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Speaker 1: As if ozempic could not be any more of a

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Speaker 1: miracle drug, turns out there's more to it. It has now

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Speaker 1: been found to reduce the risk of strokes and heart

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Speaker 1: attacks by twenty percent and this is even in patients

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Speaker 1: who are not severely overweight to start with. This comes

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Speaker 1: from a study by the University College Auckland and is

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Speaker 1: prompted a London rather and is prompting suggestions that the

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Speaker 1: drug should not be restricted to only obese people. Peter

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Speaker 1: Shepherd is a molecular medicine professor at Auckland University and

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Speaker 1: an expert in diabetes and obesity and with us Hi

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Speaker 1: Peter Hi Heather, this is something of a wonder drug,

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Speaker 1: isn't it.

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Speaker 2: It's a pretty good one. Ozeenpic and semi glutide, which

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Speaker 2: is the active ingredient, is doing amazing things.

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Speaker 1: Okay, now, how do you explain this that it drops

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Speaker 1: this risk back in people who are not fat to

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Speaker 1: the eye.

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Speaker 2: Well, ozembic does, or semi glutide does a whole range

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Speaker 2: of things in our body apart from just controlling weight.

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Speaker 2: And we know that because it was originally developed as

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Speaker 2: a diabetes drug, and so even before it was showing

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Speaker 2: weight loss effects. It was controlling diabetes. So the effect

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Speaker 2: on the heart disease are partly through weight loss, but

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Speaker 2: there's clearly some other things happening that are slowing down

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Speaker 2: the rate of various aspects of heart disease. Do we

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Speaker 2: know what those other things are, Well, we know a

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Speaker 2: few of them, and we know a bit about how

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Speaker 2: it affects heart tissue growth. We know a bit about

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Speaker 2: some of the positive effects it has on the deposition

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Speaker 2: of lipids, but there's still a long way to go

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Speaker 2: to fully understand its effects, and more research will be needed.

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Speaker 1: How is this working so well for us as humans?

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Speaker 1: Is it replacing something that we do not have enough

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Speaker 1: of in our bodies?

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Speaker 2: Yeah, exactly. So. All it is is a hormone that's

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Speaker 2: been engineered to last longer in the body. Normally, in

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Speaker 2: our body, this hormon called GLP one gets broken down

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Speaker 2: really quickly by our body. And what we've done, or

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Speaker 2: what the drug companies have done here is make it

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Speaker 2: hang around longer and work longer and replace the effects

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Speaker 2: of that hormone in our body.

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Speaker 1: So with regards to loss, you only lose the weight

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Speaker 1: as long as you're taking the drug and the minute

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Speaker 1: that you stop taking the drug, the research shows you

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Speaker 1: start to put it back on again, and within a

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Speaker 1: couple of years you back to where you were beforehand.

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Speaker 1: Is the same true of all these other risks.

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Speaker 2: We actually don't know whether there will be a reversal

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Speaker 2: of the beneficial effects on cardiovascular disease and on a

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Speaker 2: kidney disease. No doubt they'll persist for quite a while,

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Speaker 2: but whether they are fully been reversed, we just don't

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Speaker 2: know yet. More time will tell.

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Speaker 1: Peter, I love the sound of this, but I am

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Speaker 1: reluctant to get myself too enthusiastic because it sounds like

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Speaker 1: it's a hideous thing to take.

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Speaker 2: What do you think, Well, it's not too bad, I

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Speaker 2: mean compared to a lot of the consequences that you

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Speaker 2: would otherwise have for most people. There are some people

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Speaker 2: who have side effects with it and go off and

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Speaker 2: won't take it any longer. But there are others who

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Speaker 2: really don't. So it depends, you know. I think when

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Speaker 2: the future, what we're going to find is that this

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Speaker 2: will benefit some people more than others. There'll be some people,

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Speaker 2: for whatever reason, whether it's their genetics or whatever about

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Speaker 2: that respond well to the drug. And it will be

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Speaker 2: useful for them and others who don't. I mean, we

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Speaker 2: know in the obesity side that some people respond incredibly

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Speaker 2: well to ozempic and others respond virtually not at all.

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Speaker 2: So I would take it. I probably need to take

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Speaker 2: it really.

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Speaker 1: Okay, So I had a baby in January, and I

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Speaker 1: wouldn't mind shreading for summer. Do you reckon? I should?

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Speaker 1: Shall I start now and then see how I look

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Speaker 1: on Christmas Day?

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Speaker 2: I think you should discuss that with your own GP.

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Speaker 2: I can't write your prescription right on.

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Speaker 1: The point now, but if you were my mate Sam,

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Speaker 1: we were just having a beer in the back garden,

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Speaker 1: what would you say.

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Speaker 2: I would say that that it's a good drug that

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Speaker 2: does many good things and for people who who will

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Speaker 2: truly benefit from it, it is a good way to go.

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Speaker 2: And I think in the future we're going to see

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Speaker 2: a lot wider use of this drug, especially as the

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Speaker 2: price comes down and things like you know, our government

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Speaker 2: system can afford afford this are We're going to see

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Speaker 2: much wider roll out of this type of drug.

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Speaker 1: So, yeah, Peter, thank you. Hope that helps you absolutely

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Speaker 1: it does, thank you. I'm just going to say, Peter

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Speaker 1: said it's fine. Peter Sheppard, molecular medicine professor at University

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Speaker 1: of Auckland.

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Speaker 2: news talks. It'd be from four pm weekdays, or follow

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