WEBVTT - SYSK Selects: Fecal Transplants: You Gonna Drink That Poop? 0:00:01.760 --> 0:00:04.960 Hello, Stuff you Should Know listeners, Welcome to the Saturday 0:00:05.000 --> 0:00:09.119 Selects Chuck edition. Uh. This week, I'm going with one 0:00:09.200 --> 0:00:17.240 from January entitled Fecal Transplants Colin, You're gonna drink that poop? Uh. 0:00:17.360 --> 0:00:21.239 This one came up recently and I can't remember exactly 0:00:21.239 --> 0:00:23.279 why my real life. Oh I know why because I 0:00:23.320 --> 0:00:28.520 was watching the Great Tig Nataro show One Mississippi UM, 0:00:28.520 --> 0:00:30.920 which has a second season that's starting kind of right 0:00:30.960 --> 0:00:33.760 about now, and on that show, I think she had 0:00:33.800 --> 0:00:37.280 a fecal transplant, and I think she did in real life, 0:00:37.479 --> 0:00:39.720 so it made me think of this one. It's just 0:00:39.760 --> 0:00:42.720 being a really interesting kind of um. Despite the fact 0:00:42.720 --> 0:00:48.320 that their poop shakes cutting edge medical uh technology, I 0:00:48.320 --> 0:00:51.040 guess you would call it, or at least procedures and 0:00:51.159 --> 0:00:54.200 um and a serious note it it really helps people 0:00:54.200 --> 0:00:57.040 out who have real problems. So UM. We do make 0:00:57.080 --> 0:00:59.560 quite a few jokes, but it was pretty cool show, 0:00:59.680 --> 0:01:01.360 So give it a listen to. I hope you enjoy it. 0:01:09.720 --> 0:01:12.880 Welcome to you Stuff you Should Know from House Stuff 0:01:12.920 --> 0:01:21.400 Works dot com. Hey, and welcome to the podcast. I'm 0:01:21.480 --> 0:01:25.520 Josh Clark. There's Charles W. Chuck Bryant, and we are 0:01:25.560 --> 0:01:27.400 so fly by the seat of our pants. We just 0:01:27.480 --> 0:01:30.440 now decided which of the two episodes we're going to 0:01:30.480 --> 0:01:32.800 record first. That's never happened. I looked at Josh while 0:01:32.800 --> 0:01:35.160 he was talking. I pointed to the thing, and he 0:01:35.240 --> 0:01:39.680 just nodded. That's we're gonna do poop. We're doing poop. Yes. 0:01:40.280 --> 0:01:42.600 I can't wait to hear intro for this, because I 0:01:42.640 --> 0:01:44.720 can't imagine what kind of intro you would have for 0:01:44.840 --> 0:01:48.760 drinking a poop shake exactly zero intro. Okay, now you've 0:01:48.800 --> 0:01:51.080 put me on the spot, all right. Um, I had 0:01:51.120 --> 0:01:53.840 only recently heard of this. You me pointed it out 0:01:53.880 --> 0:01:57.720 to me about six or so months ago. And then 0:01:57.760 --> 0:02:01.360 pressto Obama, change Joe, We've got a an article on 0:02:01.400 --> 0:02:04.440 the site. Finally get this pretty a new article, right, yeah, 0:02:04.520 --> 0:02:08.680 and it was at least October, and the earliest this 0:02:08.720 --> 0:02:11.440 has come up a couple of times in our show already. Yeah, 0:02:11.480 --> 0:02:16.280 we did a little video that's now vanished on fecal transplants. 0:02:16.320 --> 0:02:18.960 That's right. Oh yeah, that's right, that's where it came up. Um, 0:02:19.040 --> 0:02:20.959 and then this but yeah, this article is by a 0:02:21.040 --> 0:02:25.480 dude named Nicholas Gerbas or Jervis. I don't know who 0:02:25.520 --> 0:02:28.680 he is. He's a freelancer. But this guy is top notch. Yeah, 0:02:28.800 --> 0:02:31.480 he wrote some funny sentences, he did. And but it's 0:02:31.560 --> 0:02:35.600 like every every sentence in this article was underlying and highlighted. Yeah, 0:02:35.919 --> 0:02:39.160 very good, comprehensive article on poop shakes, good thick stuff. 0:02:40.080 --> 0:02:46.440 M Um, so chuck, did you know that if you 0:02:46.600 --> 0:02:50.360 are infected with something called the neuro virus, which is 0:02:50.480 --> 0:02:55.760 very frequently contracted in dorms, prisons, cruise ships, aren't they 0:02:55.760 --> 0:03:00.200 all virtually the same thing? Pretty much? When you put oop, 0:03:00.800 --> 0:03:08.440 each gram of stool has literally billions of neuro viruses 0:03:09.360 --> 0:03:12.600 in it. Yeah, and I believe one of the ways 0:03:12.639 --> 0:03:16.120 you can contract this is by eating sushi from fish 0:03:16.200 --> 0:03:18.799 that had been swimming in contaminated waters. Right, Oh, is 0:03:18.800 --> 0:03:20.840 that the same one? The norwalk virus and the neuro 0:03:20.919 --> 0:03:24.680 virus are the same one. Oh okay, Yeah that sounds familiar. 0:03:25.080 --> 0:03:29.919 That was in the first pilot one point all right, um, 0:03:29.960 --> 0:03:32.680 but yeah, okay, So the neuro virus um that you 0:03:32.720 --> 0:03:35.000 can get it from eating sushi, you can also get 0:03:35.000 --> 0:03:39.240 it if you happen to be friendly with a person 0:03:39.280 --> 0:03:43.160 who's just filthy and has the neuro virus and doesn't 0:03:43.160 --> 0:03:46.720 wash their hands after pooping and then shakes your hand 0:03:47.400 --> 0:03:51.600 or feed you like a gummy bear or something with 0:03:51.640 --> 0:03:55.600 their poopy fingers, and um, you accept that gummy bear 0:03:56.160 --> 0:03:58.240 and like maybe their fingers like get inside of your 0:03:58.280 --> 0:04:00.400 mouth just a little bit. Then all of a sudden, 0:04:00.440 --> 0:04:03.800 you have the neurovirus and you're in big, big trouble. 0:04:04.000 --> 0:04:06.520 For the most part, though, it was always regarded as 0:04:06.600 --> 0:04:11.080 like this UM kind of just just a terrible thing 0:04:11.120 --> 0:04:14.840 to have for a few days. Is extremely very virulent, UM, 0:04:15.000 --> 0:04:18.839 extremely easily passed. It could survive for days weeks on 0:04:19.040 --> 0:04:22.520 a surface UM. But ultimately you just pooped a lot, 0:04:22.520 --> 0:04:25.720 you vomited a lot, and then it was done. Not 0:04:25.880 --> 0:04:32.520 so any longer. Thanks to the rise of misprescribed antibiotics UM, 0:04:32.560 --> 0:04:37.599 about fifty of antibiotic prescriptions are considered unnecessary. Yeah, I 0:04:37.720 --> 0:04:40.479 try to avoid it. It's a it's good and it's 0:04:40.560 --> 0:04:42.760 nice that you're doing your part. I try to do 0:04:42.839 --> 0:04:45.640 my part too. And it stinks that, like we have 0:04:45.720 --> 0:04:49.960 to suffer, right because other people are getting antibiotics at 0:04:49.960 --> 0:04:53.000 the drop of a hat. But that's the point and 0:04:53.200 --> 0:04:54.960 one of the one of the reasons why you and 0:04:55.000 --> 0:04:57.320 I choose to suffer. People haven't caught on yet. Is 0:04:57.320 --> 0:05:01.960 because if you expose a virus or bacteria to an antibiotic, 0:05:02.040 --> 0:05:07.200 something intended to kill it, and it it doesn't kill it, 0:05:07.520 --> 0:05:11.400 that antibiotic or that that virus or bacteria has just 0:05:11.480 --> 0:05:15.680 been effectively naturally selected and it goes on to reproduce 0:05:15.920 --> 0:05:20.200 and reproduce and eventually develops resistance to these antibiotics, and 0:05:20.279 --> 0:05:22.920 so the medicine we have becomes useless to it. That's 0:05:22.960 --> 0:05:26.040 happened with Nora virus. It's also happened with another very 0:05:26.160 --> 0:05:31.200 nasty virus called Clostridium difficial. Yeah, it is melli difficial. Difficial, 0:05:31.240 --> 0:05:34.200 but is what French and Spanish for hard and difficult. 0:05:34.400 --> 0:05:35.880 I think so. And the reason they call it that 0:05:35.920 --> 0:05:39.200 is because this is a very intractable bacteria. Yeah, and 0:05:39.240 --> 0:05:41.360 this is uh, it's become a They call it an 0:05:41.360 --> 0:05:43.480 emerging epidemic, which is kind of scary to say that, 0:05:43.520 --> 0:05:48.039 but especially in hospitals, uh, in nursing homes, because it 0:05:48.320 --> 0:05:53.279 generally affects old folks and they will um, I guess 0:05:53.279 --> 0:05:56.880 they're so jacked up on antibiotics that their gut that 0:05:57.040 --> 0:06:00.400 can't kill this thing once it gets in there, well, yes, 0:06:01.320 --> 0:06:04.400 or if they're on antibiotics for something else, like they 0:06:04.600 --> 0:06:07.440 they're in the hospital for something else that they're given antibiotics, 0:06:07.960 --> 0:06:12.680 the antibiotics going and just wipe their guts clean of 0:06:12.880 --> 0:06:16.320 good bacteria and bad bacteria. See, normally we have bacteria 0:06:16.360 --> 0:06:20.480 that fight see difficial. But if it's all gone, then yeah, 0:06:20.560 --> 0:06:24.360 you're in big trouble. The claustradium comes in and finds 0:06:24.440 --> 0:06:26.840 root and gives you a lot of problems and maybe 0:06:26.920 --> 0:06:29.200 kills you. Yeah, it is is a big deal. Um. 0:06:29.240 --> 0:06:34.680 Gastro Intestinal infections as a whole are way up these days. Um. 0:06:34.760 --> 0:06:38.640 The death number doubled from two thousand seven and I 0:06:38.680 --> 0:06:41.960 think more than seventeen thousand people a year in the 0:06:42.080 --> 0:06:48.760 US die from uh, gastro intestinal infections. Yeah. U of 0:06:48.800 --> 0:06:53.320 the gastro intestinal infection fatalities are in patients sixty five 0:06:53.360 --> 0:06:57.599 and older. Sadly, Um, the next biggest age group is 0:06:57.720 --> 0:07:00.960 five and under. Yeah, the only young. And it's a 0:07:01.000 --> 0:07:03.480 really nasty way to die. And two thirds of those 0:07:03.520 --> 0:07:06.800 are the C differiceeals specifically, so, which is why they're 0:07:06.800 --> 0:07:09.360 calling it an epidemic. Um. And the way you die 0:07:09.440 --> 0:07:14.680 from this is you vomit and diarrhea so much that 0:07:14.800 --> 0:07:18.480 you become dehydrated. When you become dehydrated, your electrolytes are 0:07:18.480 --> 0:07:21.560 out of balance. The electrical system that keeps your heart 0:07:21.600 --> 0:07:23.800 and rhythm malfunctions, so maybe you have a heart attack, 0:07:24.240 --> 0:07:28.320 or you have a stroke, um or you uh go 0:07:28.400 --> 0:07:30.960 into shock and die. Yeah, and even if you're young, 0:07:31.000 --> 0:07:33.840 it's important to stay hydrated when you're sick like that. 0:07:33.960 --> 0:07:36.400 Even if you have the stomach flu or something and 0:07:36.400 --> 0:07:38.880 you're vomiting up stuff, you've got to try to at 0:07:38.920 --> 0:07:41.480 least keep some water down. And if you can't, then 0:07:41.560 --> 0:07:44.320 you should probably go to the hospital and have fluids 0:07:44.480 --> 0:07:48.640 introduced intravenously. Yeah, it's not a bad idea, better safe 0:07:48.680 --> 0:07:52.360 than sorry. I always keep an IVY in the trunk 0:07:52.360 --> 0:07:55.280 of my car just in case I start to dehydrate. 0:07:55.400 --> 0:07:57.280 So I think we've made the case that see different 0:07:57.280 --> 0:08:00.200 seal is a big problem, right it is. And the 0:08:00.240 --> 0:08:03.880 fact that it's they call it intractable, like it's just 0:08:03.960 --> 0:08:05.920 really hard to get rid of. Even once you get 0:08:06.000 --> 0:08:10.239 rid of it, Um, there's like a relapse, right Yeah. 0:08:10.520 --> 0:08:13.280 And um, when you're on antibiotics, you have a seven 0:08:13.360 --> 0:08:18.040 to ten seven to ten time greater chance of contracting it. 0:08:18.800 --> 0:08:21.800 And even two months after you finished the course of antibiotics, 0:08:21.840 --> 0:08:24.400 you're still three times it's likely to contract this normal. 0:08:24.480 --> 0:08:26.400 So you really want to stay away from the antibiotics 0:08:26.440 --> 0:08:28.840 if at all possible. Yeah, of course, if you need them, 0:08:28.880 --> 0:08:31.280 take them. We're not advising you to not take things 0:08:31.320 --> 0:08:33.360 to make you better. But if you have the sniffles, 0:08:33.440 --> 0:08:35.800 if you have like a nasal infection or something like 0:08:35.840 --> 0:08:38.679 a sinus infection in then what they call them, you 0:08:38.880 --> 0:08:40.480 kind of need to tough it out for the greater 0:08:40.520 --> 0:08:45.920 good of humanity. All right, let's talk about bacteria and 0:08:46.160 --> 0:08:50.320 what is called the micro biome. Uh, that is an 0:08:50.320 --> 0:08:55.280 ecosystem in your body of little tiny bacteria, like a 0:08:55.360 --> 0:08:59.920 hundred trillion bacteria in the human body doing all kinds 0:08:59.920 --> 0:09:02.920 of good stuff. Yeah, and there's ten times the amount 0:09:02.960 --> 0:09:07.400 of foreign bacterial cells in your body than your cells, 0:09:08.040 --> 0:09:11.839 actual human cells, ten times more, and that's a good thing. 0:09:11.920 --> 0:09:16.080 We've talked about good bacteria and bad bacteria before, and 0:09:16.520 --> 0:09:20.160 probably the the monsters inside this thing, right, what was 0:09:20.200 --> 0:09:24.440 that one? Yeah, probably digestive systems here that too. But 0:09:24.640 --> 0:09:27.800 anyway to recap quickly, we have lots and lots and 0:09:27.840 --> 0:09:32.200 lots of helpful bacteria, and there's a burgeoning field in medicine. 0:09:32.960 --> 0:09:35.760 Some might call it a fringe on the fringe right now, 0:09:36.400 --> 0:09:39.520 but um, it's called medical ecology, and it's kind of neat. 0:09:39.559 --> 0:09:43.600 It's basically like, instead of going to war with your body, 0:09:43.720 --> 0:09:48.480 they're saying you should be more like a gardener and 0:09:49.040 --> 0:09:53.440 manage your body like a garden of all these live 0:09:53.640 --> 0:09:56.800 things inside of you. Flora, bacterial, flora. You don't want 0:09:56.800 --> 0:09:59.160 to kill these things, no, especially not the good ones. 0:09:59.200 --> 0:10:01.640 And that's what we've been doing with antibiotics. We just 0:10:01.679 --> 0:10:05.079 send something in there that kills everything that's right. Uh, 0:10:05.120 --> 0:10:06.960 there's a really cool thing, have you heard the Human 0:10:07.120 --> 0:10:12.040 Microbiome Project have. Um. This is based on examinations of 0:10:12.040 --> 0:10:15.840 two forty two healthy folks that they've tracked for two years, 0:10:16.440 --> 0:10:21.040 and they're basically sequencing genetic material of bacteria recovered from 0:10:21.080 --> 0:10:23.640 sites on the body. And they've recovered more than five 0:10:23.679 --> 0:10:27.560 million jeans at this point, so they're really like mapping 0:10:27.600 --> 0:10:30.800 this stuff out for the next wave of medicine coming 0:10:30.840 --> 0:10:33.280 through down right, Like, that's got to be a pretty 0:10:33.280 --> 0:10:38.320 good first step toward tailoring medicine to avoid killing good stuff. Yeah, 0:10:38.320 --> 0:10:40.280 and this goes along with your hygiene hypothesis that we 0:10:40.400 --> 0:10:43.400 just talked about when we recorded yesterday and the five 0:10:43.440 --> 0:10:48.040 second role, yeah, which is that's probably out already, right yeah, okay, Um, 0:10:48.200 --> 0:10:50.840 but yeah, the hygiene hypothesis is that if you're exposed 0:10:50.880 --> 0:10:56.560 to bacteria, you learned who your body, your microbiome begins 0:10:56.600 --> 0:11:02.079 to include um bacteria that can defend against the bad stuff, 0:11:02.760 --> 0:11:04.679 and so if you're exposed to it early on, you 0:11:04.760 --> 0:11:08.720 have a greater advantage towards um being healthy as an adult, 0:11:08.960 --> 0:11:11.200 having a fewer allergies, that kind of stuff. Have you 0:11:11.200 --> 0:11:13.280 ever had a friend that had a kid that was 0:11:13.640 --> 0:11:17.720 a little cookie with the bure l I've seen it, 0:11:18.000 --> 0:11:21.199 like before you touch my baby here, scored scored, squored 0:11:21.240 --> 0:11:24.440 all over you. Yeah, usually when the baby is very young, 0:11:25.160 --> 0:11:27.800 although I also have friends that like won't touch babies 0:11:27.800 --> 0:11:31.520 because they think they're just dirty. It's hilarious that we're 0:11:31.640 --> 0:11:34.000 I was like, are you. I don't hold babies usually 0:11:34.040 --> 0:11:36.960 because I'm afraid I'm gonna drop them. Um, And I 0:11:36.960 --> 0:11:39.960 thought you just saying football, that's probably one of the problems. Well, 0:11:39.960 --> 0:11:43.560 that's how you carry a baby. The doesn't rhyme go 0:11:44.040 --> 0:11:47.880 facing the armpit, elbow, over the body, all the real 0:11:48.000 --> 0:11:51.319 tight in run like hell, I think that is it. 0:11:51.520 --> 0:11:55.040 I don't think so. I think you cradle and nuzzle. Um. Well, anyway, 0:11:55.040 --> 0:11:56.920 I thought my friend was afraid of dropping the baby, 0:11:56.960 --> 0:11:58.480 and he's like, no, I don't touch them because there's 0:11:58.480 --> 0:12:01.520 just like bags of germs. All humans are filthy dirty, 0:12:01.679 --> 0:12:04.680 and babies just don't appear that way because they haven't 0:12:04.720 --> 0:12:07.600 been around long enough to stink really bad. You know, 0:12:07.640 --> 0:12:10.439 they smell all downy sweet, and you just from the 0:12:10.520 --> 0:12:12.559 day you're born, you start smelling worse and worse and 0:12:12.640 --> 0:12:15.200 worse until the day you die. Have puppy breath to start. 0:12:15.320 --> 0:12:19.600 I remember going, man, I remember my father's bathroom experience 0:12:19.600 --> 0:12:21.880 as being a kid and being like, oh my lord, like, 0:12:22.760 --> 0:12:24.440 am I going to smell that way one day? Yeah? 0:12:24.440 --> 0:12:27.200 I remember that too, and then that mixed with like 0:12:27.880 --> 0:12:31.400 shaving cream smell, and you don't like it now I 0:12:31.440 --> 0:12:54.439 smell that way. I know you don't. You smell fine. 0:12:56.040 --> 0:13:00.520 Uh So back to bacteria. Um. If we're talking about 0:13:00.679 --> 0:13:02.920 millions and millions and millions of these in our body, 0:13:03.120 --> 0:13:07.600 um our mouth has hundreds of thousands of bacteria species, 0:13:07.800 --> 0:13:10.439 not just bacteria and they are in our teeth and 0:13:10.480 --> 0:13:12.640 our gums, on our tongue. There in our lungs, which 0:13:12.640 --> 0:13:14.640 we didn't think we used to have them in our lungs. 0:13:15.000 --> 0:13:19.240 Apparently there's two thousand per square centimeter. And uh, the 0:13:19.280 --> 0:13:22.920 gut is where you're gonna find some serious action to 0:13:23.000 --> 0:13:26.199 thirty thousand different species of bacteria. Yeah, and they live 0:13:26.200 --> 0:13:33.480 in colonies. Were starting to learn colonies, Um, where they they. 0:13:33.520 --> 0:13:35.520 I guess bacteria kind of likes to stay with their 0:13:35.520 --> 0:13:37.959 own ilk. And if you put it all together, you've 0:13:37.960 --> 0:13:41.160 got like a whole neighborhood of bacteria. But um, I 0:13:42.080 --> 0:13:44.320 am pretty confident. And once we start to figure out 0:13:44.360 --> 0:13:46.680 like this colony tends to live in this part of 0:13:46.679 --> 0:13:49.120 the body, and this colony lives here, I'll bet it 0:13:49.120 --> 0:13:52.360 helps things function more correctly. And if you move colonies around, 0:13:52.400 --> 0:13:57.480 I'll bet you you find dysfunction, life balance or not life. Well, 0:13:57.480 --> 0:14:00.000 I think that's all the reasons why it's still free. 0:14:00.080 --> 0:14:02.920 G Like you you you you just kind of put 0:14:02.920 --> 0:14:06.320 your finger on it, like there's balance and all that too, 0:14:06.400 --> 0:14:09.000 but esoteric, right, But as as you and I know, 0:14:09.240 --> 0:14:12.680 homeostasis is the goal of everything that's right. We've talked 0:14:12.679 --> 0:14:14.560 about it before. So you've got in your mouth, you've 0:14:14.559 --> 0:14:18.120 got bacteria in your guts, and I mean, I think 0:14:18.120 --> 0:14:22.680 the fact that bacteria have more cells in our bodies 0:14:22.680 --> 0:14:26.000 than we do kind of supports this idea that um 0:14:26.080 --> 0:14:30.000 Nicholas Gerbis Gerbis pointed out is that bacteria probably the 0:14:30.040 --> 0:14:33.040 most successful life forms on planet Earth. Yeah. What are 0:14:33.040 --> 0:14:37.320 these guys doing? Oh well, they are breaking down things 0:14:37.400 --> 0:14:40.440 and too other things. They break down nitrogen into the 0:14:40.520 --> 0:14:43.520 in the soil to make it absorbable for plants. They 0:14:43.520 --> 0:14:46.720 produce vitamins in your gut. Yeah, bacteria do. Yeah, how 0:14:46.720 --> 0:14:51.120 about that? They produce oxygen that we breathe. There's waste processes. 0:14:51.320 --> 0:14:57.200 They help maintain your protective qualities of your skin, which 0:14:57.240 --> 0:15:00.600 is nice. They those plants, they kind of they turn 0:15:00.640 --> 0:15:03.440 the tables on those plants. They break down nitrogen the 0:15:03.480 --> 0:15:05.960 soil four plants to take up, and then when we 0:15:06.040 --> 0:15:08.240 eat the plants, they break the plants down into a 0:15:08.240 --> 0:15:13.400 digestible slurry grass. What's it called bolus time? I think 0:15:13.800 --> 0:15:19.160 time time than bolus time. They also help prevent, prevent 0:15:19.200 --> 0:15:21.560 and reduced swelling, which is a big deal because swelling 0:15:22.560 --> 0:15:27.000 can be one of the danger factors if you're sick 0:15:27.160 --> 0:15:30.520 or injured. A lot of times people die simply because 0:15:31.320 --> 0:15:34.360 they can't get the swelling down in order to perform 0:15:34.560 --> 0:15:37.160 procedures they need to perform. So thank you back Terry 0:15:37.280 --> 0:15:39.440 for helping with that. Um. And then we were talking 0:15:39.480 --> 0:15:43.640 about babies to chuck, Um, if you wouldn't hold the baby, 0:15:43.680 --> 0:15:46.200 then you probably shouldn't like shake hands with the baby's mother, 0:15:46.280 --> 0:15:48.880 because that's where the baby gets most of his or 0:15:48.880 --> 0:15:52.840 her initial bacteria's from the mother. There's about six hundred 0:15:52.920 --> 0:15:57.840 different species found in breast milk. Um. The sugars and 0:15:57.880 --> 0:16:02.600 breast milk go directly towards motivating bacteria in the baby's gut. Yeah. 0:16:03.040 --> 0:16:09.040 There's a change in um, the vaginal microbiome, Yeah, where 0:16:09.240 --> 0:16:12.720 they think that possibly the baby is basically coated in 0:16:12.760 --> 0:16:17.000 this upon entry into the world. Yeah. That's called Lactobacillus 0:16:17.160 --> 0:16:22.720 john sony. And that is present when you're pregnant and 0:16:22.840 --> 0:16:27.320 you're vaginal micro biome, right, and they think that you 0:16:27.480 --> 0:16:29.080 get coated on the way out. Yeah, And then all 0:16:29.120 --> 0:16:31.880 of a sudden you're like, Okay, I've got some defenses here, 0:16:32.480 --> 0:16:34.480 and these guys are going to be my friends for 0:16:34.480 --> 0:16:37.520 the rest of my life. Well, the lacto basilus actually 0:16:37.560 --> 0:16:41.480 helps them digest the milk. So um, little little babies 0:16:41.520 --> 0:16:44.280 that come out. That's why they say, if you're born 0:16:44.360 --> 0:16:48.000 in a cesarean fashion, then you might not have what 0:16:48.080 --> 0:16:50.800 you need to digest the milk. You might have problems there, 0:16:51.200 --> 0:16:56.440 you might have uh fewer defenses against IBD, inflammatory bowe 0:16:56.480 --> 0:17:01.880 disease and um what else Merca staph infection. Well, yeah, 0:17:01.960 --> 0:17:05.960 that skin. They think that there's studies that suggest that 0:17:06.000 --> 0:17:09.439 you're more prone to Merca infections on the skin. UM. 0:17:09.480 --> 0:17:14.080 This is still very much under debate, huge debate between 0:17:14.280 --> 0:17:18.840 cesarean and natural birth stuff. It's like a hornet's nest man. 0:17:19.240 --> 0:17:21.639 But they think that you know, there there is a 0:17:21.640 --> 0:17:27.800 definite link they imagine between amritable bowel syndrome or inflammatory 0:17:27.800 --> 0:17:32.439 bowel disorder sorry UM, which includes like Crohn's disease and 0:17:32.520 --> 0:17:35.400 all sort of colitis um. And it's a big deal. 0:17:35.760 --> 0:17:38.080 You can lose parts of your intestines, you can die, 0:17:38.280 --> 0:17:41.400 you can become malnourished UM. And there's like a one 0:17:41.440 --> 0:17:47.240 point seven billion dollar expense in healthcare just from inflammatory 0:17:47.240 --> 0:17:51.240 bowel disorder alone in the US. UM. And they believe 0:17:51.280 --> 0:17:55.199 that that's linked to some sort of problem with bacteria 0:17:55.280 --> 0:17:59.960 in the guts. So all of this small talk about 0:18:00.040 --> 0:18:03.840 bacteria has been leading to the setup of this podcast, 0:18:04.200 --> 0:18:09.200 which is drinking the poop shake. Yeah, the fecal transplant, 0:18:10.240 --> 0:18:12.080 and they call it a transplant, and it makes it 0:18:12.160 --> 0:18:17.320 sound a little more like a medical procedure than I 0:18:17.359 --> 0:18:21.080 thought it was. Uh. There's no cutting, there's no laser ing, 0:18:21.640 --> 0:18:25.520 there's nothing like that. Um, this has been practiced. Something 0:18:25.560 --> 0:18:28.919 like this has been around since fourth century China. I 0:18:29.000 --> 0:18:31.400 was looking. I couldn't find anything on that. Could you 0:18:31.119 --> 0:18:35.400 really now, I couldn't. We should email the author here. Um. 0:18:35.440 --> 0:18:38.600 But it has been around in earnest since n Dr 0:18:38.640 --> 0:18:45.320 Ben Eisenman UH from Denver General Hospital pioneered this. Uh. 0:18:45.520 --> 0:18:48.879 I guess it's a procedure. I was gonna say technique. Um, 0:18:49.000 --> 0:18:52.040 And it really didn't come around in earnest until about 0:18:52.040 --> 0:18:56.760 two thousand. So here's how it works. You're donor gets 0:18:56.800 --> 0:19:01.920 screened for hepatide us in HIV and other disease causing 0:19:01.960 --> 0:19:04.919 germs that you don't want. They take the stool of 0:19:05.000 --> 0:19:09.960 the donor poop poop, they blend it um with saline 0:19:10.240 --> 0:19:13.720 or this is so gross. Four percent milk in a 0:19:13.720 --> 0:19:17.639 medical blender. Yeah, sure, it's not that Queason art. I 0:19:17.680 --> 0:19:20.160 bet it is a Queason art sense that you would 0:19:20.240 --> 0:19:22.840 use milk if you want to propagate moss on something. 0:19:23.600 --> 0:19:25.760 A little bit of buttermilk, a little bit of um 0:19:25.760 --> 0:19:29.680 sugar in a and just take some moss and throw 0:19:29.720 --> 0:19:32.800 it in a blender altogether, press, blend, take it and 0:19:32.800 --> 0:19:35.640 painted on whatever you want. It's right and it will grow. 0:19:35.920 --> 0:19:39.480 See our moss podcast for that one. Yeah. Uh. So basically, 0:19:39.560 --> 0:19:42.719 you have the stool sample of the poop four percent 0:19:42.800 --> 0:19:47.880 milk and in milkshake machine and you mix it up 0:19:47.920 --> 0:19:50.920 and you feed it to the patient through Uh, you 0:19:50.960 --> 0:19:53.960 don't have to drink it. No, there's different ways to 0:19:54.040 --> 0:19:57.000 introduce it, but one of them it does end up 0:19:57.040 --> 0:19:59.600 in your stomach, and I don't understand how you don't 0:19:59.640 --> 0:20:02.040 just in immediately throw it right back up. All right. 0:20:02.080 --> 0:20:04.480 So the two methods um that Josh will explain are 0:20:04.560 --> 0:20:08.919 nassa gastric and nasso duodenal. Yeah, we never figured that 0:20:08.920 --> 0:20:12.720 one out in our Digestive episode the remember they duodenum 0:20:13.240 --> 0:20:17.320 duodenum um. Yeah, Well that's a tube that goes through 0:20:17.320 --> 0:20:19.800 your nose and if it's naso gastric it ends in 0:20:19.840 --> 0:20:23.240 your stomach, which means you have poop going directly into 0:20:23.280 --> 0:20:25.960 your stomach. And don't think that four percent milk makes 0:20:25.960 --> 0:20:28.560 it any easier to take through your nose, through your 0:20:28.560 --> 0:20:33.680 throat into your stomach. Or the nasal duodenum goes through 0:20:33.720 --> 0:20:36.680 your nose into your stomach and then into your intestine, 0:20:36.720 --> 0:20:40.439 so it bypasses your stomach and it goes directly to 0:20:40.520 --> 0:20:45.600 where you want it. The intestines. Wow when that. You 0:20:45.640 --> 0:20:50.439 can also do a a an enema that's designed to 0:20:50.520 --> 0:20:56.159 stay in rather than flush back out. Um enema. Yeah, 0:20:56.200 --> 0:20:57.840 what do you think? I say, I don't know. I 0:20:57.920 --> 0:21:00.359 just they should call the other ones out of us, 0:21:00.359 --> 0:21:05.240 I guess. Or a kolonoscope, not a kaleidoscope, although that 0:21:05.240 --> 0:21:08.640 would work if you turned it around and I guess 0:21:08.680 --> 0:21:11.400 broke all the glass out ahead of time. Is there 0:21:11.440 --> 0:21:14.879 just be like a funnel. Then that's true. Um. But 0:21:15.040 --> 0:21:18.080 the point is that you have someone else's poop, a 0:21:18.080 --> 0:21:21.600 healthier person's poop, in your stomach, and they expect that 0:21:21.720 --> 0:21:26.320 about of the living bacteria found in that poop is 0:21:26.359 --> 0:21:29.240 going to stick around and you're intestines, what you're doing. 0:21:29.280 --> 0:21:32.760 The whole point of a fecal transplant is to repopulate 0:21:33.280 --> 0:21:36.800 your gut flora so that your immune system can get 0:21:36.800 --> 0:21:39.480 back in order. The best way they thought about to 0:21:39.520 --> 0:21:43.480 do it. Yeah, they have. They have another cocktail that 0:21:43.560 --> 0:21:46.280 they're working on, which is just a bunch of like 0:21:47.359 --> 0:21:49.200 bacteria that I guess you could take as a pill. 0:21:49.960 --> 0:21:56.440 But man, this works. Yeah, it seems to UM. One 0:21:56.440 --> 0:21:59.160 of the stats we have here is that people who 0:21:59.160 --> 0:22:02.359 have undergone this and it's still well, we'll get to help. 0:22:02.440 --> 0:22:06.560 Often it's practice here in a second but UM one 0:22:06.680 --> 0:22:09.600 study found that long term follow up, seventy seven fecal 0:22:09.680 --> 0:22:14.280 transplant patients reported a CURATE after just one of these 0:22:14.800 --> 0:22:20.120 and percent uh if you married that with additional probiotics 0:22:20.119 --> 0:22:24.040 and antibotics and or an additional poop jake right for 0:22:24.240 --> 0:22:28.120 c deficial. Yeah, that's percent. That's awesome. I don't think 0:22:28.119 --> 0:22:30.520 that there's anything that has that kind of success rate. 0:22:31.680 --> 0:22:35.920 Maybe aspirin maybe so. But yeah, it's definitely been shown 0:22:35.960 --> 0:22:39.280 to work. And you know it is fringe, but you 0:22:39.320 --> 0:22:43.280 can still get it done in hospitals. That's where you 0:22:43.280 --> 0:22:44.760 want to do it. Yeah, you don't want to do 0:22:44.800 --> 0:22:47.240 this at home. This is not UM. In fact, a 0:22:47.240 --> 0:22:49.600 couple of the best sentences in this article or in 0:22:49.640 --> 0:22:52.760 this section. First of all, the preparation you prepare like 0:22:52.800 --> 0:22:55.639 you would for a colonoscopy. But as our who's who 0:22:55.640 --> 0:22:59.320 who wrote this again, Nicholas gerbis Gurbus Gerbas put it 0:22:59.400 --> 0:23:02.760 this way, Nikki G. Nikki G says, the patient prepares 0:23:02.800 --> 0:23:06.160 for the procedure via the traditional taking no prisoners date 0:23:06.200 --> 0:23:09.840 with the thunderbucket ritual used by colonoscopy patients. Yeah. He 0:23:09.880 --> 0:23:14.280 went from like science writer, science writer, science writer, Mad magazine. Yeah. 0:23:15.520 --> 0:23:17.399 And then he also says, uh, this is not a 0:23:17.440 --> 0:23:20.760 great dy project because stool is a level to bio 0:23:20.800 --> 0:23:24.800 hazard number two, if you don't test the samples for disease, 0:23:24.880 --> 0:23:27.760 you could end up in pain. And then third, remind 0:23:27.840 --> 0:23:30.080 us never to drink a frozen margharita at your house. 0:23:31.080 --> 0:23:33.520 He just went like funny for one paragraph and then 0:23:33.600 --> 0:23:36.280 right back to the business. Right. Well, Um, he says 0:23:36.359 --> 0:23:39.560 that you want to screen the stool that you're putting 0:23:39.600 --> 0:23:45.800 into the patient, and um insurance doesn't cover this, not yet, no, 0:23:45.920 --> 0:23:47.960 but they think it will as early as this year, 0:23:48.160 --> 0:23:52.280 earlier this year, soon early, um. But even still it's 0:23:52.320 --> 0:23:55.320 not very cost prohibitive. It's about a thousand dollars. I 0:23:55.320 --> 0:23:58.240 saw there's a hospital in Madison, Wisconsin that does it. 0:23:59.400 --> 0:24:02.119 That's pretty it's not bad. And most of that cost 0:24:02.280 --> 0:24:05.320 is for screening the stool for disease. I thought it 0:24:05.320 --> 0:24:08.879 had been the milk or yeah, or pressing them blend 0:24:08.920 --> 0:24:16.600 buttons right, or holding your breath all the nose clips. Um. 0:24:16.680 --> 0:24:19.399 So uh. One of the interesting things you're moving forward 0:24:19.480 --> 0:24:21.200 is how this is going to be, like you said, 0:24:21.200 --> 0:24:23.679 affect insurance, and how it's going to be classified if 0:24:23.720 --> 0:24:28.359 it if and when it becomes like super legit because um, 0:24:28.400 --> 0:24:31.880 what is on the horizon is that the f d 0:24:31.920 --> 0:24:36.520