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Speaker 1: Now are company trialing a male contraceptive pill here in

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Speaker 1: New Zealand is looking for candidates. So they want men

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Speaker 1: age between twenty eight and seventy who do not want

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Speaker 1: to have kids in the future, and they are prepared

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Speaker 1: to pay twelve thousand dollars. The company leading the trial

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Speaker 1: is New Zealand Clinical Research and the lead research physician

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Speaker 1: is doctor rohit.

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Speaker 2: Cartil Hi Roe hit Hi Heather, how are you.

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Speaker 1: I'm very well, thank you. So what is it that

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Speaker 1: you want the participants to do?

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Speaker 3: So the study is quite interesting, but basically as part

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Speaker 3: of the trial they will have in patients to stay

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Speaker 3: with us, which lasts about seven nights, and then after

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Speaker 3: that they have follow up visits for up to a year.

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Speaker 3: And as part of those follow up visits we will

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Speaker 3: be collecting some scene examples as well.

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Speaker 1: Why do they have to stay with you for seven nights?

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Speaker 3: So that's just for monitoring. So at the basically it

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Speaker 3: takes a while for the drug to get to the

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Speaker 3: sort of peak concentration levels, and while it's getting up

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Speaker 3: to that amount, we want to monitor them and make

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Speaker 3: sure that there's no unexpected side effect.

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Speaker 1: Okay, and so is this like a women's contraceptive where

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Speaker 1: you take a pill every night.

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Speaker 3: So though that's what we're aiming to get to, obviously

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Speaker 3: it's still very early phase. So ideally it would be

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Speaker 3: a pill that's taken month's day, maybe twice a day.

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Speaker 3: So yeah, essentially that's what we're trying to get to.

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Speaker 1: And then then how long does it last for the effects?

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Speaker 1: Is it twelve hours?

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Speaker 2: Then?

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Speaker 3: So it's hard it's because we're in the early stage.

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Speaker 3: Is still it's hard to know exactly because the way

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Speaker 3: men's sperm cycles work and things that's a bit different.

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Speaker 3: So even though you might stop taking the drug, it

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Speaker 3: might take a bit longer for the sperm levels to

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Speaker 3: come back up. So all of that will be monitored

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Speaker 3: as part of the trial to see how long the

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Speaker 3: effects last and things like that.

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Speaker 1: And then I'm assuming that the test that you're asking

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Speaker 1: them to do is essentially, once they're released, go out

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Speaker 1: and you know, get with each other and see if

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Speaker 1: someone falls pregnant.

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Speaker 3: So basically the thing that we're using at the moment

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Speaker 3: is the of mail and fertility in term of sperm

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Speaker 3: counts and things like that. So if we can get

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Speaker 3: people down to those sort of sperm counts, they should

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Speaker 3: theoretically be infertile until the sperm counts come back.

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Speaker 1: Okay, so the test, Yeah yeah, so the test does

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Speaker 1: not go out and get with a lady and see

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Speaker 1: what happens. It is actually that you look at the

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Speaker 1: sperm you counted and you say, at this level, you

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Speaker 1: should not be able to have a child.

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Speaker 3: Yeah, exactly.

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Speaker 1: Okay, So what is it exactly that you are testing

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Speaker 1: this time around? Because you already know, I mean, you're

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Speaker 1: you're already reasonably confident, aren't you that the thing is safe?

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Speaker 1: So it's not a safety test.

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Speaker 3: So I guess the first study looked at safety testing

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Speaker 3: when participants got a single dose of the drug, But

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Speaker 3: obviously with a contraceptive, we're going to have to give

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Speaker 3: it sort of life long or however long the participants

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Speaker 3: or patients want to be on it. So this is

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Speaker 3: now testing multiple dosings, so when we're dosing it, you know,

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Speaker 3: day after day after day, to see what the safety

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Speaker 3: is like based on that.

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Speaker 1: Okay, and any already any concerns about side effect?

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Speaker 3: So no, no, nothing significant so far. Yeah.

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Speaker 1: Okay, Now do you think if this thing goes to market,

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Speaker 1: do you think women will trust it?

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Speaker 2: I'm not sure because this isn't this a fundamental problem

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Speaker 2: with the male contraceptive, which is the reason that women

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Speaker 2: take the female contraceptive is because we're going to be

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Speaker 2: the ones left carrying the can if something goes wrong.

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Speaker 1: So we are ensuring that we don't feel pregnant. But

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Speaker 1: now we're having to trust you dudes to tell us

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Speaker 1: nana's are good.

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Speaker 2: I took the pill.

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Speaker 1: What do you think?

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Speaker 3: I guess I guess the benefit here would be more

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Speaker 3: for the I guess the male and the relationship today

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Speaker 3: know that they be are taking their contraceptive if they

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Speaker 3: don't want to fall pregnant. I think women would probably

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Speaker 3: still continue to use their contraceptives as well.

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Speaker 1: Okay, I see, Okay, so this is so what we're

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Speaker 1: doing is we're saying you are you've basically got to

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Speaker 1: be responsible for yourself here, and we're giving men the

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Speaker 1: option to be responsible for themselves.

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Speaker 3: Yeah, and I guess I guess it's still very very

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Speaker 3: early stages. So well yes, yeah, well know once it

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Speaker 3: works that row it.

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Speaker 1: I mean, you must have women in your life, do

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Speaker 1: you reckon? Women in your life are going to trust

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Speaker 1: men to you know, do the right thing and take

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Speaker 1: it diligently every twelve hours.

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Speaker 3: Yeah, I guess like from my point of view, I would.

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Speaker 3: If I was a woman, I would still take my

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Speaker 3: own contraception, And if I was the nail, I would

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Speaker 3: take my own contraception too, if you get what I mean. Like,

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Speaker 3: if I was the now in the relationship and I

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Speaker 3: had an option, I would keep taking my contraceptive to

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Speaker 3: protect myself.

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Speaker 1: Very good advice, rowe it. Thanks very much, doctor Rohod Cartile,

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Speaker 1: New Zealand Clinical Research lead research physician. For more from

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