1 00:00:03,200 --> 00:00:11,240 Speaker 1: From Bloomberg News and iHeartRadio. It's the big take. I'm Wescasova. Today. 2 00:00:11,360 --> 00:00:15,800 Speaker 1: New drugs to treat obesity really work. The question is 3 00:00:15,920 --> 00:00:25,639 Speaker 1: who will get them and who won't. There's been a 4 00:00:25,640 --> 00:00:29,200 Speaker 1: lot of news coverage lately about ozepic and other drugs 5 00:00:29,400 --> 00:00:32,160 Speaker 1: like it that are shown to be effective at helping 6 00:00:32,240 --> 00:00:36,360 Speaker 1: people living with obesity to lose weight. The downside, you 7 00:00:36,479 --> 00:00:39,839 Speaker 1: often have to stay on them, and they are expensive 8 00:00:40,040 --> 00:00:44,120 Speaker 1: thousands of dollars a year. Some insurance companies are reluctant 9 00:00:44,120 --> 00:00:47,800 Speaker 1: to cover them, even with a doctor's prescription. And this 10 00:00:48,000 --> 00:00:51,680 Speaker 1: is stirring up all kinds of questions about taking obesity 11 00:00:51,760 --> 00:00:55,400 Speaker 1: seriously as a disease and about how healthcare is often 12 00:00:55,600 --> 00:00:57,880 Speaker 1: very different from people who can afford to pay for 13 00:00:57,960 --> 00:01:00,480 Speaker 1: costly treatments and those who can't. 14 00:01:00,720 --> 00:01:02,840 Speaker 2: And now you know, we're at a point where people 15 00:01:02,880 --> 00:01:05,640 Speaker 2: are more accepting of it is more about people's chemistry 16 00:01:05,680 --> 00:01:07,759 Speaker 2: than about their character, right, This is not a character 17 00:01:07,760 --> 00:01:11,120 Speaker 2: of law. This is a biochemical process that creates the 18 00:01:11,160 --> 00:01:13,520 Speaker 2: disease of obesity, just like you know, similar to what 19 00:01:13,720 --> 00:01:16,319 Speaker 2: was a struggle for mental health for very many years 20 00:01:16,440 --> 00:01:19,160 Speaker 2: until there was an increased awareness and increased focus. 21 00:01:19,680 --> 00:01:23,760 Speaker 1: That's doctor Angela Fitch. She specializes in treating obesity, and 22 00:01:23,800 --> 00:01:27,200 Speaker 1: we're going to hear more from her later in the show. First, 23 00:01:27,240 --> 00:01:30,720 Speaker 1: Bloomberg reporters am A Court and Robert Langreth. They've been 24 00:01:30,760 --> 00:01:34,520 Speaker 1: covering the upsides and downsides of these medications and the 25 00:01:34,600 --> 00:01:39,319 Speaker 1: back and forth over who should foot the bill. Emma, 26 00:01:39,360 --> 00:01:42,440 Speaker 1: can you start by telling us how do these drugs work? 27 00:01:43,360 --> 00:01:45,800 Speaker 3: The drugs have a bunch of different names. I think 28 00:01:45,840 --> 00:01:49,560 Speaker 3: people are maybe most familiar with ozembic, which is actually 29 00:01:49,640 --> 00:01:51,240 Speaker 3: not specifically a. 30 00:01:51,480 --> 00:01:52,520 Speaker 4: Drug for weight loss. 31 00:01:52,520 --> 00:01:55,040 Speaker 3: It's a drug for diabetes that happens to produce some 32 00:01:55,080 --> 00:01:58,560 Speaker 3: weight loss. Basically, there's a group of these drugs ozempic. 33 00:01:59,200 --> 00:02:02,000 Speaker 3: The one that's been specifically approved for obesity right now 34 00:02:02,080 --> 00:02:05,480 Speaker 3: is called Wagovi. There's an earlier one called Sexenda. There's 35 00:02:05,520 --> 00:02:09,200 Speaker 3: one that's sort of going through the regulatory process soon 36 00:02:09,280 --> 00:02:13,120 Speaker 3: for obesity called Munjaro. These drugs are all part of 37 00:02:13,120 --> 00:02:17,040 Speaker 3: a class called GLP one receptor agonists, and basically the 38 00:02:17,040 --> 00:02:19,960 Speaker 3: way they work is they help people feel full, they 39 00:02:20,040 --> 00:02:24,639 Speaker 3: eat less, and people lose weight. The catches that people 40 00:02:24,680 --> 00:02:26,720 Speaker 3: may need to take them long term to keep the 41 00:02:26,720 --> 00:02:29,120 Speaker 3: weight loss off they've done some studies where people quit 42 00:02:29,160 --> 00:02:32,480 Speaker 3: taking the drugs and they regained a lot of weight. 43 00:02:33,080 --> 00:02:35,799 Speaker 3: But the main factor here to think about is these 44 00:02:35,800 --> 00:02:39,600 Speaker 3: are drugs that replicate a hormone that exists naturally, but 45 00:02:39,840 --> 00:02:43,680 Speaker 3: at pretty high pharmaceutical levels of sort of mimicking this 46 00:02:43,720 --> 00:02:47,320 Speaker 3: hormone in the body, and it comes with some side effects. 47 00:02:47,600 --> 00:02:52,760 Speaker 3: A lot of people have nausea, diarrhea, constipation, but they're 48 00:02:52,760 --> 00:02:56,920 Speaker 3: considered relatively safe because they have been studied in diabetes 49 00:02:56,960 --> 00:02:57,680 Speaker 3: for many years. 50 00:02:58,720 --> 00:03:02,359 Speaker 5: The interesting thing to me watching the pharmaceutical industry for 51 00:03:02,440 --> 00:03:05,200 Speaker 5: so many years, there's been a long history of attempts 52 00:03:05,200 --> 00:03:07,680 Speaker 5: to develop weight loss drugs that have run into lots 53 00:03:07,680 --> 00:03:11,040 Speaker 5: of problems or have been many examples of previous weight 54 00:03:11,080 --> 00:03:14,480 Speaker 5: loss pills that had to have recalls for safety reasons. 55 00:03:14,880 --> 00:03:17,440 Speaker 5: This class, which is showing, you know, more efficacy than 56 00:03:17,480 --> 00:03:20,480 Speaker 5: previous weight loss drugs before, in some sense, kind of 57 00:03:20,480 --> 00:03:22,280 Speaker 5: came out of left field. It really came out of 58 00:03:22,320 --> 00:03:26,160 Speaker 5: diabetes research. These GLP and hormones that they're essentially mimicking 59 00:03:26,200 --> 00:03:28,160 Speaker 5: in these drugs. It turns out that in addition to 60 00:03:28,320 --> 00:03:30,920 Speaker 5: helping regulate blood sugar, which is the reason they were 61 00:03:30,919 --> 00:03:34,720 Speaker 5: originally discovered these hormones also have important roles in sending 62 00:03:34,880 --> 00:03:37,280 Speaker 5: fullness signals to the brain. And when they did some 63 00:03:37,360 --> 00:03:39,720 Speaker 5: of the early trials or the early versions of these 64 00:03:39,800 --> 00:03:43,040 Speaker 5: drugs and diabetes, you know, they discover that people with 65 00:03:43,120 --> 00:03:46,560 Speaker 5: diabetes they lost weight, but for a long time that 66 00:03:46,800 --> 00:03:50,800 Speaker 5: wasn't the main focus the research and drug companies didn't 67 00:03:51,040 --> 00:03:54,040 Speaker 5: until recently really pursue the weight loss angle of them 68 00:03:54,080 --> 00:03:56,800 Speaker 5: as an O B city standalone agent. So that's only 69 00:03:56,840 --> 00:04:01,360 Speaker 5: started accelerating recently as they've developed much more potent, longer 70 00:04:01,400 --> 00:04:03,960 Speaker 5: acting versions of these drugs and lo and behold, when 71 00:04:04,000 --> 00:04:06,880 Speaker 5: they did that, the amount of weight loss that was 72 00:04:06,880 --> 00:04:09,120 Speaker 5: produced in some of these trials, you know, went up dramatically, 73 00:04:09,160 --> 00:04:12,240 Speaker 5: and that's kind of the big surprise. It has tons 74 00:04:12,280 --> 00:04:14,560 Speaker 5: of drug company executive just like you know, almost like 75 00:04:14,600 --> 00:04:17,120 Speaker 5: salivating over the potential enormous market size. 76 00:04:18,600 --> 00:04:20,359 Speaker 1: How much weight can you lose on them? Like? How 77 00:04:20,440 --> 00:04:24,200 Speaker 1: much more effective are they than previous efforts to make 78 00:04:24,240 --> 00:04:25,159 Speaker 1: a weight loss drug. 79 00:04:25,880 --> 00:04:28,960 Speaker 5: Well, there are some of the most significantly effective drugs 80 00:04:28,960 --> 00:04:31,279 Speaker 5: of single agents that have ever been developed from what 81 00:04:31,320 --> 00:04:34,560 Speaker 5: we see so far, especially the newer ones and some 82 00:04:34,600 --> 00:04:37,360 Speaker 5: of those with GOVI, which is Nova Noordius drug, which 83 00:04:37,400 --> 00:04:40,640 Speaker 5: is a higher dose version of a zempeic that produces 84 00:04:40,680 --> 00:04:44,000 Speaker 5: around thirty pounds of weight loss. And Eli Lilly has 85 00:04:44,040 --> 00:04:48,280 Speaker 5: a diabetes drug called Munjaro that's also testing for obesity, 86 00:04:48,720 --> 00:04:51,360 Speaker 5: and in their early big trial, in their first big 87 00:04:51,400 --> 00:04:55,240 Speaker 5: trial of that drug, that produced at high doses around 88 00:04:55,240 --> 00:04:57,279 Speaker 5: fifty pounds of weight loss, which is kind of like 89 00:04:57,360 --> 00:05:00,440 Speaker 5: almost an unprecedented thing, you know, for a single drug 90 00:05:00,440 --> 00:05:02,920 Speaker 5: and a big trial. The sense is like almost all 91 00:05:02,960 --> 00:05:05,000 Speaker 5: sorts of drug companies just kind of racing to get 92 00:05:05,000 --> 00:05:05,520 Speaker 5: in the field. 93 00:05:06,360 --> 00:05:09,240 Speaker 1: They clearly work, but there's kind of a big downside. 94 00:05:09,279 --> 00:05:12,400 Speaker 1: They are not cheap, is that right, Emma? 95 00:05:12,520 --> 00:05:15,479 Speaker 3: Yeah, So these drugs, you know, depending on which specific 96 00:05:15,560 --> 00:05:18,960 Speaker 3: drugs you're talking about, like the class generally costs more 97 00:05:19,000 --> 00:05:22,560 Speaker 3: than ten thousand dollars a year, with GOV specifically is 98 00:05:22,600 --> 00:05:25,919 Speaker 3: more like seventeen thousand dollars a year. And you know, 99 00:05:26,000 --> 00:05:30,360 Speaker 3: typically insurance pays for medication, right, I mean, they don't 100 00:05:30,360 --> 00:05:32,480 Speaker 3: pay for everything, and they might give you a hard time, 101 00:05:32,600 --> 00:05:35,560 Speaker 3: but if you have a disease, typically you know, you 102 00:05:35,600 --> 00:05:38,960 Speaker 3: can get insurance coverage for treatments, you know, more or less. 103 00:05:39,520 --> 00:05:43,240 Speaker 3: In this case, though, obesity is treated pretty differently from 104 00:05:43,279 --> 00:05:46,560 Speaker 3: other conditions, and that there isn't like sort of routine, 105 00:05:46,680 --> 00:05:49,520 Speaker 3: regular coverage for weight loss drugs. And so, you know, 106 00:05:49,560 --> 00:05:52,240 Speaker 3: we found in like our reporting that you know, whether 107 00:05:52,279 --> 00:05:54,680 Speaker 3: you're looking at private insurers, like if you work at 108 00:05:54,680 --> 00:05:57,240 Speaker 3: a big company and you have private insurance, whether you're 109 00:05:57,360 --> 00:06:00,800 Speaker 3: getting insurance through Medicare, which is for elderly people in 110 00:06:00,839 --> 00:06:04,000 Speaker 3: the US, to get health insurance coverage Medicaid, which is 111 00:06:04,040 --> 00:06:09,040 Speaker 3: for low income people, generally, coverage is really really spotty. 112 00:06:09,200 --> 00:06:13,080 Speaker 3: You know, a minority of insurers are covering drugs like 113 00:06:13,120 --> 00:06:16,839 Speaker 3: these for weight loss. Medicare isn't covering it at all, 114 00:06:17,360 --> 00:06:20,360 Speaker 3: and there's been a big push from pharma to try 115 00:06:20,400 --> 00:06:21,280 Speaker 3: to change that. 116 00:06:21,880 --> 00:06:26,560 Speaker 5: We surveyed all fifty states Medicaid plans and only roughly 117 00:06:26,600 --> 00:06:30,200 Speaker 5: eleven states provided you know, broad coverage for BC drugs, 118 00:06:30,240 --> 00:06:34,640 Speaker 5: and many many states excluded it entirely. Private insurance coverage 119 00:06:34,720 --> 00:06:36,680 Speaker 5: was maybe a little bit better, but it varies all 120 00:06:36,720 --> 00:06:40,000 Speaker 5: over the map. Roughly from the surveys, we see maybe 121 00:06:40,040 --> 00:06:43,880 Speaker 5: a quarter of private plans we'll cover BCD drugs. It's 122 00:06:43,880 --> 00:06:46,400 Speaker 5: one of those rare categories in the US. Insurance feel 123 00:06:46,400 --> 00:06:49,720 Speaker 5: they can just like blanket not cover and not get 124 00:06:49,760 --> 00:06:50,599 Speaker 5: too much pushback. 125 00:06:51,000 --> 00:06:53,240 Speaker 3: So what that means is if you're a person and 126 00:06:53,279 --> 00:06:55,839 Speaker 3: you have a body mass index of over a certain 127 00:06:55,880 --> 00:06:59,280 Speaker 3: threshold for OBCD it's thirty plus. So you go to 128 00:06:59,400 --> 00:07:04,240 Speaker 3: the doctor, your doctor weighs you, they say, you have obesity. 129 00:07:04,480 --> 00:07:07,960 Speaker 3: We're going to prescribe you this new, cutting edge medication 130 00:07:08,160 --> 00:07:11,320 Speaker 3: that works really well to help people lose weight. You 131 00:07:12,280 --> 00:07:15,080 Speaker 3: try to get that prescription covered by insurance, and it 132 00:07:15,160 --> 00:07:17,960 Speaker 3: is going to be a big battle, and chances are 133 00:07:18,320 --> 00:07:19,560 Speaker 3: you're going to lose that battle. 134 00:07:20,760 --> 00:07:24,280 Speaker 1: Bob. What is the insurance industry's reason for not covering 135 00:07:24,280 --> 00:07:24,880 Speaker 1: these drugs. 136 00:07:25,400 --> 00:07:28,720 Speaker 5: One of the reasons is simply cost. There's roughly half 137 00:07:28,760 --> 00:07:31,600 Speaker 5: the adult population would qualify under the label, under the 138 00:07:31,640 --> 00:07:34,640 Speaker 5: official FDA label you know, for these drugs, So if 139 00:07:34,720 --> 00:07:37,960 Speaker 5: everyone used it that could potentially qualify, the costs would 140 00:07:38,000 --> 00:07:42,840 Speaker 5: just be enormous. Some industry financial analyst estimates are estimating 141 00:07:42,880 --> 00:07:45,640 Speaker 5: that this class of drugs could eventually have sales of 142 00:07:45,680 --> 00:07:48,320 Speaker 5: one hundred and fifty billion dollars a year between obesity 143 00:07:48,320 --> 00:07:50,640 Speaker 5: and diabetes, like basically making one of the best selling 144 00:07:50,680 --> 00:07:53,000 Speaker 5: you know, classes of drugs ever. 145 00:07:53,560 --> 00:07:55,800 Speaker 3: You know. I think another piece of it is they 146 00:07:55,840 --> 00:07:58,080 Speaker 3: don't have to cover it. There is a precedent for 147 00:07:58,120 --> 00:08:01,760 Speaker 3: not covering it. Medicare doesn't cover it. Medicare is sort 148 00:08:01,800 --> 00:08:04,960 Speaker 3: of the gold standard for coverage, right. If Medicares cover something, 149 00:08:05,400 --> 00:08:09,600 Speaker 3: private insurers typically follow. But it's interesting because there is 150 00:08:10,040 --> 00:08:14,280 Speaker 3: pressure already to cover the stuff, and it's going to 151 00:08:14,520 --> 00:08:18,400 Speaker 3: only increase as you know, Novo Nordisk, the maker of 152 00:08:18,520 --> 00:08:22,360 Speaker 3: ozembic and magov puts more money into this fight. You know, 153 00:08:22,400 --> 00:08:25,560 Speaker 3: if Eli Lilly gets approved for obesity, you're going to 154 00:08:25,640 --> 00:08:29,200 Speaker 3: have more and more companies coming into this space, lobbying 155 00:08:29,240 --> 00:08:33,800 Speaker 3: in Washington to change coverage, pushing private plans. You already 156 00:08:33,800 --> 00:08:37,040 Speaker 3: have patients going to their HR office and saying, you know, 157 00:08:37,520 --> 00:08:40,040 Speaker 3: why don't you cover with goov? You know, my companies 158 00:08:40,400 --> 00:08:42,400 Speaker 3: to have this great health insurance. You know, I'm paying 159 00:08:42,400 --> 00:08:44,760 Speaker 3: top dollar for why aren't you paying for this drug? 160 00:08:45,679 --> 00:08:45,920 Speaker 4: You know. 161 00:08:45,960 --> 00:08:48,600 Speaker 5: One of the points that insurers make is that, yes, 162 00:08:48,679 --> 00:08:50,839 Speaker 5: these drugs do cause a lot of weight loss. Are 163 00:08:50,880 --> 00:08:53,760 Speaker 5: not disputing that, but they say that the drugs, you know, 164 00:08:53,920 --> 00:08:57,360 Speaker 5: haven't been proven to reduce you know, kind of hard 165 00:08:57,679 --> 00:09:01,800 Speaker 5: clinical health outcomes, like they haven't been proven to reduce 166 00:09:01,840 --> 00:09:04,120 Speaker 5: heart attacks and strokes, So they haven't been proven to 167 00:09:04,120 --> 00:09:07,560 Speaker 5: reduce sleep apnea or other complications of obesity, and the 168 00:09:07,600 --> 00:09:10,679 Speaker 5: insurers are right about that. And what the drug companies 169 00:09:10,679 --> 00:09:13,319 Speaker 5: are doing in response is they're actually doing so called 170 00:09:13,400 --> 00:09:16,760 Speaker 5: outcomes trials trying to prove that if you give their 171 00:09:16,840 --> 00:09:19,520 Speaker 5: drugs to someone who's a bee that though, you'll reduce 172 00:09:19,559 --> 00:09:21,920 Speaker 5: the rate of heart attacks and strokes, or you'll prevent 173 00:09:22,040 --> 00:09:24,800 Speaker 5: complications of sleep apnea, or in someone who is abese 174 00:09:24,840 --> 00:09:27,559 Speaker 5: with heart failure, to prevent heart failure related events. So 175 00:09:27,600 --> 00:09:29,720 Speaker 5: they're trying to do that and those trials, which should 176 00:09:29,760 --> 00:09:32,240 Speaker 5: start reading out as soon as this summer, those are 177 00:09:32,240 --> 00:09:35,000 Speaker 5: going to be very, very important to determine what kind 178 00:09:35,040 --> 00:09:37,840 Speaker 5: of coverage that these drugs get over the long term. 179 00:09:38,040 --> 00:09:40,040 Speaker 3: And this kind of speaks to the bigger question of 180 00:09:40,160 --> 00:09:44,720 Speaker 3: like what is obesity? Is obesity inherently a disease? And 181 00:09:44,760 --> 00:09:48,440 Speaker 3: about a decade ago, the American Medical Association said, yeah, 182 00:09:48,520 --> 00:09:51,440 Speaker 3: obesity is a disease. And part of the reason they 183 00:09:51,480 --> 00:09:54,520 Speaker 3: did that is they wanted doctors to start diagnosing it, 184 00:09:54,559 --> 00:09:57,840 Speaker 3: they wanted health insurance to start paying for it. What's 185 00:09:57,880 --> 00:10:01,000 Speaker 3: interesting about that is if obesity is a disease, then 186 00:10:01,200 --> 00:10:04,800 Speaker 3: weight loss alone might be enough to make a difference 187 00:10:04,800 --> 00:10:09,000 Speaker 3: with this disease. You don't normally see a company having 188 00:10:09,040 --> 00:10:11,880 Speaker 3: to run more trials than just this sort of initial 189 00:10:11,880 --> 00:10:14,760 Speaker 3: trial to get coverage like this, Like this shows that 190 00:10:14,840 --> 00:10:17,559 Speaker 3: the bar for proving these drugs work. 191 00:10:17,760 --> 00:10:20,920 Speaker 4: Is higher, and question about why is it higher? 192 00:10:20,920 --> 00:10:23,040 Speaker 3: You know, I think some people would say this is stigma, 193 00:10:23,120 --> 00:10:25,720 Speaker 3: this is discrimination, But I think there is a really 194 00:10:25,760 --> 00:10:27,960 Speaker 3: interesting question at the heart of this of you know, 195 00:10:28,080 --> 00:10:31,360 Speaker 3: many many people in America are considered to have quote 196 00:10:31,440 --> 00:10:35,560 Speaker 3: unquote excess weight. But are all those people sick? Well, 197 00:10:35,559 --> 00:10:37,440 Speaker 3: we know a lot of them aren't, right. We know 198 00:10:37,640 --> 00:10:42,160 Speaker 3: many people with these higher BMIs don't necessarily have all 199 00:10:42,160 --> 00:10:45,719 Speaker 3: these other diseases, right, They don't necessarily have diabetes or 200 00:10:45,800 --> 00:10:49,760 Speaker 3: heart disease. And it gets into all these thorny, complicated, 201 00:10:50,040 --> 00:10:51,319 Speaker 3: difficult questions. 202 00:10:52,360 --> 00:10:55,079 Speaker 1: After the break, with so much demand for these drugs, 203 00:10:55,160 --> 00:11:07,240 Speaker 1: will the price start to come down? Emma, you report 204 00:11:07,240 --> 00:11:11,120 Speaker 1: that obesity can sometimes get in the way of doctor's 205 00:11:11,320 --> 00:11:15,480 Speaker 1: ability to treat people for serious illnesses. What did you find? 206 00:11:16,600 --> 00:11:19,559 Speaker 3: Something that is not super well known is that there 207 00:11:19,600 --> 00:11:25,040 Speaker 3: are body mass index limits, often for medical equipment. So 208 00:11:25,080 --> 00:11:27,880 Speaker 3: if you're trying to get certain kinds of scans you 209 00:11:27,960 --> 00:11:30,200 Speaker 3: might not be able to if you you know way 210 00:11:30,280 --> 00:11:35,679 Speaker 3: too much. There are also body mass index limits for procedures, 211 00:11:35,679 --> 00:11:39,360 Speaker 3: often and you know, ostensibly to make them less risky. 212 00:11:39,960 --> 00:11:43,480 Speaker 3: Carolina Povian, who's a obesity doctor at Brigham and Women's 213 00:11:43,520 --> 00:11:47,600 Speaker 3: Hospital in Boston, told us she has patients who because 214 00:11:47,640 --> 00:11:53,200 Speaker 3: of their body mass index, can't qualify for literally organ transplants. 215 00:11:53,360 --> 00:11:57,880 Speaker 3: We're talking heart transplants. People can't qualify for because of 216 00:11:57,920 --> 00:12:00,760 Speaker 3: their body mass index. And yet they they also can't 217 00:12:00,760 --> 00:12:03,520 Speaker 3: get access to a drug that would help them unless 218 00:12:03,520 --> 00:12:06,520 Speaker 3: they're quite wealthy or they work at a company with 219 00:12:06,600 --> 00:12:08,240 Speaker 3: exceptional insurance benefits. 220 00:12:08,679 --> 00:12:12,040 Speaker 5: There have been some big wins for the Coalition to 221 00:12:12,120 --> 00:12:15,120 Speaker 5: Doctors and advocates and companies are pushing for better coverage. 222 00:12:15,120 --> 00:12:18,280 Speaker 5: And one of the most concrete examples of improving coverage 223 00:12:18,320 --> 00:12:21,120 Speaker 5: is the Federal Employee Benefits Plan, and that's a big 224 00:12:21,360 --> 00:12:24,520 Speaker 5: cluster of plans that covers federal employees. We're talking eight 225 00:12:24,559 --> 00:12:27,080 Speaker 5: million people are in this. The federal government this year 226 00:12:27,120 --> 00:12:30,240 Speaker 5: put out a rule that is requiring insurers in that 227 00:12:30,360 --> 00:12:33,520 Speaker 5: plan to cover at least one of these GLP one 228 00:12:33,640 --> 00:12:36,280 Speaker 5: drugs for BC. That's a big change that adds a 229 00:12:36,280 --> 00:12:38,000 Speaker 5: lot of people onto the coverage roles. 230 00:12:38,440 --> 00:12:41,480 Speaker 3: We also found in our analysis of state medicaid plans, 231 00:12:41,520 --> 00:12:44,520 Speaker 3: So this is Medicaid is the program that ensures low 232 00:12:44,559 --> 00:12:46,880 Speaker 3: income individuals in the US, and it varies a lot 233 00:12:46,920 --> 00:12:47,720 Speaker 3: by state to state. 234 00:12:48,080 --> 00:12:50,440 Speaker 4: And what we found as part of this is policies 235 00:12:50,480 --> 00:12:51,080 Speaker 4: are changing. 236 00:12:51,120 --> 00:12:54,200 Speaker 3: So a couple of states have actually started covering obcit 237 00:12:54,320 --> 00:12:57,360 Speaker 3: drugs in recent years. A bunch of states, about eight 238 00:12:57,440 --> 00:13:00,400 Speaker 3: told us that they're actually looking at maybe covering So 239 00:13:00,800 --> 00:13:03,720 Speaker 3: it does seem like things are changing incrementally. 240 00:13:04,600 --> 00:13:08,280 Speaker 1: What did the drug companies say about why these drugs 241 00:13:08,280 --> 00:13:09,080 Speaker 1: are so expensive. 242 00:13:10,120 --> 00:13:12,120 Speaker 5: I've done a lot of reporting on drug pricing over 243 00:13:12,160 --> 00:13:14,360 Speaker 5: the years, and I found when you ask a company 244 00:13:14,400 --> 00:13:16,880 Speaker 5: you know about the price, it's very hard to get 245 00:13:16,880 --> 00:13:19,640 Speaker 5: a clear answer why they price it the way they do. 246 00:13:19,720 --> 00:13:22,040 Speaker 5: But you know what Eli Lilly and Novadora say is, 247 00:13:22,200 --> 00:13:25,480 Speaker 5: you know, the price of the drugs reflects the value 248 00:13:26,200 --> 00:13:29,720 Speaker 5: and clinical benefits that they provide. Now, I will note 249 00:13:29,720 --> 00:13:33,040 Speaker 5: that the Munjaro that's Eli Lilly's drug, is only approved 250 00:13:33,120 --> 00:13:35,640 Speaker 5: right now for a diabetes, So they're talking about diabetes. 251 00:13:36,040 --> 00:13:39,520 Speaker 5: And there's another strange aspect of the pricing that's going 252 00:13:39,559 --> 00:13:43,120 Speaker 5: on in that Novo Nordisk when it came out with 253 00:13:43,200 --> 00:13:45,560 Speaker 5: a higher dose version of a zempic called the GOVI 254 00:13:45,760 --> 00:13:49,040 Speaker 5: that's only approved for obesity, it decided to price it 255 00:13:49,080 --> 00:13:52,360 Speaker 5: about forty percent higher than ozempic, even though it's just 256 00:13:52,400 --> 00:13:55,000 Speaker 5: a modestly higher dose of exactly the same drug. 257 00:13:55,480 --> 00:13:56,760 Speaker 1: And why do they say they did that? 258 00:13:57,320 --> 00:13:59,800 Speaker 4: We asked Novo Nordisk about this. 259 00:14:00,320 --> 00:14:03,680 Speaker 3: Basically what they say is that with gov is more 260 00:14:03,679 --> 00:14:08,360 Speaker 3: effective than their previous weight loss drug called Sexenda. 261 00:14:08,920 --> 00:14:10,480 Speaker 4: You know, that's why they priced it that way. 262 00:14:10,960 --> 00:14:15,280 Speaker 3: One common answer as well, it's a higher dose than nozepic. 263 00:14:14,760 --> 00:14:17,000 Speaker 4: But it's not that much of a higher dose. 264 00:14:18,760 --> 00:14:21,280 Speaker 1: As you continue to cover this, what are you looking for? 265 00:14:21,320 --> 00:14:22,880 Speaker 1: What do you think comes next? 266 00:14:23,360 --> 00:14:26,280 Speaker 5: Well, I want to see will any of these other attempts, 267 00:14:26,360 --> 00:14:29,000 Speaker 5: you know, develop other follow on drugs, Will any of 268 00:14:29,000 --> 00:14:31,120 Speaker 5: them come to fruition, Like one of the things that 269 00:14:31,280 --> 00:14:33,560 Speaker 5: could help will be something that's not an injection that 270 00:14:33,600 --> 00:14:35,880 Speaker 5: could be taken as a pill on. You know, some 271 00:14:35,920 --> 00:14:38,000 Speaker 5: other drug companies like fives are working on but it's 272 00:14:38,320 --> 00:14:40,760 Speaker 5: not clear whether those are going to have as much efficacy. 273 00:14:41,000 --> 00:14:42,920 Speaker 5: So we'll get to know that in a few years. 274 00:14:43,480 --> 00:14:44,840 Speaker 3: I do think there's going to be a lot of 275 00:14:44,840 --> 00:14:48,080 Speaker 3: pressure to expand insurance coverage. I also think there's gonna 276 00:14:48,080 --> 00:14:49,920 Speaker 3: be a lot of resistance to paying for it. It 277 00:14:49,960 --> 00:14:52,600 Speaker 3: feels like things are going to come to a boil 278 00:14:52,680 --> 00:14:53,280 Speaker 3: pretty soon. 279 00:14:54,400 --> 00:14:56,880 Speaker 1: Emma, Bob, thanks so much for coming on the show. 280 00:14:57,440 --> 00:14:58,720 Speaker 4: Thank you, thank you. 281 00:14:59,400 --> 00:15:02,240 Speaker 1: When we come back, I talked to a physician about 282 00:15:02,240 --> 00:15:06,200 Speaker 1: these weight loss drugs and the challenges of treating obesity. 283 00:15:14,760 --> 00:15:18,480 Speaker 1: Let's hear now from someone who confronts these questions every day. 284 00:15:18,840 --> 00:15:23,160 Speaker 1: Doctor Angela Fitch specializes in the treatment of obesity. She's 285 00:15:23,280 --> 00:15:27,400 Speaker 1: president of the Obesity Medical Association, and I caught up 286 00:15:27,440 --> 00:15:31,680 Speaker 1: with her at the group's spring conference in New York City. Angela, 287 00:15:31,760 --> 00:15:37,400 Speaker 1: the American Medical Association ten years ago classified obesity as 288 00:15:37,600 --> 00:15:40,880 Speaker 1: a disease. What is the importance of this distinction? 289 00:15:41,880 --> 00:15:45,400 Speaker 2: So obesity really is a disease like other chronic diseases, 290 00:15:45,880 --> 00:15:49,320 Speaker 2: and the path of physiology behind it is much more 291 00:15:49,360 --> 00:15:53,920 Speaker 2: complicated than just the idea of eating less and moving more. Right, 292 00:15:53,920 --> 00:15:57,280 Speaker 2: there's a lot of diseases hypertension, high cholesterol, heart disease 293 00:15:57,800 --> 00:16:01,400 Speaker 2: that have lifestyle factors involved with them. But for many 294 00:16:01,480 --> 00:16:05,480 Speaker 2: years it was felt even by personally, by patients, by society, 295 00:16:05,840 --> 00:16:08,680 Speaker 2: that obesity was just people's fault, that it was just 296 00:16:08,720 --> 00:16:11,400 Speaker 2: their own responsibility, and that they were just eating too 297 00:16:11,480 --> 00:16:14,520 Speaker 2: much and not moving enough. And so this importance of 298 00:16:14,560 --> 00:16:17,080 Speaker 2: classifying it as a disease was that it really is 299 00:16:17,120 --> 00:16:20,280 Speaker 2: a disease because it's more complicated than just eating less 300 00:16:20,320 --> 00:16:23,640 Speaker 2: and moving more and the AMA you know, declaring it 301 00:16:23,680 --> 00:16:26,640 Speaker 2: a disease in twenty thirteen, you know, that's a long 302 00:16:26,680 --> 00:16:28,920 Speaker 2: time ago, but over the course of this time, I 303 00:16:28,960 --> 00:16:32,080 Speaker 2: really feel like we're finally at an awareness currently that 304 00:16:32,160 --> 00:16:34,120 Speaker 2: it is a disease. You know, I liken it to 305 00:16:34,160 --> 00:16:37,400 Speaker 2: mental health issues as well. For longest time, people didn't 306 00:16:37,400 --> 00:16:40,080 Speaker 2: think depression or anxiety or other types of mental health 307 00:16:40,080 --> 00:16:42,360 Speaker 2: issues was a disease state. It was more of just 308 00:16:42,440 --> 00:16:45,160 Speaker 2: a you know, the person's own issue that they're dealing with. 309 00:16:45,240 --> 00:16:47,720 Speaker 2: It was very stigmatizing, and now you know, we're at 310 00:16:47,760 --> 00:16:50,120 Speaker 2: a point where people are more accepting of it is 311 00:16:50,280 --> 00:16:53,080 Speaker 2: more about people's chemistry than about their character, right, This 312 00:16:53,200 --> 00:16:56,000 Speaker 2: is not a character law. This is a biochemical process 313 00:16:56,440 --> 00:16:58,920 Speaker 2: that creates the disease of obesity, just like you know, 314 00:16:58,920 --> 00:17:01,680 Speaker 2: similar to what was a struggle for mental health for 315 00:17:01,800 --> 00:17:04,399 Speaker 2: very many years until there was an increased awareness and 316 00:17:04,400 --> 00:17:08,160 Speaker 2: an increased focus on treating the disease in a comprehensive 317 00:17:08,240 --> 00:17:09,960 Speaker 2: chronic disease management fashion. 318 00:17:11,160 --> 00:17:15,360 Speaker 1: You mentioned treating the disease. How does classifying obesity as 319 00:17:15,359 --> 00:17:18,080 Speaker 1: a disease change the treatment? What are the practical effects 320 00:17:18,080 --> 00:17:18,320 Speaker 1: of that? 321 00:17:18,760 --> 00:17:22,320 Speaker 2: Yeah, because what we're leveraging for is better insurance coverage. 322 00:17:22,640 --> 00:17:27,000 Speaker 2: We're leveraging for coverage of the whole spectrum of the 323 00:17:27,119 --> 00:17:33,399 Speaker 2: disease process, from lifestyle management to medications, pharmacotherapy to bartic surgery, 324 00:17:33,400 --> 00:17:36,879 Speaker 2: which is a very comprehensive approach to the treatment of 325 00:17:36,920 --> 00:17:39,240 Speaker 2: a disease state. You know, much like cancer. You have 326 00:17:39,560 --> 00:17:43,080 Speaker 2: a surgery for cancer, you have chemotherapy, you have radiation treatment, 327 00:17:43,240 --> 00:17:45,639 Speaker 2: you have mental health treatment, you have lifestyle treatment that 328 00:17:45,680 --> 00:17:48,480 Speaker 2: affects cancer. You know, a lot of cancer centers offer 329 00:17:49,080 --> 00:17:51,880 Speaker 2: yoga and other types of mindfulness based treatment to help 330 00:17:51,920 --> 00:17:54,520 Speaker 2: their patients live a longer, healthier life. And a lot 331 00:17:54,600 --> 00:17:57,000 Speaker 2: of those times, those types of services can be covered 332 00:17:57,160 --> 00:18:01,359 Speaker 2: under certain plans or by employers because of the fact 333 00:18:01,359 --> 00:18:04,360 Speaker 2: that they are part of the overall comprehensive disease treatment. 334 00:18:04,720 --> 00:18:08,159 Speaker 2: So it's about gaining access for patients, you know, access 335 00:18:08,160 --> 00:18:11,040 Speaker 2: to coverage for these services by their insurance versus having 336 00:18:11,040 --> 00:18:14,600 Speaker 2: to pay for so long, obesity was something patients were 337 00:18:14,600 --> 00:18:16,840 Speaker 2: expected to pay out of pocket for in order to 338 00:18:16,880 --> 00:18:18,280 Speaker 2: get access to that care. 339 00:18:19,040 --> 00:18:23,040 Speaker 1: The treatment that we're talking about today are obesity drugs, 340 00:18:23,040 --> 00:18:26,240 Speaker 1: this new class of drug that seems to be very effective. 341 00:18:27,000 --> 00:18:30,200 Speaker 1: Are you using these drugs in your own practice? 342 00:18:30,640 --> 00:18:33,119 Speaker 2: Yes, I've been practicing obest medicine. Now. I was a 343 00:18:33,119 --> 00:18:36,840 Speaker 2: primary care physician double bordered in inter medicine and pediatric, 344 00:18:36,880 --> 00:18:39,440 Speaker 2: so I see the full spectrum of the disease from 345 00:18:40,119 --> 00:18:43,600 Speaker 2: young childhood, you know, through even older adulthood, so that 346 00:18:43,680 --> 00:18:47,680 Speaker 2: full spectrum of treatment. You know, we offer pharmacotherapy as 347 00:18:47,760 --> 00:18:50,880 Speaker 2: part of that treatment in the appropriate patient that it's 348 00:18:50,880 --> 00:18:54,919 Speaker 2: indicated for, because it is much more effective than lifestyle alone. 349 00:18:55,119 --> 00:18:56,800 Speaker 2: You know, a person with a blood pressure of one 350 00:18:56,880 --> 00:18:59,440 Speaker 2: hundred and eighty over one hundred in my office, you know, 351 00:18:59,480 --> 00:19:02,680 Speaker 2: I'm not going to just recommend lifestyle therey to start with, 352 00:19:03,000 --> 00:19:06,399 Speaker 2: because that person has a disease burden of hypertension that 353 00:19:06,520 --> 00:19:09,920 Speaker 2: is so strong for them, whether that's genetic or environmental, 354 00:19:10,119 --> 00:19:13,119 Speaker 2: or maybe they have one kidney because they lost one 355 00:19:13,160 --> 00:19:15,199 Speaker 2: in surgery. You know, the point is that they have 356 00:19:15,280 --> 00:19:18,040 Speaker 2: a disease state that's bothering them, and if we don't 357 00:19:18,040 --> 00:19:20,439 Speaker 2: treat it with a medication, they might have a stroke 358 00:19:20,560 --> 00:19:22,359 Speaker 2: or a heart attack or some other thing happen. 359 00:19:22,640 --> 00:19:23,360 Speaker 4: And the same is. 360 00:19:23,280 --> 00:19:25,800 Speaker 2: True as obesti as a disease. You know, this has 361 00:19:25,840 --> 00:19:28,840 Speaker 2: a lessyle component to it that is effective, but also 362 00:19:29,080 --> 00:19:32,639 Speaker 2: it's much more effective. We're talking ten times more effective 363 00:19:32,920 --> 00:19:35,879 Speaker 2: to reach your goals by adding pharmaco therapy, which is 364 00:19:36,000 --> 00:19:39,959 Speaker 2: very similar to other chronic diseases that we manage diabetes, hypertension, 365 00:19:40,000 --> 00:19:44,240 Speaker 2: cardiovath but disease, etc. Biologically, as humans, we are not 366 00:19:44,440 --> 00:19:47,560 Speaker 2: designed to lose weight. It goes against everything in mother 367 00:19:47,680 --> 00:19:50,199 Speaker 2: nature for us to lose weight. It's not the normal 368 00:19:50,240 --> 00:19:53,840 Speaker 2: process for us. So trying to alter mother nature takes 369 00:19:53,880 --> 00:19:56,800 Speaker 2: more than usually what we can sort of will away, 370 00:19:56,840 --> 00:19:57,359 Speaker 2: if you will. 371 00:19:59,040 --> 00:20:02,120 Speaker 1: What's been your exp eperiencing trying to get coverage for 372 00:20:02,280 --> 00:20:05,880 Speaker 1: patients you prescribe these drugs, so it is very variable. 373 00:20:05,880 --> 00:20:08,520 Speaker 2: I'm very fortunate that in New England where I'm practicing 374 00:20:08,600 --> 00:20:12,879 Speaker 2: right now, we have excellent coverage by our commercial payers. 375 00:20:13,080 --> 00:20:14,840 Speaker 2: So one of the things that we're trying to fix 376 00:20:14,880 --> 00:20:17,439 Speaker 2: here at the OBC Medicine Association for which I'm president 377 00:20:17,520 --> 00:20:20,919 Speaker 2: right now, is advocate that obese treatment would be a 378 00:20:20,960 --> 00:20:24,320 Speaker 2: standard benefit on the insurance plan right now, the problem 379 00:20:24,400 --> 00:20:27,080 Speaker 2: across the country and all commercial payers is that it's 380 00:20:27,119 --> 00:20:30,639 Speaker 2: not a standard benefit, so employers have to choose to 381 00:20:30,720 --> 00:20:35,680 Speaker 2: add it for an extra cost onto their coverage. Employers 382 00:20:35,680 --> 00:20:37,439 Speaker 2: sometimes don't do that, they don't know they have to 383 00:20:37,480 --> 00:20:39,439 Speaker 2: do it. Maybe there's a lot of reasons, you know, 384 00:20:39,560 --> 00:20:40,000 Speaker 2: for that. 385 00:20:40,800 --> 00:20:43,480 Speaker 1: In recent years, we've seen the rise of a body 386 00:20:43,520 --> 00:20:46,440 Speaker 1: positivity movement, which says that just because you have a 387 00:20:46,520 --> 00:20:48,960 Speaker 1: large body doesn't mean that you're sick. That there are 388 00:20:49,000 --> 00:20:52,720 Speaker 1: people who are obese under the clinical definition but lead 389 00:20:52,800 --> 00:20:56,080 Speaker 1: healthy lives, and there's people who are not clinically obese 390 00:20:56,119 --> 00:20:58,960 Speaker 1: who have diseases. What is your view on that. 391 00:21:00,320 --> 00:21:01,960 Speaker 2: I would say that one thing we're trying to work 392 00:21:02,000 --> 00:21:04,200 Speaker 2: on too is to get rid of the word obese 393 00:21:04,200 --> 00:21:07,919 Speaker 2: from our vocabulary, because what we talk about is obese 394 00:21:08,000 --> 00:21:10,240 Speaker 2: sort of defines a person by their disease, and we 395 00:21:10,280 --> 00:21:13,600 Speaker 2: don't like to use that terminology. And so when you 396 00:21:13,680 --> 00:21:15,840 Speaker 2: have the disease of obesity, it's a disease that you 397 00:21:15,920 --> 00:21:18,240 Speaker 2: have and you live with It's not something that sort 398 00:21:18,240 --> 00:21:21,280 Speaker 2: of defines you, like I am an obese person, right, 399 00:21:21,320 --> 00:21:25,000 Speaker 2: that sort of defines who I am versus I have obesity. 400 00:21:25,119 --> 00:21:27,720 Speaker 2: The disease, as you pointed out, not everybody has the 401 00:21:27,760 --> 00:21:30,919 Speaker 2: same severity of the disease is the issue. So what 402 00:21:30,960 --> 00:21:35,240 Speaker 2: we're really looking at is identifying what each individual person's 403 00:21:35,320 --> 00:21:37,760 Speaker 2: risk factor is related to that disease, like we do 404 00:21:37,840 --> 00:21:41,080 Speaker 2: with any disease state, and then deciding in an individual 405 00:21:41,160 --> 00:21:43,800 Speaker 2: shared decision making fashion between the patient and the clinician 406 00:21:44,280 --> 00:21:47,119 Speaker 2: if treatment is warranted for them at this time, because 407 00:21:47,119 --> 00:21:50,560 Speaker 2: even if they might be very healthy without other comorbidities, 408 00:21:50,680 --> 00:21:53,879 Speaker 2: their obesity may be preventing them from running around as 409 00:21:53,960 --> 00:21:56,920 Speaker 2: much at the playground with their grandchildren or fitting into 410 00:21:56,920 --> 00:21:59,040 Speaker 2: the airline seat when they're traveling a lot because that's 411 00:21:59,040 --> 00:22:01,919 Speaker 2: what they do for work. There's other reasons besides just 412 00:22:02,200 --> 00:22:06,080 Speaker 2: general health or metabolic health that people choose to make 413 00:22:06,160 --> 00:22:09,560 Speaker 2: changes to their weight, and they certainly should be accepted 414 00:22:09,600 --> 00:22:12,480 Speaker 2: no matter what size they are, so reducing the bias 415 00:22:12,520 --> 00:22:15,760 Speaker 2: and stigma around size is very important. At the same time, 416 00:22:15,760 --> 00:22:18,119 Speaker 2: if they want to change their size, they should have 417 00:22:18,200 --> 00:22:19,280 Speaker 2: the access to do that. 418 00:22:21,160 --> 00:22:24,879 Speaker 1: Is there a concern that if these drugs are so 419 00:22:24,960 --> 00:22:29,600 Speaker 1: widely available and are so effective that people will depend 420 00:22:29,680 --> 00:22:33,280 Speaker 1: on them instead of living a healthy lifestyle where they 421 00:22:33,280 --> 00:22:36,159 Speaker 1: eat well and they exercise, that this will become something 422 00:22:36,160 --> 00:22:40,119 Speaker 1: that actually exacerbates a problem instead of addressing the core cause. 423 00:22:40,880 --> 00:22:45,000 Speaker 2: We really are addressing the core cause with pharmacotherapy. Again, 424 00:22:45,080 --> 00:22:48,240 Speaker 2: to assume that the core cause is poor eating or 425 00:22:48,280 --> 00:22:51,959 Speaker 2: lack of physical activity is a biased assumption. Many people 426 00:22:52,040 --> 00:22:55,280 Speaker 2: living in larger bodies with obesity are very active. So 427 00:22:55,440 --> 00:22:58,440 Speaker 2: just assuming that someone has OBCs not active. I mean, 428 00:22:58,520 --> 00:23:01,800 Speaker 2: I have patients who the Boston Marathon recently, and I 429 00:23:01,840 --> 00:23:04,199 Speaker 2: didn't run the Boston Marathon. I can't do that, but 430 00:23:04,280 --> 00:23:06,360 Speaker 2: they can because that's what they do and they practice 431 00:23:06,400 --> 00:23:08,760 Speaker 2: for it. Right, And there's many people who eat a 432 00:23:08,840 --> 00:23:11,320 Speaker 2: very healthy lifestyle, and that's why it's a disease state. 433 00:23:11,680 --> 00:23:14,200 Speaker 2: You know, just like if you get cancer, right, it's 434 00:23:14,200 --> 00:23:16,200 Speaker 2: not your fault. It's not maybe something that you did, 435 00:23:16,200 --> 00:23:18,760 Speaker 2: maybe you didn't smoke, but at the same time you 436 00:23:18,880 --> 00:23:21,720 Speaker 2: ended up with lung cancer. Now that being said, we 437 00:23:21,840 --> 00:23:24,800 Speaker 2: all in the United States of America have to choose 438 00:23:24,880 --> 00:23:28,359 Speaker 2: to live differently than our current environment because our current 439 00:23:28,440 --> 00:23:32,720 Speaker 2: environment is very obesogenic. We have very large portion sizes, 440 00:23:32,840 --> 00:23:36,560 Speaker 2: we have more ultraprocessed food around us, we have less 441 00:23:36,560 --> 00:23:39,640 Speaker 2: physical activity. It's good for us to eat healthier, it's 442 00:23:39,680 --> 00:23:41,560 Speaker 2: good for us to eat more vegetables, to eat more 443 00:23:41,560 --> 00:23:44,199 Speaker 2: fiber and not eat the ultra processed food, right, but 444 00:23:44,280 --> 00:23:47,600 Speaker 2: it doesn't always treat the disease of obesity. So again 445 00:23:47,760 --> 00:23:51,119 Speaker 2: we need that comprehensive approach, and all of us at 446 00:23:51,119 --> 00:23:54,600 Speaker 2: the OBC Medicine Association that practice OBC medicine take a 447 00:23:54,640 --> 00:23:57,640 Speaker 2: comprehensive approach to treatment. You know, we're not just sort 448 00:23:57,680 --> 00:24:00,879 Speaker 2: of dolling out drugs, so to speak, talking about some 449 00:24:00,960 --> 00:24:03,960 Speaker 2: of these other lifestyle factors that are involved, because again 450 00:24:04,080 --> 00:24:07,880 Speaker 2: it's optimizing that whole patient journey. That is really what 451 00:24:07,960 --> 00:24:10,920 Speaker 2: all of us do as physicians and clinicians that practice 452 00:24:10,960 --> 00:24:13,760 Speaker 2: medicine every day, you know, with any issue that our 453 00:24:13,800 --> 00:24:16,919 Speaker 2: patients have, is to help them holistically, you know, to 454 00:24:16,960 --> 00:24:18,440 Speaker 2: reach their health and wellness goal. 455 00:24:19,359 --> 00:24:22,200 Speaker 1: Doctor Angela Fitch, thanks for speaking with me today. 456 00:24:22,760 --> 00:24:24,680 Speaker 2: Thank you so much, Bess as a pleasure. 457 00:24:25,160 --> 00:24:27,280 Speaker 1: Thanks for listening to us here at the Big Takes, 458 00:24:27,320 --> 00:24:30,920 Speaker 1: a daily podcast from Bloomberg and iHeartRadio for more shows 459 00:24:30,920 --> 00:24:34,720 Speaker 1: from my Heart Radio, visit the iHeartRadio app, Apple Podcasts, 460 00:24:34,800 --> 00:24:37,639 Speaker 1: or wherever you listen, and we'd love to hear from you. 461 00:24:37,720 --> 00:24:41,159 Speaker 1: Email us questions or comments to Big Take at Bloomberg 462 00:24:41,200 --> 00:24:45,040 Speaker 1: dot net. The supervising producer of The Big Take is 463 00:24:45,119 --> 00:24:49,920 Speaker 1: Vicky Vergalina. Our senior producer is Catherine Fink. Rebecca Shasson 464 00:24:50,080 --> 00:24:54,560 Speaker 1: is our producer. Our associate producer is Sam Gebauer. Raphael M. 465 00:24:54,600 --> 00:24:58,159 Speaker 1: Seely is our engineer. Our original music was composed by 466 00:24:58,240 --> 00:25:02,000 Speaker 1: Leo Sidrin. I'm Wescaso. We'll be back on Monday with 467 00:25:02,119 --> 00:25:04,360 Speaker 1: another Big Take. Have a great weekend. 468 00:25:05,560 --> 00:25:05,600 Speaker 3: M