WEBVTT - Listener Questions #17

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<v Speaker 1>Screwworms have invaded beyond the Panama Canal. Will they infect

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<v Speaker 1>Texas cows grazing amongst the chaparral?

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<v Speaker 2>How would life evolve without a moon? Would we have people?

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<v Speaker 2>Cats and funky mushrooms?

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<v Speaker 1>How long is the wait until synthetic blood goes on sale?

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<v Speaker 1>I promise I'm not a vampire. I'm just a little pale.

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<v Speaker 2>Whatever question keeps you up at night, Daniel and Kelly's

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<v Speaker 2>answer will make it all right.

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<v Speaker 1>Welcome to another Listener Questions episode on Daniel and Kelly's

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<v Speaker 1>Extraordinary Universe.

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<v Speaker 2>Hi. I'm Daniel. I'm a particle physicist and I'm not

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<v Speaker 2>a vegetarian, but I don't like to eat blood.

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<v Speaker 3>Hello, I'm Kelly Waiter Smith.

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<v Speaker 1>I study Paris and space and I also am not

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<v Speaker 1>a big fan of eating blood. What are those blood

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<v Speaker 1>sausages or whatever that are popular in the UK? Yeah,

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<v Speaker 1>I can't do that, or at least I've never tried.

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<v Speaker 1>Maybe I'd like it, but I can't get myself to

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<v Speaker 1>try it.

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<v Speaker 2>There's some line for me between like normal muscle and

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<v Speaker 2>like the rest of the body and the blood and

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<v Speaker 2>the brain and the guts and stuff. It just creeps me.

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<v Speaker 2>Out though. Katrina has a friend who's big into cooking organs,

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<v Speaker 2>and she has a website. I think it's called Awful

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<v Speaker 2>Recipes o ffal.

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<v Speaker 1>You know, I feel like it's actually a deficit of

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<v Speaker 1>my character that I'm not into eating more of the animal,

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<v Speaker 1>because I do feel like, yeah, that if you're going

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<v Speaker 1>to take another animal's life, you really should make the

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<v Speaker 1>most of it.

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<v Speaker 3>But I just really have problems with the texture and stuff.

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<v Speaker 1>So my solution has been to try to cut down

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<v Speaker 1>on meat as much as I can.

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<v Speaker 2>No, I totally agree it feels weird to just throw

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<v Speaker 2>away parts of an animal because you're like, oh, ichy,

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<v Speaker 2>and when really the whole thing is kind of ikey

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<v Speaker 2>if you think about it too much, which we all should.

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<v Speaker 2>We all all should be thinking about it too much

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<v Speaker 2>and feeling okay about our choices.

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<v Speaker 3>That's right, Yes, we should think through our choices.

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<v Speaker 1>It's so easy to be separated from the food that

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<v Speaker 1>you eat and not think through the implications of what's

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<v Speaker 1>happening there.

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<v Speaker 2>But nobody's gonna have an appetite after this episode anyway, right, Kelly,

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<v Speaker 2>I'm here to help.

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<v Speaker 1>All right, So let's jump right into question number one

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<v Speaker 1>from John, this is a topic I've been wanted an

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<v Speaker 1>excuse to dig into for a while, and so let's

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<v Speaker 1>hear what disgusting thing John wanted to know about. Well, friends,

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<v Speaker 1>At this point in the episode, we thought we were

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<v Speaker 1>going to drop an audio file where our friend John

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<v Speaker 1>reads his questions. But sometimes an audience member will send

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<v Speaker 1>a question and then they disappear. Maybe they've moved away,

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<v Speaker 1>maybe they're busy, hopefully they're well. We never got the

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<v Speaker 1>audio file, so I'm going to go ahead and read

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<v Speaker 1>the question from John. Here we go, Please do a

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<v Speaker 1>segment on the current situation at the South border concern

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<v Speaker 1>cattle and the re emergence of the parasitic fly and

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<v Speaker 1>their maggot offspring known as screwworms. Is the current embargo

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<v Speaker 1>something worth worrying about? Will it spread across the border regardless.

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<v Speaker 3>Of what we do?

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<v Speaker 1>Are there any human diseases related to the parasite after

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<v Speaker 1>eliminating them back fifty sixty years ago? How did it

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<v Speaker 1>become a problem again? Catching us by surprise?

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<v Speaker 3>Thanks? Oh man, Daniel, all right, nobody.

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<v Speaker 2>Why were you so excited to get this question?

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<v Speaker 3>Kelly?

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<v Speaker 1>Well, because I had been hearing about screwworms for a while,

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<v Speaker 1>but had never really dug in, and so they were

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<v Speaker 1>on sort of like the periphery of my consciousness. And

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<v Speaker 1>I was like, oh great, now there's a new parasite

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<v Speaker 1>that I have an excuse to learn about. But I

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<v Speaker 1>what is a really good word for? Like I'm begging,

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<v Speaker 1>I beseech you. I beseech you do not look up

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<v Speaker 1>pictures of screwworm or like what screwworm does to people,

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<v Speaker 1>because the photos have to Oh god, it's really horrible.

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<v Speaker 1>And if you do, we will go ahead and record

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<v Speaker 1>some video so that we can put your reaction up

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<v Speaker 1>on Blue Sky and our Instagram accounts because it's really horrifying.

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<v Speaker 1>So so let me go into the life cycle before

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<v Speaker 1>we do anything else.

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<v Speaker 2>Okay, tell us what is this thing? Basically, because I

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<v Speaker 2>know just because it's called a screw worm doesn't mean

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<v Speaker 2>it's a worm.

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<v Speaker 3>It's not a worm.

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<v Speaker 2>It's called the screw worm, doesn't mean it screws anything.

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<v Speaker 2>So what is it? And how does it live?

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<v Speaker 1>It is not a worm, but it does screw, So

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<v Speaker 1>it is this we're talking about the new World screw worm.

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<v Speaker 1>There is another species in the quote unquote old world.

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<v Speaker 1>And so the deal here is it's a fly. Mom

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<v Speaker 1>lays her eggs around the edges of wounds or on

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<v Speaker 1>mucous membrane, so like around your eyes or in your

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<v Speaker 1>mouth and stuff. I know, I know, bad start bad start.

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<v Speaker 1>The eggs hatch and the larva like the baby's hatch

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<v Speaker 1>out of the eggs, and then they start screwing into

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<v Speaker 1>the flesh to get into the flesh to eat it.

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<v Speaker 1>And that's why they're called screw worms. I guess they

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<v Speaker 1>sort of screw in the way a screw screws into wood.

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<v Speaker 2>Why did they screw? I mean, they can't just like

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<v Speaker 2>chew their way in like any normal parasite.

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<v Speaker 3>I mean, I guess they're doing both.

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<v Speaker 1>But also a lot of parasites aren't like chewing their

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<v Speaker 1>way through flesh. So for example, you know, hookworms have

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<v Speaker 1>like hooked mouths and they sort of bite down, but

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<v Speaker 1>they're not like kind of chewing their way through and

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<v Speaker 1>migrating through the flesh, whereas screw worms are migrating through

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<v Speaker 1>the flesh, which is really truly horrible.

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<v Speaker 2>Why are they migrating through? Like where did they want

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<v Speaker 2>to go? I happen to be between them and their destination.

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<v Speaker 1>Well, no, they've consumed the flesh, they're done with it.

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<v Speaker 1>They want more flesh, and so they're screwing in to

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<v Speaker 1>get more of it. And so, you know, we talked

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<v Speaker 1>in a previous episode about maggots that specifically ate dead tissue,

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<v Speaker 1>and so they were useful for cleaning out wounds. But

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<v Speaker 1>these flies are specifically eating the live tissue. Wow, and

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<v Speaker 1>they are not pleasant. So they screw in, they eat.

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<v Speaker 1>When they're done eating, they fall out and off the

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<v Speaker 1>host onto the ground.

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<v Speaker 4>All right.

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<v Speaker 3>They do a stage called pew.

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<v Speaker 1>Painting, and then when they hatch, they emerge as adults

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<v Speaker 1>who go off in search of more flesh to lay

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<v Speaker 1>their eggs on.

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<v Speaker 2>How come nobody call these like zombie flies or something?

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<v Speaker 3>So we usually reserve the word zombie.

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<v Speaker 1>For instances where a host behavior is being sort of

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<v Speaker 1>like manipulated in a way that benefits the parasite at

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<v Speaker 1>the expense of the host.

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<v Speaker 2>I love this. They're like semi official rules in biology

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<v Speaker 2>for what you can call a zombie.

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<v Speaker 3>Oh no, no, there's a lot of fighting over this.

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<v Speaker 1>There are people who feel like you shouldn't be using

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<v Speaker 1>the phrase zombie at all because you're just going to

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<v Speaker 1>confuse the public. They're not coming back from the dead.

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<v Speaker 1>I feel like the public gets that, like you need

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<v Speaker 1>to give them a little bit more credit.

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<v Speaker 2>But are there similar rules for like werewolf or mummy.

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<v Speaker 3>I don't think so.

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<v Speaker 2>No, no, all right, so it's a free for folks.

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<v Speaker 2>If you discover something, feel free to call it a

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<v Speaker 2>where way.

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<v Speaker 1>Oh no, no, there are there are a fit mum,

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<v Speaker 1>and so they essentially shells of their former self because

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<v Speaker 1>parasites have like eaten their insides and stuff, and they're

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<v Speaker 1>like pale relative to the others. I don't know too

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<v Speaker 1>much about aphan mummies anyway, So to get back on track,

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<v Speaker 1>I ended up watching a video lecture that veterinarians are

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<v Speaker 1>supposed to watch to get like, you know, credit for

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<v Speaker 1>their requirements for their field about screwworms, and they were like,

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<v Speaker 1>sometimes it'll just be like a pinprick hole in an animal,

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<v Speaker 1>because like you know, dogs and stuff can get this too,

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<v Speaker 1>and you just have to feel the hole and you

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<v Speaker 1>feel the worms moving around inside. So it's not even

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<v Speaker 1>that it's like a big anyway, super gross.

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<v Speaker 2>So you can be walking around with like a sack

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<v Speaker 2>of these worms inside you.

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<v Speaker 1>You would know, But yes, the answer is yes. So

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<v Speaker 1>females lay something like two hundred to three hundred eggs

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<v Speaker 1>at a time, and they can lay two to four

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<v Speaker 1>batches in their lifetime, so you can pretty quickly once

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<v Speaker 1>you have an open wound, it attracts.

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<v Speaker 3>More screwflies or more screw worms.

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<v Speaker 1>So if you're in an area where there's a lot

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<v Speaker 1>of screwworms, you can pretty quickly build up a life

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<v Speaker 1>threatening illness because they're just eating so much of you.

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<v Speaker 1>Or you can get secondary infections because now you have

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<v Speaker 1>this growing wounds that can you know, acquire bacteria and

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<v Speaker 1>you die that way.

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<v Speaker 3>So it's truly awful.

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<v Speaker 2>And what do they usually eat? Is it mostly people

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<v Speaker 2>or is it dogs? Are they totally indiscriminate.

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<v Speaker 1>Anything they can really get their hands on, So quite

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<v Speaker 1>often they're going after livestock or they can go after wildlife.

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<v Speaker 1>Sometimes you find it in pets and occasionally you will

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<v Speaker 1>find it in people.

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<v Speaker 2>And do they have the same preference for flesh as

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<v Speaker 2>Kelly does, like do they prefer the muscle or they

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<v Speaker 2>eat you know, organs and eyeballs and any sorts of things.

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<v Speaker 1>So I don't preferentially eat wounds on animals and they

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<v Speaker 1>have a tendency also to go form mucus membranes and

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<v Speaker 1>like genitalia stuff like that, and so I would say

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<v Speaker 1>they do not have similar preferences to Kelly.

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<v Speaker 2>I'm not trying to put you together in a category.

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<v Speaker 2>It's just using you as an example.

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<v Speaker 1>I'm feeling a little insulted, but I'm gonna I really

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<v Speaker 1>like parasites enough that I'm going to rise above and

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<v Speaker 1>decide that to compliment. But so this used to be

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<v Speaker 1>in the United States. It was a huge problem. Like

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<v Speaker 1>in nineteen thirty five, one hundred and eighty thousand cattle

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<v Speaker 1>died in Texas alone from this parasite. So you typically

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<v Speaker 1>find it in South and Central America, and it was

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<v Speaker 1>in North America for a while. Tended to be in

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<v Speaker 1>the Southern States because that stage that lives off of

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<v Speaker 1>the animals is cold sensitive, so if it freezes, that

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<v Speaker 1>kills them, but they can come back during the summer,

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<v Speaker 1>so you can still get them pretty far north, just

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<v Speaker 1>depending on where they've managed to travel. But this was

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<v Speaker 1>such a big problem for agriculture that the United States said,

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<v Speaker 1>all right, we absolutely need to do something about this.

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<v Speaker 1>And so what they did was they developed in nineteen

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<v Speaker 1>fifty eight, what's still called the sterile insect technique.

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<v Speaker 3>And this is something I think you might enjoy.

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<v Speaker 1>So essentially, they they get the flies, they can well

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<v Speaker 1>wait for it, wait for it.

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<v Speaker 2>I love hearing about sterility as a rule.

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<v Speaker 3>So yeah, oh yeah, well I know that's a thing

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<v Speaker 3>for you. I don't know you started this path. I

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<v Speaker 3>just took the next step.

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<v Speaker 2>Well, what is a sterile insect technique?

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<v Speaker 1>Okay, So they take a stage of the flies and

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<v Speaker 1>they expose them to radiation, and in particular, they're exposing

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<v Speaker 1>them to low doses of cobalt and this essentially sterilizes

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<v Speaker 1>the male flies and then they release loads of male

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<v Speaker 1>flies out there. And the thing that you need to

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<v Speaker 1>know about screwworms is that the females only mate once

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<v Speaker 1>in their life, even though they're laying multiple clutches of eggs.

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<v Speaker 1>So if a female mates with one of these irradiated males,

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<v Speaker 1>the eggs that she lays will not hatch. And so

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<v Speaker 1>by doing this, you essentially are like pulling females out

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<v Speaker 1>of the population, like they still exist, but they're not

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<v Speaker 1>making any viable eggs. And so every generation you put

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<v Speaker 1>more sterile males out there, and over time you can

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<v Speaker 1>drop the population down to zero using.

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<v Speaker 2>This method, down to zero, really.

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<v Speaker 3>Down to zero.

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<v Speaker 1>So actually we started doing this in nineteen fifty eight,

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<v Speaker 1>and by nineteen sixty six the United States was free

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<v Speaker 1>of New World screwworm?

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<v Speaker 2>How do you get down to zero? I understand that

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<v Speaker 2>you can suppress the population because you have some males

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<v Speaker 2>that are sterile, But as long as you have any

0:11:18.160 --> 0:11:20.360
<v Speaker 2>males that are not sterile, won't you keep getting some

0:11:20.400 --> 0:11:21.240
<v Speaker 2>more screw worms.

0:11:21.520 --> 0:11:24.440
<v Speaker 1>They do this generation after generation after generation, and they

0:11:24.480 --> 0:11:27.360
<v Speaker 1>swamp the population with these sterile males. And so they're

0:11:27.360 --> 0:11:31.640
<v Speaker 1>literally like loading up airplanes and dropping airplanes full of

0:11:32.000 --> 0:11:34.480
<v Speaker 1>no no, no, no, This is how they distribute the

0:11:34.520 --> 0:11:38.040
<v Speaker 1>screw worms. They drop airplanes full of these sterile insects.

0:11:38.240 --> 0:11:41.680
<v Speaker 2>If anything is going to inspire conspiracy theories about the government,

0:11:41.960 --> 0:11:46.200
<v Speaker 2>then like dropping airplane loads of intentionally irradiated flies on

0:11:46.280 --> 0:11:46.959
<v Speaker 2>the population.

0:11:47.240 --> 0:11:48.760
<v Speaker 3>Wow, flesh eating flies.

0:11:48.840 --> 0:11:52.520
<v Speaker 2>Yeah, that's right, eating irradiated flies. Oh my gosh. All right,

0:11:52.800 --> 0:11:55.680
<v Speaker 2>but it's good for you, folks, really, it's in your interest.

0:11:55.840 --> 0:11:57.559
<v Speaker 3>Trust us, trust the scientists.

0:11:57.880 --> 0:12:04.120
<v Speaker 2>So all right, so they did this and it worked amazingly.

0:12:04.360 --> 0:12:05.719
<v Speaker 2>Ya science M M.

0:12:06.400 --> 0:12:10.000
<v Speaker 1>But the problem was that screwworm was still present in Mexico,

0:12:10.600 --> 0:12:13.400
<v Speaker 1>and so it kept getting across the southern border, and

0:12:13.440 --> 0:12:15.880
<v Speaker 1>so this problem didn't go away. So we decided, okay,

0:12:15.880 --> 0:12:18.520
<v Speaker 1>you know what, We're going to eradicate screw worm from

0:12:18.520 --> 0:12:21.520
<v Speaker 1>Mexico as well. Yeah, and so they started, with the

0:12:21.559 --> 0:12:25.200
<v Speaker 1>Mexican government's permission. This was a collaboration. They started dropping

0:12:25.280 --> 0:12:29.320
<v Speaker 1>plane folds of sterile screw worms over Mexico and by

0:12:29.400 --> 0:12:33.440
<v Speaker 1>nineteen ninety one, Mexico was free of screwworm. Yay, which

0:12:33.440 --> 0:12:36.520
<v Speaker 1>is amazing. And so they ended up marching screw worm

0:12:36.679 --> 0:12:40.960
<v Speaker 1>back farther and farther and farther until screwworm was only

0:12:41.000 --> 0:12:44.120
<v Speaker 1>found on the southern side of the Panama Canal.

0:12:44.240 --> 0:12:46.320
<v Speaker 2>This seems like such good news. It must be ironic

0:12:46.440 --> 0:12:49.360
<v Speaker 2>foreshadowing for some terrible twist you're about to drop on us.

0:12:50.240 --> 0:12:52.600
<v Speaker 3>I mean, this is no this is good news, full stop.

0:12:52.679 --> 0:12:52.920
<v Speaker 2>Okay.

0:12:52.960 --> 0:12:56.160
<v Speaker 1>There were like decades where we were completely without screw worms.

0:12:56.280 --> 0:12:59.680
<v Speaker 1>It's amazing, like go science. And so Panama has this

0:12:59.679 --> 0:13:03.599
<v Speaker 1>facil where they're constantly making these sterile insect males and

0:13:03.640 --> 0:13:07.320
<v Speaker 1>they're constantly dropping them in the Panama Canal region to

0:13:07.320 --> 0:13:09.319
<v Speaker 1>try to make sure that screw worm doesn't make its

0:13:09.360 --> 0:13:11.400
<v Speaker 1>way back up again, because it's still present south of

0:13:11.400 --> 0:13:12.160
<v Speaker 1>the Panama Canal.

0:13:12.240 --> 0:13:14.360
<v Speaker 2>Why don't the South American governments do this as well

0:13:14.400 --> 0:13:15.600
<v Speaker 2>so we can eradicate this guy.

0:13:15.760 --> 0:13:17.360
<v Speaker 3>Yeah, that's a great question. I don't know.

0:13:17.520 --> 0:13:20.960
<v Speaker 1>I don't know if it's too expensive or what. But

0:13:21.720 --> 0:13:24.960
<v Speaker 1>the countries that did eradicate it had American help and

0:13:25.000 --> 0:13:27.640
<v Speaker 1>collaboration to sort of scale up to keep this going.

0:13:28.720 --> 0:13:31.160
<v Speaker 1>But it's kind of amazing that it hasn't gotten past

0:13:31.280 --> 0:13:34.360
<v Speaker 1>because we move a lot of animals around, you know,

0:13:34.559 --> 0:13:37.280
<v Speaker 1>and so like in two thousand, a gelding, which is

0:13:37.280 --> 0:13:38.640
<v Speaker 1>like a kind of horse but I don't know much

0:13:38.640 --> 0:13:41.800
<v Speaker 1>about horses because I hate horses, was imported.

0:13:41.960 --> 0:13:44.600
<v Speaker 2>Well, technically, it's a sterilized male horse.

0:13:44.720 --> 0:13:45.319
<v Speaker 3>Okay, thank you.

0:13:45.360 --> 0:13:47.120
<v Speaker 2>Sterilized surgically oh ye, not.

0:13:47.120 --> 0:13:51.240
<v Speaker 1>With radiation, not with cobalt. Oh no, snip snip okay,

0:13:51.280 --> 0:13:51.559
<v Speaker 1>got it.

0:13:51.600 --> 0:13:51.880
<v Speaker 3>Got it.

0:13:51.920 --> 0:13:55.080
<v Speaker 1>So a snip snipped mail horse was brought to Florida

0:13:55.120 --> 0:13:58.400
<v Speaker 1>from South America, and as it was coming across the border,

0:13:58.400 --> 0:14:00.800
<v Speaker 1>it was discovered that it had screw and it went

0:14:00.800 --> 0:14:04.760
<v Speaker 1>into quarantine, got treated, and so it didn't spread yay.

0:14:05.320 --> 0:14:07.640
<v Speaker 1>In two thousand and seven, a dog from Trinidad was

0:14:07.679 --> 0:14:10.760
<v Speaker 1>sent to Florida and it had screwworm larva you know,

0:14:10.880 --> 0:14:12.280
<v Speaker 1>snacking behind its eyes.

0:14:12.520 --> 0:14:14.560
<v Speaker 3>Oh god, I know, I know.

0:14:14.720 --> 0:14:17.360
<v Speaker 1>And the dog made it to Mississippi and so it

0:14:17.400 --> 0:14:20.880
<v Speaker 1>could have been spreading it, but a veterinarian in Mississippi

0:14:20.920 --> 0:14:24.400
<v Speaker 1>found them, reported it. It was controlled, it got treated,

0:14:24.440 --> 0:14:26.160
<v Speaker 1>the dog lived, It didn't spread.

0:14:26.080 --> 0:14:28.120
<v Speaker 2>Amazing, but it feels like fingers in the dike.

0:14:28.400 --> 0:14:30.880
<v Speaker 1>Yes, yeah, it does, right. So in twenty sixteen, there

0:14:30.920 --> 0:14:33.240
<v Speaker 1>was an outbreak in the Florida Keys. We don't know

0:14:33.320 --> 0:14:36.000
<v Speaker 1>how screw worm made it to the Florida Keys, but

0:14:36.120 --> 0:14:38.160
<v Speaker 1>it got there and it ended up in the key

0:14:38.200 --> 0:14:41.600
<v Speaker 1>deer population, which is an endangered subspecies of white tailed

0:14:41.600 --> 0:14:44.440
<v Speaker 1>deer that you find in that area, and one hundred

0:14:44.480 --> 0:14:46.440
<v Speaker 1>and thirty five of them died. That was about ten

0:14:46.440 --> 0:14:51.280
<v Speaker 1>percent of the population. It also infected dogs, pet pigs, cats,

0:14:51.320 --> 0:14:52.040
<v Speaker 1>in a raccoon.

0:14:52.520 --> 0:14:53.800
<v Speaker 3>I know, super sad.

0:14:54.200 --> 0:14:57.320
<v Speaker 1>But we put sterile males out and we were able

0:14:57.360 --> 0:15:00.480
<v Speaker 1>to get it under control again. So using that steril

0:15:00.520 --> 0:15:04.360
<v Speaker 1>insect technique, we wiped it back out again. But this

0:15:04.560 --> 0:15:07.880
<v Speaker 1>current outbreak, as I understand. It is the most concerning

0:15:07.880 --> 0:15:11.480
<v Speaker 1>outbreak that's happened so far. So screwworm has managed to

0:15:11.600 --> 0:15:14.200
<v Speaker 1>jump above the Panama Canal. I don't think we know

0:15:14.280 --> 0:15:16.960
<v Speaker 1>how it happened, and it has been sort of creeping

0:15:17.000 --> 0:15:21.080
<v Speaker 1>its way back up, heading into Mexico and getting close

0:15:21.160 --> 0:15:24.480
<v Speaker 1>to the border. So Zach was just in Texas visiting

0:15:24.520 --> 0:15:26.440
<v Speaker 1>his family and he said that they they were like

0:15:26.480 --> 0:15:30.840
<v Speaker 1>commercials about you know, watch out for screwworm. Check your animals,

0:15:30.960 --> 0:15:32.560
<v Speaker 1>keep an eye out, because we really want to make

0:15:32.560 --> 0:15:34.160
<v Speaker 1>sure this thing doesn't establish here.

0:15:34.520 --> 0:15:36.200
<v Speaker 2>Check your eyeballs, Check your eyeballs.

0:15:36.240 --> 0:15:36.920
<v Speaker 3>Oh gross.

0:15:37.080 --> 0:15:39.320
<v Speaker 1>So it's been estimated that if it takes hold in

0:15:39.320 --> 0:15:42.040
<v Speaker 1>the US, it could cost over one and a quarter

0:15:42.160 --> 0:15:44.840
<v Speaker 1>billion dollars to eradicate it from the US if we

0:15:44.880 --> 0:15:47.600
<v Speaker 1>had to deal with this again. It was recently announced

0:15:47.640 --> 0:15:49.520
<v Speaker 1>that eight and a half million dollars is going to

0:15:49.560 --> 0:15:53.680
<v Speaker 1>go to building another facility to raise sterile mail insects

0:15:54.120 --> 0:15:56.240
<v Speaker 1>in Texas and then they're going to work with the

0:15:56.240 --> 0:15:59.320
<v Speaker 1>Panama facility to try to wipe screw worm out between

0:15:59.600 --> 0:16:02.280
<v Speaker 1>Panama and the US and the areas where it's taken hold.

0:16:02.840 --> 0:16:05.880
<v Speaker 1>So they are putting a lot of energy and money

0:16:05.880 --> 0:16:08.440
<v Speaker 1>into trying to tackle this because it would be a

0:16:08.440 --> 0:16:10.000
<v Speaker 1>big deal if it got across the border.

0:16:10.120 --> 0:16:12.160
<v Speaker 2>I really hope they tackle it before it gets to

0:16:12.280 --> 0:16:12.680
<v Speaker 2>my house.

0:16:12.960 --> 0:16:15.480
<v Speaker 1>Yes, absolutely, Well, you know, they probably don't want to

0:16:15.480 --> 0:16:17.640
<v Speaker 1>go to California anyway, because it's like kind of a

0:16:17.640 --> 0:16:18.320
<v Speaker 1>boring place.

0:16:18.600 --> 0:16:20.400
<v Speaker 3>I'm more worried about Virginia.

0:16:20.520 --> 0:16:23.520
<v Speaker 2>But they don't like mountains, they don't like oceans, they

0:16:23.520 --> 0:16:26.680
<v Speaker 2>don't like beautiful weather. You're right, they should head to Virginia.

0:16:26.840 --> 0:16:30.160
<v Speaker 1>Oh yeah, We've got much better wildlife here, and I'm

0:16:30.200 --> 0:16:33.680
<v Speaker 1>sure the wildlife is delicious, and so, you know, come

0:16:33.760 --> 0:16:34.320
<v Speaker 1>to Virginia.

0:16:34.400 --> 0:16:35.080
<v Speaker 3>This got weird.

0:16:35.480 --> 0:16:41.560
<v Speaker 1>So well, Virginia will change our motto from a Virginia

0:16:41.640 --> 0:16:45.840
<v Speaker 1>is for lovers to Virginia is for screw worms. But anyway,

0:16:46.400 --> 0:16:50.119
<v Speaker 1>so John wanted to know, should we worry about this problem?

0:16:50.400 --> 0:16:51.920
<v Speaker 2>I'm already worrying. Yes.

0:16:52.160 --> 0:16:54.480
<v Speaker 1>Yeah, the answer is yes we should worry, and people

0:16:54.520 --> 0:16:57.400
<v Speaker 1>are worrying and taking what seems to be appropriate measures

0:16:57.400 --> 0:17:00.720
<v Speaker 1>to me, And are there any human disease is related

0:17:00.720 --> 0:17:03.720
<v Speaker 1>to this parasite? I wasn't able to find any. So

0:17:03.760 --> 0:17:07.240
<v Speaker 1>the parasite can infect and live in people, and that's horrible.

0:17:07.600 --> 0:17:10.080
<v Speaker 1>But I don't think it spreads any diseases as far

0:17:10.080 --> 0:17:12.879
<v Speaker 1>as I was able to tell. And how did it

0:17:12.920 --> 0:17:15.720
<v Speaker 1>manage to catch us by surprise? I would say it

0:17:15.720 --> 0:17:19.040
<v Speaker 1>didn't catch us by surprise. Monitoring for this is pretty widespread,

0:17:19.520 --> 0:17:22.280
<v Speaker 1>and we've been constantly sort of working to keep this

0:17:22.320 --> 0:17:23.560
<v Speaker 1>below the southern border.

0:17:24.480 --> 0:17:27.400
<v Speaker 3>To be honest, I am amazed and.

0:17:27.520 --> 0:17:31.200
<v Speaker 1>Very proud of our efforts that it hasn't gotten above

0:17:31.240 --> 0:17:34.080
<v Speaker 1>Panama more often like this. It's incredible that we've been

0:17:34.080 --> 0:17:36.800
<v Speaker 1>able to control it to the extent that we have. So,

0:17:37.440 --> 0:17:39.720
<v Speaker 1>you know, something just managed to move across the border

0:17:39.720 --> 0:17:41.960
<v Speaker 1>that was infected by screwworm and we're on it again.

0:17:42.000 --> 0:17:44.960
<v Speaker 1>This is probably unless we completely remove screwworm from the

0:17:44.960 --> 0:17:47.280
<v Speaker 1>face of the planet, this is something we're just always

0:17:47.280 --> 0:17:49.560
<v Speaker 1>going to have to deal with happening from time to time,

0:17:49.840 --> 0:17:50.639
<v Speaker 1>would be my guess.

0:17:50.960 --> 0:17:52.760
<v Speaker 2>Well, let me take the other side of this. Let

0:17:52.840 --> 0:17:56.560
<v Speaker 2>me be the screw worm advocate. You know, many things

0:17:56.680 --> 0:17:59.400
<v Speaker 2>are unpleasant or heat or gross, but then it turns

0:17:59.440 --> 0:18:03.240
<v Speaker 2>out they serve some positive function in the ecosystem. If

0:18:03.240 --> 0:18:05.920
<v Speaker 2>we remove screwworm from the Earth, we just like delete

0:18:06.000 --> 0:18:09.240
<v Speaker 2>all of them. Is there some beautiful critter that like

0:18:09.320 --> 0:18:11.600
<v Speaker 2>eats screw worms. It's no longer going to be around.

0:18:11.800 --> 0:18:15.199
<v Speaker 1>No, no, So I don't actually know the answer, But

0:18:15.240 --> 0:18:17.840
<v Speaker 1>what I can tell you is that for decades we

0:18:17.960 --> 0:18:22.200
<v Speaker 1>have managed to eradicate screwworm from North America and most

0:18:22.200 --> 0:18:26.439
<v Speaker 1>of Central America, and we haven't seen ecosystems collapse or

0:18:26.480 --> 0:18:28.400
<v Speaker 1>something like that, you know. So it's possible that there

0:18:28.520 --> 0:18:32.719
<v Speaker 1>is that birds really liked eating screw worms and they

0:18:32.760 --> 0:18:33.440
<v Speaker 1>have a little bit.

0:18:33.359 --> 0:18:34.120
<v Speaker 3>Less food to eat.

0:18:34.440 --> 0:18:36.879
<v Speaker 1>Yeah, but I think this is one of those things

0:18:36.920 --> 0:18:41.520
<v Speaker 1>where as a pro human individual, I think that any

0:18:41.560 --> 0:18:45.639
<v Speaker 1>ecosystem costs would be worth it because otherwise that you know,

0:18:45.680 --> 0:18:48.679
<v Speaker 1>the costs for our livestock and our pets and for

0:18:49.040 --> 0:18:52.680
<v Speaker 1>you know, endangered species like the key deer, it would

0:18:52.720 --> 0:18:54.320
<v Speaker 1>be better to not have it around.

0:18:54.240 --> 0:18:56.600
<v Speaker 2>And then Kelly wouldn't have to think about gross pictures

0:18:56.640 --> 0:18:58.160
<v Speaker 2>online as she eats her hamburger.

0:18:58.359 --> 0:19:00.840
<v Speaker 1>My god, it was a horrible photo of like the

0:19:00.880 --> 0:19:03.320
<v Speaker 1>head of a key dear that I won't I'll stop,

0:19:03.440 --> 0:19:28.679
<v Speaker 1>So John, thank you for this fascinating question and go science. Okay,

0:19:29.240 --> 0:19:32.720
<v Speaker 1>next up, we have a question from Robert from Richmond.

0:19:32.960 --> 0:19:35.320
<v Speaker 2>Thank you very much, Robert for reaching out to me

0:19:35.480 --> 0:19:37.920
<v Speaker 2>to ask this question. And remember to everybody out there,

0:19:37.960 --> 0:19:40.320
<v Speaker 2>if you have a question about the way the universe works,

0:19:40.480 --> 0:19:43.280
<v Speaker 2>something you want to understand, and you'd like Daniel and

0:19:43.359 --> 0:19:45.600
<v Speaker 2>Kelly to break it down for you, please just write

0:19:45.600 --> 0:19:49.120
<v Speaker 2>to us to questions at Danielankelly dot org. Don't ask

0:19:49.200 --> 0:19:53.160
<v Speaker 2>chat GPT, don't read some nonsense online. Reach out to us.

0:19:53.160 --> 0:19:56.480
<v Speaker 2>We really will set you right, all right. Here's Robert

0:19:56.520 --> 0:19:57.320
<v Speaker 2>from Richmond.

0:19:57.680 --> 0:20:01.480
<v Speaker 5>This is Robert from Richmond, Virginia. I was wondering how

0:20:01.640 --> 0:20:05.560
<v Speaker 5>life on Earth would have evolved differently, if at all,

0:20:06.200 --> 0:20:09.359
<v Speaker 5>if we didn't have the moon, so we wouldn't have

0:20:10.040 --> 0:20:16.480
<v Speaker 5>tied to mix the primordial soup, we wouldn't necessarily have

0:20:16.600 --> 0:20:21.600
<v Speaker 5>as much of a tilted axis. Even nocturnal predators wouldn't

0:20:21.600 --> 0:20:23.679
<v Speaker 5>have the light of the moon at night to hunt.

0:20:24.240 --> 0:20:28.120
<v Speaker 5>The moon has been there for so long that it's

0:20:28.200 --> 0:20:31.000
<v Speaker 5>kind of interesting to see how it would be different

0:20:31.000 --> 0:20:34.439
<v Speaker 5>without it. But also, there are so many planets that

0:20:34.520 --> 0:20:36.600
<v Speaker 5>have more than one moon. We're kind of unique in

0:20:36.600 --> 0:20:39.720
<v Speaker 5>that way. How would life evolve differently with more moons?

0:20:40.119 --> 0:20:42.680
<v Speaker 5>I know there's a lot too unpacked there. I appreciate

0:20:42.720 --> 0:20:44.879
<v Speaker 5>all the hard work. Keep it up look forward to

0:20:44.920 --> 0:20:45.960
<v Speaker 5>hearing from you guys.

0:20:46.280 --> 0:20:48.359
<v Speaker 3>Well, this is a great question which is exactly what

0:20:48.359 --> 0:20:53.880
<v Speaker 3>I would expect for a fellow citizen of Virginia, which.

0:20:53.640 --> 0:20:57.479
<v Speaker 2>Is what a Virginian is this a Mitmonian.

0:20:57.320 --> 0:21:05.120
<v Speaker 1>Rich Mendian, Virginian. Richard is a Virginian, a fellow Virginia.

0:21:05.280 --> 0:21:07.720
<v Speaker 2>And Richard is doing something which I do all the time,

0:21:07.760 --> 0:21:10.240
<v Speaker 2>in which I love seeing in people, which is thinking

0:21:10.280 --> 0:21:13.040
<v Speaker 2>about how the universe could be different? Why is it

0:21:13.080 --> 0:21:15.320
<v Speaker 2>this way? And that's like one of the big questions

0:21:15.320 --> 0:21:18.359
<v Speaker 2>of science, that's why we do science to understand is

0:21:18.400 --> 0:21:22.159
<v Speaker 2>the way our universe works? An accident, is it happened

0:21:22.200 --> 0:21:25.600
<v Speaker 2>for a reason? Of those reasons important? Do they determine

0:21:25.600 --> 0:21:28.119
<v Speaker 2>why we're here? All these things help un rapper like

0:21:28.160 --> 0:21:31.199
<v Speaker 2>the context of our lives. So yeah, awesome, Robert, thank

0:21:31.240 --> 0:21:33.760
<v Speaker 2>you for thinking big. Or maybe Robert's just writing a

0:21:33.760 --> 0:21:35.200
<v Speaker 2>science fiction novel and need some.

0:21:35.200 --> 0:21:37.840
<v Speaker 3>Help and we're happy to do that too.

0:21:38.320 --> 0:21:41.120
<v Speaker 2>Yeah, no problem, no problem. Yeah, So this question has

0:21:41.119 --> 0:21:44.040
<v Speaker 2>a lot of angles. You could think about whether life

0:21:44.080 --> 0:21:46.680
<v Speaker 2>would have evolved if Earth never had a moon, or

0:21:46.720 --> 0:21:48.600
<v Speaker 2>you could think about what would happen if we lost

0:21:48.640 --> 0:21:51.480
<v Speaker 2>our moon. So I started with that one because it's

0:21:51.480 --> 0:21:54.320
<v Speaker 2>sort of like a fun science fiction scenario, like, Hey,

0:21:54.359 --> 0:21:56.800
<v Speaker 2>we have a moon, are we going to have it forever?

0:21:57.080 --> 0:21:59.520
<v Speaker 2>Is it possible we could lose our moon? And the

0:21:59.560 --> 0:22:02.359
<v Speaker 2>answer to that is yes. You know, people think about

0:22:02.359 --> 0:22:05.199
<v Speaker 2>the Solar System as sort of static and this slow

0:22:05.359 --> 0:22:08.760
<v Speaker 2>moving parade of planets around the Sun that's been happening forever,

0:22:09.160 --> 0:22:11.680
<v Speaker 2>But that's not true. The Solar System is kind of chaotic.

0:22:11.960 --> 0:22:15.520
<v Speaker 2>It's just on longer time scales than we mostly think about.

0:22:16.040 --> 0:22:17.640
<v Speaker 2>You know, the order of the planets we have today

0:22:17.720 --> 0:22:20.400
<v Speaker 2>is not the same order the planets we've had forever.

0:22:20.760 --> 0:22:23.880
<v Speaker 2>Planets have migrated in and then migrated out. There are

0:22:23.880 --> 0:22:27.280
<v Speaker 2>theories that we had another gas giant that when Jupiter

0:22:27.359 --> 0:22:29.560
<v Speaker 2>and Saturn migrated to the inner Solar System and then

0:22:29.640 --> 0:22:32.560
<v Speaker 2>back out, one of these was tossed into outer space.

0:22:32.600 --> 0:22:35.280
<v Speaker 2>So there might be like a lost sibling planet out there.

0:22:36.520 --> 0:22:38.280
<v Speaker 1>I like to imagine the noise it made as it

0:22:38.320 --> 0:22:39.719
<v Speaker 1>got flung out into space.

0:22:40.920 --> 0:22:48.159
<v Speaker 2>Why mean exactly? And maybe that planet had like the

0:22:48.160 --> 0:22:50.399
<v Speaker 2>best climate in the whole Solar System. Maybe the Solar

0:22:50.400 --> 0:22:54.479
<v Speaker 2>System lost its California in that interaction, And I'll never know.

0:22:54.760 --> 0:22:58.000
<v Speaker 2>That's fine, and so in a similar way, we could

0:22:58.080 --> 0:23:00.600
<v Speaker 2>lose our moon. You know, something could like hit the

0:23:00.640 --> 0:23:02.840
<v Speaker 2>Moon and deflect it and knock it out of orbit.

0:23:03.000 --> 0:23:07.520
<v Speaker 2>In fact, right now, scientists are tracking a new interstellar comet.

0:23:07.840 --> 0:23:10.520
<v Speaker 2>This is a piece of the universe that comes from

0:23:10.720 --> 0:23:13.960
<v Speaker 2>another star, like a big chunk of rock and ice

0:23:14.359 --> 0:23:17.880
<v Speaker 2>thrown out of another solar system that's passing through hours

0:23:18.280 --> 0:23:19.800
<v Speaker 2>and we don't think it's going to hit the Earth

0:23:19.960 --> 0:23:22.919
<v Speaker 2>or that close, but it's moving really really fast. And

0:23:22.960 --> 0:23:25.879
<v Speaker 2>if it did hit the Earth, wow, that would be devastating.

0:23:26.119 --> 0:23:28.639
<v Speaker 2>And if it hit the Moon, it could certainly knock

0:23:28.720 --> 0:23:29.680
<v Speaker 2>it out of orbit.

0:23:29.880 --> 0:23:30.080
<v Speaker 3>You know.

0:23:30.119 --> 0:23:32.879
<v Speaker 1>I remember when I heard that. My first thought was, oh,

0:23:32.880 --> 0:23:34.399
<v Speaker 1>all right, hitting the Moon. That would be like a

0:23:34.400 --> 0:23:36.640
<v Speaker 1>bummer for a lot of reasons, but that would be better.

0:23:36.680 --> 0:23:38.920
<v Speaker 1>And then I'm like, wait a minute, maybe that wouldn't

0:23:38.920 --> 0:23:40.720
<v Speaker 1>be better, or it would be better, but like not

0:23:41.080 --> 0:23:41.760
<v Speaker 1>much better.

0:23:42.000 --> 0:23:45.359
<v Speaker 2>Yeah. In fact, there's a great science fiction novel called

0:23:45.440 --> 0:23:50.720
<v Speaker 2>Seven Eves which starts out with some aliens basically destroying

0:23:50.720 --> 0:23:53.080
<v Speaker 2>our moon. It's never really explained how it happens, but

0:23:53.200 --> 0:23:55.080
<v Speaker 2>most of the book has to do with trying to

0:23:55.119 --> 0:23:57.520
<v Speaker 2>survive the destruction of the moon because if it turns

0:23:57.560 --> 0:24:00.439
<v Speaker 2>into rubble and then starts falling into Earth, filling the

0:24:00.480 --> 0:24:02.840
<v Speaker 2>atmosphere with this stuff, and you basically have a nuclear

0:24:02.880 --> 0:24:05.720
<v Speaker 2>holocaust on Earth. It's end of days kind of stuff.

0:24:06.080 --> 0:24:08.400
<v Speaker 2>So we don't want our moon to be obliterated into dust,

0:24:08.440 --> 0:24:10.800
<v Speaker 2>but it could also just be knocked out of our orbit.

0:24:10.840 --> 0:24:13.040
<v Speaker 2>We could just lose it and go wandering into the

0:24:13.080 --> 0:24:15.880
<v Speaker 2>Solar System. And so that lets us think about, like, well,

0:24:15.960 --> 0:24:18.800
<v Speaker 2>what would life be like on Earth if we didn't

0:24:19.040 --> 0:24:20.959
<v Speaker 2>explode the Moon, if it just sort of like drifted

0:24:21.000 --> 0:24:24.040
<v Speaker 2>away somehow. Well, the Moon plays a big role in

0:24:24.320 --> 0:24:27.600
<v Speaker 2>biological experience, right, Like we know, for example, that the

0:24:27.640 --> 0:24:31.000
<v Speaker 2>Moon causes tides right high tide and low tide. This

0:24:31.080 --> 0:24:33.920
<v Speaker 2>is because of gravitational tidal forces. That's why they're called

0:24:33.960 --> 0:24:36.440
<v Speaker 2>tidal forces. And the physics here is really fun and

0:24:36.520 --> 0:24:38.960
<v Speaker 2>it sounds complicated because it's gravity and all that stuff,

0:24:38.960 --> 0:24:41.119
<v Speaker 2>but it's pretty basic. You know, one side of the

0:24:41.160 --> 0:24:43.240
<v Speaker 2>Earth is closer to the Moon than the other side

0:24:43.240 --> 0:24:45.600
<v Speaker 2>of the Earth, and so the Moon's gravity pulls on

0:24:45.640 --> 0:24:48.880
<v Speaker 2>the Earth harder on the closer side than the further side,

0:24:49.080 --> 0:24:51.120
<v Speaker 2>So it turns to Earth into something like a football

0:24:51.160 --> 0:24:54.720
<v Speaker 2>instead of a sphere. It's like squeezing the earth, and

0:24:54.840 --> 0:24:56.920
<v Speaker 2>the water on the Earth is the squishiest bit, and

0:24:56.960 --> 0:24:59.639
<v Speaker 2>so it responds the most. Most people don't realize though,

0:24:59.680 --> 0:25:02.080
<v Speaker 2>that all of the Earth gets squeezed. They are these

0:25:02.119 --> 0:25:05.679
<v Speaker 2>things called land tides that move the distance of the

0:25:05.720 --> 0:25:09.600
<v Speaker 2>surface of the Earth relative to the center by meters. Yes,

0:25:09.680 --> 0:25:12.000
<v Speaker 2>as the Moon goes around the Earth, it squeezes and

0:25:12.040 --> 0:25:15.760
<v Speaker 2>massages the Earth changes its shape, not just the water,

0:25:15.840 --> 0:25:18.119
<v Speaker 2>but the land also changes its shape.

0:25:18.320 --> 0:25:21.679
<v Speaker 3>Lies. That's amazing.

0:25:23.000 --> 0:25:25.760
<v Speaker 2>Yes, these are lies propagated by flies that the government

0:25:25.840 --> 0:25:30.120
<v Speaker 2>drops over California, infected with conspiracy theories.

0:25:30.880 --> 0:25:32.320
<v Speaker 3>Why you could dropping worse things?

0:25:32.359 --> 0:25:36.720
<v Speaker 2>Probably, Yes, most people know about the moon's effect on

0:25:36.840 --> 0:25:39.200
<v Speaker 2>water tides, but not so much about the moon's effect

0:25:39.480 --> 0:25:43.399
<v Speaker 2>on the earth. Right. And also, the Sun gives us tides, right, Like,

0:25:43.440 --> 0:25:45.520
<v Speaker 2>the Sun is much further away, but it's also much

0:25:45.600 --> 0:25:48.200
<v Speaker 2>more massive, So if you got rid of the Moon,

0:25:48.280 --> 0:25:51.800
<v Speaker 2>we would still have tides. Right. Tides are combination of

0:25:51.840 --> 0:25:53.840
<v Speaker 2>the Sun's tides and the Moon's tides, which is one

0:25:53.880 --> 0:25:55.639
<v Speaker 2>reason why tides are complicated. Like if you look at

0:25:55.640 --> 0:25:58.159
<v Speaker 2>a tidal chart, it's never like it goes up, it

0:25:58.200 --> 0:25:59.639
<v Speaker 2>goes down. It goes up, it goes down. It's a

0:25:59.640 --> 0:26:02.280
<v Speaker 2>simple sid It's complicated. It goes up, it goes down,

0:26:02.320 --> 0:26:05.639
<v Speaker 2>it comes up less, it goes down more. It's really complicated.

0:26:05.680 --> 0:26:08.160
<v Speaker 2>And that's due to the Sun and the moon and

0:26:08.520 --> 0:26:11.760
<v Speaker 2>the shape of the inlets and stuff. Tides are really complicated.

0:26:11.880 --> 0:26:14.080
<v Speaker 2>Isaac Newton started working on them hundreds of years ago,

0:26:14.119 --> 0:26:15.800
<v Speaker 2>and it wasn't until like one hundred years ago or

0:26:15.880 --> 0:26:18.080
<v Speaker 2>so that we had a pretty solid understanding of the

0:26:18.119 --> 0:26:18.720
<v Speaker 2>physics there.

0:26:18.840 --> 0:26:23.840
<v Speaker 1>Tides made my PhD super confusing because I had, you know,

0:26:23.920 --> 0:26:25.679
<v Speaker 1>I had to go out and collect snails when the

0:26:25.720 --> 0:26:27.840
<v Speaker 1>tide was low, and I would always think like, oh,

0:26:28.040 --> 0:26:29.840
<v Speaker 1>I remember when the tide was the other day. I'm

0:26:29.880 --> 0:26:33.119
<v Speaker 1>going to extrapolate forward, and you know it was not

0:26:33.200 --> 0:26:34.679
<v Speaker 1>as predictable as I wanted it to be.

0:26:34.880 --> 0:26:38.879
<v Speaker 2>Yeah, I know, they're complicated, and people think that this

0:26:38.960 --> 0:26:43.400
<v Speaker 2>complexity might have really been important for the development of life.

0:26:43.480 --> 0:26:45.200
<v Speaker 2>Like number one, If you got rid of the tides,

0:26:45.320 --> 0:26:48.280
<v Speaker 2>a lot of life by the seashore would be very confused,

0:26:48.640 --> 0:26:50.600
<v Speaker 2>and a lot of assumptions they make and things they

0:26:50.600 --> 0:26:54.000
<v Speaker 2>rely on would be thrown into chaos. So the conditions

0:26:54.040 --> 0:26:56.760
<v Speaker 2>for life on Earth would be drastically different, and some

0:26:56.800 --> 0:26:58.840
<v Speaker 2>things would live and some things would not live. But

0:26:58.880 --> 0:27:01.879
<v Speaker 2>also historically will imagine that tides played a role in

0:27:01.920 --> 0:27:04.760
<v Speaker 2>the evolution of life, that when you're on the border

0:27:04.840 --> 0:27:07.560
<v Speaker 2>between fresh water and saltwater, you have these brackish water

0:27:07.600 --> 0:27:11.200
<v Speaker 2>systems and there's a lot of like mixing up that happens,

0:27:11.200 --> 0:27:13.880
<v Speaker 2>and you can imagine like water sloshing up into these

0:27:13.880 --> 0:27:16.800
<v Speaker 2>tide pools and mixing this bit of biochemistry. But that

0:27:16.840 --> 0:27:19.640
<v Speaker 2>bit of biochemistry, and maybe that's even plays a role

0:27:19.680 --> 0:27:23.320
<v Speaker 2>in abiogenesis. A lot of this is very speculative, right, like, hmm,

0:27:23.520 --> 0:27:26.360
<v Speaker 2>maybe this and this seems like a compelling story. None

0:27:26.359 --> 0:27:27.919
<v Speaker 2>of it is the kind of science where we can like,

0:27:28.200 --> 0:27:30.679
<v Speaker 2>let's do the experiment. Let's have an earth without a

0:27:30.720 --> 0:27:32.959
<v Speaker 2>moon and an Earth with moons, and let's see if

0:27:33.000 --> 0:27:35.520
<v Speaker 2>life starts more often. It's just sort of more like

0:27:35.560 --> 0:27:39.159
<v Speaker 2>a reasonable sounding story, And that doesn't make it like

0:27:39.280 --> 0:27:41.440
<v Speaker 2>non scientific. It just means, hey, this is the most

0:27:41.480 --> 0:27:43.479
<v Speaker 2>we can do right now, sort of think about it

0:27:43.520 --> 0:27:46.879
<v Speaker 2>clearly and try to imagine. So we don't know the

0:27:46.920 --> 0:27:49.400
<v Speaker 2>answer to like could life have evolved without a moon?

0:27:50.119 --> 0:27:53.320
<v Speaker 2>Would life evolve differently without a moon? But there are

0:27:53.520 --> 0:27:55.800
<v Speaker 2>strong arguments to make that it's certainly possible.

0:27:56.160 --> 0:28:00.920
<v Speaker 1>So estuaries are ecosystems where fresh water it's salt water.

0:28:01.400 --> 0:28:07.040
<v Speaker 1>If you didn't have the moon, would estuaries narrow, Yeah.

0:28:06.840 --> 0:28:08.840
<v Speaker 2>There'd be a narrower band there, right, because it'd be

0:28:08.920 --> 0:28:12.200
<v Speaker 2>less mixing, right, because the moon brings the salt water

0:28:12.359 --> 0:28:13.880
<v Speaker 2>up further into the fresh water.

0:28:14.040 --> 0:28:17.560
<v Speaker 1>Absolutely, estuaries play an important role for ecological services, and

0:28:17.720 --> 0:28:20.440
<v Speaker 1>they're economically important because they end up being places where

0:28:20.480 --> 0:28:22.640
<v Speaker 1>baby crabs and baby fish that we like to eat

0:28:23.040 --> 0:28:24.000
<v Speaker 1>start their lives.

0:28:24.680 --> 0:28:27.119
<v Speaker 3>So anyway, let's keep the moon there. I've decided.

0:28:28.720 --> 0:28:30.880
<v Speaker 2>The moon makes things yummy nice.

0:28:30.920 --> 0:28:33.200
<v Speaker 3>Yeah, sure, yeah, the moon makes yummy things.

0:28:33.440 --> 0:28:37.080
<v Speaker 2>And the moon also affects global weather in other ways

0:28:37.160 --> 0:28:40.920
<v Speaker 2>because it changes current patterns. You know, it helps stabilize

0:28:40.920 --> 0:28:43.760
<v Speaker 2>climates by mixing up the air. Like it's pulling on

0:28:43.880 --> 0:28:46.240
<v Speaker 2>the air as well, so it's not just water. Has

0:28:46.280 --> 0:28:49.480
<v Speaker 2>all sorts of effects on the air and on the land.

0:28:50.080 --> 0:28:53.080
<v Speaker 2>In addition, of course, the moon provides light at night, right,

0:28:53.160 --> 0:28:56.560
<v Speaker 2>It's like essentially huge mirror in space reflecting the Sun

0:28:57.200 --> 0:29:00.480
<v Speaker 2>down to Earth. And so any crater that like takes

0:29:00.520 --> 0:29:03.080
<v Speaker 2>advantage of a little bit of moonlighte for hunting is

0:29:03.120 --> 0:29:05.640
<v Speaker 2>going to be disadvantaged. There is another in the category

0:29:05.640 --> 0:29:08.360
<v Speaker 2>of like things would be different. We don't know exactly

0:29:08.400 --> 0:29:11.640
<v Speaker 2>what that would mean, but we can sort of speculate intelligently,

0:29:12.040 --> 0:29:14.960
<v Speaker 2>and it seems certain that it would dramatically change the

0:29:15.000 --> 0:29:15.880
<v Speaker 2>conditions for life.

0:29:16.840 --> 0:29:20.040
<v Speaker 1>Would it be good for our favorite creatures, which are rats,

0:29:20.560 --> 0:29:22.280
<v Speaker 1>that would it help them hide at night?

0:29:22.840 --> 0:29:24.440
<v Speaker 2>It would it be good for rats that are out

0:29:24.440 --> 0:29:27.480
<v Speaker 2>at night, especially because it would be bad for owls, right,

0:29:27.720 --> 0:29:30.400
<v Speaker 2>owls that do a lot of rat eating. But also

0:29:30.600 --> 0:29:33.480
<v Speaker 2>it would be good for astronomers. You know, having a

0:29:33.600 --> 0:29:35.640
<v Speaker 2>moon is really bad when you're on the ground with

0:29:35.680 --> 0:29:37.480
<v Speaker 2>your telescope and you want to look at some star

0:29:37.680 --> 0:29:41.120
<v Speaker 2>and then boom, you have this huge sun mirror shining

0:29:41.160 --> 0:29:44.240
<v Speaker 2>into your eyeballs. It's a lot harder to have dark nights.

0:29:44.480 --> 0:29:46.880
<v Speaker 2>So a lot of our dark knights are ruined by

0:29:46.920 --> 0:29:49.959
<v Speaker 2>a moon. So you know, maybe there's a conspiracy out

0:29:49.960 --> 0:29:52.040
<v Speaker 2>there among astronomers to get rid of the moon.

0:29:52.280 --> 0:29:56.760
<v Speaker 3>Hey guys, knock it off. Knock it off. We need

0:29:56.760 --> 0:29:57.160
<v Speaker 3>the moon.

0:29:57.600 --> 0:30:00.560
<v Speaker 2>And there's even more dramatic effects that the moon plays

0:30:00.600 --> 0:30:03.400
<v Speaker 2>on the Earth. It's not just the tides and not

0:30:03.480 --> 0:30:05.760
<v Speaker 2>just the air, it's not just the night, but the

0:30:05.800 --> 0:30:08.800
<v Speaker 2>Earth's rotation and tilt are strongly affected by the moon

0:30:09.240 --> 0:30:12.320
<v Speaker 2>because the moon is pretty big, like especially for our moon, right,

0:30:12.400 --> 0:30:14.760
<v Speaker 2>lots of moons in the Solar system are much smaller

0:30:14.800 --> 0:30:17.440
<v Speaker 2>than our moon, but our moon is big enough that

0:30:17.520 --> 0:30:21.160
<v Speaker 2>it carries a significant fraction of the angular energy of

0:30:21.200 --> 0:30:23.800
<v Speaker 2>the Earth Moon system. So people think that the Earth's

0:30:23.880 --> 0:30:27.320
<v Speaker 2>rotation itself is affected by having a moon, and that

0:30:27.400 --> 0:30:29.479
<v Speaker 2>the tilt of the Earth is sort of moderated by

0:30:29.480 --> 0:30:31.640
<v Speaker 2>the moon. So like if we didn't have a moon,

0:30:32.000 --> 0:30:35.200
<v Speaker 2>earth tilt might be even crazier, it might be much deeper.

0:30:35.440 --> 0:30:36.640
<v Speaker 3>That would affect seasons.

0:30:36.960 --> 0:30:39.760
<v Speaker 2>It absolutely would affect seasons. Or it could also have

0:30:39.840 --> 0:30:42.080
<v Speaker 2>no tilt, right, and we can end up with no seasons.

0:30:42.680 --> 0:30:45.800
<v Speaker 2>And so the Earth's rotation and the earth tilt is

0:30:45.840 --> 0:30:49.040
<v Speaker 2>a product of this balance between the Earth and the Moon.

0:30:49.560 --> 0:30:51.800
<v Speaker 2>And there's another fun thing that's happening there, which is

0:30:51.840 --> 0:30:54.480
<v Speaker 2>that as these two are sort of massaging each other

0:30:54.600 --> 0:30:58.200
<v Speaker 2>right tidal and they're using their angular momentum to massage

0:30:58.240 --> 0:31:00.280
<v Speaker 2>each other, and it takes some energy to sequi easy

0:31:00.320 --> 0:31:02.720
<v Speaker 2>the Earth into a football. As it does that, it's

0:31:02.760 --> 0:31:05.320
<v Speaker 2>losing some of its angry momentum, and so the Moon

0:31:05.400 --> 0:31:08.360
<v Speaker 2>is actually getting further and further away from us every year,

0:31:08.800 --> 0:31:11.680
<v Speaker 2>and not by like some tiny amount like microns or something.

0:31:11.840 --> 0:31:14.320
<v Speaker 2>It's happening by one centimeter per year.

0:31:15.080 --> 0:31:18.640
<v Speaker 1>I mean, that's still a tiny amount. I thought you

0:31:18.640 --> 0:31:21.560
<v Speaker 1>were gonna tell me like a mile a year or something,

0:31:21.600 --> 0:31:24.520
<v Speaker 1>but you know that. I'm still concerned because I'm Kelly,

0:31:24.560 --> 0:31:27.720
<v Speaker 1>and I'm concerned about everything. But like, the centimeter doesn't

0:31:27.720 --> 0:31:29.400
<v Speaker 1>sound like a lot. Convince me it's a lot.

0:31:29.600 --> 0:31:31.600
<v Speaker 2>Well, it's not a lot for a year, but if

0:31:31.600 --> 0:31:33.880
<v Speaker 2>you have a lot of years, that's a lot of centimeters.

0:31:34.320 --> 0:31:36.960
<v Speaker 2>Imagine what the Moon might have looked like a million

0:31:37.080 --> 0:31:40.440
<v Speaker 2>years ago or two million years ago. As our ancestors

0:31:40.480 --> 0:31:43.760
<v Speaker 2>are walking across the plains. They had a bigger moon

0:31:43.960 --> 0:31:45.280
<v Speaker 2>in their night than we did.

0:31:45.480 --> 0:31:47.440
<v Speaker 3>Dinosaurs saw a bigger moon.

0:31:47.560 --> 0:31:51.920
<v Speaker 2>Yes, exactly, that's kind of cool. Yeah, okay, Dinosaur astronomers

0:31:51.920 --> 0:31:54.160
<v Speaker 2>had an easier time understanding the surface of the Moon

0:31:54.400 --> 0:31:55.320
<v Speaker 2>because it was closer.

0:31:55.440 --> 0:31:56.880
<v Speaker 3>Now I care work.

0:31:56.960 --> 0:32:01.840
<v Speaker 1>Did dinosaur entomologists drop steril insects on Californians.

0:32:03.520 --> 0:32:07.920
<v Speaker 2>One of my favorite dinosaur stories is somebody who reconstructed

0:32:07.960 --> 0:32:11.320
<v Speaker 2>the path of the asteroid that hit the Earth sixty

0:32:11.320 --> 0:32:13.640
<v Speaker 2>five million years ago, and at least one of the

0:32:13.680 --> 0:32:17.800
<v Speaker 2>possible paths includes a close flyby before it actually hit,

0:32:18.280 --> 0:32:21.440
<v Speaker 2>So that means that dinosaur astronomers had plenty of warning.

0:32:21.600 --> 0:32:23.400
<v Speaker 2>Oh wow, they could have seen this thing in the

0:32:23.440 --> 0:32:27.320
<v Speaker 2>sky before it hit, like weeks beforehand and prepared. But man,

0:32:27.720 --> 0:32:30.280
<v Speaker 2>they didn't fund astronomy enough. So there's a lesson, folks,

0:32:30.320 --> 0:32:31.360
<v Speaker 2>fund astronomy.

0:32:32.080 --> 0:32:35.360
<v Speaker 1>That's right, Dinosaur NASA should have gotten a lot more money.

0:32:35.440 --> 0:32:37.520
<v Speaker 2>And on that note, you know, this interstellar commt is

0:32:37.520 --> 0:32:39.800
<v Speaker 2>fascinating and it's not going to hit the Earth, so

0:32:39.920 --> 0:32:42.840
<v Speaker 2>nobody should worry. But you know, if it was pointed

0:32:42.880 --> 0:32:45.400
<v Speaker 2>at the Earth, then we would have very little time

0:32:45.440 --> 0:32:48.080
<v Speaker 2>to do anything about it, which means we should be

0:32:48.120 --> 0:32:50.760
<v Speaker 2>getting ready to do something about it before we spot

0:32:50.800 --> 0:32:53.280
<v Speaker 2>these things. So like we really should be spending more

0:32:53.320 --> 0:32:57.040
<v Speaker 2>time and energy on Earth protective services if you ask me.

0:32:57.400 --> 0:33:01.520
<v Speaker 1>So that's that's two squares on your Bingo card if

0:33:01.560 --> 0:33:04.640
<v Speaker 1>you're not keeping track. There's a existential dread and more

0:33:04.680 --> 0:33:06.120
<v Speaker 1>funding for science.

0:33:06.320 --> 0:33:08.600
<v Speaker 2>Especially because these sins could be lobbed in our direction

0:33:08.720 --> 0:33:11.640
<v Speaker 2>by aliens. So there's another Bengo square.

0:33:11.400 --> 0:33:14.840
<v Speaker 1>Fo yep, yep, yeah, Oh sorry, we still got to

0:33:14.920 --> 0:33:16.240
<v Speaker 1>hit on cannibalism and poop.

0:33:16.600 --> 0:33:17.600
<v Speaker 3>We'll get there, all right.

0:33:17.640 --> 0:33:19.600
<v Speaker 2>So if we lost our moon, or if Earth never

0:33:19.680 --> 0:33:22.560
<v Speaker 2>had a moon, we're looking at a very different situation

0:33:22.720 --> 0:33:25.760
<v Speaker 2>for life. We know that life on Earth would change

0:33:25.760 --> 0:33:28.040
<v Speaker 2>a lot, or may have not evolved or could have

0:33:28.080 --> 0:33:31.840
<v Speaker 2>evolved very differently. I don't have any reason to believe this,

0:33:31.960 --> 0:33:34.400
<v Speaker 2>but my hunch is that if Earth didn't have a moon,

0:33:34.600 --> 0:33:36.479
<v Speaker 2>we still might have gotten life. It just would be

0:33:36.600 --> 0:33:39.680
<v Speaker 2>very different. You know, it's easy to say these conditions

0:33:39.680 --> 0:33:42.040
<v Speaker 2>were required for life to turn out as we know it.

0:33:42.480 --> 0:33:45.320
<v Speaker 2>Therefore life wouldn't have evolved if you don't have those conditions.

0:33:45.360 --> 0:33:47.320
<v Speaker 2>But I think it's also equally likely that life just

0:33:47.360 --> 0:33:49.680
<v Speaker 2>would have been weird or indifferent. But the other side

0:33:49.680 --> 0:33:52.040
<v Speaker 2>of Robert's question is not just losing our moon, but

0:33:52.080 --> 0:33:54.440
<v Speaker 2>what about more moons? What if Earth had two moons

0:33:54.480 --> 0:33:57.120
<v Speaker 2>or seven moons? What would that be like? And is

0:33:57.200 --> 0:34:00.160
<v Speaker 2>that possible? And yes, it is still possible at this

0:34:00.200 --> 0:34:02.800
<v Speaker 2>fairly mature stage in the Solar system to get more moons.

0:34:03.160 --> 0:34:05.480
<v Speaker 2>We think this happened a lot with Jupiter and Saturn,

0:34:05.520 --> 0:34:08.319
<v Speaker 2>for example, some of their moons were formed as the

0:34:08.360 --> 0:34:11.560
<v Speaker 2>planet's formed, sort of leftover stuff that was too far

0:34:11.680 --> 0:34:14.320
<v Speaker 2>out and moving too fast to fall into the planet,

0:34:14.520 --> 0:34:16.399
<v Speaker 2>sort of the same way the planets didn't fall into

0:34:16.440 --> 0:34:18.759
<v Speaker 2>the Sun. And these moons tend to orbit in the

0:34:18.760 --> 0:34:21.280
<v Speaker 2>plane of the Solar System. But some of the moons

0:34:21.320 --> 0:34:24.880
<v Speaker 2>have like wacky orbits, and this might be because they're captured.

0:34:25.080 --> 0:34:27.360
<v Speaker 2>They're just something that came by and the gravity of

0:34:27.400 --> 0:34:31.040
<v Speaker 2>Jupiter or Saturn grabbed onto it. And so the Earth

0:34:31.040 --> 0:34:34.040
<v Speaker 2>could do that too. You have some chunk of stuff

0:34:34.080 --> 0:34:36.200
<v Speaker 2>from another Solar System or from somewhere else in the

0:34:36.200 --> 0:34:38.160
<v Speaker 2>Solar System comes by at the right angle and the

0:34:38.200 --> 0:34:40.360
<v Speaker 2>right velocity, the Earth could grab it, and then we

0:34:40.360 --> 0:34:43.000
<v Speaker 2>could get two moons. Wow, and then we'd have even

0:34:43.120 --> 0:34:44.240
<v Speaker 2>wackier tides.

0:34:44.760 --> 0:34:48.320
<v Speaker 1>If you had to guess probabilistically, if something comes close

0:34:48.360 --> 0:34:50.600
<v Speaker 1>to Earth, yeah zero oh yeah, okay, so it would

0:34:50.640 --> 0:34:53.280
<v Speaker 1>be more likely to smack into us and do damage

0:34:53.280 --> 0:34:54.840
<v Speaker 1>then create another moon, right.

0:34:54.800 --> 0:34:58.280
<v Speaker 2>Yeah, absolutely, most likely it hits us or it totally

0:34:58.360 --> 0:35:00.440
<v Speaker 2>misses us. But to get captured, you need to have

0:35:00.480 --> 0:35:03.960
<v Speaker 2>exactly the right velocity and radius match, right, Like you know,

0:35:04.000 --> 0:35:06.600
<v Speaker 2>first your physics, you can do the orbital mechanics at

0:35:06.640 --> 0:35:09.440
<v Speaker 2>every radius from the Earth. You need a specific velocity

0:35:09.719 --> 0:35:12.239
<v Speaker 2>in order to be in orbit, and so those things

0:35:12.280 --> 0:35:14.120
<v Speaker 2>have to match, and the angle has to match, and

0:35:14.160 --> 0:35:17.120
<v Speaker 2>so yeah, it's unlikely, but you know, obviously it has happened.

0:35:17.360 --> 0:35:19.759
<v Speaker 2>There definitely are moons that have been captured, so it

0:35:19.760 --> 0:35:23.000
<v Speaker 2>could happen to us. Whoa, and so it would affect

0:35:23.040 --> 0:35:25.680
<v Speaker 2>the tides. They would be even more complicated for grad

0:35:25.719 --> 0:35:27.920
<v Speaker 2>students trying to plan their experiments.

0:35:27.400 --> 0:35:28.440
<v Speaker 3>Trying to go get snails.

0:35:28.520 --> 0:35:31.680
<v Speaker 2>Yeah, it could affect the Earth's tilt and spin if

0:35:31.680 --> 0:35:33.440
<v Speaker 2>it's a big thing, right, So it could have a

0:35:33.480 --> 0:35:37.120
<v Speaker 2>real impact. And those two moons then would have complicated interactions.

0:35:37.360 --> 0:35:40.160
<v Speaker 2>They could even like squeeze each other and induce, like

0:35:40.520 --> 0:35:42.919
<v Speaker 2>you know, stuff going on inside those moons. You could

0:35:43.000 --> 0:35:45.080
<v Speaker 2>end up with like a volcanic moon in the sky.

0:35:45.280 --> 0:35:46.480
<v Speaker 2>That would be pretty awesome.

0:35:46.600 --> 0:35:48.399
<v Speaker 3>Could we get a ring? Could they break each other

0:35:48.440 --> 0:35:49.520
<v Speaker 3>apart and give us some ring?

0:35:49.960 --> 0:35:53.040
<v Speaker 2>Absolutely? Yeah, the moon could destroy the other one, or

0:35:53.040 --> 0:35:54.640
<v Speaker 2>the other one could destroy the moon. We could end

0:35:54.719 --> 0:35:58.000
<v Speaker 2>up with a ring. It could be really fascinating. So

0:35:58.360 --> 0:36:00.759
<v Speaker 2>is this something you should worry about. It's unlikely that

0:36:00.800 --> 0:36:04.000
<v Speaker 2>we would lose our moon anytime in your lifetime or

0:36:04.080 --> 0:36:07.799
<v Speaker 2>your children's lifetime or the next thousand years. If we

0:36:07.880 --> 0:36:11.359
<v Speaker 2>lose the moon's pretty survivable. If the moon gets destroyed,

0:36:11.640 --> 0:36:14.120
<v Speaker 2>then yeah, you'll be glad you built that bunker. But

0:36:14.280 --> 0:36:16.359
<v Speaker 2>you know, I think you have bigger things to worry about.

0:36:16.400 --> 0:36:20.240
<v Speaker 2>I think you should be more worried about screwworm than moons.

0:36:20.080 --> 0:36:22.359
<v Speaker 3>And science funding.

0:36:22.560 --> 0:36:24.720
<v Speaker 2>All right, well, thanks very much for that question, Robert.

0:36:24.920 --> 0:36:27.040
<v Speaker 2>Let me know how your science fiction novel is turning.

0:36:26.840 --> 0:36:30.400
<v Speaker 5>Out awesome, Thank you guys. So basically, we don't know,

0:36:30.840 --> 0:36:32.960
<v Speaker 5>and I kind of love when this happens because it's

0:36:32.960 --> 0:36:35.080
<v Speaker 5>finding the edges of what we know and don't know,

0:36:35.160 --> 0:36:38.160
<v Speaker 5>and it just shines a light on areas of future research.

0:36:38.320 --> 0:36:41.600
<v Speaker 5>You know, maybe if we figure out how the moon

0:36:41.800 --> 0:36:46.120
<v Speaker 5>or moons might play a part in evolution, then that

0:36:46.239 --> 0:36:51.920
<v Speaker 5>might help future SETI type programs to search for exoplanets

0:36:51.960 --> 0:36:55.080
<v Speaker 5>with you know, only one moon if we find that

0:36:55.080 --> 0:36:59.200
<v Speaker 5>that's a critical part of you know, life creation, or

0:36:59.440 --> 0:37:02.320
<v Speaker 5>focus on planets that have moons and ignore the ones

0:37:02.320 --> 0:37:05.520
<v Speaker 5>that don't. Whatever that case is. But I appreciate it,

0:37:05.560 --> 0:37:09.400
<v Speaker 5>Thank you very much, and yay, go fund research.

0:37:29.120 --> 0:37:31.799
<v Speaker 2>All right, we're back and we're answering questions from listeners,

0:37:32.080 --> 0:37:35.080
<v Speaker 2>and we're going back from physics into the gross world

0:37:35.239 --> 0:37:41.040
<v Speaker 2>of biology. So finish up that snack before you listen

0:37:41.040 --> 0:37:42.160
<v Speaker 2>to the rest of this episode.

0:37:42.400 --> 0:37:45.160
<v Speaker 1>Let's listen to a fantastic question from Anthony.

0:37:45.840 --> 0:37:50.680
<v Speaker 4>Hello, Daniel and Kelly. I'm Anthony from Orlando, Florida. I

0:37:50.840 --> 0:37:53.600
<v Speaker 4>enjoy your podcast and learn a great deal from you both.

0:37:53.880 --> 0:37:58.640
<v Speaker 4>Your recent conversation on Preon's was fascinating and scary. I

0:37:58.640 --> 0:38:01.680
<v Speaker 4>believe there is a comment in that discussion on synthetic blood.

0:38:02.640 --> 0:38:05.919
<v Speaker 4>What is the progress in developing synthetic blood for general use?

0:38:06.239 --> 0:38:08.880
<v Speaker 4>Are we any closer to it being used? Would it

0:38:08.920 --> 0:38:12.200
<v Speaker 4>be universal or type like regular blood? Again, thank you

0:38:12.480 --> 0:38:13.840
<v Speaker 4>and love your podcast.

0:38:14.200 --> 0:38:16.920
<v Speaker 2>All right, Kelly, So what is blood anyway?

0:38:17.320 --> 0:38:21.600
<v Speaker 1>Yeah, so it's complicated. It's not It depends, but it's complicated.

0:38:22.480 --> 0:38:26.080
<v Speaker 1>So blood, depending on how you want to slice it,

0:38:26.120 --> 0:38:29.560
<v Speaker 1>blood can be three or more things. So one of

0:38:29.600 --> 0:38:32.880
<v Speaker 1>them is plasma. This is like the fluidy part of

0:38:32.920 --> 0:38:35.280
<v Speaker 1>your blood. It's something like fifty five percent of your blood.

0:38:35.480 --> 0:38:37.799
<v Speaker 2>I've never understood why do they call it plasma, because

0:38:37.840 --> 0:38:40.520
<v Speaker 2>to me, plasma is a gas that's been heated up

0:38:40.800 --> 0:38:43.840
<v Speaker 2>until you get ions. Is there some similarity between physics

0:38:43.880 --> 0:38:45.040
<v Speaker 2>plasma and blood plasma?

0:38:45.320 --> 0:38:47.319
<v Speaker 1>Gosh, you know, if I had to put money on it,

0:38:48.080 --> 0:38:54.680
<v Speaker 1>our plasma came first. So I don't know the answer,

0:38:54.960 --> 0:38:56.480
<v Speaker 1>but you guys probably stole it.

0:38:56.440 --> 0:38:58.680
<v Speaker 2>From us, fair fair.

0:38:58.960 --> 0:38:59.319
<v Speaker 3>All right.

0:38:59.440 --> 0:39:03.360
<v Speaker 1>So yeah, this it carries stuff around like electrolytes and

0:39:03.440 --> 0:39:07.919
<v Speaker 1>hormones and antibodies made by your immune system, and it's

0:39:08.040 --> 0:39:10.920
<v Speaker 1>the bulk of blood, like fifty five percent of blood.

0:39:11.680 --> 0:39:14.080
<v Speaker 1>It also carries around stuff that helps with coagulation, so

0:39:14.120 --> 0:39:16.279
<v Speaker 1>like when you get a cut and your cut sort

0:39:16.280 --> 0:39:19.160
<v Speaker 1>of clots up and makes a scam. And then about

0:39:19.200 --> 0:39:23.960
<v Speaker 1>forty four percent is red blood cells, and inside of

0:39:24.000 --> 0:39:27.920
<v Speaker 1>the red blood cells is hemoglobin, and hemoglobin is what

0:39:28.040 --> 0:39:31.680
<v Speaker 1>carries oxygen to different parts of your body. And then

0:39:31.719 --> 0:39:36.480
<v Speaker 1>the last part is platelets, and these are like little

0:39:36.520 --> 0:39:40.319
<v Speaker 1>parts of cells that are really important for coagulation and

0:39:40.840 --> 0:39:41.840
<v Speaker 1>clotting up wounds.

0:39:42.120 --> 0:39:44.360
<v Speaker 2>So as somebody who's naive about biology, I always imagine

0:39:44.360 --> 0:39:46.760
<v Speaker 2>the blood is like, you know, it's the circulatory system.

0:39:46.800 --> 0:39:49.439
<v Speaker 2>It's like the highway for the body. Everything that needs

0:39:49.480 --> 0:39:51.680
<v Speaker 2>to go from one place to another gets dumped into

0:39:51.680 --> 0:39:53.399
<v Speaker 2>the blood. And then somebody else pulls it out.

0:39:53.520 --> 0:39:53.719
<v Speaker 3>Yep.

0:39:53.760 --> 0:39:56.279
<v Speaker 2>And so we're talking about water, electrolytes andti bodies, red

0:39:56.280 --> 0:39:58.800
<v Speaker 2>blood cells, platelets. All this stuff is just flowing through

0:39:59.200 --> 0:40:01.280
<v Speaker 2>the blood and useful to some bits.

0:40:01.040 --> 0:40:01.520
<v Speaker 3>Of the body.

0:40:01.560 --> 0:40:02.000
<v Speaker 2>Is that fair?

0:40:02.160 --> 0:40:04.400
<v Speaker 3>Yes, Your blood vessels are the highway system move in

0:40:04.480 --> 0:40:05.200
<v Speaker 3>the blood around.

0:40:05.400 --> 0:40:07.360
<v Speaker 2>So then why do we have different types of blood

0:40:07.360 --> 0:40:10.120
<v Speaker 2>when it makes blood A or B or O or whatever.

0:40:10.360 --> 0:40:10.600
<v Speaker 3>Yeah?

0:40:10.719 --> 0:40:13.279
<v Speaker 1>Right, So we've known about this for a while, So

0:40:13.320 --> 0:40:15.560
<v Speaker 1>I'm just gonna quick back up into history. So for

0:40:15.600 --> 0:40:19.480
<v Speaker 1>a while, we were like infusing blood from dogs into people,

0:40:19.640 --> 0:40:21.640
<v Speaker 1>or blood from lambs into people. Actually I think it

0:40:21.640 --> 0:40:23.560
<v Speaker 1>was mostly lambs, and there was a bit of a

0:40:23.600 --> 0:40:26.879
<v Speaker 1>religious like lambs are sort of innocent, lamb of God

0:40:27.040 --> 0:40:29.160
<v Speaker 1>sort of thing, and so that's the right kind of

0:40:29.200 --> 0:40:31.480
<v Speaker 1>animal to be putting into our bodies. And so for

0:40:31.480 --> 0:40:34.600
<v Speaker 1>a while, lamb blood was going into people. But we

0:40:35.040 --> 0:40:38.160
<v Speaker 1>learned that not only is it bad to put blood

0:40:38.160 --> 0:40:42.040
<v Speaker 1>from other animals into humans, it can also be bad

0:40:42.120 --> 0:40:46.120
<v Speaker 1>to switch blood from one human to another. And Austrian

0:40:46.160 --> 0:40:50.760
<v Speaker 1>physician Karl Landsteiner in nineteen hundred started mixing up different

0:40:50.920 --> 0:40:53.080
<v Speaker 1>blood from different people and he was like, well, sometimes

0:40:53.080 --> 0:40:56.600
<v Speaker 1>when you mix blood together, it coagulates and sometimes it doesn't,

0:40:56.719 --> 0:40:59.120
<v Speaker 1>and it's always the same if you take blood from

0:40:59.400 --> 0:40:59.960
<v Speaker 1>He wasn't.

0:40:59.800 --> 0:41:01.880
<v Speaker 2>Doing his experiments in people. He was like doing this

0:41:01.960 --> 0:41:02.600
<v Speaker 2>in the lab.

0:41:02.480 --> 0:41:04.560
<v Speaker 1>As I understand it, he was extracting blood from people

0:41:04.600 --> 0:41:07.040
<v Speaker 1>in his lab and he was like, you know, if

0:41:07.080 --> 0:41:10.600
<v Speaker 1>you extract blood from person A in person B, every

0:41:10.600 --> 0:41:13.160
<v Speaker 1>time you do that and mix the bloods together, it clots.

0:41:13.280 --> 0:41:16.359
<v Speaker 1>But person a in person sees blood every time you

0:41:16.400 --> 0:41:18.239
<v Speaker 1>do it doesn't clot when you put them together. So

0:41:18.320 --> 0:41:20.880
<v Speaker 1>what the heck is going on there? And he eventually

0:41:20.880 --> 0:41:23.560
<v Speaker 1>gets the Nobel Prize in Physiology and Medicine for sort

0:41:23.560 --> 0:41:26.560
<v Speaker 1>of figuring this out. And the answer is that blood

0:41:26.719 --> 0:41:30.920
<v Speaker 1>have like proteins that are like sticking out on the cells,

0:41:31.640 --> 0:41:34.240
<v Speaker 1>and some people have different kinds of proteins than others.

0:41:34.320 --> 0:41:37.720
<v Speaker 1>And if two people have different proteins on their blood cells,

0:41:37.719 --> 0:41:40.160
<v Speaker 1>then your immune system will recognize it as foreign and

0:41:40.200 --> 0:41:40.719
<v Speaker 1>attack it.

0:41:40.800 --> 0:41:42.520
<v Speaker 2>And that's what the clots are. And the clots are

0:41:42.560 --> 0:41:44.040
<v Speaker 2>like the immune system clumping it up.

0:41:44.120 --> 0:41:47.439
<v Speaker 1>Yes, exactly, yeah, and so but so you asked why

0:41:47.440 --> 0:41:48.920
<v Speaker 1>do we have different blood types?

0:41:49.000 --> 0:41:51.239
<v Speaker 3>And the answer, we do not know.

0:41:52.080 --> 0:41:54.320
<v Speaker 1>And so for a while it was popular to postulate

0:41:54.360 --> 0:41:56.600
<v Speaker 1>that it had something to do with like our ancestry

0:41:56.600 --> 0:41:59.560
<v Speaker 1>and where we came from. Like type A blood is maybe,

0:42:00.080 --> 0:42:02.960
<v Speaker 1>you know, like hunter gatherers, and so those people actually

0:42:02.960 --> 0:42:05.640
<v Speaker 1>should be eating more of like a hunter gatherer diet

0:42:05.760 --> 0:42:07.080
<v Speaker 1>because their blood.

0:42:06.760 --> 0:42:09.040
<v Speaker 3>Is like that's what it evolved for.

0:42:10.080 --> 0:42:12.640
<v Speaker 1>But the answer is that blood types show up in

0:42:12.719 --> 0:42:16.840
<v Speaker 1>primates before humans. So you know, chimpanzees have blood types,

0:42:17.200 --> 0:42:20.279
<v Speaker 1>and we don't really understand it could have something to

0:42:20.320 --> 0:42:24.000
<v Speaker 1>do with differences in immune functioning. So you know, maybe

0:42:24.040 --> 0:42:27.360
<v Speaker 1>people with type A blood might be more susceptible to

0:42:27.400 --> 0:42:30.239
<v Speaker 1>some virus that sweeps through the population, and type B

0:42:30.239 --> 0:42:33.600
<v Speaker 1>blood would be less susceptible. And this variability popped up

0:42:33.640 --> 0:42:36.840
<v Speaker 1>at some point and then was retained because it helped

0:42:37.400 --> 0:42:40.759
<v Speaker 1>some parts of the population avoid diseases. But the answer is,

0:42:40.760 --> 0:42:44.160
<v Speaker 1>we really don't know. But it happened before humans came around, all.

0:42:44.120 --> 0:42:46.360
<v Speaker 2>Right, So then it can't be explained by for example,

0:42:46.600 --> 0:42:49.319
<v Speaker 2>I radiated flesh eating flies distributed on the population by

0:42:49.320 --> 0:42:49.840
<v Speaker 2>the government.

0:42:49.920 --> 0:42:52.759
<v Speaker 3>Guys, those flies that are radiated. It's a good thing.

0:42:53.120 --> 0:42:54.120
<v Speaker 3>It's a good thing.

0:42:54.280 --> 0:42:58.000
<v Speaker 1>The science is helping us. You Californians are always jumping

0:42:58.000 --> 0:42:59.080
<v Speaker 1>to conspiracy theories.

0:43:00.320 --> 0:43:04.080
<v Speaker 2>It's just so fun. It's just so easy. Now I

0:43:04.120 --> 0:43:06.720
<v Speaker 2>see why they do it.

0:43:06.719 --> 0:43:07.960
<v Speaker 3>It feels good, doesn't it.

0:43:08.320 --> 0:43:11.240
<v Speaker 2>Yeah, you don't need evidence, it just need a compelling story.

0:43:11.320 --> 0:43:14.000
<v Speaker 2>That's right, all right. So we have all these things

0:43:14.080 --> 0:43:17.359
<v Speaker 2>inside the blood. So why do we think about synthetic blood?

0:43:17.400 --> 0:43:19.440
<v Speaker 2>Why do people work on making fake blood?

0:43:19.760 --> 0:43:21.600
<v Speaker 1>So right now, what we do is we get blood

0:43:21.640 --> 0:43:24.600
<v Speaker 1>from donors, and that's great. And when you donate blood,

0:43:24.640 --> 0:43:26.800
<v Speaker 1>often what happens is your blood is sort of separated

0:43:26.840 --> 0:43:29.400
<v Speaker 1>out into different parts, the red blood cells, the plasma,

0:43:29.520 --> 0:43:31.920
<v Speaker 1>the platelets, and they can go to different people depending

0:43:32.000 --> 0:43:37.120
<v Speaker 1>on their need. A major need for blood, though, is trauma.

0:43:37.800 --> 0:43:39.239
<v Speaker 1>So you know, for example, if you get into a

0:43:39.239 --> 0:43:41.120
<v Speaker 1>car accident and you lose a lot of blood when

0:43:41.120 --> 0:43:43.520
<v Speaker 1>you get to the er, when you get into the ambulance,

0:43:43.560 --> 0:43:45.480
<v Speaker 1>they might want to try to increase the amount of

0:43:45.480 --> 0:43:48.120
<v Speaker 1>blood that you have, and so donated blood gets used

0:43:48.120 --> 0:43:51.880
<v Speaker 1>for that purpose. And then another important use for blood

0:43:52.000 --> 0:43:56.000
<v Speaker 1>is in wartime, and here it's particularly hard to transport

0:43:56.160 --> 0:43:59.239
<v Speaker 1>blood from blood banks back home because blood has a

0:43:59.280 --> 0:44:00.080
<v Speaker 1>shelf life.

0:44:00.360 --> 0:44:01.680
<v Speaker 3>So red blood.

0:44:01.360 --> 0:44:04.560
<v Speaker 1>Cells are good for you know, a bit more than

0:44:04.560 --> 0:44:06.600
<v Speaker 1>a month month and a half, depending on like where

0:44:06.640 --> 0:44:09.480
<v Speaker 1>you are and what their rules are. I think platelets

0:44:09.480 --> 0:44:13.239
<v Speaker 1>are good for something like a week. Uh, And so

0:44:13.600 --> 0:44:15.799
<v Speaker 1>this stuff isn't good indefinitely, and it takes a long

0:44:15.840 --> 0:44:18.560
<v Speaker 1>time to get it from a bank to overseas, for example,

0:44:18.560 --> 0:44:22.120
<v Speaker 1>if you're talking about a war situation, and so having

0:44:22.239 --> 0:44:25.880
<v Speaker 1>synthetic blood would be great not only for these situations

0:44:25.960 --> 0:44:27.560
<v Speaker 1>where you know it's hard to get the blood to

0:44:27.560 --> 0:44:29.880
<v Speaker 1>where it needs to go, but also every once in

0:44:29.920 --> 0:44:32.399
<v Speaker 1>a while we have shortages. So, for example, the Red

0:44:32.520 --> 0:44:36.400
<v Speaker 1>Cross has declared blood shortages at different times, and so

0:44:36.800 --> 0:44:38.919
<v Speaker 1>if you can't get enough blood from people, it would

0:44:38.960 --> 0:44:41.759
<v Speaker 1>be nice to have synthetic blood. And the purpose of

0:44:41.760 --> 0:44:44.439
<v Speaker 1>synthetic blood is really just to hold you over until

0:44:44.480 --> 0:44:46.279
<v Speaker 1>your body can start making your own.

0:44:46.520 --> 0:44:48.800
<v Speaker 2>Wouldn't it also be nice to have synthetic blood because

0:44:48.800 --> 0:44:51.440
<v Speaker 2>then you could prevent like the spread of blood borne diseases.

0:44:51.600 --> 0:44:54.359
<v Speaker 3>Right, Yeah, So I mean that's worth considering. But at

0:44:54.400 --> 0:44:55.479
<v Speaker 3>this point, we have.

0:44:55.600 --> 0:44:59.640
<v Speaker 1>A lot of complicated screening procedures to find out if

0:44:59.680 --> 0:45:03.160
<v Speaker 1>blood is carrying infections, and I believe that we extract out,

0:45:03.200 --> 0:45:05.760
<v Speaker 1>for example, white blood cells before you give people blood,

0:45:05.760 --> 0:45:08.279
<v Speaker 1>because white blood cells, you know, could be carrying things

0:45:08.360 --> 0:45:12.160
<v Speaker 1>like HIV, And so the probability that you pick up

0:45:12.200 --> 0:45:14.920
<v Speaker 1>a disease from a transfusion in the United States and

0:45:14.960 --> 0:45:17.920
<v Speaker 1>the UK is very low. It might be higher in

0:45:17.960 --> 0:45:20.080
<v Speaker 1>other parts of the world, but we're very careful about

0:45:20.080 --> 0:45:21.080
<v Speaker 1>screening it here.

0:45:21.360 --> 0:45:23.560
<v Speaker 2>Yeah, and so how do the various human blood types

0:45:23.920 --> 0:45:26.359
<v Speaker 2>connect to the question of like making synthetic blood where

0:45:26.360 --> 0:45:28.680
<v Speaker 2>we have to make several different synthetic blood types.

0:45:28.760 --> 0:45:30.719
<v Speaker 1>Well, so that's the great thing about synthetic blood is

0:45:30.760 --> 0:45:34.120
<v Speaker 1>hopefully you don't have to worry about typing anymore because

0:45:34.120 --> 0:45:37.359
<v Speaker 1>you can make synthetic blood that doesn't have those sort

0:45:37.360 --> 0:45:39.319
<v Speaker 1>of proteins sticking on the outside that are going to

0:45:39.320 --> 0:45:41.680
<v Speaker 1>attract the attention of the immune system. And so it

0:45:41.719 --> 0:45:44.080
<v Speaker 1>would be helpful for example, like you know, imagine there's

0:45:44.080 --> 0:45:47.400
<v Speaker 1>an accident and somebody whose blood type you don't know

0:45:48.239 --> 0:45:50.799
<v Speaker 1>is going to need a bunch of blood. I guess

0:45:50.880 --> 0:45:52.799
<v Speaker 1>you need to take all of the different kinds of

0:45:52.800 --> 0:45:54.560
<v Speaker 1>blood with you, and then you need to take the

0:45:54.640 --> 0:45:56.880
<v Speaker 1>time to get a small sample of blood from the

0:45:56.920 --> 0:46:00.160
<v Speaker 1>trauma patients to figure out what kind of blood they have,

0:46:00.280 --> 0:46:01.480
<v Speaker 1>or at least you need to make sure you've got

0:46:01.600 --> 0:46:04.239
<v Speaker 1>enough of the universal donor's blood, which is type O,

0:46:05.040 --> 0:46:06.719
<v Speaker 1>to bring with you. So it would be much less

0:46:06.719 --> 0:46:09.720
<v Speaker 1>complicated if you didn't have to worry about blood typing

0:46:09.760 --> 0:46:12.840
<v Speaker 1>at all, and you could just universally have a synthetic

0:46:12.880 --> 0:46:14.480
<v Speaker 1>blood that you could bring with you that was more

0:46:14.520 --> 0:46:17.480
<v Speaker 1>shelf stable. This would solve a lot of problems. So

0:46:18.480 --> 0:46:20.600
<v Speaker 1>most of the research so far has been done on

0:46:20.760 --> 0:46:24.359
<v Speaker 1>making synthetic red blood cells. So this is again about

0:46:24.360 --> 0:46:27.000
<v Speaker 1>forty five percent of what blood is made of. And

0:46:27.040 --> 0:46:30.280
<v Speaker 1>initially what they were doing was they just got hemoglobin,

0:46:31.239 --> 0:46:33.799
<v Speaker 1>which is the part that binds to the oxygen, and

0:46:33.880 --> 0:46:36.040
<v Speaker 1>they were putting hemoglobin in people. They were like, well,

0:46:36.040 --> 0:46:38.839
<v Speaker 1>the important thing is the oxygen transport in an emergency

0:46:38.880 --> 0:46:44.279
<v Speaker 1>to keep everything going. But hemoglobin interacts with other kinds

0:46:44.320 --> 0:46:47.720
<v Speaker 1>of oxygen in the body. So nitric oxide is used

0:46:47.719 --> 0:46:52.279
<v Speaker 1>by our blood vessels to control vasodilation and vasoconstrictions, so

0:46:52.360 --> 0:46:55.640
<v Speaker 1>essentially to control how open or closed your blood vessels are,

0:46:56.200 --> 0:46:59.200
<v Speaker 1>and so just putting hemoglobin in meant that the hemoglobin

0:46:59.280 --> 0:47:04.160
<v Speaker 1>could interact with the nitric oxide and could tinker with vasodilation.

0:47:04.560 --> 0:47:06.520
<v Speaker 1>That sounds bad, or at least that was what was

0:47:06.520 --> 0:47:09.040
<v Speaker 1>claimed by a meta analysis that sort of changed the

0:47:09.040 --> 0:47:11.840
<v Speaker 1>way the whole fields felt about these things. And so,

0:47:12.200 --> 0:47:15.720
<v Speaker 1>for example, there's a product called Hemopure which was developed

0:47:15.719 --> 0:47:20.000
<v Speaker 1>in the nineties and it's essentially a cow hemoglobin which

0:47:20.000 --> 0:47:24.400
<v Speaker 1>has been purified, and now it's only used in compassionate

0:47:24.480 --> 0:47:26.520
<v Speaker 1>use cases, like you absolutely need it to try to

0:47:26.560 --> 0:47:29.560
<v Speaker 1>save someone's life. But there's some concern about it, you know,

0:47:29.600 --> 0:47:32.920
<v Speaker 1>messing with vasodilation. But some doctors still use it, and

0:47:32.960 --> 0:47:35.759
<v Speaker 1>in fact, there are doctors who argue that, like, look,

0:47:35.760 --> 0:47:39.080
<v Speaker 1>this isn't actually a massive problem because people are only

0:47:39.160 --> 0:47:41.799
<v Speaker 1>using this for like a day or two before their

0:47:41.960 --> 0:47:44.879
<v Speaker 1>body can start making enough red blood cells to replace them.

0:47:44.920 --> 0:47:48.120
<v Speaker 1>This isn't a real long term problem. We're overreacting. But

0:47:49.080 --> 0:47:52.880
<v Speaker 1>the field has essentially decided that this pure hemoglobin route

0:47:52.920 --> 0:47:54.200
<v Speaker 1>is not the best way to go.

0:47:55.160 --> 0:47:55.920
<v Speaker 3>So what do you do.

0:47:56.680 --> 0:48:00.920
<v Speaker 1>So there's a new company called Erythromyre and they're making

0:48:01.000 --> 0:48:04.799
<v Speaker 1>a red blood cell analog. So essentially what they do

0:48:05.040 --> 0:48:08.239
<v Speaker 1>is they get hemoglobin. In this case, they are extracting

0:48:08.280 --> 0:48:11.759
<v Speaker 1>hemoglobin from blood that has been donated but is now

0:48:11.840 --> 0:48:14.480
<v Speaker 1>past its shelf life. So if that blood doesn't get

0:48:14.520 --> 0:48:17.720
<v Speaker 1>given to someone in time they take it, they remove

0:48:17.840 --> 0:48:21.080
<v Speaker 1>the red blood cell outer part, they extract the hemoglobin,

0:48:21.480 --> 0:48:25.880
<v Speaker 1>and then they put the hemoglobin in a lipid layer

0:48:25.960 --> 0:48:28.600
<v Speaker 1>that they have made, so they essentially like enclose it

0:48:28.960 --> 0:48:32.600
<v Speaker 1>in a tiny, fatty capsule. It's smaller than a usual

0:48:32.640 --> 0:48:36.320
<v Speaker 1>red blood cell, but it keeps the hemoglobin from interacting

0:48:36.320 --> 0:48:40.040
<v Speaker 1>with the nitric oxide and messing with the vasodilation stuff.

0:48:40.080 --> 0:48:43.399
<v Speaker 1>And this is actually a really clever molecule. So it's

0:48:43.480 --> 0:48:46.279
<v Speaker 1>pH sensitive, which is important. So when it goes to

0:48:46.320 --> 0:48:50.520
<v Speaker 1>the lungs and you have high pH, it allows oxygen

0:48:50.719 --> 0:48:53.480
<v Speaker 1>to bind to the hemoglobin, and then when you get

0:48:53.480 --> 0:48:55.359
<v Speaker 1>to the parts of your body that are in need

0:48:55.400 --> 0:48:58.360
<v Speaker 1>of oxygen, that ends up being a low pH environment

0:48:58.800 --> 0:49:01.640
<v Speaker 1>and the hemoglobin can let go of the oxygen and

0:49:01.640 --> 0:49:05.080
<v Speaker 1>the oxygen can go oxygenate your other cells like it

0:49:05.120 --> 0:49:07.960
<v Speaker 1>needs to, which is like kind of fascinating to me,

0:49:08.120 --> 0:49:10.080
<v Speaker 1>like what a cool thing to have been able to

0:49:10.120 --> 0:49:13.560
<v Speaker 1>figure out. And it's universal, so there's no compatibility problems.

0:49:13.560 --> 0:49:16.680
<v Speaker 1>You don't have to type a patient beforehand. It's a

0:49:16.760 --> 0:49:20.000
<v Speaker 1>freeze dried powder and so you mix it with saline,

0:49:20.040 --> 0:49:22.319
<v Speaker 1>so you essentially get this like plastic bag that with

0:49:22.400 --> 0:49:25.040
<v Speaker 1>the divider in the center, and you've got the like

0:49:25.080 --> 0:49:28.920
<v Speaker 1>freeze dried eurythromyr on one side and saline on the

0:49:28.960 --> 0:49:31.000
<v Speaker 1>other side, which is like salt water that's the same

0:49:31.040 --> 0:49:34.120
<v Speaker 1>sort of saltiness as our blood. And then you like

0:49:34.280 --> 0:49:37.359
<v Speaker 1>break the divider between them, you mix the whole bag up,

0:49:37.800 --> 0:49:40.799
<v Speaker 1>and now you've got red blood cells or you know,

0:49:40.880 --> 0:49:42.960
<v Speaker 1>synthetic red blood cells that you're ready to give to

0:49:43.000 --> 0:49:45.800
<v Speaker 1>a patient. And they're thinking this could be shelf stable

0:49:45.800 --> 0:49:46.680
<v Speaker 1>for up to two years.

0:49:46.880 --> 0:49:49.080
<v Speaker 2>And they've like tried this at works. It like actually

0:49:49.160 --> 0:49:50.680
<v Speaker 2>carries the oxygen the way that you need.

0:49:51.080 --> 0:49:54.960
<v Speaker 1>They have done experiments on animals and it seems to

0:49:54.960 --> 0:49:57.239
<v Speaker 1>be doing well in the animals, and it seems like

0:49:57.360 --> 0:50:01.160
<v Speaker 1>they're lipid case for the hema globin gets you know,

0:50:01.200 --> 0:50:03.600
<v Speaker 1>processed by the digestive system the way you would expect

0:50:03.600 --> 0:50:05.560
<v Speaker 1>it to and you sort of pee it out when

0:50:05.560 --> 0:50:08.600
<v Speaker 1>you're done with it. And so the animal studies so

0:50:08.800 --> 0:50:12.960
<v Speaker 1>far have been promising. And a lead guy on the

0:50:13.000 --> 0:50:16.440
<v Speaker 1>project is doctor Doctor, and so I feel like we

0:50:16.920 --> 0:50:20.040
<v Speaker 1>have to trust that this is being done well.

0:50:20.080 --> 0:50:22.240
<v Speaker 2>Like his last name is doctor and he's the title

0:50:22.239 --> 0:50:22.720
<v Speaker 2>of doctor.

0:50:22.920 --> 0:50:24.959
<v Speaker 3>That's exactly right, yes, And.

0:50:24.920 --> 0:50:26.680
<v Speaker 2>If he was at a German university, he could be

0:50:26.760 --> 0:50:28.640
<v Speaker 2>like doctor, professor, doctor doctor.

0:50:28.880 --> 0:50:32.640
<v Speaker 3>Yeah, yes, amazing, we should move him to Germany.

0:50:32.800 --> 0:50:35.680
<v Speaker 2>So I'm really surprised that you can replace red blood

0:50:35.680 --> 0:50:38.880
<v Speaker 2>cells with something so simple, like, aren't red blood cells complicated?

0:50:38.880 --> 0:50:41.440
<v Speaker 2>Aren't they doing something else? Is there anything else that

0:50:41.560 --> 0:50:43.920
<v Speaker 2>red blood cells aren't doing that we're not capturing with

0:50:44.040 --> 0:50:46.000
<v Speaker 2>just hemoglobin in a fatty drop.

0:50:46.360 --> 0:50:49.480
<v Speaker 1>Probably, but you really just need to keep someone alive

0:50:49.719 --> 0:50:52.120
<v Speaker 1>for like the again, for the time that it makes

0:50:52.160 --> 0:50:54.360
<v Speaker 1>for their bone marrow to make their own red blood cells.

0:50:54.360 --> 0:50:57.360
<v Speaker 1>And so this is definitely just a short term solution

0:50:57.560 --> 0:51:00.600
<v Speaker 1>to keep your heart kicking so that you have time to,

0:51:00.840 --> 0:51:02.799
<v Speaker 1>you know, do the recovery on your own.

0:51:03.200 --> 0:51:05.120
<v Speaker 2>This seems kind of amazing. Is this something you think

0:51:05.160 --> 0:51:07.640
<v Speaker 2>we're going to see in hospitals and trauma centers?

0:51:07.960 --> 0:51:11.200
<v Speaker 1>I think they're going to be starting experiments in humans

0:51:11.400 --> 0:51:14.160
<v Speaker 1>in the not too distant future, so it's possible we'll

0:51:14.200 --> 0:51:16.239
<v Speaker 1>see this. But this is really hard because like, who

0:51:16.239 --> 0:51:19.160
<v Speaker 1>do you decide to give it to first? It's going

0:51:19.200 --> 0:51:21.319
<v Speaker 1>to be tough to design the human trials because we

0:51:21.440 --> 0:51:24.200
<v Speaker 1>know that red blood cells donated from a human work,

0:51:24.400 --> 0:51:26.319
<v Speaker 1>and so figuring out the first person who you're going

0:51:26.400 --> 0:51:27.560
<v Speaker 1>to be like, oh.

0:51:27.440 --> 0:51:29.280
<v Speaker 3>No, you're in it. This is a trauma situation.

0:51:29.400 --> 0:51:30.680
<v Speaker 1>You might die, but we're going to give you this

0:51:30.719 --> 0:51:32.719
<v Speaker 1>experimental thing, even though we could give you this other

0:51:32.760 --> 0:51:35.400
<v Speaker 1>thing that we know would work. You know, that's a

0:51:35.440 --> 0:51:37.000
<v Speaker 1>little bit difficult, and so I'm sure they're going to

0:51:37.040 --> 0:51:39.239
<v Speaker 1>have a little bit of trouble designing and finding the

0:51:39.320 --> 0:51:41.319
<v Speaker 1>right population to try this on.

0:51:41.640 --> 0:51:44.600
<v Speaker 2>You can imagine the compassionate use. You could give this

0:51:44.640 --> 0:51:47.000
<v Speaker 2>to trauma centers and then when they are in a

0:51:47.040 --> 0:51:49.040
<v Speaker 2>situation where they just don't have blood and somebody's going

0:51:49.120 --> 0:51:51.279
<v Speaker 2>to die, they're like, all right, well let's dip into

0:51:51.280 --> 0:51:51.920
<v Speaker 2>the fake stuff.

0:51:52.200 --> 0:51:53.520
<v Speaker 3>Yes, absolutely, yep.

0:51:53.840 --> 0:51:56.439
<v Speaker 1>Or you could send it to folks who are out

0:51:56.480 --> 0:51:59.399
<v Speaker 1>at the front lines in a war and they might

0:51:59.400 --> 0:52:01.800
<v Speaker 1>not be able to to blood type someone or something

0:52:01.840 --> 0:52:04.080
<v Speaker 1>like that, so they can't tell and they might not

0:52:04.120 --> 0:52:06.719
<v Speaker 1>be able to get blood donations. And so yes, you

0:52:06.719 --> 0:52:10.279
<v Speaker 1>absolutely can't imagine situations where having this on hand as

0:52:10.280 --> 0:52:12.480
<v Speaker 1>a backup could get you the data.

0:52:12.239 --> 0:52:12.759
<v Speaker 3>That you need.

0:52:12.880 --> 0:52:14.920
<v Speaker 2>All right, and what about the rest of the blood,

0:52:14.920 --> 0:52:16.360
<v Speaker 2>what about synthetic platelets?

0:52:17.000 --> 0:52:20.120
<v Speaker 1>Yeah, so doctor Ashley Brown's lab at North Carolina State

0:52:20.200 --> 0:52:23.560
<v Speaker 1>University has a platelet like particle that is an animal

0:52:23.600 --> 0:52:26.399
<v Speaker 1>testing right now, and the animal tests have gone pretty well.

0:52:26.440 --> 0:52:28.440
<v Speaker 1>So essentially what they did was they've got this like

0:52:29.200 --> 0:52:32.600
<v Speaker 1>very tiny nanoparticle that they made and it's like a

0:52:32.680 --> 0:52:36.040
<v Speaker 1>tiny microgel, so it's sort of soft and squishy, and

0:52:36.040 --> 0:52:39.799
<v Speaker 1>they've attached to it a protein that binds with this

0:52:39.840 --> 0:52:42.719
<v Speaker 1>thing called fibrin. So when your body starts to make

0:52:42.719 --> 0:52:45.919
<v Speaker 1>a clot, fibrin is a protein that's used to sort

0:52:45.960 --> 0:52:49.319
<v Speaker 1>of get that clot sticking together, and so essentially your

0:52:49.320 --> 0:52:52.840
<v Speaker 1>body starts dealing with the wound and then you're putting

0:52:52.840 --> 0:52:55.120
<v Speaker 1>this stuff in there, which is going to bind with

0:52:55.160 --> 0:52:57.000
<v Speaker 1>the fibrin that's already in the clot, and it's going

0:52:57.080 --> 0:53:00.160
<v Speaker 1>to move the clotting process along more quickly. So it

0:53:00.239 --> 0:53:04.320
<v Speaker 1>essentially finds where clots are forming by having this antibody

0:53:04.760 --> 0:53:07.799
<v Speaker 1>that binds with something you find in clots, or at

0:53:07.880 --> 0:53:10.440
<v Speaker 1>least that's my understanding. And so they did it in

0:53:10.560 --> 0:53:13.759
<v Speaker 1>mice and pigs and things went well. They said that

0:53:13.800 --> 0:53:16.160
<v Speaker 1>they might be a few years before human trials, and

0:53:16.200 --> 0:53:18.840
<v Speaker 1>there's things that they want to do, like get clumping

0:53:18.920 --> 0:53:21.880
<v Speaker 1>to work a little bit better. And this is definitely

0:53:21.920 --> 0:53:25.480
<v Speaker 1>not like, oh hey, we have created platelets again, and

0:53:25.560 --> 0:53:27.800
<v Speaker 1>everything that platelets do we're able to do with the

0:53:27.840 --> 0:53:30.880
<v Speaker 1>synthetic product. But it could be a really good measure

0:53:30.960 --> 0:53:33.040
<v Speaker 1>for like again, you know, there's a trauma situation. You

0:53:33.239 --> 0:53:34.960
<v Speaker 1>just got to get somebody to the point where their

0:53:34.960 --> 0:53:37.839
<v Speaker 1>body can recover and take over this work on its own.

0:53:38.400 --> 0:53:41.920
<v Speaker 1>And so anyway, so the take home, Anthony wanted to

0:53:41.960 --> 0:53:45.919
<v Speaker 1>know how close are we and the answer is that

0:53:46.000 --> 0:53:49.480
<v Speaker 1>we've got synthetic blood components that are being tested in

0:53:49.600 --> 0:53:53.160
<v Speaker 1>non human animals, and the current designs would be universal

0:53:53.320 --> 0:53:56.640
<v Speaker 1>if they work out. But we're mostly in the trial phase,

0:53:56.920 --> 0:53:59.960
<v Speaker 1>and so we're still relying on blood from human donors

0:54:00.120 --> 0:54:02.600
<v Speaker 1>more than anything else. There are some other products on

0:54:02.640 --> 0:54:04.319
<v Speaker 1>the market that we didn't talk about, but sort of

0:54:04.360 --> 0:54:06.799
<v Speaker 1>in general, at the moment, we are mostly relying on

0:54:06.880 --> 0:54:10.520
<v Speaker 1>human donors. And I'm sorry for all the vampires out there.

0:54:10.960 --> 0:54:14.600
<v Speaker 1>Still have some work left to do. True blood is

0:54:14.640 --> 0:54:15.439
<v Speaker 1>not ready yet.

0:54:15.560 --> 0:54:17.520
<v Speaker 2>I'm so glad you made a vampire joke, because I

0:54:17.560 --> 0:54:19.640
<v Speaker 2>feel bad I fell down on the opportunity to make

0:54:19.640 --> 0:54:22.440
<v Speaker 2>a were wolf joke in the moon question, you know.

0:54:22.960 --> 0:54:25.600
<v Speaker 1>I know, so, Oh my gosh, Daniel we could have

0:54:25.600 --> 0:54:28.839
<v Speaker 1>had zombies and werewolves and you know what, let's let's

0:54:28.840 --> 0:54:29.719
<v Speaker 1>start recording again.

0:54:29.760 --> 0:54:30.760
<v Speaker 3>We're going to do this again.

0:54:33.520 --> 0:54:36.080
<v Speaker 2>All right. Well, that's exciting, and I'm also sort of surprised.

0:54:36.120 --> 0:54:38.480
<v Speaker 2>You're sort of like optimistic and upbeat about this. This

0:54:38.520 --> 0:54:42.800
<v Speaker 2>seems like great news. Have you spent some time in

0:54:42.840 --> 0:54:44.520
<v Speaker 2>California recently? What's going on now?

0:54:44.800 --> 0:54:47.680
<v Speaker 1>I'm surprised too. You know, I didn't get enough sleep

0:54:47.719 --> 0:54:50.680
<v Speaker 1>and you know the all right here, let's go ahead

0:54:50.680 --> 0:54:52.320
<v Speaker 1>and we'll do the Kelly treatment a.

0:54:52.440 --> 0:54:52.560
<v Speaker 2>Right.

0:54:52.880 --> 0:54:54.879
<v Speaker 1>It should be worth noting that we have tried things

0:54:54.920 --> 0:54:57.720
<v Speaker 1>in the past that have not stuck. So for example,

0:54:57.760 --> 0:55:01.040
<v Speaker 1>you know that the straight up hemoglobin without a like

0:55:01.120 --> 0:55:03.920
<v Speaker 1>lipid layer, you know, we was tried and we ended

0:55:04.000 --> 0:55:05.920
<v Speaker 1>up deciding this is not really the solution for us.

0:55:05.920 --> 0:55:08.359
<v Speaker 1>So it's possible that will happen with these other things

0:55:08.400 --> 0:55:11.520
<v Speaker 1>that we talked about today too. So there's the Kelly treatments,

0:55:11.800 --> 0:55:12.600
<v Speaker 1>all right.

0:55:12.560 --> 0:55:14.799
<v Speaker 2>A little bit of cold water. But yeah, on the whole,

0:55:14.880 --> 0:55:15.880
<v Speaker 2>this seems very promising.

0:55:16.040 --> 0:55:17.320
<v Speaker 3>Yeah it does. It doesn't.

0:55:17.360 --> 0:55:19.520
<v Speaker 1>So I am really looking forward to when the vampires

0:55:19.520 --> 0:55:22.839
<v Speaker 1>can come out of hiding and we can start dating them.

0:55:25.760 --> 0:55:26.040
<v Speaker 2>Yay.

0:55:26.160 --> 0:55:30.680
<v Speaker 1>Science that's right, that's right.

0:55:30.080 --> 0:55:32.640
<v Speaker 2>All right. Well let's see what Anthony thinks about our

0:55:32.719 --> 0:55:34.520
<v Speaker 2>answer on synthetic blood.

0:55:35.000 --> 0:55:37.799
<v Speaker 4>Daniel and Kelly, as usual, you guys knocked it out

0:55:37.800 --> 0:55:41.399
<v Speaker 4>the park. I appreciate your answers. I learned a great deal.

0:55:42.080 --> 0:55:44.560
<v Speaker 4>I was particularly interested in this because I have relatives

0:55:44.560 --> 0:55:49.800
<v Speaker 4>whose religious convictions would prevent them from accepting blood transfusions. Perhaps,

0:55:50.080 --> 0:55:53.000
<v Speaker 4>as this science develops, they'll have another choice, or an

0:55:53.000 --> 0:55:57.520
<v Speaker 4>alternate decision that can save their lives. Possibly. I appreciate

0:55:57.560 --> 0:55:59.480
<v Speaker 4>your answers, love your podcast.

0:55:59.719 --> 0:56:01.960
<v Speaker 2>Thank you, thank you, Okay, thank you everybody for these

0:56:02.000 --> 0:56:05.080
<v Speaker 2>wonderful questions. We love hearing from you. Please do write

0:56:05.080 --> 0:56:07.120
<v Speaker 2>to us two questions at Daniel and Kelly dot org.

0:56:07.160 --> 0:56:09.120
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0:56:09.160 --> 0:56:11.239
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0:56:13.040 --> 0:56:17.680
<v Speaker 3>We look forward to hearing from you. Have a good one.

0:56:22.040 --> 0:56:25.600
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