1 00:00:01,480 --> 00:00:04,280 Speaker 1: Welcome to Stuff you Should Know, a production of I 2 00:00:04,360 --> 00:00:13,320 Speaker 1: Heart Radio. Hey, and welcome to the podcast. I'm Josh 3 00:00:13,360 --> 00:00:16,000 Speaker 1: Clark and there's Charles w Chuck Brian over there, and 4 00:00:16,040 --> 00:00:18,680 Speaker 1: it's just the two of us who were flying solo. 5 00:00:19,720 --> 00:00:23,000 Speaker 1: Um and that's okay, we're gonna do this and this 6 00:00:23,079 --> 00:00:25,919 Speaker 1: is stuff you should know. Yeah, you know before we 7 00:00:25,920 --> 00:00:28,680 Speaker 1: get go in. We are the worst self promoters. And 8 00:00:28,760 --> 00:00:32,080 Speaker 1: we consistently forget to tell people that we have a 9 00:00:32,080 --> 00:00:35,400 Speaker 1: book in a board game for sale for Christmas. That's 10 00:00:35,400 --> 00:00:38,160 Speaker 1: a great, great point. And every once in a while 11 00:00:38,200 --> 00:00:40,080 Speaker 1: they'll say things like, you know, if you guys want 12 00:00:40,080 --> 00:00:44,280 Speaker 1: to mention this, did they say? I feel like every 13 00:00:44,280 --> 00:00:48,440 Speaker 1: now and then we get emails that say, hey, did 14 00:00:48,440 --> 00:00:50,760 Speaker 1: you forget that you have these things? I don't forget. 15 00:00:50,800 --> 00:00:53,239 Speaker 1: I just assumed like everybody doesn't want to hear about it, 16 00:00:53,280 --> 00:00:57,160 Speaker 1: you know. Oh I know. But we're just not good 17 00:00:57,160 --> 00:01:01,120 Speaker 1: at this. As we stumble through at another self promotion, 18 00:01:01,560 --> 00:01:03,360 Speaker 1: they have a book in the board game and they 19 00:01:03,400 --> 00:01:06,199 Speaker 1: both make great Christmas gifts. Please stop, this is making 20 00:01:06,240 --> 00:01:10,720 Speaker 1: me so uncomfortable. Oh, buy them, everybody. Yeah, they're actually 21 00:01:10,760 --> 00:01:12,600 Speaker 1: pretty good. We're proud of both of them. I mean 22 00:01:13,040 --> 00:01:15,880 Speaker 1: we like, like we wrote a book, and we also 23 00:01:16,280 --> 00:01:18,720 Speaker 1: um with our good buddy knows Parker, I should say, 24 00:01:18,760 --> 00:01:21,040 Speaker 1: and we also helped create a board game with our 25 00:01:21,120 --> 00:01:24,600 Speaker 1: good buddies over at Trivial Pursuit. So yeah, I'm very 26 00:01:24,680 --> 00:01:26,640 Speaker 1: proud of It's a it's a legacy kind of thing, 27 00:01:26,680 --> 00:01:30,280 Speaker 1: you know. That's right. So we might have a couple 28 00:01:30,319 --> 00:01:33,160 Speaker 1: of these reminders before Christmas because they do make great 29 00:01:33,200 --> 00:01:37,600 Speaker 1: gifts for this stuff. You should know, friend in your life. Absolutely, 30 00:01:37,840 --> 00:01:40,920 Speaker 1: So that was a great idea, Chuck, And it didn't 31 00:01:40,920 --> 00:01:44,319 Speaker 1: feel so bad after all. That's right. And now onto 32 00:01:44,440 --> 00:01:50,200 Speaker 1: our probably I think eighth episode. I think that culminates. 33 00:01:50,960 --> 00:01:54,920 Speaker 1: It's culminated in this after many many episodes dealing with 34 00:01:54,920 --> 00:01:58,280 Speaker 1: this stuff. Well, that's funny that you say that, because 35 00:01:58,320 --> 00:02:02,040 Speaker 1: I was gonna caveat this with this this will we 36 00:02:02,080 --> 00:02:04,480 Speaker 1: will surely do another episode on this down the road 37 00:02:04,760 --> 00:02:08,000 Speaker 1: within the next several years, I'm sure, because you're obsessed 38 00:02:08,040 --> 00:02:11,320 Speaker 1: with it. I'm obsessed with a number one. Absolutely, it's 39 00:02:11,320 --> 00:02:13,840 Speaker 1: one of the most interesting things because this kind of 40 00:02:13,840 --> 00:02:17,600 Speaker 1: stuff we're gonna talk about, the gut, brain, microbiome access 41 00:02:18,280 --> 00:02:22,959 Speaker 1: um and it reveals, Chuck, like how little we actually 42 00:02:23,040 --> 00:02:26,360 Speaker 1: know about our bodies and how they function, but it 43 00:02:26,480 --> 00:02:31,400 Speaker 1: also provides these tantalizing clues about how cool the stuff 44 00:02:31,440 --> 00:02:34,919 Speaker 1: we have left to understand is. You know what I mean, 45 00:02:35,320 --> 00:02:38,360 Speaker 1: one day we're gonna understand exactly how our bodies function 46 00:02:38,840 --> 00:02:42,440 Speaker 1: and it's going to be mind boggling. I'm just very 47 00:02:42,480 --> 00:02:44,560 Speaker 1: excited about it. So yes, I'm obsessed with it. But 48 00:02:44,600 --> 00:02:47,200 Speaker 1: the other reason why we'll surely do it again is 49 00:02:47,240 --> 00:02:50,440 Speaker 1: because the stuff that we're going to talk about, we've 50 00:02:50,440 --> 00:02:55,480 Speaker 1: got to disclaim this episode and that it's pioneering, like 51 00:02:55,480 --> 00:02:59,919 Speaker 1: like cutting edge research, not bleeding edge, cutting edge research, 52 00:03:00,280 --> 00:03:03,560 Speaker 1: so it's going to keep evolving. But that also means Charles, 53 00:03:03,600 --> 00:03:06,600 Speaker 1: that that that you and I can just be like gee, 54 00:03:06,600 --> 00:03:08,639 Speaker 1: whiz and wow at this point because this is all 55 00:03:08,720 --> 00:03:12,520 Speaker 1: like just very early study kind of stuff. That's right, 56 00:03:12,760 --> 00:03:15,560 Speaker 1: And if you want to really get ready for this one, 57 00:03:16,200 --> 00:03:21,640 Speaker 1: you could listen to episodes on digestion, vehicle transplants, the 58 00:03:21,680 --> 00:03:27,520 Speaker 1: microbio human human microbiome, project immune system, probiotics, and even 59 00:03:27,639 --> 00:03:30,520 Speaker 1: our old buddy Fight or Flight. Yeah, and then just 60 00:03:30,560 --> 00:03:34,040 Speaker 1: listen to the one on Pyromania for kicks. Did we 61 00:03:34,080 --> 00:03:38,320 Speaker 1: do one on Pyromania? Of course, man, we did. Funny, 62 00:03:38,320 --> 00:03:41,720 Speaker 1: I was looking through the list the other day for 63 00:03:41,720 --> 00:03:43,800 Speaker 1: for a very special thing we have coming up that 64 00:03:43,800 --> 00:03:48,760 Speaker 1: we can announce yet. It's more self promotion too, which 65 00:03:48,800 --> 00:03:50,920 Speaker 1: we're very excited about. But I was looking through all 66 00:03:50,960 --> 00:03:54,320 Speaker 1: of our episodes and boy, it's getting more and more around, like, 67 00:03:54,560 --> 00:03:58,560 Speaker 1: huh what really? Yeah, imagine somebody trying to wade into 68 00:03:58,600 --> 00:04:02,520 Speaker 1: this stuff and just encountering it now, you know. Yeah. 69 00:04:02,760 --> 00:04:04,280 Speaker 1: It was at one point though, I was like, was 70 00:04:04,280 --> 00:04:07,440 Speaker 1: I abducted For a few years, I don't remember a 71 00:04:07,440 --> 00:04:09,800 Speaker 1: lot of these. Yeah, I have the same same thing 72 00:04:09,840 --> 00:04:12,880 Speaker 1: going on. But also, Chuck, now that you mentioned the list, 73 00:04:12,920 --> 00:04:15,120 Speaker 1: I want to give a huge hat tip again to 74 00:04:15,200 --> 00:04:20,280 Speaker 1: our Minister of Stats, Jill Hurley just doggedly and tirelessly 75 00:04:20,520 --> 00:04:23,560 Speaker 1: chronicles every single episode we've ever done. There's a Google 76 00:04:23,640 --> 00:04:27,839 Speaker 1: sheet out there that's open access that has every single 77 00:04:27,880 --> 00:04:30,560 Speaker 1: episode in order, including the selects or when they ran 78 00:04:30,600 --> 00:04:33,520 Speaker 1: as a select. Just it's just an amazing thing that 79 00:04:33,560 --> 00:04:36,680 Speaker 1: she's doing for free, for the love of it. I'm 80 00:04:36,720 --> 00:04:39,640 Speaker 1: guessing she still loves it. I hope Uh, well, Hurls 81 00:04:39,720 --> 00:04:44,520 Speaker 1: if nothing else is uh stubborn, she won't quit even 82 00:04:44,560 --> 00:04:49,520 Speaker 1: if so, let's talk about the gut brain microbiome access chuck, 83 00:04:49,560 --> 00:04:51,200 Speaker 1: because there's a couple of ways to look at it. 84 00:04:51,240 --> 00:04:53,119 Speaker 1: And the first way is the way that you would 85 00:04:53,120 --> 00:04:58,200 Speaker 1: expect that you do things like digest food. Um. Your 86 00:04:58,480 --> 00:05:02,559 Speaker 1: gut lining is produced mu gus um. You poop things 87 00:05:02,600 --> 00:05:05,320 Speaker 1: out after you eat them, you even swallow, and your 88 00:05:05,360 --> 00:05:08,360 Speaker 1: brain has a lot of other stuff to do than 89 00:05:08,440 --> 00:05:12,520 Speaker 1: to just micro manage that. So you have an entirely 90 00:05:12,680 --> 00:05:18,840 Speaker 1: different secondary central nervous system that's dedicated exclusively to um eating, 91 00:05:19,400 --> 00:05:24,880 Speaker 1: digesting and harvesting nutrients from your food. And that's called 92 00:05:24,880 --> 00:05:28,479 Speaker 1: the enteric nervous system. That's right, uh, And this is 93 00:05:28,520 --> 00:05:32,400 Speaker 1: definitely when we hit on in the digestion episode, but 94 00:05:32,480 --> 00:05:35,160 Speaker 1: they handle it all in the enteric nervous system. The 95 00:05:35,200 --> 00:05:37,880 Speaker 1: e n S is really um similar in a lot 96 00:05:37,920 --> 00:05:40,680 Speaker 1: of ways to our own central nervous system, and that 97 00:05:40,839 --> 00:05:46,400 Speaker 1: it's made up of uh nerves and neurons and neurotransmitters, 98 00:05:46,440 --> 00:05:48,839 Speaker 1: and it kind of does its own thing for the 99 00:05:48,880 --> 00:05:52,000 Speaker 1: most part as far as controlling that stuff without the 100 00:05:52,040 --> 00:05:56,279 Speaker 1: central nervous system lording over it. Saying you forgot this part. 101 00:05:56,920 --> 00:05:58,520 Speaker 1: You might want to move this through the intestine a 102 00:05:58,560 --> 00:06:01,120 Speaker 1: little quicker it and it does its own thing. But 103 00:06:02,760 --> 00:06:05,560 Speaker 1: this gut brain sort of connection that we're talking about 104 00:06:06,160 --> 00:06:09,200 Speaker 1: is really a connection between the e n S and 105 00:06:09,240 --> 00:06:13,200 Speaker 1: the CNS because they have figured that these two systems 106 00:06:13,560 --> 00:06:16,000 Speaker 1: talked to each other, and they talked to each other 107 00:06:16,440 --> 00:06:18,400 Speaker 1: from the gut to the brain, which is the really 108 00:06:18,560 --> 00:06:21,119 Speaker 1: surprising part. We've kind of always known that the brain 109 00:06:21,160 --> 00:06:23,640 Speaker 1: talks to the gut, but now we're learning, Hey, it 110 00:06:23,680 --> 00:06:26,920 Speaker 1: looks like the gut is actually sending messages to the brain, 111 00:06:26,960 --> 00:06:29,600 Speaker 1: and a lot of the stuff we thought was a 112 00:06:29,640 --> 00:06:34,359 Speaker 1: certain way could be actually backwards. Like ib S. Yeah, 113 00:06:34,760 --> 00:06:36,919 Speaker 1: Like we've thought for a very long time that people 114 00:06:36,960 --> 00:06:41,440 Speaker 1: with IBS UM, which is basically your your lower parts 115 00:06:41,480 --> 00:06:45,520 Speaker 1: aren't working at full um, full steam. Either you're pooping 116 00:06:45,520 --> 00:06:48,560 Speaker 1: too much and you've got really thin, watery poops, or 117 00:06:48,560 --> 00:06:51,560 Speaker 1: you're pooping too little you're constipated. Either way, you have 118 00:06:52,040 --> 00:06:55,440 Speaker 1: irritable bow. It's one of the most appropriately named syndromes 119 00:06:55,440 --> 00:06:59,359 Speaker 1: there is, right, And of course everybody's walking around knowing 120 00:06:59,400 --> 00:07:03,160 Speaker 1: that anybody who has ib s is UM suffering from 121 00:07:03,320 --> 00:07:06,080 Speaker 1: like stress or anxiety, and so it's bringing on like 122 00:07:06,160 --> 00:07:09,400 Speaker 1: digestive issues. Well, this is what this this is why 123 00:07:09,440 --> 00:07:11,440 Speaker 1: this stuff is so mind blowing? Is this the field 124 00:07:11,480 --> 00:07:16,160 Speaker 1: of research that investigates the gut brain microbiome access is saying, Actually, 125 00:07:16,400 --> 00:07:19,400 Speaker 1: it's like Chuck just said, it might go both ways. 126 00:07:19,640 --> 00:07:22,680 Speaker 1: You might have stress and anxiety not because of your 127 00:07:22,760 --> 00:07:25,679 Speaker 1: your job or you know, like you're there's some something 128 00:07:25,800 --> 00:07:28,080 Speaker 1: stressing you out. The guy down the block keeps looking 129 00:07:28,120 --> 00:07:31,200 Speaker 1: at you, weird, That's not why you're stressed out or anxious. 130 00:07:31,440 --> 00:07:35,880 Speaker 1: It's because you have IBS. That's causing your your stress 131 00:07:35,880 --> 00:07:38,640 Speaker 1: and anxiety. We may have have had it backwards all 132 00:07:38,680 --> 00:07:43,960 Speaker 1: this time. Yeah, And to be specific, like you can 133 00:07:44,040 --> 00:07:46,960 Speaker 1: get anxiety obviously because you have IBS. But what they're 134 00:07:46,960 --> 00:07:49,800 Speaker 1: saying is is that it's a chicken in the egg thing. 135 00:07:49,920 --> 00:07:52,520 Speaker 1: Is the origin of this is actually in the gut 136 00:07:53,000 --> 00:07:56,360 Speaker 1: and not like, oh, I have ib S because I'm anxious, right, 137 00:07:56,680 --> 00:07:59,120 Speaker 1: And the reason why they're saying that this is even 138 00:07:59,160 --> 00:08:02,200 Speaker 1: possible is because is that cross talk goes both ways, 139 00:08:02,280 --> 00:08:04,360 Speaker 1: Like there's a We're starting to find more and more 140 00:08:04,440 --> 00:08:08,440 Speaker 1: evidence of just how the gut could possibly speak to 141 00:08:08,640 --> 00:08:11,240 Speaker 1: the brain and send its own signals, and one of 142 00:08:11,280 --> 00:08:14,400 Speaker 1: the main ones is the vegas nerve, which made a 143 00:08:14,480 --> 00:08:17,640 Speaker 1: starring appearance in our episode on what happens in the 144 00:08:17,640 --> 00:08:20,320 Speaker 1: brain during an orgasm. The vegas nerve is all about that, 145 00:08:20,840 --> 00:08:22,880 Speaker 1: but the vegas nerve also has a lot to do 146 00:08:22,920 --> 00:08:26,640 Speaker 1: with connecting the enteric nervous system with the central nervous 147 00:08:26,640 --> 00:08:29,920 Speaker 1: system as well. Yeah, I mean we've known for a 148 00:08:29,920 --> 00:08:32,160 Speaker 1: long time. Uh, And we talked about this sum in 149 00:08:32,160 --> 00:08:35,199 Speaker 1: our Fight or Flight episode that you know, Let's say 150 00:08:35,200 --> 00:08:37,320 Speaker 1: you're out in the woods and you're camping and you 151 00:08:37,400 --> 00:08:40,160 Speaker 1: have to go to the potty, and you go and 152 00:08:40,240 --> 00:08:43,360 Speaker 1: you you squat down in the middle of nowhere. You're 153 00:08:43,440 --> 00:08:45,720 Speaker 1: enjoying your time, you're about to do your business, and 154 00:08:45,760 --> 00:08:50,760 Speaker 1: a bear pops his head up your your body. Well, 155 00:08:50,800 --> 00:08:52,320 Speaker 1: the bear is like, I know what that means, but 156 00:08:52,800 --> 00:08:54,880 Speaker 1: I'm here to interrupt that. The bears and I poop 157 00:08:54,880 --> 00:09:00,360 Speaker 1: in the woods too, that's right. Uh, that bear like 158 00:09:00,640 --> 00:09:03,680 Speaker 1: you will go on an immediate sphincter lock. And it's 159 00:09:03,720 --> 00:09:07,960 Speaker 1: not just because um, it's not just a physical reaction 160 00:09:08,120 --> 00:09:10,640 Speaker 1: you and you have like you choose to do like, oh, 161 00:09:10,640 --> 00:09:12,560 Speaker 1: I better stop what I'm doing because there's a bear. 162 00:09:12,640 --> 00:09:15,800 Speaker 1: Like your body goes into fight or flight and it 163 00:09:15,920 --> 00:09:19,360 Speaker 1: sends your brain sends a signal to your body saying, 164 00:09:19,600 --> 00:09:23,000 Speaker 1: whatever else you're doing, shut it down now, because the 165 00:09:23,040 --> 00:09:25,000 Speaker 1: most important thing going on right now is this barre 166 00:09:25,000 --> 00:09:27,400 Speaker 1: in front of you. Yeah, like the FBI guy and 167 00:09:27,480 --> 00:09:31,000 Speaker 1: die Hard, shut it down now. But that's what man, 168 00:09:31,160 --> 00:09:34,800 Speaker 1: because the brain is saying, we've got, um, we've got 169 00:09:35,280 --> 00:09:37,600 Speaker 1: much better things to do with the energy that you're 170 00:09:37,679 --> 00:09:40,160 Speaker 1: using to digest that food right now. So of course 171 00:09:40,200 --> 00:09:42,960 Speaker 1: the brain can talk to the to the enteric nervous 172 00:09:42,960 --> 00:09:46,160 Speaker 1: system when it's fight or flight time. And at this point, Chuck, 173 00:09:46,200 --> 00:09:49,120 Speaker 1: I want to give another huge hat tip to our 174 00:09:49,160 --> 00:09:52,880 Speaker 1: own Dave Rouse, who helped us with this one bang 175 00:09:52,920 --> 00:09:55,960 Speaker 1: up job. He came up with an entirely new phrase 176 00:09:56,440 --> 00:10:01,160 Speaker 1: for fight or flight battle or skitaddle. It's so good 177 00:10:01,200 --> 00:10:03,959 Speaker 1: that I wrote an email just calling that one out 178 00:10:04,000 --> 00:10:07,080 Speaker 1: to him, saying like this was a priceless term. He said, 179 00:10:07,120 --> 00:10:09,400 Speaker 1: that was all mine, so hopefully figure out a way 180 00:10:09,440 --> 00:10:12,480 Speaker 1: to copyright that one he made up for Bruce Springstein, 181 00:10:13,120 --> 00:10:16,920 Speaker 1: that's right. So um, so, yes, we know that the 182 00:10:16,960 --> 00:10:18,600 Speaker 1: brain can talk to the e N S, but the 183 00:10:18,600 --> 00:10:20,320 Speaker 1: e N S can talk to the brain via the 184 00:10:20,400 --> 00:10:23,880 Speaker 1: vegas nerve as well. And what they're figuring out is 185 00:10:23,920 --> 00:10:27,680 Speaker 1: that it communicates in a number of different ways with 186 00:10:28,200 --> 00:10:32,839 Speaker 1: the vegas nerve um specifically, uh those the and this 187 00:10:32,880 --> 00:10:37,080 Speaker 1: is why they call it the um gut brain microbiota 188 00:10:37,240 --> 00:10:41,440 Speaker 1: or microbiome access because what we're figuring out is, yes, 189 00:10:41,480 --> 00:10:46,479 Speaker 1: you have cells that lying your your intestines, your guts 190 00:10:46,520 --> 00:10:49,720 Speaker 1: that are neurons, You have neural cells, you have sensory cells, 191 00:10:49,760 --> 00:10:52,240 Speaker 1: you have a lot of the same cells that um 192 00:10:52,320 --> 00:10:55,240 Speaker 1: your brain uses to make sense of the world. Where 193 00:10:55,280 --> 00:10:58,840 Speaker 1: your gut has those same cells too. But we're figuring 194 00:10:58,840 --> 00:11:02,520 Speaker 1: out that the bacteria that lives in your gut is 195 00:11:02,600 --> 00:11:07,640 Speaker 1: actually communicating to your brain and saying, hey, change this behavior, 196 00:11:07,800 --> 00:11:11,640 Speaker 1: Hey try this instead. Hey have you considered a red sweater? 197 00:11:11,920 --> 00:11:16,040 Speaker 1: Greens just not your color, Like, the bacteria that live 198 00:11:16,080 --> 00:11:18,640 Speaker 1: in our gut are telling our brains what to do. 199 00:11:18,720 --> 00:11:22,679 Speaker 1: In some ways, it's pretty remarkable. This is why we 200 00:11:22,760 --> 00:11:27,640 Speaker 1: keep talking about this chuck. The bacteria. In addition to 201 00:11:27,760 --> 00:11:31,319 Speaker 1: doing all the other great things they do, they produce metabolites, 202 00:11:32,120 --> 00:11:37,079 Speaker 1: and these metabolites actually do function as neurotransmitters. And one 203 00:11:37,080 --> 00:11:39,960 Speaker 1: of the big examples that Dave dug up and this 204 00:11:40,040 --> 00:11:41,840 Speaker 1: is it's a big part of kind of one of 205 00:11:41,880 --> 00:11:44,640 Speaker 1: the cruxes of this communication with the gut in the 206 00:11:44,679 --> 00:11:48,000 Speaker 1: brain or these short chain fatty acids s f c 207 00:11:48,200 --> 00:11:53,760 Speaker 1: A s. They are byproducts, are natural byproducts of fermentation 208 00:11:54,920 --> 00:11:58,720 Speaker 1: when you're digesting this dietary fiber, if you're hopefully eating 209 00:11:58,800 --> 00:12:00,719 Speaker 1: enough dietary fiber, something I've had to do a lot 210 00:12:00,720 --> 00:12:03,840 Speaker 1: more lately. It's so good for you, it's crazy. It 211 00:12:03,880 --> 00:12:07,320 Speaker 1: seems like the key to health. It is. And I 212 00:12:07,320 --> 00:12:10,600 Speaker 1: don't want to get to uh gross here, but I've 213 00:12:10,640 --> 00:12:13,439 Speaker 1: been on a lot of high fiber and I have 214 00:12:13,520 --> 00:12:17,400 Speaker 1: been more gassy than I've ever been in my life. 215 00:12:18,600 --> 00:12:22,199 Speaker 1: And it's not even stinky gassy. It's just it's almost 216 00:12:22,240 --> 00:12:28,280 Speaker 1: just like air. Very lucky. Yeah, because those are saying my, my, 217 00:12:28,280 --> 00:12:31,480 Speaker 1: my toots don't stink anymore at all ever, But these 218 00:12:31,559 --> 00:12:34,840 Speaker 1: like fiber toots don't really stink. That is really bizarre, 219 00:12:34,920 --> 00:12:40,480 Speaker 1: because cruciferous vegetable toots can really clear room. I guess 220 00:12:40,480 --> 00:12:43,080 Speaker 1: there is a way to put it. That's your blessed, chuck, 221 00:12:43,120 --> 00:12:47,520 Speaker 1: your hashtag blessed. Oh well, my family's blessed, I guess. 222 00:12:47,720 --> 00:12:51,800 Speaker 1: But because I don't really care, but you're like, I 223 00:12:51,880 --> 00:12:55,240 Speaker 1: kind of miss it. But where were we short chain 224 00:12:55,280 --> 00:12:59,240 Speaker 1: fatty acids. Um, they are, like I said, natural byproducts, 225 00:12:59,240 --> 00:13:02,480 Speaker 1: and they play a really big role in the digestive track. 226 00:13:02,600 --> 00:13:05,280 Speaker 1: And they're sending there one of the things sending these 227 00:13:05,679 --> 00:13:09,480 Speaker 1: signals to your e n s and they're saying, hey, 228 00:13:09,559 --> 00:13:12,880 Speaker 1: maybe you should make more mucus. Maybe I can get 229 00:13:12,920 --> 00:13:16,120 Speaker 1: the gut a little less inflamed um, maybe I can 230 00:13:16,160 --> 00:13:20,800 Speaker 1: stop a little leakage from happening. And so so the 231 00:13:20,840 --> 00:13:25,959 Speaker 1: short chain fatty acids themselves, they're they're they're involved in neurotransmitters, 232 00:13:26,000 --> 00:13:29,040 Speaker 1: but apparently they can talk to the brain themselves to right, 233 00:13:29,200 --> 00:13:32,719 Speaker 1: like they don't have to convert into anything else, I think, 234 00:13:32,760 --> 00:13:35,280 Speaker 1: so like just through through the vegas nerve. Right, yes, 235 00:13:35,440 --> 00:13:38,040 Speaker 1: and so so here's where we're at. Yes, they go 236 00:13:38,120 --> 00:13:40,560 Speaker 1: through the vegas nerve. That's the key here, um. And 237 00:13:40,600 --> 00:13:43,840 Speaker 1: we've recently found a new kind of cell that line 238 00:13:44,000 --> 00:13:49,440 Speaker 1: the the gut that are actually connected. They connect the 239 00:13:49,520 --> 00:13:53,480 Speaker 1: gut to the vegas nerve. They're called neuropods cells. And 240 00:13:53,520 --> 00:13:56,400 Speaker 1: that's how they think that the gut is actually communicating 241 00:13:56,520 --> 00:13:58,360 Speaker 1: with the brain through the vegas nerve. They think they 242 00:13:58,440 --> 00:14:00,440 Speaker 1: found kind of like the smoking gun to the missing 243 00:14:00,480 --> 00:14:04,000 Speaker 1: link or whatever. But um, that's how these short chain 244 00:14:04,040 --> 00:14:06,240 Speaker 1: fatty acids would travel up the nerve, they would send 245 00:14:06,280 --> 00:14:09,880 Speaker 1: their signal up the nerve, or they would travel through 246 00:14:09,880 --> 00:14:12,640 Speaker 1: the circulatory system, which is another way that they figured 247 00:14:12,679 --> 00:14:16,720 Speaker 1: out the gut can actually impact the brain. Is so 248 00:14:16,760 --> 00:14:19,200 Speaker 1: you get the vagus, nerve um, and then you have 249 00:14:19,240 --> 00:14:22,840 Speaker 1: the circulatory system. And if all of those metabolites that 250 00:14:22,880 --> 00:14:25,880 Speaker 1: are being produced by your bacteria, they're fermenting in different 251 00:14:25,880 --> 00:14:30,680 Speaker 1: bacteria ferment create different metabolites as they ferment your food 252 00:14:30,720 --> 00:14:33,840 Speaker 1: and your dietary fiber, and those metabolites, like you said, 253 00:14:33,880 --> 00:14:37,120 Speaker 1: sometimes they're short chain fatty acids sometimes which can be 254 00:14:37,160 --> 00:14:41,920 Speaker 1: like a precursor to neurotransmitters or possibly a neuro transmitter itself. 255 00:14:42,480 --> 00:14:50,480 Speaker 1: They actually build actual neurotransmitters to like seratonin, UM, dopamine, GABBA, 256 00:14:50,800 --> 00:14:55,720 Speaker 1: nor adrenaline. All these things are actually constructed by the 257 00:14:55,800 --> 00:14:58,600 Speaker 1: bacteria in your gut as well. And we know for 258 00:14:58,760 --> 00:15:00,840 Speaker 1: a fact that those things can make it through the 259 00:15:00,880 --> 00:15:04,600 Speaker 1: circulatory system to the brain and they definitely have an 260 00:15:04,640 --> 00:15:08,000 Speaker 1: impact on the brain and what the brain does. All right, 261 00:15:08,000 --> 00:15:10,440 Speaker 1: maybe we should take a break, all right, take a 262 00:15:10,440 --> 00:15:13,160 Speaker 1: pause for the cause I'm just gonna keep talking through 263 00:15:13,200 --> 00:15:16,600 Speaker 1: the ad break. I'm too excited, all right, We'll be 264 00:15:16,640 --> 00:15:46,240 Speaker 1: back right after this. I skate, all right. So when 265 00:15:46,280 --> 00:15:49,840 Speaker 1: we left, we were talking about a lot of stuff 266 00:15:49,880 --> 00:15:53,520 Speaker 1: that sounds pretty amazing and that we're just figuring out, 267 00:15:53,800 --> 00:15:57,880 Speaker 1: one of which is that, uh, the short chain fatty 268 00:15:57,920 --> 00:16:01,360 Speaker 1: acids are actually able to stimulate that vegas nerve that 269 00:16:01,400 --> 00:16:05,920 Speaker 1: we were talking about that stimulates nerrow the production of neurotransmitters. 270 00:16:05,960 --> 00:16:08,880 Speaker 1: But here's sort of the the headline is some of 271 00:16:08,920 --> 00:16:12,600 Speaker 1: these neurotransmitters can actually play a role in mood disorders. 272 00:16:13,520 --> 00:16:17,960 Speaker 1: So we're not just talking about um a two way 273 00:16:18,000 --> 00:16:20,080 Speaker 1: street with things like fight or flight. We're talking about 274 00:16:20,640 --> 00:16:25,680 Speaker 1: potentially autism, Parkinson's depression, anxiety like we were talking about 275 00:16:25,720 --> 00:16:28,840 Speaker 1: with IBS. And they know this because they took in 276 00:16:28,880 --> 00:16:32,680 Speaker 1: these poor little mice that they're always, you know, doing 277 00:16:32,720 --> 00:16:36,120 Speaker 1: the hard work on mice, but they've taken mice. They've 278 00:16:36,120 --> 00:16:39,520 Speaker 1: severed the vegas nerve in mice to see what happened. 279 00:16:40,080 --> 00:16:44,120 Speaker 1: And what they observed was that this gut bacteria had 280 00:16:44,160 --> 00:16:46,480 Speaker 1: a real effect on brain chemistry because when they shut 281 00:16:46,480 --> 00:16:50,880 Speaker 1: it down, they found big time reduction in stress hormone levels. 282 00:16:50,920 --> 00:16:54,240 Speaker 1: Like they completely went away in these mice, right would 283 00:16:54,280 --> 00:16:57,240 Speaker 1: you would think they're stress hormones would go up having 284 00:16:57,280 --> 00:16:59,960 Speaker 1: their vegus nerves ever, that would be a really stressful thing. 285 00:17:00,080 --> 00:17:02,920 Speaker 1: But now, um so that but that that's really like 286 00:17:02,960 --> 00:17:06,080 Speaker 1: a good illustration of the point that we're at in research. 287 00:17:06,119 --> 00:17:09,040 Speaker 1: We there's there's not been a thing where it's like, oh, 288 00:17:09,240 --> 00:17:11,280 Speaker 1: this is exactly how this happens. This is how your 289 00:17:11,320 --> 00:17:16,280 Speaker 1: gut microbiota affects you know, your your your brain and 290 00:17:16,440 --> 00:17:19,159 Speaker 1: your brain chemistry. We're not there yet. We just know 291 00:17:19,280 --> 00:17:22,680 Speaker 1: that there is a definite correlation, not just in my studies, Chuck, 292 00:17:22,760 --> 00:17:26,480 Speaker 1: but also in um human studies, which we'll talk about later. 293 00:17:26,640 --> 00:17:29,080 Speaker 1: Like there's plenty of human diseases that we've long known 294 00:17:29,440 --> 00:17:33,120 Speaker 1: if you have this disease, you also have like irritable 295 00:17:33,119 --> 00:17:36,479 Speaker 1: but irritable bowel syndrome or constipation is a hallmark of 296 00:17:36,520 --> 00:17:41,440 Speaker 1: this neurological disorder that um that you wouldn't expect. We've 297 00:17:41,480 --> 00:17:44,840 Speaker 1: known that they're connected, and that's it's all kind of correlative. 298 00:17:45,160 --> 00:17:47,280 Speaker 1: Now we're trying to figure out the causes of it. 299 00:17:48,160 --> 00:17:51,399 Speaker 1: That's right, and it's not just like this communication isn't 300 00:17:51,480 --> 00:17:54,359 Speaker 1: only happening through the vegus nerve. Uh. You kind of 301 00:17:54,359 --> 00:17:57,080 Speaker 1: briefly mentioned before the break. But there are all kinds 302 00:17:57,080 --> 00:17:59,360 Speaker 1: of ways that they're communicating that we're founding out. One 303 00:17:59,359 --> 00:18:03,199 Speaker 1: of them is through the circulatory system. We used to 304 00:18:03,240 --> 00:18:06,480 Speaker 1: think that the brain was just sort of shut down 305 00:18:06,560 --> 00:18:10,200 Speaker 1: from behind the blood brain barrier. But now they're they're 306 00:18:10,200 --> 00:18:13,800 Speaker 1: showing that, like hormones are getting through there, other things 307 00:18:13,800 --> 00:18:16,680 Speaker 1: are passing through. We've known about grellin. We've talked about 308 00:18:16,720 --> 00:18:19,879 Speaker 1: grellin for a while, the hunger hormone that basically the 309 00:18:19,920 --> 00:18:22,399 Speaker 1: stomach produces. It sends a message to the brain that 310 00:18:22,400 --> 00:18:25,040 Speaker 1: says I'm hungry. So we've known that can pass through. 311 00:18:25,560 --> 00:18:29,159 Speaker 1: But now they're learning things Like you mentioned serotonin to me. 312 00:18:29,320 --> 00:18:31,960 Speaker 1: This is one of the facts of the show of 313 00:18:31,960 --> 00:18:37,960 Speaker 1: our Serantonin is actually produced by gut bacteria. Yeah, and um, 314 00:18:38,000 --> 00:18:40,480 Speaker 1: I mean the brain also can produce serotonin, It can 315 00:18:40,520 --> 00:18:45,640 Speaker 1: produce its own, But it appears that right that the serotonin, 316 00:18:46,000 --> 00:18:48,639 Speaker 1: a lot of the serotonin that the brain uses comes 317 00:18:48,640 --> 00:18:54,760 Speaker 1: from the gut, comes from bacteria fermenting food and producing 318 00:18:54,800 --> 00:18:58,159 Speaker 1: as a biproduct of metabolism. It just so happens to 319 00:18:58,200 --> 00:19:01,360 Speaker 1: produce this neurotransmitter. And I don't think I don't think 320 00:19:01,359 --> 00:19:04,200 Speaker 1: anybody who's looking into this is saying it just so happens, 321 00:19:04,480 --> 00:19:08,080 Speaker 1: like we appear to have co evolved to take advantage 322 00:19:08,080 --> 00:19:13,160 Speaker 1: of this, Like these bacteria started colonizing our guts producing 323 00:19:13,200 --> 00:19:16,480 Speaker 1: serotonin so much that our bodies found a way to 324 00:19:16,600 --> 00:19:19,920 Speaker 1: really use serotonin in all sorts of different ways, including 325 00:19:20,200 --> 00:19:22,919 Speaker 1: our brain to regulate mood and stuff like that. And 326 00:19:23,000 --> 00:19:25,639 Speaker 1: that's like one of the one of the huge underlying 327 00:19:25,680 --> 00:19:29,439 Speaker 1: messages of this is that our microbiome, the bacteria that 328 00:19:29,480 --> 00:19:32,479 Speaker 1: live inside of us, they have way more genes than 329 00:19:32,520 --> 00:19:35,800 Speaker 1: we have. We have something like to genes in the 330 00:19:35,880 --> 00:19:39,880 Speaker 1: human genome, but our microbiome typically has something like two 331 00:19:39,920 --> 00:19:43,840 Speaker 1: million combined genes. And with those genes, with all those 332 00:19:43,880 --> 00:19:46,480 Speaker 1: extra genes that we don't have, all that bacteria can 333 00:19:46,520 --> 00:19:49,960 Speaker 1: produce stuff that we can't even produce, like vitamins and 334 00:19:50,000 --> 00:19:52,800 Speaker 1: neurotransmitters that we wouldn't necessarily be able to produce on 335 00:19:52,840 --> 00:19:56,760 Speaker 1: our own, and yet we rely on to function correctly. 336 00:19:57,440 --> 00:20:02,640 Speaker 1: That's that's like, that's the most amazing example of symbiosis 337 00:20:02,680 --> 00:20:05,120 Speaker 1: I've ever heard in my life. But the idea that 338 00:20:05,200 --> 00:20:09,960 Speaker 1: bacteria fermenting food in your gut chuck affects your mood 339 00:20:10,119 --> 00:20:13,000 Speaker 1: or your outlook or whether you have a um a 340 00:20:13,080 --> 00:20:19,639 Speaker 1: cognitive disorder. Like that's really substantial. It's super it's super substantial. 341 00:20:19,800 --> 00:20:22,320 Speaker 1: I know, I feel like I could have come up 342 00:20:22,359 --> 00:20:26,000 Speaker 1: with a better descriptor than really substantial, But I'm just 343 00:20:26,200 --> 00:20:31,840 Speaker 1: to agog. Should we talk about the study of college students? Yea, 344 00:20:32,480 --> 00:20:34,920 Speaker 1: as far as you know, trying to provide a link 345 00:20:35,000 --> 00:20:38,199 Speaker 1: between stretch, like a two way street between stress and 346 00:20:38,240 --> 00:20:41,320 Speaker 1: our gut. Uh. They said, well, there's no better place 347 00:20:41,359 --> 00:20:45,679 Speaker 1: to go than to college students who are prepping for exams. 348 00:20:46,119 --> 00:20:48,240 Speaker 1: And they said, if we're going to find out what's 349 00:20:48,240 --> 00:20:50,040 Speaker 1: going on down there, we need to look at their stools. 350 00:20:50,800 --> 00:20:53,919 Speaker 1: And they tested the stools during exam week and found 351 00:20:53,960 --> 00:20:59,040 Speaker 1: that their feces had a lot less lactobacilly, which is 352 00:20:59,040 --> 00:21:01,399 Speaker 1: one of the good back tier. Is then during the 353 00:21:01,400 --> 00:21:04,480 Speaker 1: first week week of class when they're just getting to 354 00:21:04,520 --> 00:21:08,359 Speaker 1: know each other and partying and stuff like that. The 355 00:21:08,440 --> 00:21:11,600 Speaker 1: same when they studied monkeys, little infant monkeys, And it's 356 00:21:11,640 --> 00:21:13,879 Speaker 1: one of those tests that's a little bit sad. No 357 00:21:13,880 --> 00:21:17,240 Speaker 1: one's dying here, but they're stressing out mama monkeys on purpose. 358 00:21:17,960 --> 00:21:20,120 Speaker 1: So they've got these mama monkeys and they'll play these 359 00:21:20,119 --> 00:21:23,800 Speaker 1: loud noises while they're pregnant to kind of like shock them. 360 00:21:24,359 --> 00:21:28,399 Speaker 1: And with the mothers who had to say, what, I 361 00:21:28,480 --> 00:21:30,720 Speaker 1: gotta stop you. I'm sorry, you just made a shock 362 00:21:30,840 --> 00:21:36,800 Speaker 1: the Monkey joke without even intending. Yes, I could not 363 00:21:36,960 --> 00:21:44,240 Speaker 1: let that walk by. Congratulations on the monkey Monkey great song. 364 00:21:44,800 --> 00:21:49,200 Speaker 1: Did you know I gotta shut the monkey? Do? Dude? 365 00:21:49,320 --> 00:21:52,359 Speaker 1: Do dude? Um? I wonder if they just walk around 366 00:21:52,400 --> 00:21:56,720 Speaker 1: singing that constantly? He was. Probably there's no way they don't. 367 00:21:56,760 --> 00:21:59,000 Speaker 1: And then they get home at night and they're like, oh, 368 00:21:59,119 --> 00:22:00,879 Speaker 1: and they feel a little get about it because they 369 00:22:00,880 --> 00:22:03,280 Speaker 1: remember why they're singing shock the Monkey, because they're actually 370 00:22:03,320 --> 00:22:07,040 Speaker 1: shocking monkeys for a living. Or and we mean shocking 371 00:22:07,040 --> 00:22:10,240 Speaker 1: with loud noises, not shocking with electricity. Right, Well, yeah, 372 00:22:10,320 --> 00:22:13,639 Speaker 1: that's what I guess. Peter Gabriel men too, But no, 373 00:22:13,840 --> 00:22:15,440 Speaker 1: I think about I don't know, maybe he was talking 374 00:22:15,440 --> 00:22:18,600 Speaker 1: about with electricity or I wonder if there's just one 375 00:22:18,720 --> 00:22:21,800 Speaker 1: person like the person who runs the lab on their 376 00:22:21,840 --> 00:22:24,720 Speaker 1: way out says, you know, because they probably do it 377 00:22:24,720 --> 00:22:26,080 Speaker 1: in their sleep there so you remember you got to 378 00:22:26,080 --> 00:22:29,280 Speaker 1: shock the monkey tonight, and they everyone else just rolls 379 00:22:29,280 --> 00:22:31,640 Speaker 1: their eyes and they have to They have to put 380 00:22:31,720 --> 00:22:35,320 Speaker 1: up with Marty where the lab yeah, and where's the 381 00:22:35,440 --> 00:22:39,240 Speaker 1: piano keyboard? Tie? Every day. But they're different ones too, 382 00:22:39,240 --> 00:22:41,160 Speaker 1: because some of them have red backgrounds. You can tell 383 00:22:41,200 --> 00:22:44,800 Speaker 1: they're a little different alright. So, uh so they make 384 00:22:44,840 --> 00:22:47,720 Speaker 1: these loud noises and then the monkey, the mama monkeys 385 00:22:47,720 --> 00:22:53,440 Speaker 1: who were shocked, uh by these sounds, they had gut 386 00:22:53,520 --> 00:22:57,639 Speaker 1: microbiomes with a lot lower levels of this good bacteria 387 00:22:57,680 --> 00:23:04,919 Speaker 1: of lactobacilly and boy bifi doughe bacteria, bacteria that's like 388 00:23:04,960 --> 00:23:08,200 Speaker 1: stuff in yogurt, I think both of those, which we'll 389 00:23:08,200 --> 00:23:13,760 Speaker 1: get to all right there. But they had a despotic 390 00:23:14,359 --> 00:23:17,400 Speaker 1: disbiotic microbiome. Is the upshot of it, right, You get 391 00:23:17,440 --> 00:23:21,040 Speaker 1: unbalanced basically because of these stress noises that they hear, right, So, 392 00:23:21,280 --> 00:23:23,440 Speaker 1: but it goes the other way too, that they're figuring 393 00:23:23,440 --> 00:23:27,080 Speaker 1: out that if your gut microbiome gets out of balance, 394 00:23:27,280 --> 00:23:30,200 Speaker 1: then that can make you stressed out right, that can 395 00:23:30,359 --> 00:23:33,320 Speaker 1: that can actually lead to mood disorders that they're they're 396 00:23:33,320 --> 00:23:36,159 Speaker 1: connecting like a really poor diet. It's very low and 397 00:23:36,240 --> 00:23:39,120 Speaker 1: like dietary fiber, because again, that's what your microbiome likes 398 00:23:39,119 --> 00:23:42,600 Speaker 1: to crunch on and produces really important things like serotonin 399 00:23:42,680 --> 00:23:45,560 Speaker 1: and dope. I mean from that, if you don't eat 400 00:23:45,640 --> 00:23:49,080 Speaker 1: very well, it's possible your mood might not be as great, 401 00:23:49,280 --> 00:23:52,640 Speaker 1: or your outlook on life, or your mental health might 402 00:23:52,680 --> 00:23:55,159 Speaker 1: not be as great as it could be if you 403 00:23:55,200 --> 00:23:59,640 Speaker 1: actually did have a much healthier diet. That is very 404 00:23:59,680 --> 00:24:02,760 Speaker 1: sub stanchel it is, and I think that kind of 405 00:24:02,760 --> 00:24:05,680 Speaker 1: stuff kind of feeds on each other. It becomes this 406 00:24:05,880 --> 00:24:09,520 Speaker 1: circular loop. Yeah, well that was something that was that 407 00:24:09,880 --> 00:24:11,879 Speaker 1: Dave pointed out to that they're starting to realize that 408 00:24:12,240 --> 00:24:15,200 Speaker 1: your CNS, your central nervous system, and your entire nervous 409 00:24:15,200 --> 00:24:19,160 Speaker 1: system are probably in communication constantly. They're just sharing information 410 00:24:19,200 --> 00:24:21,520 Speaker 1: back and forth because there's no it doesn't make any 411 00:24:21,520 --> 00:24:24,480 Speaker 1: evolutionary sense for your bacteria to just be running the 412 00:24:24,520 --> 00:24:26,680 Speaker 1: show and telling your brain what to do. That's one 413 00:24:26,680 --> 00:24:29,320 Speaker 1: of the grimmest things I can possibly imagine, is that 414 00:24:29,320 --> 00:24:33,159 Speaker 1: we're actually just puppets for bacteria and our guts. But 415 00:24:33,200 --> 00:24:34,920 Speaker 1: at the same time, it doesn't make sense for your 416 00:24:34,920 --> 00:24:36,639 Speaker 1: brain to be controlling your e n S. Your e 417 00:24:36,800 --> 00:24:40,560 Speaker 1: n S is a semi autonomous nervous system, so they're 418 00:24:40,560 --> 00:24:43,439 Speaker 1: not bossing each other around. They're just sharing information and 419 00:24:43,520 --> 00:24:46,919 Speaker 1: then making adjustments accordingly. But they can also affect one 420 00:24:46,960 --> 00:24:49,920 Speaker 1: another and impact one another negatively when things are out 421 00:24:49,920 --> 00:24:52,560 Speaker 1: of whack, whether you're stressed out, it can affect your gut, 422 00:24:52,800 --> 00:24:54,960 Speaker 1: or if your gut's not doing well, it can stress 423 00:24:55,000 --> 00:24:58,880 Speaker 1: you out. That's what we're trying. And that is so 424 00:24:58,920 --> 00:25:05,040 Speaker 1: substantial is that the second time he said that third third, 425 00:25:05,280 --> 00:25:06,880 Speaker 1: I don't think you picked up the second one. That's 426 00:25:06,880 --> 00:25:09,359 Speaker 1: all right, and this is like the reason this is 427 00:25:09,400 --> 00:25:12,200 Speaker 1: big stuff. And if you're wondering, like, yeah, but where 428 00:25:12,240 --> 00:25:15,160 Speaker 1: is this all leading, We're about to tell you because 429 00:25:15,760 --> 00:25:18,879 Speaker 1: if you have uh, I mean it's not just ib S, 430 00:25:18,920 --> 00:25:21,919 Speaker 1: if you have Parkinson's, or if you or a family 431 00:25:21,960 --> 00:25:27,080 Speaker 1: member is on the autism spectrum disorder. They're not saying 432 00:25:27,119 --> 00:25:29,760 Speaker 1: that they can cure this stuff, but they are finding 433 00:25:29,760 --> 00:25:34,840 Speaker 1: out very promising tests and studies that things like Parkinson's 434 00:25:34,840 --> 00:25:39,679 Speaker 1: and autism can be um can be mitigated somewhat with 435 00:25:39,760 --> 00:25:43,000 Speaker 1: the use of certain probiotics and maybe in the future 436 00:25:43,040 --> 00:25:46,960 Speaker 1: fecal transplants. Yeah, I don't think anybody credible is saying like, oh, 437 00:25:47,160 --> 00:25:50,720 Speaker 1: we can cure autism spectrum disorder with um, you know, 438 00:25:50,800 --> 00:25:53,600 Speaker 1: probiotics or something like that. But there's a lot of 439 00:25:53,640 --> 00:25:56,960 Speaker 1: mounting evidence that you can alleviate a lot of the symptoms, 440 00:25:57,000 --> 00:26:02,080 Speaker 1: including things like UM uh like behavior that like social 441 00:26:02,119 --> 00:26:06,680 Speaker 1: avoidance UM or not being interested in social novelty, UM, 442 00:26:06,720 --> 00:26:10,080 Speaker 1: A lot of the classic symptoms that as associated with 443 00:26:10,119 --> 00:26:13,840 Speaker 1: autism spectrum to sword that in my studies at least, 444 00:26:15,840 --> 00:26:18,920 Speaker 1: do they clear up a little bit, they adjust, They 445 00:26:18,960 --> 00:26:21,600 Speaker 1: actually kind of go away in some cases when you 446 00:26:21,680 --> 00:26:25,920 Speaker 1: adjust the gut microbiota of these mice who have the 447 00:26:26,480 --> 00:26:30,840 Speaker 1: mice analogy of autism. Yeah, and you know g I 448 00:26:30,920 --> 00:26:36,320 Speaker 1: problems are UM not always, but pretty much synonymous with 449 00:26:36,680 --> 00:26:41,840 Speaker 1: autism spectrum disorder. Uh. If you have Parkinson's, you probably 450 00:26:41,880 --> 00:26:45,800 Speaker 1: also have constipation. This has been true from the very 451 00:26:45,840 --> 00:26:50,480 Speaker 1: first patients that were diagnosed by by Dr Parkinson himself. 452 00:26:50,520 --> 00:26:53,720 Speaker 1: He realized that you also have constipation back then. This 453 00:26:53,760 --> 00:26:56,119 Speaker 1: is sort of in the age where I can't remember 454 00:26:56,119 --> 00:26:57,760 Speaker 1: one of the recent episodes where he used to sort 455 00:26:57,760 --> 00:27:03,919 Speaker 1: of have colonics and enemas for almost everything. Well, that 456 00:27:04,000 --> 00:27:07,520 Speaker 1: was probably the Kellogg's episode. Now we referenced the it 457 00:27:07,560 --> 00:27:09,520 Speaker 1: was like a couple of weeks ago. Okay. I don't 458 00:27:09,520 --> 00:27:12,240 Speaker 1: know why we talked about colonics and animals a lot 459 00:27:12,400 --> 00:27:15,000 Speaker 1: in this show. I think it was maybe we're talking 460 00:27:15,000 --> 00:27:18,000 Speaker 1: about the bleeders the barber's. Uh, yeah, that was it, 461 00:27:18,040 --> 00:27:20,119 Speaker 1: because they used to give people animals for everything. But 462 00:27:20,720 --> 00:27:22,639 Speaker 1: they may have been onto something a little bit. Is 463 00:27:22,800 --> 00:27:24,800 Speaker 1: like kind of quacky as it sounded back in the 464 00:27:24,880 --> 00:27:29,240 Speaker 1: day where if you had Parkinson's and constipation, they would 465 00:27:29,720 --> 00:27:32,080 Speaker 1: give you a colonic or something or an enema and 466 00:27:32,160 --> 00:27:35,080 Speaker 1: it would kind of help your Parkinson's out. And people 467 00:27:35,119 --> 00:27:37,040 Speaker 1: dismiss that a long time ago, but they may have 468 00:27:37,080 --> 00:27:39,439 Speaker 1: actually been onto something a little bit there. Yeah. The 469 00:27:39,520 --> 00:27:42,640 Speaker 1: idea is that this is the current understanding of why 470 00:27:42,920 --> 00:27:47,520 Speaker 1: Parkinson's and um and and gut issues may be related, 471 00:27:47,640 --> 00:27:50,520 Speaker 1: is that they actually think it might start with gut issues. 472 00:27:50,600 --> 00:27:54,160 Speaker 1: That you have a certain type of E. Coli that's 473 00:27:54,200 --> 00:27:58,000 Speaker 1: producing a protein called curly su r l i, and 474 00:27:58,080 --> 00:28:02,720 Speaker 1: that curly has an effect in causing other proteins to misfold, 475 00:28:02,840 --> 00:28:06,440 Speaker 1: which makes it a pre on. Remember those. Yeah, So 476 00:28:06,760 --> 00:28:11,320 Speaker 1: this pre on curly causes misfolding of proteins in your gut. Uh, 477 00:28:11,359 --> 00:28:14,359 Speaker 1: they end up clumping, which ends up constipating you. And 478 00:28:14,440 --> 00:28:18,040 Speaker 1: this process starts a good twenty years before you show 479 00:28:18,080 --> 00:28:21,520 Speaker 1: the classic symptoms of Parkinson's. This is amazing, right, But 480 00:28:21,640 --> 00:28:24,400 Speaker 1: the point is is that by this time, after twenty years, 481 00:28:24,440 --> 00:28:27,040 Speaker 1: your curly production has gotten so good that it starts 482 00:28:27,040 --> 00:28:29,840 Speaker 1: to travel up to the brain where it starts misfolding 483 00:28:29,840 --> 00:28:32,800 Speaker 1: proteins up there, and then you start to have the 484 00:28:32,880 --> 00:28:37,120 Speaker 1: classic symptoms of Parkinson's like tremors and shaking and eventually 485 00:28:37,160 --> 00:28:41,280 Speaker 1: possibly even hallucinations and things like that. Um that that 486 00:28:41,440 --> 00:28:43,720 Speaker 1: is all that, but that it all starts in your 487 00:28:43,720 --> 00:28:47,280 Speaker 1: gut with these um the E coli that that is 488 00:28:47,320 --> 00:28:52,160 Speaker 1: colonized your gut miss creating this curly protein pre on. Yeah, 489 00:28:52,200 --> 00:28:55,920 Speaker 1: and this is one of those where like research is 490 00:28:55,960 --> 00:28:59,520 Speaker 1: gonna help hopefully yield some uh if not cure some 491 00:28:59,600 --> 00:29:02,120 Speaker 1: things that and help mitigate some of the effects of Parkinson's. 492 00:29:02,160 --> 00:29:04,920 Speaker 1: But what it really could do is service and an 493 00:29:04,920 --> 00:29:07,360 Speaker 1: early warning system. That's not to say that if you 494 00:29:07,400 --> 00:29:11,600 Speaker 1: have constipation, you're gonna get Parkinson's in twenty years, but 495 00:29:11,760 --> 00:29:15,880 Speaker 1: if you have chronic constipation, and it could be one 496 00:29:15,920 --> 00:29:18,800 Speaker 1: of those things that they then look out and say, hey, 497 00:29:18,840 --> 00:29:21,800 Speaker 1: this is something we might need to watch out for, right. 498 00:29:22,520 --> 00:29:25,840 Speaker 1: And that's actually I've seen somebody proposing a paper from 499 00:29:25,880 --> 00:29:29,600 Speaker 1: I think this year, UM, that you that that you 500 00:29:29,760 --> 00:29:33,680 Speaker 1: use the bio markers of what's called leaky gut UM 501 00:29:33,720 --> 00:29:38,800 Speaker 1: as a early diagnosis of autism, because autism is usually 502 00:29:38,800 --> 00:29:43,240 Speaker 1: diagnosed after a few years of age UM I think 503 00:29:43,280 --> 00:29:45,560 Speaker 1: maybe three or five or something like that, that they 504 00:29:45,560 --> 00:29:49,320 Speaker 1: don't typically diagnose it before then, but that you would 505 00:29:49,400 --> 00:29:52,240 Speaker 1: have leaky gut like long before this, and you could 506 00:29:52,560 --> 00:29:55,760 Speaker 1: you know, find it and possibly treat it because so 507 00:29:55,880 --> 00:29:59,480 Speaker 1: leaky gut is this idea where your your your gut 508 00:29:59,520 --> 00:30:02,320 Speaker 1: lining is meant to be semi permeable, where only the 509 00:30:02,360 --> 00:30:05,240 Speaker 1: stuff your gut wants to make it through, like nutrients 510 00:30:05,280 --> 00:30:09,120 Speaker 1: and neurotransmitters and stuff like that UM, are able to 511 00:30:09,160 --> 00:30:12,560 Speaker 1: pass through. Leaky gut is where you have basically holes 512 00:30:12,600 --> 00:30:16,560 Speaker 1: and cracks and that that that lining and so unwanted 513 00:30:16,600 --> 00:30:21,680 Speaker 1: stuff like toxins and bogs and um partially digestive food 514 00:30:21,880 --> 00:30:25,200 Speaker 1: can make it through your gut and causes inflammation and 515 00:30:25,240 --> 00:30:28,240 Speaker 1: then there's this whole cascading problem. And that that is 516 00:30:28,320 --> 00:30:32,120 Speaker 1: why UM leaky gut is associated with things like autism 517 00:30:32,200 --> 00:30:34,640 Speaker 1: and I think even rhuma, toy arthritis, and a whole 518 00:30:34,680 --> 00:30:37,400 Speaker 1: host of other other diseases. So they're saying, if we 519 00:30:37,440 --> 00:30:39,440 Speaker 1: look for leaky gut and we find it, there's a 520 00:30:39,440 --> 00:30:43,320 Speaker 1: good chance. I think, like people on the autism spectrum 521 00:30:43,640 --> 00:30:46,280 Speaker 1: have leaky gut as well, UM, that that would be 522 00:30:46,280 --> 00:30:51,040 Speaker 1: a pretty good indication of autism diagnosis later in life. Yeah. 523 00:30:51,120 --> 00:30:53,520 Speaker 1: I talked to uh one of my really good friends 524 00:30:53,560 --> 00:30:56,080 Speaker 1: has a son with autism, and I was texting him 525 00:30:56,080 --> 00:30:58,080 Speaker 1: about this, and it's like, man, there's a lot of 526 00:30:58,080 --> 00:31:01,120 Speaker 1: really interesting research. And asked him about his son having 527 00:31:01,200 --> 00:31:04,240 Speaker 1: g I issues and he said since day one, literally, 528 00:31:04,920 --> 00:31:07,080 Speaker 1: And you know, I was like, you're gonna really dig this. 529 00:31:07,160 --> 00:31:09,120 Speaker 1: He's a listener to so it's like, you're gonna really 530 00:31:09,160 --> 00:31:11,720 Speaker 1: dig this episode. I said. There, they've come a long way, 531 00:31:11,760 --> 00:31:13,800 Speaker 1: I said, and you know that the future looks bright 532 00:31:13,840 --> 00:31:18,120 Speaker 1: for you know, helping to mitigate maybe some symptoms. Yeah, 533 00:31:18,280 --> 00:31:21,080 Speaker 1: there seems to be treatable. Leaky gut seems to be 534 00:31:21,080 --> 00:31:26,040 Speaker 1: a treatable thing where it's probably the result of UH 535 00:31:26,200 --> 00:31:31,200 Speaker 1: dis biotic um microbiota um and that if you you know, 536 00:31:31,360 --> 00:31:36,000 Speaker 1: introduce certain kinds of um of bacteria that you want 537 00:31:36,280 --> 00:31:41,000 Speaker 1: that's missing. It may actually alleviate symptoms. Um. Again, I 538 00:31:41,040 --> 00:31:43,400 Speaker 1: don't think anybody's saying like you can cure autism just 539 00:31:43,440 --> 00:31:49,680 Speaker 1: with probiotics, but it's possible that that probiotics could really change, um, 540 00:31:49,840 --> 00:31:52,360 Speaker 1: somebody with autisms life for the better in a lot 541 00:31:52,440 --> 00:31:56,760 Speaker 1: of ways just from a probiotics supplement. And so there's 542 00:31:56,760 --> 00:32:00,840 Speaker 1: a bunch of companies apparently, uh, they're just growing. Vential 543 00:32:00,920 --> 00:32:03,920 Speaker 1: capitalists are just throwing money at any company working on 544 00:32:03,960 --> 00:32:07,840 Speaker 1: this right now. They're called psychobiotics. Um. This idea that 545 00:32:08,160 --> 00:32:11,360 Speaker 1: you can create like a probiotic cocktail to treat something 546 00:32:11,440 --> 00:32:15,960 Speaker 1: like autism or multiple sc sclerosis or or rheumatoid arthritis, 547 00:32:16,200 --> 00:32:19,720 Speaker 1: and that you don't have to use pharmaceuticals or drugs 548 00:32:19,760 --> 00:32:22,960 Speaker 1: that function in ways we don't really understand that what 549 00:32:23,000 --> 00:32:25,440 Speaker 1: you're doing is going to the bacteria and saying here, 550 00:32:25,840 --> 00:32:29,000 Speaker 1: live here and do your natural thing and produce this 551 00:32:29,080 --> 00:32:32,200 Speaker 1: stuff that this patient isn't producing on their own, won't you? 552 00:32:32,720 --> 00:32:37,400 Speaker 1: And that's just the most substantial way you can think 553 00:32:37,440 --> 00:32:42,360 Speaker 1: of to treat something like that. Super substantial, super substantial. 554 00:32:43,240 --> 00:32:46,360 Speaker 1: All right, Well, let's take our second break and we 555 00:32:46,480 --> 00:32:49,320 Speaker 1: will come back and wrap this puppy upright after this 556 00:32:51,640 --> 00:33:21,520 Speaker 1: kind of huge sk So back to the autism spectrum disorder. Uh. 557 00:33:21,560 --> 00:33:23,920 Speaker 1: They have found that this is about ten years ago. 558 00:33:24,680 --> 00:33:28,800 Speaker 1: They found a correlation between mothers who had a high 559 00:33:29,600 --> 00:33:32,880 Speaker 1: uh sort of long term, prolonged fever during pregnancy that 560 00:33:32,920 --> 00:33:35,560 Speaker 1: they were seven times more likely to give birth to 561 00:33:35,600 --> 00:33:39,720 Speaker 1: a baby who had symptoms of a s D. Again 562 00:33:39,800 --> 00:33:43,400 Speaker 1: correlation uh. And then again the mice come into play. 563 00:33:43,440 --> 00:33:46,120 Speaker 1: They got these pregnant mice, they infected them with a 564 00:33:46,160 --> 00:33:51,640 Speaker 1: flu virus. Uh, it's just poor mice, and they caused 565 00:33:52,000 --> 00:33:55,360 Speaker 1: a spiking fever and they gave birth to babies. And 566 00:33:56,240 --> 00:33:59,080 Speaker 1: they can't test baby mice for autism, but what they 567 00:33:59,080 --> 00:34:02,840 Speaker 1: can do is study their patterns and their behaviors. And 568 00:34:02,880 --> 00:34:06,600 Speaker 1: they did find that they had limited social interactions, they 569 00:34:06,600 --> 00:34:11,160 Speaker 1: had decreased vocalizations, they were doing repeated behaviors, they had 570 00:34:11,239 --> 00:34:14,080 Speaker 1: leaky bowels, some of the things that you might experience 571 00:34:14,480 --> 00:34:18,040 Speaker 1: on the autism spectrum disorder. Right, So they kind of 572 00:34:18,080 --> 00:34:21,120 Speaker 1: trace that to this idea, this theory, and there's a 573 00:34:21,120 --> 00:34:25,160 Speaker 1: bunch of theories about how people might develop autism, but 574 00:34:25,280 --> 00:34:29,440 Speaker 1: this idea that um, when the mom has a fever UH, 575 00:34:29,520 --> 00:34:33,279 Speaker 1: an immune response is activated by a gut micro a 576 00:34:33,320 --> 00:34:38,160 Speaker 1: particular one called segmented filamentous bacteria, and that it gets 577 00:34:38,280 --> 00:34:41,439 Speaker 1: uh T cells and cytokines active. Remember we talked about 578 00:34:41,440 --> 00:34:45,279 Speaker 1: cytokines in the m r n A episode and they 579 00:34:45,320 --> 00:34:48,360 Speaker 1: are helpful, but they can also overblow things quite a 580 00:34:48,360 --> 00:34:50,759 Speaker 1: bit because they run around activating all sorts of other 581 00:34:50,960 --> 00:34:54,719 Speaker 1: immune cells UM and basically say go, go go. And 582 00:34:54,760 --> 00:34:59,600 Speaker 1: so the idea is that this triggers inflammation, and inflammation 583 00:34:59,600 --> 00:35:02,080 Speaker 1: seems to a huge problem for all sorts of things, 584 00:35:02,080 --> 00:35:07,320 Speaker 1: everything from neurological disorders to um to arthritis, to UH 585 00:35:07,480 --> 00:35:10,560 Speaker 1: irritable bowel syndrome to to basically anything that can be 586 00:35:10,600 --> 00:35:13,520 Speaker 1: wrong with you seems to have some sort of basis 587 00:35:13,520 --> 00:35:16,520 Speaker 1: and inflammation, like your body's mounting in immune response and 588 00:35:16,560 --> 00:35:19,279 Speaker 1: you're suffering as a result. And so that's what the 589 00:35:19,320 --> 00:35:23,520 Speaker 1: idea is with this, that these UM cytokines actually travel 590 00:35:23,719 --> 00:35:27,600 Speaker 1: through the placenta and have an impact on the neurodevelopment 591 00:35:27,800 --> 00:35:31,239 Speaker 1: of the fetus, and that that is what causes autism UM. 592 00:35:31,400 --> 00:35:34,040 Speaker 1: So that it's traced back to this the to the 593 00:35:34,080 --> 00:35:38,520 Speaker 1: guts ability to trigger the immune system, which is another 594 00:35:38,600 --> 00:35:42,680 Speaker 1: whole thing that has you know, it has even wider 595 00:35:42,719 --> 00:35:47,600 Speaker 1: implications than UM than autism spectrum disorder to like, it 596 00:35:47,680 --> 00:35:50,640 Speaker 1: can trigger all sorts of other problems. UM. It might 597 00:35:50,680 --> 00:35:52,719 Speaker 1: not even have to do with the developing fetus. It 598 00:35:52,760 --> 00:35:56,200 Speaker 1: can happen within you, like it can cause UM cytokines 599 00:35:56,239 --> 00:36:00,000 Speaker 1: to to travel up to your brain and produce neurological disorders, 600 00:36:00,040 --> 00:36:02,440 Speaker 1: and you as well mental health issues. And you as 601 00:36:02,440 --> 00:36:06,920 Speaker 1: well that that the gut and inflammation happening in a 602 00:36:06,960 --> 00:36:10,400 Speaker 1: bad combo is is nade good for the average human. 603 00:36:10,520 --> 00:36:15,560 Speaker 1: They're finding, that's right. You mentioned psychobiotics before the break. 604 00:36:16,440 --> 00:36:20,320 Speaker 1: This is the idea that you can again use something 605 00:36:20,400 --> 00:36:26,399 Speaker 1: like probiotics to treat anxiety or depression. And uh they 606 00:36:26,440 --> 00:36:30,280 Speaker 1: have had a little bit of um good fortune with 607 00:36:30,280 --> 00:36:33,839 Speaker 1: with the results here, and it looks like, I mean, 608 00:36:33,880 --> 00:36:35,440 Speaker 1: they're doing some of this on humans, a lot of 609 00:36:35,440 --> 00:36:37,520 Speaker 1: those in rats. I think in two thousand eleven they 610 00:36:37,600 --> 00:36:41,239 Speaker 1: studied both rats and humans and they gave them uh 611 00:36:41,480 --> 00:36:46,640 Speaker 1: strains of bacteria for about thirty days, lacto Bacillus helveticus 612 00:36:47,280 --> 00:36:51,920 Speaker 1: and UH Beefidobe that's the same one from before the 613 00:36:52,040 --> 00:36:57,960 Speaker 1: feto Bacterium long hum. They should just name these, Yeah, 614 00:36:58,000 --> 00:37:01,400 Speaker 1: exactly this column by their pet name, like Lacto and Biff, 615 00:37:02,440 --> 00:37:05,359 Speaker 1: those two old friends. It's right, they really are too. 616 00:37:05,440 --> 00:37:07,680 Speaker 1: They seem to. They pop up a lot where it's like, no, 617 00:37:08,040 --> 00:37:09,440 Speaker 1: this is what you want. Like if you look at 618 00:37:09,440 --> 00:37:13,600 Speaker 1: probiotic supplements almost across the board, you're gonna find Lacto 619 00:37:13,719 --> 00:37:16,200 Speaker 1: and Biff in there. Yeah, Lacto and Biff, the two, 620 00:37:16,360 --> 00:37:18,959 Speaker 1: the two we love to eat. But they've then put 621 00:37:19,000 --> 00:37:22,560 Speaker 1: these people and mice through stress test and found a 622 00:37:22,680 --> 00:37:26,000 Speaker 1: quote significant reduction and anxiety like behavior in the rats 623 00:37:26,800 --> 00:37:31,560 Speaker 1: and actual psychological UM distress was being alleviated in humans 624 00:37:31,600 --> 00:37:34,600 Speaker 1: as well. Yeah, I mean there's that there. This is 625 00:37:34,640 --> 00:37:37,480 Speaker 1: where we're we're what we're moving towards now is treating 626 00:37:38,000 --> 00:37:43,160 Speaker 1: mood disorders, neurological disorders, mental health issues, UM, a whole 627 00:37:43,320 --> 00:37:49,320 Speaker 1: host of physical maladies, chronic diseases UM with with probiotics. 628 00:37:49,360 --> 00:37:52,760 Speaker 1: If you can figure out what's missing in these patients, 629 00:37:53,080 --> 00:37:56,400 Speaker 1: then you can grow that bacteria and put them in 630 00:37:56,440 --> 00:37:59,600 Speaker 1: the person through like pills, and it's possible they'll clear 631 00:37:59,600 --> 00:38:03,239 Speaker 1: it up. Another UM theory of where autism comes from 632 00:38:03,360 --> 00:38:06,440 Speaker 1: is that there's a depleted gut where there's there's bacteria 633 00:38:06,480 --> 00:38:09,000 Speaker 1: that's missing from the person. And they found in my 634 00:38:09,200 --> 00:38:12,200 Speaker 1: studies they are able to produce germ free mice chuck 635 00:38:12,800 --> 00:38:15,680 Speaker 1: and they they those germ free mice tend to exhibit 636 00:38:15,719 --> 00:38:20,640 Speaker 1: the autistic um uh symptoms. Um that when they treat 637 00:38:20,719 --> 00:38:24,759 Speaker 1: them with with probiotics, that those autistic symptoms tend to 638 00:38:24,800 --> 00:38:29,520 Speaker 1: clear up, which is pretty amazing. Yeah, it almost it 639 00:38:29,560 --> 00:38:32,399 Speaker 1: doesn't almost seem like like what is definitely happening. As 640 00:38:32,440 --> 00:38:35,399 Speaker 1: science has progressed over the years, it feels like it's 641 00:38:35,440 --> 00:38:40,120 Speaker 1: become way way less segmented. Um, it's like, here's here's 642 00:38:40,120 --> 00:38:42,080 Speaker 1: your brain, and here's your nervous system, and here's your 643 00:38:42,160 --> 00:38:45,520 Speaker 1: organs and here's this stuff, and it's all compartmentalized, and 644 00:38:46,040 --> 00:38:48,720 Speaker 1: it just seems like through our own research over the years, 645 00:38:49,640 --> 00:38:52,719 Speaker 1: everything is linked together. It seems like, yeah, there's a 646 00:38:52,719 --> 00:38:56,240 Speaker 1: whole um, a whole field called functional medicine that's developing 647 00:38:56,280 --> 00:39:01,600 Speaker 1: that gets super poop pooed by skeptics, and um, it's understandable. 648 00:39:01,600 --> 00:39:03,440 Speaker 1: It's a very early field and there are plenty of 649 00:39:03,480 --> 00:39:06,959 Speaker 1: practitioners who overdo it in in what they say that 650 00:39:06,960 --> 00:39:09,840 Speaker 1: that can be accomplished, But the the whole idea behind 651 00:39:09,880 --> 00:39:12,160 Speaker 1: it is is it's integrated with another name for it 652 00:39:12,200 --> 00:39:16,000 Speaker 1: is integrative medicine. Where, um, you you don't like one 653 00:39:16,000 --> 00:39:17,920 Speaker 1: of the first things you would do when somebody came 654 00:39:17,960 --> 00:39:20,480 Speaker 1: in with a problem, no matter what it was, adjust 655 00:39:20,480 --> 00:39:24,480 Speaker 1: their diet to a healthier diet and start there. Because 656 00:39:24,600 --> 00:39:28,000 Speaker 1: this idea of like the there's your part of a big, 657 00:39:28,080 --> 00:39:31,480 Speaker 1: interconnected whole, that that's how our bodies function. Um, it 658 00:39:31,520 --> 00:39:34,759 Speaker 1: seems intuitive to me now, you know. Yeah, I mean 659 00:39:34,800 --> 00:39:38,440 Speaker 1: Emily goes to a functional medicine doctor, uh, in addition 660 00:39:38,480 --> 00:39:41,680 Speaker 1: to our our regular m d um. It's it's sort 661 00:39:41,719 --> 00:39:42,800 Speaker 1: of it doesn't have to be a one or the 662 00:39:42,840 --> 00:39:47,200 Speaker 1: other thing. Ideally, I don't ideally they worked not together together, 663 00:39:47,280 --> 00:39:50,720 Speaker 1: but they won't even speak to one another. But as 664 00:39:50,760 --> 00:39:53,800 Speaker 1: a patient, ideally they worked. You can work with both, 665 00:39:54,000 --> 00:39:56,160 Speaker 1: is what I'm saying. Yeah, you just don't tell them 666 00:39:56,160 --> 00:40:00,000 Speaker 1: about each other. She is as as you know, is uh, 667 00:40:00,200 --> 00:40:04,040 Speaker 1: suffering through lime right now. I didn't know that. Oh no, oh, 668 00:40:04,080 --> 00:40:07,319 Speaker 1: I didn't tell you that. No, man, that's terrible. Yeah, 669 00:40:07,400 --> 00:40:11,120 Speaker 1: it's been a bad scene at the house for a while. Uh, 670 00:40:11,520 --> 00:40:14,120 Speaker 1: but her her diet is one of the big She's 671 00:40:14,160 --> 00:40:21,000 Speaker 1: on this crazy weird awful diet, nothing but goat milk. No, 672 00:40:21,200 --> 00:40:26,440 Speaker 1: but lots of weird like forest floor tea and just 673 00:40:26,560 --> 00:40:29,680 Speaker 1: stuff that you know, not able to eat. I mean 674 00:40:29,719 --> 00:40:32,520 Speaker 1: you name it. Man, So many things that she can't 675 00:40:32,640 --> 00:40:36,399 Speaker 1: have right now. Uh, to try and help it out 676 00:40:36,400 --> 00:40:39,279 Speaker 1: because you know, the antibiotics they put her on, we're 677 00:40:39,360 --> 00:40:42,239 Speaker 1: wrecking her. Well. Yeah, that's another thing too, is they're 678 00:40:42,239 --> 00:40:45,640 Speaker 1: figuring out that antibiotics to treat just you know rando 679 00:40:45,800 --> 00:40:48,840 Speaker 1: stuff or like the flu or something like that, that 680 00:40:48,840 --> 00:40:51,279 Speaker 1: that can have a huge, terrible effect on your gut 681 00:40:51,320 --> 00:40:55,040 Speaker 1: chemistry and can have cascading effects down the road. There's there. 682 00:40:55,120 --> 00:40:56,800 Speaker 1: That's say, another thing that they're just kind of in 683 00:40:56,840 --> 00:40:59,080 Speaker 1: the initial studies of it. It's not not in any 684 00:40:59,080 --> 00:41:02,320 Speaker 1: shade on antibio aotics. They basically have saved more lives 685 00:41:02,360 --> 00:41:05,319 Speaker 1: than can be possibly counted, but that but we have 686 00:41:05,480 --> 00:41:09,520 Speaker 1: tended to kind of lean toward prescribing them willy nilly, 687 00:41:09,560 --> 00:41:12,759 Speaker 1: and people don't finish their their prescription anyway. So there's 688 00:41:12,760 --> 00:41:14,560 Speaker 1: all sorts of problems with it. But they're finding like 689 00:41:14,560 --> 00:41:17,239 Speaker 1: there's a lot of less less than obvious problems that 690 00:41:17,280 --> 00:41:21,160 Speaker 1: can come about from killing off your gut microbiome. Totally. 691 00:41:21,920 --> 00:41:23,600 Speaker 1: So there's one last thing I want to end with 692 00:41:23,680 --> 00:41:25,799 Speaker 1: real quick, Chuck. One of the guys, the guy who 693 00:41:25,840 --> 00:41:29,120 Speaker 1: actually um along with it, a guy named Ted Deanan, 694 00:41:29,280 --> 00:41:33,440 Speaker 1: coined the term psychobiotics and psychobiome, which is a description 695 00:41:33,480 --> 00:41:37,160 Speaker 1: of how your microbiome produces neurotransmitters like serotonin and dopamine 696 00:41:37,160 --> 00:41:40,240 Speaker 1: and all that that. Um. His his name is John Crying, 697 00:41:40,640 --> 00:41:44,759 Speaker 1: and he has a theory of why, uh, we would 698 00:41:44,760 --> 00:41:49,360 Speaker 1: have evolved to have a microbiome that would impact whether 699 00:41:49,400 --> 00:41:51,600 Speaker 1: we're social or not, because it's weird if you think 700 00:41:51,600 --> 00:41:55,719 Speaker 1: about it. Why would your your gut microbio biome b 701 00:41:56,320 --> 00:42:03,560 Speaker 1: being off like this biotic have any impact done social socialization? Right? Yeah, 702 00:42:03,640 --> 00:42:05,560 Speaker 1: I mean this is super interesting. And the Ted talk 703 00:42:05,680 --> 00:42:09,200 Speaker 1: is uh, it's a Ted med It's it's awesome if 704 00:42:09,200 --> 00:42:11,680 Speaker 1: you have time to go watch it. A little heavy, 705 00:42:11,719 --> 00:42:15,080 Speaker 1: but good stuff. Um. His theory he basically studied the 706 00:42:15,160 --> 00:42:17,520 Speaker 1: same germ free mice that you were talking about that 707 00:42:17,719 --> 00:42:20,239 Speaker 1: have they basically don't have a microbioma of their own. 708 00:42:21,160 --> 00:42:23,640 Speaker 1: Very sad uh, and he's he found out that these 709 00:42:23,640 --> 00:42:27,480 Speaker 1: germ free mice showed a lot of social impairment, especially 710 00:42:27,520 --> 00:42:31,239 Speaker 1: the male mice, and He compared that to the uh 711 00:42:32,080 --> 00:42:35,000 Speaker 1: GERM free mice two symptoms of a s D and 712 00:42:35,200 --> 00:42:38,040 Speaker 1: found that it also affected males. So again that got 713 00:42:38,080 --> 00:42:40,160 Speaker 1: him thinking kind of like what's going on with this stuff? 714 00:42:40,880 --> 00:42:45,239 Speaker 1: So he said, I wonder if like having a healthy, 715 00:42:45,280 --> 00:42:49,759 Speaker 1: sociable human is dependent on that gut bacteria, with the 716 00:42:49,800 --> 00:42:53,880 Speaker 1: idea being that we're all hanging out together in groups, 717 00:42:54,120 --> 00:42:56,680 Speaker 1: you know, tuk tuk in the gang, and we're trading 718 00:42:56,719 --> 00:42:59,839 Speaker 1: bacteria with one another. We're in close contact with one 719 00:42:59,840 --> 00:43:02,359 Speaker 1: and other and swapp and spit with one another, so 720 00:43:02,480 --> 00:43:05,920 Speaker 1: our bacteria is more varied basically, and that's how it's 721 00:43:05,960 --> 00:43:08,560 Speaker 1: selecting that as a positive trade. Yeah, And from the 722 00:43:08,640 --> 00:43:12,080 Speaker 1: bacteria standpoint, the more humans there are around, the more 723 00:43:12,160 --> 00:43:16,759 Speaker 1: hosts you have to colonize, the more the bacteria species thrives. Right, 724 00:43:17,360 --> 00:43:20,759 Speaker 1: So it's like, uh, it's beneficial either way. Like we 725 00:43:20,840 --> 00:43:23,840 Speaker 1: actually get a lot out of being social, Like we 726 00:43:23,960 --> 00:43:26,760 Speaker 1: have longer lifespans, we have a better outlook on life, 727 00:43:26,800 --> 00:43:30,000 Speaker 1: the more like close friends and support network we have. 728 00:43:30,080 --> 00:43:32,960 Speaker 1: It's just been documented over and over again, and it 729 00:43:33,120 --> 00:43:35,360 Speaker 1: seems to be like the more we look into the 730 00:43:35,440 --> 00:43:40,040 Speaker 1: microbiome and the psychobiome that that is driven by bacteria 731 00:43:40,120 --> 00:43:44,400 Speaker 1: that seem to make us more social through their byproducts 732 00:43:44,400 --> 00:43:47,000 Speaker 1: that they make that travel to our brain. Is that 733 00:43:47,080 --> 00:43:50,600 Speaker 1: circular loop again? Yeah? Yeah, so win win is another 734 00:43:50,640 --> 00:43:53,200 Speaker 1: way to put it, and I love them. Uh, you 735 00:43:53,280 --> 00:43:57,920 Speaker 1: got anything else for now? Nothing that's super significant? Okay, Well, 736 00:43:57,960 --> 00:43:59,960 Speaker 1: if you want to know more about the psychobiomego why 737 00:44:00,520 --> 00:44:04,040 Speaker 1: John Crying's Ted med Talk and also UM check out 738 00:44:04,239 --> 00:44:08,280 Speaker 1: on Science the Journal Sciences website, Meet the psycho Biome. 739 00:44:08,480 --> 00:44:11,759 Speaker 1: It's a really good introduction to UM. And since I 740 00:44:11,760 --> 00:44:14,480 Speaker 1: said it's a really good introduction too, it's time for 741 00:44:14,480 --> 00:44:21,560 Speaker 1: a listener mail. I'm gonna call this from listeners in 742 00:44:21,600 --> 00:44:23,120 Speaker 1: the in their seventies. We love to hear from our 743 00:44:23,200 --> 00:44:27,080 Speaker 1: listeners that are even older than me. It makes me 744 00:44:27,120 --> 00:44:30,680 Speaker 1: feel good. Hey, guys, my wife and I love your podcast, 745 00:44:30,719 --> 00:44:31,920 Speaker 1: and this I think is just a bit of a 746 00:44:31,960 --> 00:44:35,920 Speaker 1: reminder for us. I've been listening UM for years now 747 00:44:35,960 --> 00:44:40,560 Speaker 1: every afternoon while playing Spite and Malice. Do you know 748 00:44:40,600 --> 00:44:42,640 Speaker 1: what that is? It sounded really familiar and I didn't 749 00:44:42,640 --> 00:44:44,360 Speaker 1: have time to look it up because that emails just 750 00:44:44,480 --> 00:44:47,080 Speaker 1: came in right. Yeah, this is hot off the precess. 751 00:44:47,880 --> 00:44:49,759 Speaker 1: We're both in our seventies and love learning things we 752 00:44:49,800 --> 00:44:52,120 Speaker 1: still don't know. But this email is to mention to 753 00:44:52,200 --> 00:44:56,200 Speaker 1: both of you lately that your childhood vocal or religious 754 00:44:56,239 --> 00:45:01,280 Speaker 1: vocabulary his upticks some just reminding you that young people 755 00:45:01,719 --> 00:45:05,720 Speaker 1: around the world are listening and the word use brain 756 00:45:05,760 --> 00:45:10,920 Speaker 1: framing is occurring bigly. We suggest for your consideration to 757 00:45:10,960 --> 00:45:15,040 Speaker 1: stay with secular language like CE for the current era. Uh. 758 00:45:15,160 --> 00:45:17,279 Speaker 1: We used, we used to DeVault the CE. I guess 759 00:45:17,320 --> 00:45:20,160 Speaker 1: we kind of have flap back a little bit. Heavin'tly. 760 00:45:20,320 --> 00:45:22,960 Speaker 1: I hadn't noticed. I wonder if we didn't in the 761 00:45:23,000 --> 00:45:25,799 Speaker 1: folklore episode because they were just referenced folklore and we 762 00:45:25,880 --> 00:45:29,680 Speaker 1: just ran the folklore select recently, so maybe they're maybe 763 00:45:29,719 --> 00:45:36,040 Speaker 1: they're thinking, like that's a current episode. Oh that's my guess. Okay, 764 00:45:36,080 --> 00:45:38,320 Speaker 1: it's your guess, is that we're on it. I feel 765 00:45:38,360 --> 00:45:41,000 Speaker 1: like we're on it. I didn't. I hadn't noticed anything 766 00:45:41,040 --> 00:45:44,400 Speaker 1: like that. I feel like we've said BC recently. I 767 00:45:44,440 --> 00:45:49,000 Speaker 1: think you're talking about the headache powder, Okay, which I love. 768 00:45:49,719 --> 00:45:52,359 Speaker 1: We suggest you use secular language like CE for this 769 00:45:52,840 --> 00:45:56,600 Speaker 1: current era. For example, and explaining historical timelines and science 770 00:45:56,719 --> 00:46:01,160 Speaker 1: miracles or humicles as we call them. Uh, and science 771 00:46:01,239 --> 00:46:03,200 Speaker 1: is miraculous in its own right, with all credits to the 772 00:46:03,160 --> 00:46:06,640 Speaker 1: the amazing human beings who discover the actuality of our 773 00:46:06,719 --> 00:46:09,399 Speaker 1: natural universe. Thanks for what you do, keep them coming. 774 00:46:09,800 --> 00:46:13,600 Speaker 1: This is from Andre and Meredith Ryland in Pensacola, Florida. 775 00:46:13,960 --> 00:46:16,720 Speaker 1: Thanks a lot, Andrea and Meredith. We appreciate you guys 776 00:46:16,760 --> 00:46:18,680 Speaker 1: writing in and if you want to be like those 777 00:46:18,719 --> 00:46:21,880 Speaker 1: two and write in yourself, well we want to hear it. 778 00:46:22,280 --> 00:46:25,680 Speaker 1: Send us an email to Stuff podcast at i heeart 779 00:46:25,760 --> 00:46:31,400 Speaker 1: radio dot com. Stuff you Should Know is a production 780 00:46:31,440 --> 00:46:34,400 Speaker 1: of I Heart Radio. For more podcasts my heart Radio, 781 00:46:34,600 --> 00:46:37,719 Speaker 1: visit the iHeart Radio app, Apple Podcasts, or wherever you 782 00:46:37,760 --> 00:46:39,040 Speaker 1: listen to your favorite shows.