1
00:00:01,480 --> 00:00:07,760
Speaker 1: Welcome to Stuff You Should Know, a production of iHeartRadio.

2
00:00:11,200 --> 00:00:14,319
Speaker 2: Hey, and welcome to the podcast. I'm Josh, there's Chuck.

3
00:00:14,560 --> 00:00:17,799
Speaker 2: Jerry's here. We're all swollen in red and that makes

4
00:00:17,840 --> 00:00:20,119
Speaker 2: this a brand new episode of Stuff you Should Know.

5
00:00:21,920 --> 00:00:24,439
Speaker 1: You know, I haven't told you this yet, but this

6
00:00:24,480 --> 00:00:29,560
Speaker 1: is a very special episode, my friend. Oh yeah, because hopefully,

7
00:00:29,640 --> 00:00:32,800
Speaker 1: if all goes well, this is the very last episode

8
00:00:33,000 --> 00:00:35,760
Speaker 1: I will be recording in my basement.

9
00:00:36,479 --> 00:00:38,440
Speaker 2: Oh. This is the end of an era.

10
00:00:38,400 --> 00:00:43,159
Speaker 1: Chuck, the end of an era that started obviously in

11
00:00:43,159 --> 00:00:48,920
Speaker 1: March twenty twenty and it's been three just a little

12
00:00:48,960 --> 00:00:51,960
Speaker 1: over three years in the dark basement.

13
00:00:53,040 --> 00:00:54,120
Speaker 2: Dank. Don't forget Dank.

14
00:00:54,360 --> 00:00:57,400
Speaker 1: It is dank, and I am very excited. You know this,

15
00:00:57,520 --> 00:01:00,600
Speaker 1: But I'm going to be moving into my my brand

16
00:01:00,680 --> 00:01:04,800
Speaker 1: new home studio. That is a very cool space that

17
00:01:05,080 --> 00:01:08,120
Speaker 1: is built under my staircase.

18
00:01:08,880 --> 00:01:12,119
Speaker 2: I have two words to describe it, high falutin.

19
00:01:13,160 --> 00:01:16,120
Speaker 1: Well it was. I was inspired by David Diggs. I

20
00:01:16,120 --> 00:01:20,279
Speaker 1: saw his He has a record listening room heavy digs

21
00:01:20,480 --> 00:01:24,200
Speaker 1: of Hamilton Fame and other things. But he has a

22
00:01:24,240 --> 00:01:28,240
Speaker 1: record LP vinyl listening room glassed in and built in

23
00:01:28,319 --> 00:01:33,040
Speaker 1: under his staircase and I was like, oh wow, I

24
00:01:33,160 --> 00:01:33,880
Speaker 1: see the future.

25
00:01:34,319 --> 00:01:37,280
Speaker 2: Yeah, that's pretty good. Plus also nobody knows what to

26
00:01:37,319 --> 00:01:38,960
Speaker 2: do with the under the staircase thing.

27
00:01:39,000 --> 00:01:41,920
Speaker 1: That's a great use of it wasted space. So now

28
00:01:41,920 --> 00:01:45,479
Speaker 1: there's a recording studio under there. Jerry is coming over

29
00:01:45,560 --> 00:01:50,640
Speaker 1: tomorrow with our colleague Josh Than Yeah tech tech wizard,

30
00:01:51,920 --> 00:01:53,320
Speaker 1: and they're going to get it all set up and

31
00:01:53,320 --> 00:01:57,000
Speaker 1: we're going to do some testing. And I'm just super

32
00:01:57,000 --> 00:02:01,360
Speaker 1: excited to be moving into a bright, well lit, beautiful space.

33
00:02:01,840 --> 00:02:05,200
Speaker 1: And I will put pictures of this studio on my Instagram.

34
00:02:06,360 --> 00:02:09,400
Speaker 2: Chuck the podcaster, be sure to like be squinting from

35
00:02:09,400 --> 00:02:12,359
Speaker 2: the new light that you're exposed to you in your

36
00:02:12,400 --> 00:02:13,040
Speaker 2: new setup.

37
00:02:13,400 --> 00:02:15,440
Speaker 1: And also very quickly. I don't know if you've checked

38
00:02:15,480 --> 00:02:18,680
Speaker 1: your mail or where your Governor's award was being shipped,

39
00:02:19,280 --> 00:02:20,880
Speaker 1: But mine just got here today, buddy.

40
00:02:21,120 --> 00:02:24,440
Speaker 2: Yeah, mine says it's on the way according to fed X.

41
00:02:25,040 --> 00:02:27,160
Speaker 1: Yeah, so we got the Governor's award. They shipped them

42
00:02:27,160 --> 00:02:30,760
Speaker 1: to us and I just unboxed it and it's really

43
00:02:30,880 --> 00:02:33,440
Speaker 1: cool and heavy and feels like a real award. And

44
00:02:33,480 --> 00:02:35,880
Speaker 1: that is going to be displayed in the new studio.

45
00:02:36,040 --> 00:02:39,480
Speaker 2: Oh yeah, totally. Well, congratulations Chuck on your award.

46
00:02:39,880 --> 00:02:41,919
Speaker 1: I'm very very well you got the award too.

47
00:02:42,520 --> 00:02:45,600
Speaker 2: Sure I can still congratulate you, and congratulations on what

48
00:02:45,639 --> 00:02:48,240
Speaker 2: you thought. I was congratulating you on your new setup.

49
00:02:48,520 --> 00:02:50,880
Speaker 1: Some may say that you are more than fifty percent

50
00:02:50,919 --> 00:02:51,960
Speaker 1: responsible for that award.

51
00:02:53,200 --> 00:02:59,239
Speaker 2: No, no, exactly fifty percent down the middle, where's Jerry Finnet? Oh, man,

52
00:02:59,520 --> 00:03:02,600
Speaker 2: geez the b it's ten percent. I hate fractions because.

53
00:03:02,320 --> 00:03:04,040
Speaker 1: You know we always go one hundred and ten percent.

54
00:03:04,360 --> 00:03:06,520
Speaker 2: Yeah, I guess. I guess we're each thirty three and

55
00:03:06,560 --> 00:03:09,080
Speaker 2: a third responsible for it. And then who knows who's

56
00:03:09,120 --> 00:03:11,080
Speaker 2: making up that extra hundredth of a percent?

57
00:03:12,960 --> 00:03:14,919
Speaker 1: All right, So anyway, announcements are out of the way.

58
00:03:15,280 --> 00:03:16,320
Speaker 1: Let's talk inflammation.

59
00:03:17,160 --> 00:03:21,200
Speaker 2: Okay, that's that's the most straight ahead segue I've ever

60
00:03:21,320 --> 00:03:23,920
Speaker 2: heard us too, But thank you for that, because we

61
00:03:23,960 --> 00:03:26,600
Speaker 2: are talking about inflammation, and I think everybody's basically heard

62
00:03:26,639 --> 00:03:29,440
Speaker 2: of inflammation. But the inflammation that you've heard of is

63
00:03:29,480 --> 00:03:31,440
Speaker 2: like what happens when you sprain your ankle or cut

64
00:03:31,480 --> 00:03:34,480
Speaker 2: your finger or something like that. Yeah, what we've discovered

65
00:03:34,560 --> 00:03:38,080
Speaker 2: is that there's another kind of inflammation. It's the same inflammation,

66
00:03:38,200 --> 00:03:42,520
Speaker 2: but there's just different parameters to it that take it

67
00:03:42,560 --> 00:03:45,440
Speaker 2: from being like a really important part of a healthy

68
00:03:45,480 --> 00:03:50,160
Speaker 2: immune system and turn it into a thing that will

69
00:03:50,240 --> 00:03:55,360
Speaker 2: kill you basically over time. And it's actually they're finding

70
00:03:55,400 --> 00:04:00,520
Speaker 2: that inflammation is a common factor in so many different diseases,

71
00:04:00,560 --> 00:04:09,280
Speaker 2: from heart disease to depression to diabetes, all sorts of stuff,

72
00:04:09,320 --> 00:04:12,520
Speaker 2: I mean, just the gamut types of cancer. That there's

73
00:04:12,880 --> 00:04:16,679
Speaker 2: they basically come up with a new unifying theory of disease,

74
00:04:16,720 --> 00:04:20,000
Speaker 2: the inflammation theory of disease that if you if you

75
00:04:20,080 --> 00:04:24,760
Speaker 2: look close enough, in almost any especially noncommunicable diseases, but

76
00:04:24,839 --> 00:04:29,040
Speaker 2: those two there, there's inflammation and that that's really what's

77
00:04:29,040 --> 00:04:29,960
Speaker 2: screwing you up.

78
00:04:30,640 --> 00:04:36,160
Speaker 1: Yeah, that's it. Goodbye, goodbye. Yeah. It's called chronic inflammation.

79
00:04:36,360 --> 00:04:39,640
Speaker 1: And the word inflammation and big thanks to Dave Ruse,

80
00:04:39,920 --> 00:04:42,239
Speaker 1: yeah for this. This is very thorough.

81
00:04:42,279 --> 00:04:44,400
Speaker 2: I thought of biblical time machine fame.

82
00:04:44,680 --> 00:04:49,599
Speaker 1: That's right. The word inflammation is Latin and root of

83
00:04:49,600 --> 00:04:53,880
Speaker 1: course in flammatio, and it means to ignite or to

84
00:04:53,960 --> 00:04:57,640
Speaker 1: set fire in Latin. And that is really kind of

85
00:04:57,960 --> 00:05:00,320
Speaker 1: straight down the middle as far as what inflammation and

86
00:05:00,360 --> 00:05:06,279
Speaker 1: feels like, and in fact, the descriptors of the four characteristics,

87
00:05:06,520 --> 00:05:09,600
Speaker 1: and we'll touch on the fifth of inflammation goes all

88
00:05:09,640 --> 00:05:13,320
Speaker 1: the way back to our old buddy Galen, the Roman

89
00:05:13,480 --> 00:05:15,320
Speaker 1: physician from the first century AD.

90
00:05:15,680 --> 00:05:18,440
Speaker 2: He pops up almost as much as our friend Pliny.

91
00:05:19,160 --> 00:05:21,240
Speaker 1: Did they know each other, Were they contemporaries?

92
00:05:22,640 --> 00:05:26,240
Speaker 2: There's plenty I don't. Well, Pliny was in the first

93
00:05:26,960 --> 00:05:30,400
Speaker 2: half of the first century, I think, and yeah, I think. Yeah,

94
00:05:30,480 --> 00:05:31,800
Speaker 2: they were probably good friends.

95
00:05:32,000 --> 00:05:33,400
Speaker 1: They were drinking buddies.

96
00:05:33,480 --> 00:05:35,320
Speaker 2: They probably played cornhole together.

97
00:05:37,320 --> 00:05:42,080
Speaker 1: That has many implications. I know, they might beat beer drinkers,

98
00:05:42,960 --> 00:05:44,680
Speaker 1: they might have their Saturday spree.

99
00:05:45,400 --> 00:05:45,840
Speaker 2: What else.

100
00:05:46,160 --> 00:05:50,640
Speaker 1: They might be handy with a saw so they build

101
00:05:50,680 --> 00:05:54,120
Speaker 1: their own. Sure, they may like football games and tailgating.

102
00:05:54,520 --> 00:05:58,560
Speaker 2: Yeah, there was a lot wrapped up in corn hole playing. Yeah.

103
00:05:58,640 --> 00:06:00,599
Speaker 1: So Galen is the one who who kind of nailed

104
00:06:00,600 --> 00:06:02,800
Speaker 1: it out of the gate way back then and said

105
00:06:02,839 --> 00:06:06,479
Speaker 1: that if you are inflamed, you will have redness, you

106
00:06:06,560 --> 00:06:09,960
Speaker 1: have swelling, Sure, you will have heat check, you will

107
00:06:10,000 --> 00:06:14,760
Speaker 1: have pain out, and then you have My friend Josh

108
00:06:14,839 --> 00:06:19,000
Speaker 1: emailed me today and just saying no, Josh Clark and

109
00:06:19,080 --> 00:06:22,960
Speaker 1: said that there's also a fifth one, buddy, and you

110
00:06:23,040 --> 00:06:25,040
Speaker 1: have loss of function. But I'm going to amend your

111
00:06:25,200 --> 00:06:29,120
Speaker 1: email to impaired function, okay for reduced function.

112
00:06:29,480 --> 00:06:31,960
Speaker 2: Yeah, which is like if you have if you have

113
00:06:32,040 --> 00:06:35,760
Speaker 2: that sprained ankle and it's inflamed, you're not walking around

114
00:06:35,760 --> 00:06:38,359
Speaker 2: on that ankle, you're basically not using it for the

115
00:06:38,400 --> 00:06:41,480
Speaker 2: time being, or you're barely, very gingerly using it. So yeah,

116
00:06:41,640 --> 00:06:44,680
Speaker 2: impaired function makes actually a lot more sense. Way to go.

117
00:06:45,320 --> 00:06:48,200
Speaker 1: Sure, and this is all good stuff like this acute inflammation.

118
00:06:48,600 --> 00:06:50,680
Speaker 1: And we've talked about it before plenty of times, and

119
00:06:51,880 --> 00:06:57,440
Speaker 1: oh boy, lots of podcasts pollin autoimmune disorders, like actually

120
00:06:57,480 --> 00:06:59,440
Speaker 1: autoimmune you probably touched on it, but that's as we'll

121
00:06:59,440 --> 00:07:03,280
Speaker 1: see a different thing. But acute inflammation is a good thing.

122
00:07:03,320 --> 00:07:06,640
Speaker 1: This is when your body mounts a defense and you know,

123
00:07:06,680 --> 00:07:09,560
Speaker 1: if you sprain that ankle, or if you cut your hand,

124
00:07:10,200 --> 00:07:14,400
Speaker 1: or if you have stripped throat or something, then your

125
00:07:14,440 --> 00:07:17,280
Speaker 1: body basically says, all right, you know, we need to

126
00:07:17,320 --> 00:07:21,040
Speaker 1: go to that wound with a lot of stuff with

127
00:07:21,560 --> 00:07:26,240
Speaker 1: T cells, with B cells. I think they're basically all

128
00:07:26,320 --> 00:07:29,520
Speaker 1: lumped into this group called inflammatory mediators.

129
00:07:29,040 --> 00:07:33,640
Speaker 2: Right, yeah, well they are the ones that release inflammatory mediators,

130
00:07:33,680 --> 00:07:35,640
Speaker 2: I believe, So like these are the cells that go

131
00:07:35,680 --> 00:07:38,720
Speaker 2: and do stuff like eat other cells or eat pathogens

132
00:07:38,720 --> 00:07:41,160
Speaker 2: and spit them out or carry them into the lymph nodes.

133
00:07:41,480 --> 00:07:44,280
Speaker 2: But the inflammatory mediators are what they release, and those

134
00:07:44,320 --> 00:07:48,520
Speaker 2: are like hormones like histamines and brady Kinan's right. And

135
00:07:48,560 --> 00:07:52,000
Speaker 2: then those mediators are the ones that are actually having

136
00:07:52,080 --> 00:07:54,680
Speaker 2: like effects on your body. They're the ones that like

137
00:07:55,240 --> 00:07:58,960
Speaker 2: dilate your blood vessels to bring more blood to the area,

138
00:07:59,000 --> 00:08:04,320
Speaker 2: which makes itmer and red or they also they also

139
00:08:04,440 --> 00:08:07,880
Speaker 2: irritate your nerve endings, so that's where the pain comes from.

140
00:08:08,480 --> 00:08:10,600
Speaker 2: That's the mediators that are doing all the stuff that

141
00:08:10,640 --> 00:08:15,040
Speaker 2: your body is experiencing as like acute inflammation. But they're

142
00:08:15,040 --> 00:08:18,360
Speaker 2: brought to that site, I believe, by white blood cells, right.

143
00:08:18,560 --> 00:08:20,480
Speaker 1: And the reason and we're saying it kind of like

144
00:08:20,520 --> 00:08:23,440
Speaker 1: everyone knows, because I think everyone kind of knows this, sure,

145
00:08:23,520 --> 00:08:27,520
Speaker 1: But the reason why your capillaries are expanding around the

146
00:08:27,800 --> 00:08:30,560
Speaker 1: ankle sprain or around the cut or whatever is is

147
00:08:30,600 --> 00:08:33,400
Speaker 1: basically just saying like, hey, we need to get more

148
00:08:33,440 --> 00:08:35,960
Speaker 1: blood there, so take the express train. We're gonna puff

149
00:08:36,040 --> 00:08:40,040
Speaker 1: up and no stopping along the way, and let's just

150
00:08:40,160 --> 00:08:41,920
Speaker 1: get as much good stuff in there as fast as

151
00:08:41,960 --> 00:08:42,280
Speaker 1: we can.

152
00:08:42,600 --> 00:08:46,360
Speaker 2: Yeah, which also accounts for fluid collection, which is another

153
00:08:46,480 --> 00:08:51,880
Speaker 2: kind of sub feature of inflammation, which which I've never

154
00:08:51,920 --> 00:08:55,920
Speaker 2: really thought of before, but it makes sense. And then consequently,

155
00:08:55,960 --> 00:08:57,960
Speaker 2: your lymph note do you know when those get kind

156
00:08:57,960 --> 00:09:01,679
Speaker 2: of swollen when you're sick, that's because all that inflame

157
00:09:01,880 --> 00:09:05,600
Speaker 2: stuff that those macrofages are eating and carrying out take

158
00:09:05,600 --> 00:09:07,920
Speaker 2: them to the lymph nodes, and your lift notes get

159
00:09:08,000 --> 00:09:12,080
Speaker 2: swollen from over work and eventually go back down once

160
00:09:12,120 --> 00:09:14,400
Speaker 2: they drain out all of that crud. And the same

161
00:09:14,440 --> 00:09:16,719
Speaker 2: thing to you also chuck for your running nose.

162
00:09:17,760 --> 00:09:19,360
Speaker 1: My running knows that I have right now.

163
00:09:19,600 --> 00:09:24,880
Speaker 2: Yes, it's because your mucous membranes are inflamed, and by

164
00:09:24,920 --> 00:09:29,480
Speaker 2: bringing more fluid to the site, it's easier to more

165
00:09:29,559 --> 00:09:31,400
Speaker 2: quickly flush out all that crud.

166
00:09:32,000 --> 00:09:34,439
Speaker 1: Yeah. Do you remember when I went to the hospital

167
00:09:34,480 --> 00:09:38,240
Speaker 1: in New York when we were had our initial book

168
00:09:39,440 --> 00:09:41,240
Speaker 1: push that didn't become the book.

169
00:09:41,080 --> 00:09:43,400
Speaker 2: Yeah, with our buddy Steven. I was thinking about it.

170
00:09:43,440 --> 00:09:44,440
Speaker 2: Not a week ago.

171
00:09:44,480 --> 00:09:48,920
Speaker 1: Really, Yeah, So remember I went to the hospital. What

172
00:09:48,960 --> 00:09:50,679
Speaker 1: hospital was it, I can't remember, you know, one of

173
00:09:50,720 --> 00:09:54,719
Speaker 1: the New York City hospitals, right like Manhattan. Yeah, it

174
00:09:54,760 --> 00:09:56,400
Speaker 1: was what did I end up having I can't even

175
00:09:56,400 --> 00:09:57,000
Speaker 1: remember now.

176
00:09:57,280 --> 00:09:59,480
Speaker 2: I thought it was like a like some sort of

177
00:09:59,559 --> 00:10:01,600
Speaker 2: terrible astritis or something like that.

178
00:10:01,800 --> 00:10:05,040
Speaker 1: I don't remember. That probably blocked it out of my mind.

179
00:10:05,600 --> 00:10:08,000
Speaker 1: But long story short, after they had sort of healed

180
00:10:08,040 --> 00:10:09,320
Speaker 1: me from this and they were like, all right, you

181
00:10:09,320 --> 00:10:13,240
Speaker 1: can go. And I woke up from my drug induced

182
00:10:13,240 --> 00:10:16,320
Speaker 1: stupor in my hospital bed. I felt behind my ear

183
00:10:17,000 --> 00:10:20,319
Speaker 1: and I had a like a ping pong ball behind

184
00:10:20,320 --> 00:10:20,920
Speaker 1: my ear.

185
00:10:20,840 --> 00:10:22,840
Speaker 2: And I was like so disconcerting, what is this?

186
00:10:23,520 --> 00:10:25,600
Speaker 1: And I would go to the nurse and I was like, hey, man,

187
00:10:25,679 --> 00:10:29,800
Speaker 1: what is hair Bab Sammy Davis Junior hair Bab? I

188
00:10:29,840 --> 00:10:33,640
Speaker 1: have a golf ball behind my ear? And he he was.

189
00:10:33,760 --> 00:10:35,040
Speaker 1: He kind of gave me a look like what is

190
00:10:35,080 --> 00:10:38,320
Speaker 1: it with you? Like are you a hypochondriac? And I

191
00:10:38,360 --> 00:10:41,079
Speaker 1: was like, no, dude, look at it. It's huge. And

192
00:10:41,120 --> 00:10:42,760
Speaker 1: I think he could just sort of dismissed it and

193
00:10:42,800 --> 00:10:44,199
Speaker 1: was like, yeah, it's probably just some sort of a

194
00:10:44,240 --> 00:10:49,080
Speaker 1: swollen node from whatever this was, and you don't worry

195
00:10:49,080 --> 00:10:49,480
Speaker 1: about it.

196
00:10:49,679 --> 00:10:51,640
Speaker 2: Yeah. No, I remember you coming to lunch and being

197
00:10:51,679 --> 00:10:55,360
Speaker 2: like I was just roundly mistreated by like this nurse.

198
00:10:55,360 --> 00:10:57,640
Speaker 1: Who was he was great actually, but he was just

199
00:10:57,679 --> 00:11:00,600
Speaker 1: basically like, don't sweat it, please leave. We need Yeah,

200
00:11:00,640 --> 00:11:04,600
Speaker 1: for sure, But anyway, that was my body again, just

201
00:11:04,679 --> 00:11:07,119
Speaker 1: puffing up when something happened exactly.

202
00:11:07,320 --> 00:11:10,280
Speaker 2: So that's part of your acute immune response. You get

203
00:11:10,320 --> 00:11:13,600
Speaker 2: dilated blood vessels, you get more blood there, it's easier

204
00:11:13,600 --> 00:11:15,439
Speaker 2: for the white blood cells to get in and out

205
00:11:15,480 --> 00:11:18,080
Speaker 2: of those vessels. You got irritated, nurse, you have pain,

206
00:11:18,120 --> 00:11:21,400
Speaker 2: you got fluid collecting all the stuff that happens when

207
00:11:21,440 --> 00:11:24,840
Speaker 2: you cut yourself or you sprain an ankle. I don't

208
00:11:24,880 --> 00:11:26,200
Speaker 2: know why I keep going to that, but it's a

209
00:11:26,240 --> 00:11:30,480
Speaker 2: good one. It's a good one, and that's normal. That's

210
00:11:30,760 --> 00:11:35,439
Speaker 2: your acute immune inflammatory response. Is that's a normal part

211
00:11:35,559 --> 00:11:38,439
Speaker 2: of getting rid of a pathogen or treating an injury

212
00:11:38,679 --> 00:11:40,880
Speaker 2: or a good thing like that. Yeah, your body's under

213
00:11:40,960 --> 00:11:44,040
Speaker 2: some sort of stress and your immune system goes swarm

214
00:11:44,160 --> 00:11:48,120
Speaker 2: swarm and inflames the area to help repair it more.

215
00:11:48,320 --> 00:11:51,440
Speaker 2: It also one of the reasons why it gets warm

216
00:11:51,800 --> 00:11:53,640
Speaker 2: and one of the reasons also why you might feel

217
00:11:53,679 --> 00:11:56,679
Speaker 2: tired if you have a particularly bad infection, is because

218
00:11:56,720 --> 00:11:59,800
Speaker 2: your body is diverting a lot of your energy and

219
00:12:00,080 --> 00:12:04,280
Speaker 2: tabolism too, fighting off whatever that is or treating that site,

220
00:12:04,360 --> 00:12:07,439
Speaker 2: whatever it is, so you don't have like the energy

221
00:12:07,520 --> 00:12:12,040
Speaker 2: to do cartwheels or anything because it's being used otherwise, again,

222
00:12:12,520 --> 00:12:16,440
Speaker 2: totally normal. The problem is is if this keeps going on,

223
00:12:17,280 --> 00:12:19,959
Speaker 2: even if it drops down to a lower level, if

224
00:12:20,000 --> 00:12:24,320
Speaker 2: it continues long after it should have stopped, now you've

225
00:12:24,320 --> 00:12:27,640
Speaker 2: got problems. And this is the basis of that unified

226
00:12:27,679 --> 00:12:31,760
Speaker 2: theory of disease, that chronic inflammation, systemic chronic inflammation that

227
00:12:31,760 --> 00:12:32,520
Speaker 2: you're talking about.

228
00:12:32,920 --> 00:12:40,200
Speaker 1: Yeah, sci or ci ski Ski that's what they call them.

229
00:12:40,200 --> 00:12:42,880
Speaker 1: The BIZ Sure one example of this, and we're going

230
00:12:42,920 --> 00:12:45,640
Speaker 1: to go over a lot of different examples, but one

231
00:12:45,720 --> 00:12:48,520
Speaker 1: example is, you know, sometimes you have infections that don't

232
00:12:48,559 --> 00:12:51,720
Speaker 1: go away and your body mounts that immune response, but

233
00:12:51,760 --> 00:12:55,200
Speaker 1: it's not just like, okay, we cured your or we

234
00:12:55,240 --> 00:12:57,120
Speaker 1: got rid of your bronchitis for an now or whatever.

235
00:12:58,000 --> 00:13:02,160
Speaker 1: There are long term infections that are very persistent. Hepatitis

236
00:13:02,200 --> 00:13:06,800
Speaker 1: is one, HIV is another, they think long COVID maybe another.

237
00:13:07,400 --> 00:13:11,280
Speaker 1: Where your body has this immune response and it mounts it,

238
00:13:11,920 --> 00:13:14,600
Speaker 1: but it doesn't go away completely, so it doesn't wipe

239
00:13:14,640 --> 00:13:18,240
Speaker 1: out all those pathogens and so it just stays around.

240
00:13:18,280 --> 00:13:22,439
Speaker 1: So your body has sort of a low level inflammatory

241
00:13:22,559 --> 00:13:26,400
Speaker 1: response always happening in the case of these long term infections,

242
00:13:26,920 --> 00:13:30,080
Speaker 1: and your body is just sort of constantly trying to

243
00:13:30,120 --> 00:13:30,520
Speaker 1: fight it.

244
00:13:31,120 --> 00:13:34,559
Speaker 2: Right, So that's one that's a you can at least

245
00:13:34,559 --> 00:13:38,120
Speaker 2: trace it back to a cause in that instance. Right. Yes,

246
00:13:38,480 --> 00:13:42,199
Speaker 2: there's another thing that triggers chronic systemic chronic inflammation. That's

247
00:13:42,240 --> 00:13:46,000
Speaker 2: oxidative stress, which we talked about in our Free Radicals episode.

248
00:13:46,040 --> 00:13:48,960
Speaker 2: Is the free radical theory of aging. Wrong, Remember it

249
00:13:49,000 --> 00:13:50,560
Speaker 2: came out but in the last couple of years.

250
00:13:50,640 --> 00:13:51,360
Speaker 1: Right, it's a good one.

251
00:13:51,600 --> 00:13:54,600
Speaker 2: Yeah, it was. But we talked about oxidative stress, which

252
00:13:54,640 --> 00:14:00,480
Speaker 2: is where free radicals these radically free little molecules that

253
00:14:01,120 --> 00:14:05,960
Speaker 2: borrow electrons from whatever is around it. They're super reactive molecules,

254
00:14:06,360 --> 00:14:09,680
Speaker 2: and by borrowing an electron, that cell or that other

255
00:14:09,800 --> 00:14:15,120
Speaker 2: molecule needed that electron. So it's now in disrepair, it's

256
00:14:15,120 --> 00:14:18,880
Speaker 2: not functioning correctly, maybe it's dying. It's a problem. And

257
00:14:19,120 --> 00:14:24,880
Speaker 2: free radicals another term from is reactive oxidative species, reactive

258
00:14:24,880 --> 00:14:29,200
Speaker 2: oxygen species. I think they're normal, like we produce those

259
00:14:29,280 --> 00:14:34,119
Speaker 2: just from everything from like breathing to the immune system. Right,

260
00:14:34,200 --> 00:14:38,080
Speaker 2: but they're supposed to be in balance. We have antioxidants

261
00:14:38,160 --> 00:14:40,840
Speaker 2: naturally produced, and we can also absorb them from food

262
00:14:41,040 --> 00:14:43,680
Speaker 2: that neutralize them. They go up to them, they say,

263
00:14:43,720 --> 00:14:46,640
Speaker 2: take my electron, and they're now neutralized. They're not going

264
00:14:46,720 --> 00:14:48,880
Speaker 2: to take it from a nearby cell or something like that.

265
00:14:49,120 --> 00:14:52,600
Speaker 2: If that gets out of balance, you've got oxidative stress

266
00:14:53,040 --> 00:14:56,400
Speaker 2: where you have more cells than you should being damaged

267
00:14:56,400 --> 00:14:58,880
Speaker 2: by these free radicals because you have more free radicals

268
00:14:58,880 --> 00:15:02,000
Speaker 2: than you should. And then the immune response says, we

269
00:15:02,120 --> 00:15:05,000
Speaker 2: got a problem over there. Let's get this area inflamed.

270
00:15:05,520 --> 00:15:09,760
Speaker 2: That's right, and that's oxidative stress. That's another reason that

271
00:15:09,800 --> 00:15:14,160
Speaker 2: you could point to for systemic chronic inflammation. The problem

272
00:15:14,240 --> 00:15:17,840
Speaker 2: is chuck. There's also there's also types of chronic inflammation

273
00:15:18,160 --> 00:15:22,920
Speaker 2: that have no reason whatsoever, like the body's just not

274
00:15:23,280 --> 00:15:25,960
Speaker 2: doing what it's supposed to do. It's basically confused in

275
00:15:26,080 --> 00:15:27,480
Speaker 2: your suffering as a result.

276
00:15:28,000 --> 00:15:32,080
Speaker 1: Yeah, and we talked about, you know, autoimmune disorders, and

277
00:15:33,480 --> 00:15:35,680
Speaker 1: we haven't done one on rum it's what arthritis yet,

278
00:15:35,680 --> 00:15:36,800
Speaker 1: but I think that's probably coming.

279
00:15:37,080 --> 00:15:37,360
Speaker 2: Sure.

280
00:15:37,720 --> 00:15:41,280
Speaker 1: Lupus is another example. I mean, we talked about allergies

281
00:15:41,320 --> 00:15:46,880
Speaker 1: and how that's that's an overblown immune response to yourself. Yeah,

282
00:15:47,360 --> 00:15:49,680
Speaker 1: so in these cases, you're you know, your white blood

283
00:15:49,680 --> 00:15:53,640
Speaker 1: cells are being dispatched to you know, whatever you would

284
00:15:53,680 --> 00:15:57,400
Speaker 1: consider like the point of origin. I guess, and the

285
00:15:57,440 --> 00:15:59,480
Speaker 1: body makes a mistake and said, all right, well I

286
00:15:59,520 --> 00:16:04,000
Speaker 1: gotta I gotta start inflaming myself, and it inflames healthy

287
00:16:04,040 --> 00:16:07,880
Speaker 1: tissues and healthy organs, and a lot of damage can

288
00:16:07,920 --> 00:16:10,200
Speaker 1: be caused in a big, big way.

289
00:16:10,680 --> 00:16:15,080
Speaker 2: Yeah, because again, like this immune response, this inflammation shouldn't

290
00:16:15,120 --> 00:16:19,480
Speaker 2: be happening anyway. It's targeting healthy stuff. It's turned on itself.

291
00:16:19,520 --> 00:16:22,920
Speaker 2: Your body's turned on itself. That's problematic in and of itself.

292
00:16:23,200 --> 00:16:26,640
Speaker 2: But because your body's still producing all the same things

293
00:16:26,680 --> 00:16:29,440
Speaker 2: that your immune system is now mistaking as like foreign

294
00:16:29,440 --> 00:16:33,960
Speaker 2: invaders or pathogens, it's constantly going to be mounting this

295
00:16:34,120 --> 00:16:38,600
Speaker 2: inflammatory response, and so you're going to have systemic chronic

296
00:16:38,640 --> 00:16:40,120
Speaker 2: inflammation from that as well.

297
00:16:40,760 --> 00:16:42,640
Speaker 1: All right, shall we take a break, I think so

298
00:16:43,240 --> 00:16:45,280
Speaker 1: all right, we're gonna take a break. I'm gonna move

299
00:16:45,280 --> 00:16:49,520
Speaker 1: into the new studio. Oh wait, best tomorrow, sorry very eager.

300
00:16:49,720 --> 00:17:19,800
Speaker 1: Oh wait, we'll be right back. All right, So we're

301
00:17:19,840 --> 00:17:24,280
Speaker 1: back talking inflammation. This is Inflammatalk with Josh and Chuck

302
00:17:25,240 --> 00:17:30,400
Speaker 1: and not every chronic disease or everything that can kill

303
00:17:30,440 --> 00:17:34,199
Speaker 1: you is linked to chronic inflammation. But yeah, you go

304
00:17:34,320 --> 00:17:39,080
Speaker 1: over the list, it's like the most the major killers

305
00:17:39,160 --> 00:17:43,480
Speaker 1: of humans you can usually link to chronic inflammation, high

306
00:17:43,520 --> 00:17:51,000
Speaker 1: blood pressure, heart disease, type two diabetes, chronic kidney disease, IBS. Inflammatory,

307
00:17:51,040 --> 00:17:54,840
Speaker 1: the word is even in there, inflammatory, bowel disease, asthma.

308
00:17:55,640 --> 00:17:59,520
Speaker 1: Other you know, we'll talk about lung cancer later and

309
00:17:59,640 --> 00:18:02,040
Speaker 1: colon cancer later, but those are a couple of kinds

310
00:18:02,040 --> 00:18:07,840
Speaker 1: of cancer. We mentioned rheumatoid arthritis. But there are some

311
00:18:07,880 --> 00:18:10,040
Speaker 1: surprising things in here that we're going to go over

312
00:18:10,040 --> 00:18:13,320
Speaker 1: here in a few minutes. What is depression, Another is

313
00:18:13,400 --> 00:18:17,920
Speaker 1: Parkinson's and dementia yep. And then the final one on

314
00:18:18,119 --> 00:18:21,400
Speaker 1: Dave's list, it's a very thorough list, is non alcoholic

315
00:18:21,440 --> 00:18:24,959
Speaker 1: fatty liver disease. And this is basically, you know, all

316
00:18:25,000 --> 00:18:27,960
Speaker 1: the doctors have gotten together now, they all got together

317
00:18:28,000 --> 00:18:31,800
Speaker 1: in one room and they said, we've got a situation

318
00:18:31,880 --> 00:18:35,320
Speaker 1: on our hands where we can officially all agree, like

319
00:18:36,080 --> 00:18:41,480
Speaker 1: the inflammation theory of disease is sort of coalescing, and

320
00:18:41,560 --> 00:18:42,879
Speaker 1: we we're pretty sure about all this.

321
00:18:43,280 --> 00:18:46,240
Speaker 2: Right, there's an outstanding chicken or the egg question though,

322
00:18:46,280 --> 00:18:49,720
Speaker 2: that they've yet to answer, and that is the inflammation.

323
00:18:49,920 --> 00:18:53,600
Speaker 2: Is chronic inflammation the cause of these chronic diseases or

324
00:18:53,640 --> 00:18:56,159
Speaker 2: is it a symptom of these chronic diseases And they

325
00:18:56,200 --> 00:18:58,800
Speaker 2: don't know yet. I'm going to put a substantial amount

326
00:18:58,840 --> 00:19:02,040
Speaker 2: of my money on it's the cause. Yeah, I don't

327
00:19:02,040 --> 00:19:03,760
Speaker 2: think it's the symptom. I think the way that we've

328
00:19:03,800 --> 00:19:08,600
Speaker 2: been approaching disease is the idea that inflammation would be

329
00:19:08,640 --> 00:19:12,560
Speaker 2: a symptom of it, like you have some problem, some

330
00:19:12,720 --> 00:19:16,159
Speaker 2: external problem that's coming into your body that's causing wreaking

331
00:19:16,160 --> 00:19:19,320
Speaker 2: all this havoc. It's actually not right. So let's say

332
00:19:19,320 --> 00:19:21,520
Speaker 2: you're talking about sugar. You eat a bunch of sugar.

333
00:19:21,760 --> 00:19:24,840
Speaker 2: The sugar itself is not causing problems in your body.

334
00:19:25,000 --> 00:19:29,320
Speaker 2: The sugar is triggering inflammation and chronic inflammation in some cases,

335
00:19:29,520 --> 00:19:32,600
Speaker 2: and that's the problem. That doesn't mean sugar is blameless

336
00:19:32,800 --> 00:19:35,480
Speaker 2: because your body's still responding to it and it's it's

337
00:19:35,640 --> 00:19:37,560
Speaker 2: just going to do that every time you eat sugar.

338
00:19:38,000 --> 00:19:41,439
Speaker 2: But it's not the sugar itself. So I think the

339
00:19:41,560 --> 00:19:43,840
Speaker 2: inflammation is the cause of the disease.

340
00:19:44,760 --> 00:19:48,159
Speaker 1: Yeah, I think I'm with you. Let's go over this

341
00:19:48,200 --> 00:19:52,040
Speaker 1: first really interesting example of something that we kind of

342
00:19:52,040 --> 00:19:54,280
Speaker 1: thought we had figured out and now we know so

343
00:19:54,359 --> 00:19:58,800
Speaker 1: much more about, and that is Alzheimer's disease. I'll give

344
00:19:58,800 --> 00:20:02,360
Speaker 1: you a we've do we do one specifically on Alzheimer's.

345
00:20:03,640 --> 00:20:06,080
Speaker 2: I think it was dementia. I don't. I think it

346
00:20:06,200 --> 00:20:07,920
Speaker 2: was I don't. I don't remember.

347
00:20:08,200 --> 00:20:09,720
Speaker 1: Okay, well, I know we've talked about it. But the

348
00:20:09,760 --> 00:20:14,040
Speaker 1: quickest refresher Alzheimer's is a type of dementia, and it's

349
00:20:14,040 --> 00:20:16,200
Speaker 1: neuronal death. Is what's going on. We have a couple

350
00:20:16,280 --> 00:20:20,119
Speaker 1: of things in the brain that function well until they don't.

351
00:20:20,920 --> 00:20:24,640
Speaker 1: One is called amyloid beta proteins. These are little clusters

352
00:20:24,680 --> 00:20:27,680
Speaker 1: around your neurons in a healthy brain, and they aid

353
00:20:27,840 --> 00:20:31,359
Speaker 1: in neural growth and repair, doing a really good job.

354
00:20:31,720 --> 00:20:35,119
Speaker 1: But when they become misfolded, then all of a sudden,

355
00:20:35,240 --> 00:20:39,639
Speaker 1: it becomes We've talked about amyloid plaques, and that's what

356
00:20:39,680 --> 00:20:43,960
Speaker 1: they are. These plaques form and they're basically misfolded versions

357
00:20:44,080 --> 00:20:48,400
Speaker 1: of ordinarily good amyloid beta proteins, and these are outside

358
00:20:48,440 --> 00:20:52,760
Speaker 1: the neurons. There's also something inside the neurons called taulproteins,

359
00:20:53,320 --> 00:20:55,840
Speaker 1: and these are also great. They do great work, big

360
00:20:55,880 --> 00:20:59,840
Speaker 1: fan they aid in neuron structure and kind of keep

361
00:20:59,880 --> 00:21:02,880
Speaker 1: them nice and strong from the inside. But these can

362
00:21:02,920 --> 00:21:07,760
Speaker 1: also become misfolded. But they're misfolded on the inside and

363
00:21:07,840 --> 00:21:10,800
Speaker 1: all of a sudden it becomes what's called a neurofibrillary

364
00:21:10,880 --> 00:21:12,200
Speaker 1: tangle or a towel tangle.

365
00:21:12,280 --> 00:21:13,080
Speaker 2: That sounds bad.

366
00:21:13,480 --> 00:21:16,520
Speaker 1: It does sound bad, And we've known for a while now, like, hey,

367
00:21:16,720 --> 00:21:19,679
Speaker 1: if you have amyloid plaques and these towel tangles in

368
00:21:19,720 --> 00:21:24,919
Speaker 1: your brain, then that is what is causing this Alzheimer's disease,

369
00:21:25,280 --> 00:21:28,280
Speaker 1: the type of dementia. But now they've zeroed in and said,

370
00:21:28,359 --> 00:21:32,720
Speaker 1: you know what, we think it's really this neuroinflammation that's

371
00:21:32,760 --> 00:21:34,840
Speaker 1: going on in the brain that's the real root cause.

372
00:21:35,119 --> 00:21:39,280
Speaker 2: Yeah, that's actually a good example of this inflammatory theory

373
00:21:39,320 --> 00:21:44,160
Speaker 2: of disease. Creating a chicken or egg question about those

374
00:21:44,240 --> 00:21:47,280
Speaker 2: tau tangles and amyloid plaques, Like, we used to think

375
00:21:47,280 --> 00:21:49,280
Speaker 2: that that was the problem, but now is that just

376
00:21:49,320 --> 00:21:53,119
Speaker 2: a symptom of it. We're not sure. But there's a

377
00:21:53,160 --> 00:21:58,959
Speaker 2: couple theories on how neuroinflammation would cause Alzheimer's, specifically and

378
00:21:59,400 --> 00:22:02,040
Speaker 2: one of them is that it's based around microglia cells.

379
00:22:02,320 --> 00:22:05,560
Speaker 2: We talked about macrophasias that go around and eat like pathogens.

380
00:22:06,359 --> 00:22:09,080
Speaker 2: This is the brain's version of that, a really specialized

381
00:22:09,160 --> 00:22:11,680
Speaker 2: version that goes around and like cleans up the brain,

382
00:22:11,720 --> 00:22:16,080
Speaker 2: eating neurons that are problematic or have stopped functioning or

383
00:22:16,080 --> 00:22:18,639
Speaker 2: it's just their time to go. And they do a

384
00:22:18,640 --> 00:22:22,399
Speaker 2: really good job normally, but over time, especially when we

385
00:22:22,440 --> 00:22:27,200
Speaker 2: get old, those microglia can also turn on healthy neurons

386
00:22:27,640 --> 00:22:31,439
Speaker 2: and which would make Alzheimer's and all of the loss

387
00:22:31,440 --> 00:22:37,800
Speaker 2: of function and cognitive ability and behavioral changes in autoimmune condition, right, Yeah,

388
00:22:38,040 --> 00:22:40,879
Speaker 2: which is not exactly what you think of when you

389
00:22:40,920 --> 00:22:42,560
Speaker 2: think of Alzheimer's.

390
00:22:43,040 --> 00:22:46,280
Speaker 1: Yeah, But here's the thing is, they've done some interesting studies.

391
00:22:47,240 --> 00:22:51,560
Speaker 1: They've done autopsies on patients that have, like you know,

392
00:22:51,560 --> 00:22:53,760
Speaker 1: we talked about the build up of these amyloid plaques

393
00:22:53,760 --> 00:22:57,199
Speaker 1: and everyone's like, that's what causes Alzheimer's. They've done autopsies

394
00:22:57,200 --> 00:23:01,439
Speaker 1: on these brains that had really far gone amyloid plaque

395
00:23:01,440 --> 00:23:05,639
Speaker 1: build ups but really not much neuroinflammation going on, and

396
00:23:05,760 --> 00:23:08,600
Speaker 1: the patients had no symptoms of dementia in these cases.

397
00:23:08,920 --> 00:23:10,720
Speaker 2: But I mean, isn't it possible it's just because they

398
00:23:10,760 --> 00:23:13,200
Speaker 2: were dead, they probably didn't have symptoms of anything.

399
00:23:14,960 --> 00:23:20,760
Speaker 1: Very funny, Go ahead, all right, Sorry I was holding

400
00:23:20,760 --> 00:23:24,800
Speaker 1: for applause. But then they looked at patients with not

401
00:23:25,040 --> 00:23:27,920
Speaker 1: very many plaque formations, so you wouldn't think that they

402
00:23:28,000 --> 00:23:32,760
Speaker 1: had dementia or Alzheimer's, but they had really high levels

403
00:23:32,800 --> 00:23:37,240
Speaker 1: of neuroinflammation. And these people had basically all the signs

404
00:23:37,240 --> 00:23:39,960
Speaker 1: and symptoms of advanced Alzheimer's.

405
00:23:40,000 --> 00:23:42,480
Speaker 2: That's pretty good evidence of that theory then.

406
00:23:42,640 --> 00:23:44,320
Speaker 1: I mean, it's kind of a reversal almost.

407
00:23:44,520 --> 00:23:49,000
Speaker 2: Yeah. I saw Another interpretation of the neuroinflammation theory of

408
00:23:49,000 --> 00:23:54,160
Speaker 2: Alzheimer's is that those amyloid plaques and tau tangles, right

409
00:23:54,400 --> 00:23:56,720
Speaker 2: as they build up in the brain, those microglias start

410
00:23:56,800 --> 00:24:00,280
Speaker 2: to attack them and try to clear them out, as

411
00:24:00,400 --> 00:24:04,200
Speaker 2: it should do. But because the brain is constantly after

412
00:24:04,280 --> 00:24:08,440
Speaker 2: a certain age or or whatever, producing these tangles and plaques,

413
00:24:08,960 --> 00:24:13,360
Speaker 2: the microglie are constantly attacking them. So you now have

414
00:24:13,480 --> 00:24:18,840
Speaker 2: chronic chronic inflammation in your brain, which is another explanation

415
00:24:18,920 --> 00:24:21,200
Speaker 2: of neuroinflammation for Alzheimer's.

416
00:24:21,760 --> 00:24:27,720
Speaker 1: Yeah, so like neuronal death happens, let's just face it,

417
00:24:27,960 --> 00:24:31,240
Speaker 1: and it happens more as you age. But like these

418
00:24:31,359 --> 00:24:35,960
Speaker 1: microglia cells that are misidentifying the normal cells. When I

419
00:24:36,000 --> 00:24:40,199
Speaker 1: read this stuff, it feels like science can figure this

420
00:24:40,280 --> 00:24:43,760
Speaker 1: out one day. It feels like they just did well

421
00:24:43,960 --> 00:24:46,600
Speaker 1: figure out how to fix it. Oh yeah, you know,

422
00:24:46,680 --> 00:24:50,119
Speaker 1: I mean, like how to switch something off. And I

423
00:24:50,160 --> 00:24:52,199
Speaker 1: know they're getting close with with with a lot of

424
00:24:52,200 --> 00:24:54,879
Speaker 1: this stuff, but I don't know, like so much of

425
00:24:54,920 --> 00:24:58,520
Speaker 1: this inflammation. As I was reading it, I just kept thinking, like,

426
00:24:58,800 --> 00:25:01,040
Speaker 1: they're going to figure this out at some point.

427
00:25:01,240 --> 00:25:03,679
Speaker 2: Yeah, And I was wondering, So, Chuck, I don't know

428
00:25:03,680 --> 00:25:06,199
Speaker 2: if we said this or not, but there they attribute

429
00:25:06,320 --> 00:25:09,640
Speaker 2: fifty percent of the deaths around the world in any

430
00:25:09,680 --> 00:25:13,920
Speaker 2: given year to chronic inflammation or a disease that is

431
00:25:14,480 --> 00:25:19,240
Speaker 2: connected to chronic inflammation. Right, Yeah, sixty seven million people

432
00:25:19,280 --> 00:25:22,280
Speaker 2: died in twenty twenty two. If they can figure out

433
00:25:22,359 --> 00:25:26,399
Speaker 2: chronic inflammation, you would ostensibly save the lives of thirty

434
00:25:26,400 --> 00:25:29,240
Speaker 2: three and a half million people in a year. Yeah,

435
00:25:29,480 --> 00:25:31,960
Speaker 2: which is amazing. But I'm also wondering, like, isn't that

436
00:25:32,080 --> 00:25:36,720
Speaker 2: gonna cause like one hell of a population crisis if

437
00:25:36,760 --> 00:25:39,400
Speaker 2: we have an extra thirty three million people every year

438
00:25:39,600 --> 00:25:42,560
Speaker 2: that we're going to be there previously, and great, their

439
00:25:42,600 --> 00:25:46,200
Speaker 2: lives are saved. But I guess my point is not like, oh, no,

440
00:25:46,240 --> 00:25:49,240
Speaker 2: they need to die. No, Instead, it's we would actually

441
00:25:49,640 --> 00:25:52,199
Speaker 2: need to prepare and look down the road at how

442
00:25:52,280 --> 00:25:54,199
Speaker 2: to deal with that because it would be a and

443
00:25:54,240 --> 00:25:57,800
Speaker 2: it'd be significant and fast if we figured out chronic inflammation.

444
00:25:58,359 --> 00:26:04,920
Speaker 1: Yeah, calling Norman Borlaw right exactly. Yeah, but something will

445
00:26:05,000 --> 00:26:08,440
Speaker 1: kill you eventually, but you're right, it would extend lives,

446
00:26:08,920 --> 00:26:10,120
Speaker 1: like a lot of lives.

447
00:26:10,000 --> 00:26:12,840
Speaker 2: Vastly and also I mean especially in the case of

448
00:26:12,880 --> 00:26:16,600
Speaker 2: something No, definitely not, but in the case of Alzheimer's especially,

449
00:26:17,480 --> 00:26:20,760
Speaker 2: it would vastly improve later life as well.

450
00:26:20,840 --> 00:26:21,520
Speaker 1: Quality of life.

451
00:26:21,520 --> 00:26:25,200
Speaker 2: Sure, yeah, I mean just like it'd be like night

452
00:26:25,240 --> 00:26:27,800
Speaker 2: and day if we could figure out chronic inflammation, even

453
00:26:27,840 --> 00:26:29,080
Speaker 2: for just Alzheimer's.

454
00:26:29,200 --> 00:26:31,320
Speaker 1: Yeah, I mean, well, I mean quality of life for

455
00:26:31,400 --> 00:26:34,719
Speaker 1: most of these if you talk about something like IBS

456
00:26:34,840 --> 00:26:39,040
Speaker 1: or Crohn's disease, like so much of this stuff is, yeah,

457
00:26:39,160 --> 00:26:41,760
Speaker 1: stuff that people these chronic conditions people just live with

458
00:26:41,840 --> 00:26:43,400
Speaker 1: every day that makes their life miserable.

459
00:26:43,800 --> 00:26:48,560
Speaker 2: Yeah. And if you're one of those fiscal conservatives and

460
00:26:48,600 --> 00:26:50,439
Speaker 2: you're like I don't care about any of this. How

461
00:26:50,440 --> 00:26:52,680
Speaker 2: does this? How are you going to make me care?

462
00:26:53,680 --> 00:26:59,119
Speaker 2: Buckle up? In twenty sixteen, just that year, just in

463
00:26:59,160 --> 00:27:03,400
Speaker 2: the United States, we spent one point one trillion dollars

464
00:27:03,600 --> 00:27:10,760
Speaker 2: directly on healthcare for diseases associated with chronic inflammation. Indirectly,

465
00:27:10,800 --> 00:27:13,040
Speaker 2: if you take like lost productivity and all that stuff

466
00:27:13,040 --> 00:27:16,959
Speaker 2: into account, it cost us three point seven trillion dollars

467
00:27:17,000 --> 00:27:19,800
Speaker 2: in twenty sixteen. Think about what you could do with

468
00:27:19,840 --> 00:27:23,520
Speaker 2: three point seven trillion dollars that you just suddenly had

469
00:27:23,600 --> 00:27:26,000
Speaker 2: in your pocket because we figured out chronic inflammation.

470
00:27:26,760 --> 00:27:28,160
Speaker 1: Yeah, we'd all just get that back, right.

471
00:27:28,520 --> 00:27:31,480
Speaker 2: Sure, they just distributed it to everyone, and we would

472
00:27:31,480 --> 00:27:33,360
Speaker 2: never have to work again, and things would just keep

473
00:27:33,359 --> 00:27:34,240
Speaker 2: going on smoothly.

474
00:27:34,720 --> 00:27:37,359
Speaker 1: You know what they in the business they call what

475
00:27:37,400 --> 00:27:39,919
Speaker 1: you just did? What hit him in the pocketbook?

476
00:27:41,200 --> 00:27:43,679
Speaker 2: Yeah, that makes sense. That's a pretty good term for that.

477
00:27:44,040 --> 00:27:46,280
Speaker 1: Yeah, I'll go. People still say pocketbook, right, that's a

478
00:27:46,520 --> 00:27:49,000
Speaker 1: modern relevant term. Yeah, Oh, I forgot my.

479
00:27:48,960 --> 00:27:51,560
Speaker 2: Pocketbook right in my goloshes.

480
00:27:51,400 --> 00:27:54,440
Speaker 1: My goloshes, my pocketbook. Do people not say goloshes where

481
00:27:54,440 --> 00:27:55,080
Speaker 1: they say wellies?

482
00:27:55,680 --> 00:28:00,000
Speaker 2: Yeah, they say wellies. Now, they definitely don't say rubbers anymore.

483
00:28:00,119 --> 00:28:01,480
Speaker 2: That was always weird.

484
00:28:01,520 --> 00:28:04,359
Speaker 1: I think yeah, I think that ended in like the

485
00:28:04,400 --> 00:28:05,359
Speaker 1: seventies or something.

486
00:28:05,520 --> 00:28:05,960
Speaker 2: Probably.

487
00:28:07,520 --> 00:28:09,480
Speaker 1: I don't feel like we should take our next break yet.

488
00:28:09,480 --> 00:28:11,760
Speaker 1: Do you should we talk about cancer first?

489
00:28:11,880 --> 00:28:15,800
Speaker 2: Hold on, I'm looking inside myself. No, I don't think

490
00:28:15,800 --> 00:28:16,520
Speaker 2: we should either.

491
00:28:16,840 --> 00:28:20,119
Speaker 1: Okay, well let's talk about cancer. We can start it

492
00:28:20,119 --> 00:28:23,439
Speaker 1: out with lung cancer. Everyone knows that when you smoke,

493
00:28:24,000 --> 00:28:26,520
Speaker 1: you have a pretty decent chance of getting lung cancer.

494
00:28:27,640 --> 00:28:29,960
Speaker 1: The question is like, what exactly is going on there?

495
00:28:30,000 --> 00:28:33,760
Speaker 1: And it's pretty easy. You inhale smoke along with other

496
00:28:33,800 --> 00:28:37,239
Speaker 1: things that are in cigarettes, and that really is going

497
00:28:37,280 --> 00:28:40,080
Speaker 1: to irritate the cells inside your lungs. That's going to

498
00:28:40,080 --> 00:28:43,000
Speaker 1: trigger that inflammatory response because your body is like, what

499
00:28:43,160 --> 00:28:45,160
Speaker 1: is going on? I shouldn't have this thing in my lungs?

500
00:28:45,760 --> 00:28:47,640
Speaker 1: And if you do this for years and years and years,

501
00:28:47,920 --> 00:28:50,680
Speaker 1: that's called chronic inflammation, and it's going to damage your

502
00:28:50,720 --> 00:28:51,800
Speaker 1: lung tissues over time.

503
00:28:52,200 --> 00:28:56,960
Speaker 2: Tissues tissue tissue. Sure, But the mechanism even further on,

504
00:28:57,040 --> 00:29:02,240
Speaker 2: like a deeper basis, is that smoke contains reactive oxygen species.

505
00:29:02,800 --> 00:29:06,000
Speaker 2: So that's going and running buck wild through your lung

506
00:29:06,000 --> 00:29:08,920
Speaker 2: tissue tearing stuff up. So not only is it messing

507
00:29:09,000 --> 00:29:12,760
Speaker 2: up your cells and creating inflammation some of those cells

508
00:29:12,400 --> 00:29:15,440
Speaker 2: it's messing up, it's also messing with their DNA too,

509
00:29:15,920 --> 00:29:21,760
Speaker 2: And when cells with broken basically DNA or altered DNA

510
00:29:22,160 --> 00:29:25,280
Speaker 2: start dividing and creating new cells, they pass along that

511
00:29:25,400 --> 00:29:29,880
Speaker 2: altered DNA. And if the DNA the genes that are altered, say,

512
00:29:29,920 --> 00:29:33,000
Speaker 2: are like tumor suppressing genes, all of a sudden, they're

513
00:29:33,000 --> 00:29:36,040
Speaker 2: not going to stop dividing. They're going to keep going

514
00:29:36,080 --> 00:29:38,080
Speaker 2: and going, and now you have a tumor. So it's

515
00:29:38,160 --> 00:29:39,760
Speaker 2: kind of like a one to two punch just from

516
00:29:39,760 --> 00:29:40,600
Speaker 2: cigarette smoke.

517
00:29:41,240 --> 00:29:44,600
Speaker 1: Yeah. Well, I mean, like we said, the inflammation is

518
00:29:44,640 --> 00:29:48,160
Speaker 1: going to increase the blood flow, increase that cell division rate,

519
00:29:48,240 --> 00:29:51,080
Speaker 1: so it's just like this sort of cycle spinning in

520
00:29:51,160 --> 00:29:51,680
Speaker 1: on itself.

521
00:29:51,880 --> 00:29:53,960
Speaker 2: Yeah, and I think the inflammation is kind of like

522
00:29:54,800 --> 00:29:58,320
Speaker 2: I think COPD is like the inflammation without the tumor part,

523
00:29:58,400 --> 00:30:01,040
Speaker 2: and lung cancer is like the whole package. That's my

524
00:30:01,160 --> 00:30:01,800
Speaker 2: take on it.

525
00:30:02,160 --> 00:30:05,680
Speaker 1: Yeah. So we mentioned earlier that not all cancers are

526
00:30:05,720 --> 00:30:08,120
Speaker 1: due to inflammation, but one we can definitely sort of

527
00:30:08,160 --> 00:30:12,680
Speaker 1: look at now is colon cancer. If you have Crohn's disease.

528
00:30:12,800 --> 00:30:15,360
Speaker 1: If you have ulcer of colitis, then you are way

529
00:30:15,400 --> 00:30:19,680
Speaker 1: more likely to develop colon cancer. And like I said earlier, tho,

530
00:30:20,120 --> 00:30:23,080
Speaker 1: the word inflammatory is in the name there. It's an

531
00:30:23,080 --> 00:30:27,440
Speaker 1: inflammatory bowel disease because you're once again your immune system

532
00:30:27,920 --> 00:30:31,280
Speaker 1: is making a mistake and it's attacking those great healthy

533
00:30:31,320 --> 00:30:34,360
Speaker 1: gut microbes that are keeping your gut nice and balanced,

534
00:30:34,760 --> 00:30:37,400
Speaker 1: and that is going to cause that inflammation just to

535
00:30:37,480 --> 00:30:40,400
Speaker 1: stick around forever. Basically can lead to ulcers as well,

536
00:30:41,040 --> 00:30:43,960
Speaker 1: and that again just sort of like the lung cancer

537
00:30:45,000 --> 00:30:47,800
Speaker 1: that can damage the DNA in the same way we

538
00:30:47,800 --> 00:30:50,560
Speaker 1: were talking about with lung cancer and all of a

539
00:30:50,560 --> 00:30:51,520
Speaker 1: sudden you have a tumor.

540
00:30:51,840 --> 00:30:55,800
Speaker 2: Yep, And the same process can also happen with chronic

541
00:30:55,800 --> 00:30:59,520
Speaker 2: infections like tuberculosis and HPV, which is like I've always

542
00:30:59,560 --> 00:31:04,080
Speaker 2: been like, how a virus caused cancer. That's how it creates.

543
00:31:04,080 --> 00:31:09,400
Speaker 2: It brings chronic inflammation to the site of the cancer.

544
00:31:09,560 --> 00:31:11,240
Speaker 1: All Right, I feel like now we should take the break.

545
00:31:11,440 --> 00:31:13,200
Speaker 2: Yeah, I think you're right. I can find that too.

546
00:31:13,240 --> 00:31:15,880
Speaker 1: We'll be right back and talk about sort of a

547
00:31:16,000 --> 00:31:18,760
Speaker 1: surprising thing and how depression relates to this.

548
00:31:46,520 --> 00:31:49,479
Speaker 2: All right, Chuck, So you mentioned depression before the break,

549
00:31:49,560 --> 00:31:52,920
Speaker 2: and that is I mean, at least as surprising as

550
00:31:52,960 --> 00:32:00,720
Speaker 2: Alzheimer's potentially being caused by chronic inflammation. Agreed, There's a again,

551
00:32:00,760 --> 00:32:03,360
Speaker 2: a few interpretations of this that we'll get to. But

552
00:32:03,760 --> 00:32:06,400
Speaker 2: the reason that they're like, I really think not for

553
00:32:06,480 --> 00:32:08,960
Speaker 2: all of them, but that there's a significant portion of

554
00:32:09,000 --> 00:32:13,120
Speaker 2: people with depression who are suffering depression not because of

555
00:32:13,160 --> 00:32:17,680
Speaker 2: a neurochemical imbalance but because of inflammation. And the reason

556
00:32:17,720 --> 00:32:20,520
Speaker 2: that that group has kind of emerged as a possibility

557
00:32:20,920 --> 00:32:23,959
Speaker 2: is because there's always been about thirty percent of people

558
00:32:24,240 --> 00:32:30,160
Speaker 2: who've never really responded to SSRIs and other treatments for depression,

559
00:32:30,200 --> 00:32:33,880
Speaker 2: other chemical treatments for depression that target neurotransmitters and try

560
00:32:33,920 --> 00:32:38,000
Speaker 2: to restore balance in the brain. And if your chemicals

561
00:32:38,000 --> 00:32:40,280
Speaker 2: aren't out of balance, you're not going to respond to

562
00:32:40,320 --> 00:32:45,600
Speaker 2: those if the problem is that you have neuroinflammation. And

563
00:32:45,880 --> 00:32:48,520
Speaker 2: they're saying for at least about a third of people,

564
00:32:48,640 --> 00:32:51,360
Speaker 2: it's possible that it's neuroinflammation and causing depression.

565
00:32:51,960 --> 00:32:54,920
Speaker 1: Yeah, and you know, there's a lot of things to

566
00:32:54,960 --> 00:32:58,520
Speaker 1: go over here. One is, if you have an autoimmune

567
00:32:58,520 --> 00:33:03,400
Speaker 1: disorder and it's an autoimmune disorder, that causes chronic inflammation,

568
00:33:04,240 --> 00:33:07,320
Speaker 1: then you are way more likely to be diagnosed with depression.

569
00:33:07,760 --> 00:33:11,360
Speaker 1: That is again, that's sort of a correlation I guess

570
00:33:11,360 --> 00:33:13,960
Speaker 1: that we can look at right now. They have done

571
00:33:13,960 --> 00:33:17,320
Speaker 1: autopsies on people who have died by suicide that have

572
00:33:17,400 --> 00:33:22,480
Speaker 1: also shown elevated levels of neuroinflammation. And then this study

573
00:33:22,640 --> 00:33:26,760
Speaker 1: that our ol buddy Dave Rus found in cancer patients.

574
00:33:26,800 --> 00:33:30,520
Speaker 1: Forty different cancer patients that had no history of depression

575
00:33:30,600 --> 00:33:34,560
Speaker 1: at all in their life were treated with a chemical,

576
00:33:35,320 --> 00:33:40,200
Speaker 1: an inflammatory cytokine known as interferon alpha, which your body

577
00:33:40,560 --> 00:33:45,400
Speaker 1: naturally releases all the time as part of our inflammatory response,

578
00:33:45,440 --> 00:33:48,240
Speaker 1: part of our immune system. And when these patients said

579
00:33:48,280 --> 00:33:51,600
Speaker 1: no history of depression, these cancer patients were injected with

580
00:33:51,720 --> 00:33:55,760
Speaker 1: interfer on alpha, their moods were altered, and many of

581
00:33:55,760 --> 00:33:58,200
Speaker 1: them said, you know, I feel depressed.

582
00:33:58,400 --> 00:34:01,240
Speaker 2: Yeah, which is I mean, all of that put together especially,

583
00:34:01,320 --> 00:34:06,520
Speaker 2: is pretty strong evidence for that theory. The question or

584
00:34:06,560 --> 00:34:09,200
Speaker 2: the answer to the question like how is this happening

585
00:34:09,280 --> 00:34:12,279
Speaker 2: or how is this creating depression? Again, there's a couple

586
00:34:12,280 --> 00:34:15,759
Speaker 2: of theories. One is straightforward as well. The inflammation is

587
00:34:15,800 --> 00:34:18,920
Speaker 2: messing with some of your pathways that produce things like

588
00:34:19,400 --> 00:34:26,440
Speaker 2: happiness and pleasure and your ability to relax. That's pretty straightforward.

589
00:34:26,719 --> 00:34:29,879
Speaker 2: There's another kind of more roundabout one that says that

590
00:34:29,960 --> 00:34:35,239
Speaker 2: this chronic inflammation is triggering a sweeter cluster of behaviors

591
00:34:35,280 --> 00:34:42,799
Speaker 2: called sickness behaviors, where you're fatigued, you're anhdonic, which means

592
00:34:42,800 --> 00:34:46,719
Speaker 2: you can't experience pleasure, you don't eat very much, you

593
00:34:46,760 --> 00:34:50,080
Speaker 2: don't really feel like interacting with other people, and that

594
00:34:50,080 --> 00:34:53,160
Speaker 2: that is actually like that group of sickness behaviors kind

595
00:34:53,160 --> 00:34:56,359
Speaker 2: of evolved in humans to get us to just sit

596
00:34:56,400 --> 00:34:59,120
Speaker 2: down and relax and rest when we were sick, so

597
00:34:59,160 --> 00:35:02,399
Speaker 2: that our immune system could like take over and take

598
00:35:02,440 --> 00:35:06,040
Speaker 2: care of it without having to shuffle some of that

599
00:35:06,120 --> 00:35:08,719
Speaker 2: metabolism for us going for a jog or something, right,

600
00:35:09,040 --> 00:35:14,560
Speaker 2: And that the brain is is not really differentiating between

601
00:35:14,560 --> 00:35:16,560
Speaker 2: the two because you're not sick, but you still have

602
00:35:16,600 --> 00:35:19,319
Speaker 2: the sickness behaviors, and that they're saying that is that

603
00:35:19,440 --> 00:35:21,160
Speaker 2: specific variety of depression.

604
00:35:21,640 --> 00:35:23,800
Speaker 1: I really, you know how much we love when something

605
00:35:23,840 --> 00:35:29,239
Speaker 1: goes back to evolutionary advantage, right, And it's just so

606
00:35:29,320 --> 00:35:32,880
Speaker 1: cool to think about tuktok tuk tuk no feel good, right,

607
00:35:33,120 --> 00:35:36,360
Speaker 1: Tuck Tuck go and sit by himself and let and

608
00:35:36,440 --> 00:35:39,600
Speaker 1: let and let body fix itself. Sure, Tuck Tuck no

609
00:35:39,760 --> 00:35:47,160
Speaker 1: want to play rock ball, Tuck Tuck need time alone.

610
00:35:47,320 --> 00:35:50,279
Speaker 2: Tuk tuk need to dial up out of office email.

611
00:35:50,719 --> 00:35:54,279
Speaker 1: Yeah, so people say tuktuk depressed and tuk tuk say

612
00:35:54,360 --> 00:35:56,160
Speaker 1: no natural body response.

613
00:35:57,280 --> 00:36:00,800
Speaker 2: Right, but again, if you can attribute it to a sickness,

614
00:36:01,680 --> 00:36:03,280
Speaker 2: it might be confused for depression.

615
00:36:03,640 --> 00:36:06,640
Speaker 1: Yeah. I think that's really super fascinating.

616
00:36:06,200 --> 00:36:10,680
Speaker 2: Totally, and that actually the evolution thing really kind of

617
00:36:10,800 --> 00:36:17,320
Speaker 2: underscores the explanation for a whole other group of diseases

618
00:36:17,360 --> 00:36:20,560
Speaker 2: that are linked to chronic inflammation, things like heart disease,

619
00:36:20,920 --> 00:36:26,759
Speaker 2: type two diabetes, some types of cancer, kidney failure, a

620
00:36:26,800 --> 00:36:29,680
Speaker 2: lot of stuff that a lot of diseases I should

621
00:36:29,680 --> 00:36:31,640
Speaker 2: say that kill a lot of people and make even

622
00:36:31,800 --> 00:36:36,719
Speaker 2: more people suffer that are probably not very old. They

623
00:36:36,760 --> 00:36:39,520
Speaker 2: probably don't go very far back in our evolutionary history

624
00:36:39,719 --> 00:36:43,719
Speaker 2: because they're probably the result of just kind of the

625
00:36:43,760 --> 00:36:47,840
Speaker 2: trappings of industrialization. The food we eat, the environmental toxins

626
00:36:47,880 --> 00:36:51,160
Speaker 2: were exposed to, the work hours that we set for ourselves,

627
00:36:51,200 --> 00:36:54,160
Speaker 2: the stress that can kind of come from living in

628
00:36:54,200 --> 00:36:58,480
Speaker 2: the modern world, and that all of these new things

629
00:36:58,520 --> 00:37:02,880
Speaker 2: that we humans expose ourselves too don't really jibe with

630
00:37:03,160 --> 00:37:06,359
Speaker 2: the way that we evolve to live. And so we're

631
00:37:06,360 --> 00:37:09,440
Speaker 2: in this really rough transition period right now where our

632
00:37:09,440 --> 00:37:12,320
Speaker 2: bodies are like this is all wrong and this is

633
00:37:12,360 --> 00:37:14,960
Speaker 2: all disease, and we're like, no, this is the food

634
00:37:15,000 --> 00:37:19,160
Speaker 2: we eat now. And that evolutionary mismatch is One group

635
00:37:19,200 --> 00:37:22,040
Speaker 2: of authors of a really influential paper put it as

636
00:37:22,280 --> 00:37:26,040
Speaker 2: what causes that chronic inflammation and hence those diseases.

637
00:37:26,560 --> 00:37:28,360
Speaker 1: Yeah, I mean it makes sense when you think about it.

638
00:37:28,400 --> 00:37:31,480
Speaker 1: We have the same brain that tuk Took had when

639
00:37:31,480 --> 00:37:37,040
Speaker 1: they found uncontacted tribes, and uncontacted is a It doesn't

640
00:37:37,080 --> 00:37:40,440
Speaker 1: mean literally no one has ever talked to them. It

641
00:37:40,480 --> 00:37:42,120
Speaker 1: just means they're generally left alone.

642
00:37:42,520 --> 00:37:44,480
Speaker 2: They want to be left alone, so we leave them alone.

643
00:37:44,719 --> 00:37:47,840
Speaker 1: Yeah, but still we don't leave them alone because sometimes

644
00:37:47,840 --> 00:37:50,880
Speaker 1: anthropologists will go in there and spend time with them.

645
00:37:51,400 --> 00:37:54,719
Speaker 1: But what they're not finding in those tribes is type

646
00:37:54,760 --> 00:37:58,680
Speaker 1: two diabetes, and they're not finding ibs, and they're not

647
00:37:58,800 --> 00:38:02,600
Speaker 1: finding these like very sort of not to name check

648
00:38:02,920 --> 00:38:06,480
Speaker 1: another Chevy Chase movie, but they're not finding these modern problems.

649
00:38:07,239 --> 00:38:10,480
Speaker 2: Right, And so some people are like, well, hunter gatherers

650
00:38:10,520 --> 00:38:13,799
Speaker 2: typically don't have the same lifespans that we do, so

651
00:38:13,880 --> 00:38:16,760
Speaker 2: it's probably aging. It's that free radical theory of aging.

652
00:38:16,800 --> 00:38:19,920
Speaker 2: That's what causes inflammation. It's not the food we eat

653
00:38:20,000 --> 00:38:22,719
Speaker 2: or anything. It's like, no, it's definitely the food that

654
00:38:22,760 --> 00:38:25,799
Speaker 2: we eat. It's definitely the environmental toxins. It's definitely the

655
00:38:25,880 --> 00:38:30,280
Speaker 2: stress because if you study all those things, they cause

656
00:38:30,480 --> 00:38:33,640
Speaker 2: that inflammation. And if you look at like hunter gatherers

657
00:38:33,719 --> 00:38:37,399
Speaker 2: or uncontacted tribes, like they're not eating that stuff, they

658
00:38:37,400 --> 00:38:40,320
Speaker 2: don't have that kind of inflammation, they don't have those diseases.

659
00:38:40,360 --> 00:38:44,319
Speaker 2: It's not to do with the lower life expectancy. It's

660
00:38:44,320 --> 00:38:46,480
Speaker 2: to do with the fact that they don't expose themselves

661
00:38:46,680 --> 00:38:50,120
Speaker 2: to the things that we expose ourselves. So industrialization has

662
00:38:50,200 --> 00:38:54,960
Speaker 2: kind of led to this brand new group of diseases,

663
00:38:55,080 --> 00:38:59,759
Speaker 2: chronic diseases that all seem to be stemming from chronic inflammation.

664
00:39:00,440 --> 00:39:03,000
Speaker 1: That's right. I wonder what happens when they give one

665
00:39:03,000 --> 00:39:04,400
Speaker 1: of those hunter gatherers a cheeto.

666
00:39:05,000 --> 00:39:07,160
Speaker 2: Oh dude, they go fuck wild.

667
00:39:07,480 --> 00:39:09,279
Speaker 1: Yeah, oh boy, No.

668
00:39:09,280 --> 00:39:10,840
Speaker 2: One can turn down a cheetoh. And once you have

669
00:39:10,880 --> 00:39:13,120
Speaker 2: a Cheetoh, You're like, give me ten more Cheetos and

670
00:39:13,160 --> 00:39:15,360
Speaker 2: then give me the bag. And now I'm moving to

671
00:39:15,400 --> 00:39:17,719
Speaker 2: Portland so I can have easy access to.

672
00:39:17,760 --> 00:39:21,640
Speaker 1: Cheetos right in street tacos.

673
00:39:21,920 --> 00:39:23,000
Speaker 2: Yeah. Good.

674
00:39:23,040 --> 00:39:25,440
Speaker 1: By the way, I mentioned, I apologize for Chevy Chase

675
00:39:25,480 --> 00:39:29,160
Speaker 1: because you're a well known hater of Chevy Chase.

676
00:39:29,680 --> 00:39:33,920
Speaker 2: Yeah, it's okay. I've got little bloody half crescent moons

677
00:39:34,040 --> 00:39:36,719
Speaker 2: in my palm from my fingernails, okay, because I was

678
00:39:36,719 --> 00:39:38,520
Speaker 2: holding my piece, But I appreciate that.

679
00:39:38,600 --> 00:39:40,359
Speaker 1: I just wanted to explain that to newer listeners. They

680
00:39:40,360 --> 00:39:42,319
Speaker 1: were like, why are you apologizing for Chevy Chase. Guess

681
00:39:42,680 --> 00:39:44,319
Speaker 1: Josh is on record is not being a big fan.

682
00:39:44,600 --> 00:39:46,759
Speaker 2: Well, I was raised to despise Chevy, right.

683
00:39:46,760 --> 00:39:48,480
Speaker 1: You're dad didn't like him, right, Yeah, And.

684
00:39:48,360 --> 00:39:50,720
Speaker 2: He literally raised me to hate Chevy Chase.

685
00:39:50,920 --> 00:39:52,839
Speaker 1: That's really funny. What was his beef again? Was it

686
00:39:52,880 --> 00:39:55,080
Speaker 1: just he thought he was a which is what he

687
00:39:55,280 --> 00:39:59,040
Speaker 1: was was a cocky sort of sob yeah jerk.

688
00:39:59,440 --> 00:40:03,319
Speaker 2: I'm sure he said SOB two probably so yeah. So yeah,

689
00:40:03,520 --> 00:40:06,080
Speaker 2: that was it. And my dad saw right through him, apparently,

690
00:40:06,120 --> 00:40:08,280
Speaker 2: because even at a time when Chevy Chase was beloved

691
00:40:08,320 --> 00:40:12,480
Speaker 2: and could star in like pretty big movies. My dad

692
00:40:12,560 --> 00:40:15,120
Speaker 2: was still like, Nope, that guy, he's not a good guy.

693
00:40:16,080 --> 00:40:18,120
Speaker 1: You know what is not bad, believe it or not,

694
00:40:18,880 --> 00:40:20,920
Speaker 1: is that new Fletch movie with John Ham.

695
00:40:21,800 --> 00:40:24,760
Speaker 2: I can imagine. So I could see it.

696
00:40:24,760 --> 00:40:27,680
Speaker 1: It was pretty good. Yeah, it was very under the radar.

697
00:40:28,680 --> 00:40:30,680
Speaker 2: Yeah, I noticed. I was like, when did that come out?

698
00:40:30,680 --> 00:40:33,560
Speaker 2: It just kind of showed up in Amazon Prime Movies.

699
00:40:33,560 --> 00:40:36,760
Speaker 2: Will think You'll like, I don't know about that Amazon Prime.

700
00:40:37,000 --> 00:40:40,319
Speaker 1: I think it's one of these that the studio kind

701
00:40:40,320 --> 00:40:42,920
Speaker 1: of just bailed on for some reason and didn't do

702
00:40:42,960 --> 00:40:45,160
Speaker 1: any marketing, which I don't get because John Ham's a,

703
00:40:45,680 --> 00:40:47,640
Speaker 1: you know, a big name, and Fletch is a big

704
00:40:47,719 --> 00:40:48,800
Speaker 1: name and it was a good movie.

705
00:40:49,080 --> 00:40:50,759
Speaker 2: Yeah, I don't understand it either.

706
00:40:50,840 --> 00:40:53,879
Speaker 1: It was very fletchy. All right, So let's talk about

707
00:40:53,920 --> 00:40:57,799
Speaker 1: some of these you talked about industrialization in the world

708
00:40:57,800 --> 00:41:00,720
Speaker 1: that we live in and these risk factors in our environment.

709
00:41:02,400 --> 00:41:04,360
Speaker 1: One is, you know, you don't have to be a

710
00:41:04,400 --> 00:41:08,439
Speaker 1: smoker to affect your lungs because you're walking around every

711
00:41:08,520 --> 00:41:13,279
Speaker 1: day as a human on modern earth, breathing airborne pollutants

712
00:41:13,719 --> 00:41:15,840
Speaker 1: that are doing some of the same things that smoking does.

713
00:41:15,880 --> 00:41:20,879
Speaker 1: On a lower level, you are eating microplastics. You are

714
00:41:21,120 --> 00:41:24,359
Speaker 1: if you're using the wrong soaps and shampoos. You can

715
00:41:24,400 --> 00:41:30,080
Speaker 1: have some nasty chemicals like the lights, slates, thelates, thollates.

716
00:41:31,360 --> 00:41:34,600
Speaker 1: Let I say, I said they lights to begin with.

717
00:41:35,080 --> 00:41:37,719
Speaker 2: Yeah, I mean it's all very melodic. All of them

718
00:41:37,719 --> 00:41:38,160
Speaker 2: are fine.

719
00:41:38,600 --> 00:41:40,320
Speaker 1: Well, when you start a word with p H, T

720
00:41:40,600 --> 00:41:42,520
Speaker 1: H anyone.

721
00:41:42,760 --> 00:41:44,680
Speaker 2: You're just being a jerk at that point.

722
00:41:45,200 --> 00:41:47,960
Speaker 1: But all of these things are just in our body

723
00:41:48,000 --> 00:41:51,360
Speaker 1: from walking around in the world unless you live like

724
00:41:51,400 --> 00:41:53,439
Speaker 1: a really clean lifestyle, which is you know, a great

725
00:41:53,440 --> 00:41:57,080
Speaker 1: thing to aspire to, and you're still like breathing air

726
00:41:57,360 --> 00:41:58,200
Speaker 1: exactly right.

727
00:41:58,440 --> 00:42:00,560
Speaker 2: You just you can't get away from it. And like

728
00:42:00,600 --> 00:42:04,719
Speaker 2: they're finding more and more, like microplastics are everywhere. I

729
00:42:04,719 --> 00:42:09,879
Speaker 2: can't remember what they're called forever, chemicals like teflon, they're everywhere.

730
00:42:09,920 --> 00:42:12,719
Speaker 2: It's just everywhere. This to me, if I'm going to

731
00:42:12,760 --> 00:42:15,480
Speaker 2: make another bet in this episode, this is the one

732
00:42:15,520 --> 00:42:22,920
Speaker 2: that's responsible for the most chronic disease. Microplastics, chemicals, industrial toxins,

733
00:42:23,640 --> 00:42:26,279
Speaker 2: air pollution. I think it's going to plant, it's going

734
00:42:26,320 --> 00:42:28,120
Speaker 2: to pan out to be plastics. We're going to find

735
00:42:28,160 --> 00:42:32,320
Speaker 2: the smoking gun because get this chuck. Industrialization has produced

736
00:42:32,360 --> 00:42:35,799
Speaker 2: one hundred and fifty thousand chemicals so far, and we're

737
00:42:35,800 --> 00:42:40,080
Speaker 2: adding two thousand new chemicals each year to our toolbox

738
00:42:40,800 --> 00:42:45,600
Speaker 2: to produce everything from food to paint. And the FDA

739
00:42:45,680 --> 00:42:48,040
Speaker 2: has a mandate to test these things before they approve them,

740
00:42:48,239 --> 00:42:51,200
Speaker 2: and it just isn't happening. I've read it would take

741
00:42:51,280 --> 00:42:54,440
Speaker 2: centuries for the FDA to test to catch up, and

742
00:42:54,480 --> 00:42:56,560
Speaker 2: they're just not ever going to. So these chemicals just

743
00:42:56,600 --> 00:42:58,920
Speaker 2: make it out and no one has any idea, especially

744
00:42:58,920 --> 00:43:01,640
Speaker 2: at first, whether they're harmful or not. We just kind

745
00:43:01,640 --> 00:43:02,799
Speaker 2: of find out the hard way.

746
00:43:03,120 --> 00:43:08,240
Speaker 1: Yeah, the food we eat obviously, you know, fried food,

747
00:43:08,960 --> 00:43:16,920
Speaker 1: sugary sodas, refined sugars, refined carbohydrates, trans fats, meat secured

748
00:43:16,920 --> 00:43:23,400
Speaker 1: with nitrates, booze, some people gluten, some people dairy. This

749
00:43:23,560 --> 00:43:26,319
Speaker 1: you know, this is going to create inflammation. That's called

750
00:43:26,320 --> 00:43:30,920
Speaker 1: an inflammatory diet. If you want to avoid that stuff,

751
00:43:31,400 --> 00:43:33,880
Speaker 1: then you know, the Mediterranean diet is a great place

752
00:43:34,000 --> 00:43:36,839
Speaker 1: to live. I was about to say start, but kind

753
00:43:36,840 --> 00:43:41,920
Speaker 1: of start and stay. Olive oil, lentils, tomatoes, leafy greens,

754
00:43:42,480 --> 00:43:50,320
Speaker 1: fatty fish, cigarettes for cigarettes, blueberries, strawberries, cherries, apples, almonds, walnuts,

755
00:43:50,320 --> 00:43:52,279
Speaker 1: those things are anti.

756
00:43:52,560 --> 00:43:54,640
Speaker 2: What you're naming all the foods.

757
00:43:55,200 --> 00:43:56,920
Speaker 1: That's not all the foods, that's all the good foods.

758
00:43:56,960 --> 00:43:57,560
Speaker 2: It's true.

759
00:43:57,719 --> 00:43:59,480
Speaker 1: You didn't hear me say twinkie and fried chicken.

760
00:44:00,000 --> 00:44:00,680
Speaker 2: Oh, it's true.

761
00:44:01,920 --> 00:44:05,399
Speaker 1: Just avoid those refined foods. Eat real foods. But those

762
00:44:05,440 --> 00:44:09,319
Speaker 1: foods that I listed out are literally anti inflammatory. So

763
00:44:09,360 --> 00:44:11,360
Speaker 1: they're not only just good for your body in general

764
00:44:11,400 --> 00:44:12,799
Speaker 1: and good for your heart and stuff like that, but

765
00:44:13,160 --> 00:44:14,920
Speaker 1: they have anti inflammatory effects.

766
00:44:14,960 --> 00:44:18,799
Speaker 2: Pretty neat and the opposite of the Mediterranean diet, that

767
00:44:18,880 --> 00:44:21,680
Speaker 2: Western diet, another name for it is the standard American

768
00:44:21,760 --> 00:44:25,000
Speaker 2: diet or SAD. And one other thing about it is

769
00:44:25,040 --> 00:44:27,920
Speaker 2: not only plentiful and things like fried foods and sugar,

770
00:44:28,160 --> 00:44:30,600
Speaker 2: it's also really low in fiber, which is a huge

771
00:44:30,600 --> 00:44:32,799
Speaker 2: problem too. And a lot of those foods that you

772
00:44:32,920 --> 00:44:35,759
Speaker 2: just listed off are very high in dietary fiber, which

773
00:44:35,800 --> 00:44:37,719
Speaker 2: is something that if you wanted to figure out where

774
00:44:37,760 --> 00:44:40,600
Speaker 2: to start, increase fiber in your diet and it will

775
00:44:40,600 --> 00:44:41,440
Speaker 2: help a lot.

776
00:44:41,680 --> 00:44:44,759
Speaker 1: Yeah, big time. Me with my gut issues, I've been

777
00:44:45,320 --> 00:44:47,560
Speaker 1: I've been trying to eat as much fiber as possible.

778
00:44:47,680 --> 00:44:50,480
Speaker 2: Good for you, man. The problem is is I hope

779
00:44:50,480 --> 00:44:51,880
Speaker 2: you're rich, and I hope you have a lot of

780
00:44:51,920 --> 00:44:56,360
Speaker 2: time to cook, because it's really tough to avoid ultra

781
00:44:56,480 --> 00:45:00,600
Speaker 2: processed foods otherwise. And that's really sad. That's a sad

782
00:45:00,640 --> 00:45:04,279
Speaker 2: state of affairs. Yeah, but that's kind of how it

783
00:45:04,360 --> 00:45:04,959
Speaker 2: is right now.

784
00:45:06,600 --> 00:45:07,000
Speaker 1: Agreed.

785
00:45:07,840 --> 00:45:11,680
Speaker 2: So another one is sedentary lifestyle physical activity, right, Like,

786
00:45:12,120 --> 00:45:14,319
Speaker 2: I didn't know this, but when you exercise, when your

787
00:45:14,360 --> 00:45:19,360
Speaker 2: skeletal muscles contract, they actually release anti inflammatory proteins that

788
00:45:19,440 --> 00:45:21,319
Speaker 2: go throughout your entire body. Did you know that?

789
00:45:21,800 --> 00:45:24,680
Speaker 1: I didn't know that. But like, full stop, that's all

790
00:45:24,719 --> 00:45:25,360
Speaker 1: you need to say.

791
00:45:25,680 --> 00:45:27,600
Speaker 2: Yeah, because well I'm going to say some more.

792
00:45:27,840 --> 00:45:28,120
Speaker 1: Yeah.

793
00:45:28,239 --> 00:45:32,040
Speaker 2: The point is it's not sitting around that causes inflammation.

794
00:45:32,600 --> 00:45:36,799
Speaker 2: It's not exercising that allows inflammation to go on unchecked.

795
00:45:36,960 --> 00:45:39,719
Speaker 2: That's the kind of the explanation of that one. And

796
00:45:39,760 --> 00:45:42,400
Speaker 2: there's a lot of people who are not physically active.

797
00:45:42,400 --> 00:45:45,200
Speaker 2: Fifty percent of American adults aren't physically active. They get

798
00:45:45,280 --> 00:45:48,320
Speaker 2: less than one hundred and fifty minutes of moderate aerobic

799
00:45:48,400 --> 00:45:50,000
Speaker 2: activity each week.

800
00:45:50,680 --> 00:45:53,719
Speaker 1: Yeah, so like if you're I mean, I don't know

801
00:45:53,760 --> 00:45:56,239
Speaker 1: a lot of people that make a case against exercising,

802
00:45:56,800 --> 00:45:59,319
Speaker 1: but I have heard people say stuff like Oh, you know,

803
00:45:59,360 --> 00:46:01,080
Speaker 1: you go out and you you walk for forty five

804
00:46:01,080 --> 00:46:03,960
Speaker 1: minutes and all that that just burns up. Like they

805
00:46:04,000 --> 00:46:06,600
Speaker 1: just look at like how many calories that burns And

806
00:46:06,760 --> 00:46:09,560
Speaker 1: you know it may not be a ton of literal calories.

807
00:46:09,960 --> 00:46:13,400
Speaker 1: But there's so many other benefits to exercising totally beyond

808
00:46:13,400 --> 00:46:14,280
Speaker 1: just burning calories.

809
00:46:14,400 --> 00:46:16,440
Speaker 2: Yeah. And I mean we've talked about it before, like

810
00:46:16,800 --> 00:46:19,319
Speaker 2: exercise is not for weight loss, if that's what you're

811
00:46:19,320 --> 00:46:22,880
Speaker 2: trying to do. Exercises for things like anti inflammatory release,

812
00:46:23,000 --> 00:46:26,400
Speaker 2: your mental health. Yeah, all the other benefits you are

813
00:46:26,440 --> 00:46:28,240
Speaker 2: talking about anything basically butt.

814
00:46:28,080 --> 00:46:30,560
Speaker 1: Weight loss, yeah, plus plus a little bit of calorie

815
00:46:30,600 --> 00:46:32,120
Speaker 1: production or calorie burning.

816
00:46:32,400 --> 00:46:36,920
Speaker 2: But speaking of weight loss, another problem of a sedentary

817
00:46:36,960 --> 00:46:42,440
Speaker 2: lifestyle is excess weight and at a posts tissue, a

818
00:46:42,560 --> 00:46:46,239
Speaker 2: visceral adipost tissue, which you would call like belly fat,

819
00:46:47,160 --> 00:46:49,799
Speaker 2: your body says, okay, here's it. This is a normal level,

820
00:46:49,840 --> 00:46:52,640
Speaker 2: and if you exceed the normal level, your body takes

821
00:46:52,680 --> 00:46:56,040
Speaker 2: it as problematic and that causes inflammation in and of itself.

822
00:46:56,800 --> 00:46:58,680
Speaker 1: I know, man, that belly fat is no good.

823
00:46:59,000 --> 00:46:59,640
Speaker 2: No, it's true.

824
00:47:00,080 --> 00:47:02,680
Speaker 1: Any other kind of fat on your body, yeah, uh,

825
00:47:03,440 --> 00:47:05,280
Speaker 1: And there's something I'm working on I've lost fifteen pounds.

826
00:47:05,320 --> 00:47:09,200
Speaker 2: By the way, Hey, congratulations man, wow wee wait, yeah.

827
00:47:08,840 --> 00:47:10,840
Speaker 1: It's it's just a start, but I feel like, I

828
00:47:10,880 --> 00:47:14,040
Speaker 1: don't know, this feels more real than before.

829
00:47:14,320 --> 00:47:15,839
Speaker 2: Are you taking a long view of it?

830
00:47:16,800 --> 00:47:19,359
Speaker 1: I'm taking a I don't want to die view of it,

831
00:47:19,400 --> 00:47:21,799
Speaker 1: and I want to I want to look better at you.

832
00:47:22,120 --> 00:47:24,719
Speaker 2: Yeah, that's great, man. One thing I've been trying to

833
00:47:24,760 --> 00:47:26,360
Speaker 2: do the same thing, and one thing I've come up

834
00:47:26,400 --> 00:47:30,040
Speaker 2: with is anytime I'm like frustrated or impatient or I

835
00:47:30,200 --> 00:47:33,040
Speaker 2: just am not where I want to be, I've learned

836
00:47:33,040 --> 00:47:34,839
Speaker 2: to just tell myself, like, this is where I am

837
00:47:34,920 --> 00:47:37,439
Speaker 2: right now. I'm not always going to be here. I'm

838
00:47:37,440 --> 00:47:39,840
Speaker 2: going to have setbacks, I'm going to have advances, but

839
00:47:41,000 --> 00:47:44,000
Speaker 2: this is just what I am right now. And that's fine.

840
00:47:44,239 --> 00:47:47,840
Speaker 1: Man. That's a very healthy way to be.

841
00:47:48,000 --> 00:47:49,640
Speaker 2: It's helped me a lot, like a lot.

842
00:47:49,920 --> 00:47:50,359
Speaker 1: That's great.

843
00:47:50,400 --> 00:47:53,560
Speaker 2: It's helped get me through some real like problematic valleys.

844
00:47:53,920 --> 00:47:55,200
Speaker 1: Good good advice too.

845
00:47:55,440 --> 00:47:55,720
Speaker 2: Thanks.

846
00:47:55,760 --> 00:47:59,279
Speaker 1: We're just doling it out today. We totally are lose weight,

847
00:48:00,000 --> 00:48:02,680
Speaker 1: support yourself, quit smoking. Don't say that about my friend.

848
00:48:02,800 --> 00:48:03,400
Speaker 1: Quit smoking.

849
00:48:03,480 --> 00:48:04,680
Speaker 2: Yeah that's another one too.

850
00:48:05,880 --> 00:48:10,800
Speaker 1: Stress is a big deal. Obviously, if you are chronically stressed,

851
00:48:11,840 --> 00:48:13,960
Speaker 1: many many bad things will happen, but it is an

852
00:48:14,000 --> 00:48:20,400
Speaker 1: inflammatory trigger. The cortisol levels in your body, you know,

853
00:48:20,520 --> 00:48:24,400
Speaker 1: being sustained like that are really gonna mess with your

854
00:48:24,440 --> 00:48:27,040
Speaker 1: body as a whole, but definitely mess with their ability

855
00:48:27,080 --> 00:48:32,879
Speaker 1: to regulate, regulate inflammation and you know, trauma. They've even

856
00:48:32,920 --> 00:48:36,399
Speaker 1: found that, like childhood trauma much later in life can

857
00:48:36,440 --> 00:48:38,320
Speaker 1: be really tied to inflammatory markers.

858
00:48:38,600 --> 00:48:41,000
Speaker 2: Yeah, like we've we've always been like a well people

859
00:48:41,080 --> 00:48:44,000
Speaker 2: like eat to cope later on from like a childhood

860
00:48:44,000 --> 00:48:48,320
Speaker 2: trauma and more complicated. Yeah, it actually may be more complicated.

861
00:48:48,320 --> 00:48:51,600
Speaker 2: That might maybe that you have, you know, markers that

862
00:48:51,719 --> 00:48:54,839
Speaker 2: set you up to to have excess weight that it's

863
00:48:54,880 --> 00:48:59,360
Speaker 2: really difficult for you to lose because of inflammation because

864
00:48:59,400 --> 00:49:02,640
Speaker 2: you have a genetic code programmed in you from an

865
00:49:02,680 --> 00:49:06,480
Speaker 2: early age epigenetically and epigenetically it can also be passed

866
00:49:06,480 --> 00:49:11,560
Speaker 2: along from mom and dad to kid and set them

867
00:49:11,640 --> 00:49:15,080
Speaker 2: up without any childhood trauma, but their parents had trauma

868
00:49:15,239 --> 00:49:17,760
Speaker 2: that encoded it into their genes that they now passed

869
00:49:17,760 --> 00:49:19,839
Speaker 2: along to their kid who's going to struggle with weight

870
00:49:19,880 --> 00:49:23,279
Speaker 2: all of their life because their parents were neglected when

871
00:49:23,320 --> 00:49:23,879
Speaker 2: they were young.

872
00:49:25,160 --> 00:49:31,319
Speaker 1: Combine that with can your grandfather's diet affect what was

873
00:49:31,320 --> 00:49:33,839
Speaker 1: it affect your weight?

874
00:49:34,000 --> 00:49:37,280
Speaker 2: The name of that one weight or something I don't remember,

875
00:49:37,480 --> 00:49:40,319
Speaker 2: but it was just if you just look up grandfather's diet, which,

876
00:49:40,320 --> 00:49:42,520
Speaker 2: by the way, you should tell everybody at long last.

877
00:49:42,560 --> 00:49:47,160
Speaker 2: I think the soft opening is over soft opening, not

878
00:49:47,680 --> 00:49:52,120
Speaker 2: two words that should go together. But we just updated

879
00:49:52,200 --> 00:49:57,560
Speaker 2: with the help of our great friend Brandon Reid announcing Yeah,

880
00:49:57,719 --> 00:49:59,520
Speaker 2: you are you ready, because if not, we can edit

881
00:49:59,560 --> 00:49:59,839
Speaker 2: it out.

882
00:50:00,120 --> 00:50:01,040
Speaker 1: No, no, no, let's do it.

883
00:50:01,840 --> 00:50:05,239
Speaker 2: What we just unveil the brand new, updated Way to

884
00:50:05,280 --> 00:50:08,440
Speaker 2: Go version of stuff youshould know dot com.

885
00:50:08,719 --> 00:50:10,960
Speaker 1: Yeah, and as in brand new, it's sort of the

886
00:50:10,960 --> 00:50:14,239
Speaker 1: first time we've ever had a real website pretty much. Yeah,

887
00:50:14,360 --> 00:50:16,759
Speaker 1: you're fifteen years in, let's get a website.

888
00:50:16,880 --> 00:50:19,719
Speaker 2: Yeah for sure. So all of the episodes are there,

889
00:50:19,760 --> 00:50:22,200
Speaker 2: all of them, all fifteen hundred plus. You can just

890
00:50:22,320 --> 00:50:24,680
Speaker 2: keep scrolling until your eyes start bleeding.

891
00:50:24,880 --> 00:50:25,920
Speaker 1: The search is much better.

892
00:50:26,120 --> 00:50:28,960
Speaker 2: Yes, you can also search grandfather's diet and it's going

893
00:50:29,000 --> 00:50:33,640
Speaker 2: to bring up that episode. Also, there's like tour dates

894
00:50:34,440 --> 00:50:39,279
Speaker 2: about us. It's real like paired rounds, but it's got

895
00:50:39,320 --> 00:50:40,279
Speaker 2: everything that you need.

896
00:50:40,520 --> 00:50:42,560
Speaker 1: Yeah, we asked for something sort of simple and clean

897
00:50:42,640 --> 00:50:45,080
Speaker 1: and big. Thanks to Brandon, he killed it.

898
00:50:45,239 --> 00:50:47,239
Speaker 2: Huge, thanks to Brandon. Thanks a lot, man.

899
00:50:47,600 --> 00:50:53,480
Speaker 1: It's great speaking of websites and looking at them on

900
00:50:53,480 --> 00:50:57,520
Speaker 1: a screen, like how I did that? I do screens

901
00:50:57,520 --> 00:51:00,840
Speaker 1: can disrupt your sleep. All the artificial in our modern

902
00:51:00,880 --> 00:51:04,240
Speaker 1: worlds disrupts our sleep. Certainly if you have a shift

903
00:51:04,239 --> 00:51:08,400
Speaker 1: work job where you're alternating day and night or just

904
00:51:08,520 --> 00:51:11,279
Speaker 1: completely flipping and working nights only, this is going to

905
00:51:11,320 --> 00:51:15,120
Speaker 1: mess up with the natural circadian rhythm that Took Took

906
00:51:15,760 --> 00:51:18,920
Speaker 1: and our uncontacted friends have, which is it's dark, so

907
00:51:18,960 --> 00:51:21,600
Speaker 1: we sleep, it's light, so we wake up. And this

908
00:51:21,840 --> 00:51:27,480
Speaker 1: all effects and promotes inflammation. They've even done studies where

909
00:51:27,960 --> 00:51:31,760
Speaker 1: just shift work alone is a risk factor for cardiovascular

910
00:51:32,440 --> 00:51:37,360
Speaker 1: cardiovascular disease, type two diabetes, obesity, different kinds of cancer.

911
00:51:37,680 --> 00:51:39,279
Speaker 1: And that's just if you do shift work.

912
00:51:39,560 --> 00:51:42,839
Speaker 2: Yeah, And it's because your circadian rhythm is so intimately

913
00:51:42,920 --> 00:51:45,399
Speaker 2: tied to your immune system that if it gets out

914
00:51:45,440 --> 00:51:48,520
Speaker 2: of whack, your immune system gets out of whack real quick.

915
00:51:49,040 --> 00:51:49,480
Speaker 1: Yeah.

916
00:51:49,760 --> 00:51:52,400
Speaker 2: Aging also, I mean we talked about it earlier. We

917
00:51:52,440 --> 00:51:55,760
Speaker 2: also talked about in the free radicals theory of aging episode.

918
00:51:55,800 --> 00:51:59,560
Speaker 2: But one of the other ways that aging can create

919
00:51:59,680 --> 00:52:04,680
Speaker 2: chronic inflammation is something called immunosinescence, where your immune system

920
00:52:04,800 --> 00:52:09,560
Speaker 2: just stops functioning properly, opens you up to infections more.

921
00:52:09,880 --> 00:52:13,319
Speaker 2: But also your immune system goes haywire a little bit too,

922
00:52:13,400 --> 00:52:17,240
Speaker 2: and your t helper cells start turning on your healthy tissue,

923
00:52:17,440 --> 00:52:20,040
Speaker 2: which can also trigger chronic inflammation.

924
00:52:21,080 --> 00:52:24,239
Speaker 1: Isn't it interesting how much more you think about this

925
00:52:24,280 --> 00:52:27,479
Speaker 1: stuff as you get hold her. Yeah, totally remember thinking

926
00:52:27,480 --> 00:52:29,640
Speaker 1: about any of this stuff when I was in my twenties.

927
00:52:29,800 --> 00:52:32,720
Speaker 2: No, but hopefully we have some like twenties and thirties

928
00:52:32,760 --> 00:52:34,879
Speaker 2: people who are listening right now and are like, oh,

929
00:52:34,920 --> 00:52:37,000
Speaker 2: I'm going to take care of myself earlier than Josh

930
00:52:37,000 --> 00:52:37,840
Speaker 2: and Chuck started it.

931
00:52:37,920 --> 00:52:41,440
Speaker 1: Yeah, you two will age. Yeah, there ain't no stopping it,

932
00:52:41,520 --> 00:52:43,640
Speaker 1: so get ready.

933
00:52:43,960 --> 00:52:46,200
Speaker 2: Yeah. That reminds me of that Simpson's in the House

934
00:52:46,239 --> 00:52:49,960
Speaker 2: of Horrors. Lisa's going through. There's an old lady in

935
00:52:50,000 --> 00:52:56,440
Speaker 2: a rocking chair and she goes, behold the ravages of age.

936
00:52:57,400 --> 00:52:59,120
Speaker 2: I thought that would get a better response.

937
00:52:59,360 --> 00:53:01,520
Speaker 1: Well, was that the punchline?

938
00:53:02,120 --> 00:53:05,520
Speaker 2: Yeah, she was going through like a house of horrors

939
00:53:05,560 --> 00:53:08,360
Speaker 2: and like that, I got you one of the things.

940
00:53:08,080 --> 00:53:10,040
Speaker 1: Was to be like a monster and then the rabbage

941
00:53:10,200 --> 00:53:11,320
Speaker 1: get it. That is the punchline.

942
00:53:11,360 --> 00:53:13,440
Speaker 2: I didn't do a good job of explaining it. No.

943
00:53:13,560 --> 00:53:15,439
Speaker 1: I thought she was going to say they're ravages of age,

944
00:53:15,440 --> 00:53:17,040
Speaker 1: and then she would reveal something or something.

945
00:53:17,080 --> 00:53:20,760
Speaker 2: But she's just sitting in a rocker's she in herself.

946
00:53:20,840 --> 00:53:23,839
Speaker 1: Yeah, I totally get it now, I'm a little slow

947
00:53:23,880 --> 00:53:28,279
Speaker 1: on the uptake today. There is a test for inflammation

948
00:53:28,360 --> 00:53:32,760
Speaker 1: in general, a blood test called HS little HS big CRP.

949
00:53:33,880 --> 00:53:36,040
Speaker 1: It measures and something we've talked about quite a bit

950
00:53:36,040 --> 00:53:39,319
Speaker 1: on the show. See reactive protein. It's produced in the

951
00:53:39,320 --> 00:53:42,440
Speaker 1: liver and if you have a high CRP number, it

952
00:53:42,480 --> 00:53:45,520
Speaker 1: means you probably have a lot of chronic inflammation. It

953
00:53:45,520 --> 00:53:49,000
Speaker 1: doesn't pinpoint exactly what is inflamed, but it's still a

954
00:53:49,080 --> 00:53:50,799
Speaker 1: worthwhile test to have.

955
00:53:51,160 --> 00:53:53,000
Speaker 2: Yeah, no, for sure. And that's one of the things

956
00:53:53,000 --> 00:53:56,640
Speaker 2: that they're trying to crack is there's no reliable biomarkers

957
00:53:56,800 --> 00:54:00,120
Speaker 2: of chronic inflammation. That one's a pretty good one, but

958
00:54:00,160 --> 00:54:02,759
Speaker 2: there's not like a whole whole group that you can

959
00:54:02,800 --> 00:54:04,960
Speaker 2: be like, this is where it's happening, this is why

960
00:54:05,000 --> 00:54:07,320
Speaker 2: it's happening, This is how to fix it just based

961
00:54:07,360 --> 00:54:10,160
Speaker 2: on those those biomarkers. But there are some things you

962
00:54:10,160 --> 00:54:13,279
Speaker 2: can do to keep it from ever happening in the

963
00:54:13,280 --> 00:54:16,040
Speaker 2: first place, or to get to get it to go away.

964
00:54:16,080 --> 00:54:17,600
Speaker 2: I mean, one of the things if you start to

965
00:54:17,600 --> 00:54:21,920
Speaker 2: make some lifestyle changes, like it can turn diseases around,

966
00:54:22,080 --> 00:54:24,800
Speaker 2: like you can come out of pre diabetes, you can,

967
00:54:25,640 --> 00:54:30,279
Speaker 2: you can cure clear up some bowel disorders like it

968
00:54:30,320 --> 00:54:33,759
Speaker 2: can have like a really pronounced effect if you actually exercise,

969
00:54:34,600 --> 00:54:38,000
Speaker 2: if you try to maintain a healthy weight, cut out

970
00:54:38,280 --> 00:54:42,360
Speaker 2: highly processed foods, quit smoking, quit smoking, drink get that

971
00:54:42,400 --> 00:54:46,400
Speaker 2: good sleep yeah, cut down on drinking yeah. And also

972
00:54:46,920 --> 00:54:50,120
Speaker 2: being more social. Apparently this is bad news for the

973
00:54:50,160 --> 00:54:54,040
Speaker 2: introverts like me, because the more social you are, the

974
00:54:54,120 --> 00:54:55,839
Speaker 2: less inflammation you should have.

975
00:54:56,440 --> 00:55:00,279
Speaker 1: That's right, and then you can live as healthy life

976
00:55:00,280 --> 00:55:03,480
Speaker 1: as you can and just wait for your family's genetics

977
00:55:03,480 --> 00:55:03,880
Speaker 1: to kill you.

978
00:55:05,719 --> 00:55:08,920
Speaker 2: But that's probably why because the after genetics had some

979
00:55:08,960 --> 00:55:12,640
Speaker 2: inflammation coded into it, and now it's you know, you

980
00:55:12,680 --> 00:55:13,920
Speaker 2: can be mad at your grandpa.

981
00:55:15,280 --> 00:55:18,239
Speaker 1: I loved my grandpa, Well that's great, But the one

982
00:55:18,239 --> 00:55:20,680
Speaker 1: that I knew, I'm happy.

983
00:55:20,360 --> 00:55:22,799
Speaker 2: For you, I didn't really I knew. Yeah, I guess

984
00:55:22,800 --> 00:55:24,799
Speaker 2: I knew one of mine. He was great too. I

985
00:55:24,840 --> 00:55:26,759
Speaker 2: only met one of mine a couple of times, and

986
00:55:26,880 --> 00:55:29,160
Speaker 2: I was too young to really make an impression of him.

987
00:55:29,520 --> 00:55:31,880
Speaker 1: Yeah. Same went. My dad's dad died when I was

988
00:55:32,440 --> 00:55:36,480
Speaker 1: five or six, and my mom's dad died when I

989
00:55:36,560 --> 00:55:38,480
Speaker 1: was I think I like, I think I was like

990
00:55:38,560 --> 00:55:42,520
Speaker 1: twelve and he was great. And it's one of those

991
00:55:42,520 --> 00:55:44,200
Speaker 1: things where I was like, every once in a while,

992
00:55:44,200 --> 00:55:47,760
Speaker 1: I'm like, man, I wish I could have known Walter

993
00:55:48,480 --> 00:55:49,920
Speaker 1: as with me as an adult.

994
00:55:50,040 --> 00:55:53,279
Speaker 2: Oh yeah, definitely. Yeah. You and me grew up down

995
00:55:53,320 --> 00:55:56,239
Speaker 2: the street from her grandparents for years and years and

996
00:55:56,320 --> 00:55:59,279
Speaker 2: years and like interacted with them. They helped kind of

997
00:55:59,320 --> 00:56:01,720
Speaker 2: like raise her, like there were a secondary set of parents.

998
00:56:01,760 --> 00:56:04,759
Speaker 2: And I was like, I'm so jealous of that, you know,

999
00:56:05,000 --> 00:56:07,640
Speaker 2: like you're so lucky if you're exposed to that as

1000
00:56:07,680 --> 00:56:08,120
Speaker 2: a kid.

1001
00:56:08,640 --> 00:56:12,279
Speaker 1: Yeah. So here's my last bit of advice. Okay, if

1002
00:56:12,280 --> 00:56:16,560
Speaker 1: you're sort of youngish and you love your grandma and

1003
00:56:16,600 --> 00:56:18,880
Speaker 1: grandpa and you're just gonna think they're always going to

1004
00:56:18,920 --> 00:56:23,319
Speaker 1: be around, they're not, so talk to them and ask

1005
00:56:23,360 --> 00:56:24,160
Speaker 1: them questions.

1006
00:56:24,440 --> 00:56:27,480
Speaker 2: Yeah, like what we're wearing galoshes?

1007
00:56:27,600 --> 00:56:32,160
Speaker 1: Like, yeah, we were rubbers.

1008
00:56:35,080 --> 00:56:37,680
Speaker 2: If your grandpa sounds like that he has neuro inflammation.

1009
00:56:38,000 --> 00:56:39,200
Speaker 1: That means he's Abe Simpson.

1010
00:56:39,719 --> 00:56:41,839
Speaker 2: Right, you got anything else?

1011
00:56:42,000 --> 00:56:42,839
Speaker 1: I got nothing else.

1012
00:56:43,480 --> 00:56:46,280
Speaker 2: If you want to know more about inflammation and chronic

1013
00:56:46,320 --> 00:56:49,520
Speaker 2: inflammation in particular, just start reading about it. There's a

1014
00:56:49,520 --> 00:56:51,880
Speaker 2: lot of interesting stuff out there. And since I said that,

1015
00:56:52,200 --> 00:56:56,759
Speaker 2: it's time for listener mail, all right.

1016
00:56:56,680 --> 00:56:59,080
Speaker 1: I'm gonna call this one. It's kind of fun to

1017
00:56:59,120 --> 00:57:03,200
Speaker 1: hear from liners who started young and are now adults. Yes,

1018
00:57:03,400 --> 00:57:05,759
Speaker 1: kind of ties into where we're just talking about. Hey, guys,

1019
00:57:05,840 --> 00:57:08,000
Speaker 1: I remember listening to your podcast with my dad on

1020
00:57:07,960 --> 00:57:10,759
Speaker 1: a long car trips to visit extended family when I

1021
00:57:10,800 --> 00:57:12,880
Speaker 1: was younger. He's always been the type of dad to

1022
00:57:12,880 --> 00:57:14,919
Speaker 1: get us curious about things so we could learn more

1023
00:57:15,360 --> 00:57:18,520
Speaker 1: about what we're interested in. In Your guys show was

1024
00:57:18,560 --> 00:57:21,040
Speaker 1: a great way to encourage that for me and my siblings.

1025
00:57:21,280 --> 00:57:23,280
Speaker 1: I'm pretty sure the first podcast I listened to you

1026
00:57:23,800 --> 00:57:28,320
Speaker 1: was from twenty thirteen, How Ghosts Work? Wow, And I

1027
00:57:28,400 --> 00:57:32,640
Speaker 1: remember being horrified ten year old agast at Chuck's story

1028
00:57:32,680 --> 00:57:33,800
Speaker 1: of the Old Lady in the Road.

1029
00:57:34,080 --> 00:57:35,480
Speaker 2: Yeah, that was a scary story.

1030
00:57:35,720 --> 00:57:38,360
Speaker 1: It was a good one. Now I'm twenty, I'm in college,

1031
00:57:38,600 --> 00:57:40,880
Speaker 1: still tuning in to learn new stuff that I should know.

1032
00:57:41,520 --> 00:57:45,320
Speaker 1: This podcast has been It's always so weird to hear this.

1033
00:57:45,320 --> 00:57:48,320
Speaker 1: This podcast has been a memorable part of my childhood.

1034
00:57:48,880 --> 00:57:50,880
Speaker 1: Who we heard and I wanted to thank you guys

1035
00:57:50,920 --> 00:57:52,880
Speaker 1: for doing what you're doing. I hope you're doing well.

1036
00:57:52,920 --> 00:57:56,840
Speaker 1: And that sincerely is from Kaya Powell.

1037
00:57:57,000 --> 00:57:59,480
Speaker 2: Thank you so much for that, Kaya, Like we hear

1038
00:57:59,480 --> 00:58:01,960
Speaker 2: that from people from time to time and it's just

1039
00:58:02,040 --> 00:58:04,520
Speaker 2: wonderful every time. Kind of gives you chills, a little

1040
00:58:04,560 --> 00:58:06,320
Speaker 2: bit done at huts.

1041
00:58:05,680 --> 00:58:07,760
Speaker 1: That's right, like seeing the old ghost lady in the road.

1042
00:58:08,240 --> 00:58:10,520
Speaker 2: I think about how much life has packed in between

1043
00:58:10,640 --> 00:58:13,080
Speaker 2: age ten and age twenty, and we were there for

1044
00:58:13,120 --> 00:58:16,880
Speaker 2: the whole time of't that neat? Well? Thanks for taking

1045
00:58:16,920 --> 00:58:19,800
Speaker 2: us along your journey, Kaya, And if you want to

1046
00:58:19,960 --> 00:58:22,840
Speaker 2: be like Kaya and write in for any reason whatsoever,

1047
00:58:23,280 --> 00:58:25,680
Speaker 2: you can wrap it up, spank it on the bottom,

1048
00:58:25,720 --> 00:58:30,560
Speaker 2: and send it off to Stuff Podcasts at iHeartRadio dot com.

1049
00:58:31,640 --> 00:58:34,640
Speaker 1: You Know, Stuff you Should Know is a production of iHeartRadio.

1050
00:58:35,120 --> 00:58:38,320
Speaker 1: For more podcasts my heart Radio, visit the iHeartRadio app,

1051
00:58:38,520 --> 00:58:41,440
Speaker 1: Apple Podcasts, or wherever you listen to your favorite shows.