> 0:31:33.960
<v Speaker 1>thirty years to come on. Now you see why people

0:31:33.960 --> 0:31:38.320
<v Speaker 1>that are pregnant are worried a lot. It's amazing that

0:31:38.560 --> 0:31:44.800
<v Speaker 1>like we've gotten anywhere. Yeah, so what else? Uh well,

0:31:44.840 --> 0:31:47.080
<v Speaker 1>they did do have some new findings. I got this today,

0:31:47.480 --> 0:31:52.080
<v Speaker 1>um from the internets. They have a new South Wales

0:31:53.120 --> 0:31:56.280
<v Speaker 1>study from Thomas which kert He has identified the brain

0:31:56.360 --> 0:32:00.680
<v Speaker 1>mechanism that derails decision making in people. So basically the

0:32:00.680 --> 0:32:03.440
<v Speaker 1>part of the brain is called the ventral stratium I'm sorry,

0:32:03.480 --> 0:32:06.360
<v Speaker 1>stry Adam, and it lights up you know, they put

0:32:06.400 --> 0:32:08.560
<v Speaker 1>people in the m all right, lights up when in

0:32:08.600 --> 0:32:11.960
<v Speaker 1>response to rewards and healthy people and it's linked to

0:32:12.000 --> 0:32:16.760
<v Speaker 1>your decision making. But completely unresponsive among schizophrenics. So they

0:32:16.800 --> 0:32:20.640
<v Speaker 1>don't uh, they don't know the difference between expected and

0:32:20.720 --> 0:32:24.520
<v Speaker 1>unexpected rewards, and so they don't have the opportunity to

0:32:24.560 --> 0:32:28.280
<v Speaker 1>make a good decision to begin with. And that, you know,

0:32:28.800 --> 0:32:30.560
<v Speaker 1>it's a it's a nice finding. It doesn't get us

0:32:30.560 --> 0:32:34.240
<v Speaker 1>any closer. Well, maybe it does, you never know. They say,

0:32:34.280 --> 0:32:38.520
<v Speaker 1>with proper funding that they predicted they could have a

0:32:38.560 --> 0:32:41.840
<v Speaker 1>cure for this. Well, yeah, but they don't get proper funding.

0:32:42.520 --> 0:32:46.520
<v Speaker 1>But they're UM. They're looking into stem cells, right, they're

0:32:46.520 --> 0:32:50.640
<v Speaker 1>looking into UM figuring out if it is an infection

0:32:51.320 --> 0:32:55.520
<v Speaker 1>and if so like adding that UM. And we've also

0:32:55.600 --> 0:32:59.720
<v Speaker 1>long had antipsychotics. One of the things, strangely enough, that

0:33:00.000 --> 0:33:05.640
<v Speaker 1>helped developed anti psychotics, or better antipsychotics UM is PCP.

0:33:06.960 --> 0:33:12.160
<v Speaker 1>Apparently researchers figured out that UM phenyl cycladine UM or

0:33:12.240 --> 0:33:18.560
<v Speaker 1>fencycladin PCP, the drug angel dust UM, produced such similar

0:33:18.600 --> 0:33:23.040
<v Speaker 1>symptoms to schizophrenia that they started investigating and found that

0:33:23.080 --> 0:33:28.440
<v Speaker 1>it had to do with UM the neurotransmitter glutamate, right, right,

0:33:29.040 --> 0:33:31.480
<v Speaker 1>domine right, Yes, well it has to do with both.

0:33:31.520 --> 0:33:35.040
<v Speaker 1>But the emphasis before on anti psychotics was strictly dopamine

0:33:35.720 --> 0:33:38.479
<v Speaker 1>and all it all it did was keep dopamine in

0:33:38.520 --> 0:33:42.320
<v Speaker 1>the synapse is longer by blocking its reuptake by receptors.

0:33:42.320 --> 0:33:45.560
<v Speaker 1>That's what antipsychotics do. And then in the eighties, after

0:33:45.600 --> 0:33:49.240
<v Speaker 1>the PCP stuff, UM, they figured out that there was

0:33:50.240 --> 0:33:54.280
<v Speaker 1>glutamate was involved and they came up with a typical antipsychotics,

0:33:54.720 --> 0:33:58.000
<v Speaker 1>and these focus somewhat on dopamine, but more on things

0:33:58.000 --> 0:34:01.480
<v Speaker 1>like glutamate and it's re up to ache and uh.

0:34:01.520 --> 0:34:05.600
<v Speaker 1>These things have produced better results with fewer side effects,

0:34:06.120 --> 0:34:08.960
<v Speaker 1>so um, they're they're figuring out how to treat it.

0:34:09.560 --> 0:34:12.080
<v Speaker 1>The problem is that there's all sorts of side effects

0:34:12.080 --> 0:34:18.680
<v Speaker 1>even even with atypical UM antipsychotics, like weight gain, drowsiness, servishness, nervousness,

0:34:18.760 --> 0:34:24.320
<v Speaker 1>muscle spasms, yeah allum. Bulging eyes apparently is one, and

0:34:24.760 --> 0:34:26.680
<v Speaker 1>I guess most of the stuff can be treated by

0:34:26.680 --> 0:34:29.480
<v Speaker 1>lowering the dosage, but they're they're bothersome enough that a

0:34:29.520 --> 0:34:33.040
<v Speaker 1>lot of people just go off their meds, and you

0:34:33.080 --> 0:34:36.520
<v Speaker 1>know that doesn't help ect. Electro Convulsive therapy is another

0:34:36.560 --> 0:34:39.000
<v Speaker 1>thing that they still do. It's not something a relic

0:34:39.120 --> 0:34:41.759
<v Speaker 1>from the fifties. It's changed a lot, and how they

0:34:41.760 --> 0:34:44.960
<v Speaker 1>do it and they're not sure still how it exactly works.

0:34:45.000 --> 0:34:49.520
<v Speaker 1>They stopped using car batteries, but about a hundred thousand

0:34:49.840 --> 0:34:54.680
<v Speaker 1>Americans each year still receive e c T, So that

0:34:54.800 --> 0:34:57.920
<v Speaker 1>is an option. And obviously the group therapy and family

0:34:57.960 --> 0:35:01.880
<v Speaker 1>therapy help just the dealing with it aspect of the family. Yes,

0:35:02.239 --> 0:35:05.040
<v Speaker 1>so we encourage you to seek help as soon as possible. Yeah,

0:35:05.040 --> 0:35:07.960
<v Speaker 1>And apparently families can help in very little ways. They're

0:35:08.000 --> 0:35:13.239
<v Speaker 1>encouraged to UM set small goals. Apparently, if especially if

0:35:13.280 --> 0:35:16.520
<v Speaker 1>you UM have lost your drive or your will as

0:35:16.520 --> 0:35:20.520
<v Speaker 1>a result of your schizophrenia, or you're disorganized, it can

0:35:20.560 --> 0:35:23.399
<v Speaker 1>just be compounded by all the you know, like when

0:35:23.440 --> 0:35:28.120
<v Speaker 1>your life is disorganized, it seems just completely unwieldy, Like

0:35:28.160 --> 0:35:30.120
<v Speaker 1>where do I start right now? If if that's a

0:35:30.160 --> 0:35:33.160
<v Speaker 1>symptom of your schizophrenia, it's it's just that much worse.

0:35:33.520 --> 0:35:35.960
<v Speaker 1>So if you can help a schizophrenic get back on

0:35:36.000 --> 0:35:39.360
<v Speaker 1>track by setting small goals and building up their confidence again,

0:35:39.480 --> 0:35:45.200
<v Speaker 1>apparently that has a measurable effect in their recovery UM

0:35:45.280 --> 0:35:49.000
<v Speaker 1>and then the like the one of the leading edges

0:35:49.040 --> 0:35:53.319
<v Speaker 1>of UM schizophrenia treatment right now is based on the

0:35:53.520 --> 0:35:58.880
<v Speaker 1>this thing called the per drome, which is the period

0:35:58.960 --> 0:36:03.000
<v Speaker 1>between on set of symptoms where you think maybe I

0:36:03.080 --> 0:36:06.239
<v Speaker 1>am Jesus Christ and the time when that seems like

0:36:06.280 --> 0:36:10.360
<v Speaker 1>your reality. So it's this point where you're starting to

0:36:10.400 --> 0:36:13.080
<v Speaker 1>have the ideas, but they still seem bizarre or weird

0:36:13.239 --> 0:36:16.440
<v Speaker 1>or why am I having these ideas? So if you

0:36:16.640 --> 0:36:21.239
<v Speaker 1>apparently seek out treatment for schizophrenia when you start to

0:36:21.280 --> 0:36:27.279
<v Speaker 1>have these ideas, um in the prodrome, the success rate

0:36:27.280 --> 0:36:32.080
<v Speaker 1>of treatment is through the roof. Like, Yes, this British

0:36:32.080 --> 0:36:34.239
<v Speaker 1>doctor in the late eighties set up shop in these

0:36:34.239 --> 0:36:37.680
<v Speaker 1>two towns outside of London and he's set to work

0:36:38.239 --> 0:36:43.440
<v Speaker 1>finding every potential early case of schizophrenia he could and

0:36:43.480 --> 0:36:46.360
<v Speaker 1>he started treating people with therapy and low doses of

0:36:46.400 --> 0:36:51.120
<v Speaker 1>anti psychotics and in four years those two towns had

0:36:51.120 --> 0:36:54.080
<v Speaker 1>a tenth of the prevalence of schizophrenia than the rest

0:36:54.120 --> 0:36:57.840
<v Speaker 1>of the country. Yeah, so apparently, like this pro drome research,

0:36:57.840 --> 0:37:00.640
<v Speaker 1>there's like clinics that are opening up and like entire

0:37:00.760 --> 0:37:04.240
<v Speaker 1>like departments in universities are dedicated to this per drome

0:37:04.360 --> 0:37:07.000
<v Speaker 1>period where you can be like, come, come back, come,

0:37:07.120 --> 0:37:10.960
<v Speaker 1>this is reality. Yeah, and they're successful or they have

0:37:11.040 --> 0:37:13.880
<v Speaker 1>been so far. Well, Josh, I got one more stat

0:37:13.960 --> 0:37:15.920
<v Speaker 1>if you live in a city of three million people,

0:37:16.760 --> 0:37:21.359
<v Speaker 1>then over twenty one thousand people in your city are

0:37:21.400 --> 0:37:25.120
<v Speaker 1>suffering from schizophrenia. So well keep that in mind. Yes,

0:37:25.480 --> 0:37:29.799
<v Speaker 1>don't make fun of people. Don't obviously get scared or

0:37:29.880 --> 0:37:33.759
<v Speaker 1>violent and in a reactive way. I don't know that.

0:37:33.800 --> 0:37:35.560
<v Speaker 1>I'm gonna say, like, you should go over and talk

0:37:35.600 --> 0:37:38.440
<v Speaker 1>to them, like you might want to just be compassionate

0:37:38.480 --> 0:37:41.000
<v Speaker 1>and uh and hopefully they're getting help, you know what

0:37:41.040 --> 0:37:43.440
<v Speaker 1>I'm saying. Yes, go to schizophrenia dot com. You can

0:37:43.440 --> 0:37:45.920
<v Speaker 1>find all kinds of good information. And if you hadn't

0:37:45.960 --> 0:37:48.200
<v Speaker 1>already checked out Wesley Willis, check him out. He was

0:37:48.200 --> 0:37:50.040
<v Speaker 1>a great guy. Check out The Daddy or Rock and

0:37:50.120 --> 0:37:53.120
<v Speaker 1>Roll and um, also, I would say, in addition to

0:37:53.400 --> 0:37:57.520
<v Speaker 1>how schizophrenia works, UM required reading for this one is

0:37:57.960 --> 0:38:01.680
<v Speaker 1>an article called Which Way Madness Lies? By Rachel Lviv.

0:38:01.800 --> 0:38:05.600
<v Speaker 1>It was in the December issue of Harper's And I

0:38:05.640 --> 0:38:07.880
<v Speaker 1>have a link. I'll I'll tweet it. I'll tweet the

0:38:07.880 --> 0:38:09.879
<v Speaker 1>link out with that. It sounds great. If you want

0:38:09.920 --> 0:38:13.200
<v Speaker 1>more about schizophrenia, UM, there's plenty of it. There's an

0:38:13.280 --> 0:38:17.080
<v Speaker 1>article and then some on the site. Just type schizophrenia,

0:38:17.920 --> 0:38:20.720
<v Speaker 1>which again means split mind. That's right into the search

0:38:20.760 --> 0:38:23.200
<v Speaker 1>bar at how stuff works dot com and that brings

0:38:23.280 --> 0:38:32.040
<v Speaker 1>up what chuck listener? Now, yes, Josh specifically corrections. Oh wow,

0:38:32.080 --> 0:38:34.640
<v Speaker 1>I forgot about those. Yeah. Well, well we'll correct ourselves

0:38:34.640 --> 0:38:38.479
<v Speaker 1>on Facebook and stuff. But they mounted up, so sure

0:38:38.560 --> 0:38:43.600
<v Speaker 1>we want us, we'll go for it. How wildfires work? Oh, man,

0:38:43.640 --> 0:38:45.600
<v Speaker 1>I don't have this guy's name. A couple of people

0:38:45.600 --> 0:38:48.839
<v Speaker 1>sending this in. Uh, the flashpoint of paper is not

0:38:48.920 --> 0:38:53.160
<v Speaker 1>fahrenheit for fifty one, I said books. The flash point

0:38:53.200 --> 0:38:55.680
<v Speaker 1>of books is not fahrenheit for fifty one. It is

0:38:55.719 --> 0:39:00.640
<v Speaker 1>fahrenheit eight fifty one celsius four fifty and a Bradbury

0:39:00.680 --> 0:39:04.720
<v Speaker 1>apparently changed the title because fahrenheit for fifty one sounds

0:39:04.760 --> 0:39:09.000
<v Speaker 1>a lot better than celsius for fifty Apparently what was one?

0:39:09.680 --> 0:39:14.359
<v Speaker 1>No celsius for fifty is the flashpoint or fahrenheight eight

0:39:15.440 --> 0:39:19.480
<v Speaker 1>sounds as good as four, I think, yeah, okay, but

0:39:19.640 --> 0:39:21.799
<v Speaker 1>I assume that as well. Man, I wish I had

0:39:21.800 --> 0:39:23.440
<v Speaker 1>his name. You know who you are. And it was

0:39:23.440 --> 0:39:24.920
<v Speaker 1>a very nice correction. Those are the ones we like

0:39:24.960 --> 0:39:28.080
<v Speaker 1>to read. Uh. Then we got a correction on who

0:39:28.120 --> 0:39:32.879
<v Speaker 1>was the first murderer. Apparently David says, and even sent

0:39:33.000 --> 0:39:37.200
<v Speaker 1>in a copy of one by Charles Mann. What where

0:39:38.400 --> 0:39:41.560
<v Speaker 1>what he's an email? No, not a not a He

0:39:41.640 --> 0:39:46.680
<v Speaker 1>sent a scanned copy of the page in he says.

0:39:47.400 --> 0:39:51.279
<v Speaker 1>Charles Mann says. Although Billington was in fact hanged, at

0:39:51.320 --> 0:39:54.920
<v Speaker 1>least two other Europeans were executed before him. One was

0:39:54.920 --> 0:39:57.360
<v Speaker 1>convicted for the much more interesting offense of killing his

0:39:57.400 --> 0:40:01.520
<v Speaker 1>pregnant wife and eating her. So how about that, he said,

0:40:01.520 --> 0:40:07.680
<v Speaker 1>those on page fifty five. Yeah, there it is. That

0:40:07.880 --> 0:40:11.640
<v Speaker 1>is crazy, okay, But still Billington is a very noteworthy figure.

0:40:11.640 --> 0:40:14.920
<v Speaker 1>Obviously sees a whole chapter on him. And then we

0:40:15.000 --> 0:40:17.919
<v Speaker 1>got some uh oh. First of all, some people wrote

0:40:17.960 --> 0:40:20.520
<v Speaker 1>in about wildfires in Georgia when I said, oh, Georgia,

0:40:20.520 --> 0:40:23.799
<v Speaker 1>and that wildfires South Georgia does, and there's actually one

0:40:23.840 --> 0:40:28.680
<v Speaker 1>going on right now in the Okefinoki. So I misspoke

0:40:28.960 --> 0:40:31.160
<v Speaker 1>for sure, because I was just talking about the North

0:40:31.160 --> 0:40:34.279
<v Speaker 1>Georgia mountains, which are very lush and green, but South

0:40:34.320 --> 0:40:37.840
<v Speaker 1>Georgia can get quite dry, and there are wildfires in Georgia.

0:40:38.560 --> 0:40:40.919
<v Speaker 1>I did not know that that is true. And then

0:40:40.960 --> 0:40:45.879
<v Speaker 1>finally we got an email from an actual Hindu named

0:40:45.920 --> 0:40:49.560
<v Speaker 1>kush k U s h and Kush says, you guys

0:40:49.560 --> 0:40:53.759
<v Speaker 1>missed a few things. Hinduism typically, I'm sorry, technically only

0:40:53.800 --> 0:40:57.440
<v Speaker 1>has one god, not a pantheon. It's complicated to explain,

0:40:57.560 --> 0:40:59.920
<v Speaker 1>especially no non Hindus. But the general ideas there is

0:41:00.360 --> 0:41:04.520
<v Speaker 1>one universal soul or god that encompasses everything, called the

0:41:04.560 --> 0:41:10.520
<v Speaker 1>brah Brahman, that not the Brohm, and every living thing

0:41:10.640 --> 0:41:13.719
<v Speaker 1>has a part of that in us called the Atman.

0:41:14.480 --> 0:41:18.200
<v Speaker 1>The different gods are just different forms of the one Brahman. Also,

0:41:18.239 --> 0:41:20.279
<v Speaker 1>you didn't properly explain the laws of karma. The law

0:41:20.320 --> 0:41:23.880
<v Speaker 1>of karma has three parts in Hinduism. One the performer

0:41:23.920 --> 0:41:26.360
<v Speaker 1>ofman action will get the result to the result of

0:41:26.400 --> 0:41:29.359
<v Speaker 1>the action will come right at the right time. And

0:41:29.440 --> 0:41:32.640
<v Speaker 1>three good actions bring good results, Bad actions bring bad results.

0:41:33.560 --> 0:41:36.640
<v Speaker 1>And fourth, the gods are technically subject to karma if

0:41:36.680 --> 0:41:39.440
<v Speaker 1>you also expand the definition of karma to include the

0:41:39.520 --> 0:41:42.560
<v Speaker 1>law of karma. But he says it was a good

0:41:42.560 --> 0:41:44.520
<v Speaker 1>podcast overall, you guys really hit it on the head

0:41:44.560 --> 0:41:46.799
<v Speaker 1>except for these peop points. He did not hit it

0:41:46.840 --> 0:41:48.560
<v Speaker 1>on the head cover that No, well, just for that

0:41:48.600 --> 0:41:52.279
<v Speaker 1>one part. And finally he pointed out, and a few

0:41:52.280 --> 0:41:54.680
<v Speaker 1>other people pointed out that I was wrong in correcting

0:41:54.680 --> 0:41:58.440
<v Speaker 1>you with Jainism and ye's jaine is Um. Thank you,

0:41:58.960 --> 0:42:05.560
<v Speaker 1>but gonna play you something right now? Okay, okay, that

0:42:05.719 --> 0:42:09.680
<v Speaker 1>was from dictionary dot com. Well that that voice is

0:42:09.680 --> 0:42:14.640
<v Speaker 1>obviously wrong. Maybe so this is from Mariam Webster. If

0:42:14.640 --> 0:42:18.799
<v Speaker 1>it's the same voice, it doesn't count twice did you

0:42:18.800 --> 0:42:21.000
<v Speaker 1>hear that that's a different voice? Did that one come

0:42:21.040 --> 0:42:26.120
<v Speaker 1>through Matt? Okay? And then finally, this is Google definitions

0:42:26.160 --> 0:42:28.680
<v Speaker 1>and this is my favorite of all. Actually I don't

0:42:28.719 --> 0:42:33.759
<v Speaker 1>like for this. Wow, So I don't know because I

0:42:33.800 --> 0:42:38.200
<v Speaker 1>had like three other people said no, many other robots, no,

0:42:38.360 --> 0:42:40.480
<v Speaker 1>three other real people said no, it's jain is um.

0:42:40.800 --> 0:42:42.520
<v Speaker 1>And then I went on YouTube and people said jain

0:42:42.600 --> 0:42:45.920
<v Speaker 1>is um. So I don't know. Well, I like that

0:42:46.000 --> 0:42:49.879
<v Speaker 1>it's both we're both right, yea, or we're both wrong. Yeah, yeah,

0:42:50.000 --> 0:42:53.400
<v Speaker 1>it was genis um. Well, we love corrections so much

0:42:53.440 --> 0:42:56.480
<v Speaker 1>that I managed to forget that we or are corrected

0:42:56.520 --> 0:42:58.359
<v Speaker 1>a lot, or we used to read them. I never

0:42:58.400 --> 0:43:02.920
<v Speaker 1>forget that we're corrected. Um, but let's do this again soon. Agree,

0:43:03.800 --> 0:43:08.560
<v Speaker 1>Go through all fifty episodes, find everything you can that's

0:43:08.560 --> 0:43:12.440
<v Speaker 1>wrong with them, and then let us know. Okay, okay

0:43:12.600 --> 0:43:14.840
<v Speaker 1>or you can just correct the most recent ones whatever

0:43:14.840 --> 0:43:18.200
<v Speaker 1>we got wrong in this one, which I'm sure is substantial. Um.

0:43:18.280 --> 0:43:20.640
<v Speaker 1>You can go on Facebook if you want. You can

0:43:20.640 --> 0:43:23.799
<v Speaker 1>tweet to us s y s K podcast, or you

0:43:23.800 --> 0:43:26.560
<v Speaker 1>can send us a plain old fashion email at stuff

0:43:26.600 --> 0:43:34.000
<v Speaker 1>podcast at how stuff works dot com for more on

0:43:34.080 --> 0:43:36.560
<v Speaker 1>this and thousands of other topics, does it how stuff

0:43:36.560 --> 0:43:40.120
<v Speaker 1>works dot com. Want more how stuff works, check out

0:43:40.120 --> 0:43:42.359
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0:43:42.400 --> 0:43:43.680
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