WEBVTT - Ep 17 Oh No Tetrodo: Crossover w/ TBOSP

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<v Speaker 1>Hi, I'm erin Welsh and I'm Aaron Alman Updike And this.

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<v Speaker 2>Is this Podcast Will Kill You crossover edition with the

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<v Speaker 2>Biology of Superheroes podcast.

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<v Speaker 1>This is actually part two of a crossover in which

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<v Speaker 1>we're going to talk about zombie. In the first episode,

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<v Speaker 1>which was released on Halloween, we joined Shane Campbell Stayton

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<v Speaker 1>and Arian Darby of the Biology of Superheroes podcast to

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<v Speaker 1>talk all things zombies.

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<v Speaker 2>You guys should definitely go check out that episode. You

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<v Speaker 2>can find it at the Biology of Superheroes podcast on

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<v Speaker 2>whatever platform you listen to your podcasts.

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<v Speaker 1>And this week we're so excited to be joined by

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<v Speaker 1>Shane to take a deeper dive into the physiology, history,

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<v Speaker 1>and evolutionary biology of zombies.

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<v Speaker 2>Do you want to introduce yourself, Shane, Yeah, it's.

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<v Speaker 3>Good to be here. I'm Shane Campbell Stateon and I

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<v Speaker 3>am an evolutionary biologist.

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<v Speaker 1>Hey, yes, doctor Campbell Stateon.

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<v Speaker 3>Please please remember it.

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<v Speaker 1>Also the host of your own amazing podcast tell us

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<v Speaker 1>about It.

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<v Speaker 3>Yeah, we do our thing, so, host of the Biology

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<v Speaker 3>of Superheroes podcast. Yeah. So we use a lot of

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<v Speaker 3>you know, science fiction, and use science fiction basically as

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<v Speaker 3>a way to you know, to talk about biology, evolution, physiology,

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<v Speaker 3>so on and so forth. So merging the nerd multiverse

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<v Speaker 3>over here.

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<v Speaker 2>I love it, Yes, and definitely everyone check it out.

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<v Speaker 2>It's an amazing podcast.

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<v Speaker 1>Yeah, it's fantastic. It's really fun. We've been waiting to

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<v Speaker 1>do this crossover since before we even started our podcast.

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<v Speaker 1>Oh yeah, it's been like on the books.

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<v Speaker 3>It has been a long time coming, isn't it.

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<v Speaker 1>Yeah.

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<v Speaker 2>Okay, so before we jump into that, we've got some

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<v Speaker 2>important business to take care of. Yeah, we do our quarantining.

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<v Speaker 2>What are we drinking this week?

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<v Speaker 1>This week we're drinking Rum for your Life.

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<v Speaker 2>And it's called that because guess what it has in it?

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<v Speaker 2>Rum and more rum.

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<v Speaker 1>It has so much more rum.

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<v Speaker 2>So we will post the entire recipe on all of

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<v Speaker 2>our social media as well as our place Barrita for

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<v Speaker 2>this episode.

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<v Speaker 1>Absolutely you can find us at tpwk Y on Twitter

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<v Speaker 1>and this podcast will kill you on Instagram and Facebook.

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<v Speaker 1>Let's let's get we'll move on.

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<v Speaker 4>Okay, all right, all.

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<v Speaker 2>Right, So today we are talking about zombies and basically

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<v Speaker 2>sort of the biological basis for whether zombification can happen

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<v Speaker 2>via tatrota toxin. And then Shane is going to hit

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<v Speaker 2>us with some expertise on the evolutionary history of tatroda toxin.

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<v Speaker 2>And I don't know anything about it yet, so I'm

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<v Speaker 2>really excited because I think it's super cool. Same, I

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<v Speaker 2>know it's going to be super cool.

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<v Speaker 1>I should say, well.

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<v Speaker 3>We'll see how cool it is when I'm done.

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<v Speaker 1>The coolest. Everyone's going to want to become a marine

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<v Speaker 1>biologist after this episode.

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<v Speaker 2>Yeah, I'm going to take you through the cultural history

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<v Speaker 2>of the zombie, tracing the origins of the modern zombie

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<v Speaker 2>back to it's religious and spiritual roots. And we're going

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<v Speaker 2>to have a blast because, as we talked about, this

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<v Speaker 2>is one of our favorite topics all of us. Yeah,

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<v Speaker 2>and first I want to ask you something. Have you,

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<v Speaker 2>either of you secretly ever wanted to be in a

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<v Speaker 2>zombie apocalypse to maybe see how you'd react or whether

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<v Speaker 2>you'd be the first to die.

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<v Speaker 3>I feel like this is a conversation that I used

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<v Speaker 3>to have, like back in college. You know, It's like

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<v Speaker 3>one of those like two am conversations. Yeah, man, do

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<v Speaker 3>you think you would be able to survive the zombie apocalypse? Yeah? Man, Yeah,

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<v Speaker 3>I totally get a machete and this and that, and

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<v Speaker 3>I go up into the mountains and so on. So

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<v Speaker 3>you know, meanwhile, you know, at that time, I had

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<v Speaker 3>like barely like slept outside, you know, but it's like

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<v Speaker 3>super confident that I'd be able to survive the zombie apocalypse.

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<v Speaker 1>Yeah.

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<v Speaker 2>Yeah, I feel like it's it's human nature to sort

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<v Speaker 2>of think about the end of days scenarios. And yeah,

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<v Speaker 2>I think it's safe to say that we've all watched

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<v Speaker 2>or read our fair share of zombie movies, shows, books, comics,

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<v Speaker 2>et cetera. Because we're nerds nerds, But I don't think

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<v Speaker 2>zombies are necessarily nerdy, are.

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<v Speaker 1>They, Shane, you're the expert.

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<v Speaker 3>Yeah, yeah, I'm gonna put them up as nerdy. They're

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<v Speaker 3>pretty nerd cool.

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<v Speaker 2>Well, I like being a nerd anyway.

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<v Speaker 3>Yeah, ain't nothing wrong with that. I mean to own

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<v Speaker 3>the nerds.

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<v Speaker 1>Yeah exactly.

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<v Speaker 2>So, now that we are self proclaimed zombie experts, I

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<v Speaker 2>want to ask you guys what you see as them

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<v Speaker 2>as the unifying characteristics of zombies or zombies as they

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<v Speaker 2>are presented today, great questions to do a little list.

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<v Speaker 1>I feel like they have to be they have to

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<v Speaker 1>be after humans, so they've got to be like aggressive

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<v Speaker 1>in some way after Okay, not like human no, no, no,

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<v Speaker 1>coming after you for some reason.

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<v Speaker 2>Okay, So driven by human flesh, yes, okay, right, Yeah, I.

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<v Speaker 3>Mean I think there's a typical sort of mangled appearance

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<v Speaker 3>one way or the other, right, either you know, if

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<v Speaker 3>you're talking about the actual walking dead or if you're

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<v Speaker 3>talking about the infected yea, you know there are you know,

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<v Speaker 3>there's typically a you know, very like run down, like

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<v Speaker 3>dirty clothes, bloody thing happening once you turn into a zombie. Yeah,

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<v Speaker 3>you you start to you know, you don't worry about

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<v Speaker 3>taking a shower and washing your clothes anymore. Here preoccupied

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<v Speaker 3>by brains in general, biting related activities.

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<v Speaker 1>Yeah, And I do think the whole transmitted by bite thing,

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<v Speaker 1>it's like it's become pretty classic, right, I'm not opposed

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<v Speaker 1>to it, I'll say that much. I'm not opposed to

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<v Speaker 1>that idea.

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<v Speaker 2>I mean, I haven't I can't think of a modern

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<v Speaker 2>zombie movie that doesn't have where a bite from a

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<v Speaker 2>zombie turns you into a zombi or yeah, agreed, Yeah,

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<v Speaker 2>so okay, so we have that they're mangled dead, undead,

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<v Speaker 2>they eat human flesh. That's that's the sole thing that

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<v Speaker 2>they're driven by. Yeah, and they're infectious or being a

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<v Speaker 2>zombie is infectious for sure. So this the zombie that

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<v Speaker 2>we just that we just described, is this modern zombie

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<v Speaker 2>which was born in nineteen sixty eight when Night of

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<v Speaker 2>the Living Dead was released, which is kind of funny actually,

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<v Speaker 2>considering that the word zombie is never used in the movie.

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<v Speaker 1>Yeah, but that's so typical, and I feel like all

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<v Speaker 1>zombie movies now do that because they did that, and

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<v Speaker 1>it really bothers me. Like in Walking Dead, why can't

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<v Speaker 1>they just call them zombie? What do they call them

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<v Speaker 1>the walkers, the blah blah blah.

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<v Speaker 3>Walker or I think it depends on the group, Like

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<v Speaker 3>every sort of group that runs around has their own

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<v Speaker 3>name for it.

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<v Speaker 1>Which is so unrealistic. Bro, everyone knows it's a freaking zombie.

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<v Speaker 2>Well so I think. I think in later, later movies

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<v Speaker 2>in between that time, they were called zombies and a

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<v Speaker 2>lot of them so annoys me. Well, it was actually

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<v Speaker 2>so George Romeiro only used the terms like ghouls or

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<v Speaker 2>flesh eaters when he made this movie, and he didn't

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<v Speaker 2>really encounter the term zombie until critics started using it

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<v Speaker 2>when describing the film, So it was really only then

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<v Speaker 2>when he was like, oh, these ares like and he

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<v Speaker 2>had taken clearly from zombie fictions. But I think it

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<v Speaker 2>sort of he put two and two together after the fact.

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<v Speaker 1>So he didn't know he was making the zombie movie

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<v Speaker 1>until after it was already made.

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<v Speaker 2>Well, no, I don't think that's necessarily true. I just

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<v Speaker 2>don't know if he would have called them zombies or

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<v Speaker 2>a brand new creature, because he did definitely take from

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<v Speaker 2>zombie fascinating films.

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<v Speaker 1>Okay, so okay, So if.

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<v Speaker 2>You haven't seen the movie, which Aaron and I just

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<v Speaker 2>watched it yesterday for research, the plot revolves around a

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<v Speaker 2>group of people hiding out in a house somewhere in

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<v Speaker 2>Pennsylvania as reanimated corpses due to a radiation accident around

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<v Speaker 2>the house. This movie effectively began or created an entire

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<v Speaker 2>new subgenre of horror movie. Romero and his co writer

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<v Speaker 2>John Russo drew from a bunch of sources, as I mentioned,

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<v Speaker 2>for inspiration, including a zombie called White Zombie, which I'll

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<v Speaker 2>talk more about later, and I am legend the book

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<v Speaker 2>by Richard Matheson about a plague of vampires. But Night

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<v Speaker 2>of the Living Dead was something really brand new in

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<v Speaker 2>many ways. This was the first movie to depict zombies

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<v Speaker 2>as flesh eating, as outnumbering people, as not controlled by

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<v Speaker 2>an outside force, as being contagious, and a government struggling

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<v Speaker 2>to maintain control. This was a far cry from the

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<v Speaker 2>early depictions of zombies and Hollywood movies. This movie, in

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<v Speaker 2>many zombie movies that followed, used zombies as a metaphor

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<v Speaker 2>for whatever was really threatening society or humanity, such as

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<v Speaker 2>unchecked consumerism, the violence of Vietnam War or the resistance

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<v Speaker 2>against America, the threat of nuclear war, racial inequality, and

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<v Speaker 2>so on. In modern zombie movies, zombies are used to

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<v Speaker 2>expose the true nature of humanity. How are people going

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<v Speaker 2>to react in a crisis. And it's not just using

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<v Speaker 2>zombies as this apocalyptic backdrop. The zombies themselves are scary

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<v Speaker 2>because they occupy this uncanny valley where the familiar appearance

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<v Speaker 2>of your neighbors or friends or spouse or child suddenly

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<v Speaker 2>becomes horrifying when they're trying to eat your brains all

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<v Speaker 2>of a sudden.

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<v Speaker 1>Yeah, then you have to shoot them in the head.

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<v Speaker 3>Yeah, I feel it's a pretty common trope. Right, There's

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<v Speaker 3>always that moment where you know there's a zombie horde

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<v Speaker 3>and they're trying to get away, and then you see

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<v Speaker 3>the face in the hoard that's you know, your best

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<v Speaker 3>friend or you know the person who you used to love,

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<v Speaker 3>and you're like, oh, but but Susie, how could And

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<v Speaker 3>then Susie like chomps down on your jugular and then.

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<v Speaker 5>Yeah, you're done.

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<v Speaker 2>Yeah so, and all of these characteristics of modern zombie

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<v Speaker 2>movies have the end result of making you scared of zombies,

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<v Speaker 2>not of becoming a zombie. So you're more scared of

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<v Speaker 2>the zombies attacking you rather than of actually becoming one.

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<v Speaker 1>I feel interesting.

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<v Speaker 2>So before Night of the Living Dead, though the perception

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<v Speaker 2>of zombies in Western culture was totally different, the modern

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<v Speaker 2>zombie actually has its roots in Haiti. And to understand

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<v Speaker 2>how the Haitian zombie was warped and misappropriated into what

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<v Speaker 2>we know as a zombie today, we have to go

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<v Speaker 2>back a bit to the history of Haiti itself. Also,

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<v Speaker 2>I just want to say that I'm totally out of

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<v Speaker 2>my depth here and I'm probably gonna miss some stuff,

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<v Speaker 2>but I'm gonna do the best I can, So if

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<v Speaker 2>there are any corrections, please.

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<v Speaker 1>Way yeah, Okay.

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<v Speaker 2>At the beginning, Christopher Columbus Great Guy y Well hand

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<v Speaker 2>it on the island of Hispaniola, which Haiti is the

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<v Speaker 2>western third of Hispaniola, which with the eastern two third

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<v Speaker 2>being the Dominican Republic. During his first trans oceanic voyage

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<v Speaker 2>in fourteen ninety two, as you can imagine, he instantly

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<v Speaker 2>claimed it for Spain, set up camps there, and introduced

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<v Speaker 2>diseases that led to nearly the entire indigenous population of

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<v Speaker 2>Taino and Arouak being wiped out.

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<v Speaker 1>Check our smallpox episode three if you are interested in more.

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<v Speaker 2>Uh huh, and with many of the rest of the

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<v Speaker 2>indigenous population being enslaved. Over the next couple of centuries, French,

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<v Speaker 2>English and Dutch pirates set up bases on the remote

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<v Speaker 2>western and northern coast of Hispaniola, which grew as a

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<v Speaker 2>trading hub throughout the sixteen hundreds while Spanish control lessened.

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<v Speaker 2>In the early seventeen hundreds, the French had taken control

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<v Speaker 2>of the western part, which would later become Haiti. They

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<v Speaker 2>ramped up export and production, and by the mid seventeen

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<v Speaker 2>hundred the small piece of land was responsible for producing

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<v Speaker 2>sixty percent of the world's coffee whoa yeah, and more

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<v Speaker 2>sugar than all the British Caribbean possessions quote unquote combined.

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<v Speaker 1>WHOA, dude, Yeah, I didn't know any of that.

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<v Speaker 2>Can you guess how it got to be so productive? Uh?

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<v Speaker 2>Slave labor, unbelievable amounts of slave labor.

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<v Speaker 1>Yeah.

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<v Speaker 2>Slaves on these plantations were treated so terribly and forced

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<v Speaker 2>to live under such horrific conditions that at least seventeen

0:13:21.480 --> 0:13:25.640
<v Speaker 2>thousand slaves died each year. Whoa, and the death rate

0:13:25.800 --> 0:13:30.640
<v Speaker 2>outpassed the birth rate eight percent to one percent. Oh

0:13:30.640 --> 0:13:35.400
<v Speaker 2>my god, it's yeah. Every year the number of people

0:13:35.520 --> 0:13:38.240
<v Speaker 2>enslaved and taken from Africa to work in the French

0:13:38.240 --> 0:13:42.559
<v Speaker 2>colony increased, with around forty thousand slaves brought over every

0:13:42.679 --> 0:13:45.680
<v Speaker 2>year in the years leading up to the Haitian Revolution.

0:13:46.400 --> 0:13:49.720
<v Speaker 2>On the eve of the revolution, thirty two thousand white

0:13:49.720 --> 0:13:55.080
<v Speaker 2>colonists ruled over nearly five hundred thousand slaves, the majority

0:13:55.120 --> 0:13:58.079
<v Speaker 2>of which were born in Africa, like three quarters.

0:13:58.320 --> 0:14:01.280
<v Speaker 1>Whoa, dude, So they killed off everyone who lived there,

0:14:01.559 --> 0:14:04.319
<v Speaker 1>and then they just kept shipping over more human beings

0:14:04.360 --> 0:14:05.840
<v Speaker 1>that they just murdered.

0:14:07.760 --> 0:14:10.960
<v Speaker 2>Well, seventeen ninety one comes around, and this marks the

0:14:11.000 --> 0:14:14.360
<v Speaker 2>start of a twelve year revolution that would lead to

0:14:14.400 --> 0:14:18.080
<v Speaker 2>the formation of an independent Haiti, which was huge. This

0:14:18.240 --> 0:14:22.440
<v Speaker 2>was the second oldest independent nation in the Western hemisphere.

0:14:22.480 --> 0:14:25.000
<v Speaker 1>WHOA yeah, tell me the year again.

0:14:24.960 --> 0:14:27.200
<v Speaker 2>Seventeen ninety one marks the beginning.

0:14:26.800 --> 0:14:28.240
<v Speaker 1>Of that revolution, thank you.

0:14:29.000 --> 0:14:31.640
<v Speaker 2>So I talked a little bit actually about the Haitian

0:14:31.680 --> 0:14:34.440
<v Speaker 2>Revolution in our episode on yellow fever. Oh, and the

0:14:34.640 --> 0:14:38.680
<v Speaker 2>possible but debated role that that yellow fever played in

0:14:38.760 --> 0:14:43.040
<v Speaker 2>destroying French troops when trying to quash the rebellion. But so,

0:14:43.080 --> 0:14:45.800
<v Speaker 2>the takeaway from all of this is that the free

0:14:45.840 --> 0:14:49.040
<v Speaker 2>country of Haiti was largely composed of people who were

0:14:49.040 --> 0:14:51.880
<v Speaker 2>born in Africa and had fought very hard for their freedom.

0:14:52.520 --> 0:14:55.520
<v Speaker 2>In the decades leading up to the revolution, a religion

0:14:55.560 --> 0:14:59.520
<v Speaker 2>had taken shape to unify everyone, which drew heavily from

0:14:59.600 --> 0:15:03.080
<v Speaker 2>summer reigions in West Africa, including the fun people living

0:15:03.080 --> 0:15:06.800
<v Speaker 2>in the area we call Benin, the Yoruba people in Nigeria,

0:15:06.840 --> 0:15:11.080
<v Speaker 2>and the Congo peoples in Angola and Basayer. And also

0:15:11.720 --> 0:15:16.280
<v Speaker 2>this religion incorporated elements of Catholicism and indigenous Taino beliefs

0:15:16.280 --> 0:15:19.560
<v Speaker 2>and practices. WHOA yeah. So it was really kind of

0:15:19.560 --> 0:15:24.280
<v Speaker 2>this very interesting mix. And after the revolution, the US

0:15:24.280 --> 0:15:27.840
<v Speaker 2>and Europe effectively cut contact with Haiti. They were like, nope,

0:15:27.880 --> 0:15:30.640
<v Speaker 2>you're on your own, and they prevented trade from happening.

0:15:31.120 --> 0:15:33.920
<v Speaker 2>And they also didn't allow any Catholic priests to go

0:15:33.960 --> 0:15:36.760
<v Speaker 2>to the country, which the French had set up as

0:15:36.800 --> 0:15:40.800
<v Speaker 2>a Catholic colony. So, as a result, Haitian culture is

0:15:41.000 --> 0:15:46.320
<v Speaker 2>really strongly influenced by traditions and practices directly from different

0:15:46.320 --> 0:15:51.160
<v Speaker 2>African cultures, without this sustained colonial presence quashing these influences

0:15:51.200 --> 0:15:55.359
<v Speaker 2>the way some other Caribbean nations were Wow.

0:15:55.600 --> 0:15:55.880
<v Speaker 1>Yeah.

0:15:56.960 --> 0:16:02.560
<v Speaker 2>So this religion, or more accurately, experience continued to develop

0:16:02.640 --> 0:16:05.680
<v Speaker 2>and is known as as vodu to those outside of it.

0:16:06.400 --> 0:16:09.640
<v Speaker 2>So if you are someone who practices vodu, you don't

0:16:09.680 --> 0:16:13.680
<v Speaker 2>call it vodu. It's just your spiritual experience. It's serving

0:16:13.720 --> 0:16:17.520
<v Speaker 2>the spirits. I'm not going to go into any real

0:16:17.600 --> 0:16:20.400
<v Speaker 2>details of vodu because there are many great resources for that,

0:16:20.680 --> 0:16:23.360
<v Speaker 2>me not being one of them, but I will say

0:16:23.440 --> 0:16:27.240
<v Speaker 2>that vodu is this is this spiritual system focused on

0:16:27.480 --> 0:16:33.480
<v Speaker 2>healing and spirituality. Zombies or zombification are not a part

0:16:33.520 --> 0:16:37.720
<v Speaker 2>of vodu as it is practiced. Rather, zombie making is

0:16:37.760 --> 0:16:41.280
<v Speaker 2>considered a folk religious practice that derives from vodu, but

0:16:41.440 --> 0:16:43.880
<v Speaker 2>isn't a part of it, okay, So I just wanted

0:16:43.880 --> 0:16:47.480
<v Speaker 2>to make that clear. So what is a zombie then?

0:16:47.600 --> 0:16:50.000
<v Speaker 2>In Haitian culture? Great question.

0:16:52.360 --> 0:16:56.120
<v Speaker 1>I love that asked and answered and complimented.

0:16:57.640 --> 0:17:03.280
<v Speaker 2>Great it self compliments. Well, the word zombie probably came

0:17:03.280 --> 0:17:07.160
<v Speaker 2>from the West African and Congo words in zabie in zombie,

0:17:07.240 --> 0:17:10.399
<v Speaker 2>which is god or spirit of a dead person, and zombie,

0:17:10.600 --> 0:17:14.560
<v Speaker 2>which means fetish. A zombie is created by a boko,

0:17:14.800 --> 0:17:18.560
<v Speaker 2>which is basically a priest who practices sorcery. There are

0:17:18.600 --> 0:17:21.720
<v Speaker 2>two types of zombies. One is a zombie astrol, which

0:17:21.760 --> 0:17:24.520
<v Speaker 2>is the soul of a deceased person that the boko

0:17:24.640 --> 0:17:27.600
<v Speaker 2>can use to enhance his powers, and the other is

0:17:27.640 --> 0:17:29.840
<v Speaker 2>the one that we are more familiar with, the zombie

0:17:29.880 --> 0:17:33.560
<v Speaker 2>of flesh. This corporeal zombie is one who has either

0:17:33.640 --> 0:17:36.480
<v Speaker 2>been raised from the dead or is made to appear

0:17:36.560 --> 0:17:42.959
<v Speaker 2>dead and then awakened or reanimated by a boko. So

0:17:43.119 --> 0:17:46.200
<v Speaker 2>this zombie flesh has no will and is under complete

0:17:46.280 --> 0:17:48.919
<v Speaker 2>control by the bokhor who uses the zombie to do

0:17:49.000 --> 0:17:53.080
<v Speaker 2>his bidding, which often involves laboring in some way, and

0:17:53.160 --> 0:17:56.359
<v Speaker 2>so the threat of Haitian zombification is different than this

0:17:56.640 --> 0:17:59.800
<v Speaker 2>modern zombification as in the movies. The loss of a

0:18:00.480 --> 0:18:03.440
<v Speaker 2>being forced to work against your will, loss of contact

0:18:03.440 --> 0:18:06.520
<v Speaker 2>with family and loved ones. These are the consequences of

0:18:06.560 --> 0:18:09.480
<v Speaker 2>becoming a Haitian zombie, which makes sense for a country

0:18:09.520 --> 0:18:13.359
<v Speaker 2>with such a horrific history of slavery. In contrast with

0:18:13.400 --> 0:18:17.080
<v Speaker 2>the modern zombie, becoming a Haitian zombie is scarier than

0:18:17.119 --> 0:18:19.960
<v Speaker 2>the zombie itself, So you're more scared of becoming a

0:18:20.040 --> 0:18:21.520
<v Speaker 2>zombie than you are of the zombie.

0:18:21.640 --> 0:18:25.600
<v Speaker 1>Right, that does make sense. Yeah, I now understand how

0:18:25.800 --> 0:18:28.240
<v Speaker 1>why you made that distinction earlier because I was like,

0:18:28.359 --> 0:18:31.560
<v Speaker 1>I don't want to become a zombie because then you die.

0:18:31.680 --> 0:18:38.760
<v Speaker 2>But now it makes more so how did the modern

0:18:38.840 --> 0:18:43.560
<v Speaker 2>zombie evolve from this? Well? In characteristic manifest destiny form,

0:18:44.119 --> 0:18:48.200
<v Speaker 2>the US invaded unoccupied Haiti from nineteen fifteen to nineteen

0:18:48.280 --> 0:18:54.480
<v Speaker 2>thirty four. Classic During the occupation, a bunch of ethnographers

0:18:54.480 --> 0:18:57.720
<v Speaker 2>and writers, including Zora Neil Hurston, who wrote one of

0:18:57.760 --> 0:19:00.720
<v Speaker 2>the first books on Vhoto and Haitian culture, came to

0:19:00.800 --> 0:19:06.760
<v Speaker 2>Haiti and exported stories of zombies. Many were very sensationalized,

0:19:06.760 --> 0:19:09.960
<v Speaker 2>which kind of gave rise to this like fear and

0:19:10.119 --> 0:19:14.600
<v Speaker 2>otherness of vodoo in US culture and Western culture in general.

0:19:15.680 --> 0:19:18.560
<v Speaker 2>One of these stories was by a man named William Seabrook,

0:19:18.760 --> 0:19:22.840
<v Speaker 2>who wrote a sensationalist book called The Magic Island. In

0:19:22.880 --> 0:19:26.920
<v Speaker 2>one chapter, Seabrook describes seeing a zombie master controlling a

0:19:26.960 --> 0:19:30.640
<v Speaker 2>group of zombies to labor for free. This was turned

0:19:30.640 --> 0:19:34.439
<v Speaker 2>into a movie called White Zombie, which has all kinds

0:19:34.520 --> 0:19:38.399
<v Speaker 2>of racist and sexist I guess, not really undertones, like

0:19:38.920 --> 0:19:45.320
<v Speaker 2>overtones overtones, yes, sorry, so yeah. In White Zombie, the

0:19:45.440 --> 0:19:49.080
<v Speaker 2>zombies are catatonic and completely under control of the bocort,

0:19:49.400 --> 0:19:52.359
<v Speaker 2>and this was the prevailing image of zombies in Western

0:19:52.400 --> 0:19:55.439
<v Speaker 2>culture until Romero changed the game with Knight of the

0:19:55.440 --> 0:20:01.560
<v Speaker 2>Living Dead. Interesting, we're still though a piece of the puzzle,

0:20:01.880 --> 0:20:04.800
<v Speaker 2>which is the how of a zombie? So what is

0:20:04.800 --> 0:20:08.320
<v Speaker 2>the medical basis for zombification? Yeah, bro, and I think

0:20:08.440 --> 0:20:12.960
<v Speaker 2>it's also just an in passing. We're thinking about why

0:20:13.040 --> 0:20:16.640
<v Speaker 2>researchers and I'm including us in this, feel the need

0:20:16.680 --> 0:20:21.120
<v Speaker 2>to demystify some cultural or spiritual practices to reduce them

0:20:21.160 --> 0:20:24.239
<v Speaker 2>to compounds or chemicals or oh well, this happens. This

0:20:24.320 --> 0:20:26.600
<v Speaker 2>is how it can happen in reality, you know, And

0:20:26.640 --> 0:20:28.399
<v Speaker 2>that's just something to kind of I wanted to just

0:20:28.440 --> 0:20:30.600
<v Speaker 2>say to think about because it was kind of after

0:20:30.640 --> 0:20:33.680
<v Speaker 2>reading Wade Davis's books, I was like, why are you

0:20:34.080 --> 0:20:36.240
<v Speaker 2>why why?

0:20:36.359 --> 0:20:37.560
<v Speaker 1>Yeah, that's a good question.

0:20:38.040 --> 0:20:44.120
<v Speaker 2>Okay, So that aside. In general, back to zombies, there

0:20:44.200 --> 0:20:47.520
<v Speaker 2>are two basic ideas as to how zombies are created.

0:20:47.600 --> 0:20:49.000
<v Speaker 1>Okay, give them to me, okay.

0:20:49.440 --> 0:20:52.560
<v Speaker 2>One basically says this is Haitian zombies. One basically says

0:20:52.640 --> 0:20:56.560
<v Speaker 2>that zombies are created through spiritual belief and that often

0:20:56.640 --> 0:21:01.600
<v Speaker 2>so called zombies are cases of mental illness and deprivation.

0:21:02.760 --> 0:21:06.080
<v Speaker 2>The other focuses more on the medical basis of zombification.

0:21:07.320 --> 0:21:10.560
<v Speaker 2>Belonging to the second category is Wade Davis. As a

0:21:10.600 --> 0:21:13.600
<v Speaker 2>grad student, WAYE. Davis went down to Haiti in the

0:21:13.680 --> 0:21:18.080
<v Speaker 2>nineteen eighties seeking to uncover the truth about zombification, in

0:21:18.119 --> 0:21:21.240
<v Speaker 2>particular whether it exists at all and whether there was

0:21:21.280 --> 0:21:24.399
<v Speaker 2>a plant or animal based compound that can actually cause

0:21:24.440 --> 0:21:28.560
<v Speaker 2>a zombie like state in people. In his journeys, he

0:21:28.600 --> 0:21:31.159
<v Speaker 2>came across the story of a man whose name I

0:21:31.200 --> 0:21:35.200
<v Speaker 2>will definitely mess up the pronunciation of Clervius Narses.

0:21:36.640 --> 0:21:37.280
<v Speaker 1>I don't know you.

0:21:37.280 --> 0:21:42.439
<v Speaker 2>Tried who had emerged after years sixteen years actually of

0:21:42.480 --> 0:21:45.480
<v Speaker 2>allegedly being kept in a zombie like state and forced

0:21:45.480 --> 0:21:49.399
<v Speaker 2>to work. And he had been confirmed to have died

0:21:49.920 --> 0:21:53.120
<v Speaker 2>and been buried. So this was like nineteen sixty two,

0:21:53.240 --> 0:21:58.159
<v Speaker 2>I think is when he was buried and then only

0:21:58.520 --> 0:22:00.000
<v Speaker 2>to emerge sixteen years later.

0:22:00.640 --> 0:22:03.000
<v Speaker 1>Wait, he died and was buried in sixteen years later

0:22:03.040 --> 0:22:03.640
<v Speaker 1>he came up.

0:22:04.080 --> 0:22:08.600
<v Speaker 2>No, sixteen years later he sort of re emerged into society.

0:22:08.840 --> 0:22:12.560
<v Speaker 1>Society got it? Okay, he wasn't buried for sixteen years? No, no, no, no,

0:22:12.600 --> 0:22:17.080
<v Speaker 1>because I would call the sm well anyway.

0:22:17.400 --> 0:22:20.240
<v Speaker 2>So Davis sought to find out how this could have happened,

0:22:20.640 --> 0:22:23.200
<v Speaker 2>and he was able to gain access to various quote

0:22:23.280 --> 0:22:26.800
<v Speaker 2>zombie powders and to observe their preparation. The contents of

0:22:26.800 --> 0:22:29.439
<v Speaker 2>these powders varied region by region, but he found that

0:22:29.520 --> 0:22:33.560
<v Speaker 2>a few ingredients were always present, among them human remains,

0:22:34.240 --> 0:22:38.639
<v Speaker 2>cane toad, the hyla tree frog, and various species of

0:22:38.840 --> 0:22:43.960
<v Speaker 2>pufferfish puffle fish who say. In examining each of these,

0:22:44.520 --> 0:22:47.920
<v Speaker 2>he found one likely candidate for making someone appear dead,

0:22:48.240 --> 0:22:52.000
<v Speaker 2>the pufferfish, which contains a compound known as to trottoxin.

0:22:53.960 --> 0:22:57.320
<v Speaker 2>Davis alleged that this toxin, when given to the intended zombie,

0:22:57.520 --> 0:23:00.480
<v Speaker 2>could imitate death, so that the person could be buried

0:23:00.560 --> 0:23:03.320
<v Speaker 2>and then dug up and held under control by the

0:23:03.440 --> 0:23:10.200
<v Speaker 2>use of other compounds, including the datura plant. Aaron, please

0:23:10.720 --> 0:23:13.359
<v Speaker 2>tell us how to tret to talxin works and whether

0:23:13.560 --> 0:23:15.680
<v Speaker 2>it is the true zombie powder.

0:23:16.520 --> 0:23:17.240
<v Speaker 1>I love to.

0:23:34.040 --> 0:23:36.360
<v Speaker 2>I'm excited for this part because I avoided it.

0:23:36.320 --> 0:23:38.560
<v Speaker 1>And I was like, oh great, then let me tell

0:23:38.560 --> 0:23:40.720
<v Speaker 1>you about it. To trot to toxin.

0:23:42.000 --> 0:23:42.320
<v Speaker 2>Okay.

0:23:42.359 --> 0:23:44.879
<v Speaker 1>The thing is, as I started researching this, I was like,

0:23:46.040 --> 0:23:49.840
<v Speaker 1>we already did this. We've already done this episode. It's

0:23:49.920 --> 0:23:55.800
<v Speaker 1>called crossover with crossover. Yes, you already knew the answer. Yes,

0:23:55.880 --> 0:23:59.280
<v Speaker 1>if you haven't yet listened to our crossover episode with

0:23:59.359 --> 0:24:03.040
<v Speaker 1>Matt Candas of in Defensive Plants, where we discuss Monk's

0:24:03.080 --> 0:24:08.240
<v Speaker 1>Hood aka Wolf'spin, then go listen to that. You'll probably

0:24:08.280 --> 0:24:11.800
<v Speaker 1>like it because we're talking about something that has a

0:24:11.960 --> 0:24:16.960
<v Speaker 1>very similar mechanism of action. Interesting. Yes, and by very

0:24:17.000 --> 0:24:18.959
<v Speaker 1>similar I mean the same.

0:24:21.160 --> 0:24:26.359
<v Speaker 3>I did listen to that episode and it was absolutely amazing.

0:24:24.520 --> 0:24:31.080
<v Speaker 2>Okay, I cannot wait for the evolutionary history and I'm

0:24:31.119 --> 0:24:32.160
<v Speaker 2>excited for the medical press.

0:24:32.359 --> 0:24:34.560
<v Speaker 1>Okay, I'm going to speed through this because I can't

0:24:34.560 --> 0:24:39.280
<v Speaker 1>wait for the evolutionary history. That's what I want to hear. Listen. Okay,

0:24:39.720 --> 0:24:43.000
<v Speaker 1>so let me give you the briefest of rundowns to

0:24:43.160 --> 0:24:48.280
<v Speaker 1>trot to toxin acts on something called your sodium channels.

0:24:48.920 --> 0:24:54.159
<v Speaker 1>What that was cool of us? We didn't plan that.

0:24:56.280 --> 0:24:57.960
<v Speaker 3>It's less cool now that you've said it.

0:25:01.359 --> 0:25:04.600
<v Speaker 1>Again. If you want a primer on sodium channels. I

0:25:04.680 --> 0:25:07.120
<v Speaker 1>really feel like I did a great job explaining them

0:25:08.400 --> 0:25:11.400
<v Speaker 1>because I got real stoked on them in the last episode,

0:25:11.440 --> 0:25:15.080
<v Speaker 1>and you explained it really well. Thank you. Basically for

0:25:15.200 --> 0:25:16.920
<v Speaker 1>those of you who are like, stop talking about it,

0:25:16.960 --> 0:25:18.879
<v Speaker 1>I'm not going to go listen to that episode, or

0:25:18.920 --> 0:25:20.760
<v Speaker 1>like I listen to it and I don't remember think

0:25:20.760 --> 0:25:23.520
<v Speaker 1>because you did a crappy job of explaining it. Sodium

0:25:23.640 --> 0:25:27.119
<v Speaker 1>channels are these channels that are on your nerve cells

0:25:27.160 --> 0:25:31.000
<v Speaker 1>and your muscle cells, and you need to have them

0:25:31.160 --> 0:25:35.560
<v Speaker 1>open and close at certain times to have nervous system

0:25:35.640 --> 0:25:40.200
<v Speaker 1>impulses actually transmit to your muscle cells to cause things

0:25:40.240 --> 0:25:42.280
<v Speaker 1>like muscle contraction. So if you want to lift your

0:25:42.359 --> 0:25:45.119
<v Speaker 1>arm or move your finger or talk with your mouth.

0:25:45.560 --> 0:25:48.919
<v Speaker 1>You need these sodium channels to be working. That's the

0:25:48.920 --> 0:25:53.240
<v Speaker 1>briefest of rundowns I can give. So tichoto toxin is

0:25:53.280 --> 0:25:59.280
<v Speaker 1>a compound which binds directly to these sodium channels and.

0:25:59.280 --> 0:26:01.879
<v Speaker 2>Blocks That sounds pretty bad.

0:26:02.040 --> 0:26:06.440
<v Speaker 1>It's not great. Let me tell ya, it's not great.

0:26:06.680 --> 0:26:09.679
<v Speaker 1>It blocks them. And what that means is that sodium

0:26:09.800 --> 0:26:12.760
<v Speaker 1>can no longer get in. If sodium can't get in,

0:26:13.119 --> 0:26:18.280
<v Speaker 1>your nerve impulses are not traveling, your muscles are not contracting,

0:26:18.960 --> 0:26:25.399
<v Speaker 1>You're paralyzed. Yeah, that's exactly what it is. And the

0:26:25.480 --> 0:26:28.760
<v Speaker 1>thing that makes this different than aconite, which is the

0:26:29.440 --> 0:26:33.080
<v Speaker 1>compound in wolf Spain that we talked about in the crossovers, Matt,

0:26:33.440 --> 0:26:38.400
<v Speaker 1>is that it's way way more gnarly, way more potent.

0:26:39.000 --> 0:26:41.600
<v Speaker 1>What does that mean? Let me tell you. I wrote

0:26:41.600 --> 0:26:43.879
<v Speaker 1>some numbers down. Oh good, because I have fun with this.

0:26:46.760 --> 0:26:50.080
<v Speaker 1>If you could think of a compound that's really, really

0:26:50.160 --> 0:26:52.760
<v Speaker 1>poisonous that could kill you really easily, don't guess because

0:26:52.760 --> 0:26:55.080
<v Speaker 1>you might guess wrong. I'm gonna tell you it's cyanide.

0:26:58.960 --> 0:27:00.080
<v Speaker 1>Would you have guessed that?

0:27:00.600 --> 0:27:06.280
<v Speaker 2>We absolutely cool? So cyanide all the answers, all the time, cyanide.

0:27:06.359 --> 0:27:08.280
<v Speaker 3>You read my mind, Get out of my head.

0:27:09.359 --> 0:27:12.520
<v Speaker 1>So, cyanide is a compound that everyone knows. Like, if

0:27:12.560 --> 0:27:14.359
<v Speaker 1>you hear the word cyanide, even if you have no

0:27:14.480 --> 0:27:16.399
<v Speaker 1>idea how it works or what it does, you know, like,

0:27:16.560 --> 0:27:18.480
<v Speaker 1>don't like drink that it's going to kill you really

0:27:18.520 --> 0:27:25.400
<v Speaker 1>quickly apple seeds exactly. So if I wanted to kill myself, No,

0:27:25.640 --> 0:27:29.080
<v Speaker 1>if you wanted to kill me with cyanide, you would

0:27:29.119 --> 0:27:35.880
<v Speaker 1>need at least five hundred and forty six milligrams of cyanide.

0:27:36.000 --> 0:27:36.840
<v Speaker 2>What does that look like?

0:27:37.080 --> 0:27:42.960
<v Speaker 1>Well, great question. A teaspoon of salt is five ish grams,

0:27:43.280 --> 0:27:46.520
<v Speaker 1>So that's like five thousand milligrams. So it's a tiny amount. Okay,

0:27:46.520 --> 0:27:49.920
<v Speaker 1>So it's like a little like a tenth Yes, it's

0:27:49.960 --> 0:27:52.119
<v Speaker 1>a dash of cyanide. That's all you would need to

0:27:52.200 --> 0:27:52.520
<v Speaker 1>kill it.

0:27:52.520 --> 0:27:54.640
<v Speaker 2>Even a sprinkle less than a sprinkle.

0:27:54.320 --> 0:27:57.119
<v Speaker 1>Less than a sprink Okay, Okay. If you wanted to

0:27:57.200 --> 0:28:03.359
<v Speaker 1>kill me with techototoxin twenty two milligrams.

0:28:02.880 --> 0:28:04.240
<v Speaker 2>How would you even measure that out?

0:28:04.320 --> 0:28:06.119
<v Speaker 1>I don't. I'd really tried hard to think of a

0:28:06.160 --> 0:28:09.879
<v Speaker 1>way to like quantify this for people kill you to

0:28:10.000 --> 0:28:13.919
<v Speaker 1>kill me with tachot to toxin twenty two grams.

0:28:14.200 --> 0:28:15.800
<v Speaker 2>Wait wait wait grams are milligrams?

0:28:15.880 --> 0:28:16.920
<v Speaker 1>Sorry milligrams?

0:28:17.040 --> 0:28:17.679
<v Speaker 3>Whoa bro.

0:28:17.880 --> 0:28:19.720
<v Speaker 2>It was like, great, there's a lot of tea spins.

0:28:21.480 --> 0:28:26.960
<v Speaker 1>No, it's very few tea spoons. Yeah, right, So, and

0:28:27.000 --> 0:28:32.440
<v Speaker 1>the reason is because unlike aconite or other, there's actually

0:28:32.680 --> 0:28:35.600
<v Speaker 1>a ridiculous amount of toxins. And Shane, I don't know

0:28:35.640 --> 0:28:37.080
<v Speaker 1>if you're going to touch on this at all. I

0:28:37.119 --> 0:28:41.360
<v Speaker 1>have a feeling you are. How many different organisms produce

0:28:42.000 --> 0:28:44.440
<v Speaker 1>compounds which bind to sodium channels.

0:28:45.080 --> 0:28:48.240
<v Speaker 3>It's a lot, yea, it is a lot. Yeah, And

0:28:48.640 --> 0:28:52.080
<v Speaker 3>it's a very diverse set of creatures.

0:28:52.240 --> 0:28:56.640
<v Speaker 1>Yeah, which is so interesting because the thing is we

0:28:56.680 --> 0:28:59.160
<v Speaker 1>all have sodium channels. Like, like I said in the

0:28:59.160 --> 0:29:03.600
<v Speaker 1>Monk Said episode, insects have sodium channels, right, So it's

0:29:03.640 --> 0:29:07.000
<v Speaker 1>this very universal thing that if you can attack that

0:29:07.080 --> 0:29:11.880
<v Speaker 1>sodium channel, you can attack absolutely anything. So but to

0:29:12.000 --> 0:29:15.360
<v Speaker 1>Troto toxin is so good at binding to these sodium

0:29:15.440 --> 0:29:18.480
<v Speaker 1>channels that we actually classify sodium channels. There's a lot

0:29:18.520 --> 0:29:21.760
<v Speaker 1>of different types, like sort of subsets of sodium channels

0:29:21.800 --> 0:29:24.440
<v Speaker 1>that work better, Like these ones are on your muscles

0:29:24.440 --> 0:29:26.760
<v Speaker 1>and these ones are on your nerves. But there's kind

0:29:26.800 --> 0:29:32.160
<v Speaker 1>of two broad categories, one to trototoxin sensitive, one to

0:29:32.280 --> 0:29:38.000
<v Speaker 1>troto toxin resistant. That's how we classify sodium channels because

0:29:38.320 --> 0:29:41.720
<v Speaker 1>that's how strongly to troto talxin binds. So we basically,

0:29:42.080 --> 0:29:44.480
<v Speaker 1>like all of these different types of sodium channels, we

0:29:44.520 --> 0:29:47.600
<v Speaker 1>divide them into can to troto talksin bind or can

0:29:47.640 --> 0:29:50.320
<v Speaker 1>it not? Right? Isn't that cool?

0:29:50.400 --> 0:29:51.200
<v Speaker 2>That's amazing?

0:29:51.360 --> 0:29:57.040
<v Speaker 1>Yeah, it's super cool. Didn't So? I know, you really

0:29:57.080 --> 0:30:00.200
<v Speaker 1>want to know what happens to you if you take

0:30:00.200 --> 0:30:02.800
<v Speaker 1>a bite of a puffer fish, just like out of

0:30:02.800 --> 0:30:05.480
<v Speaker 1>the ocean, just like the liver, Give me the liver.

0:30:05.920 --> 0:30:10.040
<v Speaker 1>Here we go. If you ingest this, generally within a

0:30:10.080 --> 0:30:13.760
<v Speaker 1>half an hour, often less, the first symptom that you'll

0:30:13.800 --> 0:30:18.280
<v Speaker 1>have is parishesia, which is a fancy silly medical word

0:30:18.360 --> 0:30:23.200
<v Speaker 1>for your lips start tingling and they get a little numb,

0:30:23.320 --> 0:30:26.880
<v Speaker 1>and maybe they feel burning and like just like something's

0:30:26.920 --> 0:30:29.960
<v Speaker 1>not right in your lips. And then that might start

0:30:30.000 --> 0:30:33.840
<v Speaker 1>to spread, and then you might start salivating a lot,

0:30:34.520 --> 0:30:37.360
<v Speaker 1>and then you might start sweating, and then you'll get

0:30:37.400 --> 0:30:39.200
<v Speaker 1>a headache because you're like, what's going on to me?

0:30:39.240 --> 0:30:40.480
<v Speaker 1>And then you'll feel really weak.

0:30:40.720 --> 0:30:42.080
<v Speaker 2>Oh my God, it's like a subway.

0:30:42.120 --> 0:30:46.520
<v Speaker 1>And then you'll get sperienced subway sandwiches. Yes, not endorsed, guys.

0:30:49.040 --> 0:30:51.720
<v Speaker 2>That's because I've gotten food poisoning a number of times

0:30:51.920 --> 0:30:54.160
<v Speaker 2>subway sandwiches, and so far, that's what it sounds like.

0:30:54.200 --> 0:30:57.320
<v Speaker 1>Okay, well, and then you'll start to get a tremor

0:30:59.040 --> 0:31:00.840
<v Speaker 1>and then paralysis.

0:31:01.960 --> 0:31:04.680
<v Speaker 2>That's no good, no good.

0:31:04.960 --> 0:31:08.400
<v Speaker 1>And the thing that gets really dangerous and why this

0:31:08.520 --> 0:31:12.000
<v Speaker 1>ends up often causing death is if you have paralysis

0:31:12.040 --> 0:31:14.560
<v Speaker 1>of the muscles that you use for breathing, so your

0:31:14.640 --> 0:31:18.600
<v Speaker 1>diaphragm and your intercostal muscles of your ribs. If those

0:31:18.720 --> 0:31:24.240
<v Speaker 1>muscles become paralyzed, you cannot breathe. See our polio episode

0:31:24.360 --> 0:31:27.120
<v Speaker 1>for more on that question. Mm hmm.

0:31:27.720 --> 0:31:30.760
<v Speaker 2>So it starts in your lips, that's just the first symptom.

0:31:31.600 --> 0:31:33.840
<v Speaker 1>Yeah, it's often the first symptom. And that's if we're

0:31:33.840 --> 0:31:37.240
<v Speaker 1>talking about someone who's eaten fugu or a puffer fish,

0:31:37.320 --> 0:31:39.560
<v Speaker 1>and that is often the first symptom. And it's because

0:31:39.560 --> 0:31:42.760
<v Speaker 1>that's sort of the first place where you're gonna encounter

0:31:42.840 --> 0:31:43.560
<v Speaker 1>to trot to toxin.

0:31:43.680 --> 0:31:45.120
<v Speaker 2>Improperly prepared fugu.

0:31:45.320 --> 0:31:48.520
<v Speaker 1>Yes, improperly prepared fugu. Right, So like you caught a

0:31:48.520 --> 0:31:50.320
<v Speaker 1>puffer fish and you took a bite out of it

0:31:50.520 --> 0:31:51.080
<v Speaker 1>like an apple.

0:31:51.280 --> 0:31:51.400
<v Speaker 4>Right.

0:31:51.600 --> 0:31:53.800
<v Speaker 1>Then the first place that you'll start to notice symptoms

0:31:53.840 --> 0:31:55.880
<v Speaker 1>is in your mouth, but then quickly you'll also get

0:31:56.000 --> 0:32:02.440
<v Speaker 1>gastro intentional symptoms, nausea, vomiting, diarrhea. But again, what ends

0:32:02.520 --> 0:32:06.600
<v Speaker 1>up killing people is respiratory distress. Right, So you're not

0:32:06.760 --> 0:32:10.240
<v Speaker 1>able to breathe because all of the muscles of your

0:32:10.240 --> 0:32:15.200
<v Speaker 1>respiratory tract have failed and they're paralyzed, and then you die.

0:32:15.280 --> 0:32:18.239
<v Speaker 2>That sounds like a really horrible way to go.

0:32:18.360 --> 0:32:21.600
<v Speaker 1>It's not a great I wouldn't recommend it, and it

0:32:21.680 --> 0:32:26.080
<v Speaker 1>happens insanely quickly. And part of that's because it's this toxin. Right,

0:32:26.080 --> 0:32:29.400
<v Speaker 1>it's already, it's there, it's pre formed. You just eat

0:32:29.440 --> 0:32:34.880
<v Speaker 1>it or whatever. But you don't have to just eat it. Right,

0:32:35.320 --> 0:32:39.440
<v Speaker 1>what's the preparation that's most commonly associated with zombies? Older?

0:32:40.480 --> 0:32:41.800
<v Speaker 2>I was about to ask you that.

0:32:43.400 --> 0:32:46.760
<v Speaker 1>Be to to do it. So most people come into

0:32:46.800 --> 0:32:50.560
<v Speaker 1>contact with tatroto toxin by eating it, right, that's like

0:32:50.760 --> 0:32:56.200
<v Speaker 1>the most common. But because we're not talking about a

0:32:56.280 --> 0:32:59.560
<v Speaker 1>bacteria or a virus like we normally are, we're talking

0:32:59.600 --> 0:33:03.720
<v Speaker 1>about a compound that it's actually produced by bacteria. It's

0:33:03.720 --> 0:33:07.840
<v Speaker 1>a toxin because it's already something that's formed. You can

0:33:07.960 --> 0:33:12.000
<v Speaker 1>take a puffer fish, take its liver, dry it out,

0:33:12.480 --> 0:33:15.719
<v Speaker 1>grind it up into powder, blow it into someone's face,

0:33:15.840 --> 0:33:19.440
<v Speaker 1>and absolutely expose them to the toxin in that way.

0:33:19.520 --> 0:33:21.760
<v Speaker 1>So it's not necessary that it's ingested.

0:33:22.640 --> 0:33:26.480
<v Speaker 3>So is it just contact with like like mucous membrane

0:33:26.680 --> 0:33:28.880
<v Speaker 3>like eyes and nose and mouth.

0:33:29.160 --> 0:33:32.280
<v Speaker 1>Yes, And I'm so glad you brought that up. Shame

0:33:32.960 --> 0:33:36.680
<v Speaker 1>because this is a toxin that is way more deadly,

0:33:37.160 --> 0:33:39.800
<v Speaker 1>for example, if it's injected. So most of the studies

0:33:39.840 --> 0:33:43.040
<v Speaker 1>on this are done in mice, so they'll inject mice

0:33:43.560 --> 0:33:47.120
<v Speaker 1>with the tatototoxin. It's far more dangerous if you inject

0:33:47.160 --> 0:33:49.400
<v Speaker 1>a mouse versus if you let a mouse just nibble

0:33:49.440 --> 0:33:53.920
<v Speaker 1>on a pufferfish. Okay, same thing. I would assume. I

0:33:53.960 --> 0:33:56.280
<v Speaker 1>couldn't find evidence of this, but I think that's because

0:33:56.280 --> 0:34:01.719
<v Speaker 1>they don't often just like blow to torototoxin into mouse faces.

0:34:03.000 --> 0:34:06.240
<v Speaker 1>But you could one could assume that most of the

0:34:06.280 --> 0:34:11.080
<v Speaker 1>ways that people quote unquote detoxify things, which the way

0:34:11.080 --> 0:34:12.960
<v Speaker 1>that you do that is with your liver. So if

0:34:13.000 --> 0:34:17.719
<v Speaker 1>you eat something, then your gas to intestinal tract absorbs

0:34:17.719 --> 0:34:19.840
<v Speaker 1>it and it has to go through your liver, which

0:34:20.280 --> 0:34:23.799
<v Speaker 1>takes care of a lot of the problem. Okay, if

0:34:23.840 --> 0:34:26.360
<v Speaker 1>you inject it straight into your bloodstream or you breathe

0:34:26.400 --> 0:34:29.960
<v Speaker 1>it straight into your nose, which basically goes straight into

0:34:30.000 --> 0:34:34.680
<v Speaker 1>your blood through your mucous membranes, you don't have that

0:34:34.840 --> 0:34:39.000
<v Speaker 1>liver detoxification happening. So it's actually a lot more potent.

0:34:39.239 --> 0:34:41.840
<v Speaker 1>So it's a lot more dangerous to inhale is a

0:34:41.840 --> 0:34:45.799
<v Speaker 1>lot more Yeah. Well, okay, I couldn't find like specific

0:34:45.840 --> 0:34:48.799
<v Speaker 1>evidence of that, because again I couldn't find studies where

0:34:48.800 --> 0:34:52.240
<v Speaker 1>they blew to troy totoxinon mice. But what I based

0:34:52.280 --> 0:34:54.600
<v Speaker 1>on what I know about how things work. For example,

0:34:54.600 --> 0:34:59.520
<v Speaker 1>if you take drugs sublingually or by an inhaler sublingually

0:34:59.560 --> 0:35:03.640
<v Speaker 1>is under tongue rather than swallowing it down, it's more

0:35:03.960 --> 0:35:07.120
<v Speaker 1>rapidly gets into your bloodstream than if you eat something

0:35:07.120 --> 0:35:09.480
<v Speaker 1>and it has to go through your gi tracks. Yeah.

0:35:10.160 --> 0:35:13.280
<v Speaker 3>Can I just say, like, blowing to toro to toxin

0:35:13.400 --> 0:35:15.680
<v Speaker 3>into the face of a mouse is like the most

0:35:15.719 --> 0:35:18.279
<v Speaker 3>depressing lab job I have ever heard of in.

0:35:18.239 --> 0:35:21.960
<v Speaker 2>My Can you imagine if you sneeze and inhale.

0:35:22.239 --> 0:35:27.920
<v Speaker 3>Like, oh my goodness. If there's a hell, that's pretty

0:35:27.960 --> 0:35:31.359
<v Speaker 3>much the quickest way to get there is the accepted job,

0:35:31.680 --> 0:35:33.840
<v Speaker 3>like blowing to trot to toxin in the face of

0:35:34.360 --> 0:35:34.919
<v Speaker 3>lab mice.

0:35:35.120 --> 0:35:35.319
<v Speaker 5>Yeah.

0:35:35.680 --> 0:35:38.560
<v Speaker 1>Yeah, But so really, what the question that we have

0:35:38.600 --> 0:35:41.640
<v Speaker 1>to answer then is what does that have to do

0:35:41.680 --> 0:35:42.240
<v Speaker 1>with zombies?

0:35:42.280 --> 0:35:42.400
<v Speaker 3>Right?

0:35:42.480 --> 0:35:44.160
<v Speaker 1>Nothing that I said was like and then you go

0:35:44.560 --> 0:35:49.000
<v Speaker 1>you bite people or or even like you become controlled

0:35:49.040 --> 0:35:51.640
<v Speaker 1>by these powers, right, you get paralyzed and then you

0:35:51.760 --> 0:35:55.359
<v Speaker 1>die because you can't breathe, Like, that's that's what happens, right,

0:35:55.840 --> 0:35:59.279
<v Speaker 1>So why how could this have become a thing that

0:35:59.280 --> 0:36:02.920
<v Speaker 1>people associate zombie ism? And I'm really glad that you

0:36:03.440 --> 0:36:08.520
<v Speaker 1>mentioned how zombies in this non George Romero idea, it's

0:36:08.560 --> 0:36:11.920
<v Speaker 1>not like wanting your flesh and blood. It's being under

0:36:12.200 --> 0:36:17.160
<v Speaker 1>someone else's power. It's also being dead and coming back

0:36:17.360 --> 0:36:22.160
<v Speaker 1>to life. Now that to chot to toxin can do

0:36:23.040 --> 0:36:23.680
<v Speaker 1>kind of.

0:36:25.080 --> 0:36:25.400
<v Speaker 5>Hmmm.

0:36:26.560 --> 0:36:30.880
<v Speaker 1>So I got thrilled when I learned about this. So

0:36:31.160 --> 0:36:34.000
<v Speaker 1>one of the weird things about totot to toxin from

0:36:34.040 --> 0:36:37.360
<v Speaker 1>what I've read, is that when all of this is

0:36:37.400 --> 0:36:43.360
<v Speaker 1>happening to you, you remain conscious. Oh doesn't that sound awful? God?

0:36:43.800 --> 0:36:47.400
<v Speaker 1>Which explains a lot, but keep going. Yes, so you

0:36:47.600 --> 0:36:51.080
<v Speaker 1>are aware of what's happening to you. But it can

0:36:51.120 --> 0:36:54.400
<v Speaker 1>have such a drastic effect because again the sodium channels

0:36:54.400 --> 0:36:56.880
<v Speaker 1>are everywhere. It can have such a drastic effect on

0:36:56.920 --> 0:37:01.120
<v Speaker 1>your respiratory rate and your heart rate that you seem

0:37:01.680 --> 0:37:07.080
<v Speaker 1>like you're dead. So you can appear, for all intents

0:37:07.120 --> 0:37:11.640
<v Speaker 1>and purposes, essentially dead if you've been dosed with the

0:37:11.719 --> 0:37:15.680
<v Speaker 1>right amount of tetrototoxin where it's not completely paralyzing you right,

0:37:15.760 --> 0:37:18.920
<v Speaker 1>like your brainstem is still working. There's enough function in

0:37:18.960 --> 0:37:23.520
<v Speaker 1>your diaphragm that your unconscious breathing is still breathing, and

0:37:23.560 --> 0:37:26.080
<v Speaker 1>your heart is beating just enough to keep you alive,

0:37:26.200 --> 0:37:31.560
<v Speaker 1>but maybe not enough to show a pulse, which can happen. Wow. Yeah,

0:37:32.080 --> 0:37:36.839
<v Speaker 1>And so people can then pronounce you dead, and your

0:37:36.840 --> 0:37:41.640
<v Speaker 1>family can think you're dead because you know, you started

0:37:41.719 --> 0:37:44.319
<v Speaker 1>vomiting and diarrhea ing, and then you kind of went

0:37:44.440 --> 0:37:47.520
<v Speaker 1>limp and paralytic, and now you're not moving. It doesn't

0:37:47.520 --> 0:37:51.480
<v Speaker 1>seem like you're breathing. You must be dead. How long

0:37:52.200 --> 0:37:55.640
<v Speaker 1>great question? This can last. So symptoms tend to set

0:37:55.640 --> 0:37:58.719
<v Speaker 1>in very quickly, like within ten to thirty minutes. It

0:37:58.800 --> 0:38:01.719
<v Speaker 1>can it can take hours also, so if you haven't

0:38:01.840 --> 0:38:05.759
<v Speaker 1>ingested a lot and you know whatever, it can take

0:38:05.840 --> 0:38:09.120
<v Speaker 1>a longer time if you ingest it versus inject it,

0:38:09.320 --> 0:38:15.600
<v Speaker 1>et cetera. But when people do recover over a period

0:38:15.600 --> 0:38:18.960
<v Speaker 1>of many hours, maybe twenty four hours or more, they

0:38:19.000 --> 0:38:24.720
<v Speaker 1>recover completely. If you live, if you survive, you recover completely.

0:38:24.760 --> 0:38:28.440
<v Speaker 1>There's no neurological deficits. So once this totototoxin sort of

0:38:28.480 --> 0:38:30.719
<v Speaker 1>just makes its way out of your system, there's no

0:38:30.800 --> 0:38:32.160
<v Speaker 1>residual effects of it.

0:38:32.239 --> 0:38:34.719
<v Speaker 2>So it's like the Otown song all or nothing at all.

0:38:44.480 --> 0:38:47.160
<v Speaker 1>Oh my god. Yeah, sure, yeah, just.

0:38:47.120 --> 0:38:54.200
<v Speaker 3>Saying that, that's so even that's it's interesting that they're

0:38:54.400 --> 0:38:55.680
<v Speaker 3>like because I would think that there would be at

0:38:55.719 --> 0:38:59.239
<v Speaker 3>least some effects of like hypoxia, you know, having like

0:38:59.320 --> 0:39:02.560
<v Speaker 3>such a you know, having your your tissues or brain

0:39:02.640 --> 0:39:06.080
<v Speaker 3>being deprived of oxygen if you're not breathing very very

0:39:06.120 --> 0:39:09.280
<v Speaker 3>deeply or very often, and if your heart's not pumping

0:39:09.360 --> 0:39:12.120
<v Speaker 3>very often, I'd imagine there'd be at least some effects

0:39:12.160 --> 0:39:15.600
<v Speaker 3>from from just like hypoxia and not getting enough oxen.

0:39:15.640 --> 0:39:19.000
<v Speaker 1>Yeah, but it seems like you either die or you

0:39:19.080 --> 0:39:20.040
<v Speaker 1>recover completely.

0:39:21.440 --> 0:39:22.680
<v Speaker 2>That's bizarre.

0:39:22.719 --> 0:39:27.279
<v Speaker 1>It's super bizarre. I will say that if your respiratory

0:39:27.320 --> 0:39:30.799
<v Speaker 1>muscles are affected, it's not a good sign. You're you're

0:39:30.800 --> 0:39:35.120
<v Speaker 1>probably pretty much gonna die. Almost everyone who if the

0:39:35.160 --> 0:39:37.759
<v Speaker 1>paralysis spreads all the way to your diaphram, you're you're

0:39:37.800 --> 0:39:41.080
<v Speaker 1>probably going to die. So here's the thing, this is,

0:39:41.160 --> 0:39:44.440
<v Speaker 1>it's a gray area. It's not I wouldn't say I

0:39:44.520 --> 0:39:49.400
<v Speaker 1>buy it one hundred percent that like you could pronounce

0:39:49.440 --> 0:39:53.839
<v Speaker 1>somebody dead because they dosed them with tetototoxin. But it's

0:39:53.880 --> 0:39:58.879
<v Speaker 1>been used a ton in like popular culture, as I'm

0:39:58.920 --> 0:40:01.040
<v Speaker 1>going to fake someone's death, you know, like that happens

0:40:01.040 --> 0:40:04.960
<v Speaker 1>all the time. They do it with tatototoxin, often in movies.

0:40:05.640 --> 0:40:07.799
<v Speaker 3>I do feel like that's a very common trope. And

0:40:07.840 --> 0:40:10.680
<v Speaker 3>I could also see, you know, back in you know,

0:40:10.920 --> 0:40:14.160
<v Speaker 3>the early like late eighteen hundreds, early nineteen hundreds or

0:40:14.160 --> 0:40:17.680
<v Speaker 3>even earlier than that. I could certainly imagine a doctor like, oh, well,

0:40:17.719 --> 0:40:20.719
<v Speaker 3>he seems dead. Threw up and pooed himself and he's

0:40:20.760 --> 0:40:23.200
<v Speaker 3>not moving, and I don't want touch him because he

0:40:23.239 --> 0:40:25.839
<v Speaker 3>threw up and pooed himself, right, so just call him

0:40:25.880 --> 0:40:26.279
<v Speaker 3>dead and.

0:40:27.680 --> 0:40:31.040
<v Speaker 1>Ekg's we didn't have brain scanners, we didn't have like,

0:40:31.640 --> 0:40:36.200
<v Speaker 1>you can very easily survive if you're breathing, like there's

0:40:36.200 --> 0:40:40.360
<v Speaker 1>a lot of different breath types that are really not good.

0:40:40.400 --> 0:40:43.160
<v Speaker 1>But we'll get your body enough oxygen and release enough

0:40:43.200 --> 0:40:46.399
<v Speaker 1>CHROMEA dioxide. But might seem like you're not breathing because

0:40:46.400 --> 0:40:50.320
<v Speaker 1>you're breathing so infrequently, But if your heart is still pounding,

0:40:50.400 --> 0:40:54.200
<v Speaker 1>however weak it might be, then the blood is still flowing.

0:40:54.320 --> 0:40:57.399
<v Speaker 1>Then things are still getting oxygen. That I agree. If

0:40:57.440 --> 0:41:00.239
<v Speaker 1>you are in the seventeen hundreds and you're like, you

0:41:00.320 --> 0:41:02.480
<v Speaker 1>touch them and you're like, oh, they're kind of cold.

0:41:03.280 --> 0:41:05.279
<v Speaker 1>They must be dead, you know, and.

0:41:05.200 --> 0:41:07.279
<v Speaker 2>The stethoscope isn't invented.

0:41:07.560 --> 0:41:10.160
<v Speaker 1>Oh, I don't know. Don't ask me that, but I guess.

0:41:10.200 --> 0:41:12.319
<v Speaker 3>Also the trade off is that is that you know,

0:41:12.400 --> 0:41:15.120
<v Speaker 3>if you're not if you're like completely still in comatas

0:41:15.160 --> 0:41:17.680
<v Speaker 3>you actually you don't need as much oxygen as you

0:41:17.680 --> 0:41:20.359
<v Speaker 3>would if you were like up and moving around, so

0:41:20.440 --> 0:41:23.040
<v Speaker 3>you have this lower metabolic rate as well, so you're

0:41:23.560 --> 0:41:26.800
<v Speaker 3>you're using less oxygen so you don't need as much boom.

0:41:27.320 --> 0:41:32.480
<v Speaker 2>So zombies biology zombies boom. But is it boom or

0:41:32.560 --> 0:41:35.359
<v Speaker 2>is it just like, yeah, it is.

0:41:35.400 --> 0:41:38.279
<v Speaker 1>That's the thing, because it's like, okay, that's it's an

0:41:38.360 --> 0:41:41.960
<v Speaker 1>almost Maybe I could kind of buy it. Explanation for

0:41:42.040 --> 0:41:45.399
<v Speaker 1>how someone could be appearing dead and then come back

0:41:45.440 --> 0:41:51.480
<v Speaker 1>to life beyond that nothing like there's no like and

0:41:51.520 --> 0:41:55.040
<v Speaker 1>then you will succumb to my will or on the

0:41:55.080 --> 0:41:58.040
<v Speaker 1>other end, then you will eat flesh of humans, you know,

0:41:58.400 --> 0:41:58.799
<v Speaker 1>none of that.

0:41:58.960 --> 0:42:03.719
<v Speaker 2>So but the other thing is is it biable? Can

0:42:03.760 --> 0:42:07.239
<v Speaker 2>you reliably make a zombie powder?

0:42:07.360 --> 0:42:09.919
<v Speaker 1>No? I don't even fully buy that you could make

0:42:10.600 --> 0:42:14.239
<v Speaker 1>a powder period that you could be sure would just

0:42:15.440 --> 0:42:18.040
<v Speaker 1>kind of paralyze someone to the point that you could

0:42:18.160 --> 0:42:20.879
<v Speaker 1>convince someone else that they're dead, but then make sure

0:42:20.920 --> 0:42:23.919
<v Speaker 1>that they recover afterwards. Not dude, Yeah, I don't buy

0:42:23.960 --> 0:42:27.720
<v Speaker 1>it in the slightest, Like you could if you worked

0:42:27.760 --> 0:42:31.440
<v Speaker 1>really hard, probably convince people that you faked your death

0:42:32.239 --> 0:42:33.600
<v Speaker 1>by using this. Maybe.

0:42:33.680 --> 0:42:36.919
<v Speaker 3>I don't know that I was gonna ask, so when

0:42:37.239 --> 0:42:41.840
<v Speaker 3>when a person does recover, like what has happened? Like,

0:42:41.880 --> 0:42:45.960
<v Speaker 3>how does the tatro de toxin unbind from.

0:42:45.320 --> 0:42:48.160
<v Speaker 1>That's really a good question. I don't I don't know.

0:42:48.480 --> 0:42:51.440
<v Speaker 1>I mean, I guess it just eventually something will come

0:42:51.440 --> 0:42:54.640
<v Speaker 1>by and be able to degrade it. But I don't

0:42:54.680 --> 0:42:57.080
<v Speaker 1>have a full answer to that, because it from what

0:42:57.200 --> 0:43:03.480
<v Speaker 1>I can understand, it's not like a reversible binding, right,

0:43:03.560 --> 0:43:05.600
<v Speaker 1>like it binds and then it's bound. So it's either

0:43:05.680 --> 0:43:07.840
<v Speaker 1>just like your body has to make some new sodium

0:43:07.880 --> 0:43:11.799
<v Speaker 1>channels maybe and maybe your body can make enough to compensate,

0:43:12.320 --> 0:43:16.200
<v Speaker 1>or eventually, like nothing in your body is going to

0:43:16.280 --> 0:43:19.520
<v Speaker 1>last forever, right, so eventually, like that sodium channel will

0:43:19.520 --> 0:43:23.160
<v Speaker 1>be recycled or something, some macrophage will come by and

0:43:23.200 --> 0:43:26.279
<v Speaker 1>like snag up that to toototoxin or whatever. I don't

0:43:26.280 --> 0:43:29.239
<v Speaker 1>actually know the mechanism of it. I'm just making things

0:43:29.280 --> 0:43:30.040
<v Speaker 1>up right now.

0:43:30.160 --> 0:43:31.960
<v Speaker 3>But generating hypotheses.

0:43:32.040 --> 0:43:36.319
<v Speaker 1>There we go. I like that. But that is it

0:43:36.360 --> 0:43:38.360
<v Speaker 1>brings up a good point in that we don't have

0:43:38.400 --> 0:43:41.920
<v Speaker 1>any treatment for it. So the only thing you can

0:43:41.960 --> 0:43:45.319
<v Speaker 1>really do is if you know that someone ate a

0:43:45.320 --> 0:43:48.080
<v Speaker 1>puffer fish and they shouldn't have, you can like give

0:43:48.080 --> 0:43:51.080
<v Speaker 1>them activated charcoal or do a gastric levage, like make

0:43:51.120 --> 0:43:54.600
<v Speaker 1>them barf it all up, and that can help somewhat.

0:43:54.880 --> 0:43:59.200
<v Speaker 3>That is a very fancy word for barf inducing gastric levage.

0:43:59.600 --> 0:44:03.680
<v Speaker 1>But there aren't any treatments. So wow, well, people have

0:44:04.160 --> 0:44:07.480
<v Speaker 1>people have tried different things. I don't want to take

0:44:07.520 --> 0:44:09.040
<v Speaker 1>too much time, so I don't want to get into

0:44:09.120 --> 0:44:12.839
<v Speaker 1>like the various specific things that people have tried. They

0:44:12.840 --> 0:44:19.200
<v Speaker 1>don't work all that well. But here's my question. Clearly,

0:44:20.080 --> 0:44:24.759
<v Speaker 1>this mechanism of action of involving sodium channels, it's not

0:44:24.840 --> 0:44:28.400
<v Speaker 1>something new, right, pufferfish didn't invent this by any means.

0:44:28.880 --> 0:44:31.840
<v Speaker 1>We've already talked about it with wolf Spain. We'll probably

0:44:31.840 --> 0:44:34.160
<v Speaker 1>talk about it in the future with something else that

0:44:34.200 --> 0:44:38.640
<v Speaker 1>binds to the same channels. But the thing about tatrototoxin

0:44:39.000 --> 0:44:45.720
<v Speaker 1>that makes it so forking terrifying is that it's so potent.

0:44:45.800 --> 0:44:48.359
<v Speaker 1>It's so potent that we named the channels after it,

0:44:49.160 --> 0:44:53.120
<v Speaker 1>and the tiniest amount twenty two micrograms can kill me

0:44:53.560 --> 0:44:57.480
<v Speaker 1>a full grown human, right, twenty two milligrams? Sorry, get

0:44:57.520 --> 0:45:00.880
<v Speaker 1>all those units mixed up. So my question, and probably

0:45:00.920 --> 0:45:03.800
<v Speaker 1>everyone's question at this point, and Shane, why we brought

0:45:03.960 --> 0:45:08.879
<v Speaker 1>you here, is why on Earth, with something as adorable

0:45:09.239 --> 0:45:14.200
<v Speaker 1>as a puffer fish need to make such a potent toxin?

0:45:14.320 --> 0:45:17.000
<v Speaker 1>Do they just want to kill us? Do pufferfish hate us?

0:45:17.200 --> 0:45:19.480
<v Speaker 1>Why tell me? Why? Please?

0:45:20.480 --> 0:45:46.360
<v Speaker 3>That is a phenomenal question. So pufferfish. They did not,

0:45:47.040 --> 0:45:49.759
<v Speaker 3>you know, they weren't the first to invent to toe

0:45:49.760 --> 0:45:53.600
<v Speaker 3>to toxin, but Totota toxin is actually named after them,

0:45:53.760 --> 0:45:57.680
<v Speaker 3>well kind of. Totota toxin is actually named after an

0:45:57.880 --> 0:46:04.719
<v Speaker 3>order of bony fish called tetra Odontiformes, which includes the

0:46:04.760 --> 0:46:08.560
<v Speaker 3>puffer fish, but also porcupine fish and you know, the

0:46:08.560 --> 0:46:11.359
<v Speaker 3>big floppy ocean sunfish and they're like huge and kind

0:46:11.360 --> 0:46:14.160
<v Speaker 3>of flat and really goofy looking, and also triggerfish. So

0:46:14.160 --> 0:46:17.280
<v Speaker 3>all together it's about almost three hundred and fifty species

0:46:17.320 --> 0:46:20.440
<v Speaker 3>in the order, but not all of these species have

0:46:20.520 --> 0:46:23.000
<v Speaker 3>to trot to toxin, you know. So it was named

0:46:23.080 --> 0:46:27.360
<v Speaker 3>in nineteen ten actually as the principal toxin in puffer

0:46:27.400 --> 0:46:30.879
<v Speaker 3>fish and obviously the principal component of fugu as were

0:46:31.120 --> 0:46:33.399
<v Speaker 3>as you were saying before, you know, Since then, it's

0:46:33.400 --> 0:46:38.719
<v Speaker 3>been subsequently described in a really wide array of organisms

0:46:38.719 --> 0:46:41.080
<v Speaker 3>across the tree of life, sort of both marine and

0:46:41.640 --> 0:46:46.560
<v Speaker 3>terrestrial organisms. So several obviously several genera which is the

0:46:46.600 --> 0:46:51.440
<v Speaker 3>plural of genus, several genera of puffer fish habit specifically

0:46:51.440 --> 0:46:55.120
<v Speaker 3>in like liver and gonads. The marine gobi, which is

0:46:55.120 --> 0:46:58.319
<v Speaker 3>another bony fish, has to trot to toxin in its

0:46:58.320 --> 0:47:01.759
<v Speaker 3>skin and muscles. And then even there are several invertebrates,

0:47:01.760 --> 0:47:04.880
<v Speaker 3>marine invertebrates that also have it. So there are several

0:47:04.960 --> 0:47:09.640
<v Speaker 3>species of marine flatworms. There is a trumpet shellfish, which

0:47:09.680 --> 0:47:12.760
<v Speaker 3>is a different invertebrate that has it in a digestive gland.

0:47:13.360 --> 0:47:17.879
<v Speaker 3>Horseshoe crabs apparently have them in their eggs. Some starfish species,

0:47:18.200 --> 0:47:20.360
<v Speaker 3>I should say, one of the I think most interesting

0:47:20.440 --> 0:47:22.880
<v Speaker 3>is actually the blue ringed octopus that actually has it

0:47:23.400 --> 0:47:26.480
<v Speaker 3>in its salivary glands and it uses it as I

0:47:26.760 --> 0:47:29.279
<v Speaker 3>you know, as it's co opted as a venom in

0:47:29.719 --> 0:47:32.360
<v Speaker 3>that species. So that's that's really interesting.

0:47:32.400 --> 0:47:36.360
<v Speaker 1>The coolest love blue ring octopus. They're like take this.

0:47:36.600 --> 0:47:38.879
<v Speaker 1>They're so small and they're like you want to fight

0:47:38.920 --> 0:47:41.080
<v Speaker 1>with me, and then they bite you and then you die.

0:47:41.280 --> 0:47:43.880
<v Speaker 2>Oh my god, I love them.

0:47:44.920 --> 0:47:47.360
<v Speaker 3>That's the first, the first time I've ever heard it

0:47:47.400 --> 0:47:50.000
<v Speaker 3>bites you and it dies. Oh my god. I love them.

0:47:50.160 --> 0:47:53.240
<v Speaker 3>That you hear that very often except on this podcast.

0:47:54.360 --> 0:47:58.800
<v Speaker 2>I have a quick question, Shane. So, okay, you mentioned

0:47:58.880 --> 0:48:02.240
<v Speaker 2>that the organ of a lot of where this tatorta

0:48:02.280 --> 0:48:05.399
<v Speaker 2>toxin is stored for a lot of these animals. Why

0:48:05.760 --> 0:48:11.480
<v Speaker 2>the liver, the gonads, the intestinal, whatever system. Why why there?

0:48:12.160 --> 0:48:16.480
<v Speaker 3>So that is a great question, and quite frankly, I

0:48:16.480 --> 0:48:20.040
<v Speaker 3>don't think we know there's so in doing research for this,

0:48:20.160 --> 0:48:22.640
<v Speaker 3>I realized that there's there's a ton that we don't

0:48:22.719 --> 0:48:26.399
<v Speaker 3>know about tatro to toxin. Yeah, in terms of how

0:48:26.440 --> 0:48:30.319
<v Speaker 3>it contributes to to biodiversity and how the vast array

0:48:30.360 --> 0:48:32.680
<v Speaker 3>of organisms that use it, how they actually go about

0:48:32.719 --> 0:48:33.120
<v Speaker 3>using it.

0:48:33.200 --> 0:48:35.880
<v Speaker 1>Yeah. Yeah, that's so cool.

0:48:36.200 --> 0:48:39.760
<v Speaker 3>Yeah, it's it's weird. It is very weird because I mean, essentially,

0:48:39.840 --> 0:48:43.839
<v Speaker 3>like you're talking about chemical warfare essentially, right, I mean

0:48:44.239 --> 0:48:48.120
<v Speaker 3>you're taking this super super toxic substance and integrating it

0:48:48.200 --> 0:48:51.319
<v Speaker 3>into your body in some form or fashion and then

0:48:51.440 --> 0:48:53.400
<v Speaker 3>using that as as a defense.

0:48:53.760 --> 0:48:54.400
<v Speaker 1>Yeah.

0:48:54.440 --> 0:48:57.719
<v Speaker 3>So, not only does it occur in marine organisms, but

0:48:57.719 --> 0:49:00.440
<v Speaker 3>they're also terrestrial species. You know, species that live on

0:49:00.520 --> 0:49:03.640
<v Speaker 3>land that use it. And this is the amphibians. Uh So,

0:49:04.360 --> 0:49:06.960
<v Speaker 3>you know, there are tree frog species in the genus

0:49:07.000 --> 0:49:10.839
<v Speaker 3>Ata Lopus that use Totrota toxin. And then it's been

0:49:10.920 --> 0:49:15.480
<v Speaker 3>most commonly studied in newts, So newts what are called

0:49:15.560 --> 0:49:19.160
<v Speaker 3>rough skin newts. They're in the genus Tarika. Uh So

0:49:19.200 --> 0:49:22.360
<v Speaker 3>they have really large volumes of to torot to toxin

0:49:22.840 --> 0:49:26.239
<v Speaker 3>in their skin and actually also five different genera that

0:49:26.400 --> 0:49:28.400
<v Speaker 3>of salamander that that have to tota toxin.

0:49:28.600 --> 0:49:30.960
<v Speaker 1>What this is?

0:49:31.400 --> 0:49:31.720
<v Speaker 5>Why?

0:49:32.520 --> 0:49:35.080
<v Speaker 1>Yeah? Just tell us why? Shame? We need to know

0:49:35.160 --> 0:49:36.120
<v Speaker 1>what's the deal here?

0:49:36.239 --> 0:49:41.759
<v Speaker 3>Bro Okay, Well, so if I can, before I get

0:49:41.800 --> 0:49:43.839
<v Speaker 3>to the why, the question is how?

0:49:44.160 --> 0:49:47.160
<v Speaker 1>Yeah, okay, good question is that?

0:49:47.200 --> 0:49:53.120
<v Speaker 3>Okay? Okay? So just to give you give you sort

0:49:53.160 --> 0:49:55.920
<v Speaker 3>of the scale of this. We're talking about hundreds of

0:49:56.120 --> 0:50:00.480
<v Speaker 3>millions of years of diversity of life. So if we're

0:50:00.480 --> 0:50:03.520
<v Speaker 3>talking about across the tree of life between you know,

0:50:03.680 --> 0:50:08.000
<v Speaker 3>worms and and you know other invertebrates and terrestrial organisms,

0:50:08.120 --> 0:50:11.120
<v Speaker 3>terrestrial vertebrates and fish, we're talking about hundreds of millions

0:50:11.160 --> 0:50:13.920
<v Speaker 3>of years of diversity. And you get these species popping

0:50:13.960 --> 0:50:17.840
<v Speaker 3>up across the tree of life that all are using

0:50:17.880 --> 0:50:20.560
<v Speaker 3>this chemical warfare like co opting to trot to toxin

0:50:20.960 --> 0:50:24.759
<v Speaker 3>to use as as typically as defense. Right. So, there

0:50:24.760 --> 0:50:27.600
<v Speaker 3>are actually two major hypotheses about where totrot to toxin

0:50:27.680 --> 0:50:31.799
<v Speaker 3>comes from. So one is an indogenous origin, right, So

0:50:31.840 --> 0:50:34.840
<v Speaker 3>something that is you know, genetically coded in an animal

0:50:34.920 --> 0:50:38.120
<v Speaker 3>to produce totrot to toxin. And there is some support

0:50:38.200 --> 0:50:41.640
<v Speaker 3>for this and that typically comes from from the tree frogs.

0:50:41.880 --> 0:50:44.640
<v Speaker 3>I mentioned that in that genus Ata loopus, where if

0:50:44.680 --> 0:50:48.239
<v Speaker 3>you take those tree frog species and you bring them

0:50:48.360 --> 0:50:51.239
<v Speaker 3>into like a controlled environment where you control what you

0:50:51.880 --> 0:50:55.560
<v Speaker 3>feed them, what they're in contact with, even years after that,

0:50:55.840 --> 0:50:59.680
<v Speaker 3>they can maintain really high levels of toxicity. And even

0:50:59.719 --> 0:51:02.640
<v Speaker 3>frog that are hatched in the lab still have amounts

0:51:02.800 --> 0:51:05.240
<v Speaker 3>like measurable amounts of to torota toxin in their skin,

0:51:05.560 --> 0:51:09.080
<v Speaker 3>which suggests that they're actually producing it somehow. WHOA, but

0:51:09.840 --> 0:51:14.640
<v Speaker 3>what yeah exactly I And again I don't really think

0:51:14.680 --> 0:51:18.239
<v Speaker 3>we know how this works yet, Yeah, which is really

0:51:18.239 --> 0:51:22.560
<v Speaker 3>surprising actually. But then the second hypothesis is actually in

0:51:23.200 --> 0:51:26.840
<v Speaker 3>exogenous origin, so that animals are uptaking to trot to

0:51:26.840 --> 0:51:31.439
<v Speaker 3>toxin either through the food chain or through symbioses, and

0:51:31.840 --> 0:51:34.680
<v Speaker 3>a lot of evidence for this. It actually comes from

0:51:34.680 --> 0:51:38.839
<v Speaker 3>the puffer fish. So people captively breed puffer fish for

0:51:39.040 --> 0:51:42.160
<v Speaker 3>food and also for the pet trade, and pufferfish that

0:51:42.200 --> 0:51:44.640
<v Speaker 3>are born in captivity are actually not toxic. They don't

0:51:44.680 --> 0:51:47.480
<v Speaker 3>have any measurable amounts of to trot to toxin. But

0:51:48.320 --> 0:51:50.480
<v Speaker 3>if you feed them to trot to toxin, they very

0:51:50.560 --> 0:51:51.920
<v Speaker 3>quickly become toxic.

0:51:52.840 --> 0:51:57.800
<v Speaker 2>Wait, so is it possible that there are distinct groups

0:51:57.960 --> 0:52:03.560
<v Speaker 2>of animals that some can produce some some it's indogenous

0:52:03.560 --> 0:52:05.120
<v Speaker 2>and for some it's exogenous.

0:52:06.400 --> 0:52:07.960
<v Speaker 3>Yes, exactly.

0:52:08.160 --> 0:52:12.400
<v Speaker 1>A face is so excited right now, she's just like

0:52:12.400 --> 0:52:17.600
<v Speaker 1>like her eyes can't contain. That's amazing, it's amazing.

0:52:17.360 --> 0:52:20.520
<v Speaker 3>And it's it's this really sort of wild example of

0:52:20.560 --> 0:52:25.759
<v Speaker 3>this classic question and evolutionary biology of the repeatability. Right

0:52:25.840 --> 0:52:28.160
<v Speaker 3>if like, you know, if you get the same results,

0:52:28.520 --> 0:52:31.040
<v Speaker 3>i e. I have to toto toxin, don't eat me

0:52:31.120 --> 0:52:33.399
<v Speaker 3>or I'll mess you up, do you get there by

0:52:33.440 --> 0:52:35.320
<v Speaker 3>the same by the same path?

0:52:35.800 --> 0:52:35.920
<v Speaker 5>Right?

0:52:35.920 --> 0:52:38.680
<v Speaker 3>And it seems like, at least in this case, the

0:52:38.760 --> 0:52:41.719
<v Speaker 3>answer is there are several paths to potentially get there,

0:52:41.760 --> 0:52:45.200
<v Speaker 3>either through producing it or through uptaking it in the

0:52:45.560 --> 0:52:48.600
<v Speaker 3>in the environment, or you know, which I think is

0:52:48.600 --> 0:52:53.279
<v Speaker 3>an even cooler potential explanation is through symbioses. You know,

0:52:53.320 --> 0:52:57.000
<v Speaker 3>A major a major hypothesis is that a lot of

0:52:57.040 --> 0:53:00.160
<v Speaker 3>these species that have to trototoxin have them because as

0:53:00.160 --> 0:53:04.080
<v Speaker 3>they formed a symbiotic relationship with bacteria that produced the

0:53:04.120 --> 0:53:09.240
<v Speaker 3>toatrot to toxin, so like Vibrio bacteria is most often

0:53:09.920 --> 0:53:13.319
<v Speaker 3>suggested as the you know, the symbio in this case,

0:53:13.320 --> 0:53:18.480
<v Speaker 3>but also pseudomonous and Actinomycetes M. Yeah. But in either case, right,

0:53:18.480 --> 0:53:23.440
<v Speaker 3>there remains this really important question about the repeatability of evolution. Right, So,

0:53:23.480 --> 0:53:28.359
<v Speaker 3>either you have independent origins of totrototoxin production right via

0:53:28.440 --> 0:53:32.279
<v Speaker 3>these indogenous means, or even if you're uptaking it from

0:53:32.320 --> 0:53:36.000
<v Speaker 3>the environment, you still have to biologically incorporate it into

0:53:36.040 --> 0:53:39.160
<v Speaker 3>your own body without being affected by it, right, so

0:53:39.200 --> 0:53:41.319
<v Speaker 3>you still have to have some level of resistance.

0:53:41.480 --> 0:53:43.000
<v Speaker 2>What is this is insane?

0:53:43.080 --> 0:53:46.920
<v Speaker 1>It's not like pufferfish don't have their own sodium channels, right.

0:53:46.880 --> 0:53:47.359
<v Speaker 2>They do?

0:53:47.880 --> 0:53:50.520
<v Speaker 5>Right, Like what.

0:53:49.520 --> 0:53:52.239
<v Speaker 1>What you can feed them to trotoxin are like, no

0:53:52.280 --> 0:53:53.759
<v Speaker 1>worry about and live will take care of.

0:53:53.719 --> 0:53:55.560
<v Speaker 3>This, my lip exactly.

0:53:56.640 --> 0:53:58.680
<v Speaker 1>I just skipped the other half of the word that

0:53:58.840 --> 0:53:59.719
<v Speaker 1>wasn't intentional.

0:54:00.800 --> 0:54:02.359
<v Speaker 3>My lip Tot's got this, bro.

0:54:04.120 --> 0:54:04.799
<v Speaker 1>Exactly.

0:54:05.719 --> 0:54:08.319
<v Speaker 3>Yeah. So and this obviously like brings us to your

0:54:08.360 --> 0:54:13.080
<v Speaker 3>initial question, which is why. And you know, as I described,

0:54:13.160 --> 0:54:17.719
<v Speaker 3>most of these species are incorporating it in their organs,

0:54:18.880 --> 0:54:22.600
<v Speaker 3>and it seems that this is mostly associated with defense

0:54:22.800 --> 0:54:25.440
<v Speaker 3>against predation. Right, So there are a lot of species

0:54:25.719 --> 0:54:28.080
<v Speaker 3>that incorporated in different organs, but a lot also have

0:54:28.200 --> 0:54:30.399
<v Speaker 3>it in their skin and in their muscle, right, so

0:54:30.600 --> 0:54:33.319
<v Speaker 3>if you bit them or tried to hold on to them,

0:54:33.680 --> 0:54:35.200
<v Speaker 3>you know, obviously if you know, if you're biding them,

0:54:35.239 --> 0:54:37.279
<v Speaker 3>you're biding them with your mouth, which leads to, you know,

0:54:37.320 --> 0:54:38.840
<v Speaker 3>a lot of the issues that you were just talking

0:54:39.239 --> 0:54:41.200
<v Speaker 3>that we were just talking about when it comes to

0:54:41.880 --> 0:54:45.120
<v Speaker 3>human infection with toratroda toxin, so it seems to be

0:54:45.160 --> 0:54:50.040
<v Speaker 3>associated by and large with defense against predation, which also

0:54:50.120 --> 0:54:52.840
<v Speaker 3>sort of brings us to this weird dynamic that comes

0:54:52.880 --> 0:54:56.760
<v Speaker 3>out of these praise species having to trot to toxin,

0:54:56.840 --> 0:55:00.239
<v Speaker 3>which are what we call evolutionary arms races. Right, So,

0:55:01.000 --> 0:55:04.799
<v Speaker 3>if you're a puffer fish or if you're a rough

0:55:04.840 --> 0:55:07.719
<v Speaker 3>skin newt swimming around or walking around doing your thing,

0:55:08.120 --> 0:55:10.920
<v Speaker 3>you don't want to be eaten. That's generally an unpleasant

0:55:10.920 --> 0:55:13.879
<v Speaker 3>experience that we all try to avoid. But if you're

0:55:13.880 --> 0:55:17.200
<v Speaker 3>a predator, typically you like to eat things, and this

0:55:17.400 --> 0:55:22.080
<v Speaker 3>like sort of very simple dynamic to competing factors, you know,

0:55:22.200 --> 0:55:25.279
<v Speaker 3>lead to evolutionary arms races where things that don't want

0:55:25.320 --> 0:55:28.000
<v Speaker 3>to get eaten figure out ways to not get eaten,

0:55:28.080 --> 0:55:30.840
<v Speaker 3>either by running really fast or growing large or growing

0:55:30.880 --> 0:55:34.279
<v Speaker 3>hard parts that can't be chewed on. But then predators,

0:55:34.719 --> 0:55:37.960
<v Speaker 3>you know, they find ways to get around that. And

0:55:38.000 --> 0:55:41.880
<v Speaker 3>there's a really interesting case when it comes to trototoxins,

0:55:42.400 --> 0:55:45.200
<v Speaker 3>particularly in these rough skin newts that I mentioned before.

0:55:45.360 --> 0:55:49.400
<v Speaker 3>So this species ranges across the west coast of the

0:55:49.520 --> 0:55:52.200
<v Speaker 3>United States all the way from like southern Canada down

0:55:52.239 --> 0:55:56.359
<v Speaker 3>through southern California, and across the range, they vary in

0:55:56.400 --> 0:56:00.879
<v Speaker 3>their toxicity. So some populations are very highly toxic and

0:56:00.920 --> 0:56:06.040
<v Speaker 3>some are only mildly toxic. And across their range they

0:56:06.080 --> 0:56:08.680
<v Speaker 3>are also garter snakes like very calmon. I'm sure we've

0:56:08.680 --> 0:56:12.400
<v Speaker 3>all seen garter snakes outside racing from place to place,

0:56:12.760 --> 0:56:17.480
<v Speaker 3>and garter snakes they occur across the same region, and

0:56:17.800 --> 0:56:21.839
<v Speaker 3>they're the only predator of the newt that is known

0:56:21.880 --> 0:56:25.680
<v Speaker 3>to be resistant to totro to toxin. What so they

0:56:26.200 --> 0:56:29.239
<v Speaker 3>I know, right, right, So these the snakes they eat

0:56:29.320 --> 0:56:32.480
<v Speaker 3>newts regularly, right, and this has led to a matched

0:56:32.600 --> 0:56:36.800
<v Speaker 3>resistance to tatrot to toxin. And so where the newts

0:56:36.840 --> 0:56:41.080
<v Speaker 3>are more toxic, the snakes are more resistant to to toxic. Good,

0:56:44.520 --> 0:56:47.000
<v Speaker 3>I know. And so just to give you an idea,

0:56:47.120 --> 0:56:53.719
<v Speaker 3>this ranges by three orders of magnitude. What so we're

0:56:53.760 --> 0:56:57.760
<v Speaker 3>talking about some snakes are one thousand times more resistant

0:56:57.760 --> 0:56:59.320
<v Speaker 3>to toatrot to toxin than others.

0:57:01.360 --> 0:57:05.200
<v Speaker 1>What that is so cool?

0:57:05.680 --> 0:57:07.840
<v Speaker 3>I know, which brings us back to this idea of

0:57:07.920 --> 0:57:11.840
<v Speaker 3>the repeatability because this resistance, it seems to have evolved

0:57:11.880 --> 0:57:16.200
<v Speaker 3>independently at least twice within garter snakes, so separate lineages

0:57:16.240 --> 0:57:19.040
<v Speaker 3>have come up with this solution to being able to

0:57:19.080 --> 0:57:21.240
<v Speaker 3>eat these ruskin nuts. It's wild.

0:57:21.640 --> 0:57:26.640
<v Speaker 1>It's like different garter snakes the same. It's like garter snakes.

0:57:26.680 --> 0:57:28.800
<v Speaker 1>You think those are the same snake, but there's different

0:57:28.800 --> 0:57:31.680
<v Speaker 1>populations that have evolved this different times.

0:57:31.760 --> 0:57:35.680
<v Speaker 2>And clearly these newts are really important food source.

0:57:35.960 --> 0:57:39.040
<v Speaker 3>Yeah, I mean, and it must be extremely important, right

0:57:39.080 --> 0:57:41.880
<v Speaker 3>because you know this fundamental question idea is like, well,

0:57:41.920 --> 0:57:45.120
<v Speaker 3>how how do you get this resistance? Well, you know

0:57:45.160 --> 0:57:47.960
<v Speaker 3>you've said you know how to torta talksin affects your

0:57:48.200 --> 0:57:52.320
<v Speaker 3>your sodium channels. But these snakes actually have mutations in

0:57:52.360 --> 0:57:57.000
<v Speaker 3>their sodium channels that make to tota talksin less efficient

0:57:57.080 --> 0:57:58.160
<v Speaker 3>at binding to them.

0:57:58.480 --> 0:58:01.920
<v Speaker 1>So cool. What I said there was different kinds of

0:58:01.960 --> 0:58:04.480
<v Speaker 1>sodium channels. Man, They're just like, we're gonna skip to

0:58:04.600 --> 0:58:07.680
<v Speaker 1>all the resisting kind and just forget about this, these

0:58:07.720 --> 0:58:08.600
<v Speaker 1>ones over here.

0:58:09.480 --> 0:58:12.040
<v Speaker 2>That is, so, why don't we all have resistance sodium

0:58:12.120 --> 0:58:15.240
<v Speaker 2>channels because we're not.

0:58:15.400 --> 0:58:20.520
<v Speaker 3>All because our species haven't been Yeah yeah, exactly, yeah yeah.

0:58:20.600 --> 0:58:22.560
<v Speaker 3>But it does come out of it does come out

0:58:22.560 --> 0:58:25.400
<v Speaker 3>a trade off, right, I mean, as you know obviously

0:58:25.640 --> 0:58:28.640
<v Speaker 3>you know these sodium channels, they provide a really basic

0:58:28.960 --> 0:58:32.640
<v Speaker 3>biological function, right, and they help us to you know,

0:58:32.720 --> 0:58:36.120
<v Speaker 3>to contract our muscles and move around. And snakes that

0:58:36.280 --> 0:58:40.520
<v Speaker 3>have very high to tototoxin resistance cannot move as quickly

0:58:40.800 --> 0:58:41.720
<v Speaker 3>as those that don't.

0:58:41.880 --> 0:58:47.240
<v Speaker 2>Interesting, weird, huh. So there's like a substantial tradeoff.

0:58:47.800 --> 0:58:51.120
<v Speaker 3>Yes, absolutely, but it would be really cool if that

0:58:51.160 --> 0:58:55.600
<v Speaker 3>was the whole story, right. But recently, actually, just earlier

0:58:55.680 --> 0:58:58.880
<v Speaker 3>this year, in twenty eighteen, there was a study again

0:58:59.000 --> 0:59:04.640
<v Speaker 3>in two species of skinned newts that suggest that they

0:59:04.720 --> 0:59:09.480
<v Speaker 3>showed that individuals that were more toxic also had fewer

0:59:09.680 --> 0:59:12.400
<v Speaker 3>parasites than less toxic individuals.

0:59:13.880 --> 0:59:16.000
<v Speaker 1>We just both got so excited.

0:59:16.960 --> 0:59:18.400
<v Speaker 3>I thought you would like that one.

0:59:19.560 --> 0:59:21.600
<v Speaker 2>One more time, just for emphasis.

0:59:21.600 --> 0:59:24.160
<v Speaker 1>Please say it again, please, So.

0:59:24.720 --> 0:59:30.720
<v Speaker 3>Rough skin neuts that are more toxic have fewer parasites

0:59:30.920 --> 0:59:32.600
<v Speaker 3>than they're less toxic counterparts.

0:59:32.680 --> 0:59:33.760
<v Speaker 1>My god.

0:59:34.280 --> 0:59:38.120
<v Speaker 3>Yeah, So it seems like they're actually there's the possibility

0:59:38.160 --> 0:59:41.560
<v Speaker 3>that not only does it help them in defense against predators,

0:59:41.920 --> 0:59:45.080
<v Speaker 3>but it may also help them defend against infection.

0:59:45.760 --> 0:59:51.040
<v Speaker 2>Amazing. What kind of so parasites meaning like ectoparasites or

0:59:51.560 --> 0:59:54.600
<v Speaker 2>are we also talking like bacteria, viruses, et cetera.

0:59:55.320 --> 0:59:58.240
<v Speaker 3>So, if I remember correctly, they looked mostly at sort

0:59:58.240 --> 1:00:01.560
<v Speaker 3>of larger parasites, so things like parasitic worms, and even

1:00:01.720 --> 1:00:04.760
<v Speaker 3>they looked at fungi as well, like parasitic fungi for

1:00:05.000 --> 1:00:08.240
<v Speaker 3>you know that effect newts, things like cattrid fungus for instand.

1:00:08.280 --> 1:00:12.240
<v Speaker 1>Oh oh oh, that's going to probably have to be

1:00:12.320 --> 1:00:13.240
<v Speaker 1>a whole own episode.

1:00:13.280 --> 1:00:15.120
<v Speaker 2>Oh yeah, for sure, that's.

1:00:15.520 --> 1:00:17.080
<v Speaker 3>Won't dive too deep into that one.

1:00:18.360 --> 1:00:19.400
<v Speaker 1>That's amazing.

1:00:20.000 --> 1:00:23.480
<v Speaker 3>Yeah, And so this brings me back to this original

1:00:23.600 --> 1:00:27.480
<v Speaker 3>question Aaron Welsh, that you pose of like why like

1:00:27.520 --> 1:00:29.280
<v Speaker 3>why do we care, like, you know, why do we

1:00:29.320 --> 1:00:32.880
<v Speaker 3>want to get into like the mechanisms of all this stuff?

1:00:32.920 --> 1:00:35.400
<v Speaker 3>I mean, obviously hearing these stories, it's it's actually it's

1:00:35.480 --> 1:00:38.960
<v Speaker 3>really cool, you know, just on its own, but there

1:00:39.080 --> 1:00:42.400
<v Speaker 3>is I think some utility and really trying to understand

1:00:42.400 --> 1:00:45.000
<v Speaker 3>the mechanisms either, you know, when it comes to zombie powder,

1:00:45.080 --> 1:00:47.520
<v Speaker 3>or when it comes to you know, these crazy creatures

1:00:47.520 --> 1:00:50.560
<v Speaker 3>across the tree of life that are using totort to toxin,

1:00:50.600 --> 1:00:53.800
<v Speaker 3>there is some inherent utility there, you know, when it

1:00:53.800 --> 1:00:57.160
<v Speaker 3>comes to our understanding of basic biology and medicine. So

1:00:57.800 --> 1:00:59.960
<v Speaker 3>back in I think it was like nineteen twenty nine

1:01:00.080 --> 1:01:03.840
<v Speaker 3>and there's this guy, August Crowe, you know, he has

1:01:03.880 --> 1:01:06.200
<v Speaker 3>this what became a pretty famous quote, and he said

1:01:06.200 --> 1:01:10.120
<v Speaker 3>that for some large number of human related problems, there

1:01:10.160 --> 1:01:14.200
<v Speaker 3>will be some animal of choice for which that problem

1:01:14.240 --> 1:01:17.360
<v Speaker 3>can be most conveniently studied, right, And this is you know,

1:01:17.440 --> 1:01:20.480
<v Speaker 3>this became his principle, and that's based on this sort

1:01:20.480 --> 1:01:24.680
<v Speaker 3>of fundamental observation that evolution by natural selection has produced

1:01:24.720 --> 1:01:28.480
<v Speaker 3>a vast array of diversity and form and function. And

1:01:28.520 --> 1:01:30.840
<v Speaker 3>because of this, some species are really well suited for

1:01:30.960 --> 1:01:35.960
<v Speaker 3>understanding human related problems, right because they've evolved extreme characteristics

1:01:35.680 --> 1:01:39.000
<v Speaker 3>that mimic human disease states, or they allow us to

1:01:39.000 --> 1:01:42.680
<v Speaker 3>conduct experiments that would be otherwise impossible, and this gives

1:01:42.760 --> 1:01:45.840
<v Speaker 3>us fundamental insights into the diseases that plague us and

1:01:45.880 --> 1:01:49.800
<v Speaker 3>help us to design effective treatments for those diseases. So

1:01:49.840 --> 1:01:52.960
<v Speaker 3>in the case of totroto toxin resistance right in these species.

1:01:53.560 --> 1:01:57.280
<v Speaker 3>Understanding how their ion channels allow them to live with

1:01:57.320 --> 1:02:01.800
<v Speaker 3>tatrota toxin may provide really valuable insights into many diseases

1:02:01.840 --> 1:02:05.560
<v Speaker 3>that are thought to result from ion channel dysfunction. And

1:02:05.600 --> 1:02:08.880
<v Speaker 3>this includes, you know, things from like color blindness and

1:02:09.000 --> 1:02:15.040
<v Speaker 3>night blindness, to cystic fibrosis to Alzheimer's to Parkinson's to schizophrenia.

1:02:15.400 --> 1:02:18.920
<v Speaker 3>You know, so they potentially provide some really fundamental insights

1:02:18.920 --> 1:02:23.320
<v Speaker 3>into understanding how you know, these really basic aspects of

1:02:23.360 --> 1:02:25.959
<v Speaker 3>biology can be modified and improved upon.

1:02:27.240 --> 1:02:28.440
<v Speaker 1>That was so gorgeous.

1:02:28.480 --> 1:02:31.840
<v Speaker 2>It was so perfectly put and fascinating, and we were

1:02:31.880 --> 1:02:35.640
<v Speaker 2>both at the same time form our hands.

1:02:35.480 --> 1:02:37.600
<v Speaker 1>And we were putting them to the computers.

1:02:37.640 --> 1:02:40.920
<v Speaker 2>We were like, oh my god, you guys, stop that. No,

1:02:41.200 --> 1:02:44.680
<v Speaker 2>but that is Oh that was just really well set

1:02:44.720 --> 1:02:47.320
<v Speaker 2>and really well put. And I think that you made

1:02:47.360 --> 1:02:49.000
<v Speaker 2>a really good point that it's not just driven by

1:02:49.040 --> 1:02:53.160
<v Speaker 2>this curiosity, but there is a function and a season,

1:02:53.280 --> 1:02:56.960
<v Speaker 2>an application for doing this type of research and for

1:02:57.720 --> 1:03:00.840
<v Speaker 2>being even just interested in it and learning about it

1:03:01.200 --> 1:03:04.880
<v Speaker 2>from a comparative angle or from a historical angle or

1:03:04.920 --> 1:03:07.440
<v Speaker 2>from a medical angle, Like there's a reason the Angle.

1:03:07.720 --> 1:03:16.640
<v Speaker 1>Yeah, oh cool, I know it's science dude. That was great.

1:03:16.960 --> 1:03:20.480
<v Speaker 2>That was a great episode. So should we do sources?

1:03:20.520 --> 1:03:22.200
<v Speaker 1>Probably? Okay?

1:03:22.840 --> 1:03:26.000
<v Speaker 2>Uh So I read a few books or sections of books.

1:03:26.560 --> 1:03:30.160
<v Speaker 2>I would recommend Invisible Powers, which is edited by Claudine

1:03:30.240 --> 1:03:36.160
<v Speaker 2>Michelle and Patrick Bellgarde Smith, and also Passage of Darkness

1:03:36.200 --> 1:03:41.480
<v Speaker 2>by Wade Davis, American Zombie Gothic by Kyle William Bishop,

1:03:41.520 --> 1:03:45.240
<v Speaker 2>which kind of details the transformation of the evolution of

1:03:45.280 --> 1:03:49.880
<v Speaker 2>the zombie genre in movies. Cosanba or the Congress of

1:03:49.920 --> 1:03:53.560
<v Speaker 2>Santa Barbara to which is like a place to learn

1:03:53.600 --> 1:04:02.640
<v Speaker 2>about and to have scholarship on vodo. I don't have

1:04:03.120 --> 1:04:04.080
<v Speaker 2>we'll post all of these.

1:04:04.160 --> 1:04:06.400
<v Speaker 1>Yeah, that's the thing is minor, always way too long.

1:04:06.440 --> 1:04:09.160
<v Speaker 1>I have a bunch of articles that were cool, but

1:04:09.320 --> 1:04:11.200
<v Speaker 1>you can find them on our website This podcast will

1:04:11.280 --> 1:04:13.720
<v Speaker 1>Kill You dot com. We have every single one of

1:04:13.760 --> 1:04:18.080
<v Speaker 1>our episodes. We have all of our sources listed there. So, Shane,

1:04:18.120 --> 1:04:19.640
<v Speaker 1>do you have any things you'd like to shout out

1:04:19.640 --> 1:04:21.000
<v Speaker 1>beside your brain? Oh?

1:04:21.040 --> 1:04:23.440
<v Speaker 3>I guess what I will shout out is the last

1:04:23.760 --> 1:04:28.760
<v Speaker 3>paper I mentioned about poisons and parasites in Newts was

1:04:28.760 --> 1:04:31.600
<v Speaker 3>published earlier this year in the Journal of Animal Ecology.

1:04:32.400 --> 1:04:35.240
<v Speaker 3>The lead author's last name is Johnson. Johnson at all

1:04:35.720 --> 1:04:36.760
<v Speaker 3>twenty eighteen.

1:04:36.920 --> 1:04:41.200
<v Speaker 1>Sweet. That's right cool. Also, Shane, tell us where everyone

1:04:41.240 --> 1:04:44.800
<v Speaker 1>can find you and stalk you and listen to your podcast.

1:04:45.280 --> 1:04:49.400
<v Speaker 3>Yeah, so you can find me at s Campbell Stayton

1:04:49.880 --> 1:04:54.320
<v Speaker 3>on Twitter. You can also hit up at Superbio podcast

1:04:54.520 --> 1:04:55.680
<v Speaker 3>to check out new episodes.

1:04:56.080 --> 1:04:58.600
<v Speaker 2>Shane, thank you so much for joining us.

1:04:58.680 --> 1:05:00.560
<v Speaker 1>Yes, it is awesome for fun.

1:05:01.400 --> 1:05:03.520
<v Speaker 3>I had a great time. Thank you guys so much, and.

1:05:03.480 --> 1:05:06.200
<v Speaker 1>Thank you everybody for listening. We love you. You're the

1:05:06.280 --> 1:05:07.360
<v Speaker 1>number one greatest.

1:05:08.000 --> 1:05:11.120
<v Speaker 2>Thanks to Bloodmobile for providing all of our music.

1:05:11.240 --> 1:05:16.479
<v Speaker 1>We love you so much. And yeah, join us next

1:05:16.480 --> 1:05:18.120
<v Speaker 1>time for something else.

1:05:18.240 --> 1:05:23.800
<v Speaker 2>Creepy Now, guess what wash your zombified hands?

1:05:23.960 --> 1:05:24.960
<v Speaker 1>Yep, you're filthy.

1:05:25.240 --> 1:05:49.560
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