WEBVTT - Special Episode: John Green & Everything Is Tuberculosis

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<v Speaker 1>Hi, I'm Aaron Welsh and this is this Podcast Will

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<v Speaker 1>Kill You. Welcome to our very first tp w k

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<v Speaker 1>Y book Club episode of the season. In these episodes,

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<v Speaker 1>I get to chat with authors of popular science and

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<v Speaker 1>medicine books about their latest work, and I get it

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<v Speaker 1>behind the scenes look at what goes into putting these

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<v Speaker 1>books together. I am so excited to be bringing you

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<v Speaker 1>more of these episodes over this next year, and we

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<v Speaker 1>Two final things to mention before moving on to the

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<v Speaker 1>miss an episode. All right, let's get to the real

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<v Speaker 1>reason we're here. John Green's Everything Is Tuberculosis. I know

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<v Speaker 1>that many of you out there, like me, have been

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<v Speaker 1>eagerly awaiting this book's publication, and let me tell you

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<v Speaker 1>that it is well worth the wait, and its arrival

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<v Speaker 1>could not have come at a better time, as tuberculosis

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<v Speaker 1>cases surge across the globe amidst massive funding cuts to

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<v Speaker 1>global health programs such as USAID. In Everything Is Tuberculosis, Green,

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<v Speaker 1>award winning, internationally best selling author, famous YouTuber, and excellent

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<v Speaker 1>science communicator, takes a panoramic view of this fascinating and

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<v Speaker 1>deadly disease, linking its biology and history with the perception

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<v Speaker 1>and prevalence of tuberculosis today. For many of US, tuberculosis

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<v Speaker 1>may conjure up Charles Dickens or long abandoned sanatoriums in

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<v Speaker 1>Upstate New York. But as Green describes, tuberculosis is far

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<v Speaker 1>from a disease relegated to the past. Despite the fact

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<v Speaker 1>that curative treatments for this disease have existed for decades,

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<v Speaker 1>hence those sanatoriums being abandoned, tuberculosis remains a significant contributor

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<v Speaker 1>to morbidity and mortality around the world. This is a

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<v Speaker 1>disease caused by a microorganism, Mycobacterium tuberculosis, but it's also

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<v Speaker 1>so much more than that. Over the centuries, people have

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<v Speaker 1>ascribed various meanings to tuberculosis, each of which carries the

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<v Speaker 1>significant burden of othering. It has been used to romanticize

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<v Speaker 1>and stigmatize. It has changed the course of history in

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<v Speaker 1>untold ways, and it stands today as a deadly consequence

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<v Speaker 1>of how the global health care decisions that are driven

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<v Speaker 1>by profit lead to unnecessary death and suffering for millions

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<v Speaker 1>of people around the world. Through his heartfelt and incisive writing,

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<v Speaker 1>Green demonstrates the human cost of tuberculosis and how intervention

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<v Speaker 1>is not only possible but necessary. It was an absolutely

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<v Speaker 1>surreal delight to get to chat with John, and I

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<v Speaker 1>am very excited to share our conversation with you all,

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<v Speaker 1>So let's get right to it after this short break. John,

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<v Speaker 1>thank you so much for joining me today. I really

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<v Speaker 1>can't tell you what a thrill it is to get

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<v Speaker 1>to chat with you.

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<v Speaker 2>Oh well, thank you, Erin. It's great to be here.

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<v Speaker 2>I'm a fan of the pod.

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<v Speaker 1>That is so thrilling. That absolutely made my day. So

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<v Speaker 1>usually I start off these book club episodes by asking

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<v Speaker 1>someone how did you get the idea for this book

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<v Speaker 1>or how did this book come to be? But today,

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<v Speaker 1>with you, I'd love to begin by asking about Henry.

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<v Speaker 1>Can you tell me how meeting Henry started you on

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<v Speaker 1>this journey that led to this book.

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<v Speaker 2>Sure, in twenty nineteen, I had no idea that tuberculosis

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<v Speaker 2>is the world's deadliest infectious disease. I would have been

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<v Speaker 2>stunned to hear that. I was visiting Sierra Leone with

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<v Speaker 2>my wife, where we work with Partners in health on

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<v Speaker 2>maternal mortality infant mortality in the Cono region, and on

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<v Speaker 2>the last day of the trip, some of the doctors

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<v Speaker 2>we were traveling with asked if we could go to

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<v Speaker 2>a tuberculosis hospital, and I was like, tuberculosis hospital, that's

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<v Speaker 2>still a thing, right. I hadn't listened to enough of

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<v Speaker 2>the pod, so when we got to the hospital, I

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<v Speaker 2>was immediately grabbed, like physically grabbed by the shirt by

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<v Speaker 2>a boy whose name was Henry, which is also my

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<v Speaker 2>son's name. And this boy appeared to be about the

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<v Speaker 2>same age as my son, who was nine at the time,

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<v Speaker 2>and this boy started walking me around the hospital. Most

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<v Speaker 2>sier Leonians are multi lingual, but Henry spoke particularly good

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<v Speaker 2>English for a young child, and so I was able

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<v Speaker 2>to kind of talk with him and enjoy the conversation

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<v Speaker 2>with him. And he took me to the lab where

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<v Speaker 2>he showed me a microscope and told me to look

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<v Speaker 2>for TB bacteria in the microscope. He took me around

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<v Speaker 2>the wards, he took me to the kitchen where the

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<v Speaker 2>food was being made, and then eventually we made our

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<v Speaker 2>way back to the entrance of the hospital where the

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<v Speaker 2>doctors were meeting, and one of the nurses sort of

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<v Speaker 2>lovingly showed him away, and I was like, whose kid

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<v Speaker 2>is that? Is that like a doctor's kid, and they

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<v Speaker 2>were like, no, that's one of the patients we're really

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<v Speaker 2>worried about. And it turned out he wasn't nine years old,

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<v Speaker 2>he was seventeen. He'd just been so emaciated, stunted by

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<v Speaker 2>mountnourishment and then emaciated, further emaciated by tuberculosis. And it

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<v Speaker 2>was really through meeting Henry and knowing Henry that I

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<v Speaker 2>came to be interested in tuberculosis. I came home after

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<v Speaker 2>that trip and just started reading voraciously about the disease,

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<v Speaker 2>trying to understand how there'd been this massive hole in

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<v Speaker 2>my understanding of the world around me.

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<v Speaker 1>Yeah, it is. You know, there's this statistic that you

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<v Speaker 1>say early on in your book about one hundred and

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<v Speaker 1>fifty million people having died since we've had a cure

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<v Speaker 1>for tuberculosis, and that's just been like circulating and echoing

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<v Speaker 1>in my head over and over again, and I pull

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<v Speaker 1>people aside and I'm like, did you know this? And

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<v Speaker 1>I feel like it is so it's such a stark

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<v Speaker 1>statistic because it really cuts to this core question of

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<v Speaker 1>like how did we allow this to happen? And later

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<v Speaker 1>in our conversation, I do want to touch on more

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<v Speaker 1>of like the details of that, but like, broadly speaking,

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<v Speaker 1>can you kind of take me through what are some

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<v Speaker 1>of the major drivers in allowing that number to grow

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<v Speaker 1>every single year?

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<v Speaker 2>Yeah, I think the biggest driver is choice, human choice.

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<v Speaker 2>We have chosen to live in a world with tuberculosis.

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<v Speaker 2>We've chosen to live in a world where in countries

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<v Speaker 2>like Germany or the US or Australia, TB is very rare,

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<v Speaker 2>and in countries like sier Leone or even middle income

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<v Speaker 2>countries like India and the Philippines, TV is very common.

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<v Speaker 2>And some of that is because TV is difficult to cure.

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<v Speaker 2>You know, it takes four to six months of daily

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<v Speaker 2>antibiotics with the newest regimens it used to take even longer,

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<v Speaker 2>and so it's it's a hard disease to cure. But

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<v Speaker 2>my brother had Hodgkin lymphoma a couple of years ago,

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<v Speaker 2>which is also a hard disease to cure, but curable,

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<v Speaker 2>and there was no question as to whether or not

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<v Speaker 2>he would receive treatment, or whether or not we would

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<v Speaker 2>do a good job of getting him treatment. Doctor Peter Mugeny,

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<v Speaker 2>this great Ugandan physician, said in two thousand of HIV drugs,

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<v Speaker 2>which were still not getting to where they were most

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<v Speaker 2>needed at the time, he said, where the drugs, the

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<v Speaker 2>drugs are where the disease is not, and where is

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<v Speaker 2>the disease the disease is where the drugs are not.

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<v Speaker 2>And that's very much still the case with tuberculosis.

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<v Speaker 1>Yeah, absolutely, And you know, I want to kind of

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<v Speaker 1>circle back to the current present and then the potential

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<v Speaker 1>future in a bit, but let's take a step back

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<v Speaker 1>and look at the deep history of tuberculosis. I mean,

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<v Speaker 1>this is a disease that has been with humans for millennia,

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<v Speaker 1>and yet, as with many other infectious diseases, it is

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<v Speaker 1>rarely acknowledged outside of you know, specific disease history books,

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<v Speaker 1>you know on influenza or on cholera, as like this

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<v Speaker 1>major force that is shaping historical events. I've wondered this

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<v Speaker 1>so much, like why is that? Why do we not

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<v Speaker 1>consider the role of an infectious disease in shaping history?

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<v Speaker 2>Well, I think it's a great mystery. But in the book,

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<v Speaker 2>I argue that one of the reasons we do is

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<v Speaker 2>that we're so biased toward human agency. We love a

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<v Speaker 2>story where humans are in control, and we love a

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<v Speaker 2>story where humans make choices rather than have those choices

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<v Speaker 2>made for them by micro organisms or viruses. Like that's

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<v Speaker 2>an uncomfortable thing to live with. So I speculate in

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<v Speaker 2>the book that maybe the reason we continue to spread

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<v Speaker 2>the rumor that Alexander the Great died by poisoning when

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<v Speaker 2>he almost certainly died of malaria or typhoid, is that

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<v Speaker 2>we just don't want to reckon with a world where

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<v Speaker 2>where the most powerful person on earth can be killed

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<v Speaker 2>by a tiny bacteria or virus.

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<v Speaker 1>Let's take a quick break, and when we get back,

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<v Speaker 1>there's still so much to discuss. Welcome back everyone. I've

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<v Speaker 1>been chatting with John Green about his latest book, Everything

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<v Speaker 1>Is Tuberculosis. Let's get back into things. I mean, especially

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<v Speaker 1>when you're when examining wars and the history of wars,

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<v Speaker 1>like generals aren't acting in isolation, and neither are the

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<v Speaker 1>diseases that are spreading throughout the entire military or through

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<v Speaker 1>war torn regions. You can't look at these diseases or

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<v Speaker 1>these factors leading to disease individually, which is a point

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<v Speaker 1>that you bring up in your book, that we can't

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<v Speaker 1>look even at tuberculosis through these narrow lenses. That being said,

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<v Speaker 1>I'd love to ask you about a few specific influences

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<v Speaker 1>that tuberculosis has had throughout history, especially on the granting

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<v Speaker 1>of statehood and early twentieth century global politics.

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<v Speaker 2>Sure, I mean it's very unlikely New Mexico would have

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<v Speaker 2>become a state, or at least become a state when

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<v Speaker 2>it did, without tuberculos, because New Mexico had all the

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<v Speaker 2>institutions needed for statehood, and it wanted statehood, but Congress

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<v Speaker 2>repeatedly rejected it because it had such a large Spanish

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<v Speaker 2>speaking population, for just reasons of outright racism, and also

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<v Speaker 2>because it had a large population of indigenous people. And

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<v Speaker 2>so New Mexico realized that in order to become a state,

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<v Speaker 2>it needed to attract more white residents. And the way

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<v Speaker 2>that it did that was making itself sort of a

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<v Speaker 2>advertising itself as a great place for people with consumption

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<v Speaker 2>to come and recover. Had the dry air, it had

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<v Speaker 2>the sunshine, and at the time we believed that sunshine

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<v Speaker 2>and dry air would sort of heal the wet lungs

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<v Speaker 2>of consumption. And so by I think by nineteen hundred,

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<v Speaker 2>about ten percent of all people living in New Mexico

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<v Speaker 2>were tuberculosis patients, and there were enough of them that

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<v Speaker 2>Congress eventually acknowledged that New Mexico should become a state

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<v Speaker 2>in accordance with its desires, and that's how, or one

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<v Speaker 2>of the reasons why New Mexico became a state in

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<v Speaker 2>the first place. Then you have something like World War One.

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<v Speaker 2>You know, I think you're so right that every war

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<v Speaker 2>is shaped by disease. The Franco Prussian War was shaped

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<v Speaker 2>in part by the fact that one side had access

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<v Speaker 2>to antiseptics and the other side didn't, and so, you know,

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<v Speaker 2>injuries that were utterly unsurvivable five years earlier were suddenly survivable.

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<v Speaker 2>But with TB in particular, I'm fascinated by the role

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<v Speaker 2>that TV played in World War One because all three

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<v Speaker 2>of the assassins who sort of semi succeeded in killing

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<v Speaker 2>the Archduke Frans Ferdinand, knew that they were dying of consumption.

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<v Speaker 2>They were all quite sick, and they knew that they

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<v Speaker 2>were dying, and they wanted to die for a great cause,

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<v Speaker 2>as young people often do. And they thought this great

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<v Speaker 2>cause was the nationalism of their community being able to

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<v Speaker 2>be a nation independent of the Austro Hungarian Empire. And

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<v Speaker 2>that's why they assassinated the Archduke Franz Ferdinand. All three

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<v Speaker 2>of those boys, they were nineteen, and I think all

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<v Speaker 2>three of them were nineteen died within a couple of

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<v Speaker 2>years of tuberculosis after assassinating the Archduke.

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<v Speaker 1>That is wild to think about that this disease could

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<v Speaker 1>have such far reaching consequences, and I'd love to hear

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<v Speaker 1>more about one of these consequences slightly less extreme than

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<v Speaker 1>a World war maybe, And that is why we may

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<v Speaker 1>have tuberculosis to think or blame, depending on who you

0:14:31.960 --> 0:14:33.680
<v Speaker 1>ask for the cowboy hat.

0:14:34.000 --> 0:14:36.920
<v Speaker 2>Oh yeah, no, that's an interesting one. So this young

0:14:37.000 --> 0:14:39.760
<v Speaker 2>hat maker was living in New Jersey, his name was John,

0:14:40.560 --> 0:14:44.560
<v Speaker 2>and he got TB and was told that his only

0:14:44.640 --> 0:14:47.840
<v Speaker 2>chance of survival was to head west, which young people

0:14:47.880 --> 0:14:51.480
<v Speaker 2>were often told, especially young men who got consumption, and

0:14:51.560 --> 0:14:54.240
<v Speaker 2>so he headed west. He only made it as far

0:14:54.240 --> 0:14:57.160
<v Speaker 2>as Saint Joseph's, Missouri, which might be the most humid,

0:14:57.520 --> 0:15:02.520
<v Speaker 2>least dry airplace I've ever been and personally, but nonetheless

0:15:02.600 --> 0:15:05.520
<v Speaker 2>that's where he ended up. And while he was there

0:15:05.320 --> 0:15:08.000
<v Speaker 2>he recovered. So about twenty five percent of people, for

0:15:08.080 --> 0:15:12.760
<v Speaker 2>reasons we still don't really understand, recover spontaneously from tuberculosis.

0:15:13.800 --> 0:15:15.840
<v Speaker 2>One of the things that made it such a difficult

0:15:15.880 --> 0:15:20.760
<v Speaker 2>disease to deal with societally was its unpredictable and is

0:15:20.880 --> 0:15:25.400
<v Speaker 2>its unpredictable course? And so John recovered and as he

0:15:25.480 --> 0:15:28.000
<v Speaker 2>recovered this hat, this young hat maker noticed that the

0:15:28.040 --> 0:15:30.000
<v Speaker 2>hats in the West weren't very good. There were the

0:15:30.080 --> 0:15:34.480
<v Speaker 2>kind of coonskin caps that were bug infested and gross,

0:15:34.520 --> 0:15:38.120
<v Speaker 2>and then there were straw hats that folk from Mexico

0:15:38.160 --> 0:15:41.720
<v Speaker 2>and Texas had brought up to Missouri, but those didn't

0:15:41.720 --> 0:15:45.120
<v Speaker 2>hold up particularly well in the rain. And so eventually

0:15:45.240 --> 0:15:48.320
<v Speaker 2>John B. Stetson invented what we now know is the

0:15:48.320 --> 0:15:49.760
<v Speaker 2>stetson or the cowboy hat.

0:15:50.320 --> 0:15:53.240
<v Speaker 1>It's amazing that that final reveal of like and then

0:15:53.400 --> 0:15:56.560
<v Speaker 1>Stetson was his last name. Yeah, it's really good. Also,

0:15:56.600 --> 0:15:59.640
<v Speaker 1>it's just it's so funny that like, it was just

0:15:59.720 --> 0:16:02.160
<v Speaker 1>all of these different factors combining. I mean, it's what

0:16:02.200 --> 0:16:04.480
<v Speaker 1>I love about history and how we can make these

0:16:04.520 --> 0:16:09.840
<v Speaker 1>different connections. But yeah, so humans have long given different

0:16:09.960 --> 0:16:12.640
<v Speaker 1>meanings to disease in part to you know, make sense

0:16:12.680 --> 0:16:15.280
<v Speaker 1>of the world, to answer why me or why them?

0:16:15.560 --> 0:16:18.600
<v Speaker 1>And that meaning seems like it varies a lot depending

0:16:18.600 --> 0:16:21.920
<v Speaker 1>on how the disease is transmitted, who's affected, or what

0:16:21.960 --> 0:16:25.360
<v Speaker 1>the disease looks like like on the outside, something like

0:16:25.520 --> 0:16:29.480
<v Speaker 1>plague compared to tuberculosis, for instance, And for a long

0:16:29.480 --> 0:16:34.280
<v Speaker 1>period of time, tuberculosis, as you discussed, was romanticized. Why

0:16:34.440 --> 0:16:36.920
<v Speaker 1>was such a devastating disease seen this way?

0:16:37.600 --> 0:16:39.440
<v Speaker 2>Well, I think you make a really good point that

0:16:39.520 --> 0:16:41.920
<v Speaker 2>part of it is the outward appearance of the disease,

0:16:42.000 --> 0:16:46.000
<v Speaker 2>right like Mycobacterium, tuberculosis is very closely related to the

0:16:46.040 --> 0:16:49.760
<v Speaker 2>bacteria that causes leprosy, and leprosy, of course, is perceived

0:16:49.880 --> 0:16:53.000
<v Speaker 2>very differently because it's seen as a disfiguring disease rather

0:16:53.080 --> 0:16:56.640
<v Speaker 2>than as an ennobling one, although at times leprosy has

0:16:56.640 --> 0:16:59.560
<v Speaker 2>also been seen as ennobling because of its connection to Jesus,

0:16:59.600 --> 0:17:06.040
<v Speaker 2>at least in the Christian world. But with TV, everybody

0:17:06.600 --> 0:17:12.360
<v Speaker 2>started to get it. In the late eighteenth century in England,

0:17:13.119 --> 0:17:16.960
<v Speaker 2>about a third of all people who died died of tuberculosis.

0:17:17.480 --> 0:17:19.520
<v Speaker 2>About a third of all death was caused by TV.

0:17:19.720 --> 0:17:21.200
<v Speaker 1>It's a staggering statistic.

0:17:21.400 --> 0:17:25.080
<v Speaker 2>Staggering, I mean, it was completely overwhelming. One writer referred

0:17:25.080 --> 0:17:28.399
<v Speaker 2>to it as the frightful tuberculization of humanity and it

0:17:28.480 --> 0:17:32.000
<v Speaker 2>was terrifying. Yeah, And so how do you make sense

0:17:32.040 --> 0:17:35.080
<v Speaker 2>of a disease that, as Charles Dickens put it, wealth

0:17:35.160 --> 0:17:38.360
<v Speaker 2>never warded off. A disease that you can't easily stigmatize,

0:17:38.400 --> 0:17:42.200
<v Speaker 2>a disease that doesn't just affect poor people or marginalized people.

0:17:42.240 --> 0:17:44.240
<v Speaker 2>I mean, the richest guy of the nineteenth century died

0:17:44.240 --> 0:17:47.000
<v Speaker 2>of tuberculosis. How do you make sense of that disease?

0:17:47.040 --> 0:17:48.680
<v Speaker 2>And I think one of the ways we made sense

0:17:48.720 --> 0:17:51.280
<v Speaker 2>of it was through stigma, and another way we made

0:17:51.320 --> 0:17:53.639
<v Speaker 2>sense of it was through romanticization. And it's easy to

0:17:53.680 --> 0:17:58.280
<v Speaker 2>think of those things as opposites. One dehumanizes someone, one

0:17:58.480 --> 0:18:00.639
<v Speaker 2>argues that someone is sort of like more more than human,

0:18:00.760 --> 0:18:03.280
<v Speaker 2>more beautiful than is possible if you're a regular human.

0:18:03.680 --> 0:18:07.240
<v Speaker 2>But they're really alternate ways of othering the sick, you know,

0:18:07.480 --> 0:18:10.760
<v Speaker 2>just kind of creating a world where the sick exists

0:18:10.800 --> 0:18:13.840
<v Speaker 2>that isn't the so called normal world or the healthy

0:18:13.880 --> 0:18:18.159
<v Speaker 2>world or whatever. And the romanticization of tuberculosis was so

0:18:18.359 --> 0:18:21.320
<v Speaker 2>intense in Northern Europe and the United States that it's

0:18:21.359 --> 0:18:25.040
<v Speaker 2>really hard to overstate. It was really really weird. Looking

0:18:25.080 --> 0:18:28.880
<v Speaker 2>back on it, it feels weird to us. Men were said

0:18:28.920 --> 0:18:33.399
<v Speaker 2>to become geniuses because they had tuberculosis. I think I

0:18:33.440 --> 0:18:36.399
<v Speaker 2>write in the book about when Shelley found out that

0:18:36.480 --> 0:18:39.000
<v Speaker 2>Keats had tuberculosis. He was like, well, you know, this

0:18:39.200 --> 0:18:41.560
<v Speaker 2>is a disease that affects people who write good verses

0:18:41.560 --> 0:18:44.400
<v Speaker 2>as you have done, which I think is especially funny

0:18:44.640 --> 0:18:48.560
<v Speaker 2>or sad or whatever it is, because Shelley also had tuberculosis,

0:18:48.960 --> 0:18:51.040
<v Speaker 2>and so he was kind of like patting himself on

0:18:51.080 --> 0:18:55.040
<v Speaker 2>the back, even if he was complimenting Shohn Keiths. But

0:18:55.119 --> 0:18:57.280
<v Speaker 2>also like for women, it was seen as this disease

0:18:57.320 --> 0:18:59.359
<v Speaker 2>that made you really beautiful, you know, it made you

0:18:59.480 --> 0:19:02.560
<v Speaker 2>very pale, and whiteness of the skin was really kind

0:19:02.560 --> 0:19:05.080
<v Speaker 2>of worshiped at the time. It gave you rosy cheeks,

0:19:05.119 --> 0:19:08.160
<v Speaker 2>and so people would use rouge to try to affect

0:19:08.200 --> 0:19:14.240
<v Speaker 2>the same outcome as tuberculosis. It gave you big sunken eyes,

0:19:14.960 --> 0:19:17.480
<v Speaker 2>and so people would apply belladonna to their eyelids to

0:19:17.520 --> 0:19:23.840
<v Speaker 2>make their pupils look appropriately tubercular. And I think all

0:19:23.920 --> 0:19:27.679
<v Speaker 2>of this was an attempt to make sense of the crisis,

0:19:28.160 --> 0:19:31.359
<v Speaker 2>an attempt to just deal in some way with the

0:19:31.400 --> 0:19:35.280
<v Speaker 2>fact that an overwhelming number of people were dying young.

0:19:36.000 --> 0:19:40.520
<v Speaker 1>The words like tubercular and tuberculized, tubercular, what is it tuberculization.

0:19:41.800 --> 0:19:47.360
<v Speaker 1>It's what other infectious diseases have so many derivative words

0:19:47.840 --> 0:19:51.280
<v Speaker 1>developed from them. It's remarkable. And you know, I think

0:19:51.640 --> 0:19:54.920
<v Speaker 1>this again, these statistics that you bring up one third

0:19:55.520 --> 0:19:58.240
<v Speaker 1>of everyone you know dying of tuberculos or who died

0:19:58.280 --> 0:20:02.480
<v Speaker 1>died of tuberculosis. This is so it's so fascinating because

0:20:02.920 --> 0:20:07.040
<v Speaker 1>in contrast with other infectious diseases during that time, you know,

0:20:07.240 --> 0:20:11.160
<v Speaker 1>in the pre antibiotic, pre an acceptive, pre vaccine era,

0:20:11.920 --> 0:20:15.000
<v Speaker 1>they the spread was so different too, you know, plague

0:20:15.119 --> 0:20:17.960
<v Speaker 1>tour through a community caller, a tour through a community, typhus,

0:20:18.000 --> 0:20:20.920
<v Speaker 1>all these things, and to some degree or another, maybe

0:20:20.960 --> 0:20:23.919
<v Speaker 1>they weren't quite as what does Dick and say, they

0:20:23.920 --> 0:20:27.560
<v Speaker 1>weren't quite as wealth never warded off. But at the

0:20:27.600 --> 0:20:30.200
<v Speaker 1>same time, like, how do you think that that played

0:20:30.200 --> 0:20:34.439
<v Speaker 1>a role the way that tuberculosis spread so insidiously in

0:20:34.480 --> 0:20:34.840
<v Speaker 1>a way.

0:20:35.440 --> 0:20:37.119
<v Speaker 2>Yeah, and this is a really I think that's a

0:20:37.200 --> 0:20:41.560
<v Speaker 2>really important point. Tuberculosis was almost universally in Northern Europe

0:20:41.560 --> 0:20:44.600
<v Speaker 2>believed to be inherited, and so it was seen as

0:20:44.600 --> 0:20:48.120
<v Speaker 2>a hereditary disease that ran in families, and that as

0:20:48.160 --> 0:20:51.720
<v Speaker 2>such also came with certain other personality traits the way

0:20:51.800 --> 0:20:54.119
<v Speaker 2>that those are also passed down in families, and one

0:20:54.160 --> 0:20:58.119
<v Speaker 2>of those personality traits, this was called spez tysika, I

0:20:58.119 --> 0:21:03.879
<v Speaker 2>think the burular spirit. And one of these personality traits

0:21:03.880 --> 0:21:06.199
<v Speaker 2>was that you were very sensitive, if you're a very

0:21:06.280 --> 0:21:09.320
<v Speaker 2>deep thinker, you were attuned to the suffering in the world,

0:21:10.119 --> 0:21:12.919
<v Speaker 2>and you were also quite quite beautiful and wispy. This

0:21:13.000 --> 0:21:17.480
<v Speaker 2>idea that as the body shrank, the spirit grew was

0:21:17.600 --> 0:21:20.520
<v Speaker 2>very powerful at the time. But because it was seen

0:21:20.560 --> 0:21:23.480
<v Speaker 2>as hereditary, as opposed to a disease like cholera or

0:21:23.520 --> 0:21:26.399
<v Speaker 2>typhus or plague that would just tear through a community,

0:21:26.760 --> 0:21:29.240
<v Speaker 2>and even if it wasn't quite understood to be infectious,

0:21:29.240 --> 0:21:33.800
<v Speaker 2>it was certainly understood to be something weird and not inherited.

0:21:34.400 --> 0:21:37.760
<v Speaker 2>That changed the way that consumption was imagined in the

0:21:37.800 --> 0:21:40.240
<v Speaker 2>eighteenth and nineteenth centuries, which is why it was such

0:21:40.240 --> 0:21:43.600
<v Speaker 2>a big deal when Robert Coch discovered that tuberculosis was

0:21:43.640 --> 0:21:47.600
<v Speaker 2>in fact caused by a bacteria like cholera, like anthrax,

0:21:47.760 --> 0:21:50.480
<v Speaker 2>like the other diseases that were coming to be understood

0:21:50.480 --> 0:21:51.240
<v Speaker 2>as infectious.

0:21:51.560 --> 0:21:53.639
<v Speaker 1>I want to kind of get into that switch of

0:21:54.080 --> 0:21:57.640
<v Speaker 1>what that medicalization of tuberculosis meant. But before I want

0:21:57.680 --> 0:22:01.480
<v Speaker 1>to ask how we can see the effects of tuberculosis

0:22:01.520 --> 0:22:03.840
<v Speaker 1>in the art and literature of the day. I know

0:22:03.880 --> 0:22:06.560
<v Speaker 1>we've mentioned Dickens a couple of times, but it's everywhere

0:22:06.600 --> 0:22:08.840
<v Speaker 1>else and Shelley and yeah.

0:22:08.359 --> 0:22:11.800
<v Speaker 2>It's everywherewhere. It's everywhere, and not just in Western art.

0:22:11.800 --> 0:22:14.840
<v Speaker 2>It's also I write a lot about the Japanese and

0:22:14.880 --> 0:22:18.359
<v Speaker 2>Indian artists and poets who lived with tuberculosis. But in

0:22:18.640 --> 0:22:22.360
<v Speaker 2>Northern Europe in the nineteenth century, because there was this

0:22:22.680 --> 0:22:28.640
<v Speaker 2>romanticization of tuberculosis, there was also a romanticization that affected

0:22:28.760 --> 0:22:33.640
<v Speaker 2>art and poetry. You see paintings by Toulouse Latrek, for instance,

0:22:34.400 --> 0:22:37.400
<v Speaker 2>of a woman applying rice powder to her face and

0:22:37.440 --> 0:22:41.280
<v Speaker 2>she's very pale. The great actor Eliza Poe, who was

0:22:41.400 --> 0:22:45.640
<v Speaker 2>Edgar Allan Poe's mother, looked stereotypically tubercular and was sort

0:22:45.640 --> 0:22:49.439
<v Speaker 2>of worshiped for her beauty. And you see it a

0:22:49.440 --> 0:22:53.000
<v Speaker 2>lot in poetry. I mean, Keats writes about youth growing specter,

0:22:53.119 --> 0:22:56.560
<v Speaker 2>thin and dying, which is of course precisely what happened

0:22:56.560 --> 0:22:58.760
<v Speaker 2>to him when he was just twenty five years old.

0:22:59.000 --> 0:23:02.720
<v Speaker 2>And so I think from poetry to visual art to theater.

0:23:03.480 --> 0:23:08.239
<v Speaker 2>Tuberculosis played a huge role in shaping the both what

0:23:08.280 --> 0:23:13.120
<v Speaker 2>we sort of thought of as beautiful but also what

0:23:13.160 --> 0:23:16.560
<v Speaker 2>we thought of as very fragile. You know, at the time,

0:23:16.800 --> 0:23:21.440
<v Speaker 2>we really associated beauty with a kind of fragility, of fleetingness,

0:23:21.480 --> 0:23:23.679
<v Speaker 2>you know, that the idea that maybe you won't be

0:23:23.760 --> 0:23:25.720
<v Speaker 2>in the world for very long, but you'll be very

0:23:25.760 --> 0:23:30.879
<v Speaker 2>beautiful while you're here. Victor Hugo, I remember his friends

0:23:30.880 --> 0:23:32.760
<v Speaker 2>would joke with him that he would become a great

0:23:32.800 --> 0:23:36.760
<v Speaker 2>novelist if only he got tuberculosis. That's how much it

0:23:36.880 --> 0:23:39.840
<v Speaker 2>was believed that this disease made you a great artist.

0:23:40.320 --> 0:23:43.240
<v Speaker 1>The name consumption comes from the fact that, like it

0:23:43.800 --> 0:23:47.280
<v Speaker 1>is a consuming disease, so how it's just it's fascinating

0:23:47.320 --> 0:23:49.320
<v Speaker 1>to think about how that connection was made. How can

0:23:49.359 --> 0:23:53.920
<v Speaker 1>you produce novels or plays or pieces of art while

0:23:53.960 --> 0:23:55.840
<v Speaker 1>you are being consumed from the inside.

0:23:56.080 --> 0:23:59.280
<v Speaker 2>I think that's exactly right. I mean, look, this romanticization

0:23:59.320 --> 0:24:02.240
<v Speaker 2>of consumption, like the romanticization of mental illness today, or

0:24:02.240 --> 0:24:06.199
<v Speaker 2>the romanticization of whatever diseases we romanticize or stigmatize, like

0:24:06.560 --> 0:24:09.520
<v Speaker 2>it's all hooey. That's really important to note that, like

0:24:10.000 --> 0:24:16.840
<v Speaker 2>dying of tuberculosis is horrible and really painful, and it's

0:24:16.880 --> 0:24:19.679
<v Speaker 2>not nearly as romantic as it was made out to be.

0:24:19.960 --> 0:24:25.119
<v Speaker 1>Yeah, this ever present threat of death from tuberculosis and

0:24:25.480 --> 0:24:28.520
<v Speaker 1>everything else that was happening during in many industrialized regions

0:24:28.560 --> 0:24:32.600
<v Speaker 1>of the world during the seventeen hundreds eighteen hundreds. I

0:24:32.680 --> 0:24:34.600
<v Speaker 1>was thinking about this in the context of how people

0:24:34.680 --> 0:24:38.119
<v Speaker 1>related to their own mortality at any stage, or the

0:24:38.160 --> 0:24:42.520
<v Speaker 1>mortality of their friends and family. What did that And

0:24:42.560 --> 0:24:44.560
<v Speaker 1>I know that tuberculosis is one part of this, but

0:24:44.600 --> 0:24:48.080
<v Speaker 1>what did that look like and how did that sort

0:24:48.080 --> 0:24:52.280
<v Speaker 1>of lead to people creating these concepts or perceptions of

0:24:52.280 --> 0:24:54.040
<v Speaker 1>what an ideal death should be.

0:24:55.119 --> 0:24:59.200
<v Speaker 2>Yeah, I think tb was and remains really hard because

0:24:59.560 --> 0:25:01.720
<v Speaker 2>it it was called the robber of youth. It killed

0:25:01.720 --> 0:25:03.640
<v Speaker 2>people in the one time of life when you were

0:25:03.640 --> 0:25:06.960
<v Speaker 2>supposed to be relatively insulated from death and dying. Right

0:25:07.040 --> 0:25:09.680
<v Speaker 2>like half of all people at the time were dying

0:25:09.680 --> 0:25:12.080
<v Speaker 2>before the age of five, and then of course lots

0:25:12.080 --> 0:25:14.480
<v Speaker 2>of people were dying over the age of fifty five.

0:25:15.000 --> 0:25:18.400
<v Speaker 2>But between the ages of say ten and forty five,

0:25:18.960 --> 0:25:22.600
<v Speaker 2>you were supposed to be relatively healthy. You were supposed

0:25:22.640 --> 0:25:26.280
<v Speaker 2>to be in the prime of life, and consumption often

0:25:26.400 --> 0:25:28.520
<v Speaker 2>killed people in that prime of life, which made it

0:25:28.600 --> 0:25:31.120
<v Speaker 2>really hard to make sense of and I think especially

0:25:31.160 --> 0:25:37.280
<v Speaker 2>devastating for families. And so I'm convinced that when we

0:25:37.320 --> 0:25:40.440
<v Speaker 2>do not have an answer, we find one, we make

0:25:40.480 --> 0:25:43.880
<v Speaker 2>one up. And I remember my dad had cancer twice

0:25:43.880 --> 0:25:45.919
<v Speaker 2>when I was a little kid in the nineteen eighties,

0:25:46.440 --> 0:25:49.119
<v Speaker 2>and people would tell my dad that it was commonly

0:25:49.200 --> 0:25:51.280
<v Speaker 2>believed at the time that cancer came from bottling up

0:25:51.320 --> 0:25:53.800
<v Speaker 2>your feelings. I mean, people told my dad that, you

0:25:53.840 --> 0:25:57.399
<v Speaker 2>know that he got cancer because he hadn't been expressive

0:25:57.520 --> 0:26:01.639
<v Speaker 2>enough about his own emotions. And that's us trying to

0:26:01.680 --> 0:26:04.600
<v Speaker 2>find an explanation for the unexplainable. And I think that

0:26:04.680 --> 0:26:07.520
<v Speaker 2>happened a lot with consumption in the eighteenth and nineteenth century.

0:26:08.440 --> 0:26:10.800
<v Speaker 1>Let's take a quick break here. We'll be back before

0:26:10.800 --> 0:26:26.879
<v Speaker 1>you know it. Welcome back, everyone. I'm here chatting with

0:26:26.920 --> 0:26:30.960
<v Speaker 1>the incredible John Green about his book Everything Is Tuberculosis.

0:26:31.359 --> 0:26:35.480
<v Speaker 1>Let's get into some more questions. People have never dealt

0:26:35.480 --> 0:26:38.680
<v Speaker 1>with uncertainty or been able to sit with uncertainty. Even

0:26:38.720 --> 0:26:40.960
<v Speaker 1>if we know the mechanism of disease and how the

0:26:41.600 --> 0:26:44.600
<v Speaker 1>path of physiology, it's still there's still plenty of room

0:26:44.640 --> 0:26:48.960
<v Speaker 1>for blame and stigma and shame. And so you touched

0:26:48.960 --> 0:26:52.320
<v Speaker 1>on this a bit with a conflation of tuberculosis and whiteness.

0:26:52.840 --> 0:26:56.000
<v Speaker 1>How was the prevailing assumption of tuberculosis as like a

0:26:56.040 --> 0:27:00.280
<v Speaker 1>white man's disease shaped by colonialism and white supremacy.

0:27:00.560 --> 0:27:05.960
<v Speaker 2>Profoundly, profoundly, it was really believed by white doctors that

0:27:06.080 --> 0:27:10.359
<v Speaker 2>consumption was impossible among people of color. And this was

0:27:11.119 --> 0:27:15.200
<v Speaker 2>partly because consumption was so romanticized that it was believed

0:27:15.200 --> 0:27:17.720
<v Speaker 2>to be a disease of the great intellects, and a

0:27:17.760 --> 0:27:20.719
<v Speaker 2>disease of the very beautiful, and a disease of paleness,

0:27:20.760 --> 0:27:23.359
<v Speaker 2>and all of this stuff, and all these ideas that

0:27:23.840 --> 0:27:27.800
<v Speaker 2>we had in Europe and the United States around whiteness

0:27:29.119 --> 0:27:33.920
<v Speaker 2>penetrated our understanding of disease as well. And so, you know,

0:27:34.000 --> 0:27:39.480
<v Speaker 2>Frank Ryan writes very movingly about how tuberculosis in black

0:27:39.480 --> 0:27:42.440
<v Speaker 2>and brown people was considered to be a different disease,

0:27:42.800 --> 0:27:46.480
<v Speaker 2>a disease that was not even given a name, which speaks,

0:27:46.520 --> 0:27:50.879
<v Speaker 2>i think, both to healthcare access and to the total

0:27:51.000 --> 0:27:55.960
<v Speaker 2>racism of the medical establishment at the time. And so

0:27:56.080 --> 0:28:00.480
<v Speaker 2>until TB became understood as an infectious disease. It was

0:28:00.640 --> 0:28:05.240
<v Speaker 2>generally believed to be rare or impossible among people of color.

0:28:06.080 --> 0:28:10.040
<v Speaker 1>And then how did the discovery of microbacteria tuberculosis sort

0:28:10.040 --> 0:28:14.880
<v Speaker 1>of changed that both that aspect but also overall what

0:28:15.000 --> 0:28:17.760
<v Speaker 1>tuberculos is, you know, the romanticization and sort of now

0:28:17.840 --> 0:28:21.160
<v Speaker 1>this new othering of this disease.

0:28:21.920 --> 0:28:25.200
<v Speaker 2>Yeah, it changed everything. Once we understood that TV was infectious,

0:28:25.240 --> 0:28:29.280
<v Speaker 2>Suddenly it became a disease that was no longer romanticized

0:28:29.280 --> 0:28:33.240
<v Speaker 2>and was heavily stigmatized, associated with poverty, associated with poor

0:28:33.280 --> 0:28:38.200
<v Speaker 2>working conditions, crowded living conditions, and especially associated with people

0:28:38.240 --> 0:28:41.880
<v Speaker 2>of color. So whereas before white supremacy had held that

0:28:42.360 --> 0:28:46.120
<v Speaker 2>only white people could get this disease of civilization, now

0:28:46.160 --> 0:28:50.920
<v Speaker 2>white supremacy held that disproportionately this disease would affect quote

0:28:50.960 --> 0:28:56.760
<v Speaker 2>unquote less civilized people, and that had devastating consequences for

0:28:57.040 --> 0:29:01.160
<v Speaker 2>the way that the medical establishment treated people with TV,

0:29:01.440 --> 0:29:04.640
<v Speaker 2>for the way the medical establishment understood TV and people

0:29:04.680 --> 0:29:09.400
<v Speaker 2>of color. And even today there's still a huge disproportionate

0:29:10.160 --> 0:29:12.840
<v Speaker 2>bias toward people of color when it comes to the

0:29:12.840 --> 0:29:16.520
<v Speaker 2>burden of tuberculosis, even in rich countries, but all throughout

0:29:16.520 --> 0:29:16.920
<v Speaker 2>the world.

0:29:18.040 --> 0:29:22.240
<v Speaker 1>Yeah, I was thinking about this transitional period and tuberculosis

0:29:22.240 --> 0:29:24.560
<v Speaker 1>had such an impact, as we've talked about on art

0:29:24.600 --> 0:29:28.400
<v Speaker 1>and literature and all these different aspects of life. When

0:29:28.520 --> 0:29:32.960
<v Speaker 1>that medicalization happened, how did that, like, how quickly did

0:29:32.960 --> 0:29:37.160
<v Speaker 1>that disappear from that culture of tuberculosis.

0:29:38.400 --> 0:29:43.040
<v Speaker 2>It disappeared pretty quickly, But it disappeared as quickly as

0:29:43.080 --> 0:29:46.240
<v Speaker 2>people started to really agree that the disease was infectious,

0:29:46.240 --> 0:29:49.880
<v Speaker 2>that it wasn't hereditary. So it took a couple decades.

0:29:50.080 --> 0:29:52.120
<v Speaker 2>A number of people kind of held onto the idea

0:29:52.160 --> 0:29:55.160
<v Speaker 2>that the disease was hereditary and therefore that this idea

0:29:55.160 --> 0:30:00.360
<v Speaker 2>of the tubercular personality still should hold sway. But as

0:30:01.000 --> 0:30:03.760
<v Speaker 2>it became clearer and clearer and the evidence mounted that

0:30:03.800 --> 0:30:06.920
<v Speaker 2>this is actually an infectious disease, that started to melt away.

0:30:07.200 --> 0:30:09.239
<v Speaker 2>And you can almost see it in the language, like

0:30:09.280 --> 0:30:12.840
<v Speaker 2>before eighteen eighty two, consumption is almost always referred to

0:30:12.840 --> 0:30:16.040
<v Speaker 2>as consumption, and after eighteen eighty two, it's almost always

0:30:16.040 --> 0:30:19.200
<v Speaker 2>referred to as tuberculosis. So you see the medicalization of

0:30:19.240 --> 0:30:22.440
<v Speaker 2>it even in the language that we use to describe

0:30:22.480 --> 0:30:25.160
<v Speaker 2>the illness, almost as if they're two different illnesses. Because

0:30:25.160 --> 0:30:26.560
<v Speaker 2>they're imagined so differently.

0:30:27.000 --> 0:30:29.360
<v Speaker 1>Yeah, it is. It is sort of like, yeah, this

0:30:29.800 --> 0:30:33.320
<v Speaker 1>romantic disease to this horror that is tuberculosis.

0:30:33.840 --> 0:30:37.600
<v Speaker 2>And there is something inherently horrific about infectious disease, right, Like,

0:30:37.640 --> 0:30:41.240
<v Speaker 2>there's something terrifying about the idea that we can survive

0:30:41.360 --> 0:30:44.560
<v Speaker 2>lions and bears and tigers and make all of them

0:30:45.080 --> 0:30:49.120
<v Speaker 2>irrelevant to our safety, but we can't survive these tiny

0:30:49.160 --> 0:30:52.160
<v Speaker 2>micro organisms that spread through the air. I mean that

0:30:52.400 --> 0:30:54.920
<v Speaker 2>is the stuff of a literal horror movie.

0:30:55.080 --> 0:31:00.960
<v Speaker 1>Yep, yeah, absolutely no, it's that period of seeing finally

0:31:01.200 --> 0:31:04.200
<v Speaker 1>these things and making a connection is fascinating to think

0:31:04.240 --> 0:31:07.720
<v Speaker 1>about how we perceived a cause of disease. But so

0:31:07.840 --> 0:31:11.760
<v Speaker 1>this medicalization, this discovery of the fact that tuberculosis was

0:31:11.800 --> 0:31:15.000
<v Speaker 1>caused by bacterium, this led to a lot of stigma,

0:31:15.120 --> 0:31:18.640
<v Speaker 1>and that stigma is in large part still present today

0:31:19.000 --> 0:31:20.920
<v Speaker 1>very much. And so can you talk a little bit

0:31:20.960 --> 0:31:24.240
<v Speaker 1>about that. You know, what happens when someone is diagnosed.

0:31:24.280 --> 0:31:28.040
<v Speaker 1>How might friends or family or the community broadly respond

0:31:28.120 --> 0:31:30.320
<v Speaker 1>to someone's diagnosis with tuberculosis.

0:31:31.040 --> 0:31:33.360
<v Speaker 2>Yeah, so in a different age, in a different time,

0:31:34.000 --> 0:31:37.240
<v Speaker 2>someone like Henry would have been really lifted up for

0:31:37.280 --> 0:31:41.680
<v Speaker 2>having TB right, I mean, he writes poetry. He's a

0:31:41.880 --> 0:31:48.320
<v Speaker 2>very engaged, sensitive kid, and he embodied that idea of

0:31:48.320 --> 0:31:52.720
<v Speaker 2>the tubercular personality. And if we'd had an inherited genetic

0:31:52.760 --> 0:31:55.640
<v Speaker 2>model for TB, he would have very much fit into

0:31:55.720 --> 0:31:59.920
<v Speaker 2>that romanticization of the disease. But because he got to

0:32:00.160 --> 0:32:02.760
<v Speaker 2>be in a different time in place, he was instead

0:32:02.880 --> 0:32:07.880
<v Speaker 2>hugely stigmatized. It's very common for people who have TB

0:32:08.040 --> 0:32:10.680
<v Speaker 2>to be dropped off at the hospital and completely abandoned

0:32:10.680 --> 0:32:12.960
<v Speaker 2>by their families, in some cases to never see their

0:32:12.960 --> 0:32:15.880
<v Speaker 2>families again. One of the most heartbreaking things I've heard

0:32:15.920 --> 0:32:20.440
<v Speaker 2>from nurses working in TB hospitals is how they often

0:32:20.560 --> 0:32:24.760
<v Speaker 2>have to be the only person at the funeral for

0:32:24.840 --> 0:32:28.560
<v Speaker 2>someone who dies of TB, where that person is buried

0:32:28.600 --> 0:32:31.640
<v Speaker 2>alone and the nurse or the nurses are the only

0:32:31.720 --> 0:32:36.240
<v Speaker 2>people who are there. And you know that's because TB

0:32:36.400 --> 0:32:38.920
<v Speaker 2>is seen as a disease of poverty. It's sometimes seen

0:32:38.960 --> 0:32:42.720
<v Speaker 2>as a disease of demon possession, even a disease that's

0:32:42.720 --> 0:32:46.160
<v Speaker 2>associated with all kinds of wrongly I think it's safe

0:32:46.160 --> 0:32:50.080
<v Speaker 2>to say associated with all kinds of moral failings, and

0:32:51.480 --> 0:32:55.680
<v Speaker 2>so it's really a hugely stigmatizing experience Henry talks about

0:32:56.760 --> 0:32:58.680
<v Speaker 2>in a memoir that he wrote. He talks about the

0:32:58.720 --> 0:33:03.479
<v Speaker 2>experience of being abandoned by his cousins, being abandoned by

0:33:03.520 --> 0:33:06.760
<v Speaker 2>his friends. He was very fortunate not to be abandoned

0:33:06.800 --> 0:33:09.160
<v Speaker 2>by his mother. So his mother I saw to stayed

0:33:09.160 --> 0:33:12.040
<v Speaker 2>incredibly close to him, visited him almost every day for

0:33:12.760 --> 0:33:16.480
<v Speaker 2>three years while he was hospitalized, and that made a

0:33:16.560 --> 0:33:21.640
<v Speaker 2>huge difference in his life. But for many people that's

0:33:21.680 --> 0:33:22.800
<v Speaker 2>not the norm, I think it's.

0:33:22.720 --> 0:33:27.280
<v Speaker 1>Safe to say, which is just utterly heartbreaking. I mean,

0:33:27.400 --> 0:33:31.320
<v Speaker 1>especially given that the stigmatizing, isolating disease is one that

0:33:31.360 --> 0:33:35.560
<v Speaker 1>we've had effective treatments for since the nineteen fifties. How

0:33:35.560 --> 0:33:39.800
<v Speaker 1>did the development of those treatments change the perception of tuberculosis.

0:33:40.440 --> 0:33:42.720
<v Speaker 2>Yeah, so it went from being a death sentence to

0:33:42.760 --> 0:33:46.000
<v Speaker 2>suddenly being a curable disease. I read a number of

0:33:46.040 --> 0:33:50.120
<v Speaker 2>memoirs from people who lived in sanatoria. At the height

0:33:50.200 --> 0:33:53.360
<v Speaker 2>of the TB crisis in the United States in the

0:33:53.400 --> 0:33:57.040
<v Speaker 2>early nineteen hundreds, there were almost as many hospital beds

0:33:57.040 --> 0:34:00.000
<v Speaker 2>for TV patients as there were for all other causes combined,

0:34:00.000 --> 0:34:04.800
<v Speaker 2>and there were hundreds of these sanatoria around the country.

0:34:04.800 --> 0:34:07.960
<v Speaker 2>There were cities like Asheville, North Carolina, Pasadena, California, that

0:34:08.000 --> 0:34:13.360
<v Speaker 2>were essentially founded as tuberculosis colonies, and all of a sudden,

0:34:13.400 --> 0:34:16.080
<v Speaker 2>these places just emptied out. I mean, you read about

0:34:16.160 --> 0:34:20.600
<v Speaker 2>these people who lived in sanatoria. I read one memoir

0:34:20.640 --> 0:34:23.160
<v Speaker 2>by a woman who lived in a sanatorium from the

0:34:23.200 --> 0:34:26.640
<v Speaker 2>age of three until she was seventeen and suddenly strepped

0:34:26.680 --> 0:34:28.439
<v Speaker 2>to micin made it so that she could go home,

0:34:29.040 --> 0:34:30.880
<v Speaker 2>and she didn't even remember what it was like to

0:34:30.920 --> 0:34:34.600
<v Speaker 2>be lovingly touched. She didn't remember what it was like

0:34:34.719 --> 0:34:38.799
<v Speaker 2>to be with friends and family, be in that kind

0:34:38.800 --> 0:34:42.719
<v Speaker 2>of like loud, boisterous environment of a home. But for

0:34:42.840 --> 0:34:45.879
<v Speaker 2>many millions of people that was the case. I mean,

0:34:46.480 --> 0:34:51.600
<v Speaker 2>the antibiotic era really dramatically reduced the burden of TV,

0:34:51.800 --> 0:34:54.760
<v Speaker 2>but it also made it so that we imagined TV differently.

0:34:54.800 --> 0:34:59.240
<v Speaker 2>Instead of being an incurable, chronic, terrifying condition, it became

0:34:59.320 --> 0:35:01.680
<v Speaker 2>something that we know how to cure. The problem is

0:35:01.719 --> 0:35:06.400
<v Speaker 2>that in many communities it remained an incurable chronic condition.

0:35:07.400 --> 0:35:10.000
<v Speaker 1>And simply due to lack of access. And I think

0:35:10.000 --> 0:35:12.239
<v Speaker 1>that we have a tendency, or at least here in

0:35:12.280 --> 0:35:14.600
<v Speaker 1>the US, we have a tendency to think of like, oh,

0:35:14.920 --> 0:35:17.239
<v Speaker 1>we solved that, we figured that out. Going back to

0:35:17.280 --> 0:35:20.680
<v Speaker 1>that Charles Dickens quote of tuberculosis as the great leveler.

0:35:21.120 --> 0:35:24.680
<v Speaker 1>But we see these patterns of disease and tuberculosis on

0:35:24.719 --> 0:35:27.520
<v Speaker 1>a global scale that really show that it's not the

0:35:27.680 --> 0:35:30.960
<v Speaker 1>disease that wealth never warded off anymore. What are these

0:35:31.000 --> 0:35:33.799
<v Speaker 1>patterns that we see and how do they kind of

0:35:33.800 --> 0:35:36.480
<v Speaker 1>reveal global priorities in public health?

0:35:37.520 --> 0:35:39.600
<v Speaker 2>I mean, the pattern that we see is the pattern

0:35:39.640 --> 0:35:43.239
<v Speaker 2>that you identified at the beginning of this conversation, which

0:35:43.280 --> 0:35:46.200
<v Speaker 2>is that since TB became curable, we let one hundred

0:35:46.200 --> 0:35:48.480
<v Speaker 2>and fifty million people die of it. Yeah, I mean

0:35:48.520 --> 0:35:53.000
<v Speaker 2>probably more than that. That's a conservative estimate, and we

0:35:53.600 --> 0:35:57.960
<v Speaker 2>have done that because of systems of resource distribution and

0:35:58.760 --> 0:36:03.120
<v Speaker 2>where we allocate our resources. I have to tell you

0:36:03.280 --> 0:36:06.120
<v Speaker 2>as we're recording this, I just received a message from

0:36:06.360 --> 0:36:10.080
<v Speaker 2>my friend Attol Gawande, who was the head of Global

0:36:10.080 --> 0:36:14.520
<v Speaker 2>health at USAID and saying that there are boxes of

0:36:14.560 --> 0:36:19.719
<v Speaker 2>TV medication right now rotting in warehouses waiting to be distributed,

0:36:19.760 --> 0:36:22.719
<v Speaker 2>and there's no way to distribute them. And that's the

0:36:22.800 --> 0:36:27.040
<v Speaker 2>kind of thing that we have seen really for decades

0:36:27.160 --> 0:36:31.600
<v Speaker 2>on various levels. You know, we've seen sometimes there are

0:36:32.000 --> 0:36:36.600
<v Speaker 2>systematic attempts to get tuberculosis treatment to lots of people.

0:36:37.080 --> 0:36:40.600
<v Speaker 2>A lot of times those attempts are very haphazard and consistent.

0:36:41.800 --> 0:36:47.400
<v Speaker 2>They are you know, funded by small nonprofits or by individuals,

0:36:47.520 --> 0:36:50.759
<v Speaker 2>and you know, not in a way that's long term

0:36:50.760 --> 0:36:53.960
<v Speaker 2>sustainable or can deal with the size of the crisis

0:36:53.960 --> 0:36:57.400
<v Speaker 2>that we face. And tb anywhere is a threat to

0:36:57.400 --> 0:36:59.920
<v Speaker 2>people everywhere. I mean, I think it's really important to

0:37:00.120 --> 0:37:02.520
<v Speaker 2>acknowledge that, Like, yes, we have dealt with TV in

0:37:02.560 --> 0:37:05.560
<v Speaker 2>the United States, but we have had a TV outbreak

0:37:05.760 --> 0:37:09.400
<v Speaker 2>in Kansas earlier this year. We have over ten thousand

0:37:09.480 --> 0:37:12.600
<v Speaker 2>cases of active tuberculosis every year in the United States

0:37:12.640 --> 0:37:15.919
<v Speaker 2>and probably over one hundred thousand cases of latent TV

0:37:16.080 --> 0:37:19.120
<v Speaker 2>that we don't always identify, and so it's a truly

0:37:19.200 --> 0:37:22.439
<v Speaker 2>global problem. Now it's very rare to die of tuberculosis

0:37:22.440 --> 0:37:25.440
<v Speaker 2>in the United States because people can generally access healthcare,

0:37:25.920 --> 0:37:30.000
<v Speaker 2>but it does happen. And as if we continue to

0:37:30.120 --> 0:37:34.800
<v Speaker 2>let this disease spread among millions of people every year

0:37:35.719 --> 0:37:39.960
<v Speaker 2>and we're inconsistent with treatment regimens, we are allowing the

0:37:40.000 --> 0:37:43.520
<v Speaker 2>disease to have millions and millions of opportunities to evolve

0:37:43.560 --> 0:37:46.120
<v Speaker 2>further resistance to the tools that we have to fight it.

0:37:46.160 --> 0:37:48.360
<v Speaker 2>And because we haven't done a good job of inventing

0:37:48.440 --> 0:37:52.120
<v Speaker 2>new tools over the last sixty years, that's a real issue.

0:37:52.320 --> 0:37:56.640
<v Speaker 1>Yeah, I mean truly, and I appreciate that the global

0:37:56.680 --> 0:37:59.000
<v Speaker 1>perspective of sort of how all of these things are

0:37:59.000 --> 0:38:02.359
<v Speaker 1>playing together, and I want to kind of narrow in

0:38:02.400 --> 0:38:05.799
<v Speaker 1>on Sierra Leone specifically to connect the dots between all

0:38:05.840 --> 0:38:08.920
<v Speaker 1>of these different factors that contribute to people, you know,

0:38:09.160 --> 0:38:13.200
<v Speaker 1>developing tuberculosis and then not receiving the care that they

0:38:13.200 --> 0:38:16.000
<v Speaker 1>should be receiving. And there's you know, there's healthcare infrastructure,

0:38:16.040 --> 0:38:19.680
<v Speaker 1>there's funding inconsistency, there's an overall lack of access. Can

0:38:19.719 --> 0:38:21.440
<v Speaker 1>you sort of help me connect to the dots for

0:38:21.520 --> 0:38:24.600
<v Speaker 1>how all of these things lead to tuberculosis as the

0:38:24.680 --> 0:38:25.240
<v Speaker 1>end result.

0:38:25.760 --> 0:38:28.520
<v Speaker 2>Yeah, I think that's exactly right. You have to understand

0:38:28.520 --> 0:38:32.760
<v Speaker 2>this in historical context. We have to understand that tuberculosis

0:38:32.760 --> 0:38:35.960
<v Speaker 2>did not just arrive in Sierra Leone. It did not

0:38:36.120 --> 0:38:38.920
<v Speaker 2>just like show up in Henry one day. This happened

0:38:38.960 --> 0:38:42.840
<v Speaker 2>because of a series of historical events and historical forces

0:38:42.840 --> 0:38:44.719
<v Speaker 2>that go back for centuries. That go back to the

0:38:44.719 --> 0:38:49.239
<v Speaker 2>Transatlantic slave trade, in colonialism and the extraction of resources

0:38:49.280 --> 0:38:53.560
<v Speaker 2>from Sierra Leone's economy, and so many other factors. But

0:38:54.000 --> 0:38:59.200
<v Speaker 2>you know, Henry in the end got sick because TB

0:38:59.760 --> 0:39:04.799
<v Speaker 2>has been allowed to thrive in Sierra Leone for the

0:39:04.880 --> 0:39:08.720
<v Speaker 2>last several hundred years and has been allowed to thrive

0:39:08.920 --> 0:39:12.799
<v Speaker 2>since we developed tools to fight it. Henry developed drug

0:39:12.880 --> 0:39:16.880
<v Speaker 2>resistant tuberculosis, and so for someone like him, treatment is

0:39:17.000 --> 0:39:20.799
<v Speaker 2>very difficult. Not because it's impossible or because it's the

0:39:20.840 --> 0:39:22.480
<v Speaker 2>treatment is made of gold, or we have to go

0:39:22.520 --> 0:39:25.200
<v Speaker 2>to the moon to get it or something, but because

0:39:25.440 --> 0:39:29.600
<v Speaker 2>the global health system thinks of tuberculosis as being very

0:39:29.640 --> 0:39:33.160
<v Speaker 2>expensive to treat, and especially of drug resistant tuberculosis as

0:39:33.200 --> 0:39:36.240
<v Speaker 2>being very expensive to treat. Now that's starting to change.

0:39:36.239 --> 0:39:39.600
<v Speaker 2>But when Henry got sick in twenty eighteen, when he

0:39:39.760 --> 0:39:43.040
<v Speaker 2>first was really diagnosed with drug resistant tuberculosis and became

0:39:43.200 --> 0:39:46.480
<v Speaker 2>very very ill, there were very few options available to

0:39:46.520 --> 0:39:49.080
<v Speaker 2>people like him in a country like Sierra Leone. If

0:39:49.120 --> 0:39:52.680
<v Speaker 2>I'd gotten the exact same strain of drug resistant tuberculosis

0:39:52.760 --> 0:39:55.040
<v Speaker 2>at the exact same time, I would have received an

0:39:55.040 --> 0:39:58.720
<v Speaker 2>immediate molecular test to identify not just whether I had TV,

0:39:58.880 --> 0:40:02.160
<v Speaker 2>but which antibiotics my TV would respond to. I would

0:40:02.160 --> 0:40:04.440
<v Speaker 2>have been put on appropriate treatment immediately. I would have

0:40:04.440 --> 0:40:07.719
<v Speaker 2>been isolated, and within a few months I would have

0:40:07.719 --> 0:40:09.880
<v Speaker 2>been able to go home, and within a year I

0:40:09.920 --> 0:40:13.040
<v Speaker 2>would have been healthy and cured. But that wasn't the

0:40:13.080 --> 0:40:16.840
<v Speaker 2>case for Henry. Henry had to go to Leaca, to

0:40:16.880 --> 0:40:20.560
<v Speaker 2>this tuberculosis hospital and he had to be put on

0:40:20.600 --> 0:40:24.160
<v Speaker 2>second line antibiotics, which it turned out didn't work. And

0:40:24.200 --> 0:40:26.360
<v Speaker 2>we would have known that they wouldn't work if he

0:40:26.360 --> 0:40:29.360
<v Speaker 2>could have afforded that molecular test, but they weren't available

0:40:29.360 --> 0:40:30.200
<v Speaker 2>in sierily.

0:40:29.920 --> 0:40:33.239
<v Speaker 1>On at the time. Yeah. And so you mentioned that

0:40:33.280 --> 0:40:37.120
<v Speaker 1>Henry had a drug resistant form of tuberculosis, and one

0:40:37.120 --> 0:40:40.240
<v Speaker 1>of the primary reasons cited for the rise and spread

0:40:40.320 --> 0:40:44.520
<v Speaker 1>of drug resistant tuberculosis is patient on compliance. But there

0:40:44.600 --> 0:40:47.759
<v Speaker 1>is so much more nuance to that term patient non

0:40:47.760 --> 0:40:50.839
<v Speaker 1>compliance that I really appreciate that you went into in

0:40:50.880 --> 0:40:55.520
<v Speaker 1>your book and this how this term unfairly places blame

0:40:55.640 --> 0:40:59.200
<v Speaker 1>and burden entirely on the patient without examining the reasons

0:40:59.520 --> 0:41:03.040
<v Speaker 1>for non compliance. So can you sort of, you know,

0:41:03.160 --> 0:41:05.760
<v Speaker 1>talk a little bit more about that and this nuance

0:41:05.840 --> 0:41:07.840
<v Speaker 1>with non compliance sure.

0:41:07.920 --> 0:41:10.960
<v Speaker 2>Well, first off, if you receive a seven day treatment

0:41:11.400 --> 0:41:14.279
<v Speaker 2>of antibiotics to cure strep throat and you take it

0:41:14.320 --> 0:41:17.560
<v Speaker 2>for six days, you're technically a non compliant patient. So

0:41:17.800 --> 0:41:19.279
<v Speaker 2>just bare that in mind. I mean, how many of

0:41:19.320 --> 0:41:21.840
<v Speaker 2>us have you know, not taken that last day of

0:41:21.840 --> 0:41:26.239
<v Speaker 2>antibiotics because we felt better. Well, imagine having to take

0:41:26.920 --> 0:41:30.399
<v Speaker 2>dozens of pills every day for four months, or six

0:41:30.480 --> 0:41:32.960
<v Speaker 2>months or a year that make you very sick, that

0:41:33.000 --> 0:41:36.439
<v Speaker 2>have side effects that you don't like. That's one thing

0:41:36.480 --> 0:41:39.640
<v Speaker 2>to consider. But then also I remember once I was

0:41:39.640 --> 0:41:42.839
<v Speaker 2>in Sierra Leone and I was making a home visit

0:41:42.880 --> 0:41:45.440
<v Speaker 2>with a doctor and a community health worker, and the

0:41:45.440 --> 0:41:49.040
<v Speaker 2>community health worker asked the young patient, have you been

0:41:49.080 --> 0:41:51.520
<v Speaker 2>able to take your TV meds today? And she said, no,

0:41:51.600 --> 0:41:53.399
<v Speaker 2>I don't have any food, and if I take them

0:41:53.400 --> 0:41:55.799
<v Speaker 2>without food, I just throw up. I just throw them

0:41:55.880 --> 0:41:58.920
<v Speaker 2>up immediately. And so the doctor said, well, you know,

0:41:59.080 --> 0:42:01.359
<v Speaker 2>sometimes if you pour a little bit of sugar into

0:42:01.400 --> 0:42:03.520
<v Speaker 2>your water, it can settle your stomach a little and

0:42:03.560 --> 0:42:05.560
<v Speaker 2>allow you to take the medication. And that was the

0:42:05.600 --> 0:42:07.719
<v Speaker 2>only thing that he was able to say to her

0:42:07.840 --> 0:42:12.520
<v Speaker 2>because there were no resources to buy her food in

0:42:12.560 --> 0:42:17.120
<v Speaker 2>that moment. And so is that a non compliant patient?

0:42:17.560 --> 0:42:21.480
<v Speaker 2>I mean, if you throw up immediately after taking your

0:42:21.520 --> 0:42:23.680
<v Speaker 2>medication because you don't have access to food, are you

0:42:23.719 --> 0:42:26.680
<v Speaker 2>a non compliant patient? Are you a non compliant patient

0:42:26.719 --> 0:42:29.640
<v Speaker 2>if you can't afford the transportation to get to the

0:42:29.640 --> 0:42:33.759
<v Speaker 2>clinic every single day? Because still often patients have to

0:42:33.760 --> 0:42:37.200
<v Speaker 2>be physically observed, it's called directly observed therapy. They have

0:42:37.239 --> 0:42:40.160
<v Speaker 2>to be physically observed taking their medication every single day

0:42:40.200 --> 0:42:44.600
<v Speaker 2>to make sure that they're quote unquote compliant. But that

0:42:44.760 --> 0:42:47.880
<v Speaker 2>the burden of having to get to a healthcare facility

0:42:47.920 --> 0:42:52.480
<v Speaker 2>every day, affording transportation, affording childcare, whatever the complexities are

0:42:52.520 --> 0:42:56.040
<v Speaker 2>in your particular life, that burden is often overwhelming for people.

0:42:56.320 --> 0:42:58.520
<v Speaker 2>So there are a number of reasons why people might

0:42:58.560 --> 0:43:02.839
<v Speaker 2>be deemed non compliant or deemed loss to follow up,

0:43:02.880 --> 0:43:07.839
<v Speaker 2>which is another phrase I find horrifying. And we have

0:43:07.880 --> 0:43:10.160
<v Speaker 2>to make space for the healthcare system to meet the

0:43:10.200 --> 0:43:13.400
<v Speaker 2>needs of patients rather than requiring patients to meet the

0:43:13.440 --> 0:43:16.839
<v Speaker 2>needs of the healthcare system. We do a bad job

0:43:16.880 --> 0:43:18.239
<v Speaker 2>of that everywhere. I mean, I don't think we do

0:43:18.280 --> 0:43:20.080
<v Speaker 2>a particularly good job of it in the United States.

0:43:20.120 --> 0:43:23.000
<v Speaker 2>I know that, like I struggle sometimes to get access

0:43:23.080 --> 0:43:25.000
<v Speaker 2>to mental health care that I need, even though I

0:43:25.040 --> 0:43:29.439
<v Speaker 2>have lots of resources available to me. But I think

0:43:29.800 --> 0:43:31.400
<v Speaker 2>we need to do a much better job of it,

0:43:31.520 --> 0:43:33.160
<v Speaker 2>especially in impoverished communities.

0:43:33.719 --> 0:43:36.800
<v Speaker 1>The way that so many people with tuberculosis are treated

0:43:36.840 --> 0:43:39.600
<v Speaker 1>just shows this lack of trust in them as individuals

0:43:39.640 --> 0:43:41.919
<v Speaker 1>who also want to they don't want to be sick

0:43:41.960 --> 0:43:44.919
<v Speaker 1>with this, Like it just sort of is that non

0:43:44.960 --> 0:43:48.319
<v Speaker 1>compliance term really kind of has these connotations of like, well,

0:43:48.360 --> 0:43:50.399
<v Speaker 1>they just don't care enough. It's like, of course they do.

0:43:51.239 --> 0:43:55.440
<v Speaker 1>How could that be the conclusion, yeah right, yeah.

0:43:55.239 --> 0:43:57.799
<v Speaker 2>Right, Or that they're somehow like not dedicated, they're not

0:43:57.880 --> 0:44:01.040
<v Speaker 2>adequately you know, they're not out of quickly hard working

0:44:01.760 --> 0:44:04.000
<v Speaker 2>or committed to their own health or whatever. But like,

0:44:04.760 --> 0:44:07.960
<v Speaker 2>you know, first off, lots of people struggled to take

0:44:07.960 --> 0:44:10.600
<v Speaker 2>their medication. I struggled to take my medication. I don't

0:44:10.600 --> 0:44:12.200
<v Speaker 2>know exactly why. I think some of it has to

0:44:12.200 --> 0:44:14.640
<v Speaker 2>do with stigma, with this idea that you know, somehow

0:44:14.640 --> 0:44:18.280
<v Speaker 2>I'm less I take medication to treat OCD in major depression.

0:44:18.320 --> 0:44:20.800
<v Speaker 2>And some of it has to do with this idea

0:44:20.800 --> 0:44:25.120
<v Speaker 2>that somehow, like I'm less whole or self sufficient or

0:44:25.160 --> 0:44:28.440
<v Speaker 2>complete or whatever. If I need medication in order to

0:44:28.800 --> 0:44:31.759
<v Speaker 2>be myself or in order to be well, some of

0:44:31.800 --> 0:44:35.719
<v Speaker 2>it has to do with the burden of getting the medication,

0:44:36.120 --> 0:44:38.719
<v Speaker 2>you know, And my burden of getting the medication is

0:44:39.080 --> 0:44:41.320
<v Speaker 2>just calling up the pharmacy and getting a refill. It

0:44:41.360 --> 0:44:43.600
<v Speaker 2>couldn't be easier for me. And yet still like that

0:44:43.680 --> 0:44:47.200
<v Speaker 2>barrier sometimes feels overwhelming to me. And then you have

0:44:47.239 --> 0:44:49.960
<v Speaker 2>to remember that a lot of people living with tuberculosis

0:44:50.000 --> 0:44:53.799
<v Speaker 2>are also living with other health problems, including severe mental

0:44:53.800 --> 0:44:56.400
<v Speaker 2>health problems. I remember meeting with a young man who'd

0:44:56.440 --> 0:44:59.560
<v Speaker 2>been completely abandoned by his family, who struggled to take

0:44:59.560 --> 0:45:02.719
<v Speaker 2>his medicaation, who'd been abandoned by his friends, who was

0:45:02.800 --> 0:45:06.000
<v Speaker 2>utterly alone in the world, who felt absolutely hopeless, who

0:45:06.080 --> 0:45:10.799
<v Speaker 2>was you know, consumed by depression. And you know, we're

0:45:11.160 --> 0:45:14.400
<v Speaker 2>asking this person to make his way to a clinic

0:45:14.440 --> 0:45:16.360
<v Speaker 2>every day so that he can take his medication. Like

0:45:16.440 --> 0:45:18.120
<v Speaker 2>that's that's asking a lot.

0:45:18.480 --> 0:45:21.160
<v Speaker 1>Yeah, I think these are these are aspects that aren't

0:45:21.160 --> 0:45:24.520
<v Speaker 1>don't always come out in medical literature unless it's about

0:45:24.560 --> 0:45:28.640
<v Speaker 1>this specific you know, the context of non compliance and

0:45:28.680 --> 0:45:31.560
<v Speaker 1>what that what that actually reveals, given that some of

0:45:31.600 --> 0:45:35.719
<v Speaker 1>this awful side effects of these tuberculosis medications. Seems like

0:45:35.760 --> 0:45:39.959
<v Speaker 1>one way to overcome this would be to develop new

0:45:40.040 --> 0:45:44.359
<v Speaker 1>drugs for the disease. Yet, as you discuss, very few

0:45:44.360 --> 0:45:48.680
<v Speaker 1>tuberculosis drugs have been developed in recent years, and these

0:45:48.760 --> 0:45:53.440
<v Speaker 1>newer drugs even are prohibitively expensive despite mostly being funded with,

0:45:53.520 --> 0:45:56.319
<v Speaker 1>you know, with public funds. So what are some of

0:45:56.320 --> 0:45:59.640
<v Speaker 1>the ways that people are working on this problem.

0:46:00.400 --> 0:46:02.640
<v Speaker 2>Yeah, So this is a place of encouragement for me,

0:46:02.719 --> 0:46:05.640
<v Speaker 2>And I'm sorry if this has been a largely discouraging conversation,

0:46:05.800 --> 0:46:07.759
<v Speaker 2>but this really is a place of encouragement for me.

0:46:07.880 --> 0:46:11.480
<v Speaker 2>Between nineteen forty four and nineteen sixty five, we developed

0:46:11.640 --> 0:46:14.600
<v Speaker 2>something like eight classes of drugs to treat tuberculosis, and

0:46:14.600 --> 0:46:17.920
<v Speaker 2>then between nineteen sixty six and twenty twelve we developed none.

0:46:18.920 --> 0:46:22.040
<v Speaker 2>And all those years we could have been developing great

0:46:22.040 --> 0:46:24.400
<v Speaker 2>tools to treat TB, but we didn't because the profit

0:46:24.480 --> 0:46:29.600
<v Speaker 2>motive wasn't there. Now, and some of this has become

0:46:29.800 --> 0:46:34.680
<v Speaker 2>complicated of late, but now there are more mechanisms in

0:46:34.719 --> 0:46:37.719
<v Speaker 2>place to try to incentivize the creation of anti TB

0:46:37.920 --> 0:46:41.759
<v Speaker 2>drugs and drugs in general that I consider diseases of injustice,

0:46:41.800 --> 0:46:47.000
<v Speaker 2>diseases that are caused not primarily by whatever the pathogen is,

0:46:47.040 --> 0:46:52.360
<v Speaker 2>but really by human choice, by human built systems, like tuberculosis,

0:46:52.480 --> 0:46:57.400
<v Speaker 2>like cholera I think is another great example. Typhoid's a

0:46:57.400 --> 0:47:01.120
<v Speaker 2>good example. Malaria is one of the big examples. In

0:47:01.160 --> 0:47:05.160
<v Speaker 2>the twenty first century. All those diseases, I think they

0:47:05.160 --> 0:47:08.280
<v Speaker 2>still don't receive nearly the amount of attention that they should,

0:47:08.440 --> 0:47:11.200
<v Speaker 2>nearly the funding that they should, but they receive more funding.

0:47:11.280 --> 0:47:13.480
<v Speaker 2>And so in the last ten or twelve years, we've

0:47:13.480 --> 0:47:17.160
<v Speaker 2>developed some powerful new medications to treat TB, including bedaculin

0:47:17.239 --> 0:47:21.040
<v Speaker 2>and dilaminid, which are really good drugs. Now, as you

0:47:21.080 --> 0:47:26.239
<v Speaker 2>point out, they have historically been too expensive, and so

0:47:26.760 --> 0:47:29.719
<v Speaker 2>we're using a lot of times second line antibiotics that

0:47:29.760 --> 0:47:32.080
<v Speaker 2>are from the sixties that we know aren't very good

0:47:32.120 --> 0:47:34.840
<v Speaker 2>and that are highly toxic, that can cause total hearing

0:47:34.920 --> 0:47:36.839
<v Speaker 2>loss and up to twenty percent of people who take

0:47:36.880 --> 0:47:41.360
<v Speaker 2>them lots of other adverse effects. But we're starting to

0:47:41.400 --> 0:47:44.840
<v Speaker 2>see the better regimens roll out and more encouraging. Still,

0:47:45.000 --> 0:47:47.200
<v Speaker 2>the amount of time that people need to be treated

0:47:47.200 --> 0:47:50.560
<v Speaker 2>for tuberculosis is going down, so we're starting to see

0:47:50.600 --> 0:47:53.360
<v Speaker 2>the NTB trials, which were funded by partners in health

0:47:53.400 --> 0:47:58.160
<v Speaker 2>and doctors without borders. Those saw that we can cure

0:47:58.200 --> 0:48:00.719
<v Speaker 2>TB in less time than we thought we could, and

0:48:01.320 --> 0:48:04.799
<v Speaker 2>that's encouraging. So I think we have better tools than ever.

0:48:04.920 --> 0:48:07.200
<v Speaker 2>We have better diagnostic tools than ever. We're on the

0:48:07.239 --> 0:48:10.080
<v Speaker 2>cusp of maybe having a tongue swab test for TV

0:48:10.239 --> 0:48:13.440
<v Speaker 2>that would be game changing and very inexpensive. We have

0:48:13.480 --> 0:48:16.200
<v Speaker 2>better drugs than ever, we have shorter regimens than ever,

0:48:16.640 --> 0:48:19.240
<v Speaker 2>and on all those fronts we are starting to see

0:48:19.360 --> 0:48:21.480
<v Speaker 2>real progress in the last ten years.

0:48:21.760 --> 0:48:26.160
<v Speaker 1>Yeah, that is really encouraging, and I think that it's

0:48:26.200 --> 0:48:29.080
<v Speaker 1>easy to get wrapped up in all of that. The

0:48:29.200 --> 0:48:31.480
<v Speaker 1>challenge is ahead of us, but it is so important

0:48:31.520 --> 0:48:33.720
<v Speaker 1>to remember that there are people who are doing really

0:48:33.800 --> 0:48:36.840
<v Speaker 1>excellent work and really trying to change things when it

0:48:36.840 --> 0:48:39.920
<v Speaker 1>comes to the way that we treat and deal with tuberculosis,

0:48:39.960 --> 0:48:43.839
<v Speaker 1>and these sustained improvements that we would be able to

0:48:43.840 --> 0:48:47.280
<v Speaker 1>make when it comes to tuberculosis, you know, requires investment

0:48:47.360 --> 0:48:50.840
<v Speaker 1>in healthcare infrastructure, in treatment and early detection and active

0:48:50.880 --> 0:48:54.920
<v Speaker 1>case finding. And if we did a better job with tuberculosis,

0:48:54.960 --> 0:48:56.880
<v Speaker 1>that would be money saving in the long run, like

0:48:56.920 --> 0:49:00.080
<v Speaker 1>tremendously so, and I hate could always bring it to money.

0:49:00.120 --> 0:49:02.760
<v Speaker 1>But that is such a crucial part of every single

0:49:02.800 --> 0:49:07.160
<v Speaker 1>like public health decision. Why does that calculation not seem

0:49:07.239 --> 0:49:08.200
<v Speaker 1>to matter.

0:49:09.040 --> 0:49:12.360
<v Speaker 2>Every dollar we invest in TV brings forty dollars in

0:49:12.520 --> 0:49:15.520
<v Speaker 2>future health benefits, And every time we end a chain

0:49:15.560 --> 0:49:17.880
<v Speaker 2>of transmission of TV, it means less TB in the world.

0:49:17.920 --> 0:49:20.759
<v Speaker 2>You know, TB is a curable disease, which means that

0:49:20.800 --> 0:49:23.239
<v Speaker 2>we could eliminate it. We could live in a world

0:49:23.280 --> 0:49:25.759
<v Speaker 2>without TV. If you think about how much we used

0:49:25.800 --> 0:49:28.040
<v Speaker 2>to spend on tuberculosis in the United States, when we

0:49:28.080 --> 0:49:31.000
<v Speaker 2>had seven hundred thousand hospital beds devoted to the disease,

0:49:31.400 --> 0:49:33.520
<v Speaker 2>and how much we spend on it now, you see

0:49:33.520 --> 0:49:36.239
<v Speaker 2>that impact right Like you can just see it intuitively

0:49:36.320 --> 0:49:37.960
<v Speaker 2>that we used to spend a ton of money on

0:49:38.000 --> 0:49:40.399
<v Speaker 2>TV in the US and now we have to spend

0:49:40.440 --> 0:49:43.120
<v Speaker 2>much less. Although we're having to start to spend more

0:49:43.160 --> 0:49:46.919
<v Speaker 2>because we're seeing more TV in the US. I think

0:49:46.960 --> 0:49:50.080
<v Speaker 2>the reason we don't make those investments is because we're

0:49:50.160 --> 0:49:53.480
<v Speaker 2>quite shortsighted when it comes to public health, and so

0:49:53.719 --> 0:49:56.880
<v Speaker 2>we think, I mean, Paul Farmer used to rail against this.

0:49:56.960 --> 0:50:00.080
<v Speaker 2>He used to talk about the everybody talks about the

0:50:00.120 --> 0:50:02.560
<v Speaker 2>cost of treating TB, and nobody talks about the cost

0:50:02.560 --> 0:50:05.240
<v Speaker 2>of not treating TV, and the cost of not treating

0:50:05.239 --> 0:50:08.720
<v Speaker 2>TV is so high, but we're accustomed to paying that cost.

0:50:08.840 --> 0:50:12.200
<v Speaker 2>We've been paying that cost in an ongoing way for generations.

0:50:12.840 --> 0:50:15.000
<v Speaker 2>It's time to start paying the cost to treat TB

0:50:15.320 --> 0:50:17.600
<v Speaker 2>and find out the benefits of not having to pay

0:50:17.600 --> 0:50:18.879
<v Speaker 2>the cost of not treating TB.

0:50:19.600 --> 0:50:22.800
<v Speaker 1>Not to mention that so many of the structural improvements

0:50:23.320 --> 0:50:27.360
<v Speaker 1>that would help to reduce the burden of tuberculosis would

0:50:27.560 --> 0:50:31.080
<v Speaker 1>make a major impact in so many other aspects of

0:50:31.120 --> 0:50:35.440
<v Speaker 1>infectious disease. It's that totally, especially when there's interactions between

0:50:35.640 --> 0:50:39.239
<v Speaker 1>tuberculosis and your immune system, and if you're infected with

0:50:39.280 --> 0:50:42.440
<v Speaker 1>this disease and tuberculosis, then that maybe that makes active

0:50:42.440 --> 0:50:47.440
<v Speaker 1>tuberculosis more likely. It's it all is interconnected, and we

0:50:47.480 --> 0:50:50.360
<v Speaker 1>are able to make large scale changes that would impact

0:50:50.400 --> 0:50:52.880
<v Speaker 1>tuberculosis and many many other things.

0:50:53.719 --> 0:50:55.960
<v Speaker 2>Yeah, and I think you're right that when we invest

0:50:56.040 --> 0:50:58.920
<v Speaker 2>in a disease like tuberculosis, we also invest in a

0:50:58.960 --> 0:51:01.959
<v Speaker 2>stronger healthcare system. When we're doing active case finding for TB,

0:51:02.520 --> 0:51:06.680
<v Speaker 2>we're also checking people's blood pressure. We're also checking for diabetes,

0:51:06.760 --> 0:51:11.080
<v Speaker 2>we're also checking, you know, for other noncommunicable diseases. And

0:51:11.120 --> 0:51:14.000
<v Speaker 2>that's a really important thing to understand that stronger healthcare

0:51:14.040 --> 0:51:18.480
<v Speaker 2>systems overall, they get stronger healthcare systems overall, and investment

0:51:18.520 --> 0:51:21.840
<v Speaker 2>in healthcare that really strengthens the system is not just

0:51:21.840 --> 0:51:24.600
<v Speaker 2>good for tuberculosis. It's also good for malaria. It's also

0:51:24.640 --> 0:51:27.600
<v Speaker 2>good for HIV. It's also good for diabetes and any

0:51:27.640 --> 0:51:28.879
<v Speaker 2>other disease that people get.

0:51:29.200 --> 0:51:33.440
<v Speaker 1>Yeah, it's it's all, it's all. It's like they're all connected.

0:51:33.040 --> 0:51:35.160
<v Speaker 2>You know, it's almost like they're all connected.

0:51:35.200 --> 0:51:40.120
<v Speaker 1>How about that. Yeah, So I want to wrap up

0:51:40.560 --> 0:51:44.200
<v Speaker 1>on a hopeful note and with two with two final

0:51:44.280 --> 0:51:47.839
<v Speaker 1>questions for you. The first is Henry. What is what

0:51:47.920 --> 0:51:49.400
<v Speaker 1>is Henry up to these days?

0:51:50.160 --> 0:51:52.600
<v Speaker 2>So? Henry was sick for a really long time and

0:51:52.640 --> 0:51:54.880
<v Speaker 2>it took a long time to cure Henry. But thanks

0:51:54.920 --> 0:51:57.560
<v Speaker 2>to the Sierra Leonian Ministry of Health and the organization

0:51:57.640 --> 0:52:01.520
<v Speaker 2>Partners in Health, the medicine that Henry needed was finally

0:52:01.560 --> 0:52:05.280
<v Speaker 2>made available to him and he survived TB. He was cured.

0:52:05.680 --> 0:52:10.240
<v Speaker 2>He is a healthy, happy young man now. He's twenty

0:52:10.239 --> 0:52:13.000
<v Speaker 2>four years old and he's a student at the University

0:52:13.000 --> 0:52:16.759
<v Speaker 2>of Sierra Leone. He's studying business and human resources. I'm

0:52:16.800 --> 0:52:20.920
<v Speaker 2>immensely proud of him. We're very close and he's just

0:52:21.000 --> 0:52:21.640
<v Speaker 2>doing awesome.

0:52:22.719 --> 0:52:26.640
<v Speaker 1>It's amazing. And he has a TikTok channel. Is that right? Oh?

0:52:26.719 --> 0:52:28.920
<v Speaker 2>Yeah, he definitely has a TikTok And he also has

0:52:28.960 --> 0:52:31.160
<v Speaker 2>a YouTube channel and he wants you to subscribe, So

0:52:31.280 --> 0:52:33.759
<v Speaker 2>google Henry Writer YouTube.

0:52:34.040 --> 0:52:34.320
<v Speaker 1>Good.

0:52:34.400 --> 0:52:34.680
<v Speaker 2>Good.

0:52:36.000 --> 0:52:39.880
<v Speaker 1>So we have this roadmap for how to make things

0:52:39.880 --> 0:52:43.080
<v Speaker 1>better with tuberculosis. We know what we can do, we

0:52:43.120 --> 0:52:46.240
<v Speaker 1>have people working on it. What are you most hopeful

0:52:46.280 --> 0:52:50.480
<v Speaker 1>for in the next in the near future, in the

0:52:50.520 --> 0:52:54.200
<v Speaker 1>maybe distant future, what do you most hope to see happen.

0:52:55.680 --> 0:52:59.000
<v Speaker 2>Well, we have a really good roadmap for how to

0:52:59.040 --> 0:53:03.400
<v Speaker 2>eliminate TB globally as a public health threat. And it

0:53:03.440 --> 0:53:05.680
<v Speaker 2>goes by an acronym. Like everything in the world of

0:53:05.680 --> 0:53:08.520
<v Speaker 2>global health, like everything in the world of tuberculosis, the

0:53:08.560 --> 0:53:13.840
<v Speaker 2>acronym is STP Search Treat Prevent So first, large scale

0:53:13.880 --> 0:53:15.840
<v Speaker 2>active case finding like we did in the US in

0:53:15.880 --> 0:53:18.880
<v Speaker 2>the nineteen forties and fifties, where we had mobile vans

0:53:18.920 --> 0:53:21.560
<v Speaker 2>with chest X rays inside of them fan out across

0:53:21.600 --> 0:53:24.960
<v Speaker 2>the country, offer people free chest X rays and then

0:53:25.000 --> 0:53:27.720
<v Speaker 2>find cases that way, so you're not only finding cases

0:53:27.760 --> 0:53:29.880
<v Speaker 2>when people are so sick that they come into the hospital.

0:53:29.880 --> 0:53:33.399
<v Speaker 2>You're identifying the disease earlier, when it's easier to treat

0:53:33.440 --> 0:53:36.360
<v Speaker 2>and there's less risk of long term disability. And then

0:53:36.400 --> 0:53:40.200
<v Speaker 2>there's the second letter T for treat. Treat every single

0:53:40.200 --> 0:53:45.400
<v Speaker 2>person with tuberculosis, offer them the kind of care that

0:53:45.440 --> 0:53:48.040
<v Speaker 2>they need in order to get well. And then the

0:53:48.120 --> 0:53:51.840
<v Speaker 2>last letter P stands for prevent preventative therapy. So we

0:53:51.960 --> 0:53:56.560
<v Speaker 2>have a way of making sure that somebody who's exposed

0:53:56.560 --> 0:54:00.600
<v Speaker 2>to TB never gets sick. It's one month of preventative antibiotics.

0:54:01.040 --> 0:54:03.319
<v Speaker 2>And so if we offer preventative therapy to all the

0:54:03.360 --> 0:54:06.400
<v Speaker 2>close contacts of the people we identify with TB, we

0:54:06.480 --> 0:54:09.960
<v Speaker 2>can end that chain of transmission completely. This is a bold,

0:54:10.000 --> 0:54:12.560
<v Speaker 2>ambitious plan. You know. Some of the estimates say that

0:54:12.560 --> 0:54:14.560
<v Speaker 2>it would cost twenty five billion dollars a year, but

0:54:14.600 --> 0:54:17.360
<v Speaker 2>as you pointed out, each of those dollars would result

0:54:17.360 --> 0:54:22.200
<v Speaker 2>in forty dollars of future benefit to our species, and

0:54:22.280 --> 0:54:26.560
<v Speaker 2>more importantly, it would result in six point six by

0:54:26.560 --> 0:54:29.800
<v Speaker 2>some estimates, million fewer deaths over the next seven years.

0:54:30.320 --> 0:54:33.040
<v Speaker 2>And there is hardly a better bet in global health

0:54:33.040 --> 0:54:33.359
<v Speaker 2>than that.

0:54:34.200 --> 0:54:39.680
<v Speaker 1>Yeah, I completely agree, John. It has been so fantastic

0:54:39.760 --> 0:54:42.279
<v Speaker 1>to chat with you and an honor to meet you,

0:54:42.520 --> 0:54:45.480
<v Speaker 1>truly thrilling. Thank you so much for a great conversation.

0:54:45.840 --> 0:54:47.840
<v Speaker 2>Thank you so much. Erin. It's so cool to be

0:54:47.880 --> 0:54:49.839
<v Speaker 2>able to meet you and to be on the pod.

0:54:49.880 --> 0:54:50.879
<v Speaker 2>I really appreciate it.

0:55:09.680 --> 0:55:12.680
<v Speaker 1>A huge thanks again to John Green for taking the

0:55:12.680 --> 0:55:15.799
<v Speaker 1>time to chat with me. That was such a great conversation.

0:55:16.680 --> 0:55:20.080
<v Speaker 1>For more tuberculosis talk, check out our website this podcast

0:55:20.120 --> 0:55:22.080
<v Speaker 1>will kill You dot com. We're all post a link

0:55:22.080 --> 0:55:25.640
<v Speaker 1>to where you can find Everything is Tuberculosis, as well

0:55:25.680 --> 0:55:28.440
<v Speaker 1>as a link to John's site, and don't forget you

0:55:28.480 --> 0:55:30.919
<v Speaker 1>can check out our website for all sorts of other

0:55:31.000 --> 0:55:35.120
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0:55:42.000 --> 0:55:46.319
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0:55:46.800 --> 0:55:49.360
<v Speaker 1>Speaking of which, thank you to Bloodmobile for preventing the

0:55:49.440 --> 0:55:52.960
<v Speaker 1>music for this episode and all of our episodes. Thank

0:55:53.000 --> 0:55:56.480
<v Speaker 1>you to Leana Squilacci and Tom Bryfogel for our excellent

0:55:56.520 --> 0:56:00.920
<v Speaker 1>audio mixing. And thank you to you listeners. Listen, I

0:56:00.960 --> 0:56:04.040
<v Speaker 1>hope you liked this episode and our loving being part

0:56:04.120 --> 0:56:08.359
<v Speaker 1>of the TPWKY book Club. A special thank you, as

0:56:08.520 --> 0:56:13.080
<v Speaker 1>always to our fantastic patrons. We appreciate your support so

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<v Speaker 1>very much. Well, until next time, keep washing those hands.