1 00:00:00,040 --> 00:00:03,160 Speaker 1: M Hey, everybody, This is Chuck and welcome to this 2 00:00:03,200 --> 00:00:07,160 Speaker 1: week's Saturday Stuff You Should Know Selects episode. Uh. This 3 00:00:07,200 --> 00:00:09,040 Speaker 1: week was my pick, and I picked the episode on 4 00:00:09,520 --> 00:00:12,720 Speaker 1: the HeLa Cells because I think this one had a 5 00:00:12,800 --> 00:00:18,799 Speaker 1: great mix of history and science. History episodes are some 6 00:00:18,840 --> 00:00:20,360 Speaker 1: of my favorites, and we got to tell a little 7 00:00:20,360 --> 00:00:23,520 Speaker 1: bit of the story of the great Henrietta Lacks and 8 00:00:23,720 --> 00:00:25,599 Speaker 1: um on the science end, we got to kind of 9 00:00:25,640 --> 00:00:28,760 Speaker 1: delve into the importance of HeLa cells. So I hope 10 00:00:28,760 --> 00:00:30,960 Speaker 1: you enjoy it this time around. If you've heard it before, 11 00:00:31,360 --> 00:00:40,839 Speaker 1: give it another listen. Welcome to Stuff you Should Know 12 00:00:41,400 --> 00:00:49,600 Speaker 1: from House Stuff Works dot Com. Hey, and welcome to 13 00:00:49,600 --> 00:00:52,479 Speaker 1: the podcast. I'm Josh Clark and Charles W. Chuck Bryant's 14 00:00:52,520 --> 00:00:54,600 Speaker 1: with me, and Cherry's with me, and that means that 15 00:00:54,720 --> 00:00:56,400 Speaker 1: the three of us all together make it s w 16 00:00:56,520 --> 00:00:59,520 Speaker 1: Should Know. Hey, man, Hey, you can see it good? 17 00:00:59,520 --> 00:01:03,520 Speaker 1: You see? So I'm pretty excited about this one. Actually, 18 00:01:03,720 --> 00:01:06,160 Speaker 1: oh yeah, it's been a long time coming. We have 19 00:01:06,240 --> 00:01:08,919 Speaker 1: tons of people email us about this book. This lady 20 00:01:09,560 --> 00:01:14,280 Speaker 1: in read a lax and her helok felt HeLa Heila, 21 00:01:15,160 --> 00:01:19,200 Speaker 1: it's Henrietta Lacks. It's probably a laugh I hear that, 22 00:01:19,280 --> 00:01:21,880 Speaker 1: but I think it's Heila and Helos probably the way 23 00:01:21,880 --> 00:01:25,040 Speaker 1: to go. We'll go, well, we'll just do our own thing, okay. Um, 24 00:01:25,080 --> 00:01:27,240 Speaker 1: but yeah, this has been like a really big fan 25 00:01:27,280 --> 00:01:29,760 Speaker 1: request over the years. Yeah, but it ties in. We 26 00:01:29,800 --> 00:01:34,120 Speaker 1: did a show on right do you own your We 27 00:01:34,240 --> 00:01:36,200 Speaker 1: have a right to privacy after you die? Yeah, and 28 00:01:36,200 --> 00:01:38,440 Speaker 1: I think that's when we got the most feedback about this. Yeah, 29 00:01:38,480 --> 00:01:41,080 Speaker 1: for sure, it ties in heavily. It definitely ties in heavily. 30 00:01:41,080 --> 00:01:44,960 Speaker 1: There's a big movement about basically respecting the dead, you know, 31 00:01:45,000 --> 00:01:50,240 Speaker 1: whether you're a an ancient mummy or a woman from 32 00:01:50,280 --> 00:01:53,360 Speaker 1: Baltimore and the who died in the fifties, Like how 33 00:01:53,440 --> 00:01:55,680 Speaker 1: much of an expectation of privacy and how much of 34 00:01:55,680 --> 00:01:59,280 Speaker 1: a right to what makes you you? Do you have 35 00:01:59,400 --> 00:02:04,720 Speaker 1: after you die? And the plight of Henrietta lacks Um 36 00:02:04,880 --> 00:02:10,760 Speaker 1: has definitely raised this national discussion about it, and you know, great, 37 00:02:11,320 --> 00:02:13,120 Speaker 1: I guess it is the only way to put it, Like, 38 00:02:13,120 --> 00:02:16,200 Speaker 1: it's really good that people are talking about this. And 39 00:02:16,240 --> 00:02:19,600 Speaker 1: it's not just privacy. There's also um a lot of 40 00:02:19,639 --> 00:02:24,320 Speaker 1: allegations of racism, profiteering. It's a really morally complicated story, 41 00:02:24,400 --> 00:02:27,840 Speaker 1: but a pretty interesting one too, because at the end 42 00:02:27,840 --> 00:02:31,400 Speaker 1: of the day, this lady has done more to further 43 00:02:31,560 --> 00:02:38,760 Speaker 1: science been possibly any one person on the planet. Yeah, 44 00:02:38,800 --> 00:02:43,799 Speaker 1: Jonah Sauk, you say he is he la cells? Yeah? 45 00:02:43,960 --> 00:02:45,800 Speaker 1: Is that gonna bug you every time I say that? No, 46 00:02:45,919 --> 00:02:49,640 Speaker 1: it's fun. Okay. I I've adjusted my brain so I 47 00:02:49,720 --> 00:02:52,080 Speaker 1: hear it the way that I want to now, So 48 00:02:52,160 --> 00:02:56,680 Speaker 1: go ahead, great. Uh, what we're talking about are the 49 00:02:56,720 --> 00:02:59,680 Speaker 1: cells of a woman, an African American woman named Henrietta 50 00:02:59,720 --> 00:03:06,280 Speaker 1: Lacks who in uh in Baltimore, Maryland. She was pregnant 51 00:03:06,320 --> 00:03:10,400 Speaker 1: with her fifth child and she felt what she described 52 00:03:10,400 --> 00:03:15,040 Speaker 1: as a not to her family inside her midsection, and 53 00:03:15,280 --> 00:03:18,240 Speaker 1: after childbirth, it was discovered that she had a lump 54 00:03:18,240 --> 00:03:22,040 Speaker 1: on her cervix and had cervical cancer about a year 55 00:03:22,080 --> 00:03:25,560 Speaker 1: after she gave birth. Yeah, and um, the only place 56 00:03:25,560 --> 00:03:27,960 Speaker 1: that would treat African Americans at the time in that 57 00:03:28,040 --> 00:03:31,800 Speaker 1: area was JOHNS Hopkins in Baltimore, which is sad in 58 00:03:31,840 --> 00:03:36,120 Speaker 1: its own right. So, uh, while she was sick and 59 00:03:36,360 --> 00:03:40,080 Speaker 1: being treated, one of her doctor's doctor, how are you 60 00:03:40,080 --> 00:03:43,320 Speaker 1: going to pronounce this? Is it gay or gay? Gay? Gay? 61 00:03:43,440 --> 00:03:45,240 Speaker 1: He was in her doctor he was he ran the 62 00:03:45,280 --> 00:03:49,480 Speaker 1: tissue culture lab. Yeah, but he um, they sent part 63 00:03:49,480 --> 00:03:53,600 Speaker 1: of her service away to a lab to get tested, 64 00:03:54,040 --> 00:03:56,720 Speaker 1: and it turns out that it was pretty remarkable in 65 00:03:56,760 --> 00:03:59,960 Speaker 1: the way that her cells divided. Yeah. Yeah, you gotta 66 00:04:00,040 --> 00:04:03,720 Speaker 1: understand this guy, Dr Gay. It's g g e y. 67 00:04:03,920 --> 00:04:07,040 Speaker 1: I would say gay gay? Is that what you were saying? 68 00:04:08,680 --> 00:04:11,920 Speaker 1: It could be g I just gonna call him Dr Gay. 69 00:04:11,960 --> 00:04:16,159 Speaker 1: Isn't everyone named Clark's so easy? Yeah? I'm boring though. 70 00:04:17,080 --> 00:04:20,760 Speaker 1: Um So, Dr Gay is basically this guy who he 71 00:04:21,160 --> 00:04:24,720 Speaker 1: his wife and an assistant run this tissue culture laboratory 72 00:04:24,800 --> 00:04:29,960 Speaker 1: at Johns Hopkins. And for literally decades, this man has 73 00:04:30,000 --> 00:04:33,960 Speaker 1: been trying to find a line of human cells that 74 00:04:34,040 --> 00:04:38,279 Speaker 1: will continue to reproduce and not just die when placed 75 00:04:38,320 --> 00:04:42,560 Speaker 1: in culture. One day he got a sample of some 76 00:04:42,680 --> 00:04:47,800 Speaker 1: cells taken from the tumor in Henrietta Lacks's cervix, and 77 00:04:47,920 --> 00:04:50,640 Speaker 1: he put them in culture and they started to divide. 78 00:04:51,000 --> 00:04:53,599 Speaker 1: And they divided again after that, and they divided again 79 00:04:53,640 --> 00:04:56,600 Speaker 1: after that. In every twenty four hours, the population of 80 00:04:56,720 --> 00:05:01,960 Speaker 1: soul cells and culture divided doubled. And this guy said, 81 00:05:02,120 --> 00:05:05,039 Speaker 1: Holy cow, this is it, Like, this is the first 82 00:05:05,080 --> 00:05:08,240 Speaker 1: time I've seen a line of immortal human cells. This 83 00:05:08,320 --> 00:05:12,159 Speaker 1: could advance science forever. By this time, I think henri 84 00:05:12,360 --> 00:05:15,440 Speaker 1: Alax was dead because was it a biopsy or was 85 00:05:15,480 --> 00:05:18,040 Speaker 1: it from her autopsy? Do you know it was from 86 00:05:18,080 --> 00:05:23,040 Speaker 1: the biopsy? But um, she passed away on October fourth, nine, 87 00:05:24,279 --> 00:05:27,359 Speaker 1: and I think all of this happened postmortem, and we 88 00:05:27,360 --> 00:05:30,520 Speaker 1: should like, I don't in any way want to diminish 89 00:05:30,560 --> 00:05:32,760 Speaker 1: what happened in between the time of her biopsy and 90 00:05:32,800 --> 00:05:36,920 Speaker 1: the time doctor gaze like eureka, like this woman had um. 91 00:05:37,000 --> 00:05:40,440 Speaker 1: She she got treatment, UM, but I mean the treatment 92 00:05:40,440 --> 00:05:44,919 Speaker 1: at the time was fairly primitive. Apparently radiation treatment meant 93 00:05:44,960 --> 00:05:51,320 Speaker 1: that you, um, you sewed little radioactive tubes into the 94 00:05:51,360 --> 00:05:55,000 Speaker 1: cervix and left them there. That was radiation treatment. There 95 00:05:55,040 --> 00:05:57,480 Speaker 1: was X ray treatment. She was in a tremendous amount 96 00:05:57,480 --> 00:06:01,520 Speaker 1: of pain. Um, and she she died horribly from this 97 00:06:01,720 --> 00:06:07,600 Speaker 1: extremely aggressive case of cervical cancer. At the time UM, 98 00:06:07,680 --> 00:06:11,920 Speaker 1: and she died in her family was poverty stricken. Uh. 99 00:06:11,960 --> 00:06:14,240 Speaker 1: They a lot of them didn't grow up to be 100 00:06:14,480 --> 00:06:17,920 Speaker 1: very well educated. And by the time this rolled around, 101 00:06:19,040 --> 00:06:26,120 Speaker 1: the the public awareness of Henriett Alacks's plight or post death, UM, 102 00:06:26,160 --> 00:06:29,279 Speaker 1: her family couldn't even afford healthcare for the most part, 103 00:06:29,320 --> 00:06:32,120 Speaker 1: which is a great irony of this whole thing. So 104 00:06:32,200 --> 00:06:34,880 Speaker 1: let's let's talk about what what happened after she died 105 00:06:34,960 --> 00:06:38,600 Speaker 1: in her m her cells continued on. Well, he named them, 106 00:06:38,640 --> 00:06:40,520 Speaker 1: first of all, and it's it's a common thing to 107 00:06:40,600 --> 00:06:44,080 Speaker 1: name the cells after the person from which they came, 108 00:06:44,760 --> 00:06:48,400 Speaker 1: and so a lot for many years people I thought 109 00:06:48,600 --> 00:06:50,880 Speaker 1: they said it was a lady named Helen Lane or 110 00:06:50,960 --> 00:06:54,839 Speaker 1: Helen Larson, right, because they're trying to create anonymity, like 111 00:06:54,880 --> 00:06:58,840 Speaker 1: you're trying to protect the donors identity, and they were 112 00:06:58,839 --> 00:07:01,560 Speaker 1: actually trying to throw pull off by saying they were 113 00:07:01,640 --> 00:07:04,360 Speaker 1: lying it was Helen Lane or Helen Larson. Yeah, I 114 00:07:04,400 --> 00:07:07,320 Speaker 1: don't know about that. And on an anonymity, why would 115 00:07:07,320 --> 00:07:09,520 Speaker 1: they name them after the person? Then? I don't know. 116 00:07:09,600 --> 00:07:12,120 Speaker 1: I think that they're trying to protect their their name. 117 00:07:12,120 --> 00:07:14,040 Speaker 1: Why would they name them after I think rather than 118 00:07:14,080 --> 00:07:18,080 Speaker 1: calling it at the time that Henrietta lacks cells, HELO 119 00:07:18,320 --> 00:07:20,880 Speaker 1: was good enough. Interesting. I would think if you're trying 120 00:07:20,920 --> 00:07:23,160 Speaker 1: to protect them, you wouldn't call it anything remotely close 121 00:07:23,160 --> 00:07:26,920 Speaker 1: to the right exactly. Well that's what they do now, Okay. Um, 122 00:07:27,040 --> 00:07:30,760 Speaker 1: So anyway, people didn't really check a lot because it's 123 00:07:30,800 --> 00:07:33,760 Speaker 1: just no one really cares that much in the medical community, 124 00:07:33,840 --> 00:07:36,480 Speaker 1: like who did these come from? It was really common 125 00:07:37,040 --> 00:07:40,440 Speaker 1: at the time and still to take tissue samples and 126 00:07:40,680 --> 00:07:44,080 Speaker 1: use them without consent. And that's one of the big 127 00:07:44,120 --> 00:07:47,400 Speaker 1: issues that came about later is she never knew that 128 00:07:47,440 --> 00:07:49,920 Speaker 1: her cells were going to be used in this way. Right. 129 00:07:49,920 --> 00:07:51,880 Speaker 1: Not only did she not know, her family had no 130 00:07:51,960 --> 00:07:54,320 Speaker 1: idea too. Yeah, but we should point out it wasn't 131 00:07:54,320 --> 00:07:56,080 Speaker 1: like against the law or anything, and there was nothing 132 00:07:56,080 --> 00:08:00,280 Speaker 1: shady going on because it was commonplace. Right. We should 133 00:08:00,280 --> 00:08:02,760 Speaker 1: also point out that Dr gay I never sought to 134 00:08:02,840 --> 00:08:05,400 Speaker 1: profit from these things. Now, he would send them off 135 00:08:05,400 --> 00:08:08,320 Speaker 1: to people for free. Um, you have to buy them 136 00:08:08,360 --> 00:08:11,680 Speaker 1: now of course. Uh. And they're all different kinds of 137 00:08:11,720 --> 00:08:15,400 Speaker 1: strains that range in prices from two fifty bucks to 138 00:08:15,480 --> 00:08:18,840 Speaker 1: like thousands of dollars for example. Yeah, and we'll we'll 139 00:08:18,840 --> 00:08:21,520 Speaker 1: talk about that in a little while, and like you 140 00:08:21,560 --> 00:08:23,800 Speaker 1: can get online and buy them. Yeah, right, I went 141 00:08:23,840 --> 00:08:25,920 Speaker 1: today and I added some to the cart, and then 142 00:08:25,960 --> 00:08:29,040 Speaker 1: I was like, I'm just kidding, did you that car 143 00:08:29,200 --> 00:08:32,080 Speaker 1: is like Bryant? Yeah. I just was curious, so how 144 00:08:32,080 --> 00:08:33,959 Speaker 1: easy it would be, And I don't know if there 145 00:08:34,000 --> 00:08:36,839 Speaker 1: was a something later on in that process that I 146 00:08:36,880 --> 00:08:40,080 Speaker 1: would have to fill out or something, but I added 147 00:08:40,080 --> 00:08:42,520 Speaker 1: it to the cart. Uh. No, I don't think you 148 00:08:42,520 --> 00:08:45,360 Speaker 1: have to fill anything out to get human culture. Really. Yeah, 149 00:08:45,640 --> 00:08:48,000 Speaker 1: you don't have to prove that you're like a researcher 150 00:08:48,080 --> 00:08:50,000 Speaker 1: or some kind. I don't think so. No, as long 151 00:08:50,000 --> 00:08:53,360 Speaker 1: as it's not like, um, a bio hazard, I think interesting. 152 00:08:53,440 --> 00:08:56,360 Speaker 1: And I know some places that charge it different prices 153 00:08:56,400 --> 00:09:00,240 Speaker 1: for nonprofits as well for the Yeah, but just that 154 00:09:00,360 --> 00:09:02,560 Speaker 1: much of a discount, Like I saw somewhere, it would 155 00:09:02,600 --> 00:09:05,040 Speaker 1: be like maybe you or I would pay two fifty bucks, 156 00:09:05,040 --> 00:09:06,480 Speaker 1: but if we had, if we were a five O 157 00:09:06,559 --> 00:09:10,319 Speaker 1: one C three, we'd pay like a hundred ninety. That's 158 00:09:10,360 --> 00:09:14,400 Speaker 1: not bad sixty. Yeah, I just thought it'd be more. Okay, 159 00:09:15,720 --> 00:09:18,360 Speaker 1: all right, so let's talk a little bit about why. Well, 160 00:09:18,440 --> 00:09:20,480 Speaker 1: first of all, we don't really know for sure why 161 00:09:20,800 --> 00:09:23,280 Speaker 1: herselves were so unique. Okay, so they think they might 162 00:09:23,280 --> 00:09:26,520 Speaker 1: have figured it out. I saw that in nature, Yes 163 00:09:26,679 --> 00:09:29,560 Speaker 1: I didn't. I don't know. I don't know. If I 164 00:09:29,640 --> 00:09:32,160 Speaker 1: thought that was solid, you didn't buy it. Well, I 165 00:09:32,240 --> 00:09:34,760 Speaker 1: don't think they even went on record saying it's super solid. 166 00:09:34,760 --> 00:09:37,280 Speaker 1: It's just a theory. So I from from what I 167 00:09:37,360 --> 00:09:41,760 Speaker 1: understand the what's her name, Rebecca Sclute? Yeah, she's who 168 00:09:41,800 --> 00:09:44,839 Speaker 1: wrote the book The Immortal Henry at a Las, Yes, 169 00:09:44,840 --> 00:09:48,920 Speaker 1: which is being options by Oprah Yeah for HBO. Yeah, 170 00:09:48,960 --> 00:09:51,880 Speaker 1: that would be a good one for a movie. Um. 171 00:09:52,000 --> 00:09:56,079 Speaker 1: So she apparently buys it. And because she was saying 172 00:09:56,080 --> 00:09:58,760 Speaker 1: that for many many years after the book came out, 173 00:09:58,800 --> 00:10:00,480 Speaker 1: well for a couple of years after a book came out, 174 00:10:00,480 --> 00:10:02,200 Speaker 1: because it came out in two thousand and ten, and 175 00:10:02,280 --> 00:10:06,280 Speaker 1: this explanation came out this year. Um that they had 176 00:10:06,280 --> 00:10:08,320 Speaker 1: to tell people on book tour, like, we have no 177 00:10:08,400 --> 00:10:11,120 Speaker 1: idea why herself kept growing and growing and now we 178 00:10:11,160 --> 00:10:14,839 Speaker 1: have a better understanding. But the explanation, Chuck and I 179 00:10:14,880 --> 00:10:18,920 Speaker 1: are referring to everybody. Um, so you get cervical cancer 180 00:10:19,000 --> 00:10:22,280 Speaker 1: from the human pepioma virus. There's two else, so it's 181 00:10:22,320 --> 00:10:27,800 Speaker 1: b O right, Okay, HPV and UM apparently, which is 182 00:10:27,880 --> 00:10:31,200 Speaker 1: very common by the way, Yes, um, but that's what 183 00:10:31,360 --> 00:10:35,480 Speaker 1: cervical cancer comes from Florida, I understand right. Okay, So 184 00:10:36,840 --> 00:10:42,400 Speaker 1: the HPV and Henrietta Lacks had insinuated its own genetic 185 00:10:42,480 --> 00:10:47,559 Speaker 1: material into her DNA right above a gene called mike 186 00:10:47,720 --> 00:10:52,000 Speaker 1: m YC and this gene, it's a regulatory gene, so 187 00:10:52,400 --> 00:10:55,400 Speaker 1: when it starts to when it's expression starts to get 188 00:10:55,400 --> 00:10:58,680 Speaker 1: hay wire, it can lead to cancer. So they think 189 00:10:59,080 --> 00:11:04,040 Speaker 1: that the placement of this HPV is what causes these 190 00:11:04,080 --> 00:11:08,720 Speaker 1: cells to grow and divide so quickly and so robustly, 191 00:11:09,160 --> 00:11:14,240 Speaker 1: because these HeLa cells are an immortal line of cells. 192 00:11:14,280 --> 00:11:16,800 Speaker 1: When you put them in the right conditions, you take 193 00:11:16,840 --> 00:11:21,000 Speaker 1: one cell, it will keep dividing indefinitely, And we should 194 00:11:21,040 --> 00:11:23,720 Speaker 1: probably talk about why that's a big thing, why other 195 00:11:23,840 --> 00:11:27,360 Speaker 1: people's cells don't normally do that. So before we move on, 196 00:11:27,520 --> 00:11:34,880 Speaker 1: I think it's a good time for a message break. Hey, 197 00:11:34,920 --> 00:11:39,640 Speaker 1: now we're back. Should we get into apoptosis? Apoptosis or 198 00:11:39,720 --> 00:11:44,200 Speaker 1: cellular suicide is or program cell death because you pick 199 00:11:44,600 --> 00:11:47,640 Speaker 1: many names. So from what I understand, program cell death 200 00:11:47,840 --> 00:11:51,320 Speaker 1: is like this whole general idea that a cell self destruction, 201 00:11:51,360 --> 00:11:55,680 Speaker 1: but there's different ways, and up poptosis is one of them. UM. Basically, 202 00:11:55,679 --> 00:12:00,000 Speaker 1: when a cell is no longer needed, it commits cellular suicide. Uh, 203 00:12:00,160 --> 00:12:04,600 Speaker 1: it's not abnormal or scary, UM. Healthy adults, we have 204 00:12:04,679 --> 00:12:07,360 Speaker 1: billions of cells dying in our bone matter and intestines 205 00:12:07,400 --> 00:12:09,720 Speaker 1: every hour. Yeah, and then your white blood cells come along, 206 00:12:09,840 --> 00:12:14,320 Speaker 1: absorb all the detritus and move you move this this 207 00:12:14,360 --> 00:12:17,600 Speaker 1: stuff out through your sweat. Yeah. It basically balances cell 208 00:12:17,600 --> 00:12:21,120 Speaker 1: division out um tissue would grow or shrink if it 209 00:12:21,200 --> 00:12:24,959 Speaker 1: wasn't for apoptosis. So it's a good thing, right. Um. 210 00:12:25,000 --> 00:12:29,319 Speaker 1: Apparently we have web fingers as we develop in the womb, right, 211 00:12:29,960 --> 00:12:35,920 Speaker 1: and thanks to apoptosis, these cells degrade and your fingers 212 00:12:35,960 --> 00:12:40,280 Speaker 1: go back to to non webby versions of themselves. Well, 213 00:12:40,320 --> 00:12:44,040 Speaker 1: they don't go back to or go to. Yeah. Basically 214 00:12:44,080 --> 00:12:47,640 Speaker 1: all the cells, all the cells die in between your fingers, 215 00:12:48,240 --> 00:12:50,679 Speaker 1: and you don't look like a man from Atlantis. Right. 216 00:12:50,720 --> 00:12:52,240 Speaker 1: And this is also, like you said, I think a 217 00:12:52,440 --> 00:12:57,200 Speaker 1: check on cancerous growth because cancer is well tumor is 218 00:12:57,280 --> 00:13:00,520 Speaker 1: a cluster of cells that are growing out of control. 219 00:13:00,640 --> 00:13:03,680 Speaker 1: One of the conditions of life is controlled growth. Cancer 220 00:13:03,720 --> 00:13:06,960 Speaker 1: is uncontrolled growth. One way to keep that in check 221 00:13:07,040 --> 00:13:10,640 Speaker 1: is to have cells have a lifespan, and they typically 222 00:13:10,679 --> 00:13:16,160 Speaker 1: do in the healthy person. The cells divide um between 223 00:13:16,200 --> 00:13:21,440 Speaker 1: forty and sixty times and then they die. That's what's 224 00:13:21,480 --> 00:13:24,240 Speaker 1: called the hay Flick limit. Yeah, we've talked about that. Yeah, 225 00:13:24,320 --> 00:13:26,600 Speaker 1: and do you remember what it was. We've talked about 226 00:13:26,600 --> 00:13:28,800 Speaker 1: that a few times. Yeah, well, it's just so fascinating. 227 00:13:28,840 --> 00:13:33,280 Speaker 1: It is. Uh So cancer cells, like we said, don't 228 00:13:33,320 --> 00:13:37,440 Speaker 1: have the pc D and hers, thanks to Mike, are 229 00:13:37,559 --> 00:13:41,280 Speaker 1: just the hardiest they had ever discovered, and uh I 230 00:13:41,360 --> 00:13:44,040 Speaker 1: went on to be used in at least sixty cases 231 00:13:44,240 --> 00:13:49,880 Speaker 1: uh in medical journals and articles. Well, this is probably 232 00:13:49,880 --> 00:13:54,640 Speaker 1: written three months ago. You know. Um eleven thousand patents 233 00:13:54,840 --> 00:13:57,880 Speaker 1: relate to the use of the he LA cells. And 234 00:13:58,360 --> 00:14:01,520 Speaker 1: they're easy to store, they're easy to ship. They're basically 235 00:14:02,720 --> 00:14:06,319 Speaker 1: the best cells out there to work with for most 236 00:14:06,480 --> 00:14:10,800 Speaker 1: kinds of disease, although in viruses UM, although some doctors 237 00:14:10,800 --> 00:14:12,960 Speaker 1: say they can be a little too robust and mess 238 00:14:12,960 --> 00:14:17,760 Speaker 1: things up. So they these cells are. They're extremely robust, 239 00:14:17,840 --> 00:14:21,520 Speaker 1: They divide very quickly, They're very hardy. They also apparently 240 00:14:21,560 --> 00:14:24,800 Speaker 1: are airborne. Is one one way that they go and 241 00:14:24,840 --> 00:14:28,880 Speaker 1: contaminate other cultures. They can easily be transferred on clothes 242 00:14:29,000 --> 00:14:33,000 Speaker 1: or gloves or whatever, so they to some researchers, they 243 00:14:33,160 --> 00:14:37,600 Speaker 1: basically are like invasive. They're an invasive cell line. Uh 244 00:14:37,600 --> 00:14:42,120 Speaker 1: and by the early seventies they contaminated so many other 245 00:14:42,280 --> 00:14:45,840 Speaker 1: cell lines UM that doctors had to figure out how 246 00:14:45,960 --> 00:14:50,480 Speaker 1: way to identify HeLa cells from other cells. So they said, well, 247 00:14:50,480 --> 00:14:54,040 Speaker 1: we'll just call the family and and I think nine 248 00:14:54,760 --> 00:14:59,120 Speaker 1: day las Henriette's husband got a phone call that just 249 00:14:59,240 --> 00:15:01,880 Speaker 1: completely con used him. And this is the first seat 250 00:15:01,920 --> 00:15:04,160 Speaker 1: ever heard. This is the first the family found out 251 00:15:04,840 --> 00:15:08,600 Speaker 1: that these cells, that that this was going on the family. 252 00:15:08,680 --> 00:15:13,000 Speaker 1: This family had no idea. Yeah, but like we said, 253 00:15:13,000 --> 00:15:16,240 Speaker 1: they weren't highly educated. So when someone calls from Johns 254 00:15:16,240 --> 00:15:20,600 Speaker 1: Hopkins and says, your wife is still alive as cells 255 00:15:20,640 --> 00:15:23,480 Speaker 1: in a lab, they were really confused. And the daughter 256 00:15:23,600 --> 00:15:27,960 Speaker 1: even thought for a while that they had literally cloned 257 00:15:29,080 --> 00:15:33,040 Speaker 1: her mom and that versions of the mom were living 258 00:15:33,040 --> 00:15:37,680 Speaker 1: in London. Like, you know, she had no idea what 259 00:15:37,760 --> 00:15:40,400 Speaker 1: they were talking about, right, if so? But not only that, 260 00:15:40,440 --> 00:15:43,560 Speaker 1: the call apparently was later proven to be very misleading 261 00:15:44,120 --> 00:15:46,640 Speaker 1: because they were saying, we need to find out if 262 00:15:46,680 --> 00:15:49,920 Speaker 1: your kids have cancer. So well, what they wanted was 263 00:15:50,320 --> 00:15:53,160 Speaker 1: to see if they had the same properties as their mom. 264 00:15:53,360 --> 00:15:57,000 Speaker 1: They wanted they wanted the kids DNA so they could 265 00:15:57,160 --> 00:16:01,360 Speaker 1: identify HeLa DNA and other cultures because it had become 266 00:16:01,400 --> 00:16:06,440 Speaker 1: so invasive, right, so they were basically saying, you guys 267 00:16:06,480 --> 00:16:08,960 Speaker 1: might have cancer. But really what they were after was 268 00:16:09,000 --> 00:16:12,760 Speaker 1: their genetic material for for DNA typing. That's right. That's 269 00:16:12,800 --> 00:16:16,920 Speaker 1: extremely misleading and mean because once the kids went in 270 00:16:17,400 --> 00:16:21,440 Speaker 1: and got their um blood workups done, Johns Hopkins never 271 00:16:21,520 --> 00:16:25,960 Speaker 1: called back, so they were just left to wonder what 272 00:16:26,040 --> 00:16:28,440 Speaker 1: was going on. But I mean, think about it. So 273 00:16:28,480 --> 00:16:30,560 Speaker 1: let's say somebody called you and said, hey, um, we 274 00:16:30,720 --> 00:16:32,360 Speaker 1: think you might have cancer, come in and do some 275 00:16:32,400 --> 00:16:34,640 Speaker 1: blood work. You go in and get your blood work done, 276 00:16:34,720 --> 00:16:37,120 Speaker 1: and then they never call you back again. Wouldn't you 277 00:16:37,200 --> 00:16:42,200 Speaker 1: be worried? I get on the phone. Sure. So, like 278 00:16:42,240 --> 00:16:46,000 Speaker 1: we said, Chuck, this is a pretty morally complex situation. Um. 279 00:16:46,080 --> 00:16:48,760 Speaker 1: When the family did finally find out, they also realized 280 00:16:48,800 --> 00:16:52,880 Speaker 1: that this this their mother's cell line. Um was a 281 00:16:53,000 --> 00:16:56,760 Speaker 1: multi billion dollar cottage industry and they hadn't seen a 282 00:16:56,760 --> 00:17:00,960 Speaker 1: penny from it. Um. And so medical science kind of said, well, 283 00:17:00,960 --> 00:17:04,440 Speaker 1: ho hold on, let me let's let us explain all 284 00:17:04,480 --> 00:17:07,240 Speaker 1: the great things that your mother's cells have done. Right, 285 00:17:07,640 --> 00:17:10,200 Speaker 1: And I mean there's they've been involved in some pretty 286 00:17:10,200 --> 00:17:15,800 Speaker 1: spectacular scientific achievements. Yes, like we said, the study of viruses, 287 00:17:15,920 --> 00:17:21,680 Speaker 1: everything from measles to mumps, um created vaccines. In fact, 288 00:17:21,760 --> 00:17:25,960 Speaker 1: curing creating a vaccine for HPV. Yeah, so that she had. 289 00:17:26,359 --> 00:17:28,679 Speaker 1: They ended up getting a vaccine for that from ourselves, 290 00:17:28,680 --> 00:17:32,400 Speaker 1: which is pretty great. Like you said, Jonas Salk. With polio, 291 00:17:32,640 --> 00:17:35,800 Speaker 1: which has been eradicated here in the West, we should 292 00:17:35,840 --> 00:17:39,199 Speaker 1: explain how that happens to Like um, when you have 293 00:17:39,240 --> 00:17:44,440 Speaker 1: a live human cell, you have an opportunity to do 294 00:17:44,520 --> 00:17:47,320 Speaker 1: whatever you can to it and simulate what would happen 295 00:17:47,359 --> 00:17:50,760 Speaker 1: in a normal human body. And with polio, they took 296 00:17:50,800 --> 00:17:54,439 Speaker 1: the polio virus and injected the heli cell with the 297 00:17:54,480 --> 00:17:57,640 Speaker 1: polio virus, and then they injected the heli cell with 298 00:17:57,680 --> 00:18:02,879 Speaker 1: some of Jonas Salk's polio vaccine, and the polio virus 299 00:18:02,960 --> 00:18:07,040 Speaker 1: was eradicated in that heli cell. That's right, Yeah, you 300 00:18:07,200 --> 00:18:11,399 Speaker 1: just figured out that your vaccine works. They've used it 301 00:18:11,720 --> 00:18:16,760 Speaker 1: to study tuberculosis. Yeah HIV, we already said HBB Parkinson's. 302 00:18:16,760 --> 00:18:21,800 Speaker 1: They've used a lot in Parkinson's research, and even in 303 00:18:22,200 --> 00:18:28,080 Speaker 1: the transportation and standardization of just using cells like this period, 304 00:18:28,640 --> 00:18:30,480 Speaker 1: because you know, they were so great and they wanted 305 00:18:30,480 --> 00:18:32,960 Speaker 1: to use these, they had to figure out a better 306 00:18:33,000 --> 00:18:35,960 Speaker 1: way to ship them back and forth. And just a 307 00:18:35,960 --> 00:18:38,920 Speaker 1: lot of the standardization of these procedures are in place 308 00:18:38,960 --> 00:18:41,879 Speaker 1: now because of everyone wanted to work with these cells, 309 00:18:42,640 --> 00:18:45,320 Speaker 1: which is pretty great too, So okay, chuck. Um the 310 00:18:45,359 --> 00:18:48,960 Speaker 1: family finds out about this, they spend basically decades saying like, hey, 311 00:18:49,040 --> 00:18:51,240 Speaker 1: can somebody fill us in on what's going on here? 312 00:18:51,600 --> 00:18:53,560 Speaker 1: How are you guys making money off of this? Like 313 00:18:53,600 --> 00:18:58,240 Speaker 1: what's the deal? And we're just being ignored, And finally 314 00:18:58,280 --> 00:19:01,840 Speaker 1: Rebecca Sclute gets some involved. Yeah, she's a science writer. 315 00:19:01,920 --> 00:19:03,679 Speaker 1: I don't think we even mentioned that. Yeah, and the 316 00:19:03,760 --> 00:19:07,480 Speaker 1: author of the Immortal Henrietta Lacks right, Yeah, I think 317 00:19:07,480 --> 00:19:09,920 Speaker 1: it's The Immortal Life, The Immortal Life of Henriette A. 318 00:19:09,960 --> 00:19:14,919 Speaker 1: Lacks Um. And over time Sclute kind of befriends the 319 00:19:14,960 --> 00:19:18,199 Speaker 1: family and ends up writing this book and telling the 320 00:19:18,240 --> 00:19:24,320 Speaker 1: story of Henriett of Henrietta Alacks and basically just captures 321 00:19:24,320 --> 00:19:28,040 Speaker 1: the national attention. Basically says, this family, you can make 322 00:19:28,080 --> 00:19:31,800 Speaker 1: a pretty good case, was totally exploited as a whole, 323 00:19:32,520 --> 00:19:36,040 Speaker 1: or by the medical establishment as a whole, and let's 324 00:19:36,080 --> 00:19:41,200 Speaker 1: talk about this, and that's exactly what happened as a result. Yeah, um, 325 00:19:41,840 --> 00:19:46,760 Speaker 1: the family did look into getting money from it, but 326 00:19:46,920 --> 00:19:50,919 Speaker 1: that is pretty much completely off the table because that 327 00:19:51,000 --> 00:19:55,120 Speaker 1: opens up a can of worms that everybody's cells ever 328 00:19:55,320 --> 00:19:58,200 Speaker 1: used in any experiment would have to be tracked back 329 00:19:58,240 --> 00:20:03,760 Speaker 1: to their original family members and compensated. In the courts 330 00:20:03,800 --> 00:20:06,800 Speaker 1: of resoundingly said no, no, no, we can't do that. 331 00:20:07,200 --> 00:20:10,439 Speaker 1: Set halt medical research because we know it and we 332 00:20:10,480 --> 00:20:13,040 Speaker 1: can't do that. There was a case in nineteen eighty 333 00:20:13,160 --> 00:20:18,680 Speaker 1: where this this patient with leukemia um found out that 334 00:20:18,800 --> 00:20:22,280 Speaker 1: his doctor had taken cells from a biopsy and created 335 00:20:22,320 --> 00:20:26,360 Speaker 1: a cell line worth three billion dollars, and this case 336 00:20:26,400 --> 00:20:28,200 Speaker 1: went all the ways Supreme Court. In the Supreme Court 337 00:20:28,240 --> 00:20:31,240 Speaker 1: said sorry, man, yeah, once it's taken from your body, 338 00:20:31,240 --> 00:20:33,719 Speaker 1: it doesn't belong to you any longer. To a lot 339 00:20:33,760 --> 00:20:36,320 Speaker 1: of people still don't necessarily agree with, but that's the 340 00:20:37,240 --> 00:20:40,280 Speaker 1: that's the status quo as it stands to think. Everybody's 341 00:20:40,440 --> 00:20:46,880 Speaker 1: very protective of scientific um progress, especially in in eradicating 342 00:20:46,920 --> 00:20:51,120 Speaker 1: diseases as they should be. However, earlier this year there 343 00:20:51,240 --> 00:20:55,359 Speaker 1: was finally some good news for the Lax family. UH 344 00:20:55,400 --> 00:21:00,280 Speaker 1: The National Institute of Health UM in I had to 345 00:21:00,320 --> 00:21:02,280 Speaker 1: two of her descendants to be part of the HeLa 346 00:21:02,400 --> 00:21:06,320 Speaker 1: Genome Data Access Working Group, which basically now they're a 347 00:21:06,359 --> 00:21:10,480 Speaker 1: part of the UM the board which considers applications to 348 00:21:10,600 --> 00:21:14,240 Speaker 1: use her cells. Yeah, because in addition, while this whole 349 00:21:14,240 --> 00:21:17,320 Speaker 1: thing is going on, this whole national conversation about what 350 00:21:17,359 --> 00:21:20,560 Speaker 1: should be done with the cell line, and um, you 351 00:21:20,600 --> 00:21:24,800 Speaker 1: know what rights a a person has to their own cells. 352 00:21:24,840 --> 00:21:31,400 Speaker 1: This European Scientific Agency cracked and published the HeLa genome, 353 00:21:31,720 --> 00:21:37,120 Speaker 1: which they published Henrietta Lacks's genome just out there, open 354 00:21:37,160 --> 00:21:39,200 Speaker 1: to the public. And it's been proven that you can 355 00:21:39,600 --> 00:21:43,600 Speaker 1: you can find someone's identity out just from their genome, 356 00:21:44,200 --> 00:21:46,360 Speaker 1: and you can also find out a lot about their descendants. 357 00:21:46,400 --> 00:21:48,960 Speaker 1: So it was a big deal. This European agency took 358 00:21:48,960 --> 00:21:52,600 Speaker 1: it down. But now it's been placed behind this UM. 359 00:21:52,680 --> 00:21:56,119 Speaker 1: It's it's under like a password, lock and key in 360 00:21:56,200 --> 00:21:59,120 Speaker 1: this database, so there's access to it. You can get 361 00:21:59,160 --> 00:22:01,680 Speaker 1: access to but you to apply to that working group. 362 00:22:01,960 --> 00:22:05,479 Speaker 1: That's right. So now the Data Access Group UM, they 363 00:22:05,520 --> 00:22:09,639 Speaker 1: apply for permission, they agree not to contact the family 364 00:22:09,680 --> 00:22:13,040 Speaker 1: members of Henrietta Lacks, agreed to use them only for 365 00:22:13,080 --> 00:22:18,080 Speaker 1: biomedical research only, and UM, some of the family members 366 00:22:18,080 --> 00:22:21,320 Speaker 1: will handle those requests along with uh, you know, the 367 00:22:21,359 --> 00:22:23,199 Speaker 1: other people on the board. It's not like they're the 368 00:22:23,240 --> 00:22:25,200 Speaker 1: only ones that are left to decide this of course, 369 00:22:26,040 --> 00:22:29,600 Speaker 1: and um, like I said, they did ask about paying, 370 00:22:29,600 --> 00:22:31,600 Speaker 1: and they said, maybe we can think of some other 371 00:22:31,640 --> 00:22:34,840 Speaker 1: ways for you to make money off this, like patenting 372 00:22:34,960 --> 00:22:38,240 Speaker 1: a genetic test for cancer based on your mom's cells. 373 00:22:38,240 --> 00:22:40,359 Speaker 1: But they have not yet come up with any way 374 00:22:40,480 --> 00:22:43,480 Speaker 1: to make money off of it. So a lot of 375 00:22:43,520 --> 00:22:45,600 Speaker 1: other people have, Like you were saying, you can go 376 00:22:45,680 --> 00:22:48,720 Speaker 1: online and buy a vial of cells for like two 377 00:22:49,480 --> 00:22:52,920 Speaker 1: bucks or something like that. There's other ones that, um, 378 00:22:53,000 --> 00:22:55,480 Speaker 1: you can buy that have HeLa cells that are like 379 00:22:55,760 --> 00:22:59,200 Speaker 1: ten thousand dollars. And I read this explanation of all 380 00:22:59,240 --> 00:23:01,639 Speaker 1: that that if you take one of those ten tho 381 00:23:01,920 --> 00:23:07,000 Speaker 1: dollar vials, it has all these other patented processes and 382 00:23:07,080 --> 00:23:11,399 Speaker 1: proteins and genes and things, and that that account for 383 00:23:11,480 --> 00:23:16,240 Speaker 1: that increased amount of money, that increased cost. And then 384 00:23:16,280 --> 00:23:19,320 Speaker 1: even the vile it's like, well, it costs money to 385 00:23:19,680 --> 00:23:21,840 Speaker 1: produce these things and store them and ship them and 386 00:23:21,880 --> 00:23:26,200 Speaker 1: all that. So the the idea that there's somebody out 387 00:23:26,200 --> 00:23:28,919 Speaker 1: there that's just making tons of cash off this is not. 388 00:23:29,040 --> 00:23:33,880 Speaker 1: That it's much more spread out and it's much less obvious, 389 00:23:34,040 --> 00:23:37,040 Speaker 1: and um, there's really not that much of a bad 390 00:23:37,080 --> 00:23:39,680 Speaker 1: guy in this story as much as you want there 391 00:23:39,680 --> 00:23:42,160 Speaker 1: to be. And even the author of the book is like, 392 00:23:42,280 --> 00:23:45,280 Speaker 1: there's there's a lot of like shifting sands in this 393 00:23:45,760 --> 00:23:48,080 Speaker 1: and it's not cutting dry and black and white. And 394 00:23:48,600 --> 00:23:49,840 Speaker 1: you know, at the end of the day, we want 395 00:23:49,840 --> 00:23:53,320 Speaker 1: biomedical research to keep progressing. Yeah. I don't think anyone 396 00:23:53,359 --> 00:23:55,280 Speaker 1: necessarily looking for a bad guy as much as they're 397 00:23:55,280 --> 00:23:58,480 Speaker 1: looking for a good ending for that family. Well, it 398 00:23:58,480 --> 00:24:02,040 Speaker 1: sounds like they got them. No, I mean they got 399 00:24:02,040 --> 00:24:06,600 Speaker 1: an apology. Yeah, there's now endowed um scholarships and chairs 400 00:24:06,640 --> 00:24:10,359 Speaker 1: at universities around the country in her name. And I 401 00:24:10,400 --> 00:24:12,439 Speaker 1: think if you use HeLa cells now in a study, 402 00:24:12,600 --> 00:24:15,760 Speaker 1: you say, these cells in this use in this study 403 00:24:15,760 --> 00:24:18,200 Speaker 1: were donated by Henrietta Lacks. Yeah, I think that was 404 00:24:18,240 --> 00:24:20,240 Speaker 1: part of the agreement. Yeah, I was talking money though, 405 00:24:20,359 --> 00:24:22,560 Speaker 1: you know, I got you like, they're still poor and 406 00:24:22,600 --> 00:24:24,600 Speaker 1: they still don't have medical coverage. Actually I don't know 407 00:24:24,600 --> 00:24:27,800 Speaker 1: if that's true today, but yeah, yeah, Oh, there's also 408 00:24:27,840 --> 00:24:31,359 Speaker 1: a Henrietta Lacks Foundation too. There is, Uh, you got 409 00:24:31,400 --> 00:24:34,000 Speaker 1: anything else? I got nothing else? All right, Well, if 410 00:24:34,160 --> 00:24:38,080 Speaker 1: you want to learn more about Henrietta Lacks, you should 411 00:24:38,119 --> 00:24:40,719 Speaker 1: probably go read The Immortal Life of Henrietta lacks by 412 00:24:40,720 --> 00:24:44,199 Speaker 1: Rebecca's glute. Sure to check out the website Foundation all 413 00:24:44,240 --> 00:24:47,520 Speaker 1: that Stuff, and you can also go on to how 414 00:24:47,600 --> 00:24:50,200 Speaker 1: stuff works dot com and type henri alas in the 415 00:24:50,240 --> 00:24:52,959 Speaker 1: search par Since I said search parts time for listener, 416 00:24:53,040 --> 00:24:59,480 Speaker 1: maybe right, I'm gonna call this bio diesel dad. Um, Guys, 417 00:24:59,520 --> 00:25:01,680 Speaker 1: after listen a ten easy ways to save money, I 418 00:25:01,720 --> 00:25:03,760 Speaker 1: want to tell you about my dad's super cool garage 419 00:25:03,760 --> 00:25:07,840 Speaker 1: biodiesel LOP. He got into homebrew biodesel about five years 420 00:25:07,840 --> 00:25:10,679 Speaker 1: ago and since developed a very sophisticated setup which can 421 00:25:10,720 --> 00:25:14,000 Speaker 1: produce a ninety gallon batch of biofuel in three to 422 00:25:14,040 --> 00:25:18,080 Speaker 1: five days. UH. The simple rundown is that you filter 423 00:25:18,320 --> 00:25:21,440 Speaker 1: use vegetable oil, boil off the excess water, and lie 424 00:25:21,440 --> 00:25:25,280 Speaker 1: in methanol and filter filter filter. UH. He regularly gathers 425 00:25:25,280 --> 00:25:28,520 Speaker 1: to used vegetable oil from various restaurants and bars around 426 00:25:28,560 --> 00:25:30,879 Speaker 1: town who are happy to give it to him. UH. 427 00:25:31,000 --> 00:25:34,840 Speaker 1: He uses the biodiesel to self sufficiently fuel my mom's SUV, 428 00:25:35,280 --> 00:25:40,320 Speaker 1: his sedan, his truck, and his twenty six ft fishing boat. UH. 429 00:25:40,400 --> 00:25:42,840 Speaker 1: No engine modification is required and can be mixed at 430 00:25:42,840 --> 00:25:47,040 Speaker 1: any ratio with normal petroleum diesel. As far as money 431 00:25:47,040 --> 00:25:49,200 Speaker 1: savings go, the raw chemicals only end up costing about 432 00:25:49,200 --> 00:25:51,560 Speaker 1: a dollar per gallon, so I'll let you do the math. 433 00:25:52,200 --> 00:25:54,480 Speaker 1: While I'm not recommending that everyone go out and build 434 00:25:54,480 --> 00:25:58,239 Speaker 1: their own biodiesel plant in their garage, especially since I'm 435 00:25:58,280 --> 00:26:00,920 Speaker 1: not sure how legal it is a permit, I was 436 00:26:00,920 --> 00:26:03,119 Speaker 1: wondering that too. I thought you guys would find this 437 00:26:03,280 --> 00:26:05,280 Speaker 1: interesting at least. I started listening to the show in 438 00:26:05,320 --> 00:26:08,919 Speaker 1: September during the long drive moving to Stanford where I 439 00:26:08,960 --> 00:26:11,119 Speaker 1: just started work as a grad student. And I've been 440 00:26:11,119 --> 00:26:14,119 Speaker 1: a die hard fan ever since. And that is from Ben. 441 00:26:14,560 --> 00:26:17,880 Speaker 1: Thanks Ben, and Ben's dad dude, I don't know his name, 442 00:26:17,920 --> 00:26:21,040 Speaker 1: but good on you, sir. Yeah, it's pretty cool. French 443 00:26:21,080 --> 00:26:25,719 Speaker 1: fire machine. Yeah uh oh, let's see if your family 444 00:26:25,760 --> 00:26:29,440 Speaker 1: members are doing something pretty interesting, we want to hear 445 00:26:29,440 --> 00:26:31,360 Speaker 1: about it from you. You can tweet to us at 446 00:26:31,440 --> 00:26:33,480 Speaker 1: s Y s K podcast. You can join us on 447 00:26:33,480 --> 00:26:35,879 Speaker 1: Facebook dot com, slash so if you should know, you 448 00:26:35,920 --> 00:26:38,400 Speaker 1: can send us an email to Stuff Podcast at Discovery 449 00:26:38,440 --> 00:26:42,000 Speaker 1: dot com, and you can join us at our website, 450 00:26:42,160 --> 00:26:49,560 Speaker 1: Stuff you Should Know dot com for more on this 451 00:26:49,720 --> 00:26:52,240 Speaker 1: and thousands of other topics. Is it how stuff works? 452 00:26:52,240 --> 00:26:59,680 Speaker 1: Dot com