WEBVTT - Ep 65 Sweating Sickness: Ready, Sweat, Go!

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<v Speaker 1>In this same year, a new kind of sickness came

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<v Speaker 1>suddenly through the whole region, even after the first entering

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<v Speaker 1>of the King into this aisle, which was so sore,

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<v Speaker 1>so painful, and sharp, that the like was never heard

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<v Speaker 1>of to any man's remembrance before that time. For suddenly

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<v Speaker 1>a deadly and burning sweat invaded their bodies and vexed

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<v Speaker 1>their blood, and with a most ardent heat, infested the

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<v Speaker 1>stomach and the head. Grievously. By the tormenting and vexation

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<v Speaker 1>of which sickness, men were so sore, handled and so

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<v Speaker 1>painfully pained, that if they were laid in their bed,

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<v Speaker 1>being not able to suffer the importunate heat, they cast

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<v Speaker 1>away the sheets and all the clothes lying on the bed.

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<v Speaker 1>If they were in their apparel and vestures, they would

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<v Speaker 1>put off all their garments, even to their shirts. Others

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<v Speaker 1>were so dry that they drank the cold water to

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<v Speaker 1>quench their importunate heat and insatiable thirst. Others that could

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<v Speaker 1>or at the least wood, abide the heat and stink.

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<v Speaker 1>For indeed the sweat had a great and strong caused

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<v Speaker 1>clothes to be laid upon them as much as they

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<v Speaker 1>could bear to drive out the sweat, if it might

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<v Speaker 1>be all in manner, as soon as the sweat took them,

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<v Speaker 1>or within a short space after yielded up their ghost,

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<v Speaker 1>so that of all of them that sickened, there was

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<v Speaker 1>not one amongst a hundred that escaped, insomuch that, beside

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<v Speaker 1>the great number which deceased. Within the city of London,

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<v Speaker 1>two mayors successively died of the same disease within eight days,

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<v Speaker 1>and six aldermen. And when any person had fully and

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<v Speaker 1>completely sweat twenty four hours, for so long did the

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<v Speaker 1>strength of this plague hold them, he should be then

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<v Speaker 1>clearly delivered of his disease, yet not so clean rid

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<v Speaker 1>of it, but that he might shortly relapse and fall

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<v Speaker 1>again into the same evil pit. Yeay again, and twice again,

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<v Speaker 1>as many a one indeed did, which after the third

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<v Speaker 1>time died of the same.

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<v Speaker 2>Huh. I was trying to like listen for clues. And

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<v Speaker 2>this is gonna be a fun episode, Aarin, It.

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<v Speaker 1>Is gonna be a very fun episode. I am so excited.

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<v Speaker 1>So that was a contemporary account of the sweating sickness.

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<v Speaker 1>I'm not sure actually which epidemic, but I found it

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<v Speaker 1>in a paper by flood from two thousand and three. Hi,

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<v Speaker 1>I'm Aaron Welsh.

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<v Speaker 2>And I'm Erin Ollman Updyke.

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<v Speaker 1>And this is this podcast Will Kill You.

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<v Speaker 2>And today we're talking about sweating sickness.

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<v Speaker 1>Sweating sickness it is. I'm like so excited because a

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<v Speaker 1>lot of people have suggested this over the years as

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<v Speaker 1>we've been doing this podcast, and I was like, okay, yeah,

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<v Speaker 1>that sounds really interesting. And I was like, yeah, I

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<v Speaker 1>know about sweating sickness, like you know, people sweat and

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<v Speaker 1>they died and that was it. And then like I

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<v Speaker 1>started to read more about it and I was like, what, I'm.

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<v Speaker 2>Excited because I know literally nothing about it. Like when

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<v Speaker 2>people have suggested it, I've been like, okay, yeah, sure,

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<v Speaker 2>I have no idea what it is.

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<v Speaker 1>I am very excited. So the way that we did

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<v Speaker 1>this episode, and I think it's like the way that

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<v Speaker 1>we did the dancing plague episode, Yeah, is where I

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<v Speaker 1>like research the historical epidemics. And by the way, sweating

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<v Speaker 1>sickness is a mystery, so this is like a mysterious

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<v Speaker 1>epidemic episode.

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<v Speaker 2>Right, It's going to be like our encephalitis lethargica and

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<v Speaker 2>our dancing plague episode. So a little different than tradition.

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<v Speaker 1>Yeah, and so yeah, I did all the research for

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<v Speaker 1>like the history of it as usual, but instead of

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<v Speaker 1>of Aaron taking on, oh, this is the biological cause

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<v Speaker 1>and the epidemiology of it, I was like, hey, research

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<v Speaker 1>these five things that people think it was right, and.

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<v Speaker 2>So then we'll go through them and look at the

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<v Speaker 2>biology of these you know, possible explanations and try and

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<v Speaker 2>figure out what we think.

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<v Speaker 1>Yeah, yeah, I mean I think this will kind of

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<v Speaker 1>be like an episode of Unsolved Mysteries where you're like, oh,

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<v Speaker 1>this is so exciting, like what's going to happen, what's

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<v Speaker 1>going to happen, and then ultimately like you're not really

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<v Speaker 1>going to get a very fully satisfying answer.

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<v Speaker 2>Do you mean you think that, like, because this has

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<v Speaker 2>been how many hundreds of years that we have yet

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<v Speaker 2>to figure out exactly what caused it? You don't think

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<v Speaker 2>we're gonna solve it on this podcast today?

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<v Speaker 1>We're not. I mean I feel like with some exhumations

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<v Speaker 1>of some royal bodies or something and then testing some DNA,

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<v Speaker 1>that is possible, but also yeah, that has like not

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<v Speaker 1>that has been tried, and no permission has ever been granted.

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<v Speaker 2>So well, yeah, all right, we'll do our best.

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<v Speaker 1>We'll do our best, so Aaron, Yeah, it's a very

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<v Speaker 1>special time.

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<v Speaker 2>It is. I checked, it is quarantin any time.

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<v Speaker 1>It is quarantiny time. This week we are drinking sweat

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<v Speaker 1>it out, Sweat it out, and in sweat it out

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<v Speaker 1>is it's going to be like a little bit of

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<v Speaker 1>a spicy and smoky situation of course to.

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<v Speaker 2>Like really give you that sheen exactly.

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<v Speaker 1>We want you to. We want to see those beads

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<v Speaker 1>of perspiration on your dewey forehead. We have mes call

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<v Speaker 1>lime juice, Habanero, simple syrup, mango juice, and orange liqueur yum.

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<v Speaker 2>And we will post the full recipe for that quarantini

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<v Speaker 2>as well as our non alcoholic place Brita on all

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<v Speaker 2>of our social media channels and this podcast will kill

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<v Speaker 2>you dot Com.

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<v Speaker 1>We will do.

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<v Speaker 2>We have any other business to talk about.

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<v Speaker 1>We do have one small piece of business. We have

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<v Speaker 1>a correction.

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<v Speaker 2>Actually yes we do so.

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<v Speaker 1>In our last episode, which was on Rubella, one of

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<v Speaker 1>the terms that we used was differently abled and a

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<v Speaker 1>bunch of people have reached out to let us know

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<v Speaker 1>that that is actually not the preferred term, and we

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<v Speaker 1>apologize for doing that, and we will do better in

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<v Speaker 1>the future.

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<v Speaker 2>Yeah, and thank you, honestly, thank you for pointing that

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<v Speaker 2>out and people pointing it out in a way that

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<v Speaker 2>makes it easy for us to learn, and so now

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<v Speaker 2>we can teach everyone else too. So the preferred term

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<v Speaker 2>is disabled, not differently able.

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<v Speaker 1>Yes, and we appreciate it. Do we have any other

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<v Speaker 1>business to take care of?

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<v Speaker 2>We have merch which is amazing created by incredible artists,

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<v Speaker 2>available on this podcast We Kill You dot Com. Under merch,

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<v Speaker 2>we have a bookshop link as well as a Goodreads

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<v Speaker 2>list if you're interested in finding or purchasing books that

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<v Speaker 2>we recommend on this podcast.

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<v Speaker 1>Ooh, and we're getting transcripts yay.

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<v Speaker 2>So you can read more. Yes, we're very excited. These

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<v Speaker 2>have been very long awaited and we'll be available on

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<v Speaker 2>this podcast We Kill You dot Com. Just click on transcripts.

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<v Speaker 2>We're super excited. Heck yeah, I think that's enough business.

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<v Speaker 1>Well, should we dive into this episode?

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<v Speaker 2>Erin, I can't wait. I really like, I'm not kidding

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<v Speaker 2>when I say I know nothing about sweating sickness and

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<v Speaker 2>I want to learn all about it.

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<v Speaker 1>Excellent, Well, I will dive right in right after this

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<v Speaker 1>break ready. Oh yeah, sweat go.

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<v Speaker 2>Oh erin.

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<v Speaker 1>I feel like planned and rehearse jokes are probably the best, right.

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<v Speaker 2>Definitely, yeah, absolutely, I mean I didn't see it coming.

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<v Speaker 1>Suntana is overrated, quick wit, absolutely not, who needs it? Okay?

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<v Speaker 1>But for real? The English sweating sickness was basically a

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<v Speaker 1>series of five epidemics occurring in fourteen eighty five, fifteen

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<v Speaker 1>oh eight, fifteen seventeen, fifteen twenty eight, and fifteen fifty one,

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<v Speaker 1>primarily in England and only England.

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<v Speaker 2>Huh.

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<v Speaker 1>Its entire history takes place within that not quite seventy

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<v Speaker 1>year timeframe. It caused nowhere near the same level of

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<v Speaker 1>population devastation that plague epidemics did. And and I'm not

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<v Speaker 1>talking just about the Black Death, but I mean the

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<v Speaker 1>outbreaks of plague that continued across England and the rest

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<v Speaker 1>of Europe for centuries after. And if it wasn't a

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<v Speaker 1>plague year, people were still no stranger to deadly illnesses

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<v Speaker 1>that would burn through a city or a village and

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<v Speaker 1>wipe out one side of a family tree within a

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<v Speaker 1>matter of days. Life was precarious. Death was all always

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<v Speaker 1>hovering at the edge. Hence, like all the rad metal

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<v Speaker 1>art from that time, all the skeletons. So with, so

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<v Speaker 1>with these epidemics of plague, typhoid, malaria, influenza, smallpox, et cetera,

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<v Speaker 1>constantly on rotation. What made sweating sickness so remarkable to

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<v Speaker 1>people in that time? What was it about sweating sickness

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<v Speaker 1>that led to such terror and panic that Henry the eighth,

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<v Speaker 1>for example, fled with his members of court to avoid

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<v Speaker 1>the sickness somewhat in vain, I might add, And what

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<v Speaker 1>is it about this mysterious yet very isolated and short

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<v Speaker 1>lived illness that still leads people in the twenty first century,

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<v Speaker 1>five hundred years later to talk about it, publish articles

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<v Speaker 1>about it, highlighted in novels and TV shows.

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<v Speaker 2>Let's find out, Yeah.

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<v Speaker 1>England in fourteen eighty five was at a bit of

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<v Speaker 1>a turning point, the War of the Roses finally drawing

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<v Speaker 1>to a close, with Richard the Third losing his life

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<v Speaker 1>and his army defeated at the decisive Battle of bosworth Field,

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<v Speaker 1>which led to Henry, Earl of Richmond taking the throne

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<v Speaker 1>as Henry the Seventh and kicking off a one hundred

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<v Speaker 1>and fifteen ish year rule by the House of Tudor

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<v Speaker 1>in England. Okay, and like all of that stuff about

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<v Speaker 1>the history of the English royal families and succession and

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<v Speaker 1>blah blah blah. I think is really interesting, but like

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<v Speaker 1>that's not what we do in this podcast. I'm not

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<v Speaker 1>equipped to do it, and so that's all I'm going

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<v Speaker 1>to say about that. But the reason that I mention

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<v Speaker 1>it is because the year fourteen eighty five was not

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<v Speaker 1>just this end of the War of the Roses. We

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<v Speaker 1>care about it because that's when we first see sweating sickness,

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<v Speaker 1>and the exact date within that year of the earliest

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<v Speaker 1>cases is a little bit controversial because some early chroniclers

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<v Speaker 1>claimed that it was brought over at the time of

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<v Speaker 1>the battle by Henry's French mercenaries, but that's actually unlikely

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<v Speaker 1>for a number of reasons, among them the fact that

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<v Speaker 1>there aren't any descriptions of this disease in France during

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<v Speaker 1>that time, and that there were sporadic cases reported elsewhere

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<v Speaker 1>in England prior to this battle, which took place in

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<v Speaker 1>late August August Okay, but where there may have been

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<v Speaker 1>scattered cases throughout England earlier in the summer of fourteen

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<v Speaker 1>eighty five. Later it had erupted into a full on outbreak.

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<v Speaker 1>In early September, the mysterious sweating sickness had spread to Oxford.

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<v Speaker 1>By late September, it had reached London, and by October

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<v Speaker 1>it was in most of the western and southern counties.

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<v Speaker 1>One contemporary chronicler reported that it had killed fifteen thousand

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<v Speaker 1>people in London, which is surely an exaggeration because that

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<v Speaker 1>would have been about a third of London's population at

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<v Speaker 1>the time, But that does just further illustrate the impression

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<v Speaker 1>that it left on the people who were witnessing this

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<v Speaker 1>illness sweep through and with this impression was just of

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<v Speaker 1>total helplessness and devastation. But what were they seeing? Yeah, Okay,

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<v Speaker 1>so I guess maybe before I go through the next

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<v Speaker 1>few epidemics, I should probably describe sweating sickness a little

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<v Speaker 1>more detail.

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<v Speaker 2>I am like on edge, right, you know, I can

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<v Speaker 2>tell you literally as you're talking, so that I can

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<v Speaker 2>try and figure out what's going on.

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<v Speaker 1>Okay, Okay, this is great because I get to pretend

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<v Speaker 1>to be you in this In this episode, it starts

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<v Speaker 1>with a fever.

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<v Speaker 2>With a fever.

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<v Speaker 1>Yes, I never get to say that, and it actually does.

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<v Speaker 1>It actually starts with a fever okay, cool, and it

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<v Speaker 1>comes on quickly. One minute, you're doing whatever it is

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<v Speaker 1>people were doing in England in the fourteen hundreds and

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<v Speaker 1>fifteen hundreds, like maybe you were rolling out some rye dough,

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<v Speaker 1>or you were tending to your crops, or you were

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<v Speaker 1>writing a sermon denounce it Martin Luther and his ninety

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<v Speaker 1>five THESS or whatever. Just casual, just cash stuff. And

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<v Speaker 1>the next minute you feel this slight fever coming on,

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<v Speaker 1>and along with that fever an intense sweat. Okay, this

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<v Speaker 1>isn't any old, heavy after workout type sweat. This is unprecedented,

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<v Speaker 1>not only because of the volume of moisture leaking from

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<v Speaker 1>your armpits and beating up all of your skin, but

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<v Speaker 1>also from the vile stench accompanying it. What fetid, corrupt, putrid,

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<v Speaker 1>loathsome These are just some of the words that contemporary

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<v Speaker 1>physicians or scholars use to describe this sweat.

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<v Speaker 2>Okay, but can I already take a time out and

0:14:41.800 --> 0:14:45.960
<v Speaker 2>ask a question? Of course, this is a Roles reversed sarre,

0:14:46.000 --> 0:14:51.080
<v Speaker 2>and now I know how you feel. Okay, are people stinking?

0:14:51.200 --> 0:14:53.560
<v Speaker 2>Like is it the sweat that is stinky or is

0:14:53.600 --> 0:14:55.800
<v Speaker 2>it just that like it's fourteen eighty five. People don't

0:14:55.840 --> 0:14:59.400
<v Speaker 2>have great hygiene, and so when you sweat, you smell yourself,

0:14:59.440 --> 0:15:02.200
<v Speaker 2>and so everyone's sweating, and so now they stink, Like

0:15:02.600 --> 0:15:05.840
<v Speaker 2>is it more stinky than other illness sweat? I'm confused.

0:15:06.080 --> 0:15:09.240
<v Speaker 1>Well, so I can't answer that except for the fact

0:15:09.280 --> 0:15:13.840
<v Speaker 1>that the horrible smell was noted in like all of

0:15:13.880 --> 0:15:17.400
<v Speaker 1>the descriptions, okay, which like would lead me to believe

0:15:17.440 --> 0:15:20.720
<v Speaker 1>that there is something special about this sweat, because how

0:15:20.760 --> 0:15:24.680
<v Speaker 1>do you avoid smelling yourself? Like you know, We'll bit.

0:15:24.680 --> 0:15:25.080
<v Speaker 1>I don't know.

0:15:25.360 --> 0:15:28.280
<v Speaker 2>I'm just going through what you asked me to research, Aaron,

0:15:28.320 --> 0:15:31.640
<v Speaker 2>and already I'm like, well, no idea.

0:15:32.640 --> 0:15:35.280
<v Speaker 1>I mean, maybe it is possible. Like so there are

0:15:35.360 --> 0:15:39.280
<v Speaker 1>some modern scholars that say, well, perhaps the excessive sweat

0:15:39.320 --> 0:15:43.360
<v Speaker 1>was due to anxiety, because the fever wasn't all that high,

0:15:43.440 --> 0:15:45.880
<v Speaker 1>it wasn't all that burning, or it didn't seem to

0:15:45.880 --> 0:15:48.320
<v Speaker 1>be It seemed like a slight fever, and so the

0:15:48.320 --> 0:15:52.120
<v Speaker 1>successive sweat seemed strange. But it also was incredibly notable,

0:15:52.200 --> 0:15:53.880
<v Speaker 1>like it was it's in the name.

0:15:54.040 --> 0:15:54.640
<v Speaker 2>It's in the name.

0:15:54.680 --> 0:15:58.000
<v Speaker 1>They called its sweating sickness. Yeah, so I can't answer

0:15:58.080 --> 0:16:00.160
<v Speaker 1>you about the smell part. But I would have to

0:16:00.160 --> 0:16:03.600
<v Speaker 1>believe that, like at a certain point you would have

0:16:03.720 --> 0:16:08.280
<v Speaker 1>gotten accustomed to how much you and everyone around you stank.

0:16:08.600 --> 0:16:11.520
<v Speaker 2>Right, and so then this is above and beyond fourteen

0:16:11.560 --> 0:16:12.960
<v Speaker 2>eighty five stink.

0:16:13.040 --> 0:16:16.120
<v Speaker 1>It seems to be. Okay, that's the sense I got

0:16:16.120 --> 0:16:21.680
<v Speaker 1>from this, right, Okay, Okay, So this sweating, which never

0:16:21.800 --> 0:16:27.200
<v Speaker 1>seems to cease, brings on an unquenchable thirst. Okay, your

0:16:27.240 --> 0:16:31.160
<v Speaker 1>heart starts racing, your back and arms and legs ache,

0:16:31.560 --> 0:16:35.000
<v Speaker 1>You feel stabbing pains in your stomach and bowels, and

0:16:35.120 --> 0:16:39.240
<v Speaker 1>oh my god, does your head hurt so badly that

0:16:39.320 --> 0:16:42.040
<v Speaker 1>you're having a hard time keeping a grasp on reality.

0:16:43.360 --> 0:16:45.480
<v Speaker 1>If you're lucky enough to have been close to home

0:16:45.520 --> 0:16:48.520
<v Speaker 1>when the symptoms began, you find yourself unable to crawl

0:16:48.520 --> 0:16:51.440
<v Speaker 1>out of bed. And if you weren't so lucky, you

0:16:51.560 --> 0:16:53.840
<v Speaker 1>lay on the ground where you stood when you first

0:16:53.880 --> 0:16:57.880
<v Speaker 1>felt the illness coming on. As you lay there, sweating

0:16:58.160 --> 0:17:04.040
<v Speaker 1>rancid sweat, guts oiling, body aching, head absolutely pounding, delirious,

0:17:04.640 --> 0:17:07.679
<v Speaker 1>your breathing starts to become more and more shallow, and

0:17:07.720 --> 0:17:11.919
<v Speaker 1>a great heaviness seems to settle on your chest. Maybe

0:17:11.960 --> 0:17:14.600
<v Speaker 1>you pile on more and more blankets or clothes to

0:17:14.640 --> 0:17:17.760
<v Speaker 1>try to keep the sweat in, which might have been

0:17:17.800 --> 0:17:22.320
<v Speaker 1>prescribed by your quote unquote doctor. Or you drink as

0:17:22.400 --> 0:17:25.560
<v Speaker 1>much lukewarm liquid as you can get down. But what

0:17:25.600 --> 0:17:28.400
<v Speaker 1>you really want to do, what your body really wants

0:17:28.400 --> 0:17:32.080
<v Speaker 1>you to do, is sleep, and so you close your

0:17:32.080 --> 0:17:35.479
<v Speaker 1>eyes and give in. But just like your insatiable thirst,

0:17:35.560 --> 0:17:38.280
<v Speaker 1>there never seems to be an amount of sleep that's

0:17:38.440 --> 0:17:41.760
<v Speaker 1>enough to make you feel rested. If you can endure

0:17:41.800 --> 0:17:45.960
<v Speaker 1>the first twenty four hours of this sweating, aching, burning, breathlessness,

0:17:46.240 --> 0:17:49.520
<v Speaker 1>you're probably in the clear. The relapses leading to death

0:17:49.560 --> 0:17:54.159
<v Speaker 1>were common, but according to writings from the time, few

0:17:54.320 --> 0:17:56.879
<v Speaker 1>escape the illness, and most succumb to death within a

0:17:56.920 --> 0:18:00.719
<v Speaker 1>few hours. A few hours of symptom on the set.

0:18:01.280 --> 0:18:03.120
<v Speaker 1>If you are well at lunch, you could be dead

0:18:03.119 --> 0:18:08.120
<v Speaker 1>by dinner quote But all alike died either as soon

0:18:08.160 --> 0:18:10.919
<v Speaker 1>as the fever began or not long after, so that

0:18:10.960 --> 0:18:13.800
<v Speaker 1>of all the persons infected, barely one in one hundred

0:18:13.880 --> 0:18:20.240
<v Speaker 1>escape death. Whoa The precise cause of death was unclear

0:18:20.680 --> 0:18:24.399
<v Speaker 1>still is unclear, but there are some isolated reports of

0:18:24.440 --> 0:18:28.760
<v Speaker 1>people recovering after being given an enema, which suggests along

0:18:28.800 --> 0:18:31.879
<v Speaker 1>with the list of symptoms, that severe dehydration may have

0:18:31.920 --> 0:18:33.040
<v Speaker 1>played a major role.

0:18:34.000 --> 0:18:36.160
<v Speaker 2>Okay, okay, okay, yeah, okay.

0:18:37.400 --> 0:18:42.520
<v Speaker 1>So now, after hearing this description of sweating sickness, which

0:18:42.560 --> 0:18:45.600
<v Speaker 1>I based off of a few contemporary accounts by Thomas

0:18:45.640 --> 0:18:48.760
<v Speaker 1>Forrest Jeer and John Keyes who lived through the fourteen

0:18:48.840 --> 0:18:53.920
<v Speaker 1>eighty five and fifteen fifty one epidemics, respectively, I think

0:18:54.040 --> 0:18:57.959
<v Speaker 1>we can mostly answer my earlier question as to why

0:18:58.000 --> 0:19:01.640
<v Speaker 1>sweating sickness left such an a depression on people at

0:19:01.640 --> 0:19:06.439
<v Speaker 1>that time, even though you know, epidemics of sweating sickness

0:19:06.440 --> 0:19:09.440
<v Speaker 1>were nearly as widespread or devastating as something like the plague.

0:19:10.400 --> 0:19:14.920
<v Speaker 1>This was a terrifying, rap and rapid disease that would

0:19:15.000 --> 0:19:16.440
<v Speaker 1>kill you within a few hours.

0:19:16.760 --> 0:19:20.640
<v Speaker 2>Everyone's dying from it. I need to know more.

0:19:21.200 --> 0:19:24.480
<v Speaker 1>Yeah, Okay, Well here we go. Okay, So what I'm

0:19:24.480 --> 0:19:26.560
<v Speaker 1>going to do is I'm going to talk first a

0:19:26.600 --> 0:19:29.880
<v Speaker 1>little bit about the characteristics of sweating sickness and then

0:19:30.040 --> 0:19:33.800
<v Speaker 1>sort of go through each of the epidemics, and then

0:19:34.280 --> 0:19:36.600
<v Speaker 1>I think, and then I want to hear from you

0:19:36.960 --> 0:19:39.880
<v Speaker 1>about the different diseases that you have, and we'll try

0:19:39.880 --> 0:19:42.800
<v Speaker 1>to like symptom match. Yeah, and then at the same time,

0:19:42.880 --> 0:19:45.040
<v Speaker 1>like I have sort of at the end of my notes,

0:19:45.040 --> 0:19:49.320
<v Speaker 1>like an epidemiological breakdown of things like who had affected,

0:19:49.359 --> 0:19:53.479
<v Speaker 1>where it happened, when it happened, et cetera. Yeah, okay,

0:19:54.359 --> 0:19:57.080
<v Speaker 1>And the rapid thing I mean, like how quickly people died.

0:19:57.920 --> 0:20:01.400
<v Speaker 1>It doesn't seem to be just you know, the exaggeration

0:20:01.680 --> 0:20:05.560
<v Speaker 1>or drama of the fourteen and fifteen hundreds, like one

0:20:05.560 --> 0:20:08.879
<v Speaker 1>of the authors or one of these scholars wrote that quote.

0:20:09.320 --> 0:20:12.679
<v Speaker 1>We saw two priests standing together and speaking together and

0:20:12.720 --> 0:20:16.520
<v Speaker 1>saw both of them die suddenly. Also in the last day,

0:20:16.720 --> 0:20:19.160
<v Speaker 1>we see the wife of a tailor who suddenly died.

0:20:19.560 --> 0:20:22.520
<v Speaker 1>Another young man walking by the street fell down suddenly

0:20:23.160 --> 0:20:27.280
<v Speaker 1>what immediately? Some were killed opening their windows, some in

0:20:27.359 --> 0:20:29.760
<v Speaker 1>playing with children in their street, some in one hour,

0:20:29.920 --> 0:20:33.080
<v Speaker 1>many and two. It destroyed as it found them. So

0:20:33.200 --> 0:20:35.800
<v Speaker 1>it took them, some in sleep, some in wake, some

0:20:35.920 --> 0:20:39.000
<v Speaker 1>in mirth, some in care, some fasting, and some full,

0:20:39.359 --> 0:20:40.919
<v Speaker 1>some busy, and some idol.

0:20:41.480 --> 0:20:46.119
<v Speaker 2>What Aaron, I know, I know, and what you're telling

0:20:46.160 --> 0:20:50.199
<v Speaker 2>me too, is like the number one symptom is the

0:20:50.240 --> 0:20:52.440
<v Speaker 2>fever and sweat fever.

0:20:52.359 --> 0:20:56.760
<v Speaker 1>Sweat, rapid death. There's also seems to be difficulty breathing, so.

0:20:56.880 --> 0:20:59.720
<v Speaker 2>Okay, but how much of that is just because you've

0:20:59.760 --> 0:21:01.760
<v Speaker 2>been sweating so much and your heart rate is so

0:21:01.800 --> 0:21:03.639
<v Speaker 2>high that now you're just like to kipnik because your

0:21:03.640 --> 0:21:05.840
<v Speaker 2>body is like on overdrive, which is what it sounds like.

0:21:05.920 --> 0:21:10.680
<v Speaker 2>More than like that you're a veterinary. Any pulmonary issues, right,

0:21:11.320 --> 0:21:15.080
<v Speaker 2>there's no cough, there's no spuedum, there's no oh my gosh,

0:21:15.160 --> 0:21:15.600
<v Speaker 2>airin it.

0:21:17.680 --> 0:21:19.280
<v Speaker 1>I mean, yeah, there doesn't seem to be a cough.

0:21:19.320 --> 0:21:24.639
<v Speaker 1>There's no rash like I no rash, Yeah, what I know,

0:21:25.359 --> 0:21:30.080
<v Speaker 1>I know, Okay, Okay. The people living in England during

0:21:30.119 --> 0:21:33.359
<v Speaker 1>the time of the Sweat were no stranger to a

0:21:33.440 --> 0:21:37.520
<v Speaker 1>quick and unexpected death, but this was shocking, like even

0:21:37.560 --> 0:21:40.320
<v Speaker 1>to them. Yeah. And another reason that it may have

0:21:40.359 --> 0:21:43.560
<v Speaker 1>stood out was not just how rapidly it seemed to

0:21:43.600 --> 0:21:46.119
<v Speaker 1>descend on a village or town, but also how quickly

0:21:46.160 --> 0:21:49.480
<v Speaker 1>it left. So within let's say, like five days, you

0:21:49.560 --> 0:21:51.760
<v Speaker 1>might see the same number of burials you would normally

0:21:51.760 --> 0:21:54.919
<v Speaker 1>see in several months. It's just this big blip on

0:21:54.960 --> 0:21:59.440
<v Speaker 1>the radar, whereas outbreaks of plague and influenza and smallpox

0:21:59.800 --> 0:22:02.199
<v Speaker 1>and other infectious diseases would show up in more of

0:22:02.280 --> 0:22:06.320
<v Speaker 1>like this rolling wave fashion, slow build sustained intensity and

0:22:06.359 --> 0:22:09.760
<v Speaker 1>then a gradual decline, And sweating sickness was like a

0:22:09.840 --> 0:22:13.080
<v Speaker 1>rogue wave, just like boom right in the middle.

0:22:13.400 --> 0:22:13.640
<v Speaker 2>Right.

0:22:14.359 --> 0:22:20.199
<v Speaker 1>And this character and this characteristic of sweating sickness is

0:22:20.200 --> 0:22:23.920
<v Speaker 1>also super useful for a present day analysis or investigation

0:22:24.000 --> 0:22:28.120
<v Speaker 1>into the disease because it allows researchers to identify likely

0:22:28.160 --> 0:22:34.080
<v Speaker 1>outbreaks of sweating sickness using parish registers which recorded baptisms, marriages,

0:22:34.119 --> 0:22:37.920
<v Speaker 1>and burials among other things. Okay, and so even if

0:22:37.920 --> 0:22:40.679
<v Speaker 1>a parish register didn't note that it was specifically the

0:22:40.720 --> 0:22:43.520
<v Speaker 1>sweat that was responsible for a burst of death, you

0:22:43.560 --> 0:22:47.280
<v Speaker 1>can use information from nearby registers to note likely outbreaks

0:22:47.320 --> 0:22:50.040
<v Speaker 1>and to estimate the impact that an epidemic of sweating

0:22:50.080 --> 0:22:53.720
<v Speaker 1>sickness had on a particular village or a town, and

0:22:53.840 --> 0:22:58.919
<v Speaker 1>to also study geographical variation in outbreaks. So not only

0:22:59.240 --> 0:23:02.760
<v Speaker 1>was the sweating sacness deadly and lightning fast, it also

0:23:02.840 --> 0:23:06.560
<v Speaker 1>appeared to be brand new and unknown outside of England,

0:23:06.760 --> 0:23:09.560
<v Speaker 1>at least at the time of the fourteen eighty five epidemic.

0:23:10.920 --> 0:23:13.480
<v Speaker 1>And so, like we heard in the first hand account,

0:23:13.760 --> 0:23:16.359
<v Speaker 1>a new kind of sickness came through the whole region,

0:23:16.400 --> 0:23:19.480
<v Speaker 1>which was so sore, so painful, and sharp that the

0:23:19.640 --> 0:23:22.520
<v Speaker 1>like was never heard of to any man's remembrance before

0:23:22.560 --> 0:23:23.080
<v Speaker 1>that time.

0:23:26.080 --> 0:23:27.880
<v Speaker 2>I'm really having a hard time with this.

0:23:28.400 --> 0:23:34.080
<v Speaker 1>I know, I love it. And this this newness also

0:23:34.200 --> 0:23:38.360
<v Speaker 1>played into the explanations put forth by scholars who lived

0:23:38.440 --> 0:23:42.199
<v Speaker 1>during that time. So remember, germ theory is hundreds of

0:23:42.280 --> 0:23:46.160
<v Speaker 1>years away at this point, and so superstition or meteorological

0:23:46.240 --> 0:23:49.840
<v Speaker 1>or celestial explanations really took kind of front and center.

0:23:50.200 --> 0:23:53.399
<v Speaker 2>Honestly, I'm not surprised, like I'm leading that way right now.

0:23:53.680 --> 0:23:58.760
<v Speaker 1>I know, I know. Maybe it was punishment for supporting

0:23:58.800 --> 0:24:01.119
<v Speaker 1>Henry the seventh, or maybe it was the way that

0:24:01.160 --> 0:24:04.800
<v Speaker 1>the planets were aligned, or maybe it was just bad air,

0:24:05.160 --> 0:24:09.199
<v Speaker 1>bad air. What did seem clear was that there seemed

0:24:09.200 --> 0:24:11.959
<v Speaker 1>to be no way to predict or control when it

0:24:12.000 --> 0:24:15.560
<v Speaker 1>emerged and when it disappeared, which it only did a

0:24:15.680 --> 0:24:18.480
<v Speaker 1>handful of times, never to be seen again.

0:24:19.359 --> 0:24:22.440
<v Speaker 2>Or was it I don't know, Erin you tell me.

0:24:23.960 --> 0:24:26.520
<v Speaker 1>Okay, So now I'm going to go through these sweating

0:24:26.600 --> 0:24:30.840
<v Speaker 1>sickness epidemics briefly, just finish up the timeline, and then

0:24:31.520 --> 0:24:34.679
<v Speaker 1>I want to hear from you, okay, all right, So

0:24:34.800 --> 0:24:38.320
<v Speaker 1>the fourteen eighty five epidemic of sweating sickness arrived in

0:24:38.400 --> 0:24:40.919
<v Speaker 1>mid to late summer and disappeared within a few months,

0:24:41.560 --> 0:24:44.679
<v Speaker 1>and it wasn't until fifteen oh eight that the sweat

0:24:44.680 --> 0:24:47.439
<v Speaker 1>showed up again. And there isn't a whole lot of

0:24:47.480 --> 0:24:50.760
<v Speaker 1>information about this particular outbreak, maybe because it seemed to

0:24:50.800 --> 0:24:54.040
<v Speaker 1>be less extensive than the previous one. But one important

0:24:54.040 --> 0:24:56.720
<v Speaker 1>thing to note is that it began, like the previous one,

0:24:56.960 --> 0:25:00.000
<v Speaker 1>in summer, so June fifteen oh eight, and burned out

0:25:00.080 --> 0:25:04.200
<v Speaker 1>by October that same year. Okay, And again this epidemic

0:25:04.280 --> 0:25:07.520
<v Speaker 1>seemed to be restricted to England, and I mean just England, like,

0:25:07.600 --> 0:25:09.119
<v Speaker 1>not even Wales or Scotland.

0:25:09.560 --> 0:25:10.520
<v Speaker 2>What okay?

0:25:10.640 --> 0:25:15.119
<v Speaker 1>Yeah, And next we have fifteen seventeen, again beginning near

0:25:15.160 --> 0:25:17.560
<v Speaker 1>the end of June and stopping by the end of October,

0:25:17.960 --> 0:25:20.480
<v Speaker 1>at which point it was overshadowed by an outbreak of

0:25:20.480 --> 0:25:23.440
<v Speaker 1>the plague that was apparently much more devastating, so which

0:25:23.440 --> 0:25:26.000
<v Speaker 1>is why we probably don't know a whole lot about

0:25:26.040 --> 0:25:30.359
<v Speaker 1>that one. And like the previous two epidemics, this one

0:25:30.440 --> 0:25:34.080
<v Speaker 1>was again constrained to England and primarily in London, although

0:25:34.080 --> 0:25:38.280
<v Speaker 1>nearby areas were affected, so like Oxford and Cambridge were

0:25:38.320 --> 0:25:41.719
<v Speaker 1>said to have become ghost towns during this outbreak, and

0:25:41.880 --> 0:25:45.439
<v Speaker 1>four hundred students at Oxford reportedly died within a week.

0:25:45.960 --> 0:25:48.040
<v Speaker 1>What there is a lot.

0:25:48.280 --> 0:25:53.760
<v Speaker 2>Four hundred students, So we're talking young people. Yep, yeah, okay,

0:25:53.880 --> 0:25:55.600
<v Speaker 2>that's an important piece of information.

0:25:55.880 --> 0:25:59.960
<v Speaker 1>It is. And the fourth epidemic, which occurred in fifteen

0:26:00.119 --> 0:26:03.399
<v Speaker 1>twenty eight, broke with the established pattern of epidemics in

0:26:03.400 --> 0:26:06.240
<v Speaker 1>that this one also seemed to cross the English Channel

0:26:06.280 --> 0:26:10.880
<v Speaker 1>to continental Europe the following year, and this outbreak also

0:26:10.920 --> 0:26:13.959
<v Speaker 1>seemed to be particularly devastating, with some reports of up

0:26:13.960 --> 0:26:17.920
<v Speaker 1>to forty thousand people in London becoming infected, although only

0:26:17.960 --> 0:26:22.960
<v Speaker 1>two thousand dying. And this nineteen twenty eight epidemic is

0:26:23.000 --> 0:26:26.120
<v Speaker 1>the one that Henry the eighth fled from with many

0:26:26.119 --> 0:26:29.560
<v Speaker 1>members of his court, although several of them died, some

0:26:29.720 --> 0:26:32.240
<v Speaker 1>only after like an hour or two of symptoms appearing.

0:26:33.040 --> 0:26:37.560
<v Speaker 1>What and just like just to further illustrate how quickly

0:26:37.600 --> 0:26:40.040
<v Speaker 1>this came on and how rapidly devastating it could be.

0:26:40.840 --> 0:26:44.720
<v Speaker 1>At the Archbishop of Canterbury's house, eighteen members of the

0:26:44.760 --> 0:26:48.159
<v Speaker 1>household died of the sweat in just four hours.

0:26:48.560 --> 0:26:53.720
<v Speaker 2>What I'm losing it erin.

0:26:53.960 --> 0:26:54.840
<v Speaker 1>I know, I know.

0:26:55.400 --> 0:27:01.240
<v Speaker 2>It's eight died within four Okay, I mean this doesn't

0:27:01.240 --> 0:27:02.920
<v Speaker 2>even sound like an infectious disease.

0:27:03.560 --> 0:27:06.840
<v Speaker 1>Well, okay, interesting that you should say put a pin

0:27:06.880 --> 0:27:07.440
<v Speaker 1>in that. Okay.

0:27:07.640 --> 0:27:08.360
<v Speaker 2>Yeah.

0:27:08.520 --> 0:27:11.880
<v Speaker 1>Also Anne Bolin became infected but recovered.

0:27:12.200 --> 0:27:15.280
<v Speaker 2>Okay. I feel like, okay, because I remember you saying

0:27:15.359 --> 0:27:17.560
<v Speaker 2>that this was in the Tutors and I was like, oh,

0:27:17.600 --> 0:27:20.160
<v Speaker 2>should I watch that season? But then I didn't because

0:27:20.160 --> 0:27:23.000
<v Speaker 2>I didn't want to learn about it. But also it

0:27:23.040 --> 0:27:24.760
<v Speaker 2>was in the first season, wasn't it.

0:27:24.760 --> 0:27:26.639
<v Speaker 1>It was in the it was Yeah, I watched, like,

0:27:27.080 --> 0:27:29.639
<v Speaker 1>I didn't manage to watch the entire episode. But it's

0:27:29.640 --> 0:27:30.920
<v Speaker 1>season one, episode seven.

0:27:31.000 --> 0:27:32.920
<v Speaker 2>Okay, I definitely have seen it, but it was long

0:27:33.000 --> 0:27:35.240
<v Speaker 2>enough ago that I don't remember anything except like a

0:27:35.320 --> 0:27:38.240
<v Speaker 2>vague running down the halls being sweaty or something.

0:27:38.920 --> 0:27:42.040
<v Speaker 1>Yeah, I don't know. I'm not sure how representative it was.

0:27:42.080 --> 0:27:46.080
<v Speaker 1>I also started reading Wolf Hall, which also apparently portrays

0:27:46.119 --> 0:27:49.240
<v Speaker 1>like sweating sickness epidemics because it takes place during the

0:27:49.280 --> 0:27:51.560
<v Speaker 1>same time, covers the same people, et cetera, et cetera.

0:27:51.600 --> 0:27:53.600
<v Speaker 1>But I also that book is a lot bigger than

0:27:53.640 --> 0:27:57.800
<v Speaker 1>I thought it was, so didn't quite make it all

0:27:57.840 --> 0:28:02.040
<v Speaker 1>the way through anyway. And so again with this fifteen

0:28:02.080 --> 0:28:06.040
<v Speaker 1>twenty eight epidemic. The disease emerged in June and disappeared

0:28:06.200 --> 0:28:11.000
<v Speaker 1>in September. But the following year, fifteen twenty nine, is

0:28:11.040 --> 0:28:14.280
<v Speaker 1>when we see a similar disease appear in continental Europe,

0:28:14.800 --> 0:28:18.360
<v Speaker 1>beginning in July in Germany and Austria and then spreading

0:28:18.359 --> 0:28:23.000
<v Speaker 1>to the Netherlands, Poland, Prussia, Denmark, Sweden, Norway, Finland, Lithuania,

0:28:23.119 --> 0:28:27.440
<v Speaker 1>Russia and elsewhere. So like all over and by September

0:28:27.480 --> 0:28:30.399
<v Speaker 1>it was gone. And there's been some discussion as to

0:28:30.440 --> 0:28:33.439
<v Speaker 1>whether or not this disease on continental Europe was the

0:28:33.480 --> 0:28:36.520
<v Speaker 1>same as the English sweating sickness, but it seems like

0:28:36.720 --> 0:28:40.360
<v Speaker 1>they were because the description of symptoms are similar. And

0:28:40.520 --> 0:28:42.720
<v Speaker 1>maybe the biggest clue is that it was referred to

0:28:42.840 --> 0:28:46.560
<v Speaker 1>as the English sweat or pseudor angelicus or the English

0:28:46.600 --> 0:28:50.080
<v Speaker 1>bath or other names that clearly place its origin in England.

0:28:50.640 --> 0:28:52.920
<v Speaker 2>Did they talk about how bad they lay stunk?

0:28:54.560 --> 0:28:57.680
<v Speaker 1>Yeah, so perfect, Thank you for asking that I have

0:28:57.720 --> 0:29:03.280
<v Speaker 1>a quote. In fifteen twenty nine, a terrible disease spread

0:29:03.320 --> 0:29:07.000
<v Speaker 1>in the Lowlands at Cologne, Antwerp, Frankfurt, reaching as far

0:29:07.040 --> 0:29:10.000
<v Speaker 1>as Strasbourg, so that in these places a great many

0:29:10.000 --> 0:29:12.880
<v Speaker 1>people died. And they called this disease the English sweat

0:29:12.960 --> 0:29:15.880
<v Speaker 1>because it came from England. And whoever was affected by

0:29:15.920 --> 0:29:18.960
<v Speaker 1>this disease went from life to death in twenty four hours.

0:29:19.480 --> 0:29:22.120
<v Speaker 1>For when one was afflicted with the disease, it came

0:29:22.160 --> 0:29:26.160
<v Speaker 1>with a great poisonous sweating, and one sweated to death forthwith,

0:29:26.520 --> 0:29:29.800
<v Speaker 1>so that countless people died of the disease everywhere. Some

0:29:29.840 --> 0:29:32.360
<v Speaker 1>people sat down to table in good health and were

0:29:32.360 --> 0:29:33.240
<v Speaker 1>carried away dead.

0:29:33.680 --> 0:29:34.760
<v Speaker 2>What erin?

0:29:40.280 --> 0:29:43.560
<v Speaker 1>I know? Are you going to devote your the rest

0:29:43.600 --> 0:29:45.280
<v Speaker 1>of your life to study the English sweating section?

0:29:45.400 --> 0:29:48.840
<v Speaker 2>Yeah, that's it, that's my career, okay, For I feel likedicine.

0:29:48.840 --> 0:29:49.600
<v Speaker 1>It's inevitable.

0:29:49.800 --> 0:29:52.000
<v Speaker 2>It's sweating sickness all the time.

0:29:53.720 --> 0:29:56.840
<v Speaker 1>And so after this fifteen twenty eight and fifteen twenty

0:29:56.960 --> 0:29:59.320
<v Speaker 1>nine epidemic, which seems to be the only one that

0:29:59.360 --> 0:30:02.880
<v Speaker 1>spread to content mental Europe, the sweating sickness made only

0:30:03.040 --> 0:30:08.560
<v Speaker 1>one more appearance in fifteen fifty one, again in England.

0:30:08.480 --> 0:30:09.960
<v Speaker 2>And this a long time later.

0:30:10.880 --> 0:30:15.480
<v Speaker 1>Yeah, yeah, we'll talk about the intervals. So keyes describes

0:30:15.560 --> 0:30:18.880
<v Speaker 1>this last epidemic as beginning in April in fifteen fifty

0:30:18.920 --> 0:30:21.320
<v Speaker 1>one and spreading over the country over the next few

0:30:21.360 --> 0:30:26.520
<v Speaker 1>months before dying out in September. London's death toll peaked

0:30:26.560 --> 0:30:28.680
<v Speaker 1>at over seven hundred people in a week in the

0:30:28.720 --> 0:30:32.360
<v Speaker 1>middle of July, and some towns reportedly lost half of

0:30:32.400 --> 0:30:38.520
<v Speaker 1>their population. After fifteen fifty one, sweating sickness seems to

0:30:38.600 --> 0:30:41.560
<v Speaker 1>have just like dropped off the face of the earth.

0:30:41.880 --> 0:30:46.320
<v Speaker 1>Entirely isolated cases of a similar disease may have shown

0:30:46.400 --> 0:30:49.760
<v Speaker 1>up in parts of Germany, France, northern Spain, northern Italy

0:30:49.880 --> 0:30:52.760
<v Speaker 1>and Holland over the next couple hundred years, but no

0:30:52.960 --> 0:30:57.840
<v Speaker 1>large epidemics, and these isolated cases aren't often mentioned in

0:30:58.160 --> 0:31:04.320
<v Speaker 1>histories of sweating sickness. What is commonly mentioned, however, is

0:31:04.640 --> 0:31:08.600
<v Speaker 1>Piccardi sweat I'm hoping I'm saying that right, another infectious

0:31:08.640 --> 0:31:12.600
<v Speaker 1>disease of unknown cause that first emerged in seventeen eighteen

0:31:12.720 --> 0:31:16.600
<v Speaker 1>in northern France and later spread to Germany, Austria, Belgium,

0:31:16.600 --> 0:31:20.719
<v Speaker 1>Switzerland and Italy. And the last extensive outbreak of this

0:31:20.800 --> 0:31:25.600
<v Speaker 1>disease occurred in nineteen oh six in France, and there

0:31:25.640 --> 0:31:28.360
<v Speaker 1>were so there seems to be two forms of the

0:31:28.480 --> 0:31:35.320
<v Speaker 1>Picardy sweat, one very mild resembling Nephropathia epidemica.

0:31:34.280 --> 0:31:39.400
<v Speaker 2>Is that one of the hauntaviruses, uh huh okay, yeah.

0:31:38.640 --> 0:31:42.680
<v Speaker 1>And another more severe version that more closely resembled the

0:31:42.720 --> 0:31:47.239
<v Speaker 1>sweating sickness but was still much more mild. There were

0:31:47.240 --> 0:31:50.960
<v Speaker 1>also some like fairly substantial differences between the two diseases

0:31:50.960 --> 0:31:54.440
<v Speaker 1>in terms of their symptoms. So, for instance, the Piccardi

0:31:54.560 --> 0:31:58.040
<v Speaker 1>sweat was often accompanied by a rash and subsequent peeling

0:31:58.080 --> 0:32:01.680
<v Speaker 1>of the skin, as well as noseblas, neither of which

0:32:01.720 --> 0:32:03.680
<v Speaker 1>seemed to be symptoms of sweating sickness.

0:32:04.040 --> 0:32:06.160
<v Speaker 2>But is it just because everyone died so quickly that

0:32:06.240 --> 0:32:09.240
<v Speaker 2>they didn't show any other symptoms? That's I meaning, I'm wondering.

0:32:09.520 --> 0:32:12.320
<v Speaker 1>Yeah, that's possible. I don't know how quickly the rash

0:32:12.360 --> 0:32:15.680
<v Speaker 1>came on, but definitely the more severe version of the

0:32:15.680 --> 0:32:21.360
<v Speaker 1>Piccardi sweat does seem to be like extremely rapid onset. Okay,

0:32:21.400 --> 0:32:24.440
<v Speaker 1>But the mortality rate of the Piccardi sweat ranged from

0:32:24.480 --> 0:32:27.920
<v Speaker 1>like zero to twenty percent, while the sweating sickness was

0:32:28.120 --> 0:32:32.040
<v Speaker 1>much much more fatal like estimates put it at thirty

0:32:32.080 --> 0:32:38.200
<v Speaker 1>to fifty percent. Okay, So the two diseases probably weren't

0:32:38.200 --> 0:32:42.280
<v Speaker 1>the same, but I think that they were probably or

0:32:42.320 --> 0:32:45.000
<v Speaker 1>a lot of people think that they were probably linked,

0:32:45.600 --> 0:32:49.080
<v Speaker 1>like may may have been caused by the same vector

0:32:49.240 --> 0:32:53.480
<v Speaker 1>or reservoir, or may have similar ecological origins actually, like.

0:32:53.480 --> 0:32:56.080
<v Speaker 2>A similar type of pathogen or something like that. Maybe.

0:32:56.400 --> 0:32:59.320
<v Speaker 1>Yeah, yeah, So.

0:33:00.720 --> 0:33:02.600
<v Speaker 2>I have a lot of ideas.

0:33:02.160 --> 0:33:06.720
<v Speaker 1>Aaron, Yeah, I mean I don't know. So now at

0:33:06.720 --> 0:33:09.840
<v Speaker 1>this point, it's like, is it time to go through?

0:33:10.080 --> 0:33:11.160
<v Speaker 2>Can we love to?

0:33:11.680 --> 0:33:11.920
<v Speaker 1>Okay?

0:33:11.960 --> 0:33:12.720
<v Speaker 2>Reiley would love to?

0:33:13.160 --> 0:33:16.040
<v Speaker 1>So what are the things I even told you to research?

0:33:16.040 --> 0:33:16.960
<v Speaker 1>Because I don't remember.

0:33:18.880 --> 0:33:21.200
<v Speaker 2>There's several. It's actually fun because some of these things

0:33:21.200 --> 0:33:24.600
<v Speaker 2>we've already covered, and some of them were going to cover.

0:33:26.320 --> 0:33:32.160
<v Speaker 2>So you told me to research ergot relapsing fever, hauntavirus

0:33:32.400 --> 0:33:37.000
<v Speaker 2>or a type of hantavirus, and anthrax, and then also

0:33:37.040 --> 0:33:40.280
<v Speaker 2>peripherally influenza. But I feel like we can say it's

0:33:40.320 --> 0:33:41.120
<v Speaker 2>not influenza.

0:33:41.760 --> 0:33:44.400
<v Speaker 1>Yeah, And the reason so I will say that, like

0:33:45.200 --> 0:33:49.440
<v Speaker 1>I told you these before I really started doing extensive research,

0:33:49.640 --> 0:33:53.239
<v Speaker 1>and this was I pulled those those wikipedias is from

0:33:53.280 --> 0:33:56.960
<v Speaker 1>Wikipedia being r liked these are what scholars have put

0:33:57.000 --> 0:33:58.760
<v Speaker 1>forth as possible explanations.

0:33:59.000 --> 0:34:02.600
<v Speaker 2>Yeah, so let's go through them. And I have a

0:34:02.640 --> 0:34:03.840
<v Speaker 2>favorite already.

0:34:04.160 --> 0:34:05.320
<v Speaker 1>Oh what's your favorite?

0:34:05.520 --> 0:34:07.640
<v Speaker 2>Well, we'll go over it last. Okay, let's just take

0:34:07.680 --> 0:34:10.040
<v Speaker 2>a quick break. I feel like we need to breathe.

0:34:10.320 --> 0:34:13.959
<v Speaker 1>Yeah, yeah, yeah, for sure, and sweat.

0:34:14.080 --> 0:34:41.359
<v Speaker 2>And sweat Okay, yeah, I have a favorite already, erin.

0:34:42.840 --> 0:34:45.160
<v Speaker 2>But the thing is it's not perfect. I guess that's

0:34:45.200 --> 0:34:47.680
<v Speaker 2>the point of a medical mystery, is like nothing really

0:34:47.680 --> 0:34:50.880
<v Speaker 2>fits perfectly. Yeah, but based on the ones that you

0:34:51.320 --> 0:34:54.879
<v Speaker 2>told me to look up because Wikipedia said, we can

0:34:55.040 --> 0:34:58.719
<v Speaker 2>very quickly eliminate several of them and we can talk

0:34:58.760 --> 0:35:01.360
<v Speaker 2>about why, and then we can go through the one

0:35:02.280 --> 0:35:05.080
<v Speaker 2>that I think seems like the best option.

0:35:05.680 --> 0:35:07.520
<v Speaker 1>Okay, perfect, Okay.

0:35:07.600 --> 0:35:11.800
<v Speaker 2>So influenza. If you haven't listened to our very first

0:35:11.880 --> 0:35:15.120
<v Speaker 2>episode of this entire podcast, you can learn all about

0:35:15.120 --> 0:35:18.480
<v Speaker 2>influenza on that episode. But basically, this does not sound

0:35:18.560 --> 0:35:20.120
<v Speaker 2>anything like influenza.

0:35:20.200 --> 0:35:22.440
<v Speaker 1>It does not. And so that was one of like

0:35:23.040 --> 0:35:25.880
<v Speaker 1>the that was one of the earliest explanations put forth,

0:35:26.280 --> 0:35:29.320
<v Speaker 1>and I think that it was very popular and retained

0:35:29.360 --> 0:35:33.399
<v Speaker 1>popularity for a while because the nineteen eighteen influenza had

0:35:33.440 --> 0:35:38.040
<v Speaker 1>a similar like pattern in that it attacked who seemed

0:35:38.040 --> 0:35:41.080
<v Speaker 1>to be like the youngest and healthiest with a real predominance.

0:35:41.160 --> 0:35:44.080
<v Speaker 2>Yeah, right, And certainly it's not out of the question

0:35:44.120 --> 0:35:46.560
<v Speaker 2>that you would have a brand new strain of influenza,

0:35:46.880 --> 0:35:50.040
<v Speaker 2>and it could be much more deadly like the nineteen

0:35:50.080 --> 0:35:54.880
<v Speaker 2>eighteen pandemic. But otherwise symptoms wise, like this sudden onset

0:35:54.920 --> 0:35:57.520
<v Speaker 2>of fever and fever being the one and only like

0:35:57.640 --> 0:36:00.480
<v Speaker 2>major symptom that just doesn't really fit with what we

0:36:00.520 --> 0:36:03.360
<v Speaker 2>see with influenza. Even if it's a different strain, like

0:36:03.680 --> 0:36:08.000
<v Speaker 2>influenza is usually a slightly more gradual onset, You're definitely

0:36:08.040 --> 0:36:10.319
<v Speaker 2>going to have some kind of respiratory symptoms a lot

0:36:10.320 --> 0:36:13.440
<v Speaker 2>of times because it is a respiratory pathogen, and usually

0:36:13.440 --> 0:36:17.239
<v Speaker 2>when we see the more severe forms, it's because it's

0:36:17.239 --> 0:36:21.279
<v Speaker 2>causing like a viral pneumonia rather than just you know,

0:36:21.640 --> 0:36:25.439
<v Speaker 2>sweating and then dying. Right, So I think we can

0:36:25.520 --> 0:36:29.960
<v Speaker 2>pretty confidently say it's very unlikely that this was an influenza,

0:36:30.080 --> 0:36:33.440
<v Speaker 2>especially an influenza strain that like remained localized to only

0:36:33.760 --> 0:36:36.720
<v Speaker 2>England and then didn't spread to anywhere.

0:36:36.360 --> 0:36:40.120
<v Speaker 1>Else, Right, what does that tell us about transmission or Yeah,

0:36:40.320 --> 0:36:42.480
<v Speaker 1>probably wasn't respiratory.

0:36:44.600 --> 0:36:47.759
<v Speaker 2>Okay, another one I think we can pretty quickly eliminate

0:36:47.920 --> 0:36:51.480
<v Speaker 2>is actually going to be ergot, Yes, for sure. So

0:36:51.719 --> 0:36:54.560
<v Speaker 2>ergot we talked a lot about in the Dancing Plague episode.

0:36:55.560 --> 0:36:58.480
<v Speaker 2>This whole episode is actually just like see previous episodes.

0:36:58.719 --> 0:37:02.360
<v Speaker 1>I know, I know, I know, but we will.

0:37:02.160 --> 0:37:05.120
<v Speaker 2>Go through it. So Ergot, a fungus, produces a number

0:37:05.160 --> 0:37:09.920
<v Speaker 2>of different alkaloids, including ergotamine, which if you ingest or

0:37:09.960 --> 0:37:12.560
<v Speaker 2>gotamine or any of these other alkaloids, that's when you

0:37:12.600 --> 0:37:15.200
<v Speaker 2>get these type of symptoms. What I like about this

0:37:15.320 --> 0:37:19.920
<v Speaker 2>as an explanation is that ergot is not an infectious disease, right.

0:37:19.960 --> 0:37:22.840
<v Speaker 2>It's like you're ingesting this alkaloid produced by this fungus,

0:37:22.920 --> 0:37:25.799
<v Speaker 2>and so the onset can be really rapid. And from

0:37:25.800 --> 0:37:29.240
<v Speaker 2>what you're saying, the onset of this is so rapid

0:37:29.280 --> 0:37:32.400
<v Speaker 2>that it's it's hard to believe this is an infectious

0:37:32.400 --> 0:37:34.680
<v Speaker 2>disease because it's so very rapid like that.

0:37:35.320 --> 0:37:42.280
<v Speaker 1>Well, yes, and it also affected like members of a household, Okay,

0:37:42.520 --> 0:37:44.000
<v Speaker 1>in clusters.

0:37:43.920 --> 0:37:46.360
<v Speaker 2>Right, so I could see that as well.

0:37:47.040 --> 0:37:50.800
<v Speaker 1>Right, But there are a lot of things against ergot too.

0:37:51.000 --> 0:37:53.640
<v Speaker 2>Yeah, Like, for example, the symptoms are nothing.

0:37:53.400 --> 0:37:56.200
<v Speaker 1>Like correct that would be the number one thing.

0:37:56.600 --> 0:37:59.960
<v Speaker 2>Yeah, So the signs and symptoms of ergot generally how

0:38:00.160 --> 0:38:03.759
<v Speaker 2>to do with Like it causes vasoconstriction, So depending on

0:38:03.800 --> 0:38:06.680
<v Speaker 2>where that vasoconstriction is, you're either going to have like

0:38:06.840 --> 0:38:10.440
<v Speaker 2>tissue death and limbs falling off, or you have like

0:38:10.480 --> 0:38:14.200
<v Speaker 2>a convulsive form where it's affecting your central nervous system,

0:38:14.600 --> 0:38:19.120
<v Speaker 2>so you have like nausea, vomiting, diarrhea, convulsions, all kinds

0:38:19.160 --> 0:38:24.800
<v Speaker 2>of weird sensations, but nothing like this super high fever sweating,

0:38:25.320 --> 0:38:28.240
<v Speaker 2>Like that's just not something that you really see. Certainly

0:38:28.320 --> 0:38:32.960
<v Speaker 2>hallucinations and delirium like you were talking about, but because

0:38:32.960 --> 0:38:35.840
<v Speaker 2>of the ergotomy, not because of the fever and sweat.

0:38:36.320 --> 0:38:41.400
<v Speaker 1>Yeah, I think maybe not ergot, but a food born

0:38:41.880 --> 0:38:45.120
<v Speaker 1>type of thing. Ye was also like, I know botulism

0:38:45.280 --> 0:38:49.279
<v Speaker 1>was briefly proposed at some point, but I don't that

0:38:49.520 --> 0:38:50.319
<v Speaker 1>again doesn't fit.

0:38:50.480 --> 0:38:52.600
<v Speaker 2>It doesn't fit. Yeah, symptoms wise, it doesn't fit. I

0:38:52.640 --> 0:38:57.200
<v Speaker 2>agree that like cluster wise in a household and onset wise,

0:38:57.480 --> 0:39:01.560
<v Speaker 2>some kind of pre formed toxin or a food borne something.

0:39:01.880 --> 0:39:05.399
<v Speaker 2>I could see that fitting with some of the epidemiological characteristics,

0:39:05.440 --> 0:39:09.440
<v Speaker 2>but there aren't a ton of those I mean there

0:39:09.480 --> 0:39:13.279
<v Speaker 2>are some that cause fever, but really actually no, they're

0:39:13.320 --> 0:39:15.200
<v Speaker 2>not a ton that really caused this kind of fever

0:39:15.280 --> 0:39:18.719
<v Speaker 2>that you would see because fever is indicative of inflammation,

0:39:18.880 --> 0:39:23.040
<v Speaker 2>which is something that we see more with you know, infection,

0:39:23.320 --> 0:39:26.719
<v Speaker 2>rather than I don't know right well.

0:39:26.760 --> 0:39:28.799
<v Speaker 1>And I think there's also the matter and I kind

0:39:28.800 --> 0:39:32.520
<v Speaker 1>of I mean, I definitely have withheld some key points.

0:39:32.640 --> 0:39:34.400
<v Speaker 2>Oh great things a lot, Aaron.

0:39:37.200 --> 0:39:38.920
<v Speaker 1>I just think that it would be I think that

0:39:38.960 --> 0:39:42.160
<v Speaker 1>we can back and forth this so like so like

0:39:42.239 --> 0:39:45.920
<v Speaker 1>when we're talking about how sweating sickness seemed to be spread,

0:39:46.760 --> 0:39:49.600
<v Speaker 1>it doesn't really fit food board pathogen. It does seem

0:39:49.640 --> 0:39:53.799
<v Speaker 1>to have traveled along roads, so like if it took

0:39:53.840 --> 0:39:57.919
<v Speaker 1>fifteen days to travel between one village and another, that

0:39:58.080 --> 0:40:02.160
<v Speaker 1>is often the interval that was seen, the interval between

0:40:02.440 --> 0:40:06.279
<v Speaker 1>outbreaks in particular villages or towns, And that bit of

0:40:06.280 --> 0:40:09.200
<v Speaker 1>information I think is really interesting because it points towards

0:40:09.680 --> 0:40:15.160
<v Speaker 1>human to human transmission. But the pattern geographically of epidemics

0:40:16.000 --> 0:40:19.880
<v Speaker 1>is that rural areas seem to be hit hard and

0:40:20.000 --> 0:40:23.560
<v Speaker 1>cities maybe not as hard as you might expect if

0:40:23.560 --> 0:40:27.560
<v Speaker 1>it were something like a crowd disease or a transmitted

0:40:27.600 --> 0:40:30.880
<v Speaker 1>person to person. So what it seems to be is

0:40:30.880 --> 0:40:35.880
<v Speaker 1>that there was another source of infection, but that human

0:40:35.920 --> 0:40:37.880
<v Speaker 1>to human was also possible.

0:40:38.040 --> 0:40:41.400
<v Speaker 2>Okay, okay, So another one that you had me research

0:40:41.480 --> 0:40:43.480
<v Speaker 2>that I don't think that it is, even though I

0:40:43.520 --> 0:40:45.920
<v Speaker 2>do think there are a number of things that I

0:40:46.000 --> 0:40:52.280
<v Speaker 2>understand why this is a common proposition is hauntavirus. Ooh, see,

0:40:52.360 --> 0:40:54.799
<v Speaker 2>your face tells me that you think countavirus is the

0:40:54.840 --> 0:40:55.359
<v Speaker 2>best fit.

0:40:55.960 --> 0:40:56.359
<v Speaker 1>I do.

0:40:56.840 --> 0:40:59.840
<v Speaker 2>Yeah. I mean you're withholding a lot of information, so

0:41:00.080 --> 0:41:03.200
<v Speaker 2>maybe that information is going to tell me that I agree.

0:41:03.239 --> 0:41:06.200
<v Speaker 2>But I actually this is a spoiler, but I think

0:41:06.280 --> 0:41:08.000
<v Speaker 2>relapsing fever fits really well.

0:41:08.480 --> 0:41:11.160
<v Speaker 1>Okay, interesting, and there's a few.

0:41:11.000 --> 0:41:14.520
<v Speaker 2>Reasons why I think that could be the case, even

0:41:14.560 --> 0:41:17.680
<v Speaker 2>though there are some symptoms that don't really fit relapsing fever.

0:41:19.440 --> 0:41:22.200
<v Speaker 2>But okay, so let's go through hantavirus then, or do

0:41:22.239 --> 0:41:23.920
<v Speaker 2>you want to go through anthrax because I don't think

0:41:23.960 --> 0:41:24.680
<v Speaker 2>it's anthrax.

0:41:25.400 --> 0:41:26.880
<v Speaker 1>I don't think it's anthax either.

0:41:27.000 --> 0:41:29.480
<v Speaker 2>Okay, So do we want to talk about why or

0:41:29.520 --> 0:41:33.160
<v Speaker 2>should we just wait until we do anthrax as an episode?

0:41:33.280 --> 0:41:35.480
<v Speaker 1>I think we should talk about why just briefly.

0:41:36.239 --> 0:41:40.839
<v Speaker 2>Okay, So anthrax is a disease caused by a bacterium

0:41:41.200 --> 0:41:45.960
<v Speaker 2>kind of called Bacillus anthrasis. This is a gram positive,

0:41:46.520 --> 0:41:52.160
<v Speaker 2>aerobic spore forming bacterium. So that is important because what

0:41:52.239 --> 0:41:56.040
<v Speaker 2>it means is that when this bacteria senses a change

0:41:56.160 --> 0:41:59.480
<v Speaker 2>in their environment such that it becomes unfavorable, like a

0:41:59.520 --> 0:42:03.880
<v Speaker 2>low neutrient environment, they form this spore which is very

0:42:04.040 --> 0:42:09.040
<v Speaker 2>environmentally hardy, much like Claustridium species do, like we talked

0:42:09.040 --> 0:42:11.640
<v Speaker 2>about in botulism, and so it can survive in the

0:42:11.680 --> 0:42:16.600
<v Speaker 2>soil for years. So anthrax is kind of global in distribution,

0:42:17.040 --> 0:42:20.880
<v Speaker 2>like this bacteria lives and this spore can persist in

0:42:20.920 --> 0:42:26.080
<v Speaker 2>the soil for like decades potentially. But what happens is

0:42:26.480 --> 0:42:29.879
<v Speaker 2>if you get exposed to the spores in a couple

0:42:29.960 --> 0:42:32.799
<v Speaker 2>of different ways, either through your skin like a break

0:42:32.800 --> 0:42:36.480
<v Speaker 2>in your skin, or through your gastrointestinal tract, or the

0:42:36.520 --> 0:42:40.720
<v Speaker 2>worst form is if you inhale the spores. What happens

0:42:40.760 --> 0:42:43.960
<v Speaker 2>is those spores get engulfed by our macrophages, which are

0:42:43.960 --> 0:42:47.200
<v Speaker 2>white blood cells, and then within our white blood cells

0:42:47.200 --> 0:42:49.440
<v Speaker 2>as they travel like to our lymph nodes, they can

0:42:49.560 --> 0:42:54.760
<v Speaker 2>like reactivate into the live bacteria and these bacteria produce

0:42:54.880 --> 0:42:58.600
<v Speaker 2>a number of different exotoxins that cause a lot of problems.

0:42:59.239 --> 0:43:01.719
<v Speaker 2>So I mean, and really none of the symptoms of

0:43:01.840 --> 0:43:07.520
<v Speaker 2>cutaneous like which is skin, or gastrointestinal or inhalational anthrax,

0:43:07.880 --> 0:43:11.600
<v Speaker 2>none of those symptom wise really fit with the description

0:43:11.680 --> 0:43:15.440
<v Speaker 2>of the illness that you gave for sweating sickness. Certainly.

0:43:15.920 --> 0:43:19.239
<v Speaker 2>One thing that does fit is that this is something that,

0:43:19.360 --> 0:43:23.240
<v Speaker 2>like these spores could be transmitted on an animal. For example,

0:43:23.280 --> 0:43:25.480
<v Speaker 2>it's very common for people who work with animals or

0:43:25.520 --> 0:43:31.680
<v Speaker 2>livestock to become infected either with inhalational or gastrointestinal anthrax.

0:43:32.400 --> 0:43:35.440
<v Speaker 2>So kind of the travel and like that kind of distribution.

0:43:35.880 --> 0:43:38.239
<v Speaker 2>Maybe if you had anthrax in one area and then

0:43:38.280 --> 0:43:41.120
<v Speaker 2>it moved, you know, with I don't know, livestock or

0:43:41.120 --> 0:43:44.520
<v Speaker 2>something to another area, maybe you could see that. And also,

0:43:44.640 --> 0:43:50.640
<v Speaker 2>inhalational anthrax is very deadly and very rapid. You start

0:43:50.640 --> 0:43:54.000
<v Speaker 2>with like a pretty non specific fever, feeling cruddy, having

0:43:54.080 --> 0:43:57.520
<v Speaker 2>muscle aches you especially because we're talking about inhalational here,

0:43:57.760 --> 0:43:59.960
<v Speaker 2>you usually have a cough. Right, this is something that's

0:44:00.040 --> 0:44:03.479
<v Speaker 2>causing inflammation in your lungs, so you might have abdominal pain,

0:44:03.520 --> 0:44:07.480
<v Speaker 2>but also chest pain and then over a couple of days,

0:44:07.600 --> 0:44:12.000
<v Speaker 2>you get a further fever, but also more shortness of breath,

0:44:12.120 --> 0:44:14.680
<v Speaker 2>a lot of trouble breathing. This occurs over a couple

0:44:14.680 --> 0:44:19.680
<v Speaker 2>of days, and then like at that point, especially if

0:44:19.680 --> 0:44:24.080
<v Speaker 2>this crosses your blood brain barrier and causes meningitis, then

0:44:24.320 --> 0:44:28.520
<v Speaker 2>very rapidly you progress to shock, hypothermia and death within

0:44:28.840 --> 0:44:31.800
<v Speaker 2>like a number of hours, like twenty four hours or something.

0:44:31.960 --> 0:44:34.719
<v Speaker 2>But that's after a few days of feeling cruddy and

0:44:34.760 --> 0:44:37.839
<v Speaker 2>having a fever and that kind of thing. So that

0:44:37.880 --> 0:44:41.200
<v Speaker 2>doesn't really fit. And then cutaneous and gastrointestinal wise, like

0:44:41.360 --> 0:44:43.080
<v Speaker 2>absolutely doesn't fit well.

0:44:43.120 --> 0:44:47.160
<v Speaker 1>And also the fact that like anthrax was known and

0:44:47.840 --> 0:44:51.640
<v Speaker 1>is still like was around, it didn't disappear, whereas this

0:44:51.760 --> 0:44:55.759
<v Speaker 1>really does seem to be this incredibly unique disease that

0:44:55.880 --> 0:44:56.839
<v Speaker 1>then disappeared.

0:44:58.200 --> 0:45:02.440
<v Speaker 2>That's interesting. That's why I can't there I'm gonna make

0:45:02.440 --> 0:45:04.360
<v Speaker 2>an argument still for relapsing fever.

0:45:04.840 --> 0:45:09.160
<v Speaker 1>No, that's totally fine. I'm curious because this is the

0:45:09.200 --> 0:45:12.760
<v Speaker 1>thing is that like maybe I feel like I'm leaning

0:45:12.800 --> 0:45:15.799
<v Speaker 1>more towards hantavirus A because of the papers I've read,

0:45:15.800 --> 0:45:18.400
<v Speaker 1>but be because I already know more about hauntavirus. I

0:45:18.400 --> 0:45:22.920
<v Speaker 1>don't know really anything about relapsing fever except it's transmission route.

0:45:22.719 --> 0:45:26.839
<v Speaker 2>Right well, And I mean i'd like I dove into

0:45:26.840 --> 0:45:28.719
<v Speaker 2>all of these, but I don't think I dove as

0:45:28.760 --> 0:45:30.400
<v Speaker 2>deeply as I would have if we were doing a

0:45:30.440 --> 0:45:32.800
<v Speaker 2>full length episode on it. So I also feel like

0:45:32.840 --> 0:45:35.400
<v Speaker 2>I don't know everything there is to know about relapsing fever,

0:45:35.480 --> 0:45:37.600
<v Speaker 2>and I definitely feel like I know more about hantavirus.

0:45:37.680 --> 0:45:43.799
<v Speaker 2>But yeah, I mean, okay, let's talk about hantavirus. Yeah,

0:45:43.960 --> 0:45:47.239
<v Speaker 2>So if you want even more deep dive on hantavirus,

0:45:47.480 --> 0:45:49.040
<v Speaker 2>it's all the way back in season two. We did

0:45:49.080 --> 0:45:52.279
<v Speaker 2>a whole episode on it. But there's a whole bunch

0:45:52.280 --> 0:45:58.840
<v Speaker 2>of different hauntaviruses. They all are RNA viruses. They're commonly

0:45:58.840 --> 0:46:02.879
<v Speaker 2>found in rodent and moles and shrews. That was Aaron

0:46:02.920 --> 0:46:05.040
<v Speaker 2>hauntavirus was the episode when I learned that moles and

0:46:05.040 --> 0:46:06.240
<v Speaker 2>shrews are not rodents.

0:46:09.000 --> 0:46:10.920
<v Speaker 1>I think I just relearned that when you said that.

0:46:13.280 --> 0:46:17.920
<v Speaker 2>The most deadly of hantaviruses is the synombree virus, which

0:46:18.040 --> 0:46:22.720
<v Speaker 2>causes hantavirus pulmonary syndrome, which has the highest case fatality

0:46:22.760 --> 0:46:26.160
<v Speaker 2>rate of like forty to fifty percent. But there are

0:46:26.200 --> 0:46:29.200
<v Speaker 2>a number of other hantaviruses that we know of, including

0:46:29.320 --> 0:46:34.879
<v Speaker 2>soul virus, hantan virus, Pumla virus, and Dobrava virus, which

0:46:34.960 --> 0:46:37.960
<v Speaker 2>tend to cause a disease that we call heemorrhagic fever

0:46:38.120 --> 0:46:42.759
<v Speaker 2>with renal syndrome. So if we're talking about like hantavirus

0:46:42.880 --> 0:46:48.600
<v Speaker 2>pulmonary syndrome, you definitely get fever, you definitely get muscle aches,

0:46:49.280 --> 0:46:55.480
<v Speaker 2>headache is certainly one of those symptoms, abdominal pain, diarrhea maybe,

0:46:56.040 --> 0:46:59.640
<v Speaker 2>And importantly, you don't have those upper respiratory symptoms, which

0:46:59.680 --> 0:47:03.080
<v Speaker 2>is in because even though this is a pulmonary illness,

0:47:03.320 --> 0:47:05.479
<v Speaker 2>at the first part of this disease, you don't really

0:47:05.480 --> 0:47:12.120
<v Speaker 2>have any kind of pulmonary like lung symptoms. But this

0:47:12.200 --> 0:47:15.080
<v Speaker 2>is a long like it's a longer disease, like the

0:47:15.120 --> 0:47:18.239
<v Speaker 2>first phase usually lasts three to five days, but even

0:47:18.320 --> 0:47:22.800
<v Speaker 2>up to two weeks. And then after that first phase

0:47:22.800 --> 0:47:26.160
<v Speaker 2>where you're just kind of feeling cruddy, then you start

0:47:26.160 --> 0:47:30.040
<v Speaker 2>to have these heart and lung symptoms, and within twenty

0:47:30.040 --> 0:47:32.080
<v Speaker 2>four to forty eight hours of that is when you

0:47:32.120 --> 0:47:35.760
<v Speaker 2>could die. But even still you have a longer period

0:47:35.800 --> 0:47:39.120
<v Speaker 2>of feeling not good and having a fever and having

0:47:39.200 --> 0:47:43.239
<v Speaker 2>all these other symptoms before you die.

0:47:43.400 --> 0:47:47.319
<v Speaker 1>I don't know, erin okay, I feel like we have

0:47:47.440 --> 0:47:52.840
<v Speaker 1>pretty successfully ruled out a few of them, yes, okay,

0:47:53.080 --> 0:47:56.320
<v Speaker 1>and we are now left with like what we think

0:47:56.560 --> 0:47:58.600
<v Speaker 1>and what has been commonly reported as like the two

0:47:58.680 --> 0:48:03.400
<v Speaker 1>leading you propose explanations. What if you briefly laid out

0:48:03.520 --> 0:48:09.200
<v Speaker 1>just the very basic characteristics of hantavirus, the hantavirus pulmonary

0:48:09.239 --> 0:48:13.799
<v Speaker 1>syndrome and relapsing fever, just like how they're transmitted, you know,

0:48:13.920 --> 0:48:16.920
<v Speaker 1>table form type stuff, and then I'll go through the

0:48:16.960 --> 0:48:20.759
<v Speaker 1>epidemiological characteristics of sweating sickness, and we'll kind of talk

0:48:20.800 --> 0:48:22.759
<v Speaker 1>about each point for each of them.

0:48:23.360 --> 0:48:28.960
<v Speaker 2>Okay, that sounds fun, Okay, Okay, So focusing on hantavirus

0:48:29.000 --> 0:48:33.800
<v Speaker 2>pulmonary syndrome, So hantavirus pulmonary syndrome has a case fatality

0:48:33.880 --> 0:48:37.920
<v Speaker 2>rate about thirty thirty to fifty percent.

0:48:39.239 --> 0:48:40.040
<v Speaker 1>Sounds familiar.

0:48:40.080 --> 0:48:44.640
<v Speaker 2>It does sound familiar. Relapsing fever, first of all, importantly,

0:48:44.680 --> 0:48:48.080
<v Speaker 2>there are two different forms of relapsing fever. There's lousborn

0:48:48.160 --> 0:48:51.439
<v Speaker 2>relapsing fever, and there's tickborn relapsing fever and They're very

0:48:51.440 --> 0:48:55.520
<v Speaker 2>different in terms of their epidemiological characteristics, and I think

0:48:55.680 --> 0:48:59.400
<v Speaker 2>this sounds much more like loosborn relapsing fever, which is

0:48:59.680 --> 0:49:02.640
<v Speaker 2>more common in groups. It's more common in epidemics and

0:49:03.080 --> 0:49:07.320
<v Speaker 2>has a case fatality rate of between ten to forty percent.

0:49:07.960 --> 0:49:09.960
<v Speaker 1>Okay, okay, okay.

0:49:10.000 --> 0:49:19.000
<v Speaker 2>So hantavirus transmission. Hantavirus is transmitted by aerosolized mouse poop. Essentially,

0:49:19.440 --> 0:49:23.120
<v Speaker 2>it's transmitted by aerosols, but not person to person.

0:49:23.760 --> 0:49:27.239
<v Speaker 1>However, there is an asterisk next to that not transmitted

0:49:27.280 --> 0:49:31.960
<v Speaker 1>person to person because there have been instances reported in

0:49:32.200 --> 0:49:35.960
<v Speaker 1>Argentina that suggest person to person transmission since there.

0:49:35.840 --> 0:49:39.680
<v Speaker 2>Is some possibility of at least one specific strain, but

0:49:39.920 --> 0:49:42.439
<v Speaker 2>most hauntaviruses have not ever been shown to be able

0:49:42.440 --> 0:49:47.800
<v Speaker 2>to be transmitted person to person. Now, what about relapsing fever.

0:49:48.280 --> 0:49:52.000
<v Speaker 2>This is fun. First of all, relapsing fever is caused

0:49:52.040 --> 0:49:57.120
<v Speaker 2>by Brellia species, so these are spirokeet bacteria not too

0:49:57.320 --> 0:50:00.839
<v Speaker 2>distantly related to lyme disease, but different species. And there's

0:50:00.880 --> 0:50:05.880
<v Speaker 2>a number of different species of Burrellia that can cause

0:50:05.920 --> 0:50:11.520
<v Speaker 2>relapsing fever, which I think is important. And while tickborn

0:50:12.360 --> 0:50:16.080
<v Speaker 2>relapsing fever is transmitted from the bite of a tick,

0:50:16.400 --> 0:50:20.480
<v Speaker 2>much like many other tickborn diseases. Louse born relapsing fever

0:50:21.000 --> 0:50:24.840
<v Speaker 2>is transmitted from the hemolymph, which is the blood of

0:50:25.320 --> 0:50:29.120
<v Speaker 2>a louse. That means that if a louse is living

0:50:29.160 --> 0:50:32.360
<v Speaker 2>on you and you know, biting you, and so you're itchy,

0:50:32.400 --> 0:50:36.840
<v Speaker 2>and then you scratch you like smoosh that louse and

0:50:36.880 --> 0:50:39.720
<v Speaker 2>then you scrape it open and you scrape their blood

0:50:39.760 --> 0:50:44.799
<v Speaker 2>into your skin, that's how you become infected. And I'm

0:50:44.840 --> 0:50:49.480
<v Speaker 2>pretty sure that there have been some suggestion that there

0:50:49.600 --> 0:50:53.399
<v Speaker 2>might be for LuSE born relapsing fever, that there could

0:50:53.480 --> 0:50:56.800
<v Speaker 2>be person to person transmission based on eptymilogical characterism.

0:50:57.040 --> 0:50:59.359
<v Speaker 1>Okay, cool, interesting, I.

0:50:59.280 --> 0:51:05.000
<v Speaker 2>Got so excited that I couldn't finish that word. Some

0:51:05.040 --> 0:51:09.680
<v Speaker 2>other characteristics. So incubation period I think is probably important because,

0:51:09.680 --> 0:51:11.759
<v Speaker 2>like you said, if this was moving kind of like

0:51:11.960 --> 0:51:14.319
<v Speaker 2>village to village or area to area in about the

0:51:14.320 --> 0:51:17.680
<v Speaker 2>time it takes for someone to travel, then you're probably

0:51:17.719 --> 0:51:20.560
<v Speaker 2>not looking at something that has a super long incubation period.

0:51:21.640 --> 0:51:26.200
<v Speaker 2>So for hantavirus, it's actually quite a long incubation period.

0:51:26.280 --> 0:51:29.359
<v Speaker 2>It's usually like two to three weeks incubation period after

0:51:29.400 --> 0:51:33.760
<v Speaker 2>exposure to symptoms relapsing fever, there's a pretty big range.

0:51:33.960 --> 0:51:36.879
<v Speaker 2>In general, it's about seven days, but it can be

0:51:37.000 --> 0:51:40.240
<v Speaker 2>as low as four or as high as like eighteen, okay.

0:51:41.160 --> 0:51:43.640
<v Speaker 2>And then duration of illness. And this is the part

0:51:43.640 --> 0:51:48.440
<v Speaker 2>where honestly none of these fit really well, because with hantavirus,

0:51:48.520 --> 0:51:53.799
<v Speaker 2>especially hantavirus pulmonary syndrome, you have a first phase of

0:51:54.360 --> 0:52:00.200
<v Speaker 2>kind of fever, malaise, not feeling great, headache, and that

0:52:00.360 --> 0:52:04.400
<v Speaker 2>usually lasts three to five days, but even up to

0:52:04.480 --> 0:52:07.600
<v Speaker 2>like twelve days where you're just feeling bad. And then

0:52:07.760 --> 0:52:10.799
<v Speaker 2>when you get to the second phase where you have

0:52:10.960 --> 0:52:14.920
<v Speaker 2>shock and pulmonary edema, so like fluid in your lungs,

0:52:15.560 --> 0:52:19.680
<v Speaker 2>that usually happens really quickly, within like twenty forty eight hours,

0:52:20.840 --> 0:52:23.280
<v Speaker 2>and then you might die. But in general you're feeling

0:52:23.320 --> 0:52:27.880
<v Speaker 2>creddy for at least three to five days before that. Yeah, Okay,

0:52:28.200 --> 0:52:32.160
<v Speaker 2>Now with relapsing fever, I mean you said this, sometimes

0:52:32.200 --> 0:52:40.160
<v Speaker 2>people relapse saren So relapsing fever does start very abruptly

0:52:40.480 --> 0:52:43.440
<v Speaker 2>with a very abrupt onset of a really really high

0:52:43.520 --> 0:52:50.600
<v Speaker 2>fever along with shaking, chills, headache, and delirium. Interesting, and

0:52:50.640 --> 0:52:54.280
<v Speaker 2>you often also have very severe joint pain, muscle aches,

0:52:54.520 --> 0:52:57.680
<v Speaker 2>nausea and vomiting, and extreme weakness, like you can't even

0:52:57.680 --> 0:53:00.400
<v Speaker 2>get up and walk because you're so weak and feel

0:53:00.480 --> 0:53:03.719
<v Speaker 2>extremely lethargic. Okay, like you said, all you want to

0:53:03.719 --> 0:53:07.160
<v Speaker 2>do is sleep. Yeah, and then you can also get

0:53:07.200 --> 0:53:10.560
<v Speaker 2>like a very profound anorexia, feeling so bad like you

0:53:10.680 --> 0:53:13.360
<v Speaker 2>just don't want to eat. You might have weight loss.

0:53:16.120 --> 0:53:20.480
<v Speaker 2>But and this is where it just falls apart, Aaron.

0:53:22.160 --> 0:53:27.200
<v Speaker 2>The first fever, this really high onset fever. Your skin

0:53:27.400 --> 0:53:34.840
<v Speaker 2>is usually hot and dry. It's like a very classic description,

0:53:35.000 --> 0:53:37.960
<v Speaker 2>It's a hot and dry Which the reason that this

0:53:38.160 --> 0:53:40.600
<v Speaker 2>is like outlined in all of these clinical descriptions is

0:53:40.600 --> 0:53:43.680
<v Speaker 2>because a lot of other diseases that cause a fever,

0:53:43.840 --> 0:53:47.840
<v Speaker 2>especially a relapsing fever like malaria, you usually are sweating

0:53:47.920 --> 0:53:51.200
<v Speaker 2>quite a lot in association with the fever, right, But

0:53:51.520 --> 0:53:54.880
<v Speaker 2>with this one, your skin is described as hot and dry.

0:53:55.920 --> 0:53:58.879
<v Speaker 1>Yeah, that does not sound.

0:53:58.680 --> 0:54:05.160
<v Speaker 2>Like sweating, but it also doesn't I mean, hanta doesn't

0:54:05.160 --> 0:54:06.160
<v Speaker 2>sound like that either.

0:54:06.880 --> 0:54:10.359
<v Speaker 1>So I have a question about relapsing fevers. Okay, how

0:54:10.400 --> 0:54:13.680
<v Speaker 1>diverse is this group or, like, you know, how many

0:54:13.680 --> 0:54:17.719
<v Speaker 1>different bacterial species cause relapsing fever, and how much variety

0:54:17.760 --> 0:54:20.719
<v Speaker 1>in symptoms is there among those species.

0:54:21.200 --> 0:54:24.799
<v Speaker 2>Very good question. So there's I saw, and I didn't

0:54:24.800 --> 0:54:28.439
<v Speaker 2>write down every single species, but loos born relapsing fever

0:54:28.719 --> 0:54:32.360
<v Speaker 2>is mostly one species, and that's Burrellia recurrensis. Okay, but

0:54:32.400 --> 0:54:34.440
<v Speaker 2>there are at least like three or four other species

0:54:34.480 --> 0:54:37.919
<v Speaker 2>of Burrellia that cause tickborn relapsing fever. Yeah, and there's

0:54:38.080 --> 0:54:40.759
<v Speaker 2>a number of different tick species that also can transmit

0:54:41.360 --> 0:54:43.440
<v Speaker 2>so hard ticks and soft.

0:54:43.160 --> 0:54:45.480
<v Speaker 1>Ticks, okay, which is fun. It is fun.

0:54:45.920 --> 0:54:49.400
<v Speaker 2>Yeah, I know we never talk about soft ticks, but

0:54:49.640 --> 0:54:53.080
<v Speaker 2>they do. So tickborn and louis born relapsing fever look

0:54:53.120 --> 0:54:56.680
<v Speaker 2>a little bit different. So like the length of illness

0:54:56.800 --> 0:55:00.000
<v Speaker 2>is different, the mortality rate is different. Tickborn relapsing fever

0:55:00.239 --> 0:55:06.200
<v Speaker 2>is not as deadly as lousborn relapsing fever. Loosbourne usually

0:55:07.000 --> 0:55:09.759
<v Speaker 2>lasts a little bit longer, like five and a half

0:55:09.880 --> 0:55:13.320
<v Speaker 2>days of symptoms rather than three days. And then the

0:55:13.360 --> 0:55:18.120
<v Speaker 2>interval between relapses is also longer for loosborn relapsing fever,

0:55:18.600 --> 0:55:22.080
<v Speaker 2>and you generally have fewer relapses. You have like maybe

0:55:22.120 --> 0:55:26.759
<v Speaker 2>one maybe two relapse. But with tickborn relapsing fever. You

0:55:26.840 --> 0:55:31.840
<v Speaker 2>often have like three or more relapses of symptoms. Okay, Okay,

0:55:32.560 --> 0:55:36.560
<v Speaker 2>now you do often have a rash. It's not uncommon.

0:55:37.200 --> 0:55:40.040
<v Speaker 2>But and this is why I mentioned that in the

0:55:40.080 --> 0:55:44.200
<v Speaker 2>French epidemic where people did have a rash, the rash

0:55:44.239 --> 0:55:46.239
<v Speaker 2>can look a lot of different ways, Like there's a

0:55:46.280 --> 0:55:50.200
<v Speaker 2>lot of different kind of presentations of a rash, but

0:55:50.239 --> 0:55:54.680
<v Speaker 2>it usually happens after the first set of symptoms while

0:55:54.719 --> 0:56:01.040
<v Speaker 2>you're otherwise asymptomatic. So if people survived long enough to

0:56:01.320 --> 0:56:03.720
<v Speaker 2>get to that point, maybe they would have had a rash.

0:56:04.200 --> 0:56:06.839
<v Speaker 1>Okay, okay, but.

0:56:07.320 --> 0:56:09.600
<v Speaker 2>This is getting off of the epic characteristics a little bit.

0:56:09.600 --> 0:56:11.399
<v Speaker 2>But I want to get into the path of physiology

0:56:11.400 --> 0:56:13.680
<v Speaker 2>of how relapsing fever works because this is part of

0:56:13.680 --> 0:56:16.399
<v Speaker 2>what makes me think that maybe it was like a

0:56:16.400 --> 0:56:21.840
<v Speaker 2>certain subtype of Burrellia that caused these particular epidemics. Because

0:56:22.320 --> 0:56:24.720
<v Speaker 2>what I think is really interesting is like what causes

0:56:24.760 --> 0:56:28.680
<v Speaker 2>this relapsing disease? Right, The reason that you have a

0:56:28.760 --> 0:56:33.680
<v Speaker 2>relapsing fever and symptoms in tickborn or lousborn relapsing fever

0:56:33.880 --> 0:56:39.319
<v Speaker 2>is that the bacteria that caused this ary their surface antigens,

0:56:40.160 --> 0:56:43.040
<v Speaker 2>so they change out those proteins that are on their

0:56:43.080 --> 0:56:45.880
<v Speaker 2>surface that our body is responding to in order to

0:56:46.000 --> 0:56:49.640
<v Speaker 2>kill them, and they do so during cycles of disease.

0:56:50.120 --> 0:56:53.719
<v Speaker 2>They change them so well that so you get infected. Right,

0:56:53.800 --> 0:56:57.160
<v Speaker 2>the bacteria enter your bloodstream, either by use scratching them

0:56:57.160 --> 0:57:00.280
<v Speaker 2>in or by a tick spitting them into your bloodstream.

0:57:00.960 --> 0:57:04.040
<v Speaker 2>They replicate. Our body reacts, which is why you have

0:57:04.080 --> 0:57:08.680
<v Speaker 2>all these symptoms, fever, feeling crappy, and then our immune

0:57:08.680 --> 0:57:12.280
<v Speaker 2>system tries to kill them off, but the bacteria go, Okay,

0:57:12.320 --> 0:57:16.360
<v Speaker 2>well you figured out this antigen so we'll just change

0:57:16.480 --> 0:57:19.120
<v Speaker 2>our outer proteins and then our bodies like, oh we

0:57:19.200 --> 0:57:22.440
<v Speaker 2>did it. These bacteria are gone and they don't recognize

0:57:22.480 --> 0:57:24.720
<v Speaker 2>these anymore, so then they can start to replicate all

0:57:24.720 --> 0:57:27.640
<v Speaker 2>over again. You have a huge amount of bacteria in

0:57:27.640 --> 0:57:30.120
<v Speaker 2>your blood again, and it's like a whole new infection.

0:57:30.640 --> 0:57:36.600
<v Speaker 1>That is unbelievably cool. I am very that is fascinating.

0:57:36.840 --> 0:57:38.400
<v Speaker 2>It's so fascinating.

0:57:38.440 --> 0:57:38.760
<v Speaker 1>Wow.

0:57:39.120 --> 0:57:43.000
<v Speaker 2>And so I wonder could it be that there was,

0:57:43.640 --> 0:57:48.240
<v Speaker 2>you know, a particular antigenic subtype that was present in

0:57:48.320 --> 0:57:52.240
<v Speaker 2>England at this time that happened to cause a slightly

0:57:52.280 --> 0:57:57.080
<v Speaker 2>different presentation of this disease. I don't know. I just

0:57:57.120 --> 0:58:00.800
<v Speaker 2>don't know here, I know, I know, I know, Okay.

0:58:00.880 --> 0:58:03.840
<v Speaker 1>So I have a few more questions about like the

0:58:03.840 --> 0:58:08.920
<v Speaker 1>epicharacteristics of relapsing fever and hantavirus or hantavirus pulmonary syndrome. So,

0:58:09.760 --> 0:58:14.400
<v Speaker 1>first of all, is there any general pattern in who,

0:58:14.520 --> 0:58:17.920
<v Speaker 1>like whether it's age group or whatever that is most

0:58:17.960 --> 0:58:21.080
<v Speaker 1>susceptible or seems to have the most outcomes with either

0:58:21.120 --> 0:58:21.439
<v Speaker 1>of these.

0:58:21.800 --> 0:58:26.400
<v Speaker 2>I don't think so, at least nothing that stands out

0:58:26.440 --> 0:58:29.520
<v Speaker 2>in the research that I did. It's not like young

0:58:29.560 --> 0:58:33.080
<v Speaker 2>people only die from this or old people only die from.

0:58:32.880 --> 0:58:37.040
<v Speaker 1>This, Okay. And then what about like any seasonal or

0:58:37.120 --> 0:58:38.760
<v Speaker 1>temporal aspect.

0:58:39.200 --> 0:58:43.280
<v Speaker 2>So with tickborn relapsing fever, it certainly is something that's

0:58:43.320 --> 0:58:45.840
<v Speaker 2>going to be more common when people are outside and

0:58:45.880 --> 0:58:49.120
<v Speaker 2>when ticks are outside, which is going to be in

0:58:49.160 --> 0:58:52.600
<v Speaker 2>the summer months, laoisborne, it tends to be a more

0:58:52.720 --> 0:58:56.760
<v Speaker 2>epidemic disease. It doesn't tend to be sporadic the way

0:58:56.800 --> 0:59:03.280
<v Speaker 2>that tickborn relapsing fever does. But these are human body lice,

0:59:03.360 --> 0:59:06.200
<v Speaker 2>and so there doesn't tend to be like a specific

0:59:06.280 --> 0:59:09.280
<v Speaker 2>seasonal variation necessarily because human body lice live on us

0:59:09.320 --> 0:59:13.520
<v Speaker 2>all of the time. With hantavirus, I think I remember

0:59:13.560 --> 0:59:15.800
<v Speaker 2>it being something where it's just depends on when you're

0:59:15.840 --> 0:59:17.080
<v Speaker 2>in contact with mice.

0:59:18.360 --> 0:59:21.280
<v Speaker 1>Well, for hantavirus pulmonary syndrome, it was summer summer.

0:59:21.600 --> 0:59:23.840
<v Speaker 2>That makes sense because that's when you're in contact with mice.

0:59:24.320 --> 0:59:30.440
<v Speaker 1>Right, Okay, one final question okay, immunity. Do you gain

0:59:30.480 --> 0:59:31.840
<v Speaker 1>immunity after infection?

0:59:32.440 --> 0:59:33.360
<v Speaker 2>Oh?

0:59:33.400 --> 0:59:36.120
<v Speaker 1>And are there asymptomatic infections?

0:59:36.960 --> 0:59:41.440
<v Speaker 2>Really good question erin I'm going to guess with relapsing fever, no,

0:59:41.720 --> 0:59:45.640
<v Speaker 2>you don't gain immunity because already they're changing up their

0:59:45.680 --> 0:59:48.200
<v Speaker 2>intigens so much that that's why you're having relapses to

0:59:48.200 --> 0:59:52.360
<v Speaker 2>begin with. For hantavirus, there is a vaccine that's available,

0:59:52.400 --> 0:59:54.880
<v Speaker 2>at least in some parts of the world, so I

0:59:54.880 --> 0:59:56.960
<v Speaker 2>would think that there's immunity for at least some portion

0:59:57.000 --> 0:59:59.240
<v Speaker 2>of time. Not sure how long that immunity would last.

1:00:00.000 --> 1:00:03.200
<v Speaker 1>Ok Okay. So I feel like now that we know

1:00:03.840 --> 1:00:09.560
<v Speaker 1>a bit more about the two leading you know, potential causes,

1:00:09.720 --> 1:00:15.680
<v Speaker 1>let's go over the EPI characteristics of sweating sickness. Okay, okay,

1:00:15.800 --> 1:00:43.680
<v Speaker 1>let's take a quick break first. All right, So I've

1:00:43.760 --> 1:00:49.120
<v Speaker 1>grouped the epi characteristics into five basic sections. Okay, so

1:00:49.840 --> 1:00:53.960
<v Speaker 1>you know what was sweating sickness, so like symptoms, case fatality, right,

1:00:53.960 --> 1:00:58.720
<v Speaker 1>et cetera. Number two, how it seemed to spread, number

1:00:58.720 --> 1:01:01.920
<v Speaker 1>three where it occurred, Number four who had affect it,

1:01:01.960 --> 1:01:06.480
<v Speaker 1>and number five when it happened. Okay, Okay, So starting

1:01:06.520 --> 1:01:11.440
<v Speaker 1>with what it was, it was rapid onset fatal disease

1:01:11.600 --> 1:01:16.000
<v Speaker 1>characterized by excessive foul smelling, sweating, fever, body aches and pain,

1:01:16.080 --> 1:01:20.040
<v Speaker 1>stomach pains, headache and delirium, heart palpitations, and breathing that

1:01:20.160 --> 1:01:24.600
<v Speaker 1>was shallow and labored. Death often occurred within the first

1:01:24.640 --> 1:01:28.240
<v Speaker 1>few hours of the first symptoms showing up, and case

1:01:28.280 --> 1:01:33.000
<v Speaker 1>fatality rates very among epidemics and affected regions. So like,

1:01:33.080 --> 1:01:36.040
<v Speaker 1>sometimes it was seemed to be very low, sometimes it

1:01:36.120 --> 1:01:39.960
<v Speaker 1>was really high, but overall it does seem that it

1:01:40.040 --> 1:01:44.000
<v Speaker 1>was a very high mortality rate, and most estimates put

1:01:44.000 --> 1:01:45.360
<v Speaker 1>it at like thirty to fifty percent.

1:01:45.760 --> 1:01:46.080
<v Speaker 2>Okay.

1:01:46.840 --> 1:01:51.080
<v Speaker 1>The only epidemic where mortality could actually be somewhat reliably

1:01:51.080 --> 1:01:55.360
<v Speaker 1>calculated was the fifteen fifty one one. And because that's

1:01:55.560 --> 1:01:59.600
<v Speaker 1>because like, by that point but not for the previous epidemics,

1:01:59.680 --> 1:02:03.320
<v Speaker 1>pair registers actually began to be in use, and so

1:02:04.280 --> 1:02:08.400
<v Speaker 1>we get an estimate from some guy's amazing analysis of

1:02:08.480 --> 1:02:13.920
<v Speaker 1>parish registers that around fifteen thousand deaths were due to

1:02:14.120 --> 1:02:19.720
<v Speaker 1>sweating sickness from in the fifteen fifty one epidemic in England. Okay,

1:02:20.120 --> 1:02:23.840
<v Speaker 1>but let's compare that to thirty thousand deaths from the

1:02:23.880 --> 1:02:27.919
<v Speaker 1>plague in fifteen sixty three in a plague epidemic year,

1:02:28.880 --> 1:02:32.800
<v Speaker 1>and one hundred and eighty thousand deaths from influenza epidemics

1:02:32.880 --> 1:02:36.520
<v Speaker 1>in fifteen fifty seven, fifteen fifty eight, and fifteen fifty nine.

1:02:37.080 --> 1:02:41.880
<v Speaker 1>So although it was deadly, it wasn't nearly didn't cause

1:02:41.920 --> 1:02:44.360
<v Speaker 1>nearly the same loss of life as some of these

1:02:44.400 --> 1:02:51.200
<v Speaker 1>other diseases. Yeah, okay, all right. Number two, how it spread?

1:02:51.800 --> 1:02:54.200
<v Speaker 1>And we talked a little bit about this, but this

1:02:54.400 --> 1:03:00.280
<v Speaker 1>is very challenging to nail down. So basically, it does

1:03:00.360 --> 1:03:05.600
<v Speaker 1>seem that human to human transmission was possible, but that

1:03:05.600 --> 1:03:10.560
<v Speaker 1>that may not be the only route through which a

1:03:10.600 --> 1:03:11.800
<v Speaker 1>pathogen was transmitted.

1:03:12.200 --> 1:03:18.360
<v Speaker 2>See this is why I lean Lausborn because like lice,

1:03:18.720 --> 1:03:23.160
<v Speaker 2>move from person to person and thereby move the disease. Right,

1:03:23.320 --> 1:03:26.800
<v Speaker 2>So it's not directly person to person, but it is

1:03:26.880 --> 1:03:30.320
<v Speaker 2>person to person in that sense. Right, It's not, it's

1:03:30.360 --> 1:03:33.200
<v Speaker 2>not it doesn't need an animal reservoir. It's it's a

1:03:33.280 --> 1:03:34.120
<v Speaker 2>human disease.

1:03:34.760 --> 1:03:38.080
<v Speaker 1>It doesn't, right. But I think what makes me lean

1:03:38.400 --> 1:03:41.959
<v Speaker 1>away from Laos are a number of things, Like one

1:03:42.400 --> 1:03:46.000
<v Speaker 1>is the seasonality, which was very pronounced, like it was

1:03:46.840 --> 1:03:51.480
<v Speaker 1>summer months and then it emerged suddenly, disappeared suddenly, So

1:03:51.640 --> 1:03:56.120
<v Speaker 1>that to me implies some sort of like ecological characteristic

1:03:56.160 --> 1:04:00.600
<v Speaker 1>of this disease. And the second thing is and I

1:04:00.600 --> 1:04:02.880
<v Speaker 1>didn't really go that into it yet, and I will

1:04:02.960 --> 1:04:05.439
<v Speaker 1>right now. I'll skip ahead to number four is who

1:04:05.960 --> 1:04:09.920
<v Speaker 1>it affected? So who sweating sickness mostly affected? And so

1:04:10.160 --> 1:04:12.640
<v Speaker 1>you know, like I said, it seemed to primarily impact

1:04:12.760 --> 1:04:17.560
<v Speaker 1>England only even respecting political boundaries. And I don't really

1:04:17.600 --> 1:04:20.440
<v Speaker 1>know what to make of that, Like maybe contemporary writers

1:04:20.480 --> 1:04:22.720
<v Speaker 1>were just being a bit dramatic and wanting to play

1:04:22.760 --> 1:04:26.320
<v Speaker 1>up the role of England as a victim, or maybe

1:04:26.360 --> 1:04:29.400
<v Speaker 1>it was real, in which case I wonder if there

1:04:29.440 --> 1:04:32.320
<v Speaker 1>was some sort of like cultural or behavioral difference that

1:04:32.400 --> 1:04:36.000
<v Speaker 1>prevented it spread. So like maybe one type of grain

1:04:36.200 --> 1:04:39.800
<v Speaker 1>was more commonly grown and stored in England, thus providing

1:04:39.840 --> 1:04:41.720
<v Speaker 1>more food for rodents, or maybe it was stored in

1:04:41.760 --> 1:04:44.400
<v Speaker 1>a particular way or a certain place that would have

1:04:44.520 --> 1:04:47.880
<v Speaker 1>changed how rodents and humans or arthropod vectors and humans

1:04:47.920 --> 1:04:52.280
<v Speaker 1>interacted with one another. And while some of the names

1:04:52.280 --> 1:04:54.880
<v Speaker 1>for the disease highlight how sweating sickness seemed to be

1:04:54.960 --> 1:04:58.440
<v Speaker 1>an English thing, so like pseudor angelicus the English sweat,

1:04:58.960 --> 1:05:02.240
<v Speaker 1>others seemed to raw attention to the type or class

1:05:02.280 --> 1:05:06.360
<v Speaker 1>of person that was commonly affected, So stoop gallant, stoop

1:05:06.440 --> 1:05:10.720
<v Speaker 1>nave and no thay master, which is like, basically it

1:05:10.840 --> 1:05:17.640
<v Speaker 1>seemed to affect wealthy, well to do healthy young men,

1:05:17.840 --> 1:05:21.840
<v Speaker 1>primarily so between the ages of like fifteen and forty.

1:05:21.760 --> 1:05:24.120
<v Speaker 2>And that would lean kind of away from a lousporn

1:05:24.240 --> 1:05:27.760
<v Speaker 2>just because lice usually it's in more crowded conditions, more

1:05:27.800 --> 1:05:30.560
<v Speaker 2>lower cysio economic status, when you don't have access to

1:05:31.200 --> 1:05:33.240
<v Speaker 2>able to clean yourself and get rid of lice.

1:05:33.280 --> 1:05:35.040
<v Speaker 1>Right, And I talked a bit about the urban to

1:05:35.160 --> 1:05:37.680
<v Speaker 1>rural difference as well, where it did seem to be

1:05:37.720 --> 1:05:41.400
<v Speaker 1>predomint like would hit hard rural areas, but it also

1:05:41.680 --> 1:05:44.880
<v Speaker 1>was in urban areas as well, I don't know, but

1:05:44.960 --> 1:05:48.040
<v Speaker 1>not to the same degree as it was maybe in

1:05:48.480 --> 1:05:54.360
<v Speaker 1>rural areas, okay, And so then the final thing is

1:05:54.800 --> 1:05:57.560
<v Speaker 1>when it happened. And by this I mean two things.

1:05:57.560 --> 1:06:00.760
<v Speaker 1>So one is this very sporadic nature of the epidemics.

1:06:00.760 --> 1:06:04.360
<v Speaker 1>So these like the years separating them are twenty three,

1:06:04.760 --> 1:06:07.960
<v Speaker 1>nine eleven, and again twenty three.

1:06:08.040 --> 1:06:09.120
<v Speaker 2>So that's weird.

1:06:09.520 --> 1:06:13.800
<v Speaker 1>It's very strange, you could say. So some people suggest

1:06:13.800 --> 1:06:16.680
<v Speaker 1>that it's an eleven year a ten year gap, and

1:06:16.720 --> 1:06:19.080
<v Speaker 1>that there are just two missing epidemics. Whether they're missing

1:06:19.120 --> 1:06:22.280
<v Speaker 1>to our knowledge or missing to like whether they actually

1:06:22.280 --> 1:06:25.880
<v Speaker 1>happened or not, it's not known. But there's also this

1:06:26.000 --> 1:06:32.480
<v Speaker 1>very strong seasonal pattern to infection. And if we're going

1:06:32.520 --> 1:06:37.600
<v Speaker 1>along with the hauntavirus thing, some current or modern scholars

1:06:37.600 --> 1:06:41.040
<v Speaker 1>suggest that there were wet years that preceded these epidemics,

1:06:41.040 --> 1:06:44.040
<v Speaker 1>were very wet summers, which is what happened in the

1:06:44.160 --> 1:06:49.000
<v Speaker 1>nineteen ninety three four Corners in Nombree outbreak that led

1:06:49.000 --> 1:06:53.640
<v Speaker 1>to like a much higher mouse population, right exactly. But

1:06:53.840 --> 1:06:56.600
<v Speaker 1>I think that like, I don't know, I mean, if

1:06:56.600 --> 1:07:00.120
<v Speaker 1>we're talking about louseborn relapsing fever and we're talking about

1:07:00.160 --> 1:07:05.640
<v Speaker 1>hauntavirus pulmonary syndrome, those are two very different roots of transmission. Yeah,

1:07:05.680 --> 1:07:08.600
<v Speaker 1>and so I think that's one, and also exposure patterns.

1:07:08.600 --> 1:07:12.880
<v Speaker 1>So like in putting together these pieces, you have the

1:07:12.920 --> 1:07:16.000
<v Speaker 1>strong seasonality, which puts it more in the column of

1:07:16.240 --> 1:07:19.520
<v Speaker 1>hantavirus pulmonary syndrome, which is when like you would have

1:07:20.160 --> 1:07:23.360
<v Speaker 1>very distinct times of year during which you would be

1:07:23.880 --> 1:07:25.600
<v Speaker 1>in contact with rodents.

1:07:25.200 --> 1:07:27.320
<v Speaker 2>And certain years where you're certainly going to have a

1:07:27.400 --> 1:07:30.480
<v Speaker 2>higher risk of transmission because of ecological factors.

1:07:30.520 --> 1:07:37.160
<v Speaker 1>Definitely, right, exactly, And you also have this urban to

1:07:37.280 --> 1:07:42.280
<v Speaker 1>rural variation and infection that does not seem to be

1:07:42.480 --> 1:07:47.720
<v Speaker 1>mediated by like other roots of transmission. I guess. Yeah,

1:07:47.760 --> 1:07:49.439
<v Speaker 1>the symptoms are a whole nother thing.

1:07:49.920 --> 1:07:53.160
<v Speaker 2>Yeah, and that's where for me it falls apart. Like

1:07:53.280 --> 1:07:58.000
<v Speaker 2>for me, the symptoms really do not sound like.

1:07:59.520 --> 1:08:05.480
<v Speaker 1>HPS like the I mean, well, but here's here's something

1:08:05.520 --> 1:08:09.880
<v Speaker 1>that I mean, obviously I have a little like you know,

1:08:10.000 --> 1:08:13.560
<v Speaker 1>pet pet theory. Yeah, it's not my theory at all.

1:08:13.640 --> 1:08:18.200
<v Speaker 1>I found it in papers. But before the nineteen ninety

1:08:18.240 --> 1:08:22.559
<v Speaker 1>three four Corners outbreak of se nombervirus, we didn't have like,

1:08:22.600 --> 1:08:26.280
<v Speaker 1>we didn't know about hantavirus pulmonary syndrome. We didn't know

1:08:26.720 --> 1:08:30.080
<v Speaker 1>that that's how it could manifest in your body, and

1:08:30.120 --> 1:08:33.479
<v Speaker 1>then you know, they do in the descriptions of sweating sickness,

1:08:33.479 --> 1:08:37.000
<v Speaker 1>they talk about how, oh, you were well at luncheon

1:08:37.120 --> 1:08:39.320
<v Speaker 1>or you sat down to dinner and then you were

1:08:39.320 --> 1:08:40.439
<v Speaker 1>carried off, like.

1:08:40.800 --> 1:08:44.439
<v Speaker 2>Right, And I do wonder like, because you also have

1:08:44.520 --> 1:08:46.840
<v Speaker 2>to take into account that this was like the late

1:08:46.960 --> 1:08:50.840
<v Speaker 2>fourteen and early fifteen hundreds, their definition of someone who's

1:08:50.920 --> 1:08:52.800
<v Speaker 2>well might not be the same as our definition of

1:08:52.840 --> 1:08:55.760
<v Speaker 2>someone who's well, so they might actually be kind of miserable,

1:08:55.840 --> 1:09:00.280
<v Speaker 2>but like that's normal for them, right right, So then yeah,

1:09:00.360 --> 1:09:02.679
<v Speaker 2>so then maybe it does seem as though you were

1:09:02.760 --> 1:09:05.320
<v Speaker 2>fine and now you're dead when really like they've been

1:09:05.320 --> 1:09:09.519
<v Speaker 2>feeling cruddy for a couple of days, but they you know,

1:09:09.600 --> 1:09:12.320
<v Speaker 2>they just thought that they didn't get enough sleep, or

1:09:12.400 --> 1:09:16.360
<v Speaker 2>they're always kind of feeling cruddy, whatever it is. So

1:09:17.040 --> 1:09:20.920
<v Speaker 2>in that case, you do have very rapid death once

1:09:21.000 --> 1:09:26.160
<v Speaker 2>you hit that particular phase of hantavirus pulmonary syndrome, and

1:09:26.360 --> 1:09:30.600
<v Speaker 2>even with you know, the other hauntaviruses that are a

1:09:30.600 --> 1:09:35.519
<v Speaker 2>lot less deadly that now circulate in Europe and other

1:09:35.560 --> 1:09:39.040
<v Speaker 2>parts of the world, when you do die from those,

1:09:39.240 --> 1:09:42.200
<v Speaker 2>you die pretty rapidly, right, it's either like you recover

1:09:42.280 --> 1:09:44.200
<v Speaker 2>over a very long period of time or you die

1:09:44.240 --> 1:09:49.439
<v Speaker 2>pretty dang quick. So so yeah, I guess that does

1:09:49.840 --> 1:09:50.960
<v Speaker 2>there are things that fit.

1:09:51.040 --> 1:09:51.680
<v Speaker 3>It's just.

1:09:53.400 --> 1:09:56.760
<v Speaker 1>I don't know. I mean, I think, like I said

1:09:56.760 --> 1:09:58.519
<v Speaker 1>at the beginning of this, this is like an episode

1:09:58.520 --> 1:10:01.360
<v Speaker 1>of Unsolved Mysteries. I hope you go into it.

1:10:01.680 --> 1:10:06.240
<v Speaker 2>And it's just it's also so bizarre that that it

1:10:06.360 --> 1:10:11.960
<v Speaker 2>would be only in England, even if it was a hauntavirus,

1:10:12.040 --> 1:10:18.040
<v Speaker 2>because whatever mice populations or whatever that would be high

1:10:18.040 --> 1:10:20.040
<v Speaker 2>in England, like, why wouldn't they also be high in

1:10:20.040 --> 1:10:22.519
<v Speaker 2>Scotland and Wales. I don't think that the ecology is

1:10:22.560 --> 1:10:24.599
<v Speaker 2>I don't know ecology all that well, but I would

1:10:24.640 --> 1:10:28.519
<v Speaker 2>assume that there are a lot of similar rodent species.

1:10:28.080 --> 1:10:31.639
<v Speaker 1>Right in those areas. Yeah, definitely, and I think there

1:10:31.640 --> 1:10:34.760
<v Speaker 1>were people have looked in the in like writings of

1:10:34.840 --> 1:10:38.439
<v Speaker 1>the time and found no evidence or nothing to suggest

1:10:38.520 --> 1:10:43.000
<v Speaker 1>that there were massive either population booms or massive die

1:10:43.000 --> 1:10:47.960
<v Speaker 1>offs of rodents, like anything unusual about rodent populations. But

1:10:48.320 --> 1:10:52.400
<v Speaker 1>that's where I was wondering whether grain was stored in

1:10:52.439 --> 1:10:54.680
<v Speaker 1>a different way or in a different location in the

1:10:54.800 --> 1:10:58.960
<v Speaker 1>house in England. I mean there's also like there could

1:10:58.960 --> 1:11:01.439
<v Speaker 1>be a wet summer in certain parts of England and

1:11:01.479 --> 1:11:06.719
<v Speaker 1>it could have missed Wales or Scotland entirely. And also

1:11:06.800 --> 1:11:10.080
<v Speaker 1>how much of that is just a little bit of like,

1:11:10.880 --> 1:11:14.840
<v Speaker 1>oh the English are being punished for our support of

1:11:14.880 --> 1:11:19.519
<v Speaker 1>Henry the seventh or something. Yeah, So going over like

1:11:19.800 --> 1:11:22.400
<v Speaker 1>what what do we know? What can we say about this?

1:11:23.200 --> 1:11:28.520
<v Speaker 1>Do we think it was an infectious, contagious transmissible pathogen?

1:11:29.400 --> 1:11:29.879
<v Speaker 2>Maybe?

1:11:30.720 --> 1:11:34.000
<v Speaker 1>I think yes, based on the how it seemed to

1:11:34.040 --> 1:11:38.599
<v Speaker 1>travel along roads or along like common roots, So.

1:11:38.560 --> 1:11:41.000
<v Speaker 2>It seems more like an infectious and like there's some

1:11:41.040 --> 1:11:42.479
<v Speaker 2>component of person to person.

1:11:42.800 --> 1:11:44.680
<v Speaker 1>There's some component of person a person, but it's not

1:11:44.800 --> 1:11:51.200
<v Speaker 1>driven by that. And there's a strong ecological component. Yeah,

1:11:51.240 --> 1:11:57.720
<v Speaker 1>so that points towards either arthropod or rodent, the two

1:11:57.720 --> 1:12:02.800
<v Speaker 1>most likely I mean engineerian In all likelihood, this is

1:12:02.800 --> 1:12:06.600
<v Speaker 1>something that we don't have anymore like why did it disappear?

1:12:06.960 --> 1:12:08.480
<v Speaker 1>No idea which.

1:12:08.240 --> 1:12:11.760
<v Speaker 2>Is even more fascinating, like if this was a virus,

1:12:11.960 --> 1:12:14.479
<v Speaker 2>whether a haunted virus or some other virus or a

1:12:14.520 --> 1:12:22.720
<v Speaker 2>bacteria that caused these specific outbreaks across an entire country.

1:12:23.439 --> 1:12:28.360
<v Speaker 1>And then disappeared, Yeah, where did it go well, unless

1:12:28.400 --> 1:12:32.439
<v Speaker 1>it unless it didn't unless it really was the piccardy sweat,

1:12:33.280 --> 1:12:37.240
<v Speaker 1>which but what's that they don't know, right.

1:12:37.560 --> 1:12:39.799
<v Speaker 2>So then where did it go? It caused one.

1:12:39.680 --> 1:12:44.080
<v Speaker 1>Outbreak nosed, it caused outbreaks starting from seventeen eighteen all

1:12:44.080 --> 1:12:46.400
<v Speaker 1>the way through nineteen o six was the last outbreak.

1:12:46.439 --> 1:12:49.120
<v Speaker 1>The last diagnosed case was in nineteen eighteen.

1:12:49.840 --> 1:12:51.440
<v Speaker 2>That's even weirder arian.

1:12:51.920 --> 1:12:54.599
<v Speaker 1>Is What is the case though, is that most people

1:12:55.040 --> 1:12:59.559
<v Speaker 1>seem to believe that piccardy sweat and sweating sickness were

1:13:00.120 --> 1:13:04.479
<v Speaker 1>different diseases. It didn't like sweating sickness didn't turn into

1:13:04.560 --> 1:13:07.920
<v Speaker 1>piccardi sweat, but that they were probably caused by the

1:13:07.960 --> 1:13:14.920
<v Speaker 1>same thing, whether that was like a rodent, a rodent reservoir,

1:13:15.240 --> 1:13:19.679
<v Speaker 1>some sort of arthropod transmitted virus, or like relapsing fever

1:13:20.320 --> 1:13:21.799
<v Speaker 1>where there is no rodent reservoir.

1:13:22.479 --> 1:13:28.120
<v Speaker 2>Fascinating. Yeah, and there's still like there's still no consensus.

1:13:28.200 --> 1:13:28.920
<v Speaker 2>Is that correct?

1:13:29.320 --> 1:13:32.720
<v Speaker 1>There's still no consensus if you look at the at

1:13:32.720 --> 1:13:36.960
<v Speaker 1>the evolution of thought as to what caused sweating sickness.

1:13:37.040 --> 1:13:42.439
<v Speaker 1>It started out started out influenza and relapsing fever, and

1:13:42.479 --> 1:13:46.080
<v Speaker 1>then it kind of morphed into some sort of arbovirus

1:13:46.080 --> 1:13:49.400
<v Speaker 1>so virus transmitted by an arthropod, But that was kind

1:13:49.439 --> 1:13:51.920
<v Speaker 1>of discarded even by the authors themselves because they were like,

1:13:51.960 --> 1:13:55.280
<v Speaker 1>we don't see any bites or rashes like that would

1:13:55.280 --> 1:13:57.880
<v Speaker 1>have been noted. They feel like it would have been noted.

1:14:00.080 --> 1:14:05.959
<v Speaker 1>And then following the nineteen ninety three four Corners Sonombrite outbreak,

1:14:06.680 --> 1:14:11.240
<v Speaker 1>that is when hantavirus, pulmonary syndrome became the leading cause.

1:14:12.120 --> 1:14:17.680
<v Speaker 2>Interesting, Yeah, even though there's still no pulmonary symptoms.

1:14:18.080 --> 1:14:20.599
<v Speaker 1>I mean they I guess that what they view as

1:14:20.640 --> 1:14:24.719
<v Speaker 1>pulmonary symptoms are the like shallow breathing, difficulty shallow breathing,

1:14:25.280 --> 1:14:26.920
<v Speaker 1>and the heaviness on the chest.

1:14:27.720 --> 1:14:28.320
<v Speaker 2>Interesting.

1:14:28.720 --> 1:14:31.640
<v Speaker 1>Yeah, But you know, I think that it's interesting to

1:14:31.680 --> 1:14:36.280
<v Speaker 1>think about why do we care about this still? Like

1:14:36.320 --> 1:14:37.760
<v Speaker 1>why are we still talking about it?

1:14:38.240 --> 1:14:40.720
<v Speaker 2>Well? I feel like do we have to explain the

1:14:40.760 --> 1:14:43.120
<v Speaker 2>answer to that question when we're living through a pandemic

1:14:43.200 --> 1:14:44.240
<v Speaker 2>of a brand new virus?

1:14:44.680 --> 1:14:48.360
<v Speaker 1>I yeah, exactly exactly, But I think like it is,

1:14:48.760 --> 1:14:53.919
<v Speaker 1>this is such a bizarre and terrifying and fascinating illness,

1:14:54.120 --> 1:14:58.040
<v Speaker 1>sweating sickness in these diseases that we think could be

1:14:58.080 --> 1:15:02.080
<v Speaker 1>related to it, that exists today, like they're still around.

1:15:02.800 --> 1:15:04.840
<v Speaker 1>Does that mean that there's the potential for something like

1:15:04.880 --> 1:15:05.679
<v Speaker 1>this to happen again?

1:15:06.680 --> 1:15:06.720
<v Speaker 2>No?

1:15:07.000 --> 1:15:10.519
<v Speaker 1>Really, I mean yeah, I think I think it all

1:15:10.520 --> 1:15:14.639
<v Speaker 1>boils down to the fact that like understanding the nature

1:15:14.680 --> 1:15:18.400
<v Speaker 1>and the cause of epidemics, whether they're present or especially

1:15:18.479 --> 1:15:21.000
<v Speaker 1>those in the past, can help us just prevent future

1:15:21.040 --> 1:15:21.920
<v Speaker 1>ones from happening.

1:15:22.040 --> 1:15:26.000
<v Speaker 2>So right, and trying to understand too, like, like I

1:15:26.000 --> 1:15:29.800
<v Speaker 2>think we went through like the ecological characteristics of this

1:15:29.920 --> 1:15:33.800
<v Speaker 2>disease as well as the you know, temporal characteristics and

1:15:33.840 --> 1:15:37.400
<v Speaker 2>the epimialological Like understanding all these different facets can really

1:15:37.479 --> 1:15:40.280
<v Speaker 2>help you to narrow in on what you think might

1:15:40.280 --> 1:15:40.920
<v Speaker 2>be the cause.

1:15:41.880 --> 1:15:45.040
<v Speaker 1>You can't just compare symptoms, right, you have to consider

1:15:45.080 --> 1:15:45.720
<v Speaker 1>the context.

1:15:46.080 --> 1:15:46.920
<v Speaker 2>Yeah.

1:15:46.960 --> 1:15:51.160
<v Speaker 1>So yeah, I mean, I don't know, sweating sickness. It

1:15:51.560 --> 1:15:59.600
<v Speaker 1>was a deadly, mysterious, probably infectious, contagious disease with an

1:15:59.640 --> 1:16:02.320
<v Speaker 1>equal component fascinating.

1:16:02.439 --> 1:16:05.759
<v Speaker 2>Aron. I learned so much. I mean I also learned nothing,

1:16:05.800 --> 1:16:06.880
<v Speaker 2>but I learned so much.

1:16:08.400 --> 1:16:13.360
<v Speaker 1>I know, I know it's interesting if anyone has any

1:16:13.360 --> 1:16:18.120
<v Speaker 1>other thoughts on what it could have been or wants

1:16:18.120 --> 1:16:20.440
<v Speaker 1>to vote for their favorite.

1:16:20.680 --> 1:16:23.519
<v Speaker 2>Yeah, I mean I really really felt like I wanted

1:16:23.520 --> 1:16:26.920
<v Speaker 2>for it to be relapsing fever, but I agree ecologically

1:16:26.920 --> 1:16:30.760
<v Speaker 2>it just doesn't quite fit. And even symptoms wise, it

1:16:30.800 --> 1:16:33.920
<v Speaker 2>doesn't quite fit. You know, none of these symptoms wise

1:16:33.960 --> 1:16:37.960
<v Speaker 2>really quite fit perfectly. M hmm, because obviously if they did,

1:16:38.000 --> 1:16:42.600
<v Speaker 2>then we'd have an answer. But some kind of haunted virus,

1:16:43.000 --> 1:16:47.799
<v Speaker 2>I mean, I could see it. I understand that argument. Yeah,

1:16:48.400 --> 1:16:50.960
<v Speaker 2>we may never know, we may never know, but I

1:16:50.960 --> 1:16:51.840
<v Speaker 2>think I could live with that.

1:16:52.600 --> 1:16:56.559
<v Speaker 1>Yeah. Yeah, Okay, Well there you have it. Everyone, There

1:16:56.560 --> 1:17:01.559
<v Speaker 1>you go. We could both be okay with it being

1:17:02.080 --> 1:17:04.200
<v Speaker 1>hauntavirus some kind.

1:17:04.880 --> 1:17:07.760
<v Speaker 2>Well, all right, then I bet you have a ton

1:17:07.800 --> 1:17:08.360
<v Speaker 2>of sources.

1:17:08.960 --> 1:17:16.280
<v Speaker 1>Do a lot of sources, Okay, So I'll call out

1:17:16.920 --> 1:17:20.280
<v Speaker 1>a few of them. One by Eric Bridson from two

1:17:20.280 --> 1:17:21.920
<v Speaker 1>thousand and one, and that was the first one to

1:17:21.960 --> 1:17:27.719
<v Speaker 1>propose hauntavirus pulmonary syndrome as the cause of the English sweat.

1:17:28.960 --> 1:17:31.479
<v Speaker 1>Then there was another incredible paper from nineteen ninety seven

1:17:31.760 --> 1:17:35.400
<v Speaker 1>by Alan Dyer called the English Sweating Sickness of fifteen

1:17:35.479 --> 1:17:39.720
<v Speaker 1>fifty one and Epidemic Anatomized. And then there were some

1:17:39.840 --> 1:17:43.280
<v Speaker 1>other pretty good ones. So I read one by Flood

1:17:43.280 --> 1:17:45.640
<v Speaker 1>from two thousand and three, safer on the battlefield than

1:17:45.640 --> 1:17:49.439
<v Speaker 1>in the city and by taverner at all from nineteen

1:17:49.520 --> 1:17:54.120
<v Speaker 1>ninety eight the English sweating sickness a viral pulmonary disease.

1:17:55.280 --> 1:17:58.680
<v Speaker 2>Awesome. If you'd like to do a deeper dive on

1:17:58.760 --> 1:18:01.600
<v Speaker 2>any of the illnesses that we talked about on this podcast,

1:18:01.680 --> 1:18:05.360
<v Speaker 2>I will have sources from previous episodes as well as

1:18:05.479 --> 1:18:08.360
<v Speaker 2>a few more for diseases that we haven't touched on yet.

1:18:08.800 --> 1:18:11.040
<v Speaker 2>And you can find the sources from every single one

1:18:11.040 --> 1:18:13.240
<v Speaker 2>of our episodes on this podcast will kill You dot

1:18:13.240 --> 1:18:14.840
<v Speaker 2>com under the episodes tab.

1:18:15.520 --> 1:18:19.920
<v Speaker 1>That's right. Well, thank you to Bloodmobile for providing the

1:18:20.000 --> 1:18:22.640
<v Speaker 1>music for this episode and all of our episodes.

1:18:23.400 --> 1:18:26.120
<v Speaker 2>Thank you to the Exactly Right Network, of which we

1:18:26.160 --> 1:18:27.559
<v Speaker 2>are proud to be a part.

1:18:28.000 --> 1:18:31.799
<v Speaker 1>Yes, thank you, and thank you to you listeners for listening.

1:18:32.160 --> 1:18:36.639
<v Speaker 1>We hope that you don't hate this unsatisfying episode.

1:18:37.160 --> 1:18:39.599
<v Speaker 2>I hope that you had fun. I had fun.

1:18:39.920 --> 1:18:41.840
<v Speaker 1>Yeah, I had a lot of fun. And if you

1:18:41.880 --> 1:18:44.080
<v Speaker 1>have any ideas as to what it could be.

1:18:44.560 --> 1:18:46.799
<v Speaker 2>Yeah, let us know. Or if you have other medical

1:18:46.800 --> 1:18:49.120
<v Speaker 2>mysteries you'd like for us to not be able to solve.

1:18:49.400 --> 1:18:56.880
<v Speaker 1>Ooh yes, okay, Well until next time, Wash your hands.

1:18:56.920 --> 1:19:02.760
<v Speaker 2>You filthy animals.

1:19:02.800 --> 1:19:17.880
<v Speaker 3>Ob bonba bonbu ombo oh