WEBVTT - What's the deal with fluoride?

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<v Speaker 1>And are you doing any traveling this summer?

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<v Speaker 2>We did some traveling, but now I'm just around around Providence.

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<v Speaker 2>How about you.

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<v Speaker 1>We are headed to Italy shortly. I'm very excited, first

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<v Speaker 1>time I've ever been there. It's a dream, lifelong dream.

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<v Speaker 1>But when my family travels, there's this one thing that happens,

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<v Speaker 1>like a week beforehand, and that, for whatever reason, is

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<v Speaker 1>my children panicking about is it safe to drink the water?

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<v Speaker 1>And I think this started. This is probably my fault

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<v Speaker 1>because we went to Morocco on a family vacation once

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<v Speaker 1>and I was like, oh, I mean, you know, there's

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<v Speaker 1>maybe not the best water. And I bought these like

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<v Speaker 1>life straw water bottles so you could put you know,

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<v Speaker 1>these high tech filtered water bottles, and we all had

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<v Speaker 1>one and they were expensive. And now the kids are

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<v Speaker 1>convinced that water everywhere will kill you. Do you guys

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<v Speaker 1>worry about this at all when you travel?

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<v Speaker 2>No, not in it. So that's not in Europe.

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<v Speaker 1>It's a Wilson neurosis.

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<v Speaker 2>There are places I would not drink the water, but

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<v Speaker 2>I would never carry a water straw thing. You know,

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<v Speaker 2>those are for like when you're in the like in

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<v Speaker 2>the woods and it's like the water is full of

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<v Speaker 2>like those are not for like your europe those are

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<v Speaker 2>not for European vacations.

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<v Speaker 1>It's not fun. It's not when I'm drinking water fresh

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<v Speaker 1>from the alpine streams of Lake Como or whatever. I

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<v Speaker 1>was thinking about this because we're talking about floride today

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<v Speaker 1>and in many parts of the world, not Europe and

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<v Speaker 1>not the United States, but in many parts of the world,

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<v Speaker 1>whether the water is safe to drink is a very

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<v Speaker 1>reasonable question to ask. And there are obviously many millions

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<v Speaker 1>and millions of people living in the world who don't

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<v Speaker 1>have access to clean, safe drinking water. And I was

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<v Speaker 1>thinking about that in sort of the like, we're very

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<v Speaker 1>lucky here in the United States to have a broadly

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<v Speaker 1>safe water system. Not everywhere. Flint, Michigan, I see you,

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<v Speaker 1>it's okay, but like you know, broadly speaking standards in place,

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<v Speaker 1>and yet despite that, we can still have an incredible

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<v Speaker 1>debate about whether the water's poisoning our children.

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<v Speaker 2>I think in a way it's because of that, because

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<v Speaker 2>actually it is only when everything is basically going pretty

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<v Speaker 2>good that you are able to argue about things that

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<v Speaker 2>do not matter at all, or already matter a little

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<v Speaker 2>bit in either direction.

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<v Speaker 1>Will arguing on the margins if there's nothing else that

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<v Speaker 1>summarizes the wellness actually podcast, that is it?

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<v Speaker 2>That is it?

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<v Speaker 1>That is it?

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<v Speaker 2>All right, let's get into it. I'm Emily Aster, I'm

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<v Speaker 2>an economist and a data expert.

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<v Speaker 1>And I'm Perry Wilson, I'm a medical doctor.

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<v Speaker 2>It's Thursday, August thirteenth, twenty twenty six. And this is wellness.

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<v Speaker 1>Actually because you're getting a staggering amount of health and

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<v Speaker 1>wellness information nowadays from every source imaginable, and some of

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<v Speaker 1>it is awesome and some.

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<v Speaker 2>Of it is well actually both Fortunately we are both

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<v Speaker 2>people who know how to read studies, how to parse

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<v Speaker 2>the data, and can tell you what's worth thinking about

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<v Speaker 2>and what you can safely ignore.

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<v Speaker 1>But before we dig in, a note that this podcast

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<v Speaker 1>is for educational purposes and should not be construed as

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<v Speaker 1>medical advice. We don't know your unique situation, so talk

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<v Speaker 1>to your doctor for personal health decisions.

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<v Speaker 2>This week we're asking what's the deal with floride? Harry

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<v Speaker 2>and I will give the official smasher pass, and then

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<v Speaker 2>we'll get to your question of the week. But first,

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<v Speaker 2>let's do the health news roundup after the break.

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<v Speaker 1>And We're back with the health news of the week. Emily.

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<v Speaker 1>We've got some interesting information about this weird flavored vapes decision.

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<v Speaker 1>And for constant listeners of the Wellness Actually podcast, you'll

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<v Speaker 1>recall that in an episode a while back, we were

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<v Speaker 1>talking about the rumor of the impending firing of FDA

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<v Speaker 1>Commissioner Marty McCarey. He was then subsequently fired. That's the

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<v Speaker 1>Wellness Actually curse well described. But we had speculated there

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<v Speaker 1>was weird stuff going on regarding his potential firing and

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<v Speaker 1>flavored vapes. And let me just play you the clip

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<v Speaker 1>from that episode.

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<v Speaker 2>It seems like some of the reportings suggested that part

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<v Speaker 2>of the problem is he has been unwilling to follow

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<v Speaker 2>through on some of the requests of the administration, including

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<v Speaker 2>a request to approve fruit flavored vapes. He didn't want

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<v Speaker 2>to approve fruit flavored vapes because it seemed like they

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<v Speaker 2>would be appealing to children, which seems right to me,

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<v Speaker 2>But the administration wanted fruit flavored vapes and I think

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<v Speaker 2>they have now been approved.

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<v Speaker 1>Yeah, that seems like just not a great idea and

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<v Speaker 1>also like what a weird thing for the White House

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<v Speaker 1>to lobby hair. So Emily new information has come to light,

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<v Speaker 1>and I thought, maybe you could tell us what we

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<v Speaker 1>know now was going on behind the scenes in this

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<v Speaker 1>bizarre decision for the FDA to authorize flavored vape sales.

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<v Speaker 2>So there's a lot more going on here, I think

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<v Speaker 2>than perhaps we initially recognized. Ron Wyden, who's a top

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<v Speaker 2>Democrat on the Finance Committee, has now launched an inquiry.

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<v Speaker 2>That's the favorite thing of the That's what the Senate

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<v Speaker 2>and represent.

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<v Speaker 1>That's what they loved inquiries of Chris.

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<v Speaker 2>They love inquiries. But Kennedy had sent him a letter

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<v Speaker 2>and basically a pro tobacco superpack made a large donation

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<v Speaker 2>to a Trump aligned super pack, about five million dollars.

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<v Speaker 2>Then everyone met, presumably in a smoky room because it's

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<v Speaker 2>the tobacco industry, at mar Largo. And then after that

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<v Speaker 2>Trump called Kennedy, Oz and FDA Commissioner Marty McCarey and

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<v Speaker 2>told them. We don't know what he told them, but

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<v Speaker 2>immediately afterwards the flavored vapes were approved. And so it

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<v Speaker 2>it seems like someone paid for this. That's my that's

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<v Speaker 2>my read. That's with my tin hat on. Someone paid

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<v Speaker 2>for this.

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<v Speaker 1>Yeah, I mean, also I want to point out that

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<v Speaker 1>this was such a strange decision from FDA, which you know,

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<v Speaker 1>and Marty McCarey and RFK Junior, who you know are

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<v Speaker 1>many things, but not really tobacco promoters in any way.

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<v Speaker 1>And flavored vapes, just to say it out loud, make

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<v Speaker 1>vaping easier and more attractive to children. That's the major

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<v Speaker 1>that's the major issue with it. Apparently Marty McCarey at

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<v Speaker 1>FDA had been very resistant to approving flavored vapes. That's

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<v Speaker 1>what we were talking about, and now we know. Nevertheless,

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<v Speaker 1>they were approved, and now we know that I'll make

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<v Speaker 1>one correction. According to Wyden's letter to Kennedy, Trump called

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<v Speaker 1>RFK Junior, memodads and Marty McCarey at the meeting, not

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<v Speaker 1>after the meeting, at the meeting, while the tobacco execs

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<v Speaker 1>were there at mar A Lago. So it certainly feels

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<v Speaker 1>like a, hey, we need to authorize flavored vapes. Don't

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<v Speaker 1>know that for sure, but it does explain a bit

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<v Speaker 1>of a mystery that we were curious about on a

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<v Speaker 1>prior episode.

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<v Speaker 2>Wonderful getting to the bottom of all kinds of things

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<v Speaker 2>and finding the bottom is even worse than.

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<v Speaker 1>One lower than you mentioned.

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<v Speaker 2>All Right, next up, we've got a new executive order

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<v Speaker 2>about vaccines. There's been a lot of discussion about vaccines.

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<v Speaker 2>This is something that OURFA Junior and Trump appear to

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<v Speaker 2>be aligned on their feelings that vaccines aren't their favorite.

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<v Speaker 2>Last winter, RFK Junior tried to introduce a new vaccine

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<v Speaker 2>schedule by just saying what it should be. This is

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<v Speaker 2>not the typical approach that has been struck down by

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<v Speaker 2>the courts, along with many other things that they've tried

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<v Speaker 2>to do. But now Trump has issued an executive order

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<v Speaker 2>that calls for a smaller number of childhood shots, spacing

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<v Speaker 2>them out more, and he's made some comments just going

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<v Speaker 2>to play the clip of his feelings about this.

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<v Speaker 3>At one year, you should have five separate visits for

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<v Speaker 3>vaccines rather than getting them all in the same day.

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<v Speaker 3>And I saw this early on, and I've seen proof

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<v Speaker 3>of it where they have a vaccination that looks like

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<v Speaker 3>the size of a bottle of soda poured into a

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<v Speaker 3>little child's body, and bad things happen in many cases,

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<v Speaker 3>in too many cases, because this is an explosion, This

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<v Speaker 3>is an epidemic.

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<v Speaker 2>All right, Perry, what do you think.

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<v Speaker 1>I know I've said this before, but I don't like

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<v Speaker 1>how people can just say things that aren't true. I know,

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<v Speaker 1>it's like, I'm so naive to think that we should

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<v Speaker 1>expect our public officials or people on Twitter or influencers

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<v Speaker 1>to cite their sources or you know, have a basis

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<v Speaker 1>in fact for what they're saying. It is obviously false

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<v Speaker 1>that babies get a coke bottle worth of injections. They

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<v Speaker 1>get a couple of millimeters, you know, drop volumes. Like,

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<v Speaker 1>I don't know what he's talking about. There's other inconsistencies

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<v Speaker 1>in this executive order. I mean, he says, oh, we

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<v Speaker 1>should split up the MMR vaccine. Okay, first of all,

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<v Speaker 1>there is no company or individual measles and mumps and

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<v Speaker 1>rebella vaccine that does not exist, so someone has to Now,

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<v Speaker 1>I guess make that. He's also calling for kids to

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<v Speaker 1>have five individual pediatrician visits to get these separate vaccines,

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<v Speaker 1>you know, presumably like how difficult is it to access

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<v Speaker 1>healthcare in the country to begin with, and all of

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<v Speaker 1>this language of like, oh, this is giving parent parental choice, right,

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<v Speaker 1>this is like you know, you want the measles but

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<v Speaker 1>not the mumps, and you want the rebella but not

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<v Speaker 1>the measles vaccine. This administration and I don't try to

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<v Speaker 1>get politically here, but when it comes to issues like this,

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<v Speaker 1>it's very clear that they are anti public health. Like

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<v Speaker 1>as a concept, they are incredibly pro individualistic. It's a

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<v Speaker 1>hyper individualistic political movement, which is why there's resistance, you know,

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<v Speaker 1>to any kind of top down like here's the vaccine schedule.

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<v Speaker 1>Everything should be. You know, you can do what you want,

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<v Speaker 1>you can do what you want, you can do what

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<v Speaker 1>you want. But the central thesis of public health is

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<v Speaker 1>that there are certain things that we kind of have

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<v Speaker 1>to do broadly because if we don't, it doesn't work.

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<v Speaker 1>And it's not just vaccines, it's you know, it's adding

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<v Speaker 1>iodine to salt. It's like all of this stuff that

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<v Speaker 1>has changed the landscape of diseases over the century, and

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<v Speaker 1>it's like getting thrown away. It's very frustrating.

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<v Speaker 2>Sorry, it's very frustrating. But I actually think there's a

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<v Speaker 2>there's another piece of this for me, as someone who

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<v Speaker 2>spends all their time talking to parents, which is that

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<v Speaker 2>it's not that parents come away with this feeling empowered

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<v Speaker 2>and like, you know, now I can choose which vaccines

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<v Speaker 2>I get. You know, people come away feeling confused.

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<v Speaker 1>Yeah, they're confused.

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<v Speaker 2>And they don't actually want by and large, the responsibility

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<v Speaker 2>of evaluating what is the set of vaccines that are

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<v Speaker 2>that I need. People have other stuff to do. That

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<v Speaker 2>is why we have expertise for evaluating which vaccines are

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<v Speaker 2>safe and recommended based on a trade off of costs

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<v Speaker 2>and benefits to those vaccines, and that is why we

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<v Speaker 2>came up with an original vaccine schedule.

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<v Speaker 1>It's a very frustrating situation. It's frustrating. I just also

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<v Speaker 1>want to say there's no new data, like, like we're

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<v Speaker 1>data people. It's one thing. If it's like, oh no,

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<v Speaker 1>we find we did this big study and now there's

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<v Speaker 1>a we have to change things, that's at least then

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<v Speaker 1>we can evaluate. There's nothing new here. There is no

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<v Speaker 1>sign of danger neuro developmentally from the current vaccine schedule.

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<v Speaker 1>There's no evidence that combining measles, mumps, and REBLA versus

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<v Speaker 1>separating it makes any difference in childhood outcomes. There's it's

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<v Speaker 1>it's it's nothing. It's just the whims of the administration

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<v Speaker 1>as far as I can tell.

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<v Speaker 2>Yeah, and it'll hurt kids, which is not it'll hurt

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<v Speaker 2>kids kids, which is all right, I.

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<v Speaker 1>Gotta I gotta calm down. So the the thing that's

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<v Speaker 1>going to calm me down is Emily. You can tell

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<v Speaker 1>me why the Tour de France is gonna outlaw padded brass.

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<v Speaker 2>It's much better than that, So okay. The Tour de

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<v Speaker 2>France is a bicycle race, and there is a female

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<v Speaker 2>Tour de France. It's called the Tour de France femsa

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<v Speaker 2>vex Wick.

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<v Speaker 1>It's this.

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<v Speaker 2>Wick is a SoC company, I believe, and they sponsor

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<v Speaker 2>this race. So you have to say the whole.

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<v Speaker 1>Name big big sock, big sock.

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<v Speaker 2>Big sock. They're in bed with big sock. But an

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<v Speaker 2>issue that they're having is that apparently, when you are

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<v Speaker 2>biking in a time trial, it's very important to be aerodynamic,

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<v Speaker 2>and one of the things that enhances your aerodynamicness is

0:12:45.920 --> 0:12:49.480
<v Speaker 2>to have like more bulk on your front. I have

0:12:49.520 --> 0:12:51.319
<v Speaker 2>no idea why this would be. I don't know enough

0:12:51.360 --> 0:12:55.400
<v Speaker 2>about cycling, but you like it's like otherwise, Actually it's

0:12:55.440 --> 0:12:57.520
<v Speaker 2>like otherwise, it's more like a sale. I think it's

0:12:57.559 --> 0:13:01.199
<v Speaker 2>a bit like for listeners of our very first episode,

0:13:01.200 --> 0:13:03.160
<v Speaker 2>it's a bit like the penis the penis thing and

0:13:03.200 --> 0:13:05.720
<v Speaker 2>the ski jumpers I think, but like the opposite.

0:13:05.920 --> 0:13:08.760
<v Speaker 1>You need a padded penis to fly further in a.

0:13:08.840 --> 0:13:13.000
<v Speaker 2>Ski jump anyway, So people there's an intentive to like

0:13:13.040 --> 0:13:16.440
<v Speaker 2>bulk yourself up. And apparently there's an accusation that some

0:13:16.600 --> 0:13:19.320
<v Speaker 2>of the riders in the Twitter Fronts fems were wearing

0:13:19.320 --> 0:13:22.760
<v Speaker 2>bras that were too large, possibly padded. I don't think stuffed,

0:13:22.800 --> 0:13:24.920
<v Speaker 2>but like you know, instead of wearing a B cup,

0:13:24.920 --> 0:13:26.560
<v Speaker 2>you put like on a D cup raw and like

0:13:26.600 --> 0:13:29.359
<v Speaker 2>the padding is in there to make themselves more aerodynamic.

0:13:29.640 --> 0:13:31.400
<v Speaker 2>So then people were saying, Okay, we're going to have

0:13:31.400 --> 0:13:34.040
<v Speaker 2>somebody check like when before you get on, someone's going

0:13:34.120 --> 0:13:36.080
<v Speaker 2>to like check out make sure your BRA's not too big.

0:13:36.200 --> 0:13:38.440
<v Speaker 2>But then other people felt like, hey, we need an

0:13:38.480 --> 0:13:41.880
<v Speaker 2>elderly Frenchman checking the bras of all the female cyclists.

0:13:41.920 --> 0:13:44.640
<v Speaker 2>That seems a little awkward. So we've sort of it

0:13:44.840 --> 0:13:46.320
<v Speaker 2>kind of died died there.

0:13:47.440 --> 0:13:51.480
<v Speaker 1>Yeah, it probably should die there, so light but it is.

0:13:51.720 --> 0:13:54.360
<v Speaker 2>It's But I like this because it's an example of

0:13:54.480 --> 0:13:58.200
<v Speaker 2>like what of the sort of almost like wellness, like

0:13:58.240 --> 0:14:00.400
<v Speaker 2>what's too far right? If you're at the point where

0:14:00.440 --> 0:14:02.040
<v Speaker 2>you're like, I'm going to put a really big brod

0:14:02.120 --> 0:14:05.319
<v Speaker 2>to go faster, like it's you're taking it too far.

0:14:05.520 --> 0:14:08.520
<v Speaker 1>I hot take. I think actually a lot of this stuff,

0:14:08.559 --> 0:14:11.280
<v Speaker 1>including some of the band supplements and things like that,

0:14:11.720 --> 0:14:15.520
<v Speaker 1>actually don't make any difference, and it's just sort of

0:14:16.040 --> 0:14:16.920
<v Speaker 1>you know, they're like.

0:14:17.240 --> 0:14:18.160
<v Speaker 2>All on your head anyway.

0:14:18.160 --> 0:14:20.520
<v Speaker 1>Maybe it's like a cautionarily banning things.

0:14:20.600 --> 0:14:21.960
<v Speaker 2>Yeah, or you put on your big bron then you

0:14:22.000 --> 0:14:23.920
<v Speaker 2>feel like, ah, now I've got my big broad, like

0:14:23.960 --> 0:14:26.320
<v Speaker 2>I'm going to go super fast and my cool T

0:14:26.480 --> 0:14:26.920
<v Speaker 2>T bike.

0:14:27.680 --> 0:14:29.520
<v Speaker 1>Well, I sure I'm going to put on a big

0:14:29.520 --> 0:14:33.200
<v Speaker 1>broad next time I go totally big boob energy. All right,

0:14:33.480 --> 0:14:36.320
<v Speaker 1>that's it for the health news of the week. What's

0:14:36.400 --> 0:14:42.400
<v Speaker 1>the deal with fluoride? Oh boy, Emily, this is a

0:14:42.440 --> 0:14:45.880
<v Speaker 1>controversial topic. We're gonna make some.

0:14:45.800 --> 0:14:50.120
<v Speaker 2>People mad for for some for a you know, for

0:14:50.200 --> 0:14:55.280
<v Speaker 2>a thing that is about municipal water supplies. I can't

0:14:55.360 --> 0:14:59.400
<v Speaker 2>believe how much people care, you know, Like did you

0:14:59.480 --> 0:15:01.240
<v Speaker 2>have on your and go card? People would be like,

0:15:01.360 --> 0:15:04.440
<v Speaker 2>I really want to discuss the details of our municipal

0:15:04.480 --> 0:15:05.040
<v Speaker 2>water supply.

0:15:05.280 --> 0:15:08.200
<v Speaker 1>I mean I think they care because of the classic like,

0:15:08.280 --> 0:15:10.760
<v Speaker 1>but what about the children? Right, Like if you can

0:15:10.800 --> 0:15:14.760
<v Speaker 1>attach any whatever your issue is, like attach it to

0:15:14.760 --> 0:15:18.320
<v Speaker 1>the children like it's going to do better. This is

0:15:18.360 --> 0:15:23.400
<v Speaker 1>not new concerns about fluoride. And I've got to play

0:15:23.440 --> 0:15:27.440
<v Speaker 1>you just brilliant clip from Doctor Strangelove.

0:15:28.320 --> 0:15:33.120
<v Speaker 4>Water. That's what I'm getting at water and as human beings,

0:15:33.880 --> 0:15:37.920
<v Speaker 4>you and I need fresh, pure water to replenish our

0:15:37.960 --> 0:15:44.120
<v Speaker 4>precious bodily fluids. Mandrake. Have you never wondered why I

0:15:44.240 --> 0:15:47.840
<v Speaker 4>drink only to stilled water or rain water and only

0:15:47.960 --> 0:15:51.320
<v Speaker 4>pure grain alcohol. Have you ever heard of a thing

0:15:51.360 --> 0:15:57.040
<v Speaker 4>called floridation? Floridation of water? H Yes, I have heard

0:15:57.080 --> 0:16:00.160
<v Speaker 4>of that, Jack, Yes, yes, Whether you know what it is,

0:16:00.760 --> 0:16:07.280
<v Speaker 4>do you realize that floridation is the most monstrously conceived

0:16:07.760 --> 0:16:10.400
<v Speaker 4>and dangerous communist plot we have ever had to face.

0:16:10.840 --> 0:16:17.160
<v Speaker 1>That was Peter Sellers and Sterling Hayden playing General Jack

0:16:17.240 --> 0:16:21.400
<v Speaker 1>d Ripper from Doctor Strangelove. Do yourself a favor if

0:16:21.440 --> 0:16:23.880
<v Speaker 1>you haven't seen it, and see it. It is absolutely

0:16:23.960 --> 0:16:28.280
<v Speaker 1>hilarious and dark and wonderful. Jackie Ripper essentially starts a

0:16:28.320 --> 0:16:31.480
<v Speaker 1>nuclear war because he's paranoid about fluoridation of the water supply.

0:16:31.560 --> 0:16:33.600
<v Speaker 1>So this has been going on for a long time.

0:16:33.600 --> 0:16:37.880
<v Speaker 1>This is not a new theory or conspiracy theory. And

0:16:38.760 --> 0:16:41.600
<v Speaker 1>you know, we need to sort of dig in I

0:16:41.640 --> 0:16:45.360
<v Speaker 1>think broadly speaking to why it's there in the first place,

0:16:45.960 --> 0:16:47.520
<v Speaker 1>and then maybe the concerns about it.

0:16:48.040 --> 0:16:50.480
<v Speaker 2>Yeah, I think it's worth like, let's just start with

0:16:50.760 --> 0:16:54.360
<v Speaker 2>you know, your municipal water supply. It is not just

0:16:54.600 --> 0:16:57.320
<v Speaker 2>beautiful alpine spring water like you will be drinking on

0:16:57.360 --> 0:17:01.440
<v Speaker 2>your vacation. There are many many things that we add

0:17:01.640 --> 0:17:02.880
<v Speaker 2>to water.

0:17:03.320 --> 0:17:06.520
<v Speaker 1>Yeah, I am really acutely aware of this because I'm

0:17:06.520 --> 0:17:12.560
<v Speaker 1>a nephrologist, and nephrologists do dialysis where you run blood

0:17:12.560 --> 0:17:15.760
<v Speaker 1>through a machine and it cleans the blood, and the

0:17:15.800 --> 0:17:18.159
<v Speaker 1>water that runs on the outside of the dialysis membrane

0:17:18.200 --> 0:17:20.600
<v Speaker 1>generally comes from municipal water supplies, and we have to

0:17:20.640 --> 0:17:23.720
<v Speaker 1>be very concerned because anything in that water supply can

0:17:23.800 --> 0:17:26.240
<v Speaker 1>get through the dialysis membrane into the blood. So we

0:17:26.280 --> 0:17:28.679
<v Speaker 1>get very panicked about stuff, and we do a lot

0:17:28.760 --> 0:17:31.119
<v Speaker 1>of things to treat the water supply before we use

0:17:31.160 --> 0:17:33.760
<v Speaker 1>it on a dialysis patient. So a brief list of

0:17:33.800 --> 0:17:39.040
<v Speaker 1>things that are in your water aside from chluoride, chlorine, monochloramine,

0:17:39.119 --> 0:17:41.800
<v Speaker 1>chlorine dioxide, those are all to kill bacteria. People don't

0:17:41.800 --> 0:17:46.240
<v Speaker 1>complain about chlorination of water very often orthophosphates and polyphosphates

0:17:46.280 --> 0:17:49.960
<v Speaker 1>to prevent pipe corrosion, Sodium hydroxide and acidic water, sulfuric

0:17:50.000 --> 0:17:52.000
<v Speaker 1>acid and alkaline water. You got to get the pH right.

0:17:52.280 --> 0:17:55.040
<v Speaker 1>Aluminum sulfate as a flocculant to get all the little

0:17:55.080 --> 0:17:58.520
<v Speaker 1>pieces of dirt and things to precipitate out, Potassium permagonate

0:17:58.800 --> 0:18:02.080
<v Speaker 1>to precipitate out iron oxides so you don't get rust

0:18:02.240 --> 0:18:06.119
<v Speaker 1>colored water. So there is a lot and nobody is

0:18:06.160 --> 0:18:10.160
<v Speaker 1>going to town halls demanding that we no longer chlorinate

0:18:10.200 --> 0:18:14.080
<v Speaker 1>the water supply because if we stopped doing that, everyone

0:18:14.119 --> 0:18:16.119
<v Speaker 1>would get back toial infections and die.

0:18:16.320 --> 0:18:20.480
<v Speaker 2>Yeah. I think what does differentiate fluoride from these other

0:18:20.760 --> 0:18:25.879
<v Speaker 2>things is that fluoride is not there to clean the

0:18:25.960 --> 0:18:29.600
<v Speaker 2>water and to make it so you don't get poop

0:18:29.680 --> 0:18:33.080
<v Speaker 2>diseases from it. It is added because we think it

0:18:33.119 --> 0:18:36.119
<v Speaker 2>is good for people's teeth. Basically, can't get more into that,

0:18:36.160 --> 0:18:37.920
<v Speaker 2>but it's added as a kind of this is something

0:18:37.960 --> 0:18:41.359
<v Speaker 2>to benefit you, as opposed to without this, your water

0:18:41.440 --> 0:18:42.359
<v Speaker 2>will make you ill.

0:18:42.640 --> 0:18:44.120
<v Speaker 1>Yes, that's a great distinction.

0:18:44.520 --> 0:18:47.720
<v Speaker 2>It seems more optional. No one is interested in fighting

0:18:47.760 --> 0:18:50.760
<v Speaker 2>about chlorine because if you took that out we'd all

0:18:50.760 --> 0:18:51.320
<v Speaker 2>be really sick.

0:18:51.640 --> 0:18:55.320
<v Speaker 1>It seems more optional. And also there's the psychological like

0:18:55.600 --> 0:18:59.359
<v Speaker 1>something is being done to me even though you're ingesting

0:18:59.359 --> 0:19:02.479
<v Speaker 1>the chlorine from the water and the potassium promagnate from

0:19:02.520 --> 0:19:04.960
<v Speaker 1>the water. Like the intention isn't there, I think, is

0:19:04.960 --> 0:19:07.080
<v Speaker 1>what you're saying. And there's something about the intentionality of

0:19:07.119 --> 0:19:09.560
<v Speaker 1>fluoride that gets people's hackles up more.

0:19:10.160 --> 0:19:13.119
<v Speaker 2>Yeah, that's my feeling. Although it's hard to get inside

0:19:13.119 --> 0:19:15.439
<v Speaker 2>people's it's hard to get inside people's head. And you know,

0:19:15.520 --> 0:19:21.240
<v Speaker 2>could we generate a bunch of panic about something called orthophosphate?

0:19:21.280 --> 0:19:24.480
<v Speaker 2>Like probably that doesn't sound good, so maybe that would

0:19:24.480 --> 0:19:26.360
<v Speaker 2>be our next episode.

0:19:26.800 --> 0:19:28.640
<v Speaker 1>What about their children being supposed to work?

0:19:28.720 --> 0:19:32.200
<v Speaker 2>About the children and the pipe corrosion or whatever. Okay,

0:19:32.280 --> 0:19:35.879
<v Speaker 2>so before we get into the details of this, let's

0:19:35.880 --> 0:19:42.359
<v Speaker 2>talk about why we how we know that fluoride is

0:19:42.400 --> 0:19:44.840
<v Speaker 2>good and where this initially came from.

0:19:45.119 --> 0:19:49.440
<v Speaker 1>It's such an interesting story. So the history of fluoride

0:19:49.880 --> 0:19:52.840
<v Speaker 1>in medicine goes back to nineteen oh one and doctor

0:19:52.880 --> 0:19:57.439
<v Speaker 1>Frederick McKay who was looking at a condition which was

0:19:57.960 --> 0:20:02.160
<v Speaker 1>called Colorado brown stain from Colorado Springs, Colorado. These were

0:20:02.160 --> 0:20:05.199
<v Speaker 1>people that had brown stains on their teeth, but McKay

0:20:05.200 --> 0:20:07.720
<v Speaker 1>made the insight that they actually had a really low

0:20:07.800 --> 0:20:09.840
<v Speaker 1>rate of cavities, Like the teeth kind of were ugly

0:20:09.880 --> 0:20:11.399
<v Speaker 1>and had these brown stains on it, but they just

0:20:11.440 --> 0:20:14.919
<v Speaker 1>didn't get cavities. It was not entirely clear what was

0:20:14.920 --> 0:20:19.040
<v Speaker 1>protecting them until nineteen thirty one when HV. Churchill out

0:20:19.080 --> 0:20:23.119
<v Speaker 1>at Alcoa used spectrographic analysis to determine what was in

0:20:23.160 --> 0:20:27.440
<v Speaker 1>the water at Colorado Springs and discovered it was fluoride,

0:20:27.480 --> 0:20:31.640
<v Speaker 1>and the levels of naturally accurring fluoride there were very,

0:20:31.760 --> 0:20:35.040
<v Speaker 1>very high, about thirteen point two parts per million in

0:20:35.119 --> 0:20:39.399
<v Speaker 1>the brown stain affected areas. We're going to talk a

0:20:39.400 --> 0:20:41.480
<v Speaker 1>lot about like the dosage of floride in the water,

0:20:41.560 --> 0:20:43.840
<v Speaker 1>so it might be worth just like let's just set

0:20:44.320 --> 0:20:47.480
<v Speaker 1>the stage now and I'll try to give round numbers,

0:20:47.520 --> 0:20:51.480
<v Speaker 1>but like ten parts per million the sort of Colorado

0:20:51.480 --> 0:20:57.320
<v Speaker 1>brown stain is a lot. The target in floridated water

0:20:57.640 --> 0:21:00.840
<v Speaker 1>is zero point seven parts per million, like a tenth

0:21:00.840 --> 0:21:03.159
<v Speaker 1>of that. And one of the key insights is that

0:21:03.200 --> 0:21:06.720
<v Speaker 1>floride will protect teeth without causing stains at low doses,

0:21:06.840 --> 0:21:09.359
<v Speaker 1>and then it can sort of cause white stains fluorosis

0:21:09.400 --> 0:21:11.480
<v Speaker 1>at about three to four parts per million and then

0:21:11.800 --> 0:21:15.200
<v Speaker 1>like really excessive fluoride can cause these brown stains once

0:21:15.240 --> 0:21:17.720
<v Speaker 1>you get up to like ten parts per million or so. Okay,

0:21:18.080 --> 0:21:21.560
<v Speaker 1>So in nineteen forty one forty two, that's when they

0:21:21.600 --> 0:21:23.720
<v Speaker 1>sort of did the dose finding study to figure out

0:21:23.720 --> 0:21:26.680
<v Speaker 1>that low doses of fluoride would be protective of teeth.

0:21:26.720 --> 0:21:29.800
<v Speaker 1>And then nineteen forty five the first community water fluoridation

0:21:29.920 --> 0:21:32.600
<v Speaker 1>happened in Grand Rapids, Michigan. At lest I.

0:21:32.600 --> 0:21:34.520
<v Speaker 2>Don't just want to pause, I want to pause you

0:21:34.600 --> 0:21:38.040
<v Speaker 2>on the because I think one one thing that's worth saying, well,

0:21:38.080 --> 0:21:39.920
<v Speaker 2>how did you know? How do they know about the

0:21:40.040 --> 0:21:43.320
<v Speaker 2>dosing here? And the answer is that there is a

0:21:43.320 --> 0:21:46.440
<v Speaker 2>fair amount of naturally occurring variation and how much fluoride

0:21:46.440 --> 0:21:49.880
<v Speaker 2>there is in US water across space. There are parts

0:21:49.920 --> 0:21:52.360
<v Speaker 2>of the world China, India where actually the fluoride levels

0:21:52.400 --> 0:21:55.160
<v Speaker 2>and water are very high. Obviously Colorado Springs is very high.

0:21:55.160 --> 0:21:59.200
<v Speaker 2>There's also variation in other places. So many people live

0:21:59.240 --> 0:22:01.919
<v Speaker 2>in areas where they naturally occurring water fluoride in the

0:22:01.920 --> 0:22:05.640
<v Speaker 2>water is higher. They use that to figure out basically

0:22:05.680 --> 0:22:08.240
<v Speaker 2>how that relates to teeth health.

0:22:08.480 --> 0:22:11.600
<v Speaker 1>It's such a good point, and when community water fluoridation happens,

0:22:11.640 --> 0:22:15.320
<v Speaker 1>they're they're not adding just like a random amount, they're

0:22:15.400 --> 0:22:18.520
<v Speaker 1>getting the level up to zero point seven. Basically, nineteen

0:22:18.560 --> 0:22:21.720
<v Speaker 1>forty five, Grand Rapids, Michigan is the first community water

0:22:21.720 --> 0:22:23.879
<v Speaker 1>fluoridation at one part per million, a little higher than

0:22:23.880 --> 0:22:28.480
<v Speaker 1>we do today. Muskegan was sort of a control community nearby,

0:22:29.080 --> 0:22:32.320
<v Speaker 1>and compared to Miskegan, cavities went down by fifty percent

0:22:32.640 --> 0:22:35.239
<v Speaker 1>in Grand Rapids, Michigan over the next fifteen years, so

0:22:35.440 --> 0:22:39.920
<v Speaker 1>pretty effective public health intervention. It was nineteen fifty when

0:22:39.960 --> 0:22:44.440
<v Speaker 1>the United States Public Health Service endorsed fluoridation. Remember when

0:22:44.440 --> 0:22:45.919
<v Speaker 1>we used to have a public health service.

0:22:46.280 --> 0:22:47.640
<v Speaker 2>I still have it.

0:22:47.960 --> 0:22:51.960
<v Speaker 1>And nineteen fifty five when the first fluoride toothpaste was

0:22:52.040 --> 0:22:54.680
<v Speaker 1>introduced to the market. Do you know what brand got

0:22:54.720 --> 0:23:00.679
<v Speaker 1>there first? Crest Crest Crest Toothpaste. By nineteen seventy, floride

0:23:00.680 --> 0:23:05.560
<v Speaker 1>toothpaste was sort of everywhere. The more interesting history is

0:23:05.640 --> 0:23:12.399
<v Speaker 1>probably recent. So in twenty twenty four, a federal court

0:23:12.680 --> 0:23:17.800
<v Speaker 1>found quote unreasonable risk of fluoridation under the Toxic Substances

0:23:17.880 --> 0:23:22.720
<v Speaker 1>Control Act and ordered epa action. That ruling was subsequently

0:23:22.840 --> 0:23:26.200
<v Speaker 1>vacated by a higher court, but in the interim, both

0:23:26.200 --> 0:23:31.240
<v Speaker 1>Florida and Utah enacted statewide fluoridation bands in twenty twenty five.

0:23:31.400 --> 0:23:34.440
<v Speaker 1>And so what you see over the past century and

0:23:34.600 --> 0:23:40.040
<v Speaker 1>plus is a burgeoning understanding of the protective power of fluoride,

0:23:40.200 --> 0:23:44.399
<v Speaker 1>a broad public scale adoption, and a much more recent

0:23:44.480 --> 0:23:48.160
<v Speaker 1>backlash and sort of reducing of florid.

0:23:48.760 --> 0:23:51.240
<v Speaker 2>Yeah, and I think in the current moment, it's kind

0:23:51.240 --> 0:23:57.200
<v Speaker 2>of hard to overstate how much anxiety people have about

0:23:57.200 --> 0:24:00.160
<v Speaker 2>this and how much you hear about this on cert

0:24:00.320 --> 0:24:04.000
<v Speaker 2>corners of the internet. You know, it's it does have

0:24:04.080 --> 0:24:06.800
<v Speaker 2>the flavor of you know, they're adding the water to fluoride,

0:24:06.840 --> 0:24:09.240
<v Speaker 2>to the water to poison us, and also just the

0:24:09.320 --> 0:24:12.040
<v Speaker 2>general flavor of like this is something to be very

0:24:12.040 --> 0:24:15.480
<v Speaker 2>worried about, like your children may be damaged by this

0:24:16.000 --> 0:24:20.600
<v Speaker 2>fluoridated water in some very meaningful way, and people are afraid.

0:24:20.920 --> 0:24:24.520
<v Speaker 2>And that is then what drives some of these court decisions.

0:24:24.800 --> 0:24:27.680
<v Speaker 1>It absolutely is what drives I mean, I don't know

0:24:27.760 --> 0:24:30.000
<v Speaker 1>one's saying like we love cavities, this is this is

0:24:30.080 --> 0:24:32.080
<v Speaker 1>all about nerd development and IQ.

0:24:32.320 --> 0:24:34.320
<v Speaker 2>And you know, it's a place where you can put

0:24:34.720 --> 0:24:37.840
<v Speaker 2>photos that totally freak people out. So like fluoride is

0:24:37.880 --> 0:24:41.760
<v Speaker 2>added to your municipal water by adding small amounts of

0:24:42.119 --> 0:24:45.399
<v Speaker 2>I don't know, it's a mineral, so like rock crushed

0:24:45.440 --> 0:24:48.040
<v Speaker 2>up rock, mineral fluoride rocks they cut and they come

0:24:48.080 --> 0:24:51.240
<v Speaker 2>in bags, and you can't just like eat bags of fluoride.

0:24:51.280 --> 0:24:54.159
<v Speaker 2>You know, they're dangerous. It's a dangerous toxic chemical at

0:24:54.240 --> 0:24:57.680
<v Speaker 2>high doses. And so those bags have you know, skull

0:24:57.720 --> 0:24:59.879
<v Speaker 2>and crossbones on them or whatever is marked for poisoned

0:24:59.880 --> 0:25:01.879
<v Speaker 2>the but like, look at this, they're adding poison to

0:25:01.920 --> 0:25:02.240
<v Speaker 2>your water.

0:25:02.359 --> 0:25:06.560
<v Speaker 1>It's like, well, like, yeah, so does the potentia manganate

0:25:06.640 --> 0:25:07.240
<v Speaker 1>and the chlorin.

0:25:07.359 --> 0:25:11.000
<v Speaker 2>Yeah, exactly, Like don't don't eat that out of the bag.

0:25:12.000 --> 0:25:13.040
<v Speaker 1>Uh, not a.

0:25:13.000 --> 0:25:14.040
<v Speaker 2>Nerds mummy cluster.

0:25:14.200 --> 0:25:17.560
<v Speaker 1>That is a disingenuous argument, but you know, I think.

0:25:17.400 --> 0:25:19.960
<v Speaker 2>It's not a very very compelling one, very compelling.

0:25:20.280 --> 0:25:23.640
<v Speaker 1>Yeah, the dose makes the poisons, as the toxicologists will

0:25:23.640 --> 0:25:25.720
<v Speaker 1>tell you. And we're going to get to the IQ studies,

0:25:25.760 --> 0:25:28.240
<v Speaker 1>Like I think it's important that we actually go through

0:25:28.280 --> 0:25:30.359
<v Speaker 1>them with a little more depth than here's a picture

0:25:30.400 --> 0:25:32.320
<v Speaker 1>of the big bag of floride with a skung cross

0:25:32.320 --> 0:25:32.840
<v Speaker 1>bones on it.

0:25:33.200 --> 0:25:35.520
<v Speaker 2>But first, because we love science so much, I think

0:25:35.640 --> 0:25:37.840
<v Speaker 2>I always want to leave people out of these with

0:25:38.240 --> 0:25:41.080
<v Speaker 2>an understanding of like how science is cool, and if

0:25:41.119 --> 0:25:43.960
<v Speaker 2>you understand the science, you can't appreciate why you would

0:25:44.000 --> 0:25:50.560
<v Speaker 2>do something. So fluoride helps your teeth by improving the

0:25:50.760 --> 0:25:52.840
<v Speaker 2>enamel basically.

0:25:52.560 --> 0:25:57.080
<v Speaker 1>Mm hmm, it's really fascinating. So enamel, which is the

0:25:57.200 --> 0:26:00.120
<v Speaker 1>protective covering on your teeth, has a crystal in it,

0:26:00.200 --> 0:26:05.600
<v Speaker 1>a crystal structure called hydroxy appetite, and fluoride integrates into

0:26:05.600 --> 0:26:11.240
<v Speaker 1>the hydroxy appetite crystal just through regular chemistry that makes

0:26:11.280 --> 0:26:14.840
<v Speaker 1>it fluoro appetite when the fluoride is integrated there, and

0:26:14.920 --> 0:26:18.600
<v Speaker 1>fluoro appetite is a little denser than hydroxy appetite, it's

0:26:19.119 --> 0:26:23.720
<v Speaker 1>less soluble. But the critical part is that enamel can

0:26:23.760 --> 0:26:26.720
<v Speaker 1>dissolve at a low pH anyone ever dissolve a tooth

0:26:26.920 --> 0:26:29.680
<v Speaker 1>in coke for science Fair project?

0:26:29.840 --> 0:26:33.119
<v Speaker 2>Yep, but I totally could. Because my son apparently is

0:26:33.119 --> 0:26:35.280
<v Speaker 2>saving all of his teeth in a small container that

0:26:35.320 --> 0:26:36.800
<v Speaker 2>I found the other day because he's a white sleep

0:26:36.800 --> 0:26:38.520
<v Speaker 2>away camp. There's just like a little container in his

0:26:38.560 --> 0:26:40.080
<v Speaker 2>bathroom of all of his baby teeth.

0:26:40.440 --> 0:26:41.720
<v Speaker 1>Oh, he's saving his teeth.

0:26:42.040 --> 0:26:44.440
<v Speaker 2>Yeah, yeah, I don't even know where, Like I thought

0:26:44.440 --> 0:26:45.960
<v Speaker 2>I was supposed to take them, but we moved away

0:26:45.960 --> 0:26:47.680
<v Speaker 2>from the tooth fairy when he figured out it wasn't real,

0:26:47.720 --> 0:26:50.840
<v Speaker 2>I just venmo him and so I guess he's keeping

0:26:50.840 --> 0:26:51.639
<v Speaker 2>the teeth. I don't know.

0:26:51.680 --> 0:26:52.680
<v Speaker 1>I love it, do you?

0:26:52.880 --> 0:26:52.960
<v Speaker 4>Do?

0:26:52.960 --> 0:26:56.440
<v Speaker 1>You use the fairy emoji? Though? I?

0:26:56.920 --> 0:26:58.600
<v Speaker 2>I just sometimes I leave him a note that's like

0:26:58.640 --> 0:27:00.440
<v Speaker 2>I added some money to your oh my goods.

0:27:02.080 --> 0:27:07.359
<v Speaker 1>So yeah, so enamel. Enamel dissolves at a low pH

0:27:07.880 --> 0:27:12.520
<v Speaker 1>and bacteria in your mouth release acid, and after you

0:27:12.600 --> 0:27:15.440
<v Speaker 1>eat and the bacteria started growing and stuff like that,

0:27:15.480 --> 0:27:18.800
<v Speaker 1>the pH gets around to five in your mouth. Now,

0:27:19.240 --> 0:27:25.480
<v Speaker 1>hydroxy appetite will start to dissolve around five point five pH,

0:27:26.240 --> 0:27:31.119
<v Speaker 1>but fluoro appetite doesn't start to dissolve until a pH

0:27:31.160 --> 0:27:34.200
<v Speaker 1>of about four point five. So that's one pH unit.

0:27:34.240 --> 0:27:37.280
<v Speaker 1>That's actually a tenfold difference in acid concentration because it's

0:27:37.280 --> 0:27:39.880
<v Speaker 1>a log scale, so it makes it much more resistant

0:27:39.880 --> 0:27:43.120
<v Speaker 1>to acid. There's also some thought that there's some antibacterial

0:27:43.200 --> 0:27:45.960
<v Speaker 1>properties of fluoride as well, but bottom line, this is

0:27:46.080 --> 0:27:50.560
<v Speaker 1>well described. We know how this works, so the question

0:27:50.800 --> 0:27:54.240
<v Speaker 1>is no longer like, does fluoride truly protect teeth? Like

0:27:54.760 --> 0:27:57.440
<v Speaker 1>we know it does. The question, and I think the

0:27:57.560 --> 0:28:02.199
<v Speaker 1>question more people have now is Okay, I believe you

0:28:02.240 --> 0:28:05.840
<v Speaker 1>that in nineteen forty five, maybe it was important to

0:28:05.880 --> 0:28:08.240
<v Speaker 1>add fluoride to the water because that was the only

0:28:08.240 --> 0:28:11.199
<v Speaker 1>way people were getting fluoride and et cetera. But now

0:28:11.240 --> 0:28:14.960
<v Speaker 1>we have crest and other forms of toothpaste, and so

0:28:15.680 --> 0:28:18.080
<v Speaker 1>you know, do we still need to be fluoridating the

0:28:18.080 --> 0:28:19.160
<v Speaker 1>water supply? Yeah?

0:28:19.240 --> 0:28:23.040
<v Speaker 2>I think this is I think genuinely an interesting question

0:28:23.240 --> 0:28:26.639
<v Speaker 2>because of course an intervention like dumping fluoride into the

0:28:26.640 --> 0:28:30.679
<v Speaker 2>water supply is in some very very effective, but in

0:28:30.680 --> 0:28:34.239
<v Speaker 2>some ways of somewhat coarse intervention, and over time you

0:28:34.280 --> 0:28:37.359
<v Speaker 2>could imagine saying, you know, well everybody's got fluoride in

0:28:37.400 --> 0:28:40.400
<v Speaker 2>their toothpaste now, and so we don't need to be

0:28:40.520 --> 0:28:46.320
<v Speaker 2>using this other mechanism. And if there's no purpose in this,

0:28:46.360 --> 0:28:47.960
<v Speaker 2>then we shouldn't be doing it, which of course is

0:28:48.560 --> 0:28:49.560
<v Speaker 2>generally true.

0:28:49.800 --> 0:28:50.040
<v Speaker 4>For me.

0:28:50.160 --> 0:28:53.360
<v Speaker 2>This is an interesting skeptical skeptical case. It's probably the

0:28:53.360 --> 0:28:55.960
<v Speaker 2>most interesting of the skeptical cases. You know, not so

0:28:56.040 --> 0:28:57.400
<v Speaker 2>much is this harmful.

0:28:56.960 --> 0:28:58.760
<v Speaker 1>But literally just is it it's doing it?

0:28:58.880 --> 0:29:03.640
<v Speaker 2>Is it necessary? And I think the honest answer hearing

0:29:03.800 --> 0:29:05.959
<v Speaker 2>go through some studies, I think that the honest answer

0:29:06.200 --> 0:29:11.200
<v Speaker 2>is there is not an air tight case as air

0:29:11.240 --> 0:29:14.680
<v Speaker 2>tight a case now as there was in nineteen forty five.

0:29:14.920 --> 0:29:19.600
<v Speaker 2>So we have some suggestive evidence. So, for example, there's

0:29:19.640 --> 0:29:22.960
<v Speaker 2>a paper in the Journal of Dental Research from twenty eighteen.

0:29:23.120 --> 0:29:27.800
<v Speaker 2>It takes the ENHNES which is a large nationally representative

0:29:28.440 --> 0:29:32.000
<v Speaker 2>study that's used for many things, and it compares kids

0:29:32.000 --> 0:29:35.920
<v Speaker 2>who live in counties with higher fluoridation versus lower and

0:29:35.960 --> 0:29:40.360
<v Speaker 2>the kids in the high fluoridation counties have fewer cavities

0:29:40.360 --> 0:29:43.800
<v Speaker 2>about thirty percent fewer cavities, and the others. The issue

0:29:43.880 --> 0:29:46.600
<v Speaker 2>is that these counties are really very different. They tend

0:29:46.640 --> 0:29:49.240
<v Speaker 2>to be different in sort of how rural versus urban,

0:29:49.280 --> 0:29:50.920
<v Speaker 2>they are, in their income, and all kinds of other

0:29:51.000 --> 0:29:54.040
<v Speaker 2>things that are also potentially driving cavities.

0:29:54.320 --> 0:29:57.280
<v Speaker 1>And hey, flag that thought because it's going to come

0:29:57.320 --> 0:30:00.480
<v Speaker 1>back when we talk about IQ differences like that.

0:30:01.120 --> 0:30:04.520
<v Speaker 2>This entire literature on both sides is rife with residual

0:30:04.560 --> 0:30:05.720
<v Speaker 2>confounding our favor.

0:30:06.920 --> 0:30:09.920
<v Speaker 1>One of the things that the sort of anti fluoride

0:30:10.000 --> 0:30:14.040
<v Speaker 1>groups talk about a lot is the Cochrane Review on

0:30:14.560 --> 0:30:16.720
<v Speaker 1>Water fluoridation. So Cochrane for those of you who don't know.

0:30:16.840 --> 0:30:20.920
<v Speaker 1>Is really the gold standard of the meta analysis world.

0:30:21.560 --> 0:30:25.920
<v Speaker 1>They're a very rigorous group that puts together meta analysis,

0:30:25.960 --> 0:30:30.320
<v Speaker 1>so combining multiple studies into one overall analysis to make

0:30:30.560 --> 0:30:34.640
<v Speaker 1>big important statements about all sorts of healthcare stuff. And

0:30:35.400 --> 0:30:39.880
<v Speaker 1>there is a Cochran review on fluoridation that gets cited

0:30:39.920 --> 0:30:43.360
<v Speaker 1>a lot where they say that there is no evidence

0:30:43.520 --> 0:30:46.840
<v Speaker 1>that the fluoridation of water supply after nineteen seventy five

0:30:46.960 --> 0:30:50.760
<v Speaker 1>had a meaningful effect on cavities. So nineteen seventy five

0:30:50.840 --> 0:30:54.280
<v Speaker 1>is the sort of arbitrary ish market in time when like, okay,

0:30:54.280 --> 0:30:56.520
<v Speaker 1>now there's florid toothpaste everywhere, like everyone has access to

0:30:56.520 --> 0:30:59.040
<v Speaker 1>florid toothpaste if they want it, so people trot that

0:30:59.040 --> 0:31:01.680
<v Speaker 1>out in like okay, there goes after nineteen seventy five.

0:31:01.760 --> 0:31:05.720
<v Speaker 5>There's no effects, so we're done. However, it's really no data.

0:31:06.560 --> 0:31:08.960
<v Speaker 5>It's almost no data after almost no data. The cock

0:31:09.000 --> 0:31:13.280
<v Speaker 5>Re review focuses on the initiation of fluoridation in a

0:31:13.320 --> 0:31:16.720
<v Speaker 5>water supply, and the truth is that very few places

0:31:17.280 --> 0:31:21.000
<v Speaker 5>both initiated fluoridation after nineteen seventy five. Most had already

0:31:21.040 --> 0:31:23.920
<v Speaker 5>done it and also studied it and published it in

0:31:24.360 --> 0:31:27.040
<v Speaker 5>a paper form that Cochrane could use, and so there

0:31:27.080 --> 0:31:31.160
<v Speaker 5>were only two studies that actually met their criteria for

0:31:31.240 --> 0:31:35.200
<v Speaker 5>a post nineteen seventy five fluoride initiation. The confidence intervals

0:31:35.240 --> 0:31:38.320
<v Speaker 5>around the effects sizes are incredibly wide. So this is

0:31:38.320 --> 0:31:40.600
<v Speaker 5>one of those like we just like the evidence just

0:31:40.760 --> 0:31:43.200
<v Speaker 5>isn't there one way or another, as opposed to it

0:31:43.240 --> 0:31:45.479
<v Speaker 5>doesn't really work and you don't get that nuance when

0:31:45.520 --> 0:31:47.160
<v Speaker 5>people talk about it on Instagram.

0:31:47.520 --> 0:31:50.680
<v Speaker 2>Yeah, I mean, just to be clear, the you know,

0:31:50.880 --> 0:31:53.960
<v Speaker 2>we have randomized trials of tooth based and tooth varnishes

0:31:54.000 --> 0:31:56.680
<v Speaker 2>and things on your teeth for fluoride, so that is

0:31:56.800 --> 0:31:59.720
<v Speaker 2>very very clear that that reduces cavities. This is really

0:31:59.800 --> 0:32:04.200
<v Speaker 2>a a sort of more epidemiological question and a big

0:32:04.240 --> 0:32:07.440
<v Speaker 2>piece of the problem with these with these studies is

0:32:07.480 --> 0:32:11.840
<v Speaker 2>that when everybody has floride in the water, then there

0:32:11.880 --> 0:32:14.040
<v Speaker 2>is no introduction of them and then you can't you

0:32:14.080 --> 0:32:18.240
<v Speaker 2>can't evaluate. But what you can do a little bit

0:32:18.240 --> 0:32:21.040
<v Speaker 2>and where I think the evidence is potentially more helpful

0:32:21.200 --> 0:32:23.520
<v Speaker 2>for the value of floridation of your water is the

0:32:23.520 --> 0:32:25.000
<v Speaker 2>places that stopped doing.

0:32:24.800 --> 0:32:27.800
<v Speaker 1>This, like Florida and Utah, are about to be Yeah.

0:32:27.640 --> 0:32:30.160
<v Speaker 2>Like Florida and Utah are about to and so I

0:32:30.200 --> 0:32:34.360
<v Speaker 2>think that you can imagine, you know, on the beginning side,

0:32:34.440 --> 0:32:37.320
<v Speaker 2>we have this very good evidence from what happened when

0:32:37.320 --> 0:32:40.320
<v Speaker 2>you first introduced floride to the water from zero. Now

0:32:40.360 --> 0:32:42.640
<v Speaker 2>everybody has it. So the only way you're really going

0:32:42.680 --> 0:32:45.960
<v Speaker 2>to figure out if it works from this point is

0:32:46.000 --> 0:32:48.960
<v Speaker 2>if you turn it off. Yeah, and there are some

0:32:49.000 --> 0:32:53.760
<v Speaker 2>places that have done that. So Calgary stopped floridating their

0:32:53.760 --> 0:32:58.720
<v Speaker 2>water in twenty eleven and they saw compared to Edmonton.

0:32:58.760 --> 0:33:03.400
<v Speaker 2>These are places in Canada apparently very nice places. I

0:33:03.480 --> 0:33:08.920
<v Speaker 2>love you Canada. They saw their cavities increase, not enormously

0:33:09.240 --> 0:33:13.680
<v Speaker 2>but somewhat. And we see sort of similar things in

0:33:13.800 --> 0:33:18.480
<v Speaker 2>some places in Alaska and in Israel. So Israel banned

0:33:18.480 --> 0:33:21.479
<v Speaker 2>community of fluoridation in twenty fourteen, and they actually saw

0:33:21.520 --> 0:33:25.320
<v Speaker 2>about a doubling of child dental visits afterwards based on

0:33:25.360 --> 0:33:29.520
<v Speaker 2>a time trend analysis. And so again time trends. You know,

0:33:30.400 --> 0:33:32.800
<v Speaker 2>people can always quibble, but I feel this is much

0:33:32.800 --> 0:33:36.000
<v Speaker 2>stronger evidence than say, comparing kids within fluorided versus not

0:33:36.040 --> 0:33:37.360
<v Speaker 2>fluorided areas.

0:33:37.960 --> 0:33:42.840
<v Speaker 1>And it also answers the public policy question better, which is,

0:33:43.040 --> 0:33:45.600
<v Speaker 1>you know, if people are talking about if your municipality

0:33:45.640 --> 0:33:48.880
<v Speaker 1>is debating whether or not to stop fluoridation. Well, we

0:33:48.960 --> 0:33:52.200
<v Speaker 1>have evidence of what happens when you stop floridation, and broadly,

0:33:52.320 --> 0:33:55.520
<v Speaker 1>the rate of cavities goes up, even in the modern era.

0:33:56.080 --> 0:33:58.720
<v Speaker 1>There's one other thing before we move on from this.

0:33:59.320 --> 0:34:02.120
<v Speaker 1>Does toothpaste to do the job well enough that I

0:34:02.160 --> 0:34:04.520
<v Speaker 1>want to talk about that I think maybe doesn't get

0:34:04.840 --> 0:34:08.400
<v Speaker 1>brought up enough, which is that there are substantial disparities

0:34:08.440 --> 0:34:13.400
<v Speaker 1>in dental care in the United States in particular. You know,

0:34:13.880 --> 0:34:17.719
<v Speaker 1>insurance coverage for dental procedures is poor even at the

0:34:17.719 --> 0:34:20.960
<v Speaker 1>best of times, and for many people they essentially have

0:34:21.040 --> 0:34:23.760
<v Speaker 1>no dental coverage. I think we take it for granted

0:34:24.000 --> 0:34:28.279
<v Speaker 1>sometimes that everyone has access to floride toothpaste, and has

0:34:28.600 --> 0:34:32.239
<v Speaker 1>a home environment that is encouraging of and has the

0:34:32.640 --> 0:34:35.960
<v Speaker 1>you know, ability to get people to brush teeth frequently,

0:34:36.080 --> 0:34:39.200
<v Speaker 1>and you know, parents are around to make sure their

0:34:39.280 --> 0:34:41.799
<v Speaker 1>kids can brush their teeth before they go to bed,

0:34:41.800 --> 0:34:43.719
<v Speaker 1>as opposed to being off at work and leaving kids

0:34:43.760 --> 0:34:45.759
<v Speaker 1>with a sitter and all these kinds of things. And so,

0:34:46.800 --> 0:34:52.759
<v Speaker 1>I you know, I think that if floridation stopped in

0:34:52.800 --> 0:34:57.120
<v Speaker 1>my area, my kids would be fine because they have

0:34:57.160 --> 0:34:59.160
<v Speaker 1>their Florida toothpaste, and they go to the dentist every

0:34:59.160 --> 0:35:00.920
<v Speaker 1>six months and they get clean and they can get

0:35:00.960 --> 0:35:03.920
<v Speaker 1>their fluoride varnishes, and even if they have a cavity,

0:35:03.960 --> 0:35:06.160
<v Speaker 1>we'll pick it up quickly and it'll get filled quickly

0:35:06.200 --> 0:35:09.200
<v Speaker 1>and everything will be fine, and they'll probably be fine.

0:35:09.239 --> 0:35:11.600
<v Speaker 1>And that's just not the case for all kids. And

0:35:12.160 --> 0:35:13.960
<v Speaker 1>one of the I'm going back to my sort of

0:35:14.040 --> 0:35:18.080
<v Speaker 1>concern about this pushback against public health is that hyper

0:35:18.080 --> 0:35:21.040
<v Speaker 1>individualism when it comes to health care decisions tends to

0:35:21.160 --> 0:35:24.640
<v Speaker 1>leave people behind that don't have the same privileges that

0:35:24.680 --> 0:35:25.319
<v Speaker 1>other people do.

0:35:25.920 --> 0:35:28.799
<v Speaker 2>Totally. I mean, I think I was. My brain was

0:35:28.840 --> 0:35:32.080
<v Speaker 2>in the same place on the thinking about vaccines that

0:35:32.160 --> 0:35:35.680
<v Speaker 2>you know, when we limit the access to basic public

0:35:35.680 --> 0:35:40.879
<v Speaker 2>health interventions, the people who lose are disproportionately people who

0:35:40.920 --> 0:35:45.280
<v Speaker 2>are have fewer other resources to make up for those losses.

0:35:45.320 --> 0:35:47.880
<v Speaker 2>And this is a very very clear place where there

0:35:47.920 --> 0:35:51.160
<v Speaker 2>is a huge, huge relationship between your socioeconomics that is,

0:35:51.160 --> 0:35:54.680
<v Speaker 2>your parental education, your parential income, and aspects of your

0:35:54.760 --> 0:36:00.440
<v Speaker 2>dental health where fluoride can fill in when some other

0:36:00.480 --> 0:36:00.960
<v Speaker 2>things are not.

0:36:01.480 --> 0:36:05.160
<v Speaker 1>There absolutely safety safety net fluoride basically.

0:36:04.920 --> 0:36:05.760
<v Speaker 2>Safety net florid.

0:36:06.000 --> 0:36:08.160
<v Speaker 1>You know, I just said, oh, hey, I can deal

0:36:08.200 --> 0:36:10.640
<v Speaker 1>with a cavity if I get to be fair, my

0:36:10.760 --> 0:36:12.880
<v Speaker 1>kids are not psyched about having a cavity at the

0:36:12.920 --> 0:36:16.240
<v Speaker 1>dentist and getting you know, novacaine and getting a tooth thrilled.

0:36:16.280 --> 0:36:19.280
<v Speaker 1>But I have certainly heard people say, look, cavities are fine,

0:36:19.320 --> 0:36:22.160
<v Speaker 1>we can deal with that. There's no, it's not that

0:36:22.280 --> 0:36:26.880
<v Speaker 1>bad essentially, and Emily, we have some data. You know,

0:36:26.920 --> 0:36:30.000
<v Speaker 1>it's probably obviously we're not randomizing kids to cavity versus

0:36:30.000 --> 0:36:34.200
<v Speaker 1>no cavity. But there are some adverse downstream effects of

0:36:34.440 --> 0:36:35.520
<v Speaker 1>dental health.

0:36:36.120 --> 0:36:40.200
<v Speaker 2>There are some correlations between talk to me about correlations. Yeah,

0:36:40.200 --> 0:36:43.680
<v Speaker 2>there are some correlations between dental problems and poor academic

0:36:43.760 --> 0:36:48.680
<v Speaker 2>performance and school absenteeism. These are these are correlations, They

0:36:48.719 --> 0:36:52.400
<v Speaker 2>are causal. I think the strongest arguments in favor of

0:36:53.080 --> 0:36:55.839
<v Speaker 2>you know, better fluoride better dental care are that it

0:36:55.840 --> 0:37:00.239
<v Speaker 2>improves people's teeth and experience of you know, being in

0:37:00.239 --> 0:37:03.160
<v Speaker 2>the world with their teeth. And there's actually some long

0:37:03.239 --> 0:37:07.600
<v Speaker 2>term illness things that relate to bacteria in your teeth,

0:37:07.719 --> 0:37:11.000
<v Speaker 2>so you know, definitely there's definitely a strong correlation with

0:37:11.080 --> 0:37:13.919
<v Speaker 2>academic performance. I read that as a reflection of who

0:37:13.920 --> 0:37:16.520
<v Speaker 2>has access to dental care rather than a reflection of

0:37:16.840 --> 0:37:19.960
<v Speaker 2>you know, your cavities directly impacting your task scores.

0:37:20.360 --> 0:37:25.360
<v Speaker 1>Fair enough, that's really the benefit of fluoride.

0:37:25.480 --> 0:37:27.960
<v Speaker 2>Well, it's good for your teeth, really good for your teeth.

0:37:29.280 --> 0:37:30.880
<v Speaker 1>I don't think that's what people want to talk about.

0:37:31.239 --> 0:37:35.920
<v Speaker 2>Nope, good, No, people want to talk about the brain.

0:37:36.880 --> 0:37:39.719
<v Speaker 2>We want to talk about the concern. And this is

0:37:39.800 --> 0:37:44.480
<v Speaker 2>the core issue here is the concern the fluoride exposure,

0:37:45.320 --> 0:37:52.040
<v Speaker 2>especially during pregnancy and in early childhood, is associated with

0:37:52.080 --> 0:37:56.879
<v Speaker 2>lower IQ. That is the core thing that people are

0:37:56.880 --> 0:37:59.680
<v Speaker 2>talking about. That's what people hear, and that is where

0:37:59.719 --> 0:38:03.160
<v Speaker 2>we want want to spend some time and give a

0:38:03.200 --> 0:38:04.400
<v Speaker 2>fair hearing to.

0:38:05.480 --> 0:38:14.719
<v Speaker 6>After the break, all right, we're back talking about fluoridation

0:38:15.000 --> 0:38:15.920
<v Speaker 6>and IQ.

0:38:16.200 --> 0:38:18.920
<v Speaker 1>And there are a lot of studies out there. There

0:38:18.960 --> 0:38:21.520
<v Speaker 1>are a lot of problems with studies on both sides

0:38:21.520 --> 0:38:24.680
<v Speaker 1>of this issue, but I think to give all the

0:38:24.760 --> 0:38:27.279
<v Speaker 1>data fair hearing, it's worth talking about the studies that

0:38:27.320 --> 0:38:30.200
<v Speaker 1>get sort of trotted out the most often so that

0:38:30.239 --> 0:38:32.200
<v Speaker 1>we can dig into them a little bit. And I

0:38:32.280 --> 0:38:36.520
<v Speaker 1>want to start with the quote unquote Harvard study you'll

0:38:36.560 --> 0:38:39.160
<v Speaker 1>hear this referred to as the Harvard Study. This is

0:38:39.160 --> 0:38:42.560
<v Speaker 1>a study that appeared in Environmental Health Perspectives in twenty twelve.

0:38:43.160 --> 0:38:45.799
<v Speaker 1>And just a little bit of an aside, a little

0:38:45.800 --> 0:38:50.239
<v Speaker 1>bit inside baseball here, just because an author works at

0:38:50.280 --> 0:38:52.840
<v Speaker 1>Harvard doesn't make it a Harvard study. Like when I

0:38:52.840 --> 0:38:56.080
<v Speaker 1>publish a study, it's not the Yale study. It's like

0:38:56.800 --> 0:38:58.680
<v Speaker 1>it's my own work. Okay, So this is not like

0:38:58.680 --> 0:38:59.600
<v Speaker 1>an official Well what.

0:38:59.680 --> 0:39:01.800
<v Speaker 2>Would what would make it the Harvard study?

0:39:01.960 --> 0:39:05.440
<v Speaker 1>I mean, I feel like if Harvard commissioned like a

0:39:05.480 --> 0:39:08.200
<v Speaker 1>study and they you know, but no, this is just

0:39:08.239 --> 0:39:09.120
<v Speaker 1>a lab at Harvard.

0:39:09.200 --> 0:39:09.359
<v Speaker 2>Day.

0:39:10.120 --> 0:39:13.319
<v Speaker 1>It's just a study. Yeah, okay, And as a as

0:39:13.360 --> 0:39:15.560
<v Speaker 1>a Yale guy, I just take issue with it and

0:39:15.640 --> 0:39:18.560
<v Speaker 1>a former Harvard guy, all right. The Harvard study is

0:39:18.560 --> 0:39:24.280
<v Speaker 1>a meta analysis of twenty seven studies looking at fluoride

0:39:24.320 --> 0:39:30.400
<v Speaker 1>exposure and IQ and children and the big the big

0:39:30.880 --> 0:39:35.120
<v Speaker 1>take home that people will say about this study is

0:39:35.160 --> 0:39:38.719
<v Speaker 1>that kids with a high exposure to fluoride had a

0:39:39.160 --> 0:39:44.280
<v Speaker 1>roughly seven point lower IQ than kids with a lower

0:39:44.360 --> 0:39:48.040
<v Speaker 1>exposure to fluoride. So we've got similar to what we

0:39:48.040 --> 0:39:50.880
<v Speaker 1>talked about before, you know, looking at places in the

0:39:50.920 --> 0:39:55.680
<v Speaker 1>world and differences in IQ A correlation, not causation. But hey,

0:39:55.719 --> 0:39:59.680
<v Speaker 1>it's the Harvard study. Fluoride reduces IQ. Emily, tell me

0:39:59.719 --> 0:40:02.480
<v Speaker 1>a bit more about the issues of the Harvard study.

0:40:02.800 --> 0:40:06.279
<v Speaker 2>So I think the important thing to understand about this

0:40:06.360 --> 0:40:10.319
<v Speaker 2>study is where most of these the studies they make

0:40:10.400 --> 0:40:14.000
<v Speaker 2>up the meta analysis come from, and what the water

0:40:14.200 --> 0:40:18.480
<v Speaker 2>levels looked like. So you know, we're talking we talk

0:40:18.520 --> 0:40:21.000
<v Speaker 2>about fluoridation in the US, We're talking about point seven

0:40:21.080 --> 0:40:24.160
<v Speaker 2>parts parts per million, and that's kind of where people

0:40:24.200 --> 0:40:28.040
<v Speaker 2>are aiming this meta analysis, mostly combining studies that are

0:40:28.080 --> 0:40:30.040
<v Speaker 2>run in parts of rural China that actually have very

0:40:30.080 --> 0:40:33.560
<v Speaker 2>high levels of groundwater fluoride. So this is not places

0:40:33.560 --> 0:40:36.280
<v Speaker 2>where they're adding fluoride to the water. It is places

0:40:36.280 --> 0:40:39.440
<v Speaker 2>where the underlying rock is full of fluoride. Actually, the

0:40:39.520 --> 0:40:42.759
<v Speaker 2>underlying rock is also often in these cases also full

0:40:42.800 --> 0:40:46.440
<v Speaker 2>of arsenic and lead. These are places with some iodine deficiency.

0:40:46.440 --> 0:40:49.880
<v Speaker 2>There's other kind of mineral differences.

0:40:50.200 --> 0:40:52.080
<v Speaker 1>But which often go together, by the way, like which

0:40:52.120 --> 0:40:54.719
<v Speaker 1>often go together. Yeah, groundwater florida and groundwater arsenic and

0:40:54.760 --> 0:40:59.160
<v Speaker 1>groundwater lead are correlated, particularly because of industrial runoff.

0:40:59.600 --> 0:41:03.800
<v Speaker 2>But the fluoride levels in this water are very high,

0:41:03.840 --> 0:41:07.399
<v Speaker 2>and so when they're estimating these impacts, they're effectively saying,

0:41:07.440 --> 0:41:09.640
<v Speaker 2>you know, how many IQ points. What's the effect on

0:41:09.680 --> 0:41:13.640
<v Speaker 2>IQ of increasing fluoride from an already high level to

0:41:13.719 --> 0:41:18.520
<v Speaker 2>an even higher level. And that is not really necessarily

0:41:18.560 --> 0:41:21.600
<v Speaker 2>the relevant question for what would happen if we have

0:41:21.640 --> 0:41:25.440
<v Speaker 2>small amounts of fluoride? And like with many things, and

0:41:25.600 --> 0:41:28.200
<v Speaker 2>this is the core underlying point, Like with many things,

0:41:28.239 --> 0:41:31.400
<v Speaker 2>the dose makes the poison, and very high levels of

0:41:31.400 --> 0:41:36.719
<v Speaker 2>fluoride could be dangerous or could be problematic for development,

0:41:37.239 --> 0:41:40.319
<v Speaker 2>while lower levels might not be. And this study is

0:41:40.400 --> 0:41:45.360
<v Speaker 2>really largely focused on these higher levels, even putting aside

0:41:45.440 --> 0:41:47.640
<v Speaker 2>the arsenic lead correlations.

0:41:48.120 --> 0:41:53.040
<v Speaker 1>Very well said these ecological studies the broad term here.

0:41:53.040 --> 0:41:55.440
<v Speaker 1>It's an ecological study where you're looking at an area,

0:41:55.840 --> 0:41:58.440
<v Speaker 1>really a geographic area. You have an estimate of florid

0:41:58.480 --> 0:42:00.000
<v Speaker 1>exposure in the area, you have an estimate of eye

0:42:00.080 --> 0:42:02.960
<v Speaker 1>Q in the area, and that's you're correlating those two things.

0:42:03.760 --> 0:42:06.560
<v Speaker 1>It's lower quality evidence, but we do have some I

0:42:06.560 --> 0:42:10.040
<v Speaker 1>think slightly higher quality evidence. There are studies that try

0:42:10.080 --> 0:42:14.600
<v Speaker 1>to measure fluoride exposure more directly, often with urinary fluoride,

0:42:14.640 --> 0:42:17.680
<v Speaker 1>and so I want to talk to you about this

0:42:18.440 --> 0:42:21.960
<v Speaker 1>study that appeared in Jama Pediatrics in twenty nineteen. This

0:42:22.080 --> 0:42:24.680
<v Speaker 1>is one of the more recent studies that used urinary fluoride.

0:42:25.560 --> 0:42:28.440
<v Speaker 1>It was called the Mirex study. Six hundred and one

0:42:28.640 --> 0:42:35.359
<v Speaker 1>mother child pairs across six Canadian cities, and what they

0:42:35.440 --> 0:42:40.080
<v Speaker 1>found was that an additional one milligram per leader of

0:42:40.400 --> 0:42:44.200
<v Speaker 1>fluoride was associated with a four point five lower IQ

0:42:44.360 --> 0:42:49.520
<v Speaker 1>points in boys, although no association in girls. It's a

0:42:49.560 --> 0:42:52.560
<v Speaker 1>little hard to understand why there'd be an effect in

0:42:52.600 --> 0:42:56.799
<v Speaker 1>one group not another. Emily, how do you interpret the

0:42:56.840 --> 0:42:57.600
<v Speaker 1>Mirax study.

0:42:58.520 --> 0:43:04.319
<v Speaker 2>I find the patterns in this study pretty problematic for

0:43:04.440 --> 0:43:06.759
<v Speaker 2>reasons that this is a kind of study where I

0:43:06.880 --> 0:43:09.520
<v Speaker 2>read it and I can see like fifty different problems

0:43:09.640 --> 0:43:11.560
<v Speaker 2>and it's not just one problem. You sometimes you look

0:43:11.560 --> 0:43:13.280
<v Speaker 2>at a study you're like, oh, here's the one issue.

0:43:13.640 --> 0:43:16.839
<v Speaker 2>This study has many issues. So the exposures here are

0:43:16.880 --> 0:43:20.040
<v Speaker 2>mostly low. There are a few very high exposure areas

0:43:20.080 --> 0:43:23.640
<v Speaker 2>that kind of seem to drive all the results. The

0:43:23.800 --> 0:43:28.719
<v Speaker 2>estimates are very very sensitive to adjustments for other family differences,

0:43:29.040 --> 0:43:32.680
<v Speaker 2>which suggests that there's other stuff going on. There's really

0:43:32.680 --> 0:43:35.080
<v Speaker 2>no reason to think that any kinds of effects here

0:43:35.080 --> 0:43:37.040
<v Speaker 2>would appear in boys and not for girls. So that's

0:43:37.080 --> 0:43:39.600
<v Speaker 2>just like feels a bit like what we call pea hacking,

0:43:39.719 --> 0:43:42.960
<v Speaker 2>just trying a bunch of different subjects, cherry picking your

0:43:43.160 --> 0:43:46.120
<v Speaker 2>your results. And it's a very small paper, you know,

0:43:46.120 --> 0:43:50.040
<v Speaker 2>it's a few hundred subjects. I don't find this to

0:43:50.080 --> 0:43:52.879
<v Speaker 2>be a very compelling paper for a lot of reasons, but.

0:43:52.880 --> 0:43:55.480
<v Speaker 1>It does get it gets brought out a lot of traction.

0:43:56.520 --> 0:43:59.960
<v Speaker 1>So a couple of things. First, urinary fluorie.

0:44:00.120 --> 0:44:04.399
<v Speaker 2>Because I'm a kidney doctor, it's about urine, guys, buckle up,

0:44:04.640 --> 0:44:06.400
<v Speaker 2>Parry's got feelings about the kidneys.

0:44:06.760 --> 0:44:08.480
<v Speaker 1>Just fast forward ten minutes if you want to skip

0:44:08.520 --> 0:44:11.560
<v Speaker 1>this part. No, it's not gonna say no. Just urinary

0:44:11.560 --> 0:44:14.600
<v Speaker 1>fluoride is actually not, in my opinion, the best measure

0:44:14.640 --> 0:44:17.600
<v Speaker 1>of fluoride exposure. When you measure anything in the urine,

0:44:17.640 --> 0:44:21.040
<v Speaker 1>you have to account for urinary concentration. So the concentration

0:44:21.080 --> 0:44:25.480
<v Speaker 1>of urine can vary from roughly one hundred millisms per

0:44:25.560 --> 0:44:27.719
<v Speaker 1>leader to a thousand milisms per leader. So that's a

0:44:27.760 --> 0:44:30.239
<v Speaker 1>factor of ten just based on you know, like how

0:44:30.239 --> 0:44:33.759
<v Speaker 1>concentrated your urine is. Many of these studies will adjust

0:44:33.920 --> 0:44:37.400
<v Speaker 1>for some other proxy of urine concentration, like specific gravity.

0:44:37.920 --> 0:44:40.520
<v Speaker 1>I'll just tell you as an nephrologist, specific gravity is

0:44:40.600 --> 0:44:44.200
<v Speaker 1>not a great concentration marker in the urine. Some use osmolarity,

0:44:44.200 --> 0:44:46.759
<v Speaker 1>which is a little bit better, but at least they

0:44:46.760 --> 0:44:50.800
<v Speaker 1>think about this. Fine. What no one ever thinks about

0:44:51.120 --> 0:44:56.520
<v Speaker 1>is urinary pH. So urine fluoride excretion is pH dependent

0:44:56.719 --> 0:45:00.920
<v Speaker 1>how acidic your urine is, okay, And the way it

0:45:00.960 --> 0:45:08.360
<v Speaker 1>works is that in a acidic urine, ninety five percent

0:45:08.560 --> 0:45:12.320
<v Speaker 1>of the filtered fluoride is reabsorbed before it gets into

0:45:12.360 --> 0:45:14.600
<v Speaker 1>the p that comes out of your body. Okay, So

0:45:15.040 --> 0:45:17.200
<v Speaker 1>if you're in a citic, you're absorbing a ton of fluoride.

0:45:17.239 --> 0:45:21.839
<v Speaker 1>In alkaline urine, only forty five percent is reabsorbed, which

0:45:21.880 --> 0:45:26.319
<v Speaker 1>is a dramatic difference. And so that means that the

0:45:26.360 --> 0:45:30.360
<v Speaker 1>pH of your urine can really drive any finding in

0:45:30.520 --> 0:45:33.520
<v Speaker 1>urinary fluoride that you want. And I've literally never seen

0:45:33.560 --> 0:45:36.279
<v Speaker 1>a paper that adjusts for urinary pH. I don't know

0:45:36.320 --> 0:45:39.120
<v Speaker 1>if the researchers are aware of it, but okay, guys, fi,

0:45:39.160 --> 0:45:41.640
<v Speaker 1>you've got to adjust for urinary pH. And a lot

0:45:41.680 --> 0:45:46.680
<v Speaker 1>of things affect urinary pH, including diet right, like when

0:45:46.680 --> 0:45:48.719
<v Speaker 1>you last date, and what kind of food and if

0:45:48.760 --> 0:45:51.440
<v Speaker 1>you have more vegetables or meats or all kinds of

0:45:51.440 --> 0:45:54.799
<v Speaker 1>things that could be salient here. So okay, everyone can

0:45:54.800 --> 0:45:57.200
<v Speaker 1>come back. Now I'm done talking about p I think.

0:45:57.160 --> 0:46:01.279
<v Speaker 2>What's okay? So what's interesting about this? And I like

0:46:01.600 --> 0:46:04.520
<v Speaker 2>very much. I don't ever think about urine ur aph

0:46:04.560 --> 0:46:06.600
<v Speaker 2>It's totally right. I've never literally never even heard of

0:46:06.600 --> 0:46:08.920
<v Speaker 2>it until right now. But I think what what this

0:46:09.080 --> 0:46:11.360
<v Speaker 2>illustrates that it is useful in many of these studies

0:46:11.480 --> 0:46:16.080
<v Speaker 2>is they can seem by saying we measured the we

0:46:16.160 --> 0:46:20.279
<v Speaker 2>measured the fluoride and the urine, it seems better, right, Like,

0:46:20.400 --> 0:46:22.920
<v Speaker 2>it seems a lot better than saying, you know, we

0:46:23.480 --> 0:46:26.680
<v Speaker 2>looked at it estimate. It's like, oh, it's a bi

0:46:26.800 --> 0:46:29.160
<v Speaker 2>It's like when people do brain scans. It's like looked

0:46:29.160 --> 0:46:32.120
<v Speaker 2>at the brain like so fancy. It's like a fancy metric.

0:46:32.400 --> 0:46:36.239
<v Speaker 2>But actually all of those metrics in this particular case

0:46:36.280 --> 0:46:39.080
<v Speaker 2>have some of the same problems that any measure would have.

0:46:39.160 --> 0:46:42.279
<v Speaker 2>You know, it's correlated with diet, it's correlated with other characteristics.

0:46:42.280 --> 0:46:45.440
<v Speaker 2>So just because something seems like a more sciencey measure

0:46:45.600 --> 0:46:49.279
<v Speaker 2>doesn't actually mean it's a it's a better measure or

0:46:49.320 --> 0:46:52.719
<v Speaker 2>a more accurate measure, or less subject to bias. Thank

0:46:52.760 --> 0:46:57.400
<v Speaker 2>you for coming to Perry's to talk about duran. So

0:46:58.200 --> 0:47:01.239
<v Speaker 2>I think this literature you can sort of tell from

0:47:01.239 --> 0:47:05.440
<v Speaker 2>some of this discussion is actually a bit confusing to

0:47:05.560 --> 0:47:07.799
<v Speaker 2>people because we're saying, Okay, there's this one study, the

0:47:07.840 --> 0:47:10.239
<v Speaker 2>things are kind of big, and there's another study, but

0:47:10.280 --> 0:47:13.880
<v Speaker 2>we don't like urine, and also I have some vague complaints.

0:47:14.400 --> 0:47:18.600
<v Speaker 2>For me, there is one kind of very nice paper

0:47:18.719 --> 0:47:23.640
<v Speaker 2>that helps me organize this, which is a meta analysis

0:47:23.640 --> 0:47:27.960
<v Speaker 2>from twenty twenty three, which took many of these studies

0:47:27.960 --> 0:47:30.680
<v Speaker 2>of water fluoride and just did this kind of quite

0:47:30.800 --> 0:47:36.480
<v Speaker 2>simple thing, but separated the studies into two groups. One

0:47:36.960 --> 0:47:41.239
<v Speaker 2>was studies that were in high fluoride areas, so these

0:47:41.280 --> 0:47:44.239
<v Speaker 2>are areas where the kind of underlying level is high,

0:47:44.280 --> 0:47:47.799
<v Speaker 2>and then they estimate what happens when you increase from there.

0:47:48.360 --> 0:47:50.799
<v Speaker 1>And then Indian China's of the world where there's just

0:47:50.840 --> 0:47:51.719
<v Speaker 1>a lot of florid around.

0:47:51.840 --> 0:47:54.680
<v Speaker 2>Yeah, And then also sort of separately looked at the

0:47:54.680 --> 0:47:57.440
<v Speaker 2>set of studies that were comparing that were looking at

0:47:57.440 --> 0:48:00.600
<v Speaker 2>the impacts of moving fluoride from a low level, much

0:48:00.600 --> 0:48:05.759
<v Speaker 2>of many of these in Canada and Mexico. And what

0:48:05.840 --> 0:48:08.719
<v Speaker 2>happens in the data you see this is that the

0:48:09.440 --> 0:48:11.680
<v Speaker 2>high areas, it looks like when you add more fluoride,

0:48:11.719 --> 0:48:14.839
<v Speaker 2>it's back for IQ in particular for development, because you're

0:48:14.840 --> 0:48:17.600
<v Speaker 2>already at this high level, but at these low levels,

0:48:18.200 --> 0:48:23.120
<v Speaker 2>at lower levels, the variation does not seem to relate

0:48:23.280 --> 0:48:26.960
<v Speaker 2>to IQ, which is exactly what you would expect if

0:48:27.400 --> 0:48:30.560
<v Speaker 2>this is bad for you at very high doses.

0:48:30.320 --> 0:48:35.000
<v Speaker 1>But not at lower doses. Once again, the dose makes

0:48:35.120 --> 0:48:38.600
<v Speaker 1>the poison. How are we doing in the US, like,

0:48:39.160 --> 0:48:44.120
<v Speaker 1>what percent of our fluoride is high? Yeah?

0:48:44.320 --> 0:48:47.640
<v Speaker 2>Are It's very very low. So the CDC had a

0:48:47.680 --> 0:48:50.640
<v Speaker 2>report in the kind of twenty sixteen to twenty one

0:48:50.760 --> 0:48:53.160
<v Speaker 2>period and they looked at, you know, what share of

0:48:53.160 --> 0:48:56.160
<v Speaker 2>the time was the water level above two milligrams per

0:48:56.239 --> 0:48:58.719
<v Speaker 2>liter and that is that is pretty high and so

0:48:58.840 --> 0:49:01.400
<v Speaker 2>you would want to bring it, bring it down. But

0:49:01.440 --> 0:49:05.000
<v Speaker 2>they found that happen in point zero one percent of

0:49:05.040 --> 0:49:08.040
<v Speaker 2>the cases that they looked at. And just to be clear,

0:49:08.200 --> 0:49:10.680
<v Speaker 2>even in those cases, it's not that the water is

0:49:10.760 --> 0:49:13.680
<v Speaker 2>always at this too high a level. These waters get

0:49:13.680 --> 0:49:15.600
<v Speaker 2>fixed when they are too high that's part of why

0:49:15.640 --> 0:49:19.880
<v Speaker 2>you monitor a municipal water system. So it's really unlikely

0:49:20.120 --> 0:49:23.600
<v Speaker 2>that people in the US are being consistently exposed to

0:49:24.480 --> 0:49:27.880
<v Speaker 2>fluoride at levels that are consistently too high. Actually, if anything,

0:49:27.920 --> 0:49:30.680
<v Speaker 2>the CDC found sort of systematic errors in the other

0:49:30.920 --> 0:49:32.600
<v Speaker 2>directly too low based on targeting.

0:49:33.040 --> 0:49:37.759
<v Speaker 1>Yeah, a lot of the studies that show these effects

0:49:37.920 --> 0:49:41.960
<v Speaker 1>are cross sectional, so they're measuring, you know, urinary fluoride

0:49:42.000 --> 0:49:45.800
<v Speaker 1>and IQ at the same time or maybe just once over,

0:49:45.920 --> 0:49:48.279
<v Speaker 1>you know, at a certain age. I just wanted to

0:49:48.320 --> 0:49:50.560
<v Speaker 1>call attention to the Broadband study which appeared in the

0:49:50.560 --> 0:49:54.080
<v Speaker 1>American Journal of Public Health. Just a really elegant piece

0:49:54.120 --> 0:49:58.040
<v Speaker 1>of epidemiology which you often don't see, where they followed

0:49:58.640 --> 0:50:02.800
<v Speaker 1>everyone born in Dunid in New Zealand between April nineteen

0:50:02.800 --> 0:50:05.440
<v Speaker 1>seventy two and March nineteen seventy three. Every single person

0:50:05.480 --> 0:50:07.720
<v Speaker 1>who was born that year got enrolled in this study

0:50:07.800 --> 0:50:10.440
<v Speaker 1>in this town, which is so cool. And they followed

0:50:10.440 --> 0:50:13.960
<v Speaker 1>them for thirty eight years longitudinally, like big part of

0:50:14.000 --> 0:50:19.000
<v Speaker 1>their lives, and they were measuring prospectively floride exposure and

0:50:19.040 --> 0:50:23.080
<v Speaker 1>they had repeated IQ testing. And in that broadband study

0:50:23.160 --> 0:50:26.520
<v Speaker 1>there were no differences in IQ based on floride exposure,

0:50:26.600 --> 0:50:32.040
<v Speaker 1>so repeated high quality measurements over time. Again, you can

0:50:32.040 --> 0:50:34.160
<v Speaker 1>find studies on both sides of this issue, but I

0:50:34.200 --> 0:50:35.799
<v Speaker 1>just wanted to make sure there's some balance that, Like,

0:50:35.840 --> 0:50:38.800
<v Speaker 1>it's not like every study, even though they're bad, finds

0:50:38.880 --> 0:50:39.400
<v Speaker 1>a finding.

0:50:39.800 --> 0:50:42.000
<v Speaker 2>Yeah, I mean, I think just you know, my big

0:50:42.360 --> 0:50:45.640
<v Speaker 2>like general takeaway from this is it is true that

0:50:45.800 --> 0:50:50.000
<v Speaker 2>high fluoride in water, like endemically high fluoride, seems to

0:50:50.000 --> 0:50:53.560
<v Speaker 2>have some negative impacts on IQ. The levels that we

0:50:53.640 --> 0:50:55.920
<v Speaker 2>have in American tap water do not seem to have

0:50:56.120 --> 0:50:59.680
<v Speaker 2>those effects. And quoting the first one doesn't make this

0:50:59.680 --> 0:51:01.280
<v Speaker 2>second one true.

0:51:01.800 --> 0:51:03.960
<v Speaker 1>I certainly agree, but I will say I'm not even

0:51:04.000 --> 0:51:07.800
<v Speaker 1>sure that the high florid levels affect IQ. I honestly,

0:51:07.840 --> 0:51:09.680
<v Speaker 1>I don't have a great mechanism for that, Like, I

0:51:09.680 --> 0:51:12.640
<v Speaker 1>don't know why that would be. And secondly, there's just

0:51:13.239 --> 0:51:17.239
<v Speaker 1>so much confounding when you know you're living next to

0:51:17.360 --> 0:51:20.920
<v Speaker 1>an industrial runoff site so your groundwater fluoride levels is spiking.

0:51:21.560 --> 0:51:23.320
<v Speaker 2>Yeah, is a very fair point.

0:51:23.680 --> 0:51:26.880
<v Speaker 1>I also let's talk about kids IQ, because this is

0:51:26.920 --> 0:51:30.720
<v Speaker 1>how this always gets framed. And Emily, this is firmly

0:51:30.840 --> 0:51:33.920
<v Speaker 1>in your wheelhouse is the only if we really care

0:51:34.640 --> 0:51:38.279
<v Speaker 1>about IQ and our children, is fluoride the only lever

0:51:38.440 --> 0:51:41.239
<v Speaker 1>we have to pull? Or like, have there been other studies,

0:51:41.880 --> 0:51:45.640
<v Speaker 1>ideally randomized studies that would suggest that we can move

0:51:45.680 --> 0:51:47.319
<v Speaker 1>the needle on IQ in kids.

0:51:47.360 --> 0:51:51.279
<v Speaker 2>Broadly speaking, there are many studies that suggest that we

0:51:51.360 --> 0:51:54.759
<v Speaker 2>can move the IQ, the move the needle on children's

0:51:54.800 --> 0:51:58.960
<v Speaker 2>IQ and children's development. They range from you know, in

0:51:59.040 --> 0:52:02.759
<v Speaker 2>low resource environment and some very basic stuff like micro

0:52:02.840 --> 0:52:09.120
<v Speaker 2>nutrient supplementation, like improved iodine, Like let's talk about other

0:52:09.160 --> 0:52:13.600
<v Speaker 2>metals that we enjoy. You know, iodine supplementation can be

0:52:14.120 --> 0:52:17.160
<v Speaker 2>can be helpful if people are truly are truly deficient.

0:52:17.239 --> 0:52:19.959
<v Speaker 2>And then all kinds of evidence on you know, early

0:52:20.040 --> 0:52:25.880
<v Speaker 2>childhood education, better preschool access, headstart, you support for parents, like,

0:52:25.880 --> 0:52:29.520
<v Speaker 2>there's so much in that we could be doing overall

0:52:29.600 --> 0:52:34.480
<v Speaker 2>to improve IQ that would have potentially much larger impacts

0:52:35.080 --> 0:52:40.919
<v Speaker 2>than not giving people fluoride, which is like a crazy yeah.

0:52:41.239 --> 0:52:45.279
<v Speaker 1>The only difference is that stopping fluoridation costs nothing at

0:52:45.320 --> 0:52:47.680
<v Speaker 1>least it doesn't cost the government anything it you know,

0:52:47.760 --> 0:52:49.839
<v Speaker 1>might cost us in terms of public health, whereas all

0:52:49.840 --> 0:52:51.600
<v Speaker 1>of these other interventions you know, you have to have

0:52:51.640 --> 0:52:54.759
<v Speaker 1>an item in the budget, right, But this is high

0:52:54.840 --> 0:52:59.799
<v Speaker 1>quality data. We've randomized controlled data that suggests, you know,

0:53:00.640 --> 0:53:04.040
<v Speaker 1>nutritional supplementation for kids at high risk will improve IQ

0:53:04.400 --> 0:53:05.280
<v Speaker 1>in the long term.

0:53:05.440 --> 0:53:08.480
<v Speaker 2>We have look, we have randomized data that reading to

0:53:08.680 --> 0:53:11.640
<v Speaker 2>kids improves their IQ. You know that's like that is

0:53:11.680 --> 0:53:15.160
<v Speaker 2>a well documented fact. And you know who helps with that.

0:53:15.520 --> 0:53:17.719
<v Speaker 2>Dolly Parton. Do you know that Dolly Parton has a

0:53:17.719 --> 0:53:21.520
<v Speaker 2>program where every kid get in Tennessee gets She has

0:53:21.680 --> 0:53:24.520
<v Speaker 2>a whole thing where you can get like free books. Yeah,

0:53:24.600 --> 0:53:26.719
<v Speaker 2>by Dolly Parton. Like, Dolly Parton is doing more for

0:53:26.840 --> 0:53:31.359
<v Speaker 2>kids IQ, like buy a billion margins than any even

0:53:31.440 --> 0:53:35.000
<v Speaker 2>potential Flora thing. It's like, why aren't we more focused

0:53:35.000 --> 0:53:35.680
<v Speaker 2>on Dolly Parton.

0:53:35.800 --> 0:53:37.720
<v Speaker 1>I think you can get a free book from Dolly Parton,

0:53:37.760 --> 0:53:38.800
<v Speaker 1>not to anyone.

0:53:38.440 --> 0:53:39.800
<v Speaker 2>You can get a free book from her and you

0:53:39.840 --> 0:53:41.319
<v Speaker 2>can read it to your kids and that would be

0:53:41.360 --> 0:53:42.719
<v Speaker 2>amazing because she's the best.

0:53:44.880 --> 0:53:46.080
<v Speaker 1>Thank you so great.

0:53:45.840 --> 0:53:48.359
<v Speaker 2>Everyone, It's like the greatest thing. Okay, this is now

0:53:48.360 --> 0:53:52.440
<v Speaker 2>a Dolly Parton fan, there you go.

0:53:52.960 --> 0:53:57.000
<v Speaker 1>Let's just touch on the little bit wackier stuff that

0:53:57.080 --> 0:54:00.479
<v Speaker 1>I've seen from the influencers, which is that Flora will

0:54:00.520 --> 0:54:03.520
<v Speaker 1>calcify your pineal gland, which is actually the third eye,

0:54:03.600 --> 0:54:06.480
<v Speaker 1>which gives you your psychic powers. And really the reason

0:54:06.520 --> 0:54:10.719
<v Speaker 1>for fluoridation is that it's to tamp down our psychic abilities.

0:54:10.960 --> 0:54:14.880
<v Speaker 1>Now I will admit that I have no psychic abilities,

0:54:15.320 --> 0:54:17.319
<v Speaker 1>and so maybe that's why I am.

0:54:17.600 --> 0:54:20.520
<v Speaker 2>I'm you know some, I have some, but that's you know,

0:54:20.560 --> 0:54:25.320
<v Speaker 2>it's because my tooth hygiene is kind of limited. How

0:54:25.400 --> 0:54:28.759
<v Speaker 2>would one show that psychic abilities, which are made up

0:54:29.120 --> 0:54:30.759
<v Speaker 2>are affected by fluoride?

0:54:30.760 --> 0:54:30.960
<v Speaker 4>Oh?

0:54:31.000 --> 0:54:33.959
<v Speaker 1>Emily, boy, did I look. I was like, there's got

0:54:33.960 --> 0:54:36.600
<v Speaker 1>to be some wack gotta be such journal. There's gotta

0:54:36.640 --> 0:54:39.080
<v Speaker 1>be some wackado journal that And I literally I couldn't

0:54:39.080 --> 0:54:42.760
<v Speaker 1>find anything on psychic abilities. I did. Yes, your pineal gland,

0:54:43.200 --> 0:54:46.040
<v Speaker 1>I should say. The pineal gland secretes melatonin, which is

0:54:46.080 --> 0:54:49.200
<v Speaker 1>the like sleepy chemicals. That's that's good, and it does

0:54:49.280 --> 0:54:52.400
<v Speaker 1>calcify as you get older. It is a part of

0:54:52.440 --> 0:54:54.960
<v Speaker 1>the brain that is particularly prone to this. About sixty

0:54:55.000 --> 0:54:57.600
<v Speaker 1>percent of people, based on autopsy studies, will have a

0:54:57.640 --> 0:55:00.760
<v Speaker 1>calcified pineal gland, and it can contribute to sleep difficulties

0:55:01.000 --> 0:55:04.360
<v Speaker 1>in people in their later life. There is no evidence

0:55:04.400 --> 0:55:08.720
<v Speaker 1>that fluoride accelerates this process, it's just other aging stuff

0:55:09.040 --> 0:55:12.719
<v Speaker 1>that does it. However, the crystal that forms in your

0:55:12.760 --> 0:55:15.799
<v Speaker 1>pineal gland is hydroxy.

0:55:15.280 --> 0:55:17.840
<v Speaker 2>Appetite, same things in the tooth enamel.

0:55:17.960 --> 0:55:21.319
<v Speaker 1>That is the and fluoride binds to hydroxy appetite. So

0:55:21.440 --> 0:55:23.520
<v Speaker 1>if you test it, you'll find fluoride there. But it's

0:55:23.560 --> 0:55:26.960
<v Speaker 1>the same reason that you find fluorid wherever hydroxy appetite is.

0:55:27.719 --> 0:55:32.160
<v Speaker 1>It's not affecting your psychic ability. Obviously, everyone knows that

0:55:32.200 --> 0:55:35.160
<v Speaker 1>psychic ability lives in the super chismatic nucleus.

0:55:36.960 --> 0:55:38.759
<v Speaker 2>What is that a reference? I can't even what I mean?

0:55:40.320 --> 0:55:42.920
<v Speaker 1>That is the central control of that.

0:55:43.360 --> 0:55:44.759
<v Speaker 2>We're like back to star trek.

0:55:45.320 --> 0:55:47.680
<v Speaker 1>Oh No, what does psychic ability start to?

0:55:47.840 --> 0:55:51.280
<v Speaker 2>Okay, moving on, Okay.

0:55:50.880 --> 0:55:53.800
<v Speaker 1>I want to put this all together in a way

0:55:53.880 --> 0:55:56.160
<v Speaker 1>like I want to give respect to the people that

0:55:56.239 --> 0:55:59.680
<v Speaker 1>study the impact of florid on kids, and I don't

0:55:59.680 --> 0:56:02.560
<v Speaker 1>want to it. I think there's a tendency in science

0:56:02.600 --> 0:56:05.759
<v Speaker 1>circles to be like that study was bad or had

0:56:05.760 --> 0:56:08.000
<v Speaker 1>a flaw, or wasn't perfect or wasn't how I would

0:56:08.040 --> 0:56:10.640
<v Speaker 1>do it, and therefore I can disregard it totally. And

0:56:10.719 --> 0:56:13.920
<v Speaker 1>I don't think that's fair. The way we need to

0:56:13.960 --> 0:56:20.080
<v Speaker 1>interpret science is based both on the effect that is positive, right,

0:56:20.120 --> 0:56:24.160
<v Speaker 1>the estimate of impact of the thing, and the quality

0:56:24.200 --> 0:56:27.120
<v Speaker 1>of the research. And I think the problem that people

0:56:27.200 --> 0:56:32.640
<v Speaker 1>have here is that when the effect posited is bad

0:56:33.160 --> 0:56:36.720
<v Speaker 1>or concerning or makes you uncomfortable, like affecting the brain

0:56:36.760 --> 0:56:40.000
<v Speaker 1>of a developing child, right, there's a real ick factor

0:56:40.000 --> 0:56:46.440
<v Speaker 1>there that we tend to ignore that we should interpret

0:56:46.480 --> 0:56:49.040
<v Speaker 1>that in the context of the quality of research, Like

0:56:49.280 --> 0:56:52.240
<v Speaker 1>we're willing to accept a worse study with a bigger

0:56:52.280 --> 0:56:56.280
<v Speaker 1>effect or a worse seeming effect than we would a

0:56:56.320 --> 0:57:01.640
<v Speaker 1>better designed study with no effect or a not gross

0:57:01.719 --> 0:57:05.000
<v Speaker 1>or icky effect. And I think that's a problem. And

0:57:05.000 --> 0:57:06.839
<v Speaker 1>I bet there's an economics term for it, but I'm

0:57:06.840 --> 0:57:07.719
<v Speaker 1>not sure what it is.

0:57:08.520 --> 0:57:10.640
<v Speaker 2>Not exactly, I mean, I think it is a problem,

0:57:10.880 --> 0:57:14.080
<v Speaker 2>and it encompasses a bunch of issues that people have

0:57:14.239 --> 0:57:17.200
<v Speaker 2>with with cognition. I think one of them is just

0:57:17.360 --> 0:57:20.000
<v Speaker 2>the idea of of sort of salience. So once you

0:57:20.080 --> 0:57:22.600
<v Speaker 2>tell people you know, there's a like this might affect

0:57:22.600 --> 0:57:24.560
<v Speaker 2>your kid's brain, like it's kind of living in there

0:57:24.600 --> 0:57:26.720
<v Speaker 2>and I can't sort of take it out. It just

0:57:26.760 --> 0:57:31.040
<v Speaker 2>makes that fear very salient and real to me and

0:57:31.480 --> 0:57:34.880
<v Speaker 2>then hard to subject to a basic like you know,

0:57:35.240 --> 0:57:40.200
<v Speaker 2>rational risk benefit calculation. I also think this is a

0:57:40.240 --> 0:57:44.600
<v Speaker 2>place where it's difficult to see either the risks or

0:57:45.160 --> 0:57:48.400
<v Speaker 2>benefits for real, Like you you know, let's say something

0:57:48.440 --> 0:57:50.640
<v Speaker 2>did lower your kid's IQ by one point, you would

0:57:50.680 --> 0:57:52.760
<v Speaker 2>never know, Like that's not meaningful.

0:57:52.880 --> 0:57:55.360
<v Speaker 1>Yeah, this is something you can even if it's real,

0:57:55.400 --> 0:57:58.240
<v Speaker 1>you can only detect across thousands of kids, not one

0:57:58.280 --> 0:57:58.720
<v Speaker 1>kid yet.

0:57:59.120 --> 0:58:01.080
<v Speaker 2>And also so like your kid's going to get some

0:58:01.120 --> 0:58:03.000
<v Speaker 2>cavities and you're not going to know whether it's good

0:58:03.040 --> 0:58:05.800
<v Speaker 2>fluoride or not. So this we're all kind of arguing

0:58:05.880 --> 0:58:11.360
<v Speaker 2>in a sort of diffuse, ambiguous space, and that gives

0:58:11.360 --> 0:58:14.160
<v Speaker 2>a lot of value to just like I don't know

0:58:14.160 --> 0:58:16.040
<v Speaker 2>stuff that lives in like what is what is living

0:58:16.080 --> 0:58:19.040
<v Speaker 2>in your head more aggressively at the moment, And fear

0:58:19.120 --> 0:58:20.840
<v Speaker 2>is more salient than reassurance.

0:58:21.000 --> 0:58:24.960
<v Speaker 1>That's yes, yeah, this is driven by fear. It doesn't

0:58:25.000 --> 0:58:28.200
<v Speaker 1>mean that there's nothing to worry about. But we do

0:58:28.280 --> 0:58:31.280
<v Speaker 1>have to acknowledge that the studies are generally of poor quality,

0:58:31.440 --> 0:58:34.160
<v Speaker 1>and you shouldn't live your life based on fear of

0:58:34.360 --> 0:58:37.440
<v Speaker 1>poor quality studies, and you should be happy that our

0:58:37.520 --> 0:58:41.720
<v Speaker 1>kids are not dying of cholera and dysentery, which is

0:58:41.760 --> 0:58:45.200
<v Speaker 1>a real possibility for kids all around the world. Just

0:58:45.240 --> 0:58:47.280
<v Speaker 1>to bring it back to the other stuff we add

0:58:47.280 --> 0:58:47.880
<v Speaker 1>to water.

0:58:48.760 --> 0:58:51.960
<v Speaker 2>All right, Perry, fluoride in the water. Smash your pass.

0:58:52.520 --> 0:58:56.480
<v Speaker 1>I am a smash. I think the fluoride benefits people

0:58:56.560 --> 0:58:59.360
<v Speaker 1>with the least access, which is generally what I'm for

0:58:59.400 --> 0:59:03.240
<v Speaker 1>from a public health standpoint. And I think you should

0:59:03.240 --> 0:59:06.240
<v Speaker 1>also read to your children, Emily, smash your pass.

0:59:06.560 --> 0:59:11.160
<v Speaker 2>I'm a smash on Floyd, and I hope that we

0:59:11.280 --> 0:59:14.520
<v Speaker 2>keep it in our municipal water supply. That's what I

0:59:14.520 --> 0:59:14.920
<v Speaker 2>would like.

0:59:15.600 --> 0:59:18.400
<v Speaker 1>All right, Florida, We'll see what happens. That's it for

0:59:18.440 --> 0:59:21.800
<v Speaker 1>Floride your mail bag Question of the Week after the Break.

0:59:26.840 --> 0:59:31.080
<v Speaker 7>Hi, Emily and Perry. This is Natasha from Massachusetts. My

0:59:31.200 --> 0:59:34.320
<v Speaker 7>question came from your episode last week on gluten sensitivity,

0:59:34.360 --> 0:59:37.280
<v Speaker 7>and it's about MSG. A lot of older people in

0:59:37.320 --> 0:59:40.720
<v Speaker 7>my life, especially ones I go to Chinese restaurants with,

0:59:41.240 --> 0:59:44.600
<v Speaker 7>are convinced that MSG is responsible for headaches, brain fog,

0:59:44.760 --> 0:59:47.440
<v Speaker 7>everything that's wrong in the world. I've even heard it

0:59:47.480 --> 0:59:51.040
<v Speaker 7>called Chinese restaurants syndrome. Is this actually a real thing.

0:59:51.800 --> 0:59:55.360
<v Speaker 7>MSG tastes so good it would be such a bummer

0:59:55.400 --> 0:59:56.920
<v Speaker 7>to cut it out if you don't have to.

0:59:57.600 --> 0:59:59.800
<v Speaker 2>Thanks so much, Emily.

1:00:00.560 --> 1:00:04.600
<v Speaker 1>Do you have MSG powder in your house?

1:00:05.680 --> 1:00:05.840
<v Speaker 4>No?

1:00:06.520 --> 1:00:08.640
<v Speaker 2>I do, do you? I just sit next to your

1:00:08.800 --> 1:00:11.000
<v Speaker 2>to your like mac and cheese, cheese that you use

1:00:11.080 --> 1:00:11.560
<v Speaker 2>on everything.

1:00:13.160 --> 1:00:15.640
<v Speaker 1>I have a lot of powders. It's in my spice rack.

1:00:16.320 --> 1:00:19.840
<v Speaker 1>I'm a big fan of MSG. So before we answer

1:00:19.840 --> 1:00:21.680
<v Speaker 1>the question of whether you can be allergic to MSG,

1:00:21.960 --> 1:00:27.080
<v Speaker 1>I have to say the science here is fascinating. MSG.

1:00:27.240 --> 1:00:32.760
<v Speaker 1>Monosodium glue tomate is a chemical that binds to certain

1:00:32.800 --> 1:00:36.280
<v Speaker 1>receptors on your tongue. They're called T one R one

1:00:36.280 --> 1:00:39.040
<v Speaker 1>and T one R three, which are the specific umammy

1:00:39.160 --> 1:00:44.600
<v Speaker 1>taste receptors. So this the umami flavor, which is that's

1:00:44.640 --> 1:00:51.280
<v Speaker 1>sort of like meaty, robust type of flavor comes from

1:00:51.280 --> 1:00:55.600
<v Speaker 1>food that has glutamate in it. It's an unctuous flavor absolutely,

1:00:57.440 --> 1:01:00.760
<v Speaker 1>and whenever you taste something umammy, like whether it's like

1:01:00.880 --> 1:01:03.080
<v Speaker 1>mushrooms or things like that, it is the glue tomate.

1:01:03.680 --> 1:01:06.160
<v Speaker 1>It's not from monoodium glutamate, but it is glutamate binding

1:01:06.200 --> 1:01:08.440
<v Speaker 1>to those receptors that gives you that flavor. So we

1:01:08.480 --> 1:01:10.640
<v Speaker 1>all kind of like that flavor truffles like that kind

1:01:10.680 --> 1:01:13.560
<v Speaker 1>of stuff. That's all glue, tomate, monosodium glutamate. It's just

1:01:13.560 --> 1:01:16.640
<v Speaker 1>a sodium attached to the glutamate, and sodium is salt,

1:01:16.800 --> 1:01:18.080
<v Speaker 1>you know, and so.

1:01:17.800 --> 1:01:19.400
<v Speaker 2>It's just like a salty.

1:01:19.760 --> 1:01:23.960
<v Speaker 1>It's just it's just mummy, as much as like sucrose

1:01:24.200 --> 1:01:27.520
<v Speaker 1>is the sweet, and citric acid is kind of a prototypical,

1:01:27.840 --> 1:01:33.280
<v Speaker 1>you know, sour. Monosorium glutamate is umammy, and it's it's

1:01:33.320 --> 1:01:36.480
<v Speaker 1>quite delicious. But Emily, you tell me, can you be

1:01:36.480 --> 1:01:39.280
<v Speaker 1>allergic or maybe I should say sensitive.

1:01:40.520 --> 1:01:44.080
<v Speaker 2>There's really no evidence that people can be sensitive to this,

1:01:44.920 --> 1:01:47.640
<v Speaker 2>and and you know, in fact, it would be surprising

1:01:47.880 --> 1:01:51.200
<v Speaker 2>given that you also have sodium and you also have glutamate,

1:01:51.200 --> 1:01:53.240
<v Speaker 2>as you have outlined, and so the idea that like

1:01:53.320 --> 1:01:56.720
<v Speaker 2>together they would cause something that would be different from

1:01:56.960 --> 1:02:00.160
<v Speaker 2>separate is not doesne have a lot of mechanistic I

1:02:00.160 --> 1:02:03.520
<v Speaker 2>think people just like eat too much from the restaurant

1:02:03.560 --> 1:02:04.520
<v Speaker 2>and then they feel tired.

1:02:05.480 --> 1:02:09.320
<v Speaker 1>Yes, one hundred percent. This is a classic example of

1:02:09.760 --> 1:02:13.160
<v Speaker 1>you know, MSG being effect being used in cooking, and

1:02:13.480 --> 1:02:16.000
<v Speaker 1>there's a lot of other stuff that gets used in cooking.

1:02:17.040 --> 1:02:21.840
<v Speaker 1>You know, Chinese restaurants do. Asian cooking in general does

1:02:21.920 --> 1:02:25.600
<v Speaker 1>add MSG sometimes as a spice, much like I do

1:02:25.800 --> 1:02:29.240
<v Speaker 1>sometimes just like adding salt or adding sugar or adding

1:02:29.240 --> 1:02:32.400
<v Speaker 1>citric acid or whatever. But it is in all the

1:02:32.440 --> 1:02:35.080
<v Speaker 1>other foods you eat too that have that bit of

1:02:35.600 --> 1:02:38.720
<v Speaker 1>flavor profile. And yeah, you just really can't be allergic

1:02:38.760 --> 1:02:40.400
<v Speaker 1>to it. But there's a lot of salt and other

1:02:40.440 --> 1:02:42.720
<v Speaker 1>stuff in that type of cooking which can make you

1:02:42.720 --> 1:02:46.320
<v Speaker 1>a little field dehydrated and gross, and it's also really delicious,

1:02:46.360 --> 1:02:48.040
<v Speaker 1>so you get full and sleepy and tired.

1:02:48.440 --> 1:02:50.720
<v Speaker 2>Definitely, Yeah, it would be a mistake. Don't blame the MSG,

1:02:50.840 --> 1:02:56.000
<v Speaker 2>but just drink some extra water. All right. That's it

1:02:56.040 --> 1:02:58.160
<v Speaker 2>for us today. Stick with us next week when we'll

1:02:58.200 --> 1:03:00.480
<v Speaker 2>ask what's the deal with ticks?

1:03:01.600 --> 1:03:05.040
<v Speaker 1>The bugs? Not the Thurett's syndrome thing with bugs?

1:03:05.080 --> 1:03:11.360
<v Speaker 2>Ticks the bug. Wellness actually is produced in association with iHeartMedia.

1:03:11.760 --> 1:03:15.440
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1:03:39.920 --> 1:03:42.560
<v Speaker 1>a question for our mailbag or suggest a topic for

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<v Speaker 1>a future show.

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<v Speaker 2>We'll let the influencers have the last word.

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<v Speaker 1>I'm going to expose some things on about fluoride.

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<v Speaker 5>Why have we been told we have fluoride in the

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<v Speaker 5>drinking water.

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<v Speaker 1>Prevent tooth to ku?

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<v Speaker 3>We're told that too, right, so is I