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Speaker 1: You're listening to a Muma Mia podcast. Mumma Mea acknowledges

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Speaker 1: the traditional owners of land and waters that this podcast

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Speaker 1: is recorded on.

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Speaker 2: Hi.

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Speaker 1: I'm Claire Murphy. This is Muma MIA's daily news podcast,

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Speaker 1: The Quikie. The Quikie's first investigation into the rising popularity

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Speaker 1: of weight loss drugs was back in February twenty twenty.

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Speaker 3: Three, semaglutide, for reasons we really don't understand particularly well,

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Speaker 3: is especially good at causing weight loss, whereas other gopu

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Speaker 3: one analogs have the same effect on diabetes but without

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Speaker 3: quite as much weight loss.

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Speaker 1: Eighteen months later, what have we learned? It seems like

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Speaker 1: everyone's been waiting for the other shoe to drop on

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Speaker 1: these drugs, that something will expose them as having terrible

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Speaker 1: long term issues. But has that eventuated? Before we find

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Speaker 1: out what we now know about weight loss drugs, including

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Speaker 1: when and if they might be switched to on label

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Speaker 1: use for those who don't suffer from type two diabetes,

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Speaker 1: let's check in with the Quickie newsroom. Wednesday, July thirty one,

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Speaker 1: Rex Airlines has announced they've gone into voluntary administration, canceling

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Speaker 1: all flights between major airports regional SAB three forty flights

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Speaker 1: will continue to operate, but domestic seven three seven services

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Speaker 1: have been halted, with Virgin Australia offering to help affected

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Speaker 1: REX passengers with free rebooking. The two airlines are also

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Speaker 1: discussing if Virgin can support regional customers moving forward through

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Speaker 1: codeshare or interline arrangements, and making Virgin's frequent Flyer benefits

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Speaker 1: available to Rex's regional customers. Virgin has also offered support

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Speaker 1: to employees of the embattled airlines, saying they could apply

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Speaker 1: for any open positions. The number of Ossie kids finishing

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Speaker 1: high school has dropped over the last seven years, the

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Speaker 1: federal government planning more support in an attempt to stem

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Speaker 1: the dropout rate. The number of Australian children completing year

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Speaker 1: twelve has gone from eighty five percent to seventy nine.

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Speaker 1: That number higher for public schools, decreasing from eighty three

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Speaker 1: percent to seventy three point six. Education Minister Jason Claire

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Speaker 1: says over the next ten years they'll introduce funding called

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Speaker 1: Better and Fairer Schools, investing billions to make a difference

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Speaker 1: to those who really need it. The new targets will

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Speaker 1: be introduced to increase the number of students finishing year

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Speaker 1: twelve to eighty three point eight percent by twenty thirty,

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Speaker 1: with a focus on students from regional and rural areas

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Speaker 1: and those from low socioeconomic backgrounds, while initiatives will be

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Speaker 1: introduced to attract and retain teachers and Israeli strike has

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Speaker 1: targeted a senior HESBELA commander in Lebanon's capital Beirut, in

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Speaker 1: retaliation for a rocket attack that killed twelve children three

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Speaker 1: days earlier. A Hesbela official said the strike caused damage

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Speaker 1: to buildings, but the fate of the intended target was unclear.

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Speaker 1: People in Beirut have been on edge for days after

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Speaker 1: the attack on the Israeli occupied Golan Heights on Saturday,

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Speaker 1: which killed twelve young Israelis playing football. Hesbela has denied

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Speaker 1: being behind the strike. Hesbla and Israel, who last went

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Speaker 1: to war with each other in two thousand and six,

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Speaker 1: have been trading fire since the eruption of the war

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Speaker 1: in Gaza, the US Defense Secretary saying he doesn't believe

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Speaker 1: war is inevitable between them at this stage. Taylor Swift

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Speaker 1: has spoken out after a shocking knife attack at a

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Speaker 1: UK kids dance and yoga event inspired by her and

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Speaker 1: her music. Swift posted on social media saying the horror

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Speaker 1: of yesterday's attack at Southport is washing over me continuously

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Speaker 1: and I'm just completely in shock the loss of life

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Speaker 1: and innocence and the horrendous trauma inflicted on everyone who

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Speaker 1: was there, the families and first responders. She goes on

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Speaker 1: to say, these were just little kids at a dance class.

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Speaker 1: I'm at a complete loss for how to ever convey

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Speaker 1: my sympathies to these families. Three children have now died

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Speaker 1: in what was one of the worst assaults against children

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Speaker 1: the UK has seen in decades. A seventeen year old

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Speaker 1: boy was arrested on suspicion of murder and attempted murder.

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Speaker 1: The motive for the attack is still unknown.

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Speaker 2: The pulse on Paris thanks to move by Mamma Mia

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Speaker 2: the exercise app he'll actually.

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Speaker 1: Enjoy in Paris. Kaylee McEwan has defended her one hundred

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Speaker 1: meter backstroke title, breaking an Olympic record as she stormed

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Speaker 1: home from fourth place after the first fifty to take

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Speaker 1: gold in the pool in her return to the Olympics

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Speaker 1: since having to pull out in Tokyo. Legendary gymnast Simone

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Speaker 1: Biles has added another gold to her collection, the US

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Speaker 1: winning the women's team final. It was heartbreak for the

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Speaker 1: women's Aussie rugby sevens team, missing out on a medal

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Speaker 1: after the US scored a try at full time to

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Speaker 1: take the bronze medal match fourteen to twelve. The Boomers

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Speaker 1: also lost their game against Canada ninety three to eighty three,

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Speaker 1: but the Ossie men's water a polo team stunned two

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Speaker 1: time defending champions Serbia, downing them eight to three. That's

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Speaker 1: what's happening in the world today. Next, are we far

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Speaker 1: enough down the track to better understand the long term

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Speaker 1: impacts of using the current crop of weight loss drugs.

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Speaker 1: Last month, Oprah Winfrey's good friend Gail King shared on

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Speaker 1: her CBS Morning show that was unwell.

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Speaker 2: You said, I'm going to rally. I'm going to rally.

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Speaker 3: She had some kind of stomach flue where stuff was

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Speaker 3: coming out of both ends.

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Speaker 4: I won't get too graphic, but needless to.

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Speaker 3: Say, she ended up in the hospital dehydration formar to ivy,

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Speaker 3: so it.

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Speaker 2: Was a very serious.

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Speaker 1: Immediately, the headlines linked her condition to her use of

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Speaker 1: the weight loss drug or zempic, which is labeled for

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Speaker 1: use only by those suffering from type two diabetes here

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Speaker 1: in Australia. The comments sections were lit up with people

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Speaker 1: thinking this was the news they'd all been waiting for.

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Speaker 1: Oprah reportedly in hospital over stomach issues. People need to

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Speaker 1: be aware how dangerous a zembi k is.

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Speaker 2: Oprah got o zepic stomach That's why she's in the hospital.

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Speaker 1: But that wasn't what happened. Oprah explained that she was

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Speaker 1: suffering from a stomach bug that had caused severe dehydration.

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Speaker 1: She went on to say that five others in her

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Speaker 1: household had also caught it, advising people to wash their

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Speaker 1: hands because her doctor had told her that virus can

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Speaker 1: stay on some common surfaces for up to ten hours.

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Speaker 1: But the quick jump to the ozepic must be the issue.

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Speaker 1: Response is not a new phenomen There are many commentators

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Speaker 1: who are publicly saying that we're all waiting for these

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Speaker 1: weight loss drugs to show their true face. New York

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Speaker 1: Times best selling author Calli Means recently posted a link

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Speaker 1: to a CNN story that claimed poison centers in the

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Speaker 1: US have seen a fifteen hundred percent increase in calls

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Speaker 1: relating to weight loss drug injections as people accidentally overdose.

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Speaker 1: He wrote, the doctors are telling people that weekly injections

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Speaker 1: of this poison is a miracle cure for obesity. In

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Speaker 1: the article, it explains that most of these cases in

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Speaker 1: which they experienced side effects like severe nausea, vomiting and

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Speaker 1: stomach pain, resolved quickly after being treated with fluids and

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Speaker 1: anti nausea medication. It also explained that the sharp increase

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Speaker 1: in reports coincided with a large surge in doctors prescribing

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Speaker 1: the drugs. There have been three debts in Australia which

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Speaker 1: are being investigated for their links to the use of

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Speaker 1: semaglutide products. There's also a lawsuit currently UNDERWEG in the

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Speaker 1: US where the plaintiff's alleged their use of weight loss

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Speaker 1: injections has caused severe gastro and tearesnal issues and can

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Speaker 1: cause dangerous conditions like pancreatitis and gastroparesis, where the nerves

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Speaker 1: and muscles in the stomach weaken. They claim the companies

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Speaker 1: who make these drugs are downplaying the side effects. But

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Speaker 1: then there are also other headlines that are claiming the

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Speaker 1: huge increase in semic glutide use amongst both diabetes sufferers

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Speaker 1: and those using it off label to lose weight has

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Speaker 1: shown other positive outcomes.

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Speaker 2: Ozembic may reduce risk of dementia and nicotine dependence. Ozembic

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Speaker 2: boost fertility drugs like ozembig could lower cancer risks.

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Speaker 1: We've already looked into the impact of semic glutide on

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Speaker 1: fertility with Boston based physician doctor Kevin Gendro, who has

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Speaker 1: a patient who's fifty three and pregnant with twins.

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Speaker 4: I have actually lost track of the number of patients

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Speaker 4: in their late forties and early fifties who are now

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Speaker 4: pregnant on these medications. And by the way, I should

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Speaker 4: just say that it is advised from the manufacturers like Eli,

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Speaker 4: Lilly and Novnortis that you stop taking these medications at

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Speaker 4: least two months before pregnancy. So these really are accidental pregnancies.

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Speaker 1: So where are we at In July twenty twenty four

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Speaker 1: in the weight loss injection debate. Doctor Brad MacKaye is

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Speaker 1: a GP author, podcast host, and medical commentator. Right at

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Speaker 1: the end of last year, there were so many predictions

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Speaker 1: that there'll be some major discovery about weight loss drugs,

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Speaker 1: some negative impact that long term use would have Have

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Speaker 1: we seen anything like that eventuate, or are we just

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Speaker 1: maybe not understanding that these drugs have actually been around

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Speaker 1: for quite some time. They just got really popular last year.

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Speaker 2: Well, it depends on what you mean by long term.

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Speaker 2: So we've only had the drugs available for use in

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Speaker 2: the last sort of five or so years, less than

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Speaker 2: that in Australia, and so if that's long term, we're

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Speaker 2: not seeing major problems from using it. But yeah, we

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Speaker 2: really don't know what the longer term outcomes if we

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Speaker 2: were talking about twenty or thirty years of being on

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Speaker 2: the drugs. Initially there were warnings that everyone could go

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Speaker 2: at thyroid cancer by using the drugs. That has been

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Speaker 2: seen in rats, but yeah, really not seen in humans yet.

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Speaker 1: I guess the big one that we were warned about,

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Speaker 1: and there is currently a lawsuit happening in the US

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Speaker 1: about this, and that is gastro intestinal issues, obstructions and

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Speaker 1: something called gastro poresis and pancreatitis. I guess that's the

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Speaker 1: one major side effect we are still seeing with the

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Speaker 1: use of these weight loss drugs.

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Speaker 2: Yeah, so with any drug, you're going to be having

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Speaker 2: some side effects. Fortunately, a lot of these side effects

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Speaker 2: are really rare, so pancreatitis, Yeah, we need to be

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Speaker 2: mindful of this. Certainly, this happens in very few people.

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Speaker 2: The benefits of taking the medication off and outweigh the

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Speaker 2: small number of side effects. Everything's a balanced between risks

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Speaker 2: and benefits. But yeah, certainly people need to know about pancreatitis.

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Speaker 2: And if they're getting like a pain just over their

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Speaker 2: stomach region at the top of their abdomen and sometimes

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Speaker 2: it goes through to their back, then you need to

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Speaker 2: be thinking about grewtitis and talking to your doctor about

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Speaker 2: it and having a blood test or a scan to

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Speaker 2: figure out if that's the case or not. So we

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Speaker 2: can work that out if we know that people are

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Speaker 2: on these medications. The other things about having like an

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Speaker 2: eelias or a bow that's not working properly, It's very

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Speaker 2: common for you able to feel constipation. I've had a

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Speaker 2: few patients with diarrhea as well, so the other extreme

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Speaker 2: and yeah, like an ilias where your bowet just isn't

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Speaker 2: pumping your food through properly and everything goes to a standstill.

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Speaker 2: But yeah, if people aren't pulling and if they aren't

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Speaker 2: farting for a few days on end, you've got to

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Speaker 2: be sorting things out, chatting with your doctor about it

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Speaker 2: pretty promptly.

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Speaker 1: You're seeing the benefits outweigh the side effects in a

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Speaker 1: lot of these cases. But I think we're seeing a

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Speaker 1: list of increasing benefits that the use of semaglue tide

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Speaker 1: might have, And I'll just run through a few of

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Speaker 1: them here. We've got a decrease risk of thirteen obesity

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Speaker 1: associated cancers. It helps with addiction to things like nicotine

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Speaker 1: and alcohol, anxiety, Parkinson's disease, fatty livid disease, it helps

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Speaker 1: with fertility, may help with the symptoms of rheumatoid arthritis.

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Speaker 1: I know that they've already allowed some of these drugs

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Speaker 1: to claim that they help with cardiovascular disease. There's kidney disease. Like,

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Speaker 1: are we surprised that the list of things that weight

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Speaker 1: loss drugs, or semaglutide in particular helps with is increasing

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Speaker 1: because we understand the relationship between obesity and health issues.

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Speaker 2: Yeah, so it's a really complex issue. First of all. Yeah,

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Speaker 2: like there's the drug and how that acts on your body,

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Speaker 2: but then there's also the effect of decreasing weight, and

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Speaker 2: so we know that there is a whole range of

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Speaker 2: different problems that occur from being overweight. There's lots more

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Speaker 2: inflammation in people's body. We know that it makes osterearthritis worse,

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Speaker 2: we know that it makes cardiovascular disease worse. So anything

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Speaker 2: that's really decreasing the weight, we're just going to be

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Speaker 2: careful that we're not of saying, oh, well, this drug

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Speaker 2: is really really good for all of these things, when

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Speaker 2: it's really the magic is in decreasing the weight, getting

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Speaker 2: rid of the fat cells, getting rid of the inflammation.

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Speaker 2: That's really where a lot of that list is falling.

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Speaker 1: The one that does stand out though, is the use

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Speaker 1: of semaglue tide and addiction. We've seen some research that

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Speaker 1: shows that it does actually impact those receptors in the

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Speaker 1: brain perhaps that deal with addiction, and people have been

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Speaker 1: able to stop smoking, stop drinking. Have we found out

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Speaker 1: a little bit more about what is actually happening there.

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Speaker 2: Yeah, So it seems to be affecting the craving center.

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Speaker 2: So I've had a number of patients who have been

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Speaker 2: emotionally eating, particularly in the evening when they're getting home

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Speaker 2: from work a stressful day. They will often reach for

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Speaker 2: a big tub of ice cream, and so it's not

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Speaker 2: that they're finding that the medication is just decreasing their

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Speaker 2: need for food. It's decreasing them having the munchies. I've

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Speaker 2: had some patients who have even given up smoking. There's

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Speaker 2: some discussion about decreasing the use of cannabis as well.

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Speaker 2: We're kind of thinking that this is really based on

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Speaker 2: affecting our craving center and our desire and need to

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Speaker 2: sustain ourselves in different ways, not just food, enabling our

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Speaker 2: brain to sort of like uncouple a few of these

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Speaker 2: addictions that people have.

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Speaker 1: The other big factor when we're dealing with these drugs

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Speaker 1: is the fact that no one can get their hands

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Speaker 1: on them with any kind of regular ability because of

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Speaker 1: shortages coming from the people who actually make these as

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Speaker 1: two main ones, one in Europe and one in the US.

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Speaker 1: The shortages are they going to continue? You think, do

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Speaker 1: we know whether there is any relief for Australians who've

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Speaker 1: been trying to access these drugs and why this is continuing.

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Speaker 2: A certainly some maglatiders propping up the Danish economy as

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Speaker 2: one of the biggest drivers of the country, making lots

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Speaker 2: and lots of money. At the moment, we're seeing a

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Speaker 2: lot of somemglatiders sort of being taken up in America

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Speaker 2: and Australia, sort of like down the chain as the

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Speaker 2: drugs get distributed around the world. So suddenly we've gone

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Speaker 2: through periods in Australia where the medication has been really scarce,

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Speaker 2: and then it's available at every pharmacy, and then it's

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Speaker 2: scarce again. And so I need to be talking with

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Speaker 2: my patients about that and putting a strategy in place

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Speaker 2: for if they don't have access to the medication that's

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Speaker 2: been working well for them. So I'm hopeful that towards

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Speaker 2: the end of twenty twenty four that we should have

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Speaker 2: more of a steady supply of the medication. But who knows.

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Speaker 2: We really don't know. I think a lot of people

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Speaker 2: are waiting for other drugs to become more available as well,

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Speaker 2: so similar medications and also to become a little bit

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Speaker 2: cheaper over time as well.

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Speaker 1: What about changes to label use, Brad, Because we know

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Speaker 1: that some of these drugs are available for weight loss

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Speaker 1: and others are for those who are suffering with type

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Speaker 1: two diabetes only do you think some of those are

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Speaker 1: going to change anytime soon?

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Speaker 2: So at the moment in Australia. Yeah, simagnetide and the

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Speaker 2: form of o zampa is indicated for diabetes management, so

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Speaker 2: people have been using it off label for weight loss.

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Speaker 2: So that's commonly in the media. So as we find

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Speaker 2: out more things that the drug can be helpful for,

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Speaker 2: the drug company is very happy to add that to

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Speaker 2: the list of lovely things that their drug does for people.

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Speaker 2: But even if we're going back to the start, there

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Speaker 2: were certain hurdles that were put in place for snagulatide.

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Speaker 2: So other medications had actually caused problems, so weight loss

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Speaker 2: drugs had been causing problems and causing heart disease. We

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Speaker 2: had very high hurdles for the drug to get over.

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Speaker 2: So not only did it have to be beneficial for diabetes,

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Speaker 2: but they had to do further studies as well to

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Speaker 2: make sure that people weren't dying from heart disease caused

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Speaker 2: by the drugs. And so fortunately, yeah, even those early

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Speaker 2: stages of research, we found that the drug was not

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Speaker 2: causing more heart attacks, and even some of the data

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Speaker 2: was coming back saying that it was going to be

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Speaker 2: maybe a little bit more beneficial protecting people from heart disease.

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Speaker 2: So yeah, that's not unexpected at this point in time.

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Speaker 1: Do you think this narrative about waiting for the other

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Speaker 1: shoe to drop for weight loss drugs on long term

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Speaker 1: health is because it seems too good to be true.

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Speaker 1: We were told for so long that a drug would

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Speaker 1: and it would help people lose weight and we would

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Speaker 1: all be happy and live fairy tale lives from that

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Speaker 1: point on, and it seems like that has actually arrived

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Speaker 1: a week. Just so cynical now about drug companies and

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Speaker 1: about potential cover ups of things that might be happening

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Speaker 1: to people in using these drugs that we can't believe

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Speaker 1: that semaglutide is doing what semaglutide claims to do.

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Speaker 2: I think it's different for everybody, so I think some

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Speaker 2: people get amazing benefits. I have some patients who are

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Speaker 2: using it for their diabetic treatment, and yeah, certainly they

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Speaker 2: would be dead already if it wasn't for these drugs.

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Speaker 2: They've been amazing at keeping their blood sugar under control

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Speaker 2: when nothing else has fricking worked. But then other people

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Speaker 2: like they do have awful side effects from it as well.

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Speaker 2: As I've had many patients who have tried very small

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Speaker 2: doses of it and they just haven't been able to

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Speaker 2: tolerate it. They've been nauseated all the time, they've been

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Speaker 2: vomiting multiple times over the day. It's just been awful

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Speaker 2: for them. And so for those people, they're really disappointed.

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Speaker 2: I think it's not really a panacea. I think there's

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Speaker 2: also a lot of hard work that needs to be

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Speaker 2: done by people to lose weight. And the other issue

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Speaker 2: as well is that we're finding that some people, when

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Speaker 2: they're losing lots of weight from using these drugs, they're

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Speaker 2: also losing a lot of muscle mass as well. Some

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Speaker 2: people can end up looking quite gaunt or skeletal, so

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Speaker 2: going to the gym and putting on that extra muscle

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Speaker 2: mass can be really helpful. And then we're even starting

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Speaker 2: to see sort of like a weird like Sneaches situation

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Speaker 2: from doctor SEUs where people are now starting to use

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Speaker 2: different treatments, so cosmetic treatments to plump up the muscles

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Speaker 2: in their face, so using sort of like a magnetic

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Speaker 2: equipment to stimulate their muscle fibers so they can lose

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Speaker 2: weight but then still maintain the muscle as they're going

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Speaker 2: through their process of weight loss. It's a money making

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Speaker 2: industry in many different ways.

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Speaker 1: Now everyone goes and googles sneaches from doctor Zoos to

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Speaker 1: try and figure out what that reference means. One thing

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Speaker 1: that people have encountered after using weight loss drugs is

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Speaker 1: something it's being referred to as ozenpic face. Celebrities like

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Speaker 1: Robbie Williams, Scott Dissey and Sharon Osbourne have been debuting

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Speaker 1: their recent dramatic weight loss with faces looking more hollowed

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Speaker 1: out and gaunt. As famous French actress Catherine de Nerve

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Speaker 1: once said, at a certain age, you have to choose

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Speaker 1: between your face and your ass, meaning if you want

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Speaker 1: to be thinner, you can expect your face to look

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Speaker 1: more aged, but if you carry a little more weight,

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Speaker 1: it will act like a filler and pad those wrinkles out.

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Speaker 1: The experts agree, explain that facial fat pads in those

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Speaker 1: losing weight rapidly are also losing volume fast, and because

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Speaker 1: the skin is not as elastic as at once was,

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Speaker 1: it starts to sag in the places where those fat

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Speaker 1: pads used to be full. The expert's advice is, if

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Speaker 1: you need to lose weight for health reasons, try to

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Speaker 1: do it slower so the choice between face and us

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Speaker 1: isn't quite so dramatic. Thanks for tuning in today, friends,

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Speaker 1: taking some time to feed your mind. You can read

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Speaker 1: more about ozebic Face on our website, written by our

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Speaker 1: beauty editor and co host of our U Beauty podcast,

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Speaker 1: Aaron Dockerty. The link is in our show notes, and

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Speaker 1: if there's a new story you'd like us to investigate

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Speaker 1: in further detail, reach out via email the quiki at

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Speaker 1: mammamea dot com dot au, or find us on threads, Instagram,

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Speaker 1: and Facebook. The Quikie is produced by me Claire Murphy

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Speaker 1: and our senior producer Taylor Strano, with audio production by

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Speaker 1: Tomlin