WEBVTT - Scientists trail a  potential game-changer in diabetes treatment

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<v Speaker 1>Diabetes ever been a contender for type two?

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<v Speaker 2>Just eat mate, you'll get get to fix meat yep,

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<v Speaker 2>eat more fats, right. Cholesterol, Get cholesterol in you that

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<v Speaker 2>will fix your diabetes. Get cholesterols into you, India, get

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<v Speaker 2>cholesterol into you that'll fix your diabetes.

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<v Speaker 1>Well, I think we might have a chat with Professor

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<v Speaker 1>Alif Akinschi, who's from the Australian Senate for Accelerating Diabetes

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<v Speaker 1>Innovations at the University of Melbourne, because they've got a

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<v Speaker 1>new way to treat diabetes type two, which I've fan

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<v Speaker 1>quite fascinating. Professor, Good morning.

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<v Speaker 3>Good morning, Thanks for inviting me.

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<v Speaker 1>No worries. What's the best way to avoid diabetes type two?

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<v Speaker 1>First up?

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<v Speaker 3>So the best way really is to think about lifestyle measures,

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<v Speaker 3>so really increasing physical activity, eating healthy diet, avoiding ultra

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<v Speaker 3>process foods, avoiding sugar drinks and so forth. That is

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<v Speaker 3>really the best way to prevent getting diabetes in the

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<v Speaker 3>first place. It's also highly relevant if you do have diabetes, right.

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<v Speaker 1>Insulin injections can be very d traumatic, particularly for people

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<v Speaker 1>when they're knew to diabetes too, but you're working on

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<v Speaker 1>trying to avoid those Is that correct?

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<v Speaker 3>Yeah, there is a clinical trial that we did, which

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<v Speaker 3>we did the first phase, first in human clinical trial

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<v Speaker 3>at the Austin which is a hospital where I work at,

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<v Speaker 3>and I'm presenting the trial results at the American Diabetes

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<v Speaker 3>Association meeting in Chicago this week. And in that trial,

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<v Speaker 3>what we did was using electrical pulses to regenerate the

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<v Speaker 3>lining of the duodenum. So it's through an endoscopic procedure,

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<v Speaker 3>like a gastroscopy type of procedure, which is requiring a

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<v Speaker 3>general anesthetic. It lasts about an hour and a catheter

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<v Speaker 3>goes into the duodenal wall and it produces electrical pulses

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<v Speaker 3>which is really used to eliminate the poorly functioning cells

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<v Speaker 3>and that allows the regrowth of the new and healthy

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<v Speaker 3>cells usually within days. That helps the body make its

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<v Speaker 3>own hormones that are really relevant to help manage the datiatis.

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<v Speaker 4>So these are essentially for the layman out there, regenerating

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<v Speaker 4>the cells in your.

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<v Speaker 3>Gut, that's right. Yeah.

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<v Speaker 4>And so with the treatment, how say invasive is it

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<v Speaker 4>for a potential patient?

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<v Speaker 3>Yeah, so it is an invasive procedure because you need

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<v Speaker 3>a gastroscopy, you know, and a general anesthetic. But it

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<v Speaker 3>is being generally well tolerated. For the patients that we've

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<v Speaker 3>had in our trial, they go home on the same

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<v Speaker 3>day they have the treatment and you know, a few

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<v Speaker 3>days later and weeks later, the glucose levels improved. It it

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<v Speaker 3>is sort of like a regenerative procedure of the lining

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<v Speaker 3>of the small gut, particularly in the first part joodenum.

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<v Speaker 4>So with that treatment though, but going back to your

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<v Speaker 4>initial point, if you cut out the sugars, reduced carbohydrates,

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<v Speaker 4>as much as you can donate your process foods, healthy fats,

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<v Speaker 4>these are all keys to making sure your gut healthy.

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<v Speaker 3>Is good exactly. Yeah, they're they're really important things. So

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<v Speaker 3>in some people though, when they've had diabetes for a

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<v Speaker 3>long time, their management using medications or those injections like

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<v Speaker 3>a zembic or insulance is just not enough to keep

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<v Speaker 3>the blood sugars still under control. And so this is

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<v Speaker 3>a new way of thinking about treatment that could really

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<v Speaker 3>help people in that situation.

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<v Speaker 1>How excited are you, bidily, Yeah, we're pretty excited.

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<v Speaker 3>It's you know, first in the world really to show this,

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<v Speaker 3>and you know, us and at the Austin at Saint

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<v Speaker 3>Vincents in Melbourne and investigators that in Sydney and it

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<v Speaker 3>is really exciting. Now it's an international trial, which is

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<v Speaker 3>the next phase, which is a pivotal trial, and it's

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<v Speaker 3>recruiting at the moment and if people wanted to find out,

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<v Speaker 3>they can go to www. Dot reset study dot com.

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<v Speaker 3>It's R E. C to study dot com. And you know,

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<v Speaker 3>I think look at is early days. It is we

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<v Speaker 3>need to do more trial than this. The next phase

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<v Speaker 3>of the trial is a randomized control trial, which is

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<v Speaker 3>you know, the dummy controlled one, which is really important

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<v Speaker 3>for us to really know if this is working. But yeah,

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<v Speaker 3>we're quite excited about it.

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<v Speaker 1>Good on your best of luck you've made in Chicago before.

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<v Speaker 3>Yes, I have yes beautiful architecture.

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<v Speaker 1>Yeah, I come ale to enjoy it. Mate, we'll talk

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<v Speaker 1>against and good luck with the good luck with the study.