WEBVTT - The Inflammation Theory of Disease 0:00:01.480 --> 0:00:07.760 Welcome to Stuff You Should Know, a production of iHeartRadio. 0:00:11.200 --> 0:00:14.319 Hey, and welcome to the podcast. I'm Josh, there's Chuck. 0:00:14.560 --> 0:00:17.799 Jerry's here. We're all swollen in red and that makes 0:00:17.840 --> 0:00:20.119 this a brand new episode of Stuff you Should Know. 0:00:21.920 --> 0:00:24.439 You know, I haven't told you this yet, but this 0:00:24.480 --> 0:00:29.560 is a very special episode, my friend. Oh yeah, because hopefully, 0:00:29.640 --> 0:00:32.800 if all goes well, this is the very last episode 0:00:33.000 --> 0:00:35.760 I will be recording in my basement. 0:00:36.479 --> 0:00:38.440 Oh. This is the end of an era. 0:00:38.400 --> 0:00:43.159 Chuck, the end of an era that started obviously in 0:00:43.159 --> 0:00:48.920 March twenty twenty and it's been three just a little 0:00:48.960 --> 0:00:51.960 over three years in the dark basement. 0:00:53.040 --> 0:00:54.120 Dank. Don't forget Dank. 0:00:54.360 --> 0:00:57.400 It is dank, and I am very excited. You know this, 0:00:57.520 --> 0:01:00.600 But I'm going to be moving into my my brand 0:01:00.680 --> 0:01:04.800 new home studio. That is a very cool space that 0:01:05.080 --> 0:01:08.120 is built under my staircase. 0:01:08.880 --> 0:01:12.119 I have two words to describe it, high falutin. 0:01:13.160 --> 0:01:16.120 Well it was. I was inspired by David Diggs. I 0:01:16.120 --> 0:01:20.279 saw his He has a record listening room heavy digs 0:01:20.480 --> 0:01:24.200 of Hamilton Fame and other things. But he has a 0:01:24.240 --> 0:01:28.240 record LP vinyl listening room glassed in and built in 0:01:28.319 --> 0:01:33.040 under his staircase and I was like, oh wow, I 0:01:33.160 --> 0:01:33.880 see the future. 0:01:34.319 --> 0:01:37.280 Yeah, that's pretty good. Plus also nobody knows what to 0:01:37.319 --> 0:01:38.960 do with the under the staircase thing. 0:01:39.000 --> 0:01:41.920 That's a great use of it wasted space. So now 0:01:41.920 --> 0:01:45.479 there's a recording studio under there. Jerry is coming over 0:01:45.560 --> 0:01:50.640 tomorrow with our colleague Josh Than Yeah tech tech wizard, 0:01:51.920 --> 0:01:53.320 and they're going to get it all set up and 0:01:53.320 --> 0:01:57.000 we're going to do some testing. And I'm just super 0:01:57.000 --> 0:02:01.360 excited to be moving into a bright, well lit, beautiful space. 0:02:01.840 --> 0:02:05.200 And I will put pictures of this studio on my Instagram. 0:02:06.360 --> 0:02:09.400 Chuck the podcaster, be sure to like be squinting from 0:02:09.400 --> 0:02:12.359 the new light that you're exposed to you in your 0:02:12.400 --> 0:02:13.040 new setup. 0:02:13.400 --> 0:02:15.440 And also very quickly. I don't know if you've checked 0:02:15.480 --> 0:02:18.680 your mail or where your Governor's award was being shipped, 0:02:19.280 --> 0:02:20.880 But mine just got here today, buddy. 0:02:21.120 --> 0:02:24.440 Yeah, mine says it's on the way according to fed X. 0:02:25.040 --> 0:02:27.160 Yeah, so we got the Governor's award. They shipped them 0:02:27.160 --> 0:02:30.760 to us and I just unboxed it and it's really 0:02:30.880 --> 0:02:33.440 cool and heavy and feels like a real award. And 0:02:33.480 --> 0:02:35.880 that is going to be displayed in the new studio. 0:02:36.040 --> 0:02:39.480 Oh yeah, totally. Well, congratulations Chuck on your award. 0:02:39.880 --> 0:02:41.919 I'm very very well you got the award too. 0:02:42.520 --> 0:02:45.600 Sure I can still congratulate you, and congratulations on what 0:02:45.639 --> 0:02:48.240 you thought. I was congratulating you on your new setup. 0:02:48.520 --> 0:02:50.880 Some may say that you are more than fifty percent 0:02:50.919 --> 0:02:51.960 responsible for that award. 0:02:53.200 --> 0:02:59.239 No, no, exactly fifty percent down the middle, where's Jerry Finnet? Oh, man, 0:02:59.520 --> 0:03:02.600 geez the b it's ten percent. I hate fractions because. 0:03:02.320 --> 0:03:04.040 You know we always go one hundred and ten percent. 0:03:04.360 --> 0:03:06.520 Yeah, I guess. I guess we're each thirty three and 0:03:06.560 --> 0:03:09.080 a third responsible for it. And then who knows who's 0:03:09.120 --> 0:03:11.080 making up that extra hundredth of a percent? 0:03:12.960 --> 0:03:14.919 All right, So anyway, announcements are out of the way. 0:03:15.280 --> 0:03:16.320 Let's talk inflammation. 0:03:17.160 --> 0:03:21.200 Okay, that's that's the most straight ahead segue I've ever 0:03:21.320 --> 0:03:23.920 heard us too, But thank you for that, because we 0:03:23.960 --> 0:03:26.600 are talking about inflammation, and I think everybody's basically heard 0:03:26.639 --> 0:03:29.440 of inflammation. But the inflammation that you've heard of is 0:03:29.480 --> 0:03:31.440 like what happens when you sprain your ankle or cut 0:03:31.480 --> 0:03:34.480 your finger or something like that. Yeah, what we've discovered 0:03:34.560 --> 0:03:38.080 is that there's another kind of inflammation. It's the same inflammation, 0:03:38.200 --> 0:03:42.520 but there's just different parameters to it that take it 0:03:42.560 --> 0:03:45.440 from being like a really important part of a healthy 0:03:45.480 --> 0:03:50.160 immune system and turn it into a thing that will 0:03:50.240 --> 0:03:55.360 kill you basically over time. And it's actually they're finding 0:03:55.400 --> 0:04:00.520 that inflammation is a common factor in so many different diseases, 0:04:00.560 --> 0:04:09.280 from heart disease to depression to diabetes, all sorts of stuff, 0:04:09.320 --> 0:04:12.520 I mean, just the gamut types of cancer. That there's 0:04:12.880 --> 0:04:16.679 they basically come up with a new unifying theory of disease, 0:04:16.720 --> 0:04:20.000 the inflammation theory of disease that if you if you 0:04:20.080 --> 0:04:24.760 look close enough, in almost any especially noncommunicable diseases, but 0:04:24.839 --> 0:04:29.040 those two there, there's inflammation and that that's really what's 0:04:29.040 --> 0:04:29.960 screwing you up. 0:04:30.640 --> 0:04:36.160 Yeah, that's it. Goodbye, goodbye. Yeah. It's called chronic inflammation. 0:04:36.360 --> 0:04:39.640 And the word inflammation and big thanks to Dave Ruse, 0:04:39.920 --> 0:04:42.239 yeah for this. This is very thorough. 0:04:42.279 --> 0:04:44.400 I thought of biblical time machine fame. 0:04:44.680 --> 0:04:49.599 That's right. The word inflammation is Latin and root of 0:04:49.600 --> 0:04:53.880 course in flammatio, and it means to ignite or to 0:04:53.960 --> 0:04:57.640 set fire in Latin. And that is really kind of 0:04:57.960 --> 0:05:00.320 straight down the middle as far as what inflammation and 0:05:00.360 --> 0:05:06.279 feels like, and in fact, the descriptors of the four characteristics, 0:05:06.520 --> 0:05:09.600 and we'll touch on the fifth of inflammation goes all 0:05:09.640 --> 0:05:13.320 the way back to our old buddy Galen, the Roman 0:05:13.480 --> 0:05:15.320 physician from the first century AD. 0:05:15.680 --> 0:05:18.440 He pops up almost as much as our friend Pliny. 0:05:19.160 --> 0:05:21.240 Did they know each other, Were they contemporaries? 0:05:22.640 --> 0:05:26.240 There's plenty I don't. Well, Pliny was in the first 0:05:26.960 --> 0:05:30.400 half of the first century, I think, and yeah, I think. Yeah, 0:05:30.480 --> 0:05:31.800 they were probably good friends. 0:05:32.000 --> 0:05:33.400 They were drinking buddies. 0:05:33.480 --> 0:05:35.320 They probably played cornhole together. 0:05:37.320 --> 0:05:42.080 That has many implications. I know, they might beat beer drinkers, 0:05:42.960 --> 0:05:44.680 they might have their Saturday spree. 0:05:45.400 --> 0:05:45.840 What else. 0:05:46.160 --> 0:05:50.640 They might be handy with a saw so they build 0:05:50.680 --> 0:05:54.120 their own. Sure, they may like football games and tailgating. 0:05:54.520 --> 0:05:58.560 Yeah, there was a lot wrapped up in corn hole playing. Yeah. 0:05:58.640 --> 0:06:00.599 So Galen is the one who who kind of nailed 0:06:00.600 --> 0:06:02.800 it out of the gate way back then and said 0:06:02.839 --> 0:06:06.479 that if you are inflamed, you will have redness, you 0:06:06.560 --> 0:06:09.960 have swelling, Sure, you will have heat check, you will 0:06:10.000 --> 0:06:14.760 have pain out, and then you have My friend Josh 0:06:14.839 --> 0:06:19.000 emailed me today and just saying no, Josh Clark and 0:06:19.080 --> 0:06:22.960 said that there's also a fifth one, buddy, and you 0:06:23.040 --> 0:06:25.040 have loss of function. But I'm going to amend your 0:06:25.200 --> 0:06:29.120 email to impaired function, okay for reduced function. 0:06:29.480 --> 0:06:31.960 Yeah, which is like if you have if you have 0:06:32.040 --> 0:06:35.760 that sprained ankle and it's inflamed, you're not walking around 0:06:35.760 --> 0:06:38.359 on that ankle, you're basically not using it for the 0:06:38.400 --> 0:06:41.480 time being, or you're barely, very gingerly using it. So yeah, 0:06:41.640 --> 0:06:44.680 impaired function makes actually a lot more sense. Way to go. 0:06:45.320 --> 0:06:48.200 Sure, and this is all good stuff like this acute inflammation. 0:06:48.600 --> 0:06:50.680 And we've talked about it before plenty of times, and 0:06:51.880 --> 0:06:57.440 oh boy, lots of podcasts pollin autoimmune disorders, like actually 0:06:57.480 --> 0:06:59.440 autoimmune you probably touched on it, but that's as we'll 0:06:59.440 --> 0:07:03.280 see a different thing. But acute inflammation is a good thing. 0:07:03.320 --> 0:07:06.640 This is when your body mounts a defense and you know, 0:07:06.680 --> 0:07:09.560 if you sprain that ankle, or if you cut your hand, 0:07:10.200 --> 0:07:14.400 or if you have stripped throat or something, then your 0:07:14.440 --> 0:07:17.280 body basically says, all right, you know, we need to 0:07:17.320 --> 0:07:21.040 go to that wound with a lot of stuff with 0:07:21.560 --> 0:07:26.240 T cells, with B cells. I think they're basically all 0:07:26.320 --> 0:07:29.520 lumped into this group called inflammatory mediators. 0:07:29.040 --> 0:07:33.640 Right, yeah, well they are the ones that release inflammatory mediators, 0:07:33.680 --> 0:07:35.640 I believe, So like these are the cells that go 0:07:35.680 --> 0:07:38.720 and do stuff like eat other cells or eat pathogens 0:07:38.720 --> 0:07:41.160 and spit them out or carry them into the lymph nodes. 0:07:41.480 --> 0:07:44.280 But the inflammatory mediators are what they release, and those 0:07:44.320 --> 0:07:48.520 are like hormones like histamines and brady Kinan's right. And 0:07:48.560 --> 0:07:52.000 then those mediators are the ones that are actually having 0:07:52.080 --> 0:07:54.680 like effects on your body. They're the ones that like 0:07:55.240 --> 0:07:58.960 dilate your blood vessels to bring more blood to the area, 0:07:59.000 --> 0:08:04.320 which makes itmer and red or they also they also 0:08:04.440 --> 0:08:07.880 irritate your nerve endings, so that's where the pain comes from. 0:08:08.480 --> 0:08:10.600 That's the mediators that are doing all the stuff that 0:08:10.640 --> 0:08:15.040 your body is experiencing as like acute inflammation. But they're 0:08:15.040 --> 0:08:18.360 brought to that site, I believe, by white blood cells, right. 0:08:18.560 --> 0:08:20.480 And the reason and we're saying it kind of like 0:08:20.520 --> 0:08:23.440 everyone knows, because I think everyone kind of knows this, sure, 0:08:23.520 --> 0:08:27.520 But the reason why your capillaries are expanding around the 0:08:27.800 --> 0:08:30.560 ankle sprain or around the cut or whatever is is 0:08:30.600 --> 0:08:33.400 basically just saying like, hey, we need to get more 0:08:33.440 --> 0:08:35.960 blood there, so take the express train. We're gonna puff 0:08:36.040 --> 0:08:40.040 up and no stopping along the way, and let's just 0:08:40.160 --> 0:08:41.920 get as much good stuff in there as fast as 0:08:41.960 --> 0:08:42.280 we can. 0:08:42.600 --> 0:08:46.360 Yeah, which also accounts for fluid collection, which is another 0:08:46.480 --> 0:08:51.880 kind of sub feature of inflammation, which which I've never 0:08:51.920 --> 0:08:55.920 really thought of before, but it makes sense. And then consequently, 0:08:55.960 --> 0:08:57.960 your lymph note do you know when those get kind 0:08:57.960 --> 0:09:01.679 of swollen when you're sick, that's because all that inflame 0:09:01.880 --> 0:09:05.600 stuff that those macrofages are eating and carrying out take 0:09:05.600 --> 0:09:07.920 them to the lymph nodes, and your lift notes get 0:09:08.000 --> 0:09:12.080 swollen from over work and eventually go back down once 0:09:12.120 --> 0:09:14.400 they drain out all of that crud. And the same 0:09:14.440 --> 0:09:16.719 thing to you also chuck for your running nose. 0:09:17.760 --> 0:09:19.360 My running knows that I have right now. 0:09:19.600 --> 0:09:24.880 Yes, it's because your mucous membranes are inflamed, and by 0:09:24.920 --> 0:09:29.480 bringing more fluid to the site, it's easier to more 0:09:29.559 --> 0:09:31.400 quickly flush out all that crud. 0:09:32.000 --> 0:09:34.439 Yeah. Do you remember when I went to the hospital 0:09:34.480 --> 0:09:38.240 in New York when we were had our initial book 0:09:39.440 --> 0:09:41.240 push that didn't become the book. 0:09:41.080 --> 0:09:43.400 Yeah, with our buddy Steven. I was thinking about it. 0:09:43.440 --> 0:09:44.440 Not a week ago. 0:09:44.480 --> 0:09:48.920 Really, Yeah, So remember I went to the hospital. What 0:09:48.960 --> 0:09:50.679 hospital was it, I can't remember, you know, one of 0:09:50.720 --> 0:09:54.719 the New York City hospitals, right like Manhattan. Yeah, it 0:09:54.760 --> 0:09:56.400 was what did I end up having I can't even 0:09:56.400 --> 0:09:57.000 remember now. 0:09:57.280 --> 0:09:59.480 I thought it was like a like some sort of 0:09:59.559 --> 0:10:01.600 terrible astritis or something like that. 0:10:01.800 --> 0:10:05.040 I don't remember. That probably blocked it out of my mind. 0:10:05.600 --> 0:10:08.000 But long story short, after they had sort of healed 0:10:08.040 --> 0:10:09.320 me from this and they were like, all right, you 0:10:09.320 --> 0:10:13.240 can go. And I woke up from my drug induced 0:10:13.240 --> 0:10:16.320 stupor in my hospital bed. I felt behind my ear 0:10:17.000 --> 0:10:20.319 and I had a like a ping pong ball behind 0:10:20.320 --> 0:10:20.920 my ear. 0:10:20.840 --> 0:10:22.840 And I was like so disconcerting, what is this? 0:10:23.520 --> 0:10:25.600 And I would go to the nurse and I was like, hey, man, 0:10:25.679 --> 0:10:29.800 what is hair Bab Sammy Davis Junior hair Bab? I 0:10:29.840 --> 0:10:33.640 have a golf ball behind my ear? And he he was. 0:10:33.760 --> 0:10:35.040 He kind of gave me a look like what is 0:10:35.080 --> 0:10:38.320 it with you? Like are you a hypochondriac? And I 0:10:38.360 --> 0:10:41.079 was like, no, dude, look at it. It's huge. And 0:10:41.120 --> 0:10:42.760 I think he could just sort of dismissed it and 0:10:42.800 --> 0:10:44.199 was like, yeah, it's probably just some sort of a 0:10:44.240 --> 0:10:49.080 swollen node from whatever this was, and you don't worry 0:10:49.080 --> 0:10:49.480 about it. 0:10:49.679 --> 0:10:51.640 Yeah. No, I remember you coming to lunch and being 0:10:51.679 --> 0:10:55.360 like I was just roundly mistreated by like this nurse. 0:10:55.360 --> 0:10:57.640 Who was he was great actually, but he was just 0:10:57.679 --> 0:11:00.600 basically like, don't sweat it, please leave. We need Yeah, 0:11:00.640 --> 0:11:04.600 for sure, But anyway, that was my body again, just 0:11:04.679 --> 0:11:07.119 puffing up when something happened exactly. 0:11:07.320 --> 0:11:10.280 So that's part of your acute immune response. You get 0:11:10.320 --> 0:11:13.600 dilated blood vessels, you get more blood there, it's easier 0:11:13.600 --> 0:11:15.439 for the white blood cells to get in and out 0:11:15.480 --> 0:11:18.080 of those vessels. You got irritated, nurse, you have pain, 0:11:18.120 --> 0:11:21.400 you got fluid collecting all the stuff that happens when 0:11:21.440 --> 0:11:24.840 you cut yourself or you sprain an ankle. I don't 0:11:24.880 --> 0:11:26.200 know why I keep going to that, but it's a 0:11:26.240 --> 0:11:30.480 good one. It's a good one, and that's normal. That's 0:11:30.760 --> 0:11:35.439 your acute immune inflammatory response. Is that's a normal part 0:11:35.559 --> 0:11:38.439 of getting rid of a pathogen or treating an injury 0:11:38.679 --> 0:11:40.880 or a good thing like that. Yeah, your body's under 0:11:40.960 --> 0:11:44.040 some sort of stress and your immune system goes swarm 0:11:44.160 --> 0:11:48.120 swarm and inflames the area to help repair it more. 0:11:48.320 --> 0:11:51.440 It also one of the reasons why it gets warm 0:11:51.800 --> 0:11:53.640 and one of the reasons also why you might feel 0:11:53.679 --> 0:11:56.679 tired if you have a particularly bad infection, is because 0:11:56.720 --> 0:11:59.800 your body is diverting a lot of your energy and 0:12:00.080 --> 0:12:04.280 tabolism too, fighting off whatever that is or treating that site, 0:12:04.360 --> 0:12:07.439 whatever it is, so you don't have like the energy 0:12:07.520 --> 0:12:12.040 to do cartwheels or anything because it's being used otherwise, again, 0:12:12.520 --> 0:12:16.440 totally normal. The problem is is if this keeps going on, 0:12:17.280 --> 0:12:19.959 even if it drops down to a lower level, if 0:12:20.000 --> 0:12:24.320 it continues long after it should have stopped, now you've 0:12:24.320 --> 0:12:27.640 got problems. And this is the basis of that unified 0:12:27.679 --> 0:12:31.760 theory of disease, that chronic inflammation, systemic chronic inflammation that 0:12:31.760 --> 0:12:32.520 you're talking about. 0:12:32.920 --> 0:12:40.200 Yeah, sci or ci ski Ski that's what they call them. 0:12:40.200 --> 0:12:42.880 The BIZ Sure one example of this, and we're going 0:12:42.920 --> 0:12:45.640 to go over a lot of different examples, but one 0:12:45.720 --> 0:12:48.520 example is, you know, sometimes you have infections that don't 0:12:48.559 --> 0:12:51.720 go away and your body mounts that immune response, but 0:12:51.760 --> 0:12:55.200 it's not just like, okay, we cured your or we 0:12:55.240 --> 0:12:57.120 got rid of your bronchitis for an now or whatever. 0:12:58.000 --> 0:13:02.160 There are long term infections that are very persistent. Hepatitis 0:13:02.200 --> 0:13:06.800 is one, HIV is another, they think long COVID maybe another. 0:13:07.400 --> 0:13:11.280 Where your body has this immune response and it mounts it, 0:13:11.920 --> 0:13:14.600 but it doesn't go away completely, so it doesn't wipe 0:13:14.640 --> 0:13:18.240 out all those pathogens and so it just stays around. 0:13:18.280 --> 0:13:22.439 So your body has sort of a low level inflammatory 0:13:22.559 --> 0:13:26.400 response always happening in the case of these long term infections, 0:13:26.920 --> 0:13:30.080 and your body is just sort of constantly trying to 0:13:30.120 --> 0:13:30.520 fight it. 0:13:31.120 --> 0:13:34.559 Right, So that's one that's a you can at least 0:13:34.559 --> 0:13:38.120 trace it back to a cause in that instance. Right. Yes, 0:13:38.480 --> 0:13:42.199 there's another thing that triggers chronic systemic chronic inflammation. That's 0:13:42.240 --> 0:13:46.000 oxidative stress, which we talked about in our Free Radicals episode. 0:13:46.040 --> 0:13:48.960 Is the free radical theory of aging. Wrong, Remember it 0:13:49.000 --> 0:13:50.560 came out but in the last couple of years. 0:13:50.640 --> 0:13:51.360 Right, it's a good one. 0:13:51.600 --> 0:13:54.600 Yeah, it was. But we talked about oxidative stress, which 0:13:54.640 --> 0:14:00.480 is where free radicals these radically free little molecules that 0:14:01.120 --> 0:14:05.960 borrow electrons from whatever is around it. They're super reactive molecules, 0:14:06.360 --> 0:14:09.680 and by borrowing an electron, that cell or that other 0:14:09.800 --> 0:14:15.120 molecule needed that electron. So it's now in disrepair, it's 0:14:15.120 --> 0:14:18.880 not functioning correctly, maybe it's dying. It's a problem. And 0:14:19.120 --> 0:14:24.880 free radicals another term from is reactive oxidative species, reactive 0:14:24.880 --> 0:14:29.200 oxygen species. I think they're normal, like we produce those 0:14:29.280 --> 0:14:34.119 just from everything from like breathing to the immune system. Right, 0:14:34.200 --> 0:14:38.080 but they're supposed to be in balance. We have antioxidants 0:14:38.160 --> 0:14:40.840 naturally produced, and we can also absorb them from food 0:14:41.040 --> 0:14:43.680 that neutralize them. They go up to them, they say, 0:14:43.720 --> 0:14:46.640 take my electron, and they're now neutralized. They're not going 0:14:46.720 --> 0:14:48.880 to take it from a nearby cell or something like that. 0:14:49.120 --> 0:14:52.600 If that gets out of balance, you've got oxidative stress 0:14:53.040 --> 0:14:56.400 where you have more cells than you should being damaged 0:14:56.400 --> 0:14:58.880 by these free radicals because you have more free radicals 0:14:58.880 --> 0:15:02.000 than you should. And then the immune response says, we 0:15:02.120 --> 0:15:05.000 got a problem over there. Let's get this area inflamed. 0:15:05.520 --> 0:15:09.760 That's right, and that's oxidative stress. That's another reason that 0:15:09.800 --> 0:15:14.160 you could point to for systemic chronic inflammation. The problem 0:15:14.240 --> 0:15:17.840 is chuck. There's also there's also types of chronic inflammation 0:15:18.160 --> 0:15:22.920 that have no reason whatsoever, like the body's just not 0:15:23.280 --> 0:15:25.960 doing what it's supposed to do. It's basically confused in 0:15:26.080 --> 0:15:27.480 your suffering as a result. 0:15:28.000 --> 0:15:32.080 Yeah, and we talked about, you know, autoimmune disorders, and 0:15:33.480 --> 0:15:35.680 we haven't done one on rum it's what arthritis yet, 0:15:35.680 --> 0:15:36.800 but I think that's probably coming. 0:15:37.080 --> 0:15:37.360 Sure. 0:15:37.720 --> 0:15:41.280 Lupus is another example. I mean, we talked about allergies 0:15:41.320 --> 0:15:46.880 and how that's that's an overblown immune response to yourself. Yeah, 0:15:47.360 --> 0:15:49.680 so in these cases, you're you know, your white blood 0:15:49.680 --> 0:15:53.640 cells are being dispatched to you know, whatever you would 0:15:53.680 --> 0:15:57.400 consider like the point of origin. I guess, and the 0:15:57.440 --> 0:15:59.480 body makes a mistake and said, all right, well I 0:15:59.520 --> 0:16:04.000 gotta I gotta start inflaming myself, and it inflames healthy 0:16:04.040 --> 0:16:07.880 tissues and healthy organs, and a lot of damage can 0:16:07.920 --> 0:16:10.200 be caused in a big, big way. 0:16:10.680 --> 0:16:15.080 Yeah, because again, like this immune response, this inflammation shouldn't 0:16:15.120 --> 0:16:19.480 be happening anyway. It's targeting healthy stuff. It's turned on itself. 0:16:19.520 --> 0:16:22.920 Your body's turned on itself. That's problematic in and of itself. 0:16:23.200 --> 0:16:26.640 But because your body's still producing all the same things 0:16:26.680 --> 0:16:29.440 that your immune system is now mistaking as like foreign 0:16:29.440 --> 0:16:33.960 invaders or pathogens, it's constantly going to be mounting this 0:16:34.120 --> 0:16:38.600 inflammatory response, and so you're going to have systemic chronic 0:16:38.640 --> 0:16:40.120 inflammation from that as well. 0:16:40.760 --> 0:16:42.640 All right, shall we take a break, I think so 0:16:43.240 --> 0:16:45.280 all right, we're gonna take a break. I'm gonna move 0:16:45.280 --> 0:16:49.520 into the new studio. Oh wait, best tomorrow, sorry very eager. 0:16:49.720 --> 0:17:19.800 Oh wait, we'll be right back. All right, So we're 0:17:19.840 --> 0:17:24.280 back talking inflammation. This is Inflammatalk with Josh and Chuck 0:17:25.240 --> 0:17:30.400 and not every chronic disease or everything that can kill 0:17:30.440 --> 0:17:34.199 you is linked to chronic inflammation. But yeah, you go 0:17:34.320 --> 0:17:39.080 over the list, it's like the most the major killers 0:17:39.160 --> 0:17:43.480 of humans you can usually link to chronic inflammation, high 0:17:43.520 --> 0:17:51.000 blood pressure, heart disease, type two diabetes, chronic kidney disease, IBS. Inflammatory, 0:17:51.040 --> 0:17:54.840 the word is even in there, inflammatory, bowel disease, asthma. 0:17:55.640 --> 0:17:59.520 Other you know, we'll talk about lung cancer later and 0:17:59.640 --> 0:18:02.040 colon cancer later, but those are a couple of kinds 0:18:02.040 --> 0:18:07.840 of cancer. We mentioned rheumatoid arthritis. But there are some 0:18:07.880 --> 0:18:10.040 surprising things in here that we're going to go over 0:18:10.040 --> 0:18:13.320 here in a few minutes. What is depression, Another is 0:18:13.400 --> 0:18:17.920 Parkinson's and dementia yep. And then the final one on 0:18:18.119 --> 0:18:21.400 Dave's list, it's a very thorough list, is non alcoholic 0:18:21.440 --> 0:18:24.959 fatty liver disease. And this is basically, you know, all 0:18:25.000 --> 0:18:27.960 the doctors have gotten together now, they all got together 0:18:28.000 --> 0:18:31.800 in one room and they said, we've got a situation 0:18:31.880 --> 0:18:35.320 on our hands where we can officially all agree, like 0:18:36.080 --> 0:18:41.480 the inflammation theory of disease is sort of coalescing, and 0:18:41.560 --> 0:18:42.879 we we're pretty sure about all this. 0:18:43.280 --> 0:18:46.240 Right, there's an outstanding chicken or the egg question though, 0:18:46.280 --> 0:18:49.720 that they've yet to answer, and that is the inflammation. 0:18:49.920 --> 0:18:53.600 Is chronic inflammation the cause of these chronic diseases or 0:18:53.640 --> 0:18:56.159 is it a symptom of these chronic diseases And they 0:18:56.200 --> 0:18:58.800 don't know yet. I'm going to put a substantial amount 0:18:58.840 --> 0:19:02.040 of my money on it's the cause. Yeah, I don't 0:19:02.040 --> 0:19:03.760 think it's the symptom. I think the way that we've 0:19:03.800 --> 0:19:08.600 been approaching disease is the idea that inflammation would be 0:19:08.640 --> 0:19:12.560 a symptom of it, like you have some problem, some 0:19:12.720 --> 0:19:16.159 external problem that's coming into your body that's causing wreaking 0:19:16.160 --> 0:19:19.320 all this havoc. It's actually not right. So let's say 0:19:19.320 --> 0:19:21.520 you're talking about sugar. You eat a bunch of sugar. 0:19:21.760 --> 0:19:24.840 The sugar itself is not causing problems in your body. 0:19:25.000 --> 0:19:29.320 The sugar is triggering inflammation and chronic inflammation in some cases, 0:19:29.520 --> 0:19:32.600 and that's the problem. That doesn't mean sugar is blameless 0:19:32.800 --> 0:19:35.480 because your body's still responding to it and it's it's 0:19:35.640 --> 0:19:37.560 just going to do that every time you eat sugar. 0:19:38.000 --> 0:19:41.439 But it's not the sugar itself. So I think the 0:19:41.560 --> 0:19:43.840 inflammation is the cause of the disease. 0:19:44.760 --> 0:19:48.159 Yeah, I think I'm with you. Let's go over this 0:19:48.200 --> 0:19:52.040 first really interesting example of something that we kind of 0:19:52.040 --> 0:19:54.280 thought we had figured out and now we know so 0:19:54.359 --> 0:19:58.800 much more about, and that is Alzheimer's disease. I'll give 0:19:58.800 --> 0:20:02.360 you a we've do we do one specifically on Alzheimer's. 0:20:03.640 --> 0:20:06.080 I think it was dementia. I don't. I think it 0:20:06.200 --> 0:20:07.920 was I don't. I don't remember. 0:20:08.200 --> 0:20:09.720 Okay, well, I know we've talked about it. But the 0:20:09.760 --> 0:20:14.040 quickest refresher Alzheimer's is a type of dementia, and it's 0:20:14.040 --> 0:20:16.200 neuronal death. Is what's going on. We have a couple 0:20:16.280 --> 0:20:20.119 of things in the brain that function well until they don't. 0:20:20.920 --> 0:20:24.640 One is called amyloid beta proteins. These are little clusters 0:20:24.680 --> 0:20:27.680 around your neurons in a healthy brain, and they aid 0:20:27.840 --> 0:20:31.359 in neural growth and repair, doing a really good job. 0:20:31.720 --> 0:20:35.119 But when they become misfolded, then all of a sudden, 0:20:35.240 --> 0:20:39.639 it becomes We've talked about amyloid plaques, and that's what 0:20:39.680 --> 0:20:43.960 they are. These plaques form and they're basically misfolded versions 0:20:44.080 --> 0:20:48.400 of ordinarily good amyloid beta proteins, and these are outside 0:20:48.440 --> 0:20:52.760 the neurons. There's also something inside the neurons called taulproteins, 0:20:53.320 --> 0:20:55.840 and these are also great. They do great work, big 0:20:55.880 --> 0:20:59.840 fan they aid in neuron structure and kind of keep 0:20:59.880 --> 0:21:02.880 them nice and strong from the inside. But these can 0:21:02.920 --> 0:21:07.760 also become misfolded. But they're misfolded on the inside and 0:21:07.840 --> 0:21:10.800 all of a sudden it becomes what's called a neurofibrillary 0:21:10.880 --> 0:21:12.200 tangle or a towel tangle. 0:21:12.280 --> 0:21:13.080 That sounds bad. 0:21:13.480 --> 0:21:16.520 It does sound bad, And we've known for a while now, like, hey, 0:21:16.720 --> 0:21:19.679 if you have amyloid plaques and these towel tangles in 0:21:19.720 --> 0:21:24.919 your brain, then that is what is causing this Alzheimer's disease, 0:21:25.280 --> 0:21:28.280 the type of dementia. But now they've zeroed in and said, 0:21:28.359 --> 0:21:32.720 you know what, we think it's really this neuroinflammation that's 0:21:32.760 --> 0:21:34.840 going on in the brain that's the real root cause. 0:21:35.119 --> 0:21:39.280 Yeah, that's actually a good example of this inflammatory theory 0:21:39.320 --> 0:21:44.160 of disease. Creating a chicken or egg question about those 0:21:44.240 --> 0:21:47.280 tau tangles and amyloid plaques, Like, we used to think 0:21:47.280 --> 0:21:49.280 that that was the problem, but now is that just 0:21:49.320 --> 0:21:53.119 a symptom of it. We're not sure. But there's a 0:21:53.160 --> 0:21:58.959 couple theories on how neuroinflammation would cause Alzheimer's, specifically and 0:21:59.400 --> 0:22:02.040 one of them is that it's based around microglia cells. 0:22:02.320 --> 0:22:05.560 We talked about macrophasias that go around and eat like pathogens. 0:22:06.359 --> 0:22:09.080 This is the brain's version of that, a really specialized 0:22:09.160 --> 0:22:11.680 version that goes around and like cleans up the brain, 0:22:11.720 --> 0:22:16.080 eating neurons that are problematic or have stopped functioning or 0:22:16.080 --> 0:22:18.639 it's just their time to go. And they do a 0:22:18.640 --> 0:22:22.399 really good job normally, but over time, especially when we 0:22:22.440 --> 0:22:27.200 get old, those microglia can also turn on healthy neurons 0:22:27.640 --> 0:22:31.439 and which would make Alzheimer's and all of the loss 0:22:31.440 --> 0:22:37.800 of function and cognitive ability and behavioral changes in autoimmune condition, right, Yeah, 0:22:38.040 --> 0:22:40.879 which is not exactly what you think of when you 0:22:40.920 --> 0:22:42.560 think of Alzheimer's. 0:22:43.040 --> 0:22:46.280 Yeah, But here's the thing is, they've done some interesting studies. 0:22:47.240 --> 0:22:51.560 They've done autopsies on patients that have, like you know, 0:22:51.560 --> 0:22:53.760 we talked about the build up of these amyloid plaques 0:22:53.760 --> 0:22:57.199 and everyone's like, that's what causes Alzheimer's. They've done autopsies 0:22:57.200 --> 0:23:01.439 on these brains that had really far gone amyloid plaque 0:23:01.440 --> 0:23:05.639 build ups but really not much neuroinflammation going on, and 0:23:05.760 --> 0:23:08.600 the patients had no symptoms of dementia in these cases. 0:23:08.920 --> 0:23:10.720 But I mean, isn't it possible it's just because they 0:23:10.760 --> 0:23:13.200 were dead, they probably didn't have symptoms of anything. 0:23:14.960 --> 0:23:20.760 Very funny, Go ahead, all right, Sorry I was holding 0:23:20.760 --> 0:23:24.800 for applause. But then they looked at patients with not 0:23:25.040 --> 0:23:27.920