1
00:00:01,120 --> 00:00:03,400
Speaker 1: Welcome to Stuff. You should know a production of My

2
00:00:03,600 --> 00:00:12,200
Speaker 1: Heart Radios How Stuff Works. Hey you, and welcome to

3
00:00:12,240 --> 00:00:15,600
Speaker 1: the podcast. I'm Josh Clark, and there's Charles W. Chuck

4
00:00:15,720 --> 00:00:20,439
Speaker 1: Bryan over there, and uh, I still know Jerry Chuck

5
00:00:20,480 --> 00:00:25,080
Speaker 1: wake up. Huh, We're gonna get some mail for that.

6
00:00:25,280 --> 00:00:29,880
Speaker 1: Right off of the bath, I feel quite refreshed. So, Chuck,

7
00:00:29,920 --> 00:00:32,839
Speaker 1: you might have an earcolepsy. Then if you just fell asleep,

8
00:00:32,920 --> 00:00:36,559
Speaker 1: were you able to resist that urge to sleep just now? No?

9
00:00:36,840 --> 00:00:39,240
Speaker 1: As soon as I heard, Hey, welcome to the podcast,

10
00:00:39,320 --> 00:00:42,680
Speaker 1: I went lights out. I think that happens to a

11
00:00:42,720 --> 00:00:46,600
Speaker 1: lot of people. Have you ever known anyone with narcolepsy?

12
00:00:47,520 --> 00:00:50,479
Speaker 1: I haven't. The closest I've I've come to that is

13
00:00:50,600 --> 00:00:56,720
Speaker 1: um watching my own private Idaho. What do you find that? Uh?

14
00:00:57,360 --> 00:01:02,120
Speaker 1: Sleep inducing? No? No, they is. I think it's remember

15
00:01:02,160 --> 00:01:05,360
Speaker 1: Phoenix or Keiana Reeves? Has I forgot about that? I

16
00:01:05,360 --> 00:01:09,800
Speaker 1: thought you were saying it so boring you can't stay awake? No? No, No,

17
00:01:10,000 --> 00:01:15,160
Speaker 1: that's Cats. Did you see that? No? Don't you remember that?

18
00:01:15,200 --> 00:01:17,279
Speaker 1: I tried to make myself go to sleep in Cats

19
00:01:17,280 --> 00:01:20,679
Speaker 1: in the Middle. Now I have not seen the movie. Now, yeah,

20
00:01:20,680 --> 00:01:23,360
Speaker 1: that's what I was wondering about. After having been on

21
00:01:23,440 --> 00:01:26,480
Speaker 1: movie crush, I'm now I can't tell what's what anymore.

22
00:01:26,520 --> 00:01:32,039
Speaker 1: What I said where? Uh So, my great aunt Laura

23
00:01:32,280 --> 00:01:38,000
Speaker 1: had narcolepsy, which is my paternal grandmother's sister, and uh

24
00:01:38,040 --> 00:01:39,840
Speaker 1: I only met her a few times. This is from

25
00:01:39,880 --> 00:01:43,319
Speaker 1: my my dad's side of the like the Mississippi clan.

26
00:01:43,760 --> 00:01:46,399
Speaker 1: So I think I only I only remember going to

27
00:01:46,440 --> 00:01:48,880
Speaker 1: Mississippi like once when I was a kid and visiting her,

28
00:01:49,280 --> 00:01:51,160
Speaker 1: and I just remember my brother and I. This is

29
00:01:51,200 --> 00:01:53,800
Speaker 1: my only memory of the visit is Scott and I

30
00:01:53,880 --> 00:01:57,160
Speaker 1: sitting in a room talking with her and her being

31
00:01:57,160 --> 00:01:59,720
Speaker 1: in the middle of a sentence and then her head

32
00:01:59,720 --> 00:02:03,520
Speaker 1: falling down and then ten seconds later she would pick

33
00:02:03,520 --> 00:02:07,040
Speaker 1: her head up and continue that sentence. Wow, like like

34
00:02:07,080 --> 00:02:09,919
Speaker 1: without missing a beat or was there like uh oh

35
00:02:10,000 --> 00:02:11,760
Speaker 1: you know that? Was she aware that she had just

36
00:02:11,800 --> 00:02:15,400
Speaker 1: fallen asleep and woken up. In my memory from being

37
00:02:15,440 --> 00:02:18,200
Speaker 1: like ten years old, she didn't miss a beat and

38
00:02:18,240 --> 00:02:20,280
Speaker 1: just finished her sentence like right in the middle of

39
00:02:20,320 --> 00:02:22,760
Speaker 1: a sentence and didn't mention it. And my brother and

40
00:02:22,800 --> 00:02:25,519
Speaker 1: I were just like, what is going on here? But

41
00:02:25,720 --> 00:02:28,680
Speaker 1: your dad didn't prepare you for it. I don't remember.

42
00:02:29,000 --> 00:02:31,800
Speaker 1: I blocked out, you know, purposely blocked out a lot

43
00:02:31,840 --> 00:02:35,240
Speaker 1: of my childhood right right, So I don't know, but

44
00:02:35,360 --> 00:02:38,960
Speaker 1: I hold it into the shuffle. That's the only thing

45
00:02:39,280 --> 00:02:41,920
Speaker 1: I remember it. It may be a child's memory that

46
00:02:42,080 --> 00:02:45,720
Speaker 1: is a little trumped up, but um, that's how I

47
00:02:45,760 --> 00:02:49,440
Speaker 1: remember it. Wow. Man, Well, yeah, I've never known anybody

48
00:02:49,440 --> 00:02:54,320
Speaker 1: with NARCILEPSI, and um, based on that going into this

49
00:02:54,360 --> 00:02:57,640
Speaker 1: whole episode, like I was just basically going in like

50
00:02:57,680 --> 00:02:59,840
Speaker 1: I'm sure most of our listeners are where it's just like, yeah,

51
00:03:00,120 --> 00:03:02,720
Speaker 1: somebody falls asleep in the middle of the day, they

52
00:03:02,760 --> 00:03:04,639
Speaker 1: can't help it, and then they wake back up, and

53
00:03:05,960 --> 00:03:09,320
Speaker 1: who cares basically, you know. But the more that I've

54
00:03:09,360 --> 00:03:12,359
Speaker 1: researched this some more, I'm like, you know, if it

55
00:03:12,560 --> 00:03:16,160
Speaker 1: even if it were just that alone, it would be

56
00:03:16,320 --> 00:03:19,480
Speaker 1: pretty disruptive to your normal life, depending on how often

57
00:03:19,480 --> 00:03:22,040
Speaker 1: it happened to you, you know, every day. But the

58
00:03:22,040 --> 00:03:25,400
Speaker 1: fact is it's not just that alone, and there's a

59
00:03:25,440 --> 00:03:28,320
Speaker 1: lot of extra symptoms to it that make it frightening

60
00:03:28,440 --> 00:03:31,919
Speaker 1: or terrifying or depressing or just completely disruptive or make

61
00:03:31,960 --> 00:03:34,920
Speaker 1: it so that you are, um, maybe unable to hold

62
00:03:34,920 --> 00:03:37,160
Speaker 1: down a job or go to school. There's a it's

63
00:03:37,200 --> 00:03:41,760
Speaker 1: actually a much um it's a much sadder condition than

64
00:03:41,800 --> 00:03:44,520
Speaker 1: I think most people think of because it seems innocuous.

65
00:03:44,520 --> 00:03:46,840
Speaker 1: It's just like, hey, you fall asleep here there, it's fine,

66
00:03:47,120 --> 00:03:48,920
Speaker 1: you know, and it's not. It's there's a lot more

67
00:03:48,960 --> 00:03:51,480
Speaker 1: to it than that. Yeah, for sure. UM. I should

68
00:03:51,480 --> 00:03:55,040
Speaker 1: also mention too that something that should not be confused

69
00:03:55,040 --> 00:03:59,720
Speaker 1: with narcolepsy is something that Emily's family has. Uh and

70
00:03:59,840 --> 00:04:01,440
Speaker 1: I saw this when we would go to visit when

71
00:04:01,440 --> 00:04:03,480
Speaker 1: they lived in Ohio, when he would stay at her

72
00:04:03,480 --> 00:04:09,080
Speaker 1: parents house. Well, you know, eating, drinking during the day,

73
00:04:09,320 --> 00:04:13,480
Speaker 1: such that by seven to eight o'clock at night every night,

74
00:04:13,680 --> 00:04:16,120
Speaker 1: I would Emily and I would look around, We're watching

75
00:04:16,120 --> 00:04:22,279
Speaker 1: TV and there are four usually three sleeping adults. And uh,

76
00:04:22,320 --> 00:04:24,560
Speaker 1: I dubbed it the gas leak, which everyone in their

77
00:04:24,600 --> 00:04:29,240
Speaker 1: family thought was hysterical. Right now, that's just play a

78
00:04:29,240 --> 00:04:32,480
Speaker 1: little funny. Yeah, that's that's not an earcalepsy at all.

79
00:04:32,520 --> 00:04:36,359
Speaker 1: That's just you know, at what age does that start happening?

80
00:04:36,480 --> 00:04:38,159
Speaker 1: Is what I want to know. Because I'm creeping up there,

81
00:04:40,200 --> 00:04:43,080
Speaker 1: because I can still jam late into the night. I'm

82
00:04:43,120 --> 00:04:45,880
Speaker 1: still you know, I might be sleepy the next day,

83
00:04:45,880 --> 00:04:49,479
Speaker 1: but that's my only time when I don't have a

84
00:04:49,520 --> 00:04:53,040
Speaker 1: five year old, so I used that time. I can

85
00:04:53,040 --> 00:04:55,320
Speaker 1: stay up still till midnight one in the morning. If

86
00:04:55,360 --> 00:04:58,320
Speaker 1: I am doing something that's really neat, you must have

87
00:04:58,360 --> 00:05:02,960
Speaker 1: a lot of testostero and left. I don't think so well.

88
00:05:03,000 --> 00:05:07,120
Speaker 1: I mean well, no, I mean, um like to have

89
00:05:07,440 --> 00:05:11,040
Speaker 1: energy after you know, a certain time of day is

90
00:05:11,520 --> 00:05:13,960
Speaker 1: I think I think you have a lot of test testerone, chuck,

91
00:05:14,000 --> 00:05:15,440
Speaker 1: I would bet we're going to take you in for

92
00:05:15,480 --> 00:05:18,920
Speaker 1: a test after this. Well, I feel like it. I

93
00:05:18,920 --> 00:05:22,360
Speaker 1: feel like it kicks back in. Like I'm sleepy sometimes

94
00:05:22,440 --> 00:05:24,440
Speaker 1: during the day, but then when the night comes and

95
00:05:24,520 --> 00:05:26,240
Speaker 1: my daughter's to sleep, I'm like, all right, this is

96
00:05:26,240 --> 00:05:28,920
Speaker 1: my this is my time to shine. No, that's very

97
00:05:28,960 --> 00:05:30,680
Speaker 1: fortunate man, that you're not just like this is my

98
00:05:30,800 --> 00:05:33,080
Speaker 1: time to netflix and chill like you're getting stuff done.

99
00:05:33,080 --> 00:05:34,960
Speaker 1: I'm envious of you for that because I get a

100
00:05:34,960 --> 00:05:37,560
Speaker 1: little tired. But I definitely don't have an ourcalepsy. I'm

101
00:05:37,600 --> 00:05:42,920
Speaker 1: just kind of like I'm somewhere between you and Emily's family.

102
00:05:44,120 --> 00:05:49,160
Speaker 1: They guess the correct yeah, so uh. An oarcilepsy is Uh,

103
00:05:49,440 --> 00:05:52,680
Speaker 1: it's a chronic disorder. It's a sleep disorder. And I

104
00:05:52,760 --> 00:05:54,960
Speaker 1: know we've talked a little bit about this in some

105
00:05:55,120 --> 00:05:58,200
Speaker 1: of our other sleep disorder episodes, UM, so much so

106
00:05:58,320 --> 00:06:00,040
Speaker 1: that I thought we might have actually covered this, but

107
00:06:00,120 --> 00:06:04,560
Speaker 1: a quadruple checked and we have not. But UM, it's

108
00:06:04,640 --> 00:06:06,840
Speaker 1: characterized by a few things. UM. One of the main

109
00:06:07,000 --> 00:06:11,159
Speaker 1: tenants that basically everybody that has an eclepsy has what's

110
00:06:11,160 --> 00:06:15,800
Speaker 1: called excessive daytime sleepiness. Right, that's what everybody thinks about

111
00:06:15,800 --> 00:06:18,159
Speaker 1: when you think of narclepsy. Somebody just falling asleep. They

112
00:06:18,200 --> 00:06:21,680
Speaker 1: can't help it, they're just suddenly out, that's right. Yeah.

113
00:06:21,760 --> 00:06:26,920
Speaker 1: They also call those, um sleep attacks. It's pretty cute. Um.

114
00:06:27,080 --> 00:06:30,840
Speaker 1: And no matter what variation of narcalepsy you have, you

115
00:06:31,040 --> 00:06:35,480
Speaker 1: have excessive daytime sleepiness E D yes, right, that's right.

116
00:06:35,800 --> 00:06:38,600
Speaker 1: And UM, this is not you know, this is nothing new.

117
00:06:38,680 --> 00:06:40,680
Speaker 1: We're just now sort of figuring it out a little

118
00:06:40,720 --> 00:06:43,920
Speaker 1: bit since the nineties, which we'll get to. But obviously

119
00:06:44,320 --> 00:06:47,800
Speaker 1: this has been happening since there have been people, uh

120
00:06:47,880 --> 00:06:50,680
Speaker 1: they they've probably been suffering from an eclepsy, you know,

121
00:06:50,720 --> 00:06:53,760
Speaker 1: a small percentage of people. But it was first described

122
00:06:54,120 --> 00:06:59,800
Speaker 1: in eight eight by a French physician named Jean Baptiste

123
00:07:00,320 --> 00:07:04,840
Speaker 1: Eduard Guilleneo. Not bad. How would you have said it,

124
00:07:05,560 --> 00:07:10,600
Speaker 1: Jean Baptiste dwar Jello? Is that is it a skip

125
00:07:10,720 --> 00:07:13,600
Speaker 1: to put that little uptick on the end? I think

126
00:07:13,640 --> 00:07:18,800
Speaker 1: that's called an exit agu right right, So yeah, that's

127
00:07:18,840 --> 00:07:20,280
Speaker 1: how I would have said it. But either way, I

128
00:07:20,360 --> 00:07:22,240
Speaker 1: think we we basically got it across. He was a

129
00:07:22,320 --> 00:07:26,520
Speaker 1: French physician from eighteen eighty that's the part. Yeah. And

130
00:07:26,640 --> 00:07:30,520
Speaker 1: the origin of the actual term is from Greek narca,

131
00:07:31,080 --> 00:07:33,400
Speaker 1: which is numbness or stupor. Stupor is one of my

132
00:07:33,440 --> 00:07:38,360
Speaker 1: favorite words, and leipsis to attack or two seize, right,

133
00:07:38,440 --> 00:07:42,240
Speaker 1: So it's an attack of stupor basically is what they

134
00:07:42,800 --> 00:07:45,800
Speaker 1: what he meant when he coined that term. And um,

135
00:07:46,240 --> 00:07:50,600
Speaker 1: the reason Jean Baptiste dead Ward Jello came up with

136
00:07:50,760 --> 00:07:54,640
Speaker 1: this is because the thirty six year old wine castmaker

137
00:07:54,720 --> 00:07:57,120
Speaker 1: came to him and said, Hey, I think there might

138
00:07:57,160 --> 00:08:00,880
Speaker 1: be something wrong with me. I follow as suddenly out

139
00:08:00,920 --> 00:08:04,640
Speaker 1: of nowhere for one to five minutes, two hundred times

140
00:08:04,800 --> 00:08:09,800
Speaker 1: a day every day. What do you think, Jelano said,

141
00:08:10,000 --> 00:08:12,040
Speaker 1: I think I'm gonna make my career on you. Buddy,

142
00:08:12,680 --> 00:08:15,720
Speaker 1: I did the math there. If you average about two

143
00:08:15,760 --> 00:08:17,800
Speaker 1: and a half minutes between the one to five, that's

144
00:08:17,800 --> 00:08:21,920
Speaker 1: about eight hours of dozing. Okay. I'm really glad you

145
00:08:22,000 --> 00:08:24,400
Speaker 1: said that, Chuck, because this was something that I had

146
00:08:24,680 --> 00:08:28,640
Speaker 1: no idea about. But if you take over a twenty

147
00:08:28,680 --> 00:08:33,040
Speaker 1: four hour period somebody with narcolepsy and put their amount

148
00:08:33,080 --> 00:08:37,760
Speaker 1: of sleep next to somebody without an ourcalepsy over twenty

149
00:08:37,840 --> 00:08:40,679
Speaker 1: four hours, it's gonna wash out roughly the same. Did

150
00:08:40,760 --> 00:08:43,199
Speaker 1: you know that. I didn't know that. But does that

151
00:08:43,320 --> 00:08:46,400
Speaker 1: mean that this guy dozed eight hours a day and

152
00:08:46,520 --> 00:08:48,720
Speaker 1: then stayed up all night or did he sleep another

153
00:08:49,040 --> 00:08:51,800
Speaker 1: five hours at night and just slept a lot. No.

154
00:08:52,400 --> 00:08:54,920
Speaker 1: So that's one of the one of the key reasons

155
00:08:55,080 --> 00:08:57,920
Speaker 1: that there is such thing as excessive daytime sleepiness as

156
00:08:57,960 --> 00:09:01,199
Speaker 1: part of narcolepsy. It's that your sleep is so disrupted

157
00:09:01,679 --> 00:09:04,640
Speaker 1: that it's basically spread out over twenty four hours rather

158
00:09:04,720 --> 00:09:08,520
Speaker 1: than concentrated over you know, eight hours at night. So

159
00:09:08,679 --> 00:09:11,120
Speaker 1: they're up and awake in the middle of the night

160
00:09:11,240 --> 00:09:14,600
Speaker 1: for very long periods, just like they fall asleep suddenly

161
00:09:14,760 --> 00:09:17,040
Speaker 1: during the day. But if you put all those bouts

162
00:09:17,080 --> 00:09:20,000
Speaker 1: of sleep together, even when they're trying at night, and

163
00:09:20,080 --> 00:09:22,040
Speaker 1: then when they can't help it during the day, it

164
00:09:22,120 --> 00:09:25,240
Speaker 1: adds up to about the same that a person without

165
00:09:25,720 --> 00:09:30,360
Speaker 1: narcolepsy will sleep. That's my understanding. Now, that's pretty remarkable.

166
00:09:31,720 --> 00:09:34,719
Speaker 1: Like the brains like, I'm getting sleep, whether whether you

167
00:09:34,840 --> 00:09:38,200
Speaker 1: like it or not, we're making this happen. At least

168
00:09:38,240 --> 00:09:41,760
Speaker 1: by twenty four hours, we're gonna have had enough. Uh.

169
00:09:41,880 --> 00:09:44,360
Speaker 1: And of course, you know, since this has been you know,

170
00:09:44,400 --> 00:09:46,280
Speaker 1: we're talking about the eighties, there's been a lot of

171
00:09:46,320 --> 00:09:50,319
Speaker 1: explanations over the years, everyone from Freud to you know,

172
00:09:50,920 --> 00:09:53,319
Speaker 1: it's about say, legitimate doctors that probably would have been

173
00:09:53,400 --> 00:09:56,280
Speaker 1: certain people like Freud. I like Freud too, but I

174
00:09:56,360 --> 00:10:02,160
Speaker 1: meant like, you know, um, never mind. Sure. But Freud

175
00:10:02,280 --> 00:10:06,440
Speaker 1: of course said that sleep is an escape, and he said,

176
00:10:06,679 --> 00:10:09,040
Speaker 1: you know, narcolepsy is a lot of times triggered by

177
00:10:09,520 --> 00:10:13,120
Speaker 1: really intense emotions. So here's what I think. It's just

178
00:10:13,320 --> 00:10:17,320
Speaker 1: an extreme defense mechanism that lets you escape from those emotions.

179
00:10:17,960 --> 00:10:22,560
Speaker 1: I love it. It's pretty Freudian. It's about as Freudian

180
00:10:22,600 --> 00:10:25,800
Speaker 1: an explanation for anything as I've heard. It's just classic right,

181
00:10:26,120 --> 00:10:30,319
Speaker 1: of course, it's just utterly wrong. But I love. I

182
00:10:30,440 --> 00:10:33,400
Speaker 1: just think Freud's attempts at explaining the world were great,

183
00:10:33,559 --> 00:10:38,800
Speaker 1: invaluable in the way that like preserving classic art is. Yeah,

184
00:10:38,880 --> 00:10:43,760
Speaker 1: I've been to his house. What where in Texas now? Yeah,

185
00:10:43,840 --> 00:10:47,720
Speaker 1: the Sigmund Freud house and in uh Tyler, Texas. There

186
00:10:47,760 --> 00:10:49,760
Speaker 1: are a lot of Germans in Texas. Although I know

187
00:10:49,880 --> 00:10:52,360
Speaker 1: he was Austrian. Yeah, I mean I believe I saw

188
00:10:52,400 --> 00:10:55,160
Speaker 1: it in Vienna if I'm not mistaken. That's neat, that

189
00:10:55,400 --> 00:10:58,400
Speaker 1: is very neat. Was this when you're backpacking? Yeah, of

190
00:10:58,520 --> 00:11:00,800
Speaker 1: course you need to do him. M are of that

191
00:11:01,040 --> 00:11:08,000
Speaker 1: time in your life and call it backpacking to Freud's house. Okay, okay,

192
00:11:08,440 --> 00:11:10,560
Speaker 1: so in the book could just be shaped like a penis.

193
00:11:12,320 --> 00:11:15,319
Speaker 1: Sometimes a book is just a book, that's right. So

194
00:11:15,559 --> 00:11:17,920
Speaker 1: Freud missed the mark a little bit, but still again

195
00:11:18,000 --> 00:11:22,319
Speaker 1: it's worth mentioning, just like appreciating art. It wasn't until

196
00:11:22,360 --> 00:11:25,240
Speaker 1: the sixties where they're like, okay, I think we're starting

197
00:11:25,280 --> 00:11:27,520
Speaker 1: to get some real clues here. And that was when

198
00:11:27,640 --> 00:11:33,280
Speaker 1: they first established that people with narcilepsy enter r e

199
00:11:33,559 --> 00:11:37,440
Speaker 1: M sleep during these bouts of narcalepsy, which you are

200
00:11:37,480 --> 00:11:41,120
Speaker 1: not supposed to do under normal sleep. Patterns which we

201
00:11:41,200 --> 00:11:43,720
Speaker 1: talked about many many times before. Like you said, when

202
00:11:43,800 --> 00:11:46,600
Speaker 1: you fall asleep, it should take you a little while

203
00:11:46,679 --> 00:11:49,280
Speaker 1: to enter R E M sleep. That's a deeper phase

204
00:11:49,400 --> 00:11:53,800
Speaker 1: of your sleep pattern. Right with with um narcilepsy, they're

205
00:11:53,880 --> 00:11:57,520
Speaker 1: out and into R E M sleep so quickly. That

206
00:11:57,640 --> 00:12:00,960
Speaker 1: A different way to characterize it that that ECLEPSI researchers

207
00:12:01,000 --> 00:12:05,559
Speaker 1: put it is that R E M activity it intrudes

208
00:12:05,640 --> 00:12:10,760
Speaker 1: into wakefulness. The line between being awake and being in

209
00:12:10,920 --> 00:12:14,000
Speaker 1: deep R E M sleep is that blurred for people

210
00:12:14,040 --> 00:12:18,599
Speaker 1: with narcolepsy. Yeah, And I feel like I've occasionally, in

211
00:12:18,679 --> 00:12:22,840
Speaker 1: a really intense power nap had a dream, but that's

212
00:12:22,880 --> 00:12:25,240
Speaker 1: only when it's and I don't get to nap anymore.

213
00:12:25,320 --> 00:12:28,240
Speaker 1: But that's when I've just been so tired that I

214
00:12:28,360 --> 00:12:31,920
Speaker 1: just napped and fall asleep like immediately. That's neat. I

215
00:12:32,040 --> 00:12:33,960
Speaker 1: bet you do you feel refreshed when you wake up?

216
00:12:34,960 --> 00:12:37,760
Speaker 1: M hmm. I tend to nap longer when I would nap,

217
00:12:37,880 --> 00:12:40,520
Speaker 1: so I wouldn't do the When I say power nap,

218
00:12:40,600 --> 00:12:42,480
Speaker 1: I don't mean the twenty minute disco nap. I mean

219
00:12:42,800 --> 00:12:45,640
Speaker 1: you really power power through for a couple of hours, right,

220
00:12:46,120 --> 00:12:48,600
Speaker 1: I thought you were recounting some of your cocaine using

221
00:12:48,679 --> 00:12:51,959
Speaker 1: days no, no, no, I got you. So that was

222
00:12:52,040 --> 00:12:54,160
Speaker 1: in the sixties. So they say, okay, R E M

223
00:12:54,280 --> 00:12:57,520
Speaker 1: and and uh narc eilepsy they go together like chocolate

224
00:12:57,559 --> 00:13:00,959
Speaker 1: and peanut butter. Right, we're onto something here. But finally

225
00:13:01,040 --> 00:13:04,520
Speaker 1: in the nineties they're like really have started to figure

226
00:13:04,559 --> 00:13:07,679
Speaker 1: it out, and they've zeroed in on the hypothalamus and

227
00:13:07,760 --> 00:13:11,240
Speaker 1: specifically a small cluster of cells in the rear of

228
00:13:11,280 --> 00:13:14,559
Speaker 1: the hypothalamus that we'll talk about later. And if you

229
00:13:15,600 --> 00:13:18,679
Speaker 1: learn about that and as far as narcolepsy goes, you

230
00:13:18,880 --> 00:13:21,440
Speaker 1: can find it pretty convincing that we have begun at

231
00:13:21,520 --> 00:13:25,560
Speaker 1: least to finally truly understand the cause of narcolepsy. Yeah,

232
00:13:25,640 --> 00:13:29,319
Speaker 1: I totally agree. It's they make a great case. So

233
00:13:29,520 --> 00:13:32,599
Speaker 1: if you want to talk to some initial stats. It

234
00:13:32,679 --> 00:13:36,360
Speaker 1: occurs in all ethnic groups. Uh, it has equal incidence

235
00:13:36,720 --> 00:13:41,880
Speaker 1: uh on the gender spectrum. Evidently. Yeah, that's interesting. And yeah,

236
00:13:41,880 --> 00:13:44,360
Speaker 1: because usually you would see it tilted one way or

237
00:13:44,400 --> 00:13:48,480
Speaker 1: the other. Yeah, for sure. Um. And then as far

238
00:13:48,559 --> 00:13:51,640
Speaker 1: as how often you're going to see this, it's in

239
00:13:51,720 --> 00:13:55,640
Speaker 1: about point oh three to point one six percent of

240
00:13:55,800 --> 00:13:59,360
Speaker 1: gin pop or about one and two thousand people. Yeah,

241
00:13:59,440 --> 00:14:02,840
Speaker 1: which makes it which classifies it as a rare disease, which,

242
00:14:02,920 --> 00:14:06,640
Speaker 1: by the way, shout out to, among several others, Rare

243
00:14:06,720 --> 00:14:11,000
Speaker 1: Diseases dot Org for their take on narcalypsy. It was

244
00:14:11,120 --> 00:14:16,199
Speaker 1: very instructive. Is it a disease or a disorder? Geez?

245
00:14:16,320 --> 00:14:20,760
Speaker 1: I think because there's a um a brain dysfunction, that

246
00:14:20,920 --> 00:14:23,960
Speaker 1: it would be characterized as a disease, wouldn't you. I

247
00:14:24,000 --> 00:14:25,840
Speaker 1: don't know. I still don't know the difference after all

248
00:14:25,880 --> 00:14:28,760
Speaker 1: these years. So it was I mean, when it was

249
00:14:29,120 --> 00:14:32,320
Speaker 1: considered an R. E. M. Sleep disorder and maybe it's

250
00:14:32,320 --> 00:14:35,280
Speaker 1: still is. It was considered a paras omnia like sleep

251
00:14:35,320 --> 00:14:37,360
Speaker 1: walking or whatever, So that would have been considered a

252
00:14:37,480 --> 00:14:42,280
Speaker 1: disorder them. But I think it's a disease. Now, Okay, Okay,

253
00:14:42,920 --> 00:14:44,240
Speaker 1: you want to take a break and come back and

254
00:14:44,320 --> 00:15:18,360
Speaker 1: talk about what anarcalypsy is. Okay, we'll be right back. Everybody. Okay,

255
00:15:18,400 --> 00:15:21,600
Speaker 1: we're back. And it turns out, Chuck, that there are

256
00:15:21,800 --> 00:15:25,120
Speaker 1: two types of narcilepsy, And just from all of the

257
00:15:25,200 --> 00:15:28,720
Speaker 1: research that we've done over the years on interesting health stuff,

258
00:15:29,640 --> 00:15:32,280
Speaker 1: this smells a lot to me like something that's going

259
00:15:32,360 --> 00:15:35,760
Speaker 1: to be broken out into its own thing over time. Yeah,

260
00:15:35,920 --> 00:15:39,440
Speaker 1: I agree, because we've seen that happen time and time again. Um.

261
00:15:39,600 --> 00:15:42,800
Speaker 1: We have narcilepsy type two, which is what we were

262
00:15:42,840 --> 00:15:45,080
Speaker 1: talking about, the sort of the more like when you

263
00:15:45,160 --> 00:15:47,760
Speaker 1: think of n earcilepsy, this is probably what you're thinking

264
00:15:47,840 --> 00:15:52,440
Speaker 1: of Aunt Laura falling asleep during the middle of a sentence, right.

265
00:15:52,920 --> 00:15:56,800
Speaker 1: And it's type two because it's um by far less

266
00:15:56,880 --> 00:16:01,720
Speaker 1: prevalent than type one. And type one is narcolepsy like

267
00:16:01,840 --> 00:16:06,520
Speaker 1: you'd think of with the daytime excessive daytime sleepiness. But

268
00:16:06,640 --> 00:16:09,800
Speaker 1: on top of that, there's something called cataplexy too. And

269
00:16:09,920 --> 00:16:13,720
Speaker 1: cataplexy can exist on its own. It's the just sudden

270
00:16:13,840 --> 00:16:16,840
Speaker 1: loss of voluntary muscle function, like you can't keep your

271
00:16:16,840 --> 00:16:19,840
Speaker 1: head up because your neck muscles just went limp, or

272
00:16:19,960 --> 00:16:23,920
Speaker 1: your arms go limp or something like that. And cataplexy

273
00:16:24,000 --> 00:16:26,880
Speaker 1: can exist on its own. It can exist in conjunction

274
00:16:26,960 --> 00:16:30,920
Speaker 1: with other diseases to or disorders. Um, but it very

275
00:16:31,040 --> 00:16:35,880
Speaker 1: frequently coexists with narcolepsy. And one of the hallmarks of

276
00:16:35,960 --> 00:16:38,280
Speaker 1: it from what I understand, because it gets it gets

277
00:16:38,360 --> 00:16:42,160
Speaker 1: kind of confusing and I couldn't fully find this out, Chuck,

278
00:16:42,720 --> 00:16:47,480
Speaker 1: but I I think that it can exist in a

279
00:16:47,640 --> 00:16:52,600
Speaker 1: person with narcolepsy in conjunction with a sleep attack or

280
00:16:52,800 --> 00:16:56,600
Speaker 1: separately to where you just suddenly like can't hold your

281
00:16:56,600 --> 00:17:00,120
Speaker 1: head up anymore. The key is you're still conscious. Just

282
00:17:00,560 --> 00:17:04,000
Speaker 1: oh my god, I just turned into an illiterate seventh grader.

283
00:17:05,119 --> 00:17:08,680
Speaker 1: You're still conscious. You just you might look like you

284
00:17:08,800 --> 00:17:10,960
Speaker 1: have just fainted or something like that, depending on the

285
00:17:11,320 --> 00:17:14,480
Speaker 1: severity of the cataplexic attack. Yeah, it's almost like a

286
00:17:14,560 --> 00:17:19,040
Speaker 1: fainting goat, right, Yes, very much like that, Almost exactly

287
00:17:19,119 --> 00:17:22,480
Speaker 1: like that, because remember with the feinting goats, they would

288
00:17:23,040 --> 00:17:26,320
Speaker 1: basically just fall over because they were startled. I think

289
00:17:26,400 --> 00:17:28,800
Speaker 1: pretty much the same thing with catoplexy and humans, although

290
00:17:28,840 --> 00:17:31,640
Speaker 1: it seems to be more associated with positive emotions. Yeah,

291
00:17:31,680 --> 00:17:34,359
Speaker 1: it's so interesting. Um yeah, we're gonna get into that.

292
00:17:34,480 --> 00:17:38,639
Speaker 1: There are four symptoms of narcolepsy, which we're going to

293
00:17:38,720 --> 00:17:42,760
Speaker 1: break down in a second. But they are excessive daytime

294
00:17:42,760 --> 00:17:47,360
Speaker 1: sleepiness like we've talked about. There is the cataplexy, their

295
00:17:47,400 --> 00:17:54,840
Speaker 1: sleep sleep paralysis, and then hipnagogic hallucinations and um, if

296
00:17:54,920 --> 00:18:00,440
Speaker 1: you have narcolepsy, you well there's about ants that you

297
00:18:00,520 --> 00:18:03,640
Speaker 1: have all four and I don't think there's any rhyme

298
00:18:03,680 --> 00:18:07,920
Speaker 1: or reason which ones you do have. But like we said,

299
00:18:08,080 --> 00:18:11,920
Speaker 1: everybody has the excessive daytime sleepiness. And they're also talking

300
00:18:11,960 --> 00:18:17,240
Speaker 1: about a fifth beatle. I was gonna say that Clarence

301
00:18:17,320 --> 00:18:20,800
Speaker 1: was that his name? Yeah? Or a Pooh said he

302
00:18:21,040 --> 00:18:26,000
Speaker 1: was too. The fifth symptom, which is disturbed nocturnal sleep,

303
00:18:26,800 --> 00:18:29,520
Speaker 1: which about of the patients have, but they haven't. I

304
00:18:29,600 --> 00:18:31,560
Speaker 1: think that'll end up in there at some point. And

305
00:18:31,760 --> 00:18:34,720
Speaker 1: technically there may be a sixth one to um, which

306
00:18:34,800 --> 00:18:37,560
Speaker 1: is called automatic behavior. Where have you ever been like

307
00:18:37,720 --> 00:18:41,600
Speaker 1: driving and you're suddenly like five exits further than you

308
00:18:41,680 --> 00:18:44,280
Speaker 1: thought you were, and you realize you just zoned out

309
00:18:44,320 --> 00:18:47,000
Speaker 1: and we're just driving just fine, but you were, You're

310
00:18:47,160 --> 00:18:51,040
Speaker 1: you're basically on autopilot. I don't know. I mean, is

311
00:18:51,080 --> 00:18:54,680
Speaker 1: that like the same as just daydreaming or maybe I

312
00:18:54,760 --> 00:18:57,800
Speaker 1: think so. But there's like no recollection of anything. You

313
00:18:57,880 --> 00:19:00,520
Speaker 1: didn't note any landmarks that you just pa uster. Let's

314
00:19:00,520 --> 00:19:02,800
Speaker 1: say you're gardening or something like that, you don't you

315
00:19:02,880 --> 00:19:06,320
Speaker 1: don't remember finishing digging the hole with a trowel. It's

316
00:19:06,480 --> 00:19:10,080
Speaker 1: it's you've just completed a task that you have no

317
00:19:10,359 --> 00:19:15,040
Speaker 1: memory of. Of undertaking. I don't think that happens. Okay,

318
00:19:15,160 --> 00:19:17,720
Speaker 1: so that's what's happened to me before. But that's a

319
00:19:17,880 --> 00:19:21,359
Speaker 1: symptom of of UM. It's an additional symptom. It's not

320
00:19:21,400 --> 00:19:23,399
Speaker 1: a classic symptom, but they're starting to figure out that

321
00:19:23,440 --> 00:19:26,040
Speaker 1: it does. It is a symptom of narcolepsy. Yes, so

322
00:19:26,160 --> 00:19:27,879
Speaker 1: you're like, I just I went in my garage one

323
00:19:27,920 --> 00:19:31,919
Speaker 1: day and I had built a penny farthing. No memory

324
00:19:31,960 --> 00:19:35,080
Speaker 1: of that how it got there. So it usually starts

325
00:19:35,119 --> 00:19:39,240
Speaker 1: out in adolescence, which surprised me. I did not know that,

326
00:19:40,200 --> 00:19:43,159
Speaker 1: just maybe because my Laura characterized it as something you

327
00:19:43,320 --> 00:19:46,520
Speaker 1: got later in life. But they do worsen with age,

328
00:19:46,560 --> 00:19:49,800
Speaker 1: so maybe that does make sense after all. And sometimes

329
00:19:49,920 --> 00:19:53,080
Speaker 1: your symptoms can be very steady. Sometimes it can be

330
00:19:53,320 --> 00:19:56,880
Speaker 1: months or years in between changes, and sometimes the symptoms

331
00:19:57,000 --> 00:20:01,119
Speaker 1: change a lot too very quickly. Right, um. But the

332
00:20:01,359 --> 00:20:04,800
Speaker 1: symptom that, again a hundred percent of UM people with

333
00:20:04,960 --> 00:20:09,240
Speaker 1: narcilepsy have is excessive daytime sleepiness. And in almost every

334
00:20:09,359 --> 00:20:13,360
Speaker 1: case of narcolepsy, that is the first symptom that starts.

335
00:20:13,800 --> 00:20:15,760
Speaker 1: You almost never start with the other ones. It's that

336
00:20:15,880 --> 00:20:19,320
Speaker 1: one first, And that's exactly what you think of where

337
00:20:19,640 --> 00:20:23,200
Speaker 1: somebody just falls asleep and they're out for a few

338
00:20:23,280 --> 00:20:26,320
Speaker 1: seconds to a few minutes, depending And it's not going

339
00:20:26,359 --> 00:20:28,840
Speaker 1: to be the same amount of time every time. They're

340
00:20:28,880 --> 00:20:31,600
Speaker 1: not going to have the same number of sleep attacks

341
00:20:31,680 --> 00:20:33,879
Speaker 1: every time. A lot of it has to do with

342
00:20:34,040 --> 00:20:37,000
Speaker 1: just how tired they are, like how poorly they slept

343
00:20:37,040 --> 00:20:39,600
Speaker 1: the night before. That's going to make them more susceptible

344
00:20:39,640 --> 00:20:42,000
Speaker 1: to sleep attacks during the day. And this is not

345
00:20:42,280 --> 00:20:45,800
Speaker 1: the same as hitting the wall at three o'clock because

346
00:20:45,840 --> 00:20:47,680
Speaker 1: you ate lunch and all of your coffee from the

347
00:20:47,760 --> 00:20:50,920
Speaker 1: morning war off. I mean, it bears some resemblance to it,

348
00:20:51,040 --> 00:20:56,000
Speaker 1: but this is it is irresistible. Um, this urge to

349
00:20:56,119 --> 00:20:59,360
Speaker 1: sleep or just sleep, it just comes on. So that's

350
00:20:59,520 --> 00:21:03,560
Speaker 1: that's a that's the main characteristic of an ecalepsy. But

351
00:21:03,880 --> 00:21:06,320
Speaker 1: anybody who's kind of dozed off, like sitting in a

352
00:21:06,400 --> 00:21:09,159
Speaker 1: comfortable chair when it was you know, a little warmer

353
00:21:09,240 --> 00:21:11,680
Speaker 1: than normal at work or something like that, right like

354
00:21:12,160 --> 00:21:14,800
Speaker 1: that is a it's it bears a resemblance to that

355
00:21:15,040 --> 00:21:18,800
Speaker 1: specific symptom of narcolepsy. It's the other ones that you

356
00:21:18,920 --> 00:21:21,600
Speaker 1: have in conjunction with that that really make an ecolepsy

357
00:21:21,720 --> 00:21:26,480
Speaker 1: like its own disorder. Have you ever slept at any

358
00:21:26,640 --> 00:21:33,800
Speaker 1: job you've ever had? It doesn't sound like me, but

359
00:21:34,000 --> 00:21:38,480
Speaker 1: probably I'm sure. I'm sure I have you know here there?

360
00:21:38,560 --> 00:21:41,600
Speaker 1: Why you well? I mean when I worked the midnight

361
00:21:41,680 --> 00:21:44,120
Speaker 1: to seven am shift at the Golden Pantry and Athens,

362
00:21:44,320 --> 00:21:49,000
Speaker 1: I had a regular routine of sleeping. Yeah, because you're

363
00:21:49,000 --> 00:21:50,800
Speaker 1: allowed to close up the store and mop and do

364
00:21:50,920 --> 00:21:53,520
Speaker 1: things for like an hour. So I would close up

365
00:21:53,520 --> 00:21:56,520
Speaker 1: the store, go back in the back, and uh, lay

366
00:21:56,560 --> 00:21:59,160
Speaker 1: down on a a little palette I made on top

367
00:21:59,200 --> 00:22:03,520
Speaker 1: of a free r n. Did you get some good sleep?

368
00:22:04,280 --> 00:22:06,760
Speaker 1: I would? It was pretty hard sleep, and I will

369
00:22:06,800 --> 00:22:11,680
Speaker 1: admit that. Uh. When I had a baby, I took

370
00:22:11,760 --> 00:22:14,600
Speaker 1: a nap or two right here in our own office.

371
00:22:15,200 --> 00:22:17,840
Speaker 1: Oh nice, what can you tell me? Where is it

372
00:22:17,920 --> 00:22:21,800
Speaker 1: still a secret? In one of the private telephone rooms. Oh,

373
00:22:21,960 --> 00:22:23,560
Speaker 1: that would be a good place to take a nap,

374
00:22:24,119 --> 00:22:25,800
Speaker 1: if you've ever gone in there and seen a pillow.

375
00:22:26,000 --> 00:22:34,480
Speaker 1: Then in the camp stove, sleep machine, open bag of marshmell.

376
00:22:34,600 --> 00:22:37,840
Speaker 1: Isn't a stick now? I took a couple of cat

377
00:22:37,960 --> 00:22:41,240
Speaker 1: naps here at work, and uh, such that I was like,

378
00:22:41,359 --> 00:22:44,600
Speaker 1: you know what, some countries and companies embrace this and

379
00:22:45,320 --> 00:22:48,440
Speaker 1: there's a lot of value to to knocking out for

380
00:22:48,640 --> 00:22:51,080
Speaker 1: twenty or thirty minutes during the work day. Is that

381
00:22:51,200 --> 00:22:54,520
Speaker 1: what that one hr email they sent out was all about? Maybe?

382
00:22:54,840 --> 00:22:57,000
Speaker 1: Did you try to convince them of that? Did you

383
00:22:57,080 --> 00:22:59,680
Speaker 1: go to them and say, you know, some countries really

384
00:23:00,080 --> 00:23:03,800
Speaker 1: race this. Why don't you guys be more more continental?

385
00:23:04,200 --> 00:23:08,639
Speaker 1: At least don't fire me? Right? Yeah? So yeah, so

386
00:23:08,840 --> 00:23:13,040
Speaker 1: this is this is akin to that, you know, falling asleep.

387
00:23:13,119 --> 00:23:16,080
Speaker 1: But the key here is that it's unplanned, and with

388
00:23:16,240 --> 00:23:18,959
Speaker 1: narcilepsy it is straight up irresistible, you know, like when

389
00:23:19,000 --> 00:23:21,119
Speaker 1: you sit up and you like open your eyes a

390
00:23:21,160 --> 00:23:22,560
Speaker 1: little bit, You're like, well, I can't fall asleep. I

391
00:23:22,600 --> 00:23:25,000
Speaker 1: gotta I gotta stay a week because I'm being paid

392
00:23:25,119 --> 00:23:27,760
Speaker 1: right now. Like if you have narcalypsy, you can't do that.

393
00:23:27,960 --> 00:23:31,040
Speaker 1: You just fall asleep and you're out. And the other

394
00:23:31,160 --> 00:23:34,880
Speaker 1: key is you feel really good and freshed right after

395
00:23:35,000 --> 00:23:38,320
Speaker 1: one of those sleep attacks, yeah, which is uh, it's

396
00:23:38,560 --> 00:23:41,560
Speaker 1: it's weird to think that ten seconds of that can

397
00:23:41,680 --> 00:23:44,920
Speaker 1: refresh you. I know, it is very weird, but that's

398
00:23:45,000 --> 00:23:48,160
Speaker 1: part of it for sure. So cataplexy, which we've talked

399
00:23:48,160 --> 00:23:52,320
Speaker 1: about the fainting goat like thing. Um you mentioned positive

400
00:23:52,320 --> 00:23:58,920
Speaker 1: emotions can trigger it, um, being surprised, laughter, elation, sometimes

401
00:23:59,000 --> 00:24:02,240
Speaker 1: anger which is not pause sative, but intense emotions like

402
00:24:02,320 --> 00:24:06,320
Speaker 1: that can triggered this. And it can be everything from

403
00:24:06,400 --> 00:24:08,240
Speaker 1: like you said, your head just sort of nodding down

404
00:24:08,720 --> 00:24:12,359
Speaker 1: to full on just collapsing, yeah, which is called a

405
00:24:12,440 --> 00:24:15,160
Speaker 1: drop attack, which are kind of dangerous. You can get

406
00:24:15,200 --> 00:24:18,800
Speaker 1: banged up pretty bad because this is not necessarily you

407
00:24:19,000 --> 00:24:21,000
Speaker 1: falling asleep or fainting or as a matter of fact,

408
00:24:21,040 --> 00:24:26,479
Speaker 1: it's not that. Yeah, you're up, your totally conscious, you are, Um,

409
00:24:27,040 --> 00:24:29,320
Speaker 1: you just can't control your muscles all of a sudden

410
00:24:29,400 --> 00:24:32,879
Speaker 1: for a very short period of time. Yeah. And interestingly,

411
00:24:33,240 --> 00:24:36,000
Speaker 1: and which is a good news, which is good news

412
00:24:36,119 --> 00:24:41,360
Speaker 1: is that as you get older, um, cataplexy amount actually improve. Yeah,

413
00:24:41,400 --> 00:24:44,040
Speaker 1: that is good news because taking a fall in the

414
00:24:44,119 --> 00:24:46,480
Speaker 1: hallway at you know, eighty years old is much different

415
00:24:46,520 --> 00:24:51,440
Speaker 1: than an eighteen for sure. Um, let's see. Oh, there's

416
00:24:51,440 --> 00:24:55,280
Speaker 1: also sleep paralysis, which we did an entire episode one. Um,

417
00:24:55,680 --> 00:24:59,879
Speaker 1: it's not fun. It frequently is accompanied by hallucinations, with

418
00:25:00,000 --> 00:25:02,680
Speaker 1: which is another symptom we'll talk about next. But sleep

419
00:25:02,680 --> 00:25:06,320
Speaker 1: paralysis was first described by a physician who had a

420
00:25:06,400 --> 00:25:10,440
Speaker 1: patient that presented with narcolepsy, and this guy figured out

421
00:25:10,440 --> 00:25:12,719
Speaker 1: there was such a thing as sleep paralysis. But it's basically,

422
00:25:13,040 --> 00:25:16,040
Speaker 1: when you're falling asleep or waking up, there's a there's

423
00:25:16,080 --> 00:25:19,760
Speaker 1: a like a few fleeting moments where you can't move

424
00:25:20,720 --> 00:25:24,160
Speaker 1: at all. You're paralyzed, and it's not pleasant one bit.

425
00:25:24,520 --> 00:25:27,840
Speaker 1: So if you are having a sleep attack and you're

426
00:25:27,880 --> 00:25:30,160
Speaker 1: coming in and out of sleep, you know, a bunch

427
00:25:30,200 --> 00:25:32,680
Speaker 1: of times a day, and you feel paralyzed as you're

428
00:25:32,720 --> 00:25:35,080
Speaker 1: coming in and out of sleep, um, and you don't

429
00:25:35,119 --> 00:25:38,320
Speaker 1: know what's going on, it can make the whole narcoleptic

430
00:25:38,520 --> 00:25:44,959
Speaker 1: norcalyptic experience a lot more terrifying. Yeah, as well. Hallucinations, Um,

431
00:25:45,480 --> 00:25:48,239
Speaker 1: these can come at the onset of sleep or at

432
00:25:48,280 --> 00:25:51,080
Speaker 1: the end of sleep. Um. They can be really scary.

433
00:25:51,680 --> 00:25:54,359
Speaker 1: Sometimes it could just be hearing a noise. What was

434
00:25:54,400 --> 00:25:56,040
Speaker 1: the one thing we talked about the time where we

435
00:25:56,680 --> 00:26:03,560
Speaker 1: you hear a loud noise, explode head that's exploding head. Somehow,

436
00:26:03,640 --> 00:26:08,359
Speaker 1: all this seems to be related somehow, right, Yeah, I

437
00:26:08,480 --> 00:26:09,959
Speaker 1: think so. Yeah, I think a lot of it has

438
00:26:10,040 --> 00:26:12,040
Speaker 1: to do with the neurons that we'll talk about in

439
00:26:12,040 --> 00:26:16,639
Speaker 1: a little bit. So, Um, the hallucinations, when they happen

440
00:26:16,680 --> 00:26:20,959
Speaker 1: when you're waking up, they're called hypno pompic, and when

441
00:26:21,000 --> 00:26:25,120
Speaker 1: you're falling asleep, those are the hypnagogic that we mentioned earlier. Yeah,

442
00:26:25,119 --> 00:26:28,240
Speaker 1: and again they very frequently accompany sleep paralysis, and that

443
00:26:28,440 --> 00:26:31,919
Speaker 1: like you can't move and you're hallucinating a demon standing

444
00:26:31,960 --> 00:26:34,879
Speaker 1: on your chest, right, that's why you can't move. And

445
00:26:35,000 --> 00:26:38,200
Speaker 1: again this is happening to you many many times a

446
00:26:38,320 --> 00:26:42,440
Speaker 1: day against your will, and it's it makes it unpleasant.

447
00:26:43,240 --> 00:26:47,280
Speaker 1: And then there's also something called disrupted nighttime sleep, which

448
00:26:47,400 --> 00:26:52,000
Speaker 1: is basically the exact polar opposite of excessive daytime sleepiness,

449
00:26:52,400 --> 00:26:54,520
Speaker 1: where during the night, when everybody else is asleep and

450
00:26:54,600 --> 00:26:57,600
Speaker 1: when you wish you were sleeping, you might be wide awake.

451
00:26:58,040 --> 00:27:01,840
Speaker 1: So that again your sleep pattern is not concentrated into

452
00:27:01,920 --> 00:27:04,560
Speaker 1: eight hours at night, it's spread out in about eight

453
00:27:04,640 --> 00:27:09,040
Speaker 1: hours throughout a twenty four hour period. That's right. So

454
00:27:09,640 --> 00:27:12,639
Speaker 1: we talked a lot about, um, the various sort of

455
00:27:12,720 --> 00:27:16,360
Speaker 1: explanations for this over the years, UM, what they thought

456
00:27:16,480 --> 00:27:19,040
Speaker 1: was going on, and that it wasn't until the nineteen

457
00:27:19,119 --> 00:27:21,320
Speaker 1: nineties that they kind of zeroed in on what they

458
00:27:21,359 --> 00:27:23,480
Speaker 1: think is going on now, which to me and you

459
00:27:23,720 --> 00:27:27,880
Speaker 1: holds a lot of promise. Um. But was the year

460
00:27:28,040 --> 00:27:32,639
Speaker 1: that they finally discovered and isolated the chemical in the

461
00:27:32,720 --> 00:27:34,639
Speaker 1: brain that seems to be the cause of all this,

462
00:27:34,840 --> 00:27:41,320
Speaker 1: and it's called hypocretan. Hippocretan. I want to say, hypocretan,

463
00:27:41,720 --> 00:27:46,080
Speaker 1: How do too? So let's do, okay, hypocretan. Yeah, So

464
00:27:46,200 --> 00:27:50,120
Speaker 1: they isolated that and there we have our um cousins,

465
00:27:50,200 --> 00:27:52,159
Speaker 1: the rats to thank for this, because they did a

466
00:27:52,240 --> 00:27:55,560
Speaker 1: lot of rats tests and figured out from those tests

467
00:27:55,840 --> 00:27:59,240
Speaker 1: just how um how this whole thing works. But what

468
00:27:59,359 --> 00:28:05,360
Speaker 1: they figured out out is that hypocretan has some has

469
00:28:05,400 --> 00:28:08,199
Speaker 1: a few different functions, but its main function is maintaining

470
00:28:08,680 --> 00:28:13,160
Speaker 1: wakefulness in US humans. And it is a it's a peptide.

471
00:28:13,200 --> 00:28:16,600
Speaker 1: It also has another name, Chuck called orexin, and it's

472
00:28:16,640 --> 00:28:20,520
Speaker 1: the exact same neurochemical. But it would just happen to

473
00:28:20,600 --> 00:28:23,159
Speaker 1: be discovered independently by two different groups at about the

474
00:28:23,200 --> 00:28:26,240
Speaker 1: same time, so it has two names. Still they haven't

475
00:28:26,240 --> 00:28:30,240
Speaker 1: settled on one. But it basically goes around and says, hey, saratonin,

476
00:28:30,320 --> 00:28:33,640
Speaker 1: you're looking good. Here's a little boost. Hey, Nora epinephrin,

477
00:28:34,000 --> 00:28:36,680
Speaker 1: you're looking great yourself. Here's another little boost. And so

478
00:28:36,880 --> 00:28:39,840
Speaker 1: all of these neurochemicals that keep us awake and alert

479
00:28:40,280 --> 00:28:44,880
Speaker 1: get a boost from hypocretan so that they can do

480
00:28:45,040 --> 00:28:48,240
Speaker 1: their job better. And what they found is that people

481
00:28:48,400 --> 00:28:56,040
Speaker 1: with type one narcolepsy UM have about nine fewer of

482
00:28:56,240 --> 00:28:59,640
Speaker 1: this very specialized cluster of neurons in the brain that

483
00:28:59,760 --> 00:29:04,440
Speaker 1: are responsible for producing all of the hypocretan in our bodies. Yeah,

484
00:29:04,480 --> 00:29:08,680
Speaker 1: that's case closed, right basically. Yeah, I think the only

485
00:29:08,760 --> 00:29:12,720
Speaker 1: thing left to explain is two fold. One, exactly why

486
00:29:13,440 --> 00:29:17,440
Speaker 1: the hypocretan is is um the hype the neurons that

487
00:29:17,520 --> 00:29:21,080
Speaker 1: produce hypocreting are so diminished. And it seems like they've

488
00:29:21,080 --> 00:29:23,360
Speaker 1: basically explained that one and then to what to do

489
00:29:23,480 --> 00:29:25,920
Speaker 1: about it. That's the big one. Yeah, and we should

490
00:29:25,960 --> 00:29:29,440
Speaker 1: mention too that UM, there are about eighty six million,

491
00:29:29,680 --> 00:29:33,240
Speaker 1: I'm sorry billion neurons in the brain and only about

492
00:29:33,480 --> 00:29:36,400
Speaker 1: between a hundred and two hundred thousand neurons produce hypocretan.

493
00:29:36,560 --> 00:29:41,560
Speaker 1: So it is a very specialized cluster of neural cells. Yeah,

494
00:29:41,720 --> 00:29:44,040
Speaker 1: but it also makes it really vulnerable too, and they're

495
00:29:44,040 --> 00:29:46,840
Speaker 1: all in one space in the rear of the hypothalamus.

496
00:29:47,440 --> 00:29:51,400
Speaker 1: So it's really weird that evolution was like, that's fine,

497
00:29:51,520 --> 00:29:54,400
Speaker 1: this is a really really really important chemical, um, but

498
00:29:54,560 --> 00:29:57,520
Speaker 1: we're just gonna localize it right here in this one

499
00:29:57,600 --> 00:30:00,760
Speaker 1: spot to just a hundred thousand neurons. Yeah. And it's

500
00:30:00,800 --> 00:30:04,720
Speaker 1: also really weird that if you only have type two narcolepsy,

501
00:30:05,400 --> 00:30:10,200
Speaker 1: you don't show any decrease in hypocretan right right when

502
00:30:10,320 --> 00:30:12,640
Speaker 1: that's just the one where you have sleep attacks and

503
00:30:12,760 --> 00:30:16,440
Speaker 1: not cataplexy. And it is really weird. And that's why

504
00:30:16,480 --> 00:30:18,000
Speaker 1: I was saying, like, I wonder if that's going to

505
00:30:18,080 --> 00:30:20,400
Speaker 1: be broken out eventually in the future into its own

506
00:30:20,840 --> 00:30:24,880
Speaker 1: disorder or disease. But the current thinking for that is

507
00:30:25,040 --> 00:30:29,720
Speaker 1: is that that is a less pronounced or less advanced

508
00:30:30,000 --> 00:30:35,320
Speaker 1: case of type one narcolepsy to where you're probably going

509
00:30:35,400 --> 00:30:39,360
Speaker 1: to eventually get cataplexy, or you may never get cataplexy,

510
00:30:39,640 --> 00:30:43,959
Speaker 1: but your your case of narcolepsy just stopped progressing at

511
00:30:44,000 --> 00:30:47,920
Speaker 1: something point. That's what they think currently. UM. A lot

512
00:30:48,000 --> 00:30:52,280
Speaker 1: of the sleepiness of narcolepsy. This, you know, it's a

513
00:30:52,360 --> 00:30:55,240
Speaker 1: theory at least from researchers, is that it's a consequence

514
00:30:55,320 --> 00:30:59,240
Speaker 1: of sleep state instability. Uh. And that's something I know

515
00:30:59,480 --> 00:31:03,440
Speaker 1: we talked about before, that that threshold between being awake

516
00:31:03,760 --> 00:31:06,880
Speaker 1: and being asleep and those lines getting blurred and crossing over.

517
00:31:07,920 --> 00:31:10,120
Speaker 1: And I guess that must have been sleep paralysis that

518
00:31:10,160 --> 00:31:13,080
Speaker 1: we talked about that. I think so because that's, um,

519
00:31:13,440 --> 00:31:16,920
Speaker 1: that is like an example of like wait, that is

520
00:31:17,000 --> 00:31:21,240
Speaker 1: like wakefulness intruding on R E M sleep. It's almost

521
00:31:21,280 --> 00:31:26,680
Speaker 1: like the opposite of narcolepsy, people experiencing sleep paralysis without narcolepsy.

522
00:31:27,040 --> 00:31:30,040
Speaker 1: It's kind of like that, but it it's it's ultimately

523
00:31:30,120 --> 00:31:33,959
Speaker 1: that it's a consequence of your brain no longer able

524
00:31:34,080 --> 00:31:39,400
Speaker 1: to being able to hold the switch down between the

525
00:31:39,520 --> 00:31:43,640
Speaker 1: on off switch between sleep and wakefulness. Right. So it's

526
00:31:43,720 --> 00:31:48,640
Speaker 1: like hypocritin is the thumb that holds the on off

527
00:31:48,720 --> 00:31:53,240
Speaker 1: switch in place. Without it, that switches kind of hair trigger,

528
00:31:53,720 --> 00:31:56,640
Speaker 1: so that um, it's just kind of can shift back

529
00:31:56,680 --> 00:32:01,040
Speaker 1: and forth between on and off really easily and really quickly. Um.

530
00:32:01,320 --> 00:32:04,959
Speaker 1: And so without that hypocrite and that's that you can

531
00:32:05,080 --> 00:32:07,640
Speaker 1: just kind of go in between wakefulness and R E

532
00:32:07,840 --> 00:32:10,640
Speaker 1: M sleep with no transition and just at the drop

533
00:32:10,760 --> 00:32:13,120
Speaker 1: of a hat basically, so they think that that's it,

534
00:32:13,280 --> 00:32:16,560
Speaker 1: that it is a a lack of hypocriting that is

535
00:32:17,080 --> 00:32:22,320
Speaker 1: responsible at least for type one narcilepsy, which is narcilepsy

536
00:32:22,360 --> 00:32:27,880
Speaker 1: with cataplexy. Should we take the break now? Sure? All right,

537
00:32:27,960 --> 00:32:30,440
Speaker 1: let's take a break because we're going to get into

538
00:32:30,800 --> 00:32:33,840
Speaker 1: our third act here with a very what I think

539
00:32:33,920 --> 00:32:36,160
Speaker 1: is the most interesting part of all this, which is

540
00:32:36,280 --> 00:32:38,840
Speaker 1: what it has to do with your genes and your

541
00:32:38,880 --> 00:33:12,600
Speaker 1: immune system right after this. All right, so I promised

542
00:33:12,640 --> 00:33:16,920
Speaker 1: talk of genes in your immune system. This is super

543
00:33:17,000 --> 00:33:19,600
Speaker 1: interesting to me because I feel like they're really zero

544
00:33:19,880 --> 00:33:24,200
Speaker 1: zeroing in on what's going on here with this research. Dude,

545
00:33:24,520 --> 00:33:27,160
Speaker 1: how many episodes have we done on stuff like this

546
00:33:27,360 --> 00:33:30,640
Speaker 1: where we're like, they think maybe this or studies are

547
00:33:30,680 --> 00:33:35,480
Speaker 1: started coming. We have caught this at like peak ripeness

548
00:33:36,000 --> 00:33:38,680
Speaker 1: right before everybody knows that it's just so plain and

549
00:33:38,760 --> 00:33:41,480
Speaker 1: obvious and it's been talked about so much, but right

550
00:33:41,600 --> 00:33:46,000
Speaker 1: after all of these important advanced advancements in the study

551
00:33:46,040 --> 00:33:48,600
Speaker 1: of it have really kind of come together and gelled.

552
00:33:48,640 --> 00:33:52,320
Speaker 1: I mean, it is perfectly fresh. Yeah, it is uh

553
00:33:53,440 --> 00:33:58,880
Speaker 1: a very rare satisfying feeling. I feel satisfied myself, so there.

554
00:33:59,160 --> 00:34:03,040
Speaker 1: They think there's a genetic basis for narcilepsy, but the

555
00:34:03,200 --> 00:34:06,520
Speaker 1: genes that are involved in our ecclepsy really aren't involved

556
00:34:06,600 --> 00:34:10,120
Speaker 1: with sleep. It's about your immune system. Um, so how

557
00:34:10,200 --> 00:34:16,560
Speaker 1: it goes is a little something like this there, alright, man,

558
00:34:18,080 --> 00:34:20,360
Speaker 1: there are genes that code for these T cell receptors

559
00:34:20,640 --> 00:34:24,800
Speaker 1: and the h l A gen human lucacite antigen, and

560
00:34:25,040 --> 00:34:28,400
Speaker 1: not everyone has this variant, but if you do, you're

561
00:34:28,440 --> 00:34:33,080
Speaker 1: gonna have about a greater chance of having anarcilepsy. Yeah,

562
00:34:33,280 --> 00:34:36,239
Speaker 1: that variant of the h l A gene very important.

563
00:34:36,560 --> 00:34:40,800
Speaker 1: That's a big increase, Yeah, is for real because a

564
00:34:40,880 --> 00:34:43,200
Speaker 1: lot of those will show like the relative increase, it

565
00:34:43,320 --> 00:34:46,799
Speaker 1: increases your risk, you know, but if you look at

566
00:34:46,840 --> 00:34:49,840
Speaker 1: the absolute increase, it's like well that you know, you

567
00:34:49,960 --> 00:34:53,719
Speaker 1: have you know, one point five times the chance or

568
00:34:53,760 --> 00:34:58,280
Speaker 1: something like that times likely or is definitely a huge increase.

569
00:34:58,360 --> 00:35:01,359
Speaker 1: For sure. My hat is all to that one. Yeah.

570
00:35:01,480 --> 00:35:04,200
Speaker 1: But so what they're thinking is that it's actually the

571
00:35:04,320 --> 00:35:07,640
Speaker 1: basis of narcolepsy is an autoimmune disease, and that is

572
00:35:07,719 --> 00:35:10,520
Speaker 1: what's killing off your immune system, is killing off those

573
00:35:10,600 --> 00:35:17,080
Speaker 1: hypocreting producing neurons. Yes, yes, just like crones irritable bowel

574
00:35:17,160 --> 00:35:23,440
Speaker 1: syndrome or rheumatoid arthritis. It's your body turning on itself.

575
00:35:23,600 --> 00:35:26,920
Speaker 1: It's mistaken, so it attacks itself. Your immune system attacks

576
00:35:26,960 --> 00:35:29,279
Speaker 1: your own body. And in this case, in the case

577
00:35:29,360 --> 00:35:34,440
Speaker 1: of an ecalepsy, they think that something about those hypocriting

578
00:35:35,000 --> 00:35:39,440
Speaker 1: um hypocreting producing neurons I guess are producing something that

579
00:35:39,840 --> 00:35:43,520
Speaker 1: seems like an antigen to your body. If you have

580
00:35:43,800 --> 00:35:47,880
Speaker 1: that specific variant of that hl A Jean and attacks them,

581
00:35:48,120 --> 00:35:51,480
Speaker 1: kills off those neurons. You don't have any hypocreting any longer,

582
00:35:51,719 --> 00:35:55,360
Speaker 1: and so you can't maintain wakefulness, and so sleep and

583
00:35:55,440 --> 00:35:59,200
Speaker 1: wakefulness just toggle back and forth throughout your day. Are

584
00:35:59,239 --> 00:36:01,719
Speaker 1: you gonna drop this stropped a caucus bomb? I think

585
00:36:01,800 --> 00:36:06,839
Speaker 1: you should. I think I understand it. But just after

586
00:36:07,000 --> 00:36:10,520
Speaker 1: the onset of narcolepsy, it looks like you have an

587
00:36:10,560 --> 00:36:15,240
Speaker 1: increased level of antibodies against streptocaucus and that's like strep throat,

588
00:36:15,480 --> 00:36:18,919
Speaker 1: and there are other infections involved, and so they've also

589
00:36:19,040 --> 00:36:21,680
Speaker 1: tied that to the time of year. Uh A. Narcolepsy

590
00:36:21,800 --> 00:36:24,919
Speaker 1: usually begins in late spring and early summer, which would

591
00:36:25,000 --> 00:36:27,640
Speaker 1: kind of make sense that there's an autoimmunitat going on

592
00:36:27,760 --> 00:36:31,239
Speaker 1: against those neurons triggered by strep throat or some other

593
00:36:31,360 --> 00:36:34,840
Speaker 1: kind of infection you get during the winter. Yeah, like

594
00:36:34,960 --> 00:36:37,520
Speaker 1: your immune system just goes bonkers because it's strap and

595
00:36:37,560 --> 00:36:39,200
Speaker 1: it's like what else, what else can I go after?

596
00:36:39,280 --> 00:36:41,680
Speaker 1: I'm really primed and pumped, And for some reason it

597
00:36:41,760 --> 00:36:46,320
Speaker 1: goes after your hypocretan producing neurons in your hypothalamus. That's nuts.

598
00:36:46,760 --> 00:36:49,520
Speaker 1: So your immune response is triggered by an actual infection,

599
00:36:49,600 --> 00:36:52,080
Speaker 1: they think, and the reason why they think this, and

600
00:36:52,160 --> 00:36:56,120
Speaker 1: it greatly pains me to to to reveal this, I know.

601
00:36:57,120 --> 00:37:01,680
Speaker 1: But there is a vaccine called endem Ricks that is

602
00:37:01,760 --> 00:37:04,279
Speaker 1: no longer available anywhere in the world. But it was

603
00:37:04,400 --> 00:37:07,120
Speaker 1: hot and heavy as a vaccine against H one N

604
00:37:07,239 --> 00:37:11,120
Speaker 1: one swine flu, and it was a really potent vaccine

605
00:37:11,120 --> 00:37:14,640
Speaker 1: against H one N one swine flu, and some European

606
00:37:14,719 --> 00:37:18,880
Speaker 1: Northern European countries during the two thousand nine to two

607
00:37:18,920 --> 00:37:22,759
Speaker 1: thousand eleven swine flu pandemic chose to use this to

608
00:37:22,840 --> 00:37:28,040
Speaker 1: inoculate their population with right. Well, there were reports that

609
00:37:28,200 --> 00:37:32,760
Speaker 1: have been backed up by studies, not just in um Finland,

610
00:37:32,840 --> 00:37:34,640
Speaker 1: which was a big place where this happened. But in

611
00:37:34,719 --> 00:37:37,520
Speaker 1: other places like the UK did studies to that found

612
00:37:37,560 --> 00:37:42,720
Speaker 1: the same results that there was a link between pandemics

613
00:37:43,239 --> 00:37:48,759
Speaker 1: and narcolepsy, that the pandemics triggered that immune response that

614
00:37:48,920 --> 00:37:52,920
Speaker 1: ultimately led to the immune system attacking the hypo cretan

615
00:37:53,280 --> 00:37:57,880
Speaker 1: producing neurons, so that H one N one vaccine brought

616
00:37:57,960 --> 00:38:02,840
Speaker 1: on a life long chronic case of narcolepsy. Yeah, I

617
00:38:02,960 --> 00:38:05,160
Speaker 1: thought that was hard to say, what not? Yeah, it

618
00:38:05,320 --> 00:38:08,040
Speaker 1: really was. I really really hate saying stuff like that,

619
00:38:08,760 --> 00:38:11,399
Speaker 1: I know, but you know what, you gotta we gotta

620
00:38:11,719 --> 00:38:16,320
Speaker 1: preach the science, and the science appears valid. Here dozens

621
00:38:16,400 --> 00:38:20,759
Speaker 1: of kids and um Finland developed narcolepsy, and I think

622
00:38:20,840 --> 00:38:24,640
Speaker 1: the new rate of cases of narcilepsy and kids increased

623
00:38:24,960 --> 00:38:30,120
Speaker 1: eight to twelvefold. And you know, I think out of

624
00:38:30,160 --> 00:38:33,080
Speaker 1: the fifty four kids who are diagnosed with narcolepsy, fifty

625
00:38:33,120 --> 00:38:36,799
Speaker 1: of them had had the vaccine. So yeah, and I mean,

626
00:38:36,880 --> 00:38:39,920
Speaker 1: these like these numbers are really really small, but if

627
00:38:39,960 --> 00:38:43,080
Speaker 1: you think about it, so four kids apparently in two

628
00:38:43,120 --> 00:38:48,239
Speaker 1: thousand and ten would have been diagnosed with narcolepsy had

629
00:38:48,280 --> 00:38:51,760
Speaker 1: that pandemic not happened in that or that particular vaccine

630
00:38:51,800 --> 00:38:55,200
Speaker 1: not been administered, but because it was, the number was

631
00:38:55,400 --> 00:38:59,240
Speaker 1: fifty four, not four. So even though the numbers again

632
00:38:59,280 --> 00:39:04,600
Speaker 1: absolutely are rather small percentage wise, there, that's an enormous,

633
00:39:04,760 --> 00:39:10,799
Speaker 1: a mind boggling increase in the number of NARCOLEPSI diagnoses. Yeah,

634
00:39:10,880 --> 00:39:14,000
Speaker 1: and it was linked directly to that vaccine and they

635
00:39:14,480 --> 00:39:17,400
Speaker 1: I keep saying that, and they caught it and it

636
00:39:17,560 --> 00:39:21,200
Speaker 1: is no longer being given anywhere. It was never available

637
00:39:21,560 --> 00:39:25,400
Speaker 1: in the United States. So, uh, Finland just sort of

638
00:39:25,480 --> 00:39:27,840
Speaker 1: got the brunt of it. It seems like, yeah, Finland,

639
00:39:27,880 --> 00:39:31,279
Speaker 1: the UK had a bunch um. Their rate was one

640
00:39:32,080 --> 00:39:35,840
Speaker 1: case of diagnosed and narcolepsy for every fifty five thousand

641
00:39:36,560 --> 00:39:41,600
Speaker 1: UM inoculations and children I think six months to eighteen UM,

642
00:39:41,880 --> 00:39:46,120
Speaker 1: but that washed out to like sixteen sixteen people UM,

643
00:39:46,280 --> 00:39:47,959
Speaker 1: which still I mean, if you're one of those people,

644
00:39:48,040 --> 00:39:51,480
Speaker 1: you're like, well, son of a gun, that really sucks.

645
00:39:52,040 --> 00:39:54,480
Speaker 1: But here's the key, and this is really really important,

646
00:39:54,520 --> 00:39:57,279
Speaker 1: and this is how we will be able to still

647
00:39:57,480 --> 00:40:00,800
Speaker 1: use a vaccine that is viable and po and works

648
00:40:00,800 --> 00:40:05,080
Speaker 1: against swine flu without giving somebody anarcilepsy. And that is

649
00:40:05,640 --> 00:40:12,120
Speaker 1: personalized UM drugs based on gene tests UM DNA tests,

650
00:40:12,440 --> 00:40:16,960
Speaker 1: Because of those fifty kids in Finland that received the

651
00:40:17,040 --> 00:40:21,120
Speaker 1: vaccine in two thousand ten that developed narcolepsy, every single

652
00:40:21,200 --> 00:40:24,120
Speaker 1: one of them carried that specific variant of the h

653
00:40:24,280 --> 00:40:27,520
Speaker 1: l a gene that is tied to narcolepsy. So if

654
00:40:27,560 --> 00:40:30,359
Speaker 1: you just did a simple DNA test, which hopefully will

655
00:40:30,360 --> 00:40:33,279
Speaker 1: be widespread in just a few years, you'd say, oh, no,

656
00:40:33,480 --> 00:40:35,960
Speaker 1: I'm glad we did this. You can't have pandemics, you

657
00:40:36,040 --> 00:40:39,080
Speaker 1: might get an arcilepsy, or basically there's a percent chance

658
00:40:39,160 --> 00:40:41,680
Speaker 1: you're gonna get an ecolepsy. Um, we'll give you this

659
00:40:41,760 --> 00:40:44,400
Speaker 1: other vaccine instead that that has been shown not to

660
00:40:44,440 --> 00:40:47,239
Speaker 1: produce narcilepsy and people like you. That's right, and you

661
00:40:47,280 --> 00:40:51,480
Speaker 1: can refer to our episode on personalized medicine. Yes, right,

662
00:40:51,560 --> 00:40:53,879
Speaker 1: we should do a follow up on that one. Yeah,

663
00:40:53,960 --> 00:40:56,640
Speaker 1: I agree, So that on the list for six years

664
00:40:56,680 --> 00:41:00,520
Speaker 1: from now. So basically, you've got these gene that pre

665
00:41:00,800 --> 00:41:05,400
Speaker 1: predispose you to um your immune system mistakenly attacking that

666
00:41:05,520 --> 00:41:08,120
Speaker 1: part of your hypothalamus. There has to be some sort

667
00:41:08,120 --> 00:41:14,000
Speaker 1: of trigger, either an infection or pandemics, um something like that. Typically,

668
00:41:14,040 --> 00:41:16,200
Speaker 1: an infection was stripped and then there seemed to be

669
00:41:16,360 --> 00:41:20,840
Speaker 1: two age windows where you're particularly vulnerable around fifteen and

670
00:41:20,920 --> 00:41:23,759
Speaker 1: around thirty six. They have no idea about any of that.

671
00:41:24,160 --> 00:41:28,359
Speaker 1: They just have they're starting to put this data together. Yeah,

672
00:41:28,480 --> 00:41:31,040
Speaker 1: I bet you they'll figure that out too, agreed. I

673
00:41:31,160 --> 00:41:34,560
Speaker 1: really feel like narcolepsy is going to be like totally

674
00:41:34,640 --> 00:41:37,200
Speaker 1: incompletely figured out in the next decade. I couldnot be

675
00:41:37,360 --> 00:41:42,320
Speaker 1: more jazzed about it, really. Yeah. Love science just figuring

676
00:41:42,400 --> 00:41:46,600
Speaker 1: things out, you know, just just doggedly, you know, working

677
00:41:46,719 --> 00:41:49,840
Speaker 1: in building on you know, somebody else's work. It's just

678
00:41:50,440 --> 00:41:53,600
Speaker 1: it's a beautiful thing when it's done right. Agreed. So,

679
00:41:54,040 --> 00:41:57,319
Speaker 1: if you are going to be diagnosed with narcolepsi, there

680
00:41:57,360 --> 00:41:58,920
Speaker 1: are a couple of tests that they're going to give you.

681
00:41:59,280 --> 00:42:02,880
Speaker 1: What is called an overnight uh Polly som no Graham,

682
00:42:04,120 --> 00:42:07,040
Speaker 1: that's right, a p s g uh. And that is

683
00:42:07,160 --> 00:42:10,560
Speaker 1: a test when you uh, it's one of those tests.

684
00:42:10,600 --> 00:42:12,080
Speaker 1: It's like a sleep studies when you go in and

685
00:42:12,640 --> 00:42:17,480
Speaker 1: sleep for them basically, and yeah, and they measure a

686
00:42:17,560 --> 00:42:20,200
Speaker 1: lot of things. They measure your brain waves, uh, they

687
00:42:20,239 --> 00:42:24,000
Speaker 1: measure your heart rate, eye movements, limb movements, muscle tone, respiration.

688
00:42:24,960 --> 00:42:26,680
Speaker 1: Get a lot of info there and then they'll say,

689
00:42:26,760 --> 00:42:28,719
Speaker 1: now you're gonna this is gonna be followed by the

690
00:42:28,800 --> 00:42:32,919
Speaker 1: multiple sleep latency test, which also sounds kind of fun

691
00:42:33,320 --> 00:42:36,080
Speaker 1: because that measures how quickly you fall asleep for a

692
00:42:36,200 --> 00:42:38,960
Speaker 1: nap every couple of hours during the day. I know,

693
00:42:39,120 --> 00:42:40,480
Speaker 1: when you have to go in for when you're like,

694
00:42:40,520 --> 00:42:43,200
Speaker 1: I gotta go to a doctor's appointment. Somebody goes, oh, sorry,

695
00:42:43,239 --> 00:42:45,080
Speaker 1: you go no, No, it's great, It's gonna be the

696
00:42:45,160 --> 00:42:48,719
Speaker 1: greatest day of my life. Yeah, those rooms make me sleepy. Um.

697
00:42:49,280 --> 00:42:51,160
Speaker 1: I could see some people being like, I can't go

698
00:42:51,320 --> 00:42:54,360
Speaker 1: sleep in a room, but I was well known as

699
00:42:54,400 --> 00:42:56,600
Speaker 1: a child for falling asleep in like a dentist chair

700
00:42:57,160 --> 00:43:00,560
Speaker 1: waiting for waiting for the dentist to come in. Um

701
00:43:00,960 --> 00:43:02,920
Speaker 1: or in a in a waiting room for are not

702
00:43:03,000 --> 00:43:05,200
Speaker 1: a waiting room, but in the exam room for a doctor.

703
00:43:05,560 --> 00:43:09,720
Speaker 1: I still get sleepy. And those just super clean, super cool,

704
00:43:09,960 --> 00:43:14,600
Speaker 1: quiet rooms with fluorescent lighting. It just zaps me. Yeah,

705
00:43:15,000 --> 00:43:20,400
Speaker 1: that's very odd, very odd. So, uh, four or five

706
00:43:20,480 --> 00:43:23,000
Speaker 1: knap opportunities during the day, they're gonna see how fast

707
00:43:23,080 --> 00:43:26,080
Speaker 1: you fall asleep, and if you followup, if you have narcalepsy,

708
00:43:26,120 --> 00:43:29,319
Speaker 1: you're gonna fall asleep super easy UM compared to someone

709
00:43:29,360 --> 00:43:33,200
Speaker 1: without an earcalepsy. Right, so that's that's a pretty big giveaway. UM.

710
00:43:33,320 --> 00:43:35,640
Speaker 1: If they're still like, I don't know, this is all this,

711
00:43:35,840 --> 00:43:38,880
Speaker 1: You know, this person patient history that we've taken in

712
00:43:38,960 --> 00:43:42,640
Speaker 1: these tests are inconclusive, they might test your cerebro spinal

713
00:43:42,680 --> 00:43:49,080
Speaker 1: fluid because UM hypocretan levels are very easily tested through that. No,

714
00:43:49,440 --> 00:43:51,840
Speaker 1: not nearly as fun, because they're gonna go through the

715
00:43:51,920 --> 00:43:54,200
Speaker 1: base of your skull, that hole in your skull where

716
00:43:54,200 --> 00:43:58,239
Speaker 1: your spinal cord. Yeah, I know. I hope that that

717
00:43:58,360 --> 00:44:00,560
Speaker 1: never befalls either one of us into anyone who's ever

718
00:44:00,640 --> 00:44:03,440
Speaker 1: had to go through that. We are very very sorry. UM.

719
00:44:04,320 --> 00:44:07,319
Speaker 1: But that also is looking like a place where they're

720
00:44:07,360 --> 00:44:10,200
Speaker 1: trying to figure out how to cure UH an ecolepsy,

721
00:44:10,360 --> 00:44:13,719
Speaker 1: because as it stands right now, if you're diagnosed with narcilepsy,

722
00:44:14,040 --> 00:44:19,560
Speaker 1: you've just been given a lifelong chronic diagnosis. You know,

723
00:44:19,840 --> 00:44:22,080
Speaker 1: there there's no cure for an eclepsy as it stands

724
00:44:22,200 --> 00:44:25,799
Speaker 1: right now, but there are treatments and from everything I read,

725
00:44:26,360 --> 00:44:30,560
Speaker 1: if you are actively treating your narcolepsy UM through a

726
00:44:30,760 --> 00:44:35,360
Speaker 1: doctor usually with prescriptions and also like behavioral modification, not

727
00:44:35,520 --> 00:44:37,840
Speaker 1: like you know, hooking you up to a car battery

728
00:44:37,920 --> 00:44:41,640
Speaker 1: and changing your behavior like that, more like making sure

729
00:44:41,680 --> 00:44:44,759
Speaker 1: you stick to like a good sleep pattern. Um, you

730
00:44:45,000 --> 00:44:48,040
Speaker 1: can very much keep your symptoms in check for sure.

731
00:44:48,239 --> 00:44:50,360
Speaker 1: It doesn't have to ruin your life. The trouble is

732
00:44:50,480 --> 00:44:55,040
Speaker 1: is that it's very frequently misdiagnosed and it's underdiagnosed, and

733
00:44:55,160 --> 00:44:59,319
Speaker 1: they think it's because it's occurs UM with so many

734
00:44:59,440 --> 00:45:04,439
Speaker 1: co morbidities like depression, where the doctors like, well, sure

735
00:45:04,440 --> 00:45:07,000
Speaker 1: you're falling asleep all day because you're just sitting around

736
00:45:07,080 --> 00:45:09,000
Speaker 1: on the couch, because you don't have any low energy

737
00:45:09,040 --> 00:45:13,239
Speaker 1: because you're depressed. Really, it's possible that you you have

738
00:45:13,600 --> 00:45:17,880
Speaker 1: developed depression because of the narcilepsy. UM. They haven't figured

739
00:45:17,880 --> 00:45:20,560
Speaker 1: out if they're co morbid or if the if one

740
00:45:20,680 --> 00:45:22,640
Speaker 1: causes the other, but they're pretty sure that an arc

741
00:45:22,640 --> 00:45:26,680
Speaker 1: eilepsy causes the depression. Yeah, you're probably going to get

742
00:45:26,719 --> 00:45:30,800
Speaker 1: a prescription for something um it maybe or it's probably

743
00:45:30,880 --> 00:45:33,960
Speaker 1: likely to be a daphanel these days. When we talked

744
00:45:34,000 --> 00:45:37,080
Speaker 1: about that in Our is Science Phasing out sleep episode, Yeah,

745
00:45:37,239 --> 00:45:39,080
Speaker 1: we've done a bunch of sleep once. I forgot about

746
00:45:39,120 --> 00:45:42,840
Speaker 1: that one riddling you might get uh, you know, it

747
00:45:42,920 --> 00:45:45,200
Speaker 1: says you know, in the old days meth amphetamins. But

748
00:45:46,360 --> 00:45:50,920
Speaker 1: they still prescribe a variation of speed for I'm not

749
00:45:50,960 --> 00:45:54,480
Speaker 1: sure if it's an ecailepsy, but I know an individual

750
00:45:54,640 --> 00:46:00,239
Speaker 1: that I was diagnosed with. I guess just it's dream

751
00:46:00,280 --> 00:46:05,160
Speaker 1: daytime sleepiness. Not they're in chores fast enough, No, no

752
00:46:05,360 --> 00:46:07,960
Speaker 1: for falling or get just feeling really really sleepy during

753
00:46:08,000 --> 00:46:09,880
Speaker 1: the day. And did the sleep study and all that,

754
00:46:10,040 --> 00:46:13,120
Speaker 1: and they were prescribed kind of whatever the version of

755
00:46:13,200 --> 00:46:16,359
Speaker 1: speed as these days was. When was that? When were

756
00:46:16,400 --> 00:46:19,520
Speaker 1: they prescribed? That was at nineties last year? Oh? Really,

757
00:46:19,600 --> 00:46:23,080
Speaker 1: I'm surprised because from what I saw, Madafanil is like, no,

758
00:46:23,320 --> 00:46:25,879
Speaker 1: don't need anything else, just take me daffanel. You don't

759
00:46:25,880 --> 00:46:29,480
Speaker 1: get addicted to it. There are very few side effects. Um,

760
00:46:29,760 --> 00:46:32,080
Speaker 1: it's supposed to just be like a wonder drug basically.

761
00:46:33,200 --> 00:46:39,200
Speaker 1: Mm hmmm. I don't. Anytime I hear that, I get dubious, right,

762
00:46:39,520 --> 00:46:42,680
Speaker 1: I think that's pretty pretty smart. Actually, Um, they might

763
00:46:42,760 --> 00:46:47,120
Speaker 1: also prescribe you anidepressant like an ss r i um,

764
00:46:47,320 --> 00:46:50,040
Speaker 1: which inhibits reuptake a serotonin, which means you have more

765
00:46:50,120 --> 00:46:53,320
Speaker 1: serotonin in your brain, which would make sense because what

766
00:46:53,600 --> 00:46:58,240
Speaker 1: hypocretan does is boost your levels of serotonin and other neurochemicals.

767
00:46:58,560 --> 00:47:00,960
Speaker 1: So this is kind of going around down that problem

768
00:47:01,080 --> 00:47:05,000
Speaker 1: and just making you have more serotonin than before, which

769
00:47:05,040 --> 00:47:11,240
Speaker 1: apparently helps maintain r E M sleep the barrier between

770
00:47:11,320 --> 00:47:14,360
Speaker 1: that and wakefulness a lot better. Yeah. And then the

771
00:47:14,600 --> 00:47:17,400
Speaker 1: final thing, which is really interesting and promising, is they

772
00:47:17,480 --> 00:47:19,959
Speaker 1: did the sort of logical thing, which is, hey, maybe

773
00:47:20,000 --> 00:47:22,279
Speaker 1: we can just get some more hypocreting in your body,

774
00:47:23,600 --> 00:47:25,800
Speaker 1: because if that's the problem, why don't we just do that?

775
00:47:26,719 --> 00:47:28,920
Speaker 1: So they cut out fat hauled legs of it for

776
00:47:29,080 --> 00:47:32,640
Speaker 1: you at the doctor's office. Uh. There are different methods.

777
00:47:32,920 --> 00:47:38,840
Speaker 1: Cell transplantation, which is just implanting cells. Uh, maybe implantation

778
00:47:38,960 --> 00:47:43,360
Speaker 1: of the gene like gene therapy. Maybe just giving it

779
00:47:43,640 --> 00:47:46,759
Speaker 1: through your nose or injecting it into your body, That's

780
00:47:46,800 --> 00:47:52,560
Speaker 1: what I'm saying, or interest sisternally chuck, which is again

781
00:47:52,760 --> 00:47:54,560
Speaker 1: through the base of the skull in the back of

782
00:47:54,680 --> 00:47:58,120
Speaker 1: your head where your spinal cord goes into your up

783
00:47:58,160 --> 00:48:01,560
Speaker 1: to your brain. They and inject into your cerebro spinal

784
00:48:01,600 --> 00:48:04,600
Speaker 1: fluid like that too. It's probably the least fun of

785
00:48:04,640 --> 00:48:08,359
Speaker 1: all of them, but they are they're on the case

786
00:48:08,480 --> 00:48:12,120
Speaker 1: basically is what that means. Yeah, and you know we've

787
00:48:12,160 --> 00:48:14,440
Speaker 1: talked sort of off and on throughout this thing about

788
00:48:14,600 --> 00:48:18,239
Speaker 1: your quality of life with narcolepsy. Um, it's obviously a

789
00:48:18,320 --> 00:48:22,319
Speaker 1: serious thing. There can besides just like holding a job

790
00:48:22,760 --> 00:48:27,399
Speaker 1: and um, socially and not being depressed because you don't

791
00:48:27,400 --> 00:48:28,880
Speaker 1: want to hang out with people because you may be

792
00:48:28,920 --> 00:48:32,919
Speaker 1: embarrassed by it. Uh. There's also like the very real

793
00:48:33,120 --> 00:48:37,319
Speaker 1: chance of accidents. Um. Some people are not allowed to drive,

794
00:48:37,480 --> 00:48:39,960
Speaker 1: some people are allowed to drive. It kind of depends

795
00:48:40,040 --> 00:48:44,760
Speaker 1: on I guess your your diagnosis. Uh. School is tricky.

796
00:48:44,920 --> 00:48:48,120
Speaker 1: Work can be tricky. Although they do UM they do

797
00:48:48,320 --> 00:48:51,840
Speaker 1: with the Americans with Disabilities Act. They provide for letting

798
00:48:51,880 --> 00:48:53,879
Speaker 1: people take naps and stuff like that, which is kind

799
00:48:53,880 --> 00:48:57,040
Speaker 1: of cool. It is. Yeah, if you have narcolepsy and

800
00:48:57,440 --> 00:48:59,680
Speaker 1: um you're at work, you can say, hey, employer, I

801
00:48:59,760 --> 00:49:01,399
Speaker 1: need them, I need a place to take a nap,

802
00:49:02,320 --> 00:49:04,680
Speaker 1: and they'll say, okay, that's great, let's say right in here,

803
00:49:04,680 --> 00:49:08,600
Speaker 1: and they're like, oh my god, Chuck's in there, right, Chuck.

804
00:49:10,400 --> 00:49:12,600
Speaker 1: The there's I mean it gets even sadder though, like

805
00:49:12,719 --> 00:49:16,160
Speaker 1: there there are people who who um die by suicide

806
00:49:16,440 --> 00:49:20,800
Speaker 1: from uh narcolepsy. There was a girl named Katie Clack

807
00:49:21,400 --> 00:49:25,440
Speaker 1: who got pandem riics and developed narcolepsy as a result,

808
00:49:25,880 --> 00:49:29,000
Speaker 1: and she ended up taking her life, um because she

809
00:49:29,239 --> 00:49:32,759
Speaker 1: just it just completely derailed things for um. She was

810
00:49:32,800 --> 00:49:34,760
Speaker 1: in no way, shape or form prepared for it, although

811
00:49:35,120 --> 00:49:38,280
Speaker 1: I don't know that anybody's prepared for it. And then also,

812
00:49:38,440 --> 00:49:40,759
Speaker 1: like you were saying, an accident can happen, and from

813
00:49:40,800 --> 00:49:44,760
Speaker 1: what I read, um, the risk of death and injury

814
00:49:44,800 --> 00:49:48,680
Speaker 1: among people with narcolepsy is almost twice that of the

815
00:49:48,800 --> 00:49:52,880
Speaker 1: general population through things like car accidents or you know,

816
00:49:53,160 --> 00:49:55,960
Speaker 1: cooking or going up a ladder or something like that.

817
00:49:56,360 --> 00:49:59,360
Speaker 1: If you suddenly developed cataplexy or a sleep attack or

818
00:49:59,400 --> 00:50:02,200
Speaker 1: something that's that's a bad time to fall asleep or

819
00:50:02,280 --> 00:50:04,719
Speaker 1: lose control of your muscles. You know. Well, and at

820
00:50:04,719 --> 00:50:07,480
Speaker 1: the very least you're gonna have to really arrange your

821
00:50:07,560 --> 00:50:11,720
Speaker 1: life to accommodate for this stuff, right, you know. But again,

822
00:50:11,920 --> 00:50:15,279
Speaker 1: if you are managing your symptoms, you can you can

823
00:50:15,440 --> 00:50:18,000
Speaker 1: lead a pretty normal life. I think it's just a

824
00:50:18,120 --> 00:50:23,600
Speaker 1: question of like getting diagnosed correctly. Yeah, well that's it

825
00:50:23,719 --> 00:50:26,400
Speaker 1: for ourclepsy. Hopefully we'll have it all figured out, and

826
00:50:26,440 --> 00:50:28,680
Speaker 1: when we revisit it in five or ten years will

827
00:50:28,680 --> 00:50:33,160
Speaker 1: be like it was all right, Everything was correct, it

828
00:50:33,280 --> 00:50:36,440
Speaker 1: was all right. And since I said it was all right,

829
00:50:36,640 --> 00:50:42,239
Speaker 1: it's time for listener, mate, I'm gonna call this soul

830
00:50:42,280 --> 00:50:46,320
Speaker 1: Train feedback. That was a fun show, and this is

831
00:50:46,360 --> 00:50:51,120
Speaker 1: from Julia. Hello, guys, we really enjoyed your Soul Train episode.

832
00:50:51,280 --> 00:50:54,240
Speaker 1: You did a great job capturing the feeling and cultural

833
00:50:54,320 --> 00:50:58,600
Speaker 1: significance of the show. You depicted a brilliant, flawed Don

834
00:50:58,680 --> 00:51:03,600
Speaker 1: Cornelius without gating his profound contribution. There was a monthly

835
00:51:03,680 --> 00:51:07,680
Speaker 1: black teenage magazine named right on. This publication gave names

836
00:51:07,719 --> 00:51:10,879
Speaker 1: to the dances and dancers. We would read the ink

837
00:51:11,000 --> 00:51:14,360
Speaker 1: off of the pages. Being black in America then and

838
00:51:14,480 --> 00:51:19,440
Speaker 1: now we watch mainstream America love the culture while devaluing

839
00:51:19,480 --> 00:51:23,480
Speaker 1: the people and criminalizing the young. Thank you for this episode.

840
00:51:23,880 --> 00:51:26,880
Speaker 1: And that is from Julia Pierce, the president of the

841
00:51:27,000 --> 00:51:31,520
Speaker 1: Tybee MLK Human Rights Committee. Nice Tybee Island. I guess

842
00:51:31,560 --> 00:51:34,120
Speaker 1: down in Georgia. I don't know, I guess so I hope.

843
00:51:34,160 --> 00:51:38,040
Speaker 1: So that's great. Thanks a lot, Julia, I much appreciated. Agreed.

844
00:51:39,040 --> 00:51:40,279
Speaker 1: If you want to get in touch with this like

845
00:51:40,440 --> 00:51:44,160
Speaker 1: Julia did. Give us props, or just say hey, you

846
00:51:44,239 --> 00:51:47,239
Speaker 1: guys are doing this too much, or be quiet. Well,

847
00:51:47,440 --> 00:51:49,840
Speaker 1: we never will, but you can still say it. You

848
00:51:49,880 --> 00:51:52,640
Speaker 1: can send us an email to stuff podcast did i

849
00:51:52,760 --> 00:51:58,640
Speaker 1: heeart radio dot com. Stuff you Should Know is a

850
00:51:58,640 --> 00:52:01,200
Speaker 1: production of I Heart Radios How stuff Works. For more

851
00:52:01,239 --> 00:52:03,680
Speaker 1: podcasts for my heart Radio, visit the I Heart Radio app,

852
00:52:03,760 --> 00:52:06,360
Speaker 1: Apple Podcasts, or wherever you listen to your favorite shows.

853
00:52:09,520 --> 00:52:09,560
Speaker 1: H