1 00:00:02,960 --> 00:00:07,920 Speaker 1: Welcome to Christian Natural Health with naturopathic doctor Lauren Deville. 2 00:00:08,200 --> 00:00:11,399 Speaker 1: Christian Natural Health is the podcast on how to get 3 00:00:11,440 --> 00:00:16,840 Speaker 1: and stay healthy God's Way. You'll hear topics on nutrition, exercise, sleep, 4 00:00:17,079 --> 00:00:22,680 Speaker 1: avoiding toxicity, meditating on scripture, what supplements to take, stress management, 5 00:00:23,000 --> 00:00:27,520 Speaker 1: defeating anxiety and worry, how to reconcile Eastern medicine approaches 6 00:00:27,520 --> 00:00:32,200 Speaker 1: with Christianity, and a whole lot more. Now here's your host, 7 00:00:32,440 --> 00:00:33,240 Speaker 1: doctor Lauren. 8 00:00:35,159 --> 00:00:38,000 Speaker 2: Welcome back to another episode of Christian Natural Health. Today. 9 00:00:38,040 --> 00:00:40,959 Speaker 2: I am going to be talking about the cell danger response. 10 00:00:41,560 --> 00:00:44,040 Speaker 2: As a naturopathic doctor, I am trained to think of 11 00:00:44,120 --> 00:00:47,480 Speaker 2: chronic disease in terms of the therapeutic order. Treatment has 12 00:00:47,479 --> 00:00:50,560 Speaker 2: to follow a particular sequence of steps for optimal results, 13 00:00:50,560 --> 00:00:52,720 Speaker 2: and the more sensitive the patient, the more critical this 14 00:00:52,840 --> 00:00:55,960 Speaker 2: sequence becomes. If you step on a foreign for instance, 15 00:00:56,000 --> 00:00:58,000 Speaker 2: it'll heart and your foot will swell up around the 16 00:00:58,040 --> 00:01:00,280 Speaker 2: area of the intruder in an attempt to expel it 17 00:01:00,400 --> 00:01:03,440 Speaker 2: and repair the damage. The appropriate treatment for this pain 18 00:01:03,560 --> 00:01:05,480 Speaker 2: isn't to take an advil and to try to forget 19 00:01:05,480 --> 00:01:07,440 Speaker 2: about it, or to ice the foot, or to just 20 00:01:07,560 --> 00:01:10,640 Speaker 2: use crutches. It's to pull out the thorn. Naturally in 21 00:01:10,760 --> 00:01:14,679 Speaker 2: chronic systemic disease. If the initial trigger is an external toxin, 22 00:01:14,880 --> 00:01:17,480 Speaker 2: first you have to get out of the toxic environment. 23 00:01:17,880 --> 00:01:20,160 Speaker 2: Once you've done that, the next step is to supply 24 00:01:20,280 --> 00:01:25,280 Speaker 2: any missing building blocks required for healing clean water, fresh air, sleep, exercise, 25 00:01:25,280 --> 00:01:28,679 Speaker 2: a healthy diet, etc. Sometimes this alone is enough to 26 00:01:28,720 --> 00:01:31,120 Speaker 2: restore health, and the healthier the person, the more often 27 00:01:31,160 --> 00:01:33,520 Speaker 2: this is the case, but sometimes subsequent steps in the 28 00:01:33,520 --> 00:01:37,800 Speaker 2: therapeutic order are still necessary. I recently became aware of 29 00:01:37,840 --> 00:01:40,319 Speaker 2: an analog of this process in the literature called the 30 00:01:40,360 --> 00:01:44,200 Speaker 2: cell danger response, described in multiple papers over the past 31 00:01:44,200 --> 00:01:47,000 Speaker 2: decade or so by Robert Neveau. It strikes me as 32 00:01:47,000 --> 00:01:49,480 Speaker 2: similar to the therapeutic order, but with a much more 33 00:01:49,600 --> 00:01:52,440 Speaker 2: robust description of what is happening at the cellular level. 34 00:01:52,520 --> 00:01:55,600 Speaker 2: Here's what it is. A healthy cell can typically deal 35 00:01:55,640 --> 00:01:58,360 Speaker 2: with minor damage during the normal sleep cycle, clearing out 36 00:01:58,360 --> 00:02:02,160 Speaker 2: metabolic waste and initiating cellsllular repair. The cell danger response 37 00:02:02,200 --> 00:02:05,960 Speaker 2: only gets triggered when the damage exceeds this threshold. Nevau 38 00:02:06,040 --> 00:02:09,360 Speaker 2: describes three stages of the CDR four if you include 39 00:02:09,400 --> 00:02:13,320 Speaker 2: restoration to health stage one. CDR one involves a cellular 40 00:02:13,400 --> 00:02:16,440 Speaker 2: disconnect from the organism at large, going offline as it were, 41 00:02:16,480 --> 00:02:19,919 Speaker 2: from a functional standpoint, as well as inflammation and energy 42 00:02:20,000 --> 00:02:23,320 Speaker 2: conservation to deal with the thread. Stage two CDR two 43 00:02:23,440 --> 00:02:27,079 Speaker 2: is the repair stage. Cells revert to undifferentiated stem cells 44 00:02:27,080 --> 00:02:31,000 Speaker 2: to proliferate and replace what's been damaged. Stage three CDR 45 00:02:31,080 --> 00:02:35,760 Speaker 2: three involves new cell differentiation and instructs regarding in instructions 46 00:02:35,760 --> 00:02:38,680 Speaker 2: regarding their new function in the tissue and organism as 47 00:02:38,720 --> 00:02:43,200 Speaker 2: a whole. Nevau described these stages via metabolomics, which is 48 00:02:43,240 --> 00:02:46,760 Speaker 2: a process by which many biological metabolites are measured at 49 00:02:46,760 --> 00:02:50,200 Speaker 2: once from a single tissue sample. This allows the researcher 50 00:02:50,240 --> 00:02:52,600 Speaker 2: to look for patterns, not single markers, to tell a 51 00:02:52,639 --> 00:02:55,959 Speaker 2: bigger story of what's going on after cellular damage occurs. 52 00:02:56,400 --> 00:02:59,480 Speaker 2: This is useful because it helps to reframe chronic illness 53 00:02:59,720 --> 00:03:02,280 Speaker 2: in terms of which stage of the CDR they might 54 00:03:02,320 --> 00:03:05,560 Speaker 2: be stuck in. This understanding may help to clarify which 55 00:03:05,639 --> 00:03:09,200 Speaker 2: specific therapeutic modalities might be warranted and in what sequence. 56 00:03:10,040 --> 00:03:13,440 Speaker 2: Many chronic diseases go back to mitochondrial dysfunction. But I've 57 00:03:13,440 --> 00:03:15,519 Speaker 2: noticed in practice that even when I have a good 58 00:03:15,520 --> 00:03:18,280 Speaker 2: reason to believe that this is the case, mitochondrial support 59 00:03:18,320 --> 00:03:21,680 Speaker 2: products or procedures in many cases yield less than impressive results. 60 00:03:22,080 --> 00:03:25,000 Speaker 2: The CDR concept helps to put in context why this 61 00:03:25,120 --> 00:03:28,520 Speaker 2: is the case. The mitochondria are where the CDR starts. 62 00:03:28,720 --> 00:03:31,639 Speaker 2: They sense a threat, be it physical, chemical, or infectious, 63 00:03:31,639 --> 00:03:35,200 Speaker 2: and they respond by spilling ATP, the body's energy currency 64 00:03:35,240 --> 00:03:38,520 Speaker 2: outside the cell, as well as various precursors and breakdown 65 00:03:38,560 --> 00:03:42,880 Speaker 2: products of ATP, such as ADP, oxygen, reactive oxygen species, 66 00:03:42,880 --> 00:03:47,920 Speaker 2: and other metabolites from further upstream. The mitochondria are bleeding out, essentially, 67 00:03:48,160 --> 00:03:51,600 Speaker 2: but they're doing it because continuing with business as usual 68 00:03:51,640 --> 00:03:54,320 Speaker 2: typical tissue function would ignore the threat and would likely 69 00:03:54,360 --> 00:03:57,440 Speaker 2: result in cell and tissue death. Sometimes cell death can 70 00:03:57,480 --> 00:04:00,480 Speaker 2: be the targeted healthy house cleaning autophogy, but that's not 71 00:04:00,520 --> 00:04:02,840 Speaker 2: what this would be. This is a threat against otherwise 72 00:04:02,880 --> 00:04:06,160 Speaker 2: healthy cells. In other words, this is cellular defense mode. 73 00:04:07,120 --> 00:04:10,920 Speaker 2: Typical metabolism in the mitochondria involves the conversion of glucose 74 00:04:10,960 --> 00:04:15,200 Speaker 2: into ATP with the help of oxygen. It's called oxidative phosphorylation, 75 00:04:15,320 --> 00:04:18,760 Speaker 2: and it's quite efficient. But in the stage of CDR IE, 76 00:04:18,839 --> 00:04:21,920 Speaker 2: the cell doesn't want to convert oxygen to ATP. For energy, 77 00:04:21,960 --> 00:04:23,800 Speaker 2: and indeed it's just gotten rid of its cache of 78 00:04:23,839 --> 00:04:27,719 Speaker 2: available ATP. Instead, it wants the oxygen to make reactive 79 00:04:27,720 --> 00:04:31,600 Speaker 2: oxygen species prooxidants to attack the danger source, whatever it is. 80 00:04:32,040 --> 00:04:35,239 Speaker 2: Nevau uses the analogy of converting the mitochondria from power 81 00:04:35,240 --> 00:04:37,960 Speaker 2: plants to battleships. The goal here is to get rid 82 00:04:38,040 --> 00:04:41,680 Speaker 2: of the eminent threat with minimal collateral damage. This still 83 00:04:41,720 --> 00:04:44,599 Speaker 2: requires some ATP, but not nearly as much as normal 84 00:04:44,640 --> 00:04:48,440 Speaker 2: tissue function, so the cell switches to anaerobic without oxygen respiration, 85 00:04:48,920 --> 00:04:53,520 Speaker 2: producing lactic acid as a byproduct. CDR two is the 86 00:04:53,560 --> 00:04:56,480 Speaker 2: second phase of the cell danger response. Once the acute 87 00:04:56,560 --> 00:05:00,000 Speaker 2: danger is gone, the next phase involves repairing and rep 88 00:05:00,080 --> 00:05:03,159 Speaker 2: placing any tissues damaged in the fight. Depending on the 89 00:05:03,160 --> 00:05:06,599 Speaker 2: tissue involved, sometimes local stem cells get activated and begin 90 00:05:06,680 --> 00:05:10,360 Speaker 2: the differentiation process In tissue is slower turnover, Mature cells 91 00:05:10,400 --> 00:05:12,839 Speaker 2: revert back to stem cells so that they can proliferate 92 00:05:12,880 --> 00:05:16,039 Speaker 2: and repair the damage. When this occurs, the mitochondria flip 93 00:05:16,160 --> 00:05:19,440 Speaker 2: back to aerobic with oxygen respiration, but not the typical 94 00:05:19,480 --> 00:05:23,560 Speaker 2: oxidative phosphorylation of a healthy cell. Instead, stem cells enter 95 00:05:23,680 --> 00:05:26,599 Speaker 2: Warburg metabolism, best known as the way that cancer cells 96 00:05:26,760 --> 00:05:31,200 Speaker 2: locally generate energy. All rapidly dividing cells do this because 97 00:05:31,279 --> 00:05:34,239 Speaker 2: what they need most is an energy for normal function. Rather, 98 00:05:34,360 --> 00:05:38,680 Speaker 2: they need building blocks to make more cells normal mitochondrial function. 99 00:05:38,720 --> 00:05:42,080 Speaker 2: Oxidati phosphorylation involves breaking glucose all the way down to 100 00:05:42,120 --> 00:05:44,560 Speaker 2: CO two, which we exhale, but that's a waste of 101 00:05:44,560 --> 00:05:46,960 Speaker 2: carbon for a cell that needs it for a building material. 102 00:05:47,240 --> 00:05:50,560 Speaker 2: In Warburg metabolism, oxygen is available, but the cell chooses 103 00:05:50,600 --> 00:05:54,000 Speaker 2: to make lactic acid instead. This is both to regenerate NAD, 104 00:05:54,320 --> 00:05:56,960 Speaker 2: the oxidized form of NADH, which is otherwise known as 105 00:05:57,000 --> 00:05:59,880 Speaker 2: vitamin B three, which is which is necessary to continue 106 00:05:59,920 --> 00:06:03,279 Speaker 2: to produce ATP, and also because lactate then can get 107 00:06:03,279 --> 00:06:07,480 Speaker 2: recycled into building blocks for the new cell. CDR three 108 00:06:07,560 --> 00:06:10,240 Speaker 2: the third phase. At this point, the new tissue is 109 00:06:10,240 --> 00:06:12,920 Speaker 2: built and the new cells differentiate into their roles and 110 00:06:13,040 --> 00:06:16,680 Speaker 2: establish connections with their neighbors. The mitochondria should flip out 111 00:06:16,720 --> 00:06:20,440 Speaker 2: of Warburg metabolism and back to oxidative phosphorylation. They should 112 00:06:20,440 --> 00:06:23,960 Speaker 2: also begin to restore sensitivity to outside signals like hormones 113 00:06:24,040 --> 00:06:26,640 Speaker 2: during the CDR cycles, since the cells are offline they 114 00:06:26,640 --> 00:06:31,680 Speaker 2: aren't sensitive to systemic hormonal signals. The main signal necessary 115 00:06:31,680 --> 00:06:34,880 Speaker 2: to bring tissues stuck in CDR three back to health 116 00:06:34,960 --> 00:06:39,320 Speaker 2: is signaling from the vagus nerve. Chronic CDR activation essentially 117 00:06:39,320 --> 00:06:42,560 Speaker 2: communicates to the body that it's not safe, inherently activating 118 00:06:42,600 --> 00:06:45,880 Speaker 2: the sympathetic nervous system and rendering the tissues resistant to 119 00:06:45,960 --> 00:06:48,880 Speaker 2: signals from the parasympathetic nervous system at the same time. 120 00:06:49,400 --> 00:06:52,279 Speaker 2: This likely explains why some people who are clearly locked 121 00:06:52,279 --> 00:06:55,240 Speaker 2: in a pattern of autonomic nervous system dysfunction don't always 122 00:06:55,240 --> 00:06:58,279 Speaker 2: respond to vagus nerve stimulation, somatic therapies and the like. 123 00:06:58,640 --> 00:07:00,719 Speaker 2: These therapies are designed to set the signal to the 124 00:07:00,720 --> 00:07:03,640 Speaker 2: body you're safe, you can function normally again. But this 125 00:07:03,720 --> 00:07:07,000 Speaker 2: will only work if the dysfunctional cells have completed CDR 126 00:07:07,080 --> 00:07:10,320 Speaker 2: three and are stuck there. If they're stuck anywhere upstream, 127 00:07:10,440 --> 00:07:12,840 Speaker 2: it's not either not true. Maybe the tissue isn't safe 128 00:07:12,880 --> 00:07:15,000 Speaker 2: if they're still in a toxic environment or struggling with 129 00:07:15,000 --> 00:07:18,240 Speaker 2: a rampant infection, or the signal can't yet get through. 130 00:07:19,680 --> 00:07:21,360 Speaker 2: So the second part of this I'm going to go 131 00:07:21,400 --> 00:07:24,280 Speaker 2: ahead and put in the same podcast. So just as 132 00:07:24,320 --> 00:07:27,640 Speaker 2: a quick summary the three phases of the cell danger response. 133 00:07:27,680 --> 00:07:30,440 Speaker 2: It's a cycle in which the cells take themselves offline 134 00:07:30,760 --> 00:07:32,800 Speaker 2: from the rest of the body in order to protect 135 00:07:32,880 --> 00:07:36,400 Speaker 2: themselves from a threat and to repair. CDR one involves 136 00:07:36,400 --> 00:07:39,120 Speaker 2: a shift from energy production to oxidative stress in order 137 00:07:39,160 --> 00:07:42,840 Speaker 2: to fight off the invader. CDR two involves tissue proliferation 138 00:07:42,920 --> 00:07:47,200 Speaker 2: for healing. CDR three involves new cell differentiation, connection to 139 00:07:47,240 --> 00:07:51,280 Speaker 2: neighboring cells and re establishes normal cell metabolism and sensitivity 140 00:07:51,320 --> 00:07:55,160 Speaker 2: to outside signals. So how cells get stuck in one 141 00:07:55,160 --> 00:07:57,800 Speaker 2: of the CDR phases. The healthier and more vital a 142 00:07:57,840 --> 00:08:01,040 Speaker 2: person or the tissue is, the more red Injured cells 143 00:08:01,080 --> 00:08:04,200 Speaker 2: can enter and complete the CDR cycle with total resolution. 144 00:08:04,600 --> 00:08:07,640 Speaker 2: But if any cells fail to complete the cycle and reintegrate, 145 00:08:07,680 --> 00:08:10,679 Speaker 2: this might create a weak link susceptibility to later injury. 146 00:08:11,080 --> 00:08:13,920 Speaker 2: I often express this to patients like this, whenever you 147 00:08:13,960 --> 00:08:16,920 Speaker 2: get stressed, whatever your weak link is, that's what breaks. 148 00:08:17,360 --> 00:08:20,480 Speaker 2: On a systemic level. Re Exposure to a toxin your 149 00:08:20,480 --> 00:08:23,160 Speaker 2: body has seen before tends to trigger a faster and 150 00:08:23,200 --> 00:08:25,720 Speaker 2: more extreme response than the first time. I see this 151 00:08:25,800 --> 00:08:29,480 Speaker 2: most often with SERRS chronic inflammatory response syndrome from biotoxins. 152 00:08:30,520 --> 00:08:34,440 Speaker 2: Chronic CDR one activation cells get stuck in CDR one 153 00:08:34,559 --> 00:08:37,800 Speaker 2: due to ongoing inflammation from a real ongoing threat, you're 154 00:08:37,840 --> 00:08:40,319 Speaker 2: still in a toxic environment, or you still have an infection, 155 00:08:40,720 --> 00:08:45,560 Speaker 2: a perceived ongoing threat an MPO myloperoxidase, chronic overactivation fits here, 156 00:08:46,120 --> 00:08:49,679 Speaker 2: or chronic hypersensitivity of the pure energic receptors that first 157 00:08:49,720 --> 00:08:54,760 Speaker 2: responded to the extracellular ATP. Sometimes the oxidative stress involved 158 00:08:54,760 --> 00:08:58,200 Speaker 2: in normal CDR one initiation can actually damage the enzyme 159 00:08:58,280 --> 00:09:01,320 Speaker 2: needed to shut CDR one off. This may happen when 160 00:09:01,360 --> 00:09:04,960 Speaker 2: the CDR gets initiated in an already inflamed environment, such 161 00:09:04,960 --> 00:09:08,559 Speaker 2: as in cardiovascular disease in metabolic syndrome. In these cases, 162 00:09:08,600 --> 00:09:12,559 Speaker 2: the oxidative damage secondary to the metabolic problem might might 163 00:09:12,640 --> 00:09:17,160 Speaker 2: prevent resolution and thus building blocks for membrane repair. Phosphatittolcholine, 164 00:09:17,160 --> 00:09:21,120 Speaker 2: and essential fatty acids might be beneficial. Exercise has been 165 00:09:21,120 --> 00:09:24,160 Speaker 2: shown to help regulate that enzyme that shuts the CDR 166 00:09:24,240 --> 00:09:27,040 Speaker 2: one off, called CD thirty nine, so this can be 167 00:09:27,080 --> 00:09:30,640 Speaker 2: a meaningful intervention at this stage. Quercitin and rezviraitrol also 168 00:09:30,679 --> 00:09:34,000 Speaker 2: help to regulate CD thirty nine, as do T regulatory cells. 169 00:09:34,160 --> 00:09:37,440 Speaker 2: The most relevant supplement that modulates T regulatory cells is 170 00:09:37,600 --> 00:09:41,600 Speaker 2: in this capacity is vitamin D three, A denazine, a 171 00:09:41,600 --> 00:09:45,240 Speaker 2: breakdown product of used ATP that accumulates throughout the day 172 00:09:45,360 --> 00:09:50,760 Speaker 2: also boosts CD thirty nine production. Caffeine notoriously blocks adentozine receptor, 173 00:09:50,840 --> 00:09:52,960 Speaker 2: so if someone is stuck in CDR one and they 174 00:09:53,040 --> 00:09:55,280 Speaker 2: drink a coffee or another caffeine source, it might be 175 00:09:55,320 --> 00:09:57,439 Speaker 2: worth taking a holiday from it for a few weeks 176 00:09:57,640 --> 00:10:00,880 Speaker 2: to clear out the pipes and resensitize the adentizine receptors. 177 00:10:01,320 --> 00:10:05,480 Speaker 2: Already damaged mitochondria can also trigger ongoing oxidative stress, which 178 00:10:05,520 --> 00:10:09,080 Speaker 2: can damage the CD thirty nine enzyme. I suspect selective 179 00:10:09,080 --> 00:10:12,880 Speaker 2: antioxidants that might clean up excessive reactive oxygen species might 180 00:10:12,880 --> 00:10:17,320 Speaker 2: shine here, like molecular hydrogen. Traditional mitochondrial supplements tend to 181 00:10:17,360 --> 00:10:20,520 Speaker 2: favor oxidative phosphorylation, which is inappropriate at this step, and 182 00:10:20,600 --> 00:10:22,680 Speaker 2: a Vogue noted that it can in some cases even 183 00:10:22,679 --> 00:10:26,560 Speaker 2: make things worse, assuming that the original insult is gone. 184 00:10:26,559 --> 00:10:30,120 Speaker 2: Lotos naltrexone can really shine at resetting a chronic stress response, too. 185 00:10:30,760 --> 00:10:34,200 Speaker 2: According to nevaux. Diseases that fit a chronic CDR I 186 00:10:34,320 --> 00:10:39,199 Speaker 2: activation pattern include sers, chronic inflammatory response syndrome, chronic infections 187 00:10:39,200 --> 00:10:43,560 Speaker 2: of all kinds, allergies, and asthma. Chronic CDR two activation. 188 00:10:44,000 --> 00:10:47,240 Speaker 2: The tissue proliferation phase might go awry if mature cells 189 00:10:47,280 --> 00:10:50,360 Speaker 2: attempt to revert back to stem cells but fail, then 190 00:10:50,440 --> 00:10:53,320 Speaker 2: they can become sinescent or zombie cells. A few of 191 00:10:53,360 --> 00:10:56,240 Speaker 2: these can still be beneficial to the overall process, triggering 192 00:10:56,280 --> 00:10:59,920 Speaker 2: inflammatory cytokines that can help to perpetuate healing, but many 193 00:11:00,120 --> 00:11:02,400 Speaker 2: of them can halt the danger response cycle, the cell 194 00:11:02,480 --> 00:11:05,000 Speaker 2: danger response cycle, and it can get stuck here. If 195 00:11:05,000 --> 00:11:07,760 Speaker 2: this is the case, fasting can be helpful to trigger autopogy. 196 00:11:08,640 --> 00:11:12,240 Speaker 2: Warburg metabolism characteristic of CDR two occurs in the presence 197 00:11:12,280 --> 00:11:15,560 Speaker 2: of oxygen that isn't explicitly used for ATP production, and 198 00:11:15,559 --> 00:11:18,240 Speaker 2: this extra oxygen appears to be part of the signaling 199 00:11:18,280 --> 00:11:22,160 Speaker 2: process for tissue remodeling and regeneration, which implies that hyperbaric 200 00:11:22,200 --> 00:11:25,160 Speaker 2: oxygen can be helpful if someone is locked in unresolved 201 00:11:25,160 --> 00:11:29,720 Speaker 2: CDR two. However, as excessive reactive oxygen species characterized CDR 202 00:11:29,800 --> 00:11:33,320 Speaker 2: ie h BOT can potentially be harmful if someone is 203 00:11:33,320 --> 00:11:36,520 Speaker 2: stuck in that phase rather than in CDR two. Because 204 00:11:36,559 --> 00:11:40,040 Speaker 2: Warburg metabolism runs on glucose, someone stuck in this phase 205 00:11:40,120 --> 00:11:42,600 Speaker 2: might do well on the ketogenic diet to switch the 206 00:11:42,640 --> 00:11:47,280 Speaker 2: metabolic fuel from glucose to fat. According to Navou, diseases 207 00:11:47,320 --> 00:11:50,640 Speaker 2: that fit a chronic CDR two activation pattern include metabolic 208 00:11:50,640 --> 00:11:55,400 Speaker 2: disorders like diabetes, hypertension, heart disease, peripheral vascular disease, elevated 209 00:11:55,520 --> 00:11:59,120 Speaker 2: uric acid, fatty liver, and some fibrotic disorders like pulmonary 210 00:11:59,200 --> 00:12:02,160 Speaker 2: fibrosis and key Lloyd's irritable balll disease, crones al sort 211 00:12:02,200 --> 00:12:06,280 Speaker 2: of colitis, and cancers. Of course, chronic CDR three activation, 212 00:12:06,679 --> 00:12:09,680 Speaker 2: the tissue remodeling phase may fail to progress to resolution 213 00:12:09,880 --> 00:12:12,440 Speaker 2: if the we're all done now signal fails. What this 214 00:12:12,520 --> 00:12:15,000 Speaker 2: looks like depends upon what the tissue is supposed to do, 215 00:12:15,080 --> 00:12:17,679 Speaker 2: but ultimately it means the tissue is no longer actively 216 00:12:17,720 --> 00:12:21,000 Speaker 2: inflamed and no longer actively remodeling either. It's just not functional. 217 00:12:21,320 --> 00:12:23,680 Speaker 2: This might occur due to sinescent cells that made it 218 00:12:23,720 --> 00:12:27,520 Speaker 2: through CDR two, but DNA damage renders them nonfunctional. Since 219 00:12:27,559 --> 00:12:30,480 Speaker 2: the parasympathetic nervous system is required to send the all 220 00:12:30,520 --> 00:12:33,680 Speaker 2: clear signal. Treatments that stimulate the vagus nerve are indicated here. 221 00:12:33,760 --> 00:12:37,440 Speaker 2: Even in the absence of overt disautonomic symptoms. Nicotine patches 222 00:12:37,559 --> 00:12:39,920 Speaker 2: might be useful for this population for the same reason, 223 00:12:40,000 --> 00:12:43,600 Speaker 2: though that's speculative. But along these lines, healthy social connections 224 00:12:43,640 --> 00:12:46,480 Speaker 2: and support are huge for sending safety signals to the body. 225 00:12:47,120 --> 00:12:50,880 Speaker 2: Specialized pro resolve and mediators SPMs also fit here. Their 226 00:12:50,920 --> 00:12:53,720 Speaker 2: whole purpose is to clear out the metabolic waste left 227 00:12:53,720 --> 00:12:58,160 Speaker 2: over after a conflict so that resolution can occur. Direct 228 00:12:58,240 --> 00:13:01,160 Speaker 2: mitochondrial support is more likely to be beneficial here too, 229 00:13:01,240 --> 00:13:05,360 Speaker 2: including red light therapy to try to restore normal oxidative phosphorylation. 230 00:13:05,840 --> 00:13:09,120 Speaker 2: According to Nevoes, diseases that fit a chronic CDR three 231 00:13:09,240 --> 00:13:16,160 Speaker 2: activation pattern include neuropsychiatric conditions like autism, OCD, anxiety, depression, bipolar, schizophrenia, 232 00:13:16,520 --> 00:13:21,400 Speaker 2: PANS and pandas, Parkinson's, Alzheimer's, multiple sclerosis, touretts als, and 233 00:13:21,480 --> 00:13:29,800 Speaker 2: traumatic brain injuries. Many autoimmune conditions lupus, scleroderma, chogrins, polymyalgebraumatica, ankylosing, spondylitis, hashimotos, 234 00:13:29,800 --> 00:13:34,800 Speaker 2: and rheumatoid arthritis, chronic pain syndromes like fibromyalgia, alodinia, complex 235 00:13:34,840 --> 00:13:39,960 Speaker 2: regional pain syndrome, eye diseases like macular degeneration presbiopia presbicusis, 236 00:13:40,640 --> 00:13:44,920 Speaker 2: chronic migraines and headaches, thoriasis, exzema, and more so. The 237 00:13:44,920 --> 00:13:49,120 Speaker 2: therapeutic order of naturopathic medicine revisited. Novau makes the point 238 00:13:49,160 --> 00:13:52,960 Speaker 2: that the normal health cycle requires adequate nutrition, nutrient intake, 239 00:13:53,040 --> 00:13:56,800 Speaker 2: waste and toxin removal, restorative sleep, and connections to nature 240 00:13:56,800 --> 00:14:00,439 Speaker 2: and other people. Particularly, CDR IE maps clearly onto the 241 00:14:00,480 --> 00:14:03,760 Speaker 2: first step in the therapeutic order of naturopathic medicine. This 242 00:14:03,800 --> 00:14:05,880 Speaker 2: is what the order is though. Identify and remove the 243 00:14:05,920 --> 00:14:08,959 Speaker 2: obstacle to cure from the environment, give the body the 244 00:14:08,960 --> 00:14:12,040 Speaker 2: building blocks that it needs to heal, stimulate the vital force, 245 00:14:12,440 --> 00:14:16,920 Speaker 2: address and support weaken damage systems, correct structural integrity, address 246 00:14:17,000 --> 00:14:21,720 Speaker 2: pathology with nutriceuticals, address pathology with pharmaceuticals, and last suppressed 247 00:14:21,720 --> 00:14:25,440 Speaker 2: symptoms with pharmaceuticals only when necessary. But that's all big picture. 248 00:14:25,520 --> 00:14:28,320 Speaker 2: The CDR offers a fascinating peak at what might be 249 00:14:28,360 --> 00:14:31,480 Speaker 2: going wrong at the cellular level, depending upon the disease 250 00:14:31,560 --> 00:14:34,240 Speaker 2: process in question. I hope that as more studies are done, 251 00:14:34,280 --> 00:14:37,360 Speaker 2: it'll become increasingly clear how we might help to hit 252 00:14:37,440 --> 00:14:40,720 Speaker 2: a reset button in each case. So there are two 253 00:14:41,600 --> 00:14:44,320 Speaker 2: studies or two articles that this comes from. I'll link 254 00:14:44,360 --> 00:14:47,440 Speaker 2: to both of them in the show notes and thank 255 00:14:47,480 --> 00:14:49,280 Speaker 2: you for joining me and I'll see you next week. 256 00:14:51,240 --> 00:14:54,800 Speaker 1: Thanks for listening to Christian Natural Health. This show is 257 00:14:54,880 --> 00:14:57,680 Speaker 1: run by you, so please write in with topic and 258 00:14:57,840 --> 00:15:02,480 Speaker 1: guest suggestions for future shows. For more great content, subscribe 259 00:15:02,560 --> 00:15:07,960 Speaker 1: to Dr Laurence blog at www dot Doctor Laurendeville dot 260 00:15:08,000 --> 00:15:12,840 Speaker 1: com or follow her on Facebook or Twitter at doctor Laurendeville. 261 00:15:13,120 --> 00:15:15,480 Speaker 1: If you enjoyed the show, don't forget to share it 262 00:15:15,520 --> 00:15:18,200 Speaker 1: with your friends and give us a five star rating 263 00:15:18,320 --> 00:15:21,440 Speaker 1: in iTunes. It really helps us to stand out so 264 00:15:21,600 --> 00:15:24,800 Speaker 1: other people can discover great content as well. Have a 265 00:15:24,840 --> 00:15:26,560 Speaker 1: great week and God bless you.