1 00:00:02,720 --> 00:00:14,000 Speaker 1: Bloomberg Audio Studios, Podcasts, Radio News. 2 00:00:18,040 --> 00:00:21,040 Speaker 2: Hello and welcome to another episode of the Authoughts podcast. 3 00:00:21,160 --> 00:00:22,720 Speaker 3: I'm Tracy Alloway and I'm Joe. 4 00:00:22,920 --> 00:00:24,080 Speaker 4: Isn't Joe? 5 00:00:24,480 --> 00:00:25,560 Speaker 3: I have a present for you? 6 00:00:26,040 --> 00:00:27,680 Speaker 4: Okay, I'm excited. 7 00:00:27,840 --> 00:00:30,560 Speaker 3: It's December tenth. Yeah, Christmas is. 8 00:00:33,240 --> 00:00:33,440 Speaker 2: Here. 9 00:00:33,440 --> 00:00:33,760 Speaker 3: You go. 10 00:00:34,400 --> 00:00:39,800 Speaker 4: Let me see what is this? Okay, quality qualitysprays dot 11 00:00:39,840 --> 00:00:45,280 Speaker 4: com and it's a Hey, it seems like an illegal drug, oxytocin. 12 00:00:45,520 --> 00:00:47,360 Speaker 3: It's not illegal. It's not illegal. 13 00:00:47,479 --> 00:00:50,640 Speaker 2: I got it off Amazon for like sixty oxytocin. 14 00:00:51,159 --> 00:00:52,839 Speaker 4: That sounds illegal, it's not. 15 00:00:53,159 --> 00:00:56,360 Speaker 2: Okay, do you know what oxytocin actually is? 16 00:00:56,400 --> 00:00:57,760 Speaker 4: I'm sure it's really bad. 17 00:00:57,960 --> 00:00:59,040 Speaker 3: It's a peptide. 18 00:00:59,160 --> 00:01:02,080 Speaker 4: Okay, I don't know that. Yeah, I actually don't even 19 00:01:02,120 --> 00:01:04,240 Speaker 4: know what a peptide is. I've been hearing this word peptide. 20 00:01:04,240 --> 00:01:07,640 Speaker 4: I don't know what classification of chemical or molecule chain 21 00:01:07,720 --> 00:01:10,280 Speaker 4: or anything a peptide is. But I've been hearing about 22 00:01:10,319 --> 00:01:11,560 Speaker 4: this word peptide more and more. 23 00:01:11,720 --> 00:01:12,520 Speaker 3: This is important. 24 00:01:12,840 --> 00:01:14,240 Speaker 4: You're actually gonna give this a mirror? Is this just 25 00:01:14,280 --> 00:01:14,959 Speaker 4: a prop that I've done? 26 00:01:14,959 --> 00:01:16,880 Speaker 2: It's just a prop, Okay, And I just said that 27 00:01:16,880 --> 00:01:20,240 Speaker 2: that it's yours. But it's actually mine. Okay, peptides. Peptides 28 00:01:20,280 --> 00:01:22,800 Speaker 2: aren't the P in glp ones. 29 00:01:22,959 --> 00:01:26,000 Speaker 4: Oh so I think I do. Yeah, I think I 30 00:01:26,040 --> 00:01:28,360 Speaker 4: knew gop ones was a peptide, but I still don't 31 00:01:28,360 --> 00:01:29,600 Speaker 4: know what is it anyway. 32 00:01:29,360 --> 00:01:29,679 Speaker 5: All right. 33 00:01:30,040 --> 00:01:32,800 Speaker 2: The reason you're hearing about it a lot is because 34 00:01:33,440 --> 00:01:35,520 Speaker 2: a lot of people seem to be using them in 35 00:01:35,600 --> 00:01:38,280 Speaker 2: various ways. And there are all these different types of 36 00:01:38,280 --> 00:01:42,640 Speaker 2: peptides that supposedly do different things for the body. This 37 00:01:42,720 --> 00:01:49,000 Speaker 2: one apparently makes you better at eye contact and more sociable. 38 00:01:49,560 --> 00:01:52,400 Speaker 4: So really funny. Back when I was in I could 39 00:01:52,440 --> 00:01:54,680 Speaker 4: have used this, like twenty five years ago. When I 40 00:01:54,720 --> 00:01:58,600 Speaker 4: was younger, like in college. It didn't happen very often, 41 00:01:58,640 --> 00:02:02,680 Speaker 4: but I occasionally went on a few days and very rare, 42 00:02:02,800 --> 00:02:05,320 Speaker 4: very rare. I'm not going to say anything, very rare occurrence. 43 00:02:05,800 --> 00:02:07,920 Speaker 4: But one of the things I would notice if I 44 00:02:07,960 --> 00:02:10,440 Speaker 4: was out on a date and like the girl would 45 00:02:10,520 --> 00:02:13,320 Speaker 4: start like messing with like her hair a little bit. 46 00:02:13,440 --> 00:02:15,760 Speaker 4: She likes you, no, and she's like, if there's something 47 00:02:16,160 --> 00:02:18,760 Speaker 4: wrong with my hair because you keep looking like three 48 00:02:18,760 --> 00:02:21,080 Speaker 4: inches above my eyes and I'm like no, I'm just 49 00:02:21,160 --> 00:02:23,799 Speaker 4: very awkward. It's very difficult for me, and she's like, oh. 50 00:02:24,040 --> 00:02:25,920 Speaker 4: I was like, it's very awkward for me and not 51 00:02:26,040 --> 00:02:28,280 Speaker 4: very good at eye contact and so forth, And so 52 00:02:28,360 --> 00:02:30,160 Speaker 4: I just assumed it was something in my hair that 53 00:02:30,280 --> 00:02:32,560 Speaker 4: I was like trying to get out. And I was like, no, 54 00:02:32,680 --> 00:02:33,600 Speaker 4: I'm sorry, I'm. 55 00:02:33,480 --> 00:02:35,200 Speaker 3: Just like this, this happened to you more than once. 56 00:02:35,760 --> 00:02:39,640 Speaker 4: Yes, So I could have really used a chemical that 57 00:02:39,680 --> 00:02:41,960 Speaker 4: would solve the eye contact problem. Now I've grown up, 58 00:02:42,000 --> 00:02:43,359 Speaker 4: I've grown out of it. I can look someone in 59 00:02:43,440 --> 00:02:43,920 Speaker 4: the eye. 60 00:02:43,720 --> 00:02:46,120 Speaker 2: Now, I will say I have tested it. I'm not 61 00:02:46,320 --> 00:02:49,280 Speaker 2: entirely convinced of its effects. But you know, in the 62 00:02:49,360 --> 00:02:52,400 Speaker 2: name of science, for all thoughts, I have been a 63 00:02:52,440 --> 00:02:52,959 Speaker 2: guinea pig. 64 00:02:53,120 --> 00:02:56,040 Speaker 4: So we know GLP ones whatever they're called, we goovi 65 00:02:56,200 --> 00:02:59,080 Speaker 4: and all those those are good for weight loss, and 66 00:02:59,120 --> 00:03:01,720 Speaker 4: we know it's almost a miracle drug, right, everyone's like incredible. 67 00:03:01,760 --> 00:03:05,000 Speaker 4: But in theory, there are other peptides out there that 68 00:03:05,160 --> 00:03:09,560 Speaker 4: could be equivalently miraculous. We just don't really know about them, 69 00:03:09,600 --> 00:03:13,240 Speaker 4: and maybe they're not sort of medicinalized the way that 70 00:03:13,320 --> 00:03:14,160 Speaker 4: the weight loss ones are. 71 00:03:14,320 --> 00:03:18,160 Speaker 2: Yeah, and also not distributed the same way as GLP 72 00:03:18,480 --> 00:03:21,240 Speaker 2: ones in America. And we're going to get all into 73 00:03:21,280 --> 00:03:25,880 Speaker 2: that because it's actually a really interesting topic, both culturally 74 00:03:26,160 --> 00:03:30,080 Speaker 2: and from a supply chain perspective, and we love supply chains, 75 00:03:30,160 --> 00:03:32,160 Speaker 2: so we love supply chains all right. 76 00:03:32,240 --> 00:03:33,480 Speaker 3: So for this. 77 00:03:33,560 --> 00:03:36,920 Speaker 2: Particular topic, we're actually going to have two guests, great 78 00:03:37,240 --> 00:03:40,400 Speaker 2: because it's so interesting and I got so into. 79 00:03:40,440 --> 00:03:41,480 Speaker 3: The peptide world. 80 00:03:41,680 --> 00:03:45,000 Speaker 2: Our first guest is Jasmine's son. She has an independent 81 00:03:45,040 --> 00:03:48,600 Speaker 2: writer covering AI and San Francisco culture, and this is 82 00:03:48,720 --> 00:03:53,160 Speaker 2: definitely a San Francisco cultural thing. So Jasmine, you are 83 00:03:53,160 --> 00:03:55,440 Speaker 2: truly the perfect guest. Thank you so much for coming on. 84 00:03:55,400 --> 00:03:57,640 Speaker 6: All thoughts, I am so excited to be here. 85 00:03:58,520 --> 00:04:01,040 Speaker 2: So first of all, well, why don't you just tell 86 00:04:01,120 --> 00:04:04,400 Speaker 2: us a little bit more about what peptides actually are 87 00:04:04,640 --> 00:04:07,160 Speaker 2: and how they first came onto your radar screen? 88 00:04:07,600 --> 00:04:11,160 Speaker 6: Right? So, peptides are basically short chains of amino acids. 89 00:04:11,200 --> 00:04:14,080 Speaker 6: They are the building blocks proteins. There are peptides that 90 00:04:14,080 --> 00:04:16,799 Speaker 6: are naturally occurring in the human body, so for example, 91 00:04:16,880 --> 00:04:20,040 Speaker 6: oxytocin like you have right there, we produce it during 92 00:04:20,120 --> 00:04:23,080 Speaker 6: pregnancy when you hug somebody, hug your partner, hug your 93 00:04:23,080 --> 00:04:26,760 Speaker 6: family member. But there are also synthetic peptides that are 94 00:04:27,040 --> 00:04:29,880 Speaker 6: manufactured in labs or people can take these peptides that 95 00:04:29,920 --> 00:04:32,839 Speaker 6: already exist in the human body and inject extra of 96 00:04:32,880 --> 00:04:35,720 Speaker 6: it if your body, say, doesn't produce enough. So insulin, 97 00:04:35,760 --> 00:04:37,960 Speaker 6: for example, is an example of a peptide that's been 98 00:04:38,080 --> 00:04:41,279 Speaker 6: used obviously for to treat diabetics for a very long time. 99 00:04:41,560 --> 00:04:43,680 Speaker 6: So peptides are actually a very broad class of drugs. 100 00:04:43,680 --> 00:04:47,080 Speaker 6: But I think the interest in more experimental peptides and 101 00:04:47,600 --> 00:04:51,919 Speaker 6: within biohacking communities and things like that has really exploded 102 00:04:51,960 --> 00:04:55,279 Speaker 6: in recent years. I would trace it to basically the 103 00:04:55,520 --> 00:04:58,479 Speaker 6: boom in GLP one use. A lot of folks who 104 00:04:58,600 --> 00:05:00,800 Speaker 6: I spoke to over the past few weeks who have 105 00:05:00,839 --> 00:05:05,000 Speaker 6: been experimenting with peptides and injecting them themselves, first started 106 00:05:05,080 --> 00:05:08,040 Speaker 6: getting comfortable with even the idea of injections, which were 107 00:05:08,080 --> 00:05:10,839 Speaker 6: previously seen as a bit intense for people. 108 00:05:10,920 --> 00:05:16,000 Speaker 2: Yeah, you're injecting yourself with drugs. That has right connotations, right. 109 00:05:15,920 --> 00:05:17,919 Speaker 6: But I think that golp ones in a zembic and 110 00:05:17,960 --> 00:05:21,480 Speaker 6: WGOV were what really popularized it and made people comfortable. 111 00:05:21,800 --> 00:05:23,919 Speaker 6: So it first came on my radar aside from the 112 00:05:23,960 --> 00:05:27,479 Speaker 6: GOLP story, because I started seeing tweets that I'm sure 113 00:05:27,520 --> 00:05:30,880 Speaker 6: you guys have seen two all over usftech Twitter about 114 00:05:30,880 --> 00:05:34,320 Speaker 6: how everybody has a Chinese peptid dealer. Now, I thought 115 00:05:34,320 --> 00:05:36,760 Speaker 6: this was kind of a joke until I started mentioning 116 00:05:36,800 --> 00:05:39,640 Speaker 6: it in conversations and I realized that my friends were 117 00:05:39,680 --> 00:05:42,479 Speaker 6: on Chinese peptides. They were like, wait, Jasmine, are you 118 00:05:42,520 --> 00:05:44,719 Speaker 6: not on these? They're amazing. I got to get you 119 00:05:44,760 --> 00:05:47,120 Speaker 6: on these peptides. I got a dealer, I got my guy, 120 00:05:47,480 --> 00:05:49,640 Speaker 6: and I'm like, what are you on about? And I 121 00:05:49,680 --> 00:05:52,040 Speaker 6: think the first one that I heard about people using, 122 00:05:52,279 --> 00:05:54,720 Speaker 6: which is the most popular that I have since heard, 123 00:05:54,800 --> 00:05:56,680 Speaker 6: is read A True Tide, which is what some people 124 00:05:56,720 --> 00:06:00,200 Speaker 6: call a GLP three. So basically, GOLP ones are through 125 00:06:00,200 --> 00:06:03,040 Speaker 6: the FDA process. People are like something like twelve percent 126 00:06:03,040 --> 00:06:04,920 Speaker 6: of Americans depending on what survey you look at, are 127 00:06:05,000 --> 00:06:08,240 Speaker 6: using them. But there are now next generation weight loss 128 00:06:08,279 --> 00:06:11,400 Speaker 6: drugs that work on not just the GLP one receptors, 129 00:06:11,440 --> 00:06:14,599 Speaker 6: but also the GP receptors and the glougle on receptors 130 00:06:14,640 --> 00:06:17,920 Speaker 6: to encourage even faster weight loss. And these GLP threes 131 00:06:18,040 --> 00:06:19,840 Speaker 6: like redd A True Tide, are still in phase two 132 00:06:19,880 --> 00:06:23,000 Speaker 6: clinical trials. But because people have been watching this space, 133 00:06:23,279 --> 00:06:26,640 Speaker 6: they're seeing really good results in those clinical trials. Some 134 00:06:26,680 --> 00:06:29,120 Speaker 6: folks have thought, Okay, let me go straight to the source. 135 00:06:29,279 --> 00:06:32,599 Speaker 6: I'm going to find a Chinese manufacturer that makes red 136 00:06:32,600 --> 00:06:34,920 Speaker 6: a true tide for cheap and I will import them 137 00:06:34,960 --> 00:06:37,440 Speaker 6: at a low cost of maybe one hundred bucks two 138 00:06:37,480 --> 00:06:39,839 Speaker 6: hundred bucks a month from one of these gray market 139 00:06:39,880 --> 00:06:43,000 Speaker 6: suppliers and using myself for weight loss for one fifth 140 00:06:43,000 --> 00:06:45,840 Speaker 6: of the costs that I was getting my prescription ozempicat 141 00:06:45,920 --> 00:06:46,599 Speaker 6: or something like that. 142 00:06:46,720 --> 00:06:48,520 Speaker 3: I promised you this was a supply chage. 143 00:06:48,640 --> 00:06:53,120 Speaker 4: Yeah. No, obviously you want to talk more about peptides. 144 00:06:53,160 --> 00:06:54,720 Speaker 4: That's what we're here talking about. But I actually do 145 00:06:54,800 --> 00:06:56,800 Speaker 4: want to back up one second, because you're a San 146 00:06:56,839 --> 00:07:00,440 Speaker 4: Francisco culture reporter, among other things, and you write great 147 00:07:00,440 --> 00:07:03,280 Speaker 4: stuff about AI and communication all that stuff. One thing 148 00:07:03,320 --> 00:07:06,919 Speaker 4: I think about a lot these days is that we 149 00:07:07,080 --> 00:07:10,200 Speaker 4: all know that people in San Francisco really have a 150 00:07:10,280 --> 00:07:12,440 Speaker 4: very big influence on all of our lives, right because 151 00:07:12,440 --> 00:07:16,440 Speaker 4: they design the digital products that essentially constitute what makes 152 00:07:16,480 --> 00:07:19,840 Speaker 4: modern living distinct. But one thing I feel like and 153 00:07:20,480 --> 00:07:24,000 Speaker 4: a struggle an I articulate this all of these other 154 00:07:24,120 --> 00:07:27,160 Speaker 4: things that are part of the contemporary San Francisco lifestyle, 155 00:07:27,640 --> 00:07:31,960 Speaker 4: whether it's sort of like believing in AI doom scenarios, etc. 156 00:07:32,320 --> 00:07:35,720 Speaker 4: It's like weird cults that they form. Like to some extent, 157 00:07:35,840 --> 00:07:38,360 Speaker 4: this is such an important beat that you're on because 158 00:07:38,640 --> 00:07:42,000 Speaker 4: we are all living in the shadows of what has 159 00:07:42,080 --> 00:07:45,160 Speaker 4: going on in these people's brains, right, Like these ideas 160 00:07:45,160 --> 00:07:48,200 Speaker 4: that they think about body hacking and so forth, they 161 00:07:48,320 --> 00:07:52,000 Speaker 4: become the sort of like consumer products and so forth 162 00:07:52,200 --> 00:07:55,960 Speaker 4: that everyone just sort of uses without ever thinking about 163 00:07:56,000 --> 00:07:59,960 Speaker 4: like some of the philosophical gestalt behind it all. 164 00:08:00,360 --> 00:08:02,400 Speaker 6: Totally I mean, I think that's totally right. That's why 165 00:08:02,440 --> 00:08:05,080 Speaker 6: I love the San Francisco b I sort of collapse 166 00:08:05,160 --> 00:08:07,400 Speaker 6: it too, Like honestly, I just report on San Francisco, 167 00:08:07,520 --> 00:08:09,800 Speaker 6: whether that is. You know, in the beginning of twenty 168 00:08:09,840 --> 00:08:11,920 Speaker 6: twenty five, a lot of it was about the young tech, right, 169 00:08:12,240 --> 00:08:14,880 Speaker 6: and why did that happen? It's about AI. All the 170 00:08:14,880 --> 00:08:18,240 Speaker 6: weird sub ideologies, from AI doom to the successionists who 171 00:08:18,280 --> 00:08:20,480 Speaker 6: actually think that AI has a moral duty to replace 172 00:08:20,520 --> 00:08:23,240 Speaker 6: the human species because they're superior to us. There are 173 00:08:23,240 --> 00:08:25,480 Speaker 6: all these weird strains of thought, and I think ESAF, 174 00:08:25,600 --> 00:08:28,880 Speaker 6: especially this year, increasingly prides itself on sort of being 175 00:08:28,920 --> 00:08:30,960 Speaker 6: the place where the future comes first. They've sort of 176 00:08:31,240 --> 00:08:33,520 Speaker 6: re embraced that identity of like we're going to have 177 00:08:33,640 --> 00:08:36,520 Speaker 6: funerals for AI models that we missed. We are embracing 178 00:08:36,679 --> 00:08:41,720 Speaker 6: robotaxi abundance with Tesla Robotaxis and Zox's and Waymos, and 179 00:08:41,840 --> 00:08:43,720 Speaker 6: we're going to be the ones to trial the stuffers. 180 00:08:43,800 --> 00:08:46,400 Speaker 6: I'm going to a peptide rave this Saturday with a 181 00:08:46,440 --> 00:08:47,840 Speaker 6: cyberpunk dress code. 182 00:08:48,559 --> 00:08:50,439 Speaker 3: Sounds very there's. 183 00:08:50,280 --> 00:08:53,240 Speaker 6: A lot, it's very San Francisco. There are underground robot 184 00:08:53,240 --> 00:08:55,080 Speaker 6: bites that I'm sure you guys have seen videos of, 185 00:08:55,280 --> 00:08:57,880 Speaker 6: But I think San Francisco is really leaning into its 186 00:08:57,920 --> 00:09:00,880 Speaker 6: identity these days of weird kind of going to be 187 00:09:00,920 --> 00:09:03,920 Speaker 6: the place that is not sort of suffering under the 188 00:09:04,040 --> 00:09:07,959 Speaker 6: regulatory decelerationist burden that that's plaguing the rest of the 189 00:09:08,000 --> 00:09:10,400 Speaker 6: Western world. And we're going to embrace the frontier. And 190 00:09:10,440 --> 00:09:12,280 Speaker 6: I think peptides are part of that. It's a signaling 191 00:09:12,320 --> 00:09:13,400 Speaker 6: thing as much as health thing. 192 00:09:13,760 --> 00:09:17,440 Speaker 2: Well, okay, speaking of the tech community, is it true 193 00:09:17,480 --> 00:09:21,720 Speaker 2: that something like oxytocin it actually improves your eye contact? 194 00:09:21,720 --> 00:09:22,760 Speaker 3: And the way I heard. 195 00:09:22,600 --> 00:09:26,559 Speaker 2: It was this could be helpful for people who are 196 00:09:26,600 --> 00:09:29,400 Speaker 2: in tech, And yeah, maybe aren't that sociable? 197 00:09:30,120 --> 00:09:30,680 Speaker 6: Oh my god. 198 00:09:30,920 --> 00:09:31,120 Speaker 2: Yeah. 199 00:09:31,160 --> 00:09:35,200 Speaker 6: So the oxytocin is the only peptide that I've personally tried. 200 00:09:35,559 --> 00:09:37,920 Speaker 6: I think I first heard about it because Will Deepew, 201 00:09:37,960 --> 00:09:41,160 Speaker 6: who's like a young AI researcher open AI, tweeted about 202 00:09:41,160 --> 00:09:44,560 Speaker 6: it as I think nasal oxytocin is going to be 203 00:09:44,640 --> 00:09:50,080 Speaker 6: ozebic for autism, an incredible line like what the like, 204 00:09:50,120 --> 00:09:51,800 Speaker 6: what the hell is this? And it's been tested on 205 00:09:51,840 --> 00:09:54,600 Speaker 6: people with aspergers to help improve again those feelings of 206 00:09:54,880 --> 00:09:57,800 Speaker 6: social connection, empathy, warmth that comes as a nail spray 207 00:09:57,800 --> 00:10:00,000 Speaker 6: you can get for fifty bucks, sixty bucks off Amazon 208 00:10:00,160 --> 00:10:03,439 Speaker 6: or something. So I also like you, Tracy. When I 209 00:10:03,480 --> 00:10:06,320 Speaker 6: tried it, I didn't think it worked, but my friends 210 00:10:06,320 --> 00:10:09,079 Speaker 6: did insist that I was a little bit friendlier than 211 00:10:09,080 --> 00:10:11,800 Speaker 6: I normally am, and I was in fact making more 212 00:10:11,800 --> 00:10:12,520 Speaker 6: eye contacts. 213 00:10:12,559 --> 00:10:13,719 Speaker 3: So we're going to have to do that. 214 00:10:13,840 --> 00:10:16,920 Speaker 2: I thought some experiments here at all thoughts, and just 215 00:10:16,960 --> 00:10:19,440 Speaker 2: have a bunch of conversations where we're on and off 216 00:10:19,480 --> 00:10:20,239 Speaker 2: the oxytocin. 217 00:10:20,360 --> 00:10:21,160 Speaker 3: Ye, see what happens we. 218 00:10:21,200 --> 00:10:25,319 Speaker 4: Got to I really could have used that in college 219 00:10:25,440 --> 00:10:28,120 Speaker 4: for sure. So there's all kinds of ones, right, So okay, 220 00:10:28,280 --> 00:10:31,679 Speaker 4: JP one's weight laws. This one supposedly helps you with 221 00:10:31,800 --> 00:10:35,160 Speaker 4: eye contact and connection. What are some of the other 222 00:10:35,760 --> 00:10:38,640 Speaker 4: things that people are using peptides for? 223 00:10:39,400 --> 00:10:41,760 Speaker 6: So aside from the GLP ones and the GLP threes, 224 00:10:41,800 --> 00:10:45,120 Speaker 6: which are the most popular, there are all sorts of peptides. 225 00:10:45,160 --> 00:10:48,240 Speaker 6: They are a really really broad class of chemical. So 226 00:10:48,400 --> 00:10:51,440 Speaker 6: the most popular other than that is BPC one five seven, 227 00:10:51,520 --> 00:10:54,880 Speaker 6: which supposedly helps with muscle healing and regeneration so after 228 00:10:54,920 --> 00:10:58,440 Speaker 6: a really hard workout. That one has been experimented with 229 00:10:58,520 --> 00:11:02,160 Speaker 6: in bodybuilding communities for many years. So there's all these 230 00:11:02,280 --> 00:11:05,240 Speaker 6: crazy bodybuilding forums where people are playing with this stuff 231 00:11:05,320 --> 00:11:08,920 Speaker 6: and human growth hormone and things like that. There is melanotan, 232 00:11:09,000 --> 00:11:13,000 Speaker 6: which supposedly increases melanin production in the skin. So I 233 00:11:13,080 --> 00:11:17,000 Speaker 6: talked to a founder a CEO of a unicorn logistics 234 00:11:17,000 --> 00:11:20,200 Speaker 6: company who told me that his first peptide was melanotan 235 00:11:20,280 --> 00:11:22,840 Speaker 6: because he hated being a ginger. He had always wanted 236 00:11:22,840 --> 00:11:25,280 Speaker 6: to stop being a ginger, so he cured it by 237 00:11:25,320 --> 00:11:28,200 Speaker 6: taking this thing that increases your melanin production. It makes 238 00:11:28,200 --> 00:11:31,040 Speaker 6: you tanner. Another person described it to me as the hot, 239 00:11:31,080 --> 00:11:34,839 Speaker 6: horny and tan peptide, so that one for the those 240 00:11:34,840 --> 00:11:37,120 Speaker 6: who aren't getting enough sunlight shut in in an office. 241 00:11:37,120 --> 00:11:40,600 Speaker 6: Maybe that's your pick. There is epitellon which folks have 242 00:11:40,640 --> 00:11:44,520 Speaker 6: credited with increasing improving their sleep, their cimax, which people 243 00:11:44,520 --> 00:11:47,520 Speaker 6: believe helps with their anxiety. To be clear, most of 244 00:11:47,520 --> 00:11:50,240 Speaker 6: the peptides, aside from the glps, have not been in 245 00:11:50,320 --> 00:11:52,800 Speaker 6: any human trials whatsoever, So a lot of this sort 246 00:11:52,840 --> 00:11:56,480 Speaker 6: of comes from anecdotal evidence in people experimenting rather than 247 00:11:56,559 --> 00:12:00,360 Speaker 6: from like FDA proved or like RCTs, and some of 248 00:12:00,400 --> 00:12:03,240 Speaker 6: these you know, only have animal trials or cell culture 249 00:12:03,400 --> 00:12:04,600 Speaker 6: in vitro tests. 250 00:12:04,920 --> 00:12:07,120 Speaker 2: Yeah, I wanted to ask you about this actually, because 251 00:12:07,200 --> 00:12:12,360 Speaker 2: my impression is peptides like there's not much profit to 252 00:12:12,480 --> 00:12:15,280 Speaker 2: be made from them for the pharma companies, and so 253 00:12:15,320 --> 00:12:18,520 Speaker 2: it's just not worth it to them to actually test 254 00:12:18,720 --> 00:12:22,719 Speaker 2: on humans, and yet they're still commercially available. 255 00:12:23,559 --> 00:12:25,920 Speaker 6: That is one of the stories I heard, because you know, 256 00:12:26,040 --> 00:12:29,240 Speaker 6: I asked, well, GLP ones have been so profitable, so like, 257 00:12:29,679 --> 00:12:33,440 Speaker 6: why aren't people trying to push through FDA trials these 258 00:12:33,480 --> 00:12:37,720 Speaker 6: other peptides that people have been crediting with like transformative 259 00:12:37,720 --> 00:12:40,280 Speaker 6: health improvements or whatever. And the story I heard is 260 00:12:40,280 --> 00:12:43,800 Speaker 6: that because peptides are these very small, very basic chains. 261 00:12:44,040 --> 00:12:47,040 Speaker 6: They're too commoditized. Basically, like at the point where these 262 00:12:47,160 --> 00:12:50,480 Speaker 6: Chinese factories are able to without a ton of like 263 00:12:50,559 --> 00:12:55,360 Speaker 6: extremely advanced scientific knowledge, be able to manufacture them on masks, 264 00:12:55,760 --> 00:12:57,800 Speaker 6: no company is going to want to invest like one 265 00:12:57,880 --> 00:13:00,959 Speaker 6: hundred million and a billion dollars in getting it through 266 00:13:01,040 --> 00:13:04,280 Speaker 6: the like excruciating FDA trial process, And so that sort 267 00:13:04,320 --> 00:13:07,440 Speaker 6: of left peptides in this gray market environment where people 268 00:13:07,480 --> 00:13:10,199 Speaker 6: are saying, like, okay, like I might as well go 269 00:13:10,600 --> 00:13:12,680 Speaker 6: import the stuff from China and maybe get it purity 270 00:13:12,720 --> 00:13:15,040 Speaker 6: tested myself. It's going to cost a few hundred dollars 271 00:13:15,040 --> 00:13:16,679 Speaker 6: in total, and let's just. 272 00:13:16,640 --> 00:13:20,520 Speaker 4: See, Yeah, let's talk about that, because I don't love 273 00:13:20,559 --> 00:13:23,880 Speaker 4: the idea of sticking myself with needles. But then also 274 00:13:23,920 --> 00:13:26,839 Speaker 4: I don't love the idea of like sticking myself with 275 00:13:27,040 --> 00:13:30,839 Speaker 4: needles for some random thing that came from a factory. 276 00:13:30,600 --> 00:13:34,280 Speaker 2: Or having a dealer rights my thing. 277 00:13:34,400 --> 00:13:37,000 Speaker 4: And I want to get into the legal aspects of 278 00:13:37,120 --> 00:13:40,440 Speaker 4: all of this. Is well, but yeah, talk to us 279 00:13:40,480 --> 00:13:43,720 Speaker 4: about the I guess just the comfort that people have 280 00:13:44,320 --> 00:13:47,959 Speaker 4: with frankly injecting themselves with chemicals that they probably have 281 00:13:48,040 --> 00:13:49,800 Speaker 4: no idea what's in there, can't verify it, or I 282 00:13:49,840 --> 00:13:52,599 Speaker 4: have no idea how the quality of the lab and 283 00:13:52,679 --> 00:13:54,319 Speaker 4: China that they're getting them from. 284 00:13:54,960 --> 00:13:58,480 Speaker 6: Yeah, I mean so, I've interviewed probably a dozen plus 285 00:13:58,520 --> 00:14:02,000 Speaker 6: people peptide users in and around the tech community over 286 00:14:02,080 --> 00:14:05,080 Speaker 6: the past few weeks, and I will say that almost 287 00:14:05,080 --> 00:14:07,280 Speaker 6: everyone I spoke to, I'd ask like, Hey, are you scared? 288 00:14:07,320 --> 00:14:09,120 Speaker 6: Are you worried? Do you have to like get over 289 00:14:09,280 --> 00:14:12,120 Speaker 6: a mental hump with the stuff, And most of them 290 00:14:12,160 --> 00:14:13,880 Speaker 6: would tell me, you know what, like I have a 291 00:14:13,960 --> 00:14:16,400 Speaker 6: higher risk tolerance in most people. I think this is 292 00:14:16,400 --> 00:14:20,000 Speaker 6: something that say startup founders in particular, really pride themselves on. 293 00:14:20,080 --> 00:14:22,800 Speaker 6: And a lot of these people were startup founders, right, 294 00:14:22,880 --> 00:14:25,760 Speaker 6: they think I'm the kind of person who is willing 295 00:14:25,800 --> 00:14:28,960 Speaker 6: to take risks. I'm the kind of person who doesn't 296 00:14:29,000 --> 00:14:31,800 Speaker 6: really need to wait until I'm given permission to do something, 297 00:14:31,840 --> 00:14:34,920 Speaker 6: whether that's by a regulator buy some boss. I can 298 00:14:34,960 --> 00:14:38,040 Speaker 6: sort of study up in my own way and that's 299 00:14:38,200 --> 00:14:41,480 Speaker 6: good enough. So I think people were surprisingly, they were 300 00:14:41,560 --> 00:14:43,880 Speaker 6: very comfortable telling me there is some risk. I know 301 00:14:44,000 --> 00:14:46,440 Speaker 6: that there have been some negative side effects, but you 302 00:14:46,480 --> 00:14:48,280 Speaker 6: know what, I keep a journal every day I have 303 00:14:48,360 --> 00:14:51,120 Speaker 6: friends who have used it. I'm going to suppliers that 304 00:14:51,200 --> 00:14:55,520 Speaker 6: are showing their testing certifications from top peptide testing firms, 305 00:14:55,560 --> 00:14:57,640 Speaker 6: and that's good enough for me, even though I wouldn't 306 00:14:57,640 --> 00:14:59,880 Speaker 6: recommend that everybody do this. But you're right, Joe, this 307 00:14:59,920 --> 00:15:03,120 Speaker 6: is a legal gray area. Some people would even say 308 00:15:03,120 --> 00:15:06,400 Speaker 6: black market. So use of the vast majority of these peptides, 309 00:15:06,440 --> 00:15:11,240 Speaker 6: particularly the non glps, no human trials, no FDA approval, 310 00:15:11,480 --> 00:15:16,240 Speaker 6: whether for pharmaceutical use or for use in compounding pharmacies, 311 00:15:16,440 --> 00:15:19,840 Speaker 6: which glps have been somewhat approved for. What that means 312 00:15:19,920 --> 00:15:21,600 Speaker 6: is that it is in an a legal gray area 313 00:15:21,640 --> 00:15:24,160 Speaker 6: because they're also not on DEA lists, so they're also 314 00:15:24,240 --> 00:15:26,440 Speaker 6: not in the sort of illicit drug list. It's sort 315 00:15:26,480 --> 00:15:29,280 Speaker 6: of a we don't know. And so one funny thing 316 00:15:29,320 --> 00:15:32,440 Speaker 6: that people joke about is all of the vials for 317 00:15:32,600 --> 00:15:35,920 Speaker 6: these peptides will say for research use only, because. 318 00:15:35,760 --> 00:15:38,920 Speaker 3: Everyone's peptide research apparently. 319 00:15:38,600 --> 00:15:42,680 Speaker 6: Exactly so these Chinese manufacturers, what they are allowed to 320 00:15:42,720 --> 00:15:45,640 Speaker 6: do is to ship peptides around the world for research use, 321 00:15:45,720 --> 00:15:50,200 Speaker 6: for scientists, for medical researchers, for bioresearchers, and so as 322 00:15:50,280 --> 00:15:52,800 Speaker 6: long as you're not saying it's for human use, you 323 00:15:52,800 --> 00:15:56,840 Speaker 6: don't have to prove a certain level of purity standard. 324 00:15:56,880 --> 00:16:00,440 Speaker 6: You don't need necessarily a factory that follows cGMP proto calls, 325 00:16:00,560 --> 00:16:02,800 Speaker 6: which are an FD approval to know that a factory 326 00:16:02,800 --> 00:16:05,200 Speaker 6: meets certain quality standards. But again, research use has a 327 00:16:05,200 --> 00:16:08,520 Speaker 6: lower bar. So people are basically importing the peptides for 328 00:16:08,640 --> 00:16:11,000 Speaker 6: research use, and then what they'll sometimes do is then 329 00:16:11,040 --> 00:16:14,800 Speaker 6: ship it separately to purity testing firms. So there are 330 00:16:15,320 --> 00:16:17,800 Speaker 6: different ones that people trust and don't located in the US, 331 00:16:17,920 --> 00:16:20,480 Speaker 6: located in Europe. But they'll basically take their batch of 332 00:16:20,520 --> 00:16:23,000 Speaker 6: peptides that they got from the Chinese manufacturer, take a 333 00:16:23,000 --> 00:16:25,360 Speaker 6: few samples, ship them off to a testing site, get 334 00:16:25,360 --> 00:16:28,800 Speaker 6: a certification that it's pure, it's impure, and then they 335 00:16:28,840 --> 00:16:32,680 Speaker 6: will go mix them themselves. Certain suppliers will basically serve 336 00:16:32,680 --> 00:16:35,280 Speaker 6: as the American middlemen. They will be US based companies 337 00:16:35,560 --> 00:16:39,400 Speaker 6: that will negotiate with the Chinese factories themselves, sort of 338 00:16:39,400 --> 00:16:42,040 Speaker 6: figure out which ones are trusted by running purity tests 339 00:16:42,080 --> 00:16:44,440 Speaker 6: and like ten different Chinese factories, I find pick the 340 00:16:44,480 --> 00:16:46,320 Speaker 6: one that they trust the most and then sort of 341 00:16:46,320 --> 00:16:50,200 Speaker 6: offer their brands guarantee of running the purity testing process 342 00:16:50,240 --> 00:16:52,480 Speaker 6: for the US buyers, and so it really depends on 343 00:16:52,480 --> 00:16:55,720 Speaker 6: people's risk tolerance. I've spoken with people who are going 344 00:16:55,840 --> 00:16:59,640 Speaker 6: direct and literally just being in contact with the manufacturers themselves. 345 00:17:00,000 --> 00:17:02,280 Speaker 6: I've also spoken to people who have said, I'm willing 346 00:17:02,320 --> 00:17:05,520 Speaker 6: to use this US middleman supplier that my friends are 347 00:17:05,520 --> 00:17:07,800 Speaker 6: all using and say is legit and is providing these 348 00:17:07,840 --> 00:17:10,520 Speaker 6: tests and certifications, but I'm not going to go straight 349 00:17:10,520 --> 00:17:11,720 Speaker 6: to the factory. 350 00:17:11,720 --> 00:17:14,880 Speaker 2: Talk to us about the info sharing a little bit more, 351 00:17:14,960 --> 00:17:18,480 Speaker 2: because this is one aspect of the peptide community I 352 00:17:18,520 --> 00:17:20,600 Speaker 2: guess you would call it is everyone is sort of 353 00:17:20,680 --> 00:17:26,720 Speaker 2: sharing maybe their personal dealer, personal supplier, and also info 354 00:17:26,760 --> 00:17:29,360 Speaker 2: on their personal experience with efficacy. 355 00:17:30,680 --> 00:17:33,679 Speaker 6: Totally, I think the sort of epistemology of the space 356 00:17:33,800 --> 00:17:36,680 Speaker 6: is super interesting because it's very word of mouth based, 357 00:17:36,760 --> 00:17:38,639 Speaker 6: very anecdotal, and I think it is rooted in a 358 00:17:38,640 --> 00:17:42,359 Speaker 6: growing distrust of the medical establishment and established sources. So 359 00:17:42,359 --> 00:17:45,360 Speaker 6: people are sort of embracing this do your own research. 360 00:17:45,400 --> 00:17:48,840 Speaker 6: So I would say that quote unquote browoness influencers like 361 00:17:48,920 --> 00:17:53,120 Speaker 6: Joe Rogan or Andrew Huberman have both talked extensively about 362 00:17:53,200 --> 00:17:56,040 Speaker 6: these peptides, so there are very wide audiences, so followers 363 00:17:56,040 --> 00:17:58,560 Speaker 6: in those communities are learning about them. There's a lot 364 00:17:58,560 --> 00:18:02,200 Speaker 6: of word of mouth. For example, at Sortain gyms, trainers 365 00:18:02,240 --> 00:18:05,040 Speaker 6: and people who train together will be sharing their peptide sacks. 366 00:18:05,640 --> 00:18:07,560 Speaker 6: One of the folks who I spoke to learned about 367 00:18:07,560 --> 00:18:11,600 Speaker 6: the peptides at less Online, which is a rationalist conference 368 00:18:11,640 --> 00:18:14,919 Speaker 6: that happens every spring. There is a GLP one session 369 00:18:15,000 --> 00:18:18,000 Speaker 6: that she went to. She then discovered this person that 370 00:18:18,040 --> 00:18:20,359 Speaker 6: everybody else was on Red a True Tide instead, and 371 00:18:20,400 --> 00:18:22,960 Speaker 6: they all decided to tell her, Hey, we're all still alive, 372 00:18:23,000 --> 00:18:25,480 Speaker 6: so like, you should get on this. There's less Wrong 373 00:18:25,520 --> 00:18:29,080 Speaker 6: posts on the Rationalist forum describing people's day by day 374 00:18:29,119 --> 00:18:32,360 Speaker 6: experiences with peptides their amateur subsect blogs. They are very 375 00:18:32,400 --> 00:18:36,600 Speaker 6: shady telegram and discord groups where people are advertising their suppliers, 376 00:18:36,600 --> 00:18:39,480 Speaker 6: though honestly, I think I would not choose a supplier 377 00:18:39,520 --> 00:18:42,600 Speaker 6: off like a telegramm or discord group personally. But it 378 00:18:42,680 --> 00:18:44,400 Speaker 6: is kind of the wild West out there in terms 379 00:18:44,400 --> 00:18:47,520 Speaker 6: of information, and most people are really just going off 380 00:18:47,520 --> 00:18:49,439 Speaker 6: social proof and the people that they personally know. 381 00:18:50,040 --> 00:18:53,280 Speaker 4: You know, we did an episode a while back about adderall, 382 00:18:53,320 --> 00:18:55,600 Speaker 4: and of course a lot of people who are you know, 383 00:18:55,640 --> 00:18:57,800 Speaker 4: work in front of a computer, are field that they 384 00:18:57,800 --> 00:18:59,919 Speaker 4: can get some edge on adderall? Is there only a 385 00:19:00,119 --> 00:19:04,679 Speaker 4: level of competitiveness though in the culture such that you 386 00:19:04,760 --> 00:19:07,840 Speaker 4: feel like, look all their people are, maybe they're more 387 00:19:07,920 --> 00:19:11,520 Speaker 4: locked in, maybe they're better at office politics, or maybe 388 00:19:11,560 --> 00:19:14,560 Speaker 4: better at pitching a VC because totally they've got there 389 00:19:14,720 --> 00:19:17,440 Speaker 4: where people feel like they have to be on these 390 00:19:17,560 --> 00:19:20,360 Speaker 4: or they feel like they have to optimize their peptide 391 00:19:20,440 --> 00:19:24,080 Speaker 4: stack so that they can compete and sort of be 392 00:19:24,160 --> 00:19:25,240 Speaker 4: at their best. 393 00:19:25,560 --> 00:19:28,320 Speaker 6: Oh yeah, absolutely. I mean one of the YC founders 394 00:19:28,320 --> 00:19:30,800 Speaker 6: I talked to, she literally said, it's another thing I 395 00:19:30,800 --> 00:19:33,320 Speaker 6: can optimize, just like my SEO. She runs a SaaS 396 00:19:33,320 --> 00:19:36,920 Speaker 6: business that's her day job. Or another thing that somebody 397 00:19:37,000 --> 00:19:40,399 Speaker 6: in these communities told me is these people like sometimes 398 00:19:40,400 --> 00:19:42,200 Speaker 6: they're not overweight. In fact, a lot of the time 399 00:19:42,280 --> 00:19:44,880 Speaker 6: these folks are not actually overweight. And the reason they're 400 00:19:44,880 --> 00:19:46,600 Speaker 6: taking say bred a true tide or a weight less 401 00:19:46,600 --> 00:19:49,240 Speaker 6: peptide is because they want to eliminate the food noise 402 00:19:49,400 --> 00:19:51,159 Speaker 6: so they don't have to take a break for lunch. 403 00:19:51,320 --> 00:19:53,359 Speaker 6: They can just be locked in for sixteen hours straight, 404 00:19:53,520 --> 00:19:54,880 Speaker 6: or like, why do you have to go to the gym, 405 00:19:54,920 --> 00:19:57,080 Speaker 6: which is going to you know, drain your ability to 406 00:19:57,160 --> 00:19:59,800 Speaker 6: run a few more experiments or whatever when you could 407 00:19:59,800 --> 00:20:02,040 Speaker 6: just be taking one of these. And so I think 408 00:20:02,080 --> 00:20:04,840 Speaker 6: there is a lot of this optimization ethic that is 409 00:20:04,880 --> 00:20:08,760 Speaker 6: driving people's desire. Another piece that I'm sort of thinking 410 00:20:08,760 --> 00:20:12,199 Speaker 6: about is whether the looks maxing trends, you know, have 411 00:20:12,600 --> 00:20:15,760 Speaker 6: impacted Silicon Valley as well. So one of the founders 412 00:20:15,760 --> 00:20:17,640 Speaker 6: who I spoke to, who is using a weight loss 413 00:20:17,640 --> 00:20:20,840 Speaker 6: pep tide, mentioned that she watches IC launch videos and 414 00:20:20,880 --> 00:20:23,919 Speaker 6: she realizes none of the founders are overweight anymore. And 415 00:20:24,040 --> 00:20:26,080 Speaker 6: I'm gonna have to be on video if I'm a founder, 416 00:20:26,119 --> 00:20:27,959 Speaker 6: I'm going to have to go on podcasts, and I 417 00:20:28,000 --> 00:20:30,200 Speaker 6: want to make sure that I look my best. So 418 00:20:30,320 --> 00:20:33,280 Speaker 6: I do think that these sort of optimization trends are 419 00:20:33,359 --> 00:20:34,720 Speaker 6: impacting peptide use as well. 420 00:20:35,040 --> 00:20:38,080 Speaker 2: Yeah, this is something we've discussed on the show before. 421 00:20:38,200 --> 00:20:40,400 Speaker 2: But this idea that looks maxing is going to become 422 00:20:40,400 --> 00:20:44,280 Speaker 2: more important as information gets commoditized or the knowledge economy 423 00:20:44,320 --> 00:20:47,639 Speaker 2: gets commoditized via AI. Then your only edge is going 424 00:20:47,680 --> 00:20:50,240 Speaker 2: to be basically what you look like and how you 425 00:20:50,280 --> 00:20:53,360 Speaker 2: interact with people. By the way, I'm a big fan 426 00:20:53,440 --> 00:20:57,440 Speaker 2: of no lunch in the office, Joe knows. I refuse 427 00:20:57,560 --> 00:21:00,960 Speaker 2: to eat like the sad salads that cause twenty dollars 428 00:21:01,040 --> 00:21:03,280 Speaker 2: over here in New York. I find it's better just 429 00:21:03,280 --> 00:21:05,760 Speaker 2: to save my calories for like a really nice dinner. 430 00:21:06,160 --> 00:21:08,639 Speaker 2: But anyway, talk to us about how you've seen the 431 00:21:08,760 --> 00:21:12,919 Speaker 2: future of peptides kind of unrolling, because it does seem 432 00:21:13,000 --> 00:21:16,760 Speaker 2: to be. It's kind of a weird thing where these 433 00:21:16,800 --> 00:21:20,840 Speaker 2: are becoming more popular and presumably we're just at the 434 00:21:20,840 --> 00:21:24,760 Speaker 2: beginning stages of people hearing about this and more people 435 00:21:24,800 --> 00:21:30,760 Speaker 2: consuming them, but there's little to no sign of FDA 436 00:21:30,880 --> 00:21:34,000 Speaker 2: approval or these becoming sort of I don't want to 437 00:21:34,040 --> 00:21:37,119 Speaker 2: say legalized because they're in this gray market area, but 438 00:21:37,560 --> 00:21:39,600 Speaker 2: made official in some way. 439 00:21:40,240 --> 00:21:43,840 Speaker 6: Right, it's hard to say. Everyone I spoke to, whether 440 00:21:44,000 --> 00:21:47,360 Speaker 6: suppliers or doctors in California, definitely said that they saw 441 00:21:47,400 --> 00:21:50,560 Speaker 6: peptide use booming. This year. I've been seeing more news 442 00:21:50,640 --> 00:21:55,400 Speaker 6: in mainstream journal, mainstream newspaper outlets about personal peptide use. 443 00:21:55,840 --> 00:22:00,159 Speaker 6: I think that peptide use is going to explode as 444 00:22:00,200 --> 00:22:03,320 Speaker 6: people realize that I can be paying two hundred dollars 445 00:22:03,320 --> 00:22:05,679 Speaker 6: for the same semaglutide that I am currently getting for 446 00:22:05,760 --> 00:22:09,080 Speaker 6: twelve hundred. I find it very hard to imagine that 447 00:22:09,080 --> 00:22:11,880 Speaker 6: that is not going to explode. There are TikTok influencer 448 00:22:12,000 --> 00:22:15,359 Speaker 6: niches telling you how to mix the bacteriostatic water with 449 00:22:15,400 --> 00:22:17,600 Speaker 6: the powdered stuff in the vials, and how to inject 450 00:22:17,600 --> 00:22:19,800 Speaker 6: it if you've never done it before. As for the 451 00:22:19,840 --> 00:22:22,800 Speaker 6: policy environment, I think it's hard to predict. Last year, 452 00:22:23,080 --> 00:22:26,800 Speaker 6: RFK Junior, the Secretary of Health and Human Services, said 453 00:22:26,800 --> 00:22:29,560 Speaker 6: that he would end the Biden administration's war on peptides. 454 00:22:29,600 --> 00:22:32,480 Speaker 6: He sort of has embraced these take your health into 455 00:22:32,480 --> 00:22:36,480 Speaker 6: your own hands like experimental therapeutics. At the same time, 456 00:22:36,600 --> 00:22:39,640 Speaker 6: there hasn't actually been actions so far this year by 457 00:22:39,760 --> 00:22:43,280 Speaker 6: the Health and Human Services administration to bring peptides into 458 00:22:43,280 --> 00:22:46,679 Speaker 6: a more legal zone. So while RFK has signaled that 459 00:22:46,720 --> 00:22:48,840 Speaker 6: he will, there hasn't been policy action yet. I did 460 00:22:48,880 --> 00:22:51,800 Speaker 6: reach out to the AGHS and the FDA for comment, 461 00:22:52,119 --> 00:22:54,919 Speaker 6: and they said that they cannot predict future regulation, but 462 00:22:55,040 --> 00:22:59,280 Speaker 6: that they are actively revising the list of bolk peptides 463 00:22:59,400 --> 00:23:02,439 Speaker 6: that are a loud for compounding and compounding pharmacies, so 464 00:23:02,560 --> 00:23:05,560 Speaker 6: sort of classic we don't know, maybe looking at it language, 465 00:23:05,640 --> 00:23:08,240 Speaker 6: but folks in the peptide community are really hoping to 466 00:23:08,280 --> 00:23:11,360 Speaker 6: see a more at least less a fair regulatory stance 467 00:23:11,480 --> 00:23:14,400 Speaker 6: where they're not going to be shutting down these peptide suppliers. 468 00:23:14,680 --> 00:23:17,480 Speaker 2: Jasmine Son, that was absolutely amazing. You were truly the 469 00:23:17,480 --> 00:23:20,000 Speaker 2: perfect guest to talk about the intersection of peptides in 470 00:23:20,080 --> 00:23:21,240 Speaker 2: San Francisco culture. 471 00:23:21,280 --> 00:23:23,000 Speaker 3: So thank you so much for coming on all plots. 472 00:23:23,480 --> 00:23:25,600 Speaker 6: Thanks so much for having me better get ready for 473 00:23:25,640 --> 00:23:26,360 Speaker 6: my peptide rave. 474 00:23:26,960 --> 00:23:28,120 Speaker 4: That's right, fun. 475 00:23:43,800 --> 00:23:47,840 Speaker 2: So Joe, Jasmine did a great job of introducing us 476 00:23:47,920 --> 00:23:51,200 Speaker 2: to the peptide space about which we don't really know anything, 477 00:23:51,640 --> 00:23:54,119 Speaker 2: but I think we need to talk to someone who's 478 00:23:54,160 --> 00:23:55,520 Speaker 2: actually in the business. 479 00:23:55,680 --> 00:23:58,000 Speaker 4: Yeah, this is one of those stories where it's obviously 480 00:23:58,040 --> 00:24:03,119 Speaker 4: a cultural story, but it's also a supply chain regulation 481 00:24:03,800 --> 00:24:07,200 Speaker 4: marketing standpoint, like really coming from how do they get 482 00:24:07,240 --> 00:24:09,600 Speaker 4: into And for me, it's like, how do people have 483 00:24:09,680 --> 00:24:13,360 Speaker 4: any confidence like what they're literally injecting into their bodies? 484 00:24:13,640 --> 00:24:14,719 Speaker 4: Where's this coming from? 485 00:24:14,800 --> 00:24:17,359 Speaker 2: So I have the perfect second guest we're going to 486 00:24:17,400 --> 00:24:20,919 Speaker 2: be speaking with, Zach David. He is the managing partner 487 00:24:21,000 --> 00:24:25,040 Speaker 2: of per Sec Technologies, which runs Peptide Partners, which is 488 00:24:25,320 --> 00:24:26,880 Speaker 2: a supplier of peptide. 489 00:24:26,960 --> 00:24:28,800 Speaker 3: So, Zach, how did. 490 00:24:28,680 --> 00:24:31,720 Speaker 2: You get into the space, because you've had an interesting 491 00:24:31,840 --> 00:24:33,880 Speaker 2: career path, right. 492 00:24:34,520 --> 00:24:37,840 Speaker 5: I got into this space basically solving the problem for myself. 493 00:24:38,640 --> 00:24:42,080 Speaker 5: A few years ago. My health was very poor and 494 00:24:42,440 --> 00:24:45,320 Speaker 5: I started working with a specialist in the wellness and 495 00:24:45,400 --> 00:24:51,080 Speaker 5: longevity community and functional medicine, and I noticed the peptide 496 00:24:51,119 --> 00:24:55,160 Speaker 5: therapies that she was prescribing were highly effective but also 497 00:24:55,440 --> 00:24:58,680 Speaker 5: extremely expensive. So then I started up doing a little 498 00:24:58,680 --> 00:25:02,600 Speaker 5: supply chain sleuthing of my and found a much better 499 00:25:02,640 --> 00:25:06,119 Speaker 5: solution to that. And the question that she asked was 500 00:25:06,600 --> 00:25:08,240 Speaker 5: do you think it would be legal for me to 501 00:25:08,240 --> 00:25:10,879 Speaker 5: do that for my patients? And the answer is, of 502 00:25:10,920 --> 00:25:14,280 Speaker 5: course no, but that's set off a fourteen month investigation 503 00:25:14,359 --> 00:25:17,640 Speaker 5: on how to bring that into the legal market, which 504 00:25:17,680 --> 00:25:19,479 Speaker 5: is what we're eventually working on. 505 00:25:20,040 --> 00:25:22,520 Speaker 4: Why don't you tell us just sort of the basics 506 00:25:22,560 --> 00:25:25,240 Speaker 4: of what you do? What does the service your business provides? 507 00:25:26,560 --> 00:25:30,840 Speaker 5: So very similar to what I went through, a lot 508 00:25:30,840 --> 00:25:34,880 Speaker 5: of these peptide therapies are either met multi year or lifelong, 509 00:25:35,760 --> 00:25:42,800 Speaker 5: and they exist, and people are going to Chinese peptides 510 00:25:43,400 --> 00:25:49,520 Speaker 5: to find cheaper solutions, and so we started pushing for 511 00:25:49,800 --> 00:25:54,840 Speaker 5: independent testing for endotoxin screening for heavy metal testing, which 512 00:25:55,280 --> 00:25:57,600 Speaker 5: the incumbents in the industry were not doing at all 513 00:25:58,000 --> 00:26:00,479 Speaker 5: at the time, and now pretty much every body is. 514 00:26:01,720 --> 00:26:04,679 Speaker 2: So I have so many questions already, But how do 515 00:26:04,720 --> 00:26:09,879 Speaker 2: you actually go about finding a supplier for a particular peptide? 516 00:26:09,880 --> 00:26:12,159 Speaker 2: Because I imagine you know, you're dealing with people who 517 00:26:12,200 --> 00:26:15,199 Speaker 2: are all the way over in China. There's probably a 518 00:26:15,200 --> 00:26:18,199 Speaker 2: lot of different companies to choose from, and not that 519 00:26:18,320 --> 00:26:21,240 Speaker 2: much information out there about them. How do you even 520 00:26:21,280 --> 00:26:22,520 Speaker 2: begin to go about doing this. 521 00:26:22,960 --> 00:26:25,679 Speaker 5: There's a good mix of how to find them A 522 00:26:25,720 --> 00:26:31,439 Speaker 5: lot advertise on say TikTok, or they'll find you on WhatsApp. 523 00:26:32,040 --> 00:26:35,159 Speaker 5: They will hunt down your website and then introduce themselves 524 00:26:35,200 --> 00:26:38,359 Speaker 5: as suppliers, and so we go through a long vetting process. 525 00:26:38,800 --> 00:26:42,959 Speaker 5: By some estimates, there are ten major manufacturers, and then 526 00:26:42,960 --> 00:26:46,240 Speaker 5: they're a handful of that manufacture in house, and then 527 00:26:46,840 --> 00:26:49,399 Speaker 5: there's something called lyophilization, which is kind of like the 528 00:26:49,440 --> 00:26:52,760 Speaker 5: finishing step that puts it in the bodels. We basically 529 00:26:52,880 --> 00:26:56,320 Speaker 5: we're just constantly talking to new potential suppliers and we'll 530 00:26:56,359 --> 00:26:58,679 Speaker 5: give them a try. We'll send everything out for testing 531 00:26:59,320 --> 00:27:01,359 Speaker 5: and The labs that we use are based in the 532 00:27:01,440 --> 00:27:06,040 Speaker 5: US that follow USP standards and FDA guidelines, which is 533 00:27:06,040 --> 00:27:08,760 Speaker 5: a little bit different than some of the more popular 534 00:27:09,080 --> 00:27:10,440 Speaker 5: testing labs that are overseas. 535 00:27:11,280 --> 00:27:13,560 Speaker 4: Okay, talk us through the step by step. Okay, you 536 00:27:13,680 --> 00:27:18,080 Speaker 4: find a supplier based in China, you like them, whatever, 537 00:27:18,200 --> 00:27:20,960 Speaker 4: et cetera. Where does it arrive when it gets to 538 00:27:21,000 --> 00:27:22,880 Speaker 4: the US. Does it go to the lab first? Does 539 00:27:22,920 --> 00:27:24,760 Speaker 4: it go to you? If it goes to you, what 540 00:27:24,960 --> 00:27:29,520 Speaker 4: percentage of vials or what percentage of whatever is actually 541 00:27:29,720 --> 00:27:31,920 Speaker 4: checked such that you could say, okay, this is a 542 00:27:31,960 --> 00:27:32,399 Speaker 4: good batch. 543 00:27:33,640 --> 00:27:36,600 Speaker 5: Right, so we randomly sample from say we what are 544 00:27:36,600 --> 00:27:39,879 Speaker 5: a thousand viles, will randomly sample between three and five 545 00:27:40,760 --> 00:27:44,800 Speaker 5: and if the variance in the quality is very tight 546 00:27:45,200 --> 00:27:47,920 Speaker 5: and we consider that a good batch. We famously throw 547 00:27:47,960 --> 00:27:50,600 Speaker 5: out batches we don't consider up to our standards. And 548 00:27:50,640 --> 00:27:52,439 Speaker 5: sometimes we'll post pictures of us don't be in the 549 00:27:52,440 --> 00:27:55,359 Speaker 5: trash on Twitter, which gets us a little cachet. But 550 00:27:55,880 --> 00:27:58,480 Speaker 5: it's not fun to dump money in the garbage, but 551 00:27:59,160 --> 00:27:59,960 Speaker 5: sometimes you have to do it. 552 00:28:00,320 --> 00:28:02,520 Speaker 4: Can I just ask about the sequence of the chain 553 00:28:02,920 --> 00:28:05,919 Speaker 4: in particular, because it is a peptide, what is the 554 00:28:05,920 --> 00:28:09,119 Speaker 4: type of storage that it has to be involved in 555 00:28:09,200 --> 00:28:12,520 Speaker 4: from the container on the ship to the dock. Is 556 00:28:12,520 --> 00:28:15,200 Speaker 4: it a temperature type thing. How do you ensure that 557 00:28:15,240 --> 00:28:18,200 Speaker 4: sort of quality doesn't degrade during the shipping process. 558 00:28:18,840 --> 00:28:20,919 Speaker 5: Yeah, it's a great question. You know, if you were 559 00:28:21,040 --> 00:28:25,160 Speaker 5: shipping very large amounts, you would want a cold chain 560 00:28:25,560 --> 00:28:31,080 Speaker 5: supply the entire route. However, the lyophilization process keeps things 561 00:28:31,160 --> 00:28:35,240 Speaker 5: shelf stable for quite a long time, and recent studies 562 00:28:35,400 --> 00:28:38,800 Speaker 5: have shown that it doesn't degrade as fast as people 563 00:28:38,880 --> 00:28:42,600 Speaker 5: initially thought. So when we use commercial grade freezers, as 564 00:28:42,600 --> 00:28:44,479 Speaker 5: soon as we get it in and then we'll know, 565 00:28:44,560 --> 00:28:47,160 Speaker 5: we'll label the files and then we'll randomly sample. 566 00:28:47,560 --> 00:28:51,360 Speaker 2: Tell us more about the manufacturers in China because I'm 567 00:28:51,360 --> 00:28:54,080 Speaker 2: having a sort of hard time wrapping my head around 568 00:28:54,160 --> 00:28:56,680 Speaker 2: who they actually are. So I take it most of 569 00:28:56,680 --> 00:28:59,920 Speaker 2: them are not big pharma offshoots. They're sort of in 570 00:29:00,080 --> 00:29:04,880 Speaker 2: dependent manufacturers. But how are these companies actually I think 571 00:29:04,880 --> 00:29:06,160 Speaker 2: has coming into being. 572 00:29:07,600 --> 00:29:11,800 Speaker 5: Yeah, so there's an interesting mix of where the gray 573 00:29:11,840 --> 00:29:15,960 Speaker 5: market manufacturers and well, let's call it the lit market manufacturers. 574 00:29:16,480 --> 00:29:19,240 Speaker 5: There are a handful of ten to fifteen billion dollar 575 00:29:19,320 --> 00:29:24,040 Speaker 5: publicly traded companies in China that do contract manufacturing, but 576 00:29:24,160 --> 00:29:28,800 Speaker 5: they only sell to FDA supply like FDA registered companies 577 00:29:28,920 --> 00:29:34,160 Speaker 5: with supply chains, the major gray market labs, they only 578 00:29:34,200 --> 00:29:38,080 Speaker 5: sell to other companies within China who then finish it 579 00:29:38,120 --> 00:29:41,040 Speaker 5: with aliaphilization and then sell directly to the consumers. 580 00:29:42,160 --> 00:29:46,240 Speaker 2: And what's the actual material that makes up a peptide? 581 00:29:46,280 --> 00:29:48,560 Speaker 2: When we're talking about peptides, like, what are the building 582 00:29:48,640 --> 00:29:51,600 Speaker 2: blocks of a particular you know, I get a vile 583 00:29:51,800 --> 00:29:52,960 Speaker 2: in the mail? 584 00:29:53,200 --> 00:29:53,800 Speaker 6: What is it? 585 00:29:54,080 --> 00:29:54,600 Speaker 3: Exactly? 586 00:29:55,320 --> 00:30:00,600 Speaker 5: So? The FDA definition is that is a amino acid 587 00:30:00,680 --> 00:30:04,800 Speaker 5: chain of forty or less. That definition was added to 588 00:30:05,120 --> 00:30:07,960 Speaker 5: the Federal Register in twenty twenty. And it is no 589 00:30:08,080 --> 00:30:12,800 Speaker 5: surprise that things like semaglutide otherwise known as ozempic unjaro 590 00:30:12,920 --> 00:30:15,880 Speaker 5: otherwise known as zepetide, and the next generation that everyone 591 00:30:15,920 --> 00:30:19,080 Speaker 5: is currently using called regitrudtide, all happen to be exactly 592 00:30:19,080 --> 00:30:21,840 Speaker 5: thirty nine in light. So I think there was some 593 00:30:21,920 --> 00:30:27,040 Speaker 5: clever lobbying. But also things less than fifty tend to 594 00:30:27,040 --> 00:30:30,160 Speaker 5: be very stable, unlike larger proteins, which tend to fold 595 00:30:30,200 --> 00:30:33,920 Speaker 5: it on themselves, And the manufacturing process called solid face 596 00:30:34,000 --> 00:30:37,360 Speaker 5: peptide synthesis is almost a solved problem. 597 00:30:37,800 --> 00:30:40,120 Speaker 3: But how do we actually make amino acids? 598 00:30:40,680 --> 00:30:42,400 Speaker 5: That is a good question. I would have to follow 599 00:30:42,480 --> 00:30:45,080 Speaker 5: up with you on that. Some are naturally derived and 600 00:30:45,080 --> 00:30:49,240 Speaker 5: some are synthetic. The resurgence in peptides from its original 601 00:30:49,320 --> 00:30:53,720 Speaker 5: heyday is partially due to synthetic amino acids. 602 00:30:54,760 --> 00:30:57,760 Speaker 4: Just talk to us about law and regulation. What is 603 00:30:57,760 --> 00:30:59,680 Speaker 4: the stance of these things. I actually still don't totally 604 00:30:59,760 --> 00:31:03,120 Speaker 4: under stand. Are a legal to be sold? I don't 605 00:31:03,160 --> 00:31:05,760 Speaker 4: know what this term gray market means, et cetera. Just 606 00:31:05,880 --> 00:31:08,520 Speaker 4: walk to us about how the government, whether we're talking 607 00:31:08,600 --> 00:31:12,320 Speaker 4: criminal authorities or just FDA type authorities think about these 608 00:31:12,320 --> 00:31:12,920 Speaker 4: things right now. 609 00:31:14,000 --> 00:31:19,480 Speaker 5: So the guidance is very, very careful. There has to 610 00:31:19,520 --> 00:31:22,800 Speaker 5: be a lot of disclaimers about not for human use 611 00:31:23,080 --> 00:31:28,280 Speaker 5: on anything sold for research purposes. Doctors can prescribe them. 612 00:31:28,520 --> 00:31:32,400 Speaker 5: For example, there's one called Sir Moorlin where it was 613 00:31:32,440 --> 00:31:36,560 Speaker 5: abandoned by the manufacturer for economic reasons, not for safety reasons, 614 00:31:36,600 --> 00:31:39,480 Speaker 5: in around two thousand and eight, but you can get 615 00:31:39,480 --> 00:31:42,880 Speaker 5: it from compounding pharmacies in the United States, and so 616 00:31:43,000 --> 00:31:47,440 Speaker 5: doctors will was formally FDA approved. However, thanks from compounding 617 00:31:47,440 --> 00:31:51,240 Speaker 5: pharmacies do not undergo the same safety standards, But what 618 00:31:51,320 --> 00:31:54,840 Speaker 5: doctors will still prescribe stuff like that the FDA, I think, 619 00:31:56,280 --> 00:32:00,000 Speaker 5: put this when it's for research use only, then you're legit. 620 00:32:00,040 --> 00:32:02,560 Speaker 5: I'm really selling for research use. It does not fall 621 00:32:02,640 --> 00:32:03,120 Speaker 5: under there. 622 00:32:03,200 --> 00:32:06,680 Speaker 2: You just so a lot of people are conducting peptide 623 00:32:06,720 --> 00:32:08,800 Speaker 2: research in the comfort of their own homes. 624 00:32:09,200 --> 00:32:12,560 Speaker 5: Yes, as is. I'm sure you know most last listeners 625 00:32:12,560 --> 00:32:15,480 Speaker 5: are aware. The market for micropipets is growing eight percent 626 00:32:15,560 --> 00:32:18,000 Speaker 5: year over year projected through thirty thirty. So I do 627 00:32:18,080 --> 00:32:19,800 Speaker 5: believe that a lot of people have the home labs. 628 00:32:19,960 --> 00:32:26,120 Speaker 4: Yeah, we micro pipets. What do we yes, little pipets. 629 00:32:26,120 --> 00:32:28,680 Speaker 4: This is what is that? Oh, that's like a little 630 00:32:28,680 --> 00:32:31,600 Speaker 4: thing to extract some liquid. Is that what we're talking about? Yeah, 631 00:32:31,680 --> 00:32:34,560 Speaker 4: so this is our proxy for peptide consumption. Is the 632 00:32:34,560 --> 00:32:36,560 Speaker 4: booming market for micropipets. 633 00:32:36,640 --> 00:32:38,400 Speaker 5: It is the booming market for micropipets. 634 00:32:38,440 --> 00:32:38,920 Speaker 3: I'll take it. 635 00:32:39,200 --> 00:32:41,040 Speaker 5: So that's a little it's a little tongue in cheek, but. 636 00:32:41,160 --> 00:32:43,080 Speaker 4: No, no, no, but this is useful. It's like, okay, 637 00:32:43,160 --> 00:32:46,360 Speaker 4: like if we see this thing rising, then intuitively this 638 00:32:46,560 --> 00:32:49,360 Speaker 4: is what they're using for. So in your marketing, what 639 00:32:49,440 --> 00:32:51,880 Speaker 4: do you have to say such as that you don't 640 00:32:52,120 --> 00:32:55,400 Speaker 4: run a faul of people in DC or whatever. 641 00:32:56,200 --> 00:33:00,840 Speaker 5: We have strict terms and conditions for research use, labeled 642 00:33:00,880 --> 00:33:04,360 Speaker 5: on the boxes, labeled on the vials, labeled on their website. 643 00:33:04,640 --> 00:33:07,280 Speaker 5: We do not even use the term dosing. We only 644 00:33:07,280 --> 00:33:10,760 Speaker 5: talk about sample sizes and just We are very, very 645 00:33:10,920 --> 00:33:14,080 Speaker 5: very pro research. But there is a big movement of 646 00:33:14,160 --> 00:33:18,400 Speaker 5: people who self organize and telegram and discord communities who 647 00:33:18,440 --> 00:33:20,240 Speaker 5: are experimenting on themselves. 648 00:33:20,600 --> 00:33:24,040 Speaker 4: Longtime Internet friend of the podcast Bourb German bourb Bros. 649 00:33:24,200 --> 00:33:27,560 Speaker 4: Yes I saw she had a Chinese peptide rave in Francisco. 650 00:33:28,440 --> 00:33:32,760 Speaker 5: Yes, yes, yes, we sponsored it. It was nice. We 651 00:33:32,800 --> 00:33:35,280 Speaker 5: had a great time. She's a very very very good 652 00:33:35,320 --> 00:33:35,960 Speaker 5: friend of mine. 653 00:33:36,040 --> 00:33:38,120 Speaker 3: I'm guessing that's the same one Jasmine went to. 654 00:33:38,400 --> 00:33:46,640 Speaker 4: Probably unless Francisco. Could there be two Chinese problem, so. 655 00:33:46,760 --> 00:33:50,880 Speaker 2: Zach, how do you actually decide which peptides to stalk? 656 00:33:51,160 --> 00:33:54,120 Speaker 2: Is it whichever ones are getting the most buzz on TikTok? 657 00:33:54,600 --> 00:33:58,080 Speaker 2: Do the manufacturers approach you with new things that they're 658 00:33:58,120 --> 00:33:59,560 Speaker 2: making and then you test them out? 659 00:34:00,720 --> 00:34:03,240 Speaker 5: That's a yeah, that's a very good question because the 660 00:34:03,280 --> 00:34:07,240 Speaker 5: formulais change a lot. Although between the manufacturers and the 661 00:34:07,280 --> 00:34:12,320 Speaker 5: suppliers they do have very very similar formulais the ones 662 00:34:12,320 --> 00:34:17,279 Speaker 5: who deal with the controlled substances and anabolics we tend 663 00:34:17,280 --> 00:34:19,880 Speaker 5: to stay away from. But the ones that we stock, 664 00:34:20,520 --> 00:34:24,719 Speaker 5: we look for good safety profiles in humans. Unfortunately, for 665 00:34:24,840 --> 00:34:26,799 Speaker 5: almost all of these, there are not a lot of 666 00:34:26,800 --> 00:34:30,480 Speaker 5: good randomized control trials, but a lot of them have 667 00:34:30,640 --> 00:34:34,759 Speaker 5: good safety studies in humans. But so certain things like 668 00:34:34,800 --> 00:34:38,319 Speaker 5: there's a popular one called AOD nine to six oh 669 00:34:38,400 --> 00:34:41,640 Speaker 5: four which has not had a successful human trial ever, 670 00:34:42,360 --> 00:34:45,120 Speaker 5: and so we just decided not to stock that for 671 00:34:45,200 --> 00:34:46,200 Speaker 5: ethical reasons. 672 00:34:46,560 --> 00:34:48,799 Speaker 4: Okay, so we know that in theory, well we know 673 00:34:48,920 --> 00:34:51,400 Speaker 4: more than in theory that the west famous peptides can 674 00:34:51,480 --> 00:34:54,960 Speaker 4: cur g appetite and therefore facilitate weight loss. Tracy had 675 00:34:55,000 --> 00:34:59,320 Speaker 4: a little thing of a spray that ostensibly helped autists 676 00:34:59,520 --> 00:35:02,320 Speaker 4: make or eye contact, which is of course a valuable 677 00:35:02,360 --> 00:35:05,080 Speaker 4: skill if you want to live in human civilization. What 678 00:35:05,120 --> 00:35:07,200 Speaker 4: are some of the other what are some of the 679 00:35:07,280 --> 00:35:10,600 Speaker 4: other popular what are the other things that people are 680 00:35:10,640 --> 00:35:13,160 Speaker 4: consuming peptides? Are there any that might surprise us? 681 00:35:14,400 --> 00:35:17,560 Speaker 5: So there is a class called growth hormone releasing peptides 682 00:35:17,600 --> 00:35:20,759 Speaker 5: or growth me stimulating peptides. They have very short half 683 00:35:20,800 --> 00:35:25,919 Speaker 5: lives rather than like HGH replacement therapy, like human growth 684 00:35:26,000 --> 00:35:29,440 Speaker 5: on replacement therapy, which will eventually cause your body to 685 00:35:29,520 --> 00:35:33,279 Speaker 5: naturally stop producing its own This class works with your 686 00:35:33,280 --> 00:35:38,560 Speaker 5: pituitary to make like an impulse and release some growth 687 00:35:38,560 --> 00:35:40,160 Speaker 5: hormone rather than replace it. 688 00:35:40,760 --> 00:35:43,759 Speaker 4: So that would be clusters or bodybuilders or anyone who 689 00:35:43,840 --> 00:35:45,960 Speaker 4: just wants more strength or that we're talking about. 690 00:35:46,600 --> 00:35:50,799 Speaker 5: And yeah, and it's also been increasingly prescribed by physicians 691 00:35:50,880 --> 00:35:53,480 Speaker 5: for improved sleep as well. 692 00:35:53,480 --> 00:35:54,200 Speaker 4: I could use that. 693 00:35:56,680 --> 00:35:59,759 Speaker 2: Why don't we manufacture peptides in the US. How is 694 00:35:59,800 --> 00:36:03,120 Speaker 2: it but China seems to dominate this particular market. 695 00:36:03,840 --> 00:36:06,040 Speaker 5: That is a great question as well. I believe it's 696 00:36:06,040 --> 00:36:10,680 Speaker 5: the input, input materials, and the labor and expertise required 697 00:36:10,719 --> 00:36:14,200 Speaker 5: to engineer it. What happens is a lot of the 698 00:36:15,440 --> 00:36:19,920 Speaker 5: raw materials are produced in China and then over here 699 00:36:20,160 --> 00:36:24,560 Speaker 5: they're finished in facilities by doing the lyophilization and purification 700 00:36:24,880 --> 00:36:26,759 Speaker 5: steps by compounding pharmacies. 701 00:36:27,000 --> 00:36:29,719 Speaker 4: Okay, everyone who uses these, they have to inject them. 702 00:36:29,800 --> 00:36:30,080 Speaker 4: Is this? 703 00:36:30,280 --> 00:36:30,440 Speaker 5: Is it? 704 00:36:30,520 --> 00:36:31,480 Speaker 4: All needles and. 705 00:36:31,400 --> 00:36:35,040 Speaker 5: Files mostly At this time, however, we've seen an increasing 706 00:36:35,080 --> 00:36:38,440 Speaker 5: amount of oral formulations. The problem is because of these 707 00:36:38,440 --> 00:36:42,440 Speaker 5: are small molecules. The digestive system breaks them down very quickly, 708 00:36:43,040 --> 00:36:48,359 Speaker 5: so creating reliable oral formulations for peptide therapies as has 709 00:36:48,480 --> 00:36:50,719 Speaker 5: been historically very difficult. 710 00:37:05,800 --> 00:37:08,239 Speaker 2: How do you reduce costs in this space? Is it 711 00:37:08,400 --> 00:37:12,360 Speaker 2: buying in bulk from a particular supplier or I don't know, 712 00:37:12,440 --> 00:37:18,680 Speaker 2: finding cheaper manufacturers of vials and the lionization process, ionization. 713 00:37:18,120 --> 00:37:23,799 Speaker 5: Process, biophilization, biophilation, it's it's just a fancy word for 714 00:37:23,840 --> 00:37:24,399 Speaker 5: freeze drying. 715 00:37:24,480 --> 00:37:27,920 Speaker 2: Okay, all right, the freeze drying process. Then that's easier. 716 00:37:28,640 --> 00:37:32,000 Speaker 5: Yeah, so it is. It is buying in larger and 717 00:37:32,040 --> 00:37:37,600 Speaker 5: larger quantities. One of our manufacturing partners over there, they 718 00:37:37,640 --> 00:37:41,160 Speaker 5: created a novel method of being able to produce large 719 00:37:41,200 --> 00:37:45,040 Speaker 5: quantities of raw materials. And the next step in our 720 00:37:45,080 --> 00:37:49,400 Speaker 5: company's evolution is going to be buying a manufacturing facility 721 00:37:49,600 --> 00:37:52,640 Speaker 5: and starting to do that finishing step here and slowly 722 00:37:53,080 --> 00:37:57,080 Speaker 5: over time, bring this above board and fully FDA compliant. 723 00:37:57,480 --> 00:38:00,319 Speaker 4: Am I stupid for not using peptides? I work good 724 00:38:00,320 --> 00:38:04,799 Speaker 4: in a very competitive industry. I have a very demanding schedule. 725 00:38:04,960 --> 00:38:08,560 Speaker 4: I have two children. I'm forty five, and so I'm 726 00:38:08,600 --> 00:38:10,520 Speaker 4: at the second half of the curve and my body 727 00:38:10,600 --> 00:38:12,759 Speaker 4: is getting a little deteriorating and getting a little bit 728 00:38:12,760 --> 00:38:16,080 Speaker 4: closer to death each day. Like am I stupid for 729 00:38:16,360 --> 00:38:19,080 Speaker 4: like not tasting the fruits of advanced science? 730 00:38:20,120 --> 00:38:22,280 Speaker 5: That is a question between you and your physician. 731 00:38:23,120 --> 00:38:27,240 Speaker 4: Okay, that is a very smart answer. Do you feel 732 00:38:27,680 --> 00:38:30,520 Speaker 4: that it is an important element of your ability to 733 00:38:30,640 --> 00:38:34,600 Speaker 4: thrive and compete your research into peptides? 734 00:38:35,760 --> 00:38:38,840 Speaker 5: I do. I like them a lot. I've noticed a 735 00:38:38,880 --> 00:38:43,080 Speaker 5: lot of good changes, especially my health my energy over 736 00:38:43,120 --> 00:38:45,960 Speaker 5: the years. But I also do work closely with a 737 00:38:46,000 --> 00:38:47,600 Speaker 5: physician and under the care of one. 738 00:38:47,880 --> 00:38:50,239 Speaker 4: Can I ask you a little bit about marketing. How 739 00:38:50,280 --> 00:38:51,800 Speaker 4: do people discover your company? 740 00:38:52,760 --> 00:38:56,400 Speaker 5: I think it will serve So let's see. Word of 741 00:38:56,440 --> 00:39:01,319 Speaker 5: mouth has been great, of several influencers written about like 742 00:39:01,600 --> 00:39:05,120 Speaker 5: the cost effectiveness of our product. And then there's a 743 00:39:05,200 --> 00:39:10,400 Speaker 5: website called Fenric which has started to offer this wonderful 744 00:39:10,440 --> 00:39:14,799 Speaker 5: service where people can send in files from anyone that 745 00:39:14,840 --> 00:39:18,360 Speaker 5: they buy off any of these research use only sites. 746 00:39:18,480 --> 00:39:21,040 Speaker 5: I think they've cover over one hundred and forty companies now, 747 00:39:21,760 --> 00:39:26,040 Speaker 5: and we've started to take number one slots on their 748 00:39:26,760 --> 00:39:29,480 Speaker 5: site just left and right. So I think we're doing something. 749 00:39:29,520 --> 00:39:31,279 Speaker 5: We're doing something a little bit better than everyone else. 750 00:39:31,480 --> 00:39:35,120 Speaker 2: So people crowdsourcing a lot of the research and reviews. 751 00:39:35,360 --> 00:39:38,200 Speaker 2: And also, I guess you hold peptide raves, right, that's 752 00:39:38,200 --> 00:39:39,120 Speaker 2: a marketing. 753 00:39:38,760 --> 00:39:42,920 Speaker 5: Thing that was once. It might happen again. You know, 754 00:39:43,120 --> 00:39:44,960 Speaker 5: I'm not much of a I'm not much of a 755 00:39:45,040 --> 00:39:48,080 Speaker 5: d answer, but I did. I did feel some questions. 756 00:39:48,520 --> 00:39:50,919 Speaker 4: Something that sort of works a little bit like human 757 00:39:50,960 --> 00:39:54,880 Speaker 4: growth hormone, I get very appealing weight loss again, concentrations. 758 00:39:54,880 --> 00:39:59,879 Speaker 4: Are there any surprising peptides? What's the most unexpected thing 759 00:40:00,040 --> 00:40:03,479 Speaker 4: that a peptide might in research suggest could benefit someone. 760 00:40:04,080 --> 00:40:05,479 Speaker 5: I don't know if I should say this out loud? 761 00:40:05,800 --> 00:40:06,120 Speaker 5: Let me do? 762 00:40:06,080 --> 00:40:07,359 Speaker 4: You definitely should say that loud. 763 00:40:08,080 --> 00:40:12,399 Speaker 5: Yeah, okay, Well, there is one peptide that goes under 764 00:40:12,440 --> 00:40:15,920 Speaker 5: the name pt one one, it's brand name. It's actually 765 00:40:15,960 --> 00:40:18,960 Speaker 5: an FT approved one. It's called Vilisi, and it is 766 00:40:19,040 --> 00:40:20,879 Speaker 5: meant for low sex drive. 767 00:40:22,280 --> 00:40:25,240 Speaker 4: Very completely legitimate. Nothing wrong with saying that out loud 768 00:40:25,400 --> 00:40:26,160 Speaker 4: for men and women. 769 00:40:27,360 --> 00:40:30,120 Speaker 5: It's meant for it's meant for women, but according to 770 00:40:30,960 --> 00:40:34,279 Speaker 5: people that I who have told me, it works for 771 00:40:34,360 --> 00:40:34,839 Speaker 5: men as well. 772 00:40:35,480 --> 00:40:40,120 Speaker 2: Many people are saying, what's the what's the customs process? 773 00:40:40,239 --> 00:40:40,680 Speaker 3: Actually? 774 00:40:40,920 --> 00:40:43,480 Speaker 2: Like for this because I imagine, I mean, customs is 775 00:40:43,520 --> 00:40:45,880 Speaker 2: a pain at the best of times, and I imagine 776 00:40:45,960 --> 00:40:49,080 Speaker 2: for something like this, it's potentially even more complicated. And 777 00:40:49,120 --> 00:40:51,839 Speaker 2: then also, have you been impacted by tariffs at all? 778 00:40:53,239 --> 00:40:56,640 Speaker 5: Yeah, it was really fun to see the first time 779 00:40:57,160 --> 00:41:01,120 Speaker 5: a UPS driver ask for cash on delivery since like 780 00:41:01,200 --> 00:41:06,280 Speaker 5: nineteen ninety eight, you know, rubber rubber cash on delivery. 781 00:41:07,360 --> 00:41:10,879 Speaker 5: That was when they when tariffs first came back, and 782 00:41:10,920 --> 00:41:14,160 Speaker 5: no one really knew. No one had the infrastructure to 783 00:41:14,280 --> 00:41:18,000 Speaker 5: charge in advance. Now they'll now, they'll let you know, Hey, 784 00:41:18,360 --> 00:41:21,480 Speaker 5: you're going to owe thirty dollars here, sixty dollars here. 785 00:41:22,120 --> 00:41:25,720 Speaker 2: It's like an online payment portal too, right, It's yeah, 786 00:41:25,800 --> 00:41:26,640 Speaker 2: it's none, but. 787 00:41:26,640 --> 00:41:29,479 Speaker 5: It originally there wasn't. Originally there wasn't a driver showed 788 00:41:29,560 --> 00:41:33,000 Speaker 5: up and wanted to check. Yeah, interesting piece, It was crazy. 789 00:41:33,120 --> 00:41:36,680 Speaker 4: I'm ready about this PC one. So unlike viagra, which 790 00:41:36,719 --> 00:41:40,880 Speaker 4: famously opens up blood flow pathways, this one, it's a 791 00:41:40,920 --> 00:41:44,920 Speaker 4: method of action, is actually to increase the underlying sexual 792 00:41:44,960 --> 00:41:49,880 Speaker 4: excitement itself, which is sort of a different way. It's interesting. 793 00:41:49,960 --> 00:41:51,440 Speaker 5: I have heard I have heard that it works. 794 00:41:51,800 --> 00:41:52,680 Speaker 4: You've heard that it works. 795 00:41:53,280 --> 00:41:55,560 Speaker 5: Yep. I don't have any experience with it, but I've 796 00:41:55,600 --> 00:41:56,400 Speaker 5: heard that it works. 797 00:41:57,040 --> 00:41:59,799 Speaker 2: Wait, so what does the customs documentation actually look like 798 00:42:00,120 --> 00:42:01,960 Speaker 2: when the stuff arrives at a port? 799 00:42:02,040 --> 00:42:03,520 Speaker 3: What forms are you filling out? 800 00:42:03,640 --> 00:42:06,480 Speaker 5: They're fun, They're you know, half a Mandarin, so it's 801 00:42:06,480 --> 00:42:07,160 Speaker 5: a little bit different. 802 00:42:08,000 --> 00:42:12,280 Speaker 4: Ascanis We're fun. Language doesn't matter these days. 803 00:42:12,480 --> 00:42:14,839 Speaker 2: How long do you think it's going to take, if 804 00:42:14,880 --> 00:42:18,000 Speaker 2: it happens at all, for these sorts of peptides to 805 00:42:18,120 --> 00:42:21,400 Speaker 2: become as you put it, above board in the US. 806 00:42:21,880 --> 00:42:25,520 Speaker 5: So there's an interesting history there. So the most popular 807 00:42:25,520 --> 00:42:29,239 Speaker 5: ones basically in September twenty twenty three, we call the 808 00:42:29,239 --> 00:42:33,240 Speaker 5: pepside arm again, about seventeen twenty of the most popular 809 00:42:33,280 --> 00:42:36,920 Speaker 5: ones that were prescribed by doctors in the wellness and 810 00:42:36,960 --> 00:42:40,600 Speaker 5: longevity community were put on this what's called the five 811 00:42:40,719 --> 00:42:45,719 Speaker 5: H three a banned list, and they banned the prescribing 812 00:42:46,440 --> 00:42:51,640 Speaker 5: or the compounding of certain peptides. And according to my physician, 813 00:42:52,000 --> 00:42:56,560 Speaker 5: it was not for particularly good scientific reasons, but the 814 00:42:56,640 --> 00:43:00,280 Speaker 5: explanation that they give is that it can trigger immunevers 815 00:43:00,920 --> 00:43:02,560 Speaker 5: the adversary immune responses. 816 00:43:04,200 --> 00:43:06,480 Speaker 4: Last question for me, has there been any change in 817 00:43:06,600 --> 00:43:09,759 Speaker 4: DC since the changing of the administration in terms of 818 00:43:09,800 --> 00:43:11,280 Speaker 4: either at the FDA or otherwise. 819 00:43:12,760 --> 00:43:16,920 Speaker 5: So I go through all of the enforcement letters that 820 00:43:17,040 --> 00:43:18,719 Speaker 5: the fs and you can go on the website and 821 00:43:18,760 --> 00:43:21,839 Speaker 5: you can see every enforcement letter and every warning letter 822 00:43:21,920 --> 00:43:24,760 Speaker 5: that they send to every single website. And I believe 823 00:43:24,800 --> 00:43:28,520 Speaker 5: the last one ever sent was December twenty twenty four, 824 00:43:29,160 --> 00:43:32,240 Speaker 5: so there has not been a lot of enforcement. 825 00:43:32,600 --> 00:43:35,200 Speaker 2: Yeah, that's a pretty big hint. All right, Zach, We're 826 00:43:35,200 --> 00:43:36,680 Speaker 2: going to leave it there, But thank you so much 827 00:43:36,719 --> 00:43:40,040 Speaker 2: for coming on all thoughts. That was super interesting, such 828 00:43:40,040 --> 00:43:41,800 Speaker 2: a huge fancy thank you. 829 00:43:42,040 --> 00:43:43,560 Speaker 4: We're going to use it. And this is a real 830 00:43:43,640 --> 00:43:44,400 Speaker 4: thank you so much. 831 00:43:44,320 --> 00:43:57,640 Speaker 3: That so Joe. 832 00:43:57,680 --> 00:44:01,920 Speaker 2: That was really interesting one episode. So obviously it intersects 833 00:44:02,000 --> 00:44:05,720 Speaker 2: with a bunch of athots themes, primarily competition with China 834 00:44:06,040 --> 00:44:10,080 Speaker 2: in the biotech space and also supply chain issues and 835 00:44:10,320 --> 00:44:11,440 Speaker 2: medical regulation. 836 00:44:11,680 --> 00:44:14,279 Speaker 4: Are we going to see the White House adopt a 837 00:44:14,560 --> 00:44:18,120 Speaker 4: industrial policy to wean us off of our dependence on 838 00:44:18,320 --> 00:44:21,560 Speaker 4: China for experimental peptides? Well, I want to talk about that. 839 00:44:21,640 --> 00:44:24,719 Speaker 2: What I was about to say is, actually we've talked 840 00:44:24,719 --> 00:44:28,160 Speaker 2: about this before, but you could envision a world where 841 00:44:28,480 --> 00:44:32,920 Speaker 2: knowledge becomes very commodified because of AI, and so everyone's 842 00:44:32,960 --> 00:44:36,719 Speaker 2: competitive edge is basically what you look like, how you 843 00:44:36,760 --> 00:44:41,080 Speaker 2: present yourself and interact with others. So maybe in that economy, 844 00:44:41,239 --> 00:44:42,600 Speaker 2: peptides have a lot of value. 845 00:44:42,840 --> 00:44:45,200 Speaker 4: Absolutely, I could totally say it. I mean, I think, 846 00:44:45,320 --> 00:44:47,920 Speaker 4: I mean the way I think about that question is 847 00:44:48,360 --> 00:44:50,560 Speaker 4: we don't even need to talk about AI in the 848 00:44:50,640 --> 00:44:53,560 Speaker 4: sense that we are already on this path. Right. People 849 00:44:53,600 --> 00:44:57,680 Speaker 4: have been looks maxing prior to the invention of chatbots. 850 00:44:57,719 --> 00:45:01,320 Speaker 4: People have felt ever since the maybe since the iPhone 851 00:45:01,400 --> 00:45:02,760 Speaker 4: or maybe since Instagram. 852 00:45:02,360 --> 00:45:06,239 Speaker 3: Etcetera, have always mattered. But I think we're at acceleration point. 853 00:45:06,320 --> 00:45:08,680 Speaker 4: Yeah, you know what I'm saying is like this already 854 00:45:08,760 --> 00:45:12,439 Speaker 4: feels like it's accelerating some of these Trent. Absolutely, looks 855 00:45:12,440 --> 00:45:15,640 Speaker 4: have always mattered, people have always been anxious about their weight, 856 00:45:15,800 --> 00:45:18,920 Speaker 4: et cetera. But it does feel like this pressure is 857 00:45:19,040 --> 00:45:21,399 Speaker 4: just building where everyone is thinking about these things. Everyone 858 00:45:21,440 --> 00:45:24,360 Speaker 4: feels very competitive all of these things, and everyone is 859 00:45:24,480 --> 00:45:26,320 Speaker 4: open about how competitive. 860 00:45:26,120 --> 00:45:28,040 Speaker 3: Very open. It's kind of surprising. 861 00:45:28,160 --> 00:45:30,399 Speaker 2: Yeah, there was a time when people didn't talk about 862 00:45:30,480 --> 00:45:34,000 Speaker 2: things like their plastic surgery, but it seems very or 863 00:45:34,160 --> 00:45:36,359 Speaker 2: more transparent than it needs to be. The other thing 864 00:45:36,400 --> 00:45:39,799 Speaker 2: I was thinking about, just in terms of regulation. I mean, 865 00:45:39,840 --> 00:45:43,680 Speaker 2: it's notable that it's a gray market right as we described, 866 00:45:43,880 --> 00:45:48,680 Speaker 2: and ostensibly everyone is doing peptide research in their basements, 867 00:45:48,719 --> 00:45:51,120 Speaker 2: and that's kind of a joke, right, But on the 868 00:45:51,160 --> 00:45:54,759 Speaker 2: other hand, it's not really a joke because what we're 869 00:45:54,840 --> 00:45:59,560 Speaker 2: doing is kind of outsourcing human trials. Yeah, I guess 870 00:45:59,600 --> 00:46:02,919 Speaker 2: to like citizens who are opting in, they're the ones 871 00:46:03,000 --> 00:46:05,719 Speaker 2: opting in to test these new treatments. 872 00:46:06,000 --> 00:46:08,839 Speaker 4: You know, it's interesting we did that episode with day 873 00:46:08,920 --> 00:46:11,359 Speaker 4: Wallack and he talked about how we could have a 874 00:46:11,480 --> 00:46:15,640 Speaker 4: model of sort of market for pharmaceuticals and therapies in 875 00:46:15,680 --> 00:46:18,120 Speaker 4: which the only thing required to sell something is the 876 00:46:18,160 --> 00:46:21,760 Speaker 4: safety trial. Right now, for any therapy, we do safety 877 00:46:21,800 --> 00:46:24,840 Speaker 4: and then efficacy, but it is very you could argue 878 00:46:24,880 --> 00:46:27,000 Speaker 4: that really the only thing that should be required is 879 00:46:27,239 --> 00:46:29,680 Speaker 4: a safety trial and then it's up to the consumer 880 00:46:29,800 --> 00:46:32,239 Speaker 4: or whatever. You know. I think you could make that 881 00:46:32,360 --> 00:46:34,719 Speaker 4: argument that then it's up to the doctor and the 882 00:46:34,760 --> 00:46:38,760 Speaker 4: consumer together to decide is this worthwhile given the price 883 00:46:38,800 --> 00:46:41,040 Speaker 4: of what we know about, et cetera. But what it 884 00:46:41,080 --> 00:46:44,319 Speaker 4: feels like to me is we're sort of entering this 885 00:46:44,480 --> 00:46:48,600 Speaker 4: era in which regardless of what the formal law states 886 00:46:48,719 --> 00:46:52,280 Speaker 4: or what regulation state. There is a cultural move towards 887 00:46:52,400 --> 00:46:56,000 Speaker 4: letting people experiment as they want with things that by 888 00:46:56,040 --> 00:46:59,040 Speaker 4: and large, it doesn't sound like there's much evidence of 889 00:46:59,080 --> 00:47:02,560 Speaker 4: particularly harmful dangerous with a lot of this stuff. 890 00:47:02,680 --> 00:47:05,120 Speaker 2: Maybe no one has died from peptides that I. 891 00:47:05,080 --> 00:47:06,880 Speaker 4: Know, as far as I know, I haven't seen that, 892 00:47:07,040 --> 00:47:08,960 Speaker 4: et cetera. And so it feels like we're sort of, 893 00:47:09,239 --> 00:47:12,480 Speaker 4: you know, this is part of the hacker culture. It's like, Okay, 894 00:47:12,640 --> 00:47:15,080 Speaker 4: there's probably not much danger, I suppose, but what it 895 00:47:15,120 --> 00:47:17,319 Speaker 4: does for you, that's on you to figure out. 896 00:47:17,440 --> 00:47:20,839 Speaker 2: All Right, Thank you everyone who is experimenting with peptides. 897 00:47:20,920 --> 00:47:22,960 Speaker 2: You're doing it for the greater good. I'm sure. 898 00:47:23,239 --> 00:47:23,960 Speaker 3: Shall we leave it there. 899 00:47:24,040 --> 00:47:24,759 Speaker 4: Let's leave it there. 900 00:47:24,920 --> 00:47:27,360 Speaker 2: This has been another episode of the Odd Lots podcast. 901 00:47:27,480 --> 00:47:30,480 Speaker 2: I'm Tracy Alloway. You can follow me at Tracy Alloway. 902 00:47:30,640 --> 00:47:33,560 Speaker 4: And I'm Joe Wisenthal. You can follow me at The Stalwart, 903 00:47:33,719 --> 00:47:36,759 Speaker 4: follow our guesst Jasmine Son She's at Jasmine New Sun, 904 00:47:37,160 --> 00:47:40,160 Speaker 4: and Zach David. He's at Zach David. 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