WEBVTT - The Daily Dive: What I Learned About My Health From Exploring My DNA 0:00:03.279 --> 0:00:06.560 Have you ever thought about how incredibly complex I spit is. 0:00:07.240 --> 0:00:11.280 It may only be water, but just aliva isn't simple. 0:00:11.800 --> 0:00:17.440 That remaining one holds incredibly meaningful information that could change everything. 0:00:17.720 --> 0:00:21.279 And I'm not just talking about your family treat Hi. 0:00:21.520 --> 0:00:24.360 I'm barretton Day Thurston and on this season of Spit 0:00:24.520 --> 0:00:26.720 and I Heart Radio podcast with twenty three and Me, 0:00:27.280 --> 0:00:30.960 we explore how DNA isn't just about ancestry, it can 0:00:31.000 --> 0:00:39.160 also be key to understanding your health. Hi again, We're bad. 0:00:40.120 --> 0:00:44.720 Oscar Ramirez, host of The Daily Dive, is all about 0:00:44.840 --> 0:00:48.839 the facts. Each day, his podcast explores the most interesting 0:00:48.880 --> 0:00:51.240 news of the day with the writers, the analysts of 0:00:51.280 --> 0:00:54.840 reporters who know the real story. So when Oscar took 0:00:54.920 --> 0:00:58.160 his twenty three and Me test, you know he had questions. 0:00:58.960 --> 0:01:01.960 In this episode, Oscar sits down with twenty three and 0:01:02.080 --> 0:01:05.560 Me's Stacy Dettweiler and the Lisa Layman to get to 0:01:05.600 --> 0:01:08.680 the bottom of his test results. As an Hispanic man, 0:01:08.920 --> 0:01:12.240 diabetes in high blood pressure run in his family. So 0:01:12.280 --> 0:01:14.360 what can his twenty three and me results to Oscar 0:01:14.400 --> 0:01:18.840 about his own health. It's a fascinating conversation and the 0:01:19.080 --> 0:01:23.000 must listen for anyone interested in unlocking the knowledge contained 0:01:23.000 --> 0:01:26.480 in their own DNA. Oscar takes a deep dive into 0:01:26.520 --> 0:01:29.120 his variance and tries to get to the bottom of 0:01:29.160 --> 0:01:32.880 some things that just don't add up. For example, Oscar 0:01:33.040 --> 0:01:36.880 loves cilantro, but according to his test results, he's supposed 0:01:36.880 --> 0:01:41.080 to hate it. So what's going on. Let's listen in 0:01:41.200 --> 0:01:44.000 and learn more about the awesome power of DNA when 0:01:44.000 --> 0:01:50.720 it comes to understanding your health. I'm Oscar Emiress and 0:01:50.800 --> 0:01:58.560 this is the Daily Dive. This episode is something special 0:01:58.600 --> 0:02:01.560 I did in conjunction with me in the Spit podcast, 0:02:01.640 --> 0:02:03.680 which you can hear and I heart Radio. I took 0:02:03.680 --> 0:02:06.480 a look into what my DNA says about me, beyond 0:02:06.520 --> 0:02:09.160 what my ancestry says and with a focus on my health. 0:02:09.800 --> 0:02:12.239 Throughout this process, I learned about two genetic variants that 0:02:12.280 --> 0:02:15.200 could impact myself for my family, and also that I 0:02:15.200 --> 0:02:18.280 have a typical likelihood of developing type two diabetes, which 0:02:18.320 --> 0:02:20.320 has always been a concern since it runs in my family. 0:02:21.040 --> 0:02:23.080 There is also some fun stuff I learned about my 0:02:23.160 --> 0:02:25.640 d N a I won't be losing my hair anytime soon, 0:02:26.000 --> 0:02:30.560 and why I experienced itchyr mosquito bites. Stacy Dettweiler and 0:02:30.600 --> 0:02:32.480 at Lisa Lehman from the twenty three and Me team 0:02:32.520 --> 0:02:34.480 both joined me to go over some of my results 0:02:34.680 --> 0:02:38.440 and help me understand more about my DNA. Next, I 0:02:38.480 --> 0:02:40.280 go a little deeper into what the results I got 0:02:40.320 --> 0:02:43.440 specifically mean to me, things I've experienced with my family 0:02:43.480 --> 0:02:45.720 and in my past, and why this process has been 0:02:45.720 --> 0:02:48.200 eye opening. In some cases, the best thing to come 0:02:48.200 --> 0:02:50.640 out of this has been the information learned and knowing 0:02:50.680 --> 0:02:53.480 what to do next to improve my health. It's news 0:02:53.480 --> 0:02:57.400 without the noise. Let's dive in the good thing is 0:02:57.440 --> 0:02:59.840 for you. It sounds like there was just one variant identified, 0:03:00.040 --> 0:03:02.280 and something that's really interesting is these variants are actually 0:03:02.480 --> 0:03:05.880 very common, and so a lot of people are walking 0:03:05.880 --> 0:03:08.520 around with these variants, and so really just having one 0:03:08.600 --> 0:03:11.760 variant doesn't increase your risk compared to the general population 0:03:11.800 --> 0:03:14.120 because most people do have these variants. Joining us now 0:03:14.200 --> 0:03:17.600 is Stacy Dettweiler, a genetic counselor and manager on the 0:03:17.639 --> 0:03:20.239 Medical Affairs team at twenty three and Me, and the 0:03:20.320 --> 0:03:23.800 Lisa Lehman, a senior manager on the product science team 0:03:24.040 --> 0:03:25.960 at twenty three and Me. Thank you for joining me, ladies, 0:03:26.600 --> 0:03:29.320 Thank you all, Thanks for having us. All right, So 0:03:29.520 --> 0:03:32.600 this whole thing special episode of The Daily Dive done 0:03:32.639 --> 0:03:35.160 in partnership with twenty three and Me and the Spit podcast. 0:03:35.200 --> 0:03:37.760 You can hear that on I Heart Radio. Uh I, 0:03:37.880 --> 0:03:40.200 this was the first time doing one of these DNA 0:03:40.320 --> 0:03:42.840 test genetic tests and all that. It was a lot 0:03:42.880 --> 0:03:44.800 of fun. You know, you sign up on the app, 0:03:44.840 --> 0:03:47.200 you spitting a little tube, send it off, get a 0:03:47.200 --> 0:03:50.880 bunch of results. For this we're specifically focusing on what 0:03:51.200 --> 0:03:54.040 your DNA, what your genes can tell you about your 0:03:54.080 --> 0:03:58.520 health things, diseases, illnesses, things that you can be predisposed 0:03:58.520 --> 0:04:01.560 to because of your genet X and uh you know, 0:04:01.800 --> 0:04:03.640 going into it, you kind of have this little worry 0:04:03.720 --> 0:04:05.000 you know what am I going to be flagged for? 0:04:05.200 --> 0:04:09.240 What's going to happen? Even as you opt into certain 0:04:09.280 --> 0:04:12.520 reports it tells you, like for Alzheimer's, you know, you know, 0:04:12.600 --> 0:04:14.640 be very conscious of what you're gonna get into on 0:04:14.680 --> 0:04:18.320 this because it could be unnerving what you get. Uh 0:04:18.360 --> 0:04:20.560 So I I kind of experienced all that stuff going 0:04:20.560 --> 0:04:22.680 into this, so I opted into for all of that. 0:04:22.720 --> 0:04:25.440 I wanted to know what, uh my genes, my DNA 0:04:25.480 --> 0:04:28.479 could tell me as much as possible and Thankfully, it 0:04:28.520 --> 0:04:30.000 came back with just a few things. Some of the 0:04:30.000 --> 0:04:32.000 scary things, right, a lot of people are concerned with 0:04:32.040 --> 0:04:35.080 their health didn't come through. But I was flagged for 0:04:35.160 --> 0:04:39.200 two variants for certain things and likelihood for developing type 0:04:39.200 --> 0:04:41.159 two diabetes. So we'll get into all of this right now. 0:04:41.120 --> 0:04:42.520 I want to bring you, ladies on to talk about 0:04:42.560 --> 0:04:45.000 the science of how this stuff works. The first thing 0:04:45.040 --> 0:04:48.520 I was flagged for was age related macular degeneration. So 0:04:48.560 --> 0:04:50.719 this is uh, one of the most common causes of 0:04:50.800 --> 0:04:54.680 irreversible vision losses. Happens in older adults. Usually I have 0:04:55.200 --> 0:04:58.640 one variant. It's the A six nine S variant in 0:04:58.720 --> 0:05:02.320 the A r M two gene. So very little complicated 0:05:02.360 --> 0:05:03.880 right now. But a lot of people don't really have 0:05:04.000 --> 0:05:06.760 a basis for understanding some of these things. So ladies, 0:05:06.760 --> 0:05:09.160 if you can help me explain, help explain what does 0:05:09.279 --> 0:05:12.479 this mean in particular. You know, I think the main 0:05:12.640 --> 0:05:16.120 aspect is genetics is part of the story, right, and 0:05:16.160 --> 0:05:19.160 so for this condition, usually macularity generation, I'm going to 0:05:19.279 --> 0:05:22.400 say a m D for short. Um, we know that 0:05:22.440 --> 0:05:25.920 there are some genetic variants that do increase your risk 0:05:26.040 --> 0:05:29.120 of developing this, right, But luckily there's a lot of 0:05:29.120 --> 0:05:31.960 other factors that play a role. Lifestyle smoking is a 0:05:32.000 --> 0:05:34.799 big one, right, So there's a lot of action ability 0:05:34.920 --> 0:05:38.800 within these results that you can do to reduce your chances. 0:05:39.200 --> 0:05:40.720 The good thing is for you, it sounds like there 0:05:40.800 --> 0:05:43.600 was just one variant identified. And something that's really interesting 0:05:43.680 --> 0:05:47.120 is these variants are actually very common, and so a 0:05:47.160 --> 0:05:49.839 lot of people are walking around with these variants and 0:05:49.839 --> 0:05:52.440 so really just having one variant doesn't increase your risk 0:05:52.480 --> 0:05:55.240 compared to the general population because most people do have 0:05:55.320 --> 0:05:58.840 these variants. UM. It's when you start getting multiple that's 0:05:58.839 --> 0:06:01.919 when that risk can really increase. Yeah, and when you 0:06:01.920 --> 0:06:05.559 get to results through the app or on your online it, 0:06:05.560 --> 0:06:07.919 it did tell me that I'm not at a particularly 0:06:07.920 --> 0:06:10.920 likelihood for developing this UM. But you know, obviously one 0:06:10.920 --> 0:06:12.520 of the things that happens is the vision loss, and 0:06:12.560 --> 0:06:16.320 this figures into kind of my personal overall story. There's 0:06:16.360 --> 0:06:19.359 a lot of themes running with vision, whether it be 0:06:19.440 --> 0:06:22.160 through diabetes and other things. So I open it right, 0:06:22.200 --> 0:06:24.279 and a lot of this we're using these things to 0:06:24.320 --> 0:06:27.520 kind of empower ourselves to learn more about ourselves. You know. 0:06:27.560 --> 0:06:29.200 I know a lot of people don't obviously go to 0:06:29.240 --> 0:06:31.360 the doctor all the time, and you know, you go 0:06:31.440 --> 0:06:34.279 when something's wrong and you don't really know what's happening 0:06:34.440 --> 0:06:37.000 in your body until it's too late. Sometimes I have 0:06:37.040 --> 0:06:39.920 to admit I'm kind of guilty of that myself. And 0:06:40.320 --> 0:06:42.280 so these things are eye opening. So as we kind 0:06:42.279 --> 0:06:44.120 of go through, I'll connect the dots on some of 0:06:44.160 --> 0:06:46.359 these things. Another one that I was flagged for, So 0:06:46.400 --> 0:06:50.599 this is hereditary emo chromatosis. Basically it's something that could 0:06:50.640 --> 0:06:54.680 lead to iron overload. Again, it flagged me for one 0:06:54.720 --> 0:06:57.520 of these genes. It said that I'm not at particular 0:06:57.760 --> 0:07:00.240 risk for this, but still this is another They're one 0:07:00.279 --> 0:07:03.760 of those genes that I carry around. Yeah, and it's 0:07:03.760 --> 0:07:06.640 probably again another one that you've never heard of before, 0:07:06.640 --> 0:07:08.839 you twenty three and me. And that's very common for 0:07:08.880 --> 0:07:11.760 a lot of these genetic conditions that have it where 0:07:11.840 --> 0:07:14.760 you know, it's one gene that can really be impacted 0:07:14.800 --> 0:07:18.040 that can cause these conditions. Um, and this one is 0:07:18.360 --> 0:07:21.680 kind of more considered an autosomal recessive and so having 0:07:21.760 --> 0:07:24.040 just one variant, we typically think of you as being 0:07:24.120 --> 0:07:27.680 a carrier. You carry a variant, but you really don't 0:07:27.880 --> 0:07:31.840 have the condition in terms of expressing symptoms unless you 0:07:31.960 --> 0:07:34.760 have kind of a combination two copies of a of 0:07:34.800 --> 0:07:37.840 a particular variant. And the interesting thing with this condition 0:07:37.880 --> 0:07:41.520 too is that again genetics is still not the full story. 0:07:41.600 --> 0:07:44.400 There's a lot of people that have two copies of 0:07:44.400 --> 0:07:46.920 a variant or two different variants um and they don't 0:07:46.920 --> 0:07:50.119 still develop the iron overloads. So there's you know, again, 0:07:50.200 --> 0:07:53.720 genetics is a huge aspect of it when we're talking 0:07:53.760 --> 0:07:56.520 about health, but there's a lot of other things that 0:07:56.560 --> 0:08:00.160 go along to like lifestyle that can play a big all. 0:08:00.200 --> 0:08:02.760 But I think the main thing for you is, you know, 0:08:02.760 --> 0:08:05.960 it might not be an indication for concern for your help, 0:08:06.280 --> 0:08:09.640 but it could be for family members or your offspring, 0:08:09.640 --> 0:08:12.040 because that's when you can actually have that chance. That's 0:08:12.080 --> 0:08:14.960 exactly That's exactly my next point right there. So when 0:08:14.960 --> 0:08:17.400 you read some of these reports either on the app 0:08:17.560 --> 0:08:20.600 or or online and everything, they're very detailed, very thorough, 0:08:21.320 --> 0:08:24.480 really help you kind of navigate what the the information 0:08:24.480 --> 0:08:26.520 that you're being given, right, it will help you on 0:08:26.560 --> 0:08:29.640 the other end of things, let's create a health plan. 0:08:29.960 --> 0:08:32.440 So I very much appreciate that, but it did say, 0:08:32.520 --> 0:08:34.560 you know, it says in that there's a concern right 0:08:34.760 --> 0:08:37.079 that you can pass this variant onto your children. So 0:08:37.400 --> 0:08:39.280 if my wife has one of the other variants, then 0:08:39.320 --> 0:08:41.600 these things started kind of start compounding on each other. 0:08:42.040 --> 0:08:43.800 Um So it feels like, now I need to have 0:08:43.840 --> 0:08:46.640 my wife take one of these DNA tests just so 0:08:46.720 --> 0:08:49.280 we can start checking all this stuff out and then 0:08:49.320 --> 0:08:51.920 some of the signs and symptoms of iron overload, not 0:08:52.000 --> 0:08:55.960 that I have it or will develop it, but heart disease, diabetes, 0:08:56.240 --> 0:08:58.480 these are things that run in my family. So now 0:08:58.559 --> 0:09:01.600 to the big one, the diabetes. With this DNA test, 0:09:01.679 --> 0:09:05.000 it said I have a typical likelihood of developing type 0:09:05.000 --> 0:09:07.800 two diabetes. To your point, Stacy, right, you've been making 0:09:07.800 --> 0:09:09.960 the point that there's a lot of other factors that 0:09:10.040 --> 0:09:12.200 weigh in on this. It's not just your genetics. It 0:09:12.320 --> 0:09:15.040 is your lifestyle. And you know, we know people that 0:09:15.120 --> 0:09:19.160 are overweight, unhealthy lifestyle. You can turn around diabetes in 0:09:19.160 --> 0:09:22.000 a lot of cases when you adjust that lifestyle. But 0:09:22.440 --> 0:09:24.400 I was talking to my mom for some of this stuff, 0:09:24.400 --> 0:09:26.400 and she's like, man, some of this stuff is depressing 0:09:26.400 --> 0:09:28.440 to kind of go through because this does run in 0:09:28.480 --> 0:09:32.199 my family all over the place, on both sides. My grandpa, 0:09:32.360 --> 0:09:36.240 his brothers and sisters, my grandma, my mom has pre diabetes. 0:09:37.000 --> 0:09:40.439 My sister had gestational diabetes and it went away after 0:09:40.480 --> 0:09:43.120 the kids came. And uh, you know, on my dad's side, 0:09:43.160 --> 0:09:45.640 high blood pressure, all of this stuff. But on this one, 0:09:45.679 --> 0:09:49.280 it tells me, uh, you know, I'm Latino, my family 0:09:49.320 --> 0:09:52.319 mostly comes from Mexico. My genetics say, I'm an estimated 0:09:52.360 --> 0:09:57.120 fort chance of developing type two diabetes. Yeah. So, Lisa, 0:09:57.120 --> 0:09:59.120 do you want to talk a little bit about how 0:09:59.240 --> 0:10:02.040 this report differs compared to the other ones and the 0:10:02.360 --> 0:10:06.319 science behind it. Yeah. So for the other two continents 0:10:06.360 --> 0:10:07.920 that you were talking about, right, it was really about 0:10:07.920 --> 0:10:09.880 that like the one variant where you have this one 0:10:09.960 --> 0:10:12.840 variant UM, and again if you had a combination of 0:10:12.840 --> 0:10:15.040 a couple of these variants, that would you know, increase 0:10:15.080 --> 0:10:18.000 your your likelihood of developing those conditions. But as you know, 0:10:18.040 --> 0:10:20.760 type two diabetes it's really common. And actually there's not 0:10:20.920 --> 0:10:24.439 just one variant or one gene that's involved in UM 0:10:24.559 --> 0:10:27.760 potentially developing this condition. So for this report, what we 0:10:27.840 --> 0:10:31.320 look at is actually over a thousand different places in 0:10:31.360 --> 0:10:34.520 your in your DNA, and we add up the effect 0:10:34.640 --> 0:10:37.120 of all of those different places UM to give you 0:10:37.120 --> 0:10:40.120 that sort of score, that percent chance of developing type 0:10:40.160 --> 0:10:42.520 of diabetes. And in your case, we're saying you have 0:10:42.600 --> 0:10:45.360 like this typical likelihood, but as you noted, that typical 0:10:45.400 --> 0:10:48.400 likelihood is still pretty high, you know, chance is still 0:10:48.600 --> 0:10:51.800 a pretty high chance of developing um T t D. 0:10:52.320 --> 0:10:54.640 But again, there's all those other factors that Stacy was 0:10:54.679 --> 0:10:57.880 talking about, you know, your way to your lifestyle, your diet, 0:10:57.960 --> 0:11:00.319 your family history. All of that goes into whether you 0:11:00.360 --> 0:11:03.600 actually go on to develop diabetes. So there's definitely other 0:11:03.600 --> 0:11:08.120 things you can do besides just knowing about your genetics. Yeah, definitely. 0:11:08.120 --> 0:11:10.160 And you know, in my own personal health, right, I 0:11:10.520 --> 0:11:12.440 used to be a lot heavier when I was younger. 0:11:13.000 --> 0:11:15.640 More recently I began to lose a little bit of weight, 0:11:15.679 --> 0:11:18.000 and but you look at some of these symptoms that 0:11:18.080 --> 0:11:21.360 you can get, you know, increased thirst, frequent urination, fatigue, 0:11:21.360 --> 0:11:24.360 blurred vision again one of these other common things that 0:11:24.480 --> 0:11:28.160 I've noticed, Right, I feel like I remember having some 0:11:28.200 --> 0:11:30.240 of these things maybe and then going away a little 0:11:30.280 --> 0:11:32.679 bit once I lost some weight. Uh. You know, I'll 0:11:32.679 --> 0:11:34.920 get a little bit into more personal details of this, 0:11:35.120 --> 0:11:37.120 uh in the next segment when I continue to talk 0:11:37.160 --> 0:11:39.959 about all this. But it's it's interesting and it's one 0:11:40.000 --> 0:11:41.760 of the things that affects a lot of people in 0:11:41.760 --> 0:11:45.920 the country. Across the general US population around people are 0:11:45.960 --> 0:11:48.800 expected to develop type two diabetes during their lifetime. It's 0:11:49.040 --> 0:11:51.360 it's a big thing, and it impacts people's health in 0:11:51.360 --> 0:11:53.520 in so many ways. So it's important to kind of 0:11:53.559 --> 0:11:56.600 know these things and start looking into your own health 0:11:56.640 --> 0:11:59.920 to to hopefully mitigate some of these things. And and 0:12:00.080 --> 0:12:03.559 I'm very appreciative of this whole process because sometimes a 0:12:03.600 --> 0:12:05.480 lot of people put their health on the back burner 0:12:05.920 --> 0:12:08.640 and these things kind of open your eyes. And again 0:12:08.679 --> 0:12:10.559 to the credit of twenty three me and the apps 0:12:10.559 --> 0:12:13.000 and everything, it really helps you with the follow through. 0:12:13.040 --> 0:12:15.520 Why don't you speak to a doctor that will give 0:12:15.520 --> 0:12:17.640 you tips and tricks on what to help with all 0:12:17.679 --> 0:12:20.400 of it. So, uh, it's it has been eye opening 0:12:20.720 --> 0:12:22.800 for me and conversations I've had with my mom, like 0:12:22.840 --> 0:12:25.720 I said, and just looking at my own personal health. Um, 0:12:25.760 --> 0:12:29.079 so I appreciate that and it's you know, it's making 0:12:29.120 --> 0:12:33.000 me want to to really start changing things again in 0:12:33.000 --> 0:12:38.080 my lifestyle. Thank you for walking me through some of this. 0:12:38.120 --> 0:12:40.319 Is there are important things I didn't want to talk about, 0:12:40.360 --> 0:12:43.360 some fun things as well that you get to look at. 0:12:43.559 --> 0:12:46.120 There's so many things in here. One of the main 0:12:46.120 --> 0:12:47.839 things I tell people when I did the twenty three 0:12:47.840 --> 0:12:51.440 and me thing, everybody starts talking about Neanderthal DNA right away, 0:12:51.800 --> 0:12:54.480 and so what's with the neanderthal dna? It told me 0:12:55.040 --> 0:12:59.680 I have more Neanderthal DNA than of other twenty three 0:12:59.679 --> 0:13:01.960 and me customers. I think it's about two percent of 0:13:02.040 --> 0:13:04.960 my total DNA. But man, I feel like a caveman 0:13:05.000 --> 0:13:07.960 after that. Definitely don't feel like a caveman. I think, 0:13:08.080 --> 0:13:11.120 UM hopefully that's one of the things that comes across 0:13:11.160 --> 0:13:13.640 the in that report is actually, you know, we all 0:13:13.640 --> 0:13:17.000 share a little bit of me anitholo DNA, so UM 0:13:17.040 --> 0:13:20.800 some history about that. UM scientists not at three and 0:13:21.240 --> 0:13:24.800 UM actually sequenced in the ornitholo genome and so when 0:13:24.840 --> 0:13:26.800 they did that, you can compare that to you know, 0:13:26.880 --> 0:13:29.600 the human genome, and you can say, oh, look there's 0:13:29.679 --> 0:13:32.560 overlap here. So some of our ancestors were, you know, 0:13:32.760 --> 0:13:36.079 enjoying each other back, you know, fifty plus years ago. 0:13:37.360 --> 0:13:39.840 As we spread across the across the globe, and our 0:13:39.920 --> 0:13:43.360 DNA sort of carries that signature UM in all of us, 0:13:43.880 --> 0:13:46.640 and so it tells us that that DNA can influence 0:13:46.679 --> 0:13:49.080 certain traits and I look through and some of these 0:13:49.160 --> 0:13:51.560 things were like spot on. It tells me I have 0:13:51.600 --> 0:13:55.400 a variant associated with experiencing more itchy mosquito bites and 0:13:55.480 --> 0:13:58.199 that man, I hate that I get bit up more 0:13:58.240 --> 0:14:00.320 than the other people I'm around, and then I am 0:14:00.360 --> 0:14:04.040 like constantly scratching. You know, it's like the itch goes 0:14:04.080 --> 0:14:05.760 away and you don't want to touch you more for 0:14:05.800 --> 0:14:09.240 fear of activating the itch all over again. Um, I 0:14:09.280 --> 0:14:11.960 have two variants associated with being less likely to have 0:14:11.960 --> 0:14:14.920 a fear of heights. Totally true. I am unafraid of that. 0:14:15.440 --> 0:14:17.200 This one is a little iffy. It told me I 0:14:17.200 --> 0:14:19.440 could be a better sprinter than a distance runner. I'm 0:14:19.440 --> 0:14:21.960 not sure how how much that one pans out, but 0:14:22.200 --> 0:14:25.440 apparently these things come from from that side of our 0:14:25.520 --> 0:14:30.600 DNA at least. Yeah, Well we've what twas found looking 0:14:30.640 --> 0:14:33.640 at that portion of Neanderthal DNA is we can find 0:14:33.640 --> 0:14:36.840 those associations. So between a trait um like you know, 0:14:37.120 --> 0:14:40.600 each mosquito bites, and that's the specific genetic variance that 0:14:40.600 --> 0:14:42.480 came from our nan and Paul ancestors. So that's what 0:14:42.960 --> 0:14:44.720 you know. That part of the report is telling you, 0:14:44.680 --> 0:14:48.080 you know, where did you inherit? Thatsquito bite from. Some 0:14:48.160 --> 0:14:50.200 of the physical traits that were also fun. You know, 0:14:50.240 --> 0:14:53.480 we all have our things that we're concerned about, our looks, 0:14:53.480 --> 0:14:56.120 our appearances. Uh. These ones, I was very happy to 0:14:56.120 --> 0:14:59.480 see bald spot and early hair loss. I'm not likely 0:14:59.520 --> 0:15:02.000 to develop that stuff. My dad had a great head 0:15:02.000 --> 0:15:05.200 of hair. Although gray's gray hairs are like crazy and 0:15:05.240 --> 0:15:08.320 they're coming up on me and my beard and everything. Um. 0:15:08.360 --> 0:15:10.400 I didn't want to talk about some of the things 0:15:10.400 --> 0:15:12.680 that don't add up though, because I think a lot 0:15:12.720 --> 0:15:16.440 of people look at these ancestry reports, these DNA reports 0:15:16.440 --> 0:15:18.480 and all that, and they say, well, this doesn't match up. 0:15:18.680 --> 0:15:20.440 So if you could help explain why some of that 0:15:20.480 --> 0:15:22.720 doesn't come through. Some of these things that didn't add 0:15:22.800 --> 0:15:24.960 up for me. Where says I'm not likely to be 0:15:25.000 --> 0:15:27.720 an especially deep sleeper. I sleep like a rock. I 0:15:27.760 --> 0:15:29.520 get in there and fall asleep right away, and I 0:15:29.520 --> 0:15:32.200 fall asleep. And uh, the last one, the main one 0:15:32.200 --> 0:15:34.360 I think for me, was it says I'm slightly higher 0:15:34.400 --> 0:15:37.840 odds of disliking cilantro. A lot of people say it's 0:15:37.840 --> 0:15:41.120 associated with like a soapy taste. That one is not 0:15:41.200 --> 0:15:44.520 me either. I love Cilantro, So how come some of 0:15:44.600 --> 0:15:47.400 these don't match up? Sometimes we'll take Cilantro as as 0:15:47.440 --> 0:15:50.440 the example. I think, Um, you know, one thing is 0:15:50.640 --> 0:15:53.080 your DNA might nudge you in one direction or the other. 0:15:53.160 --> 0:15:55.480 So right in your case, it's saying, oh, you're you're 0:15:55.560 --> 0:15:57.880 more likely than the average person or the average ty 0:15:57.960 --> 0:16:01.280 three and the research participant um to dislike Cilantro. If 0:16:01.280 --> 0:16:02.960 you dig a little bit deeper into the report, we 0:16:03.000 --> 0:16:05.920 tell you, you you know only about people tell us that 0:16:05.920 --> 0:16:08.120 they dislike Cilantro. So you being a little bit more 0:16:08.160 --> 0:16:10.840 likely doesn't mean that you have a hundred percent chance 0:16:10.920 --> 0:16:13.520 of disliking Cilantro. Right, So you might just be in 0:16:13.560 --> 0:16:16.160 that in that other um, you know, chunk of people 0:16:16.240 --> 0:16:20.040 who like Cilantro but have that same genetic background. So again, 0:16:20.240 --> 0:16:22.120 you know, there's there's culture, there's the food that you 0:16:22.160 --> 0:16:25.560 eat growing up. There's probably other parts of your taste 0:16:25.560 --> 0:16:28.800 and smell that that influenced this. But that you know, 0:16:28.840 --> 0:16:31.440 the one variant that we found, you know that did 0:16:31.520 --> 0:16:34.480 you a little bit um in the dislike. And that's 0:16:34.480 --> 0:16:37.280 so true. Uh, in my diet growing up, you know, 0:16:37.320 --> 0:16:39.240 I grew up in a Mexican household, a lot of 0:16:39.280 --> 0:16:41.880 GUACAMOLEI a lot of other things. We put it in everything, 0:16:41.920 --> 0:16:44.880 so probably I just developed the taste for it and 0:16:44.920 --> 0:16:47.880 just never turned back. A lot, a lot of fun stuff, 0:16:47.880 --> 0:16:51.080 a lot of information. Again, going through this process has 0:16:51.080 --> 0:16:53.360 been eye opening in a lot of ways on the 0:16:53.400 --> 0:16:55.360 health side of things, on some of this fun stuff 0:16:55.400 --> 0:16:57.360 that just kind of you know, I sat back and 0:16:57.400 --> 0:16:59.480 got my results and I was clicking through that for 0:16:59.560 --> 0:17:01.680 like an hour. You know, you just kind of keep going. 0:17:01.760 --> 0:17:04.639 There's so many reports and updated surveys and things that 0:17:04.720 --> 0:17:07.679 you can participate in. It kind of keep that information rolling. 0:17:07.680 --> 0:17:09.919 So I appreciate all of that, and thank you to 0:17:09.960 --> 0:17:11.840 you ladies as well for joining me and helping me 0:17:11.920 --> 0:17:16.240 walk through my results. Stacy debt Wiler, genetic counselor and 0:17:16.320 --> 0:17:19.720 manager at the Medical Affairs Team A Lisa Lehman, senior 0:17:19.760 --> 0:17:22.280 manager on the Product science team at ME. Thank you 0:17:22.320 --> 0:17:29.359 both for joining me. Thank you, thank you for this report. 0:17:29.400 --> 0:17:32.480 What we look at is actually over a thousand different 0:17:32.520 --> 0:17:35.879 places in your in your DNA, and we add up 0:17:35.920 --> 0:17:38.639 the effect of all of those different places um to 0:17:38.720 --> 0:17:41.280 give you that sort of score, that percent chance of 0:17:41.280 --> 0:17:43.520 developing type of diabetes. For this segment, I wanted to 0:17:43.560 --> 0:17:47.080 delve a little bit more into my personal health. I 0:17:47.119 --> 0:17:50.360 wanted to connect the dots for my results. I wanted 0:17:50.359 --> 0:17:52.000 to talk a little bit about what it means to 0:17:52.080 --> 0:17:55.080 me and what it means for my health. You know, 0:17:55.160 --> 0:17:57.800 the whole point of this is to get more knowledge, 0:17:58.160 --> 0:18:01.160 to know what our DNA says about us, and then 0:18:01.280 --> 0:18:04.920 use that knowledge to to act on things to protect 0:18:04.920 --> 0:18:07.280 our health, to make the right steps in our lives 0:18:07.280 --> 0:18:09.560 to make sure that we're as healthy as long as 0:18:09.560 --> 0:18:11.879 we can be. And thank you to the folks at 0:18:11.920 --> 0:18:14.320 twenty three and me for going over my results in 0:18:14.359 --> 0:18:17.359 the previous segment. But just as far as these two 0:18:17.560 --> 0:18:20.200 variants are concerned, these two variant genes that I have 0:18:20.600 --> 0:18:24.000 and the typical likelihood of developing type two diabetes, this 0:18:24.040 --> 0:18:26.159 really speaks to me for in a lot of different ways. 0:18:26.680 --> 0:18:30.119 So connecting the dots age related macular degeneration deals with 0:18:30.240 --> 0:18:35.520 vision loss. Hereditary hemochromatosis can lead to diabetes, and then 0:18:35.520 --> 0:18:38.600 type two diabetes is in extreme complications, you can develop 0:18:39.119 --> 0:18:43.160 vision loss, heart disease, kidney damage, and so this theme 0:18:43.200 --> 0:18:46.800 of vision loss has been something that I've been thinking 0:18:46.800 --> 0:18:49.560 a lot about through this process. Now, to be clear, 0:18:49.640 --> 0:18:52.679 my results aren't diagnosing me with anything specific or I 0:18:52.680 --> 0:18:55.679 am not at a particularly higher risk of developing some 0:18:55.760 --> 0:18:57.760 of those things. But it gets you thinking about your 0:18:57.760 --> 0:19:01.240 health and that's what's important here. Sharing personal story. When 0:19:01.320 --> 0:19:03.920 I was much younger, I was out with some friends 0:19:03.960 --> 0:19:07.000 and we were assaulted. Somebody hit me on the side 0:19:07.000 --> 0:19:09.600 of the head with with a broomstick. I had to 0:19:09.640 --> 0:19:13.119 go to the emergency room and what happened after that 0:19:13.320 --> 0:19:16.320 was a detachment of my iris. If you look very 0:19:16.320 --> 0:19:20.240 closely into my eye, you can see it. Since then, uh, 0:19:20.280 --> 0:19:22.280 you know, I've had experienced a little bit of vision 0:19:22.320 --> 0:19:24.879 loss in that I I have developed a cataract. In 0:19:24.960 --> 0:19:27.560 that I there will be things down the road that 0:19:27.600 --> 0:19:30.600 I will need to take care of my vision. This 0:19:30.680 --> 0:19:33.080 is specifically in my right eye. My left eye, I 0:19:33.119 --> 0:19:37.200 wear glasses normally. My left eye is experiencing normal vision. 0:19:37.240 --> 0:19:39.560 I still need the glasses to see better, but this 0:19:39.640 --> 0:19:41.720 is something that I really do need to take care 0:19:41.760 --> 0:19:43.679 of in my life. I need to make sure that 0:19:43.760 --> 0:19:47.560 I can keep my vision intact as much as possible. 0:19:48.160 --> 0:19:50.840 So going through some of these results and seeing what 0:19:50.880 --> 0:19:54.000 these variant genes can do and the typical likelihood of 0:19:54.160 --> 0:19:57.920 diabetes type two diabetes. It makes you think, It makes 0:19:57.960 --> 0:20:01.119 you think of the future, makes you think of your 0:20:01.160 --> 0:20:04.040