WEBVTT - Eat More. Sleep Colder. Lift Heavier.

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<v Speaker 1>You're listening to a Mama Mia podcast. Mamma mea acknowledges

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<v Speaker 1>the traditional owners of land and waters that this podcast

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<v Speaker 1>is recorded on. Eat more protein. How about some salmon

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<v Speaker 1>with that egg? How about some cottage cheese with that steak?

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<v Speaker 1>How about you sprinkle some creatine all over that thing?

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<v Speaker 1>What about protein powder and your protein powder for a

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<v Speaker 1>morning smoothie full of fiber? And while we're at it,

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<v Speaker 1>how many supplements? There's too many supplements? Should I, in

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<v Speaker 1>fact rattle when I walk? Speaking of walking? Is walking enough?

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<v Speaker 1>Counting my steps? Is that just propaganda? Now? And if

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<v Speaker 1>I manage to get to the gym, what should I

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<v Speaker 1>do there? For decades it's been burned, baby burn, and

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<v Speaker 1>now it's lift, baby lift. Does it feel suddenly like

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<v Speaker 1>there's a set of new rules that no one sent

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<v Speaker 1>you that you just get glimpses of them yelled at

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<v Speaker 1>you through your phone? One hundred grams of protein, bitch

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<v Speaker 1>as you scroll past a twenty eight year old with

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<v Speaker 1>fluoro athlesia and a neutrib bullet. Well, you'd be right.

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<v Speaker 1>The rules are new because the old rules they were

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<v Speaker 1>written for men, sweat, sprint, starve, And they were also

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<v Speaker 1>written by the toxic body culture we were so surrounded

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<v Speaker 1>by as we came of age. It was invisible to

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<v Speaker 1>the naked eye, size zero, low rise genes, thigh gaps,

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<v Speaker 1>crash diets, and the endless comparison game. Now we've woken

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<v Speaker 1>up in what feels like a second puberty, and we've

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<v Speaker 1>only just barely started to understand our bodies. They can

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<v Speaker 1>feel like angry strangers. Hormones are fluctuating, sleep is elusive.

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<v Speaker 1>Joints ache for no reason, and we're told it's just

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<v Speaker 1>the beginning. What wants work doesn't work anymore. What once

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<v Speaker 1>felt intuitive now feels like guesswork. The new rules are

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<v Speaker 1>kinder but also confusing. Move your body more, but don't

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<v Speaker 1>overdo it. Eat red meat, but not too much, because

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<v Speaker 1>your heart gets some sun for vitamin D, but also

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<v Speaker 1>that face from those raisor rays. Sleep more, meditate, fix

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<v Speaker 1>your nervous system, add magnesium, track your cycle. Cut out

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<v Speaker 1>sugar but not fruit or is it fruit too? If

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<v Speaker 1>we decode it. If we find the new rules and

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<v Speaker 1>write them down, learn to live by them, can we

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<v Speaker 1>change what's coming? Protect our minds and our bodies from age,

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<v Speaker 1>from wrinkles and falls, forgetfulness, aches and pains and the

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<v Speaker 1>soft stand up grunt? Can eggs really do all that? Hello,

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<v Speaker 1>I'm Holly Wainwright and I am Mid, Midlife, Midfamily, mid

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<v Speaker 1>lifting my tiny pink weights. Does it feel like you

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<v Speaker 1>hit a certain birthday with a zero and everyone starts

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<v Speaker 1>yelling at you about protein and dumbbells. Well, if it

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<v Speaker 1>feels like that, you're right, because that's what happens. And

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<v Speaker 1>for this last episode of Mid for season five, we

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<v Speaker 1>wanted to ask someone smart to tell us exactly why

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<v Speaker 1>that is, And so we found called Louisa Nicola and

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<v Speaker 1>asked her what she thought of all the things midwomen

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<v Speaker 1>are told to do. Why Louisa, Well, because she is

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<v Speaker 1>an Australian neurophysiologist and human performance coach who's living in

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<v Speaker 1>the US and working there at the moment, right at

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<v Speaker 1>the forefront of all the science about longevity and health

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<v Speaker 1>and performance and exercise and food. She used to be

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<v Speaker 1>a world championship triathlete, representing Australia at all kinds of

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<v Speaker 1>major international events before a serious injury stopped her athletic

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<v Speaker 1>career in its tracks. But that also set her on

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<v Speaker 1>the path to understand what she calls brain training and

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<v Speaker 1>become an expert in basically telling us normies what athletes

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<v Speaker 1>and high performance people know to be true. One of

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<v Speaker 1>the things we're going to talk to Louisa about today

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<v Speaker 1>is how to care for our brains as we age.

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<v Speaker 1>But we are going to talk to her two about

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<v Speaker 1>our bodies because that is one of the things that

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<v Speaker 1>everybody's always talking to us about. What are the things

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<v Speaker 1>to prioritize to live better longer? To be honest, the

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<v Speaker 1>priorities she told me were a serious surprise. So here

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<v Speaker 1>we go. This is your Nobs guide to the new

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<v Speaker 1>rules of a better life. But before we get started,

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<v Speaker 1>I need to make this clear. The information discussed in

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<v Speaker 1>this episode is not intended to replace professional medical advice.

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<v Speaker 1>Supplement availability, safety, and regulation vary between countries, including Australia.

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<v Speaker 1>You always need to seek guidance from your GP or

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<v Speaker 1>a pharmacist and ensure that any therapeutic goods are listed

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<v Speaker 1>on the Australian Register of Therapeutic Goods before you go

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<v Speaker 1>near them. And if you listen to this conversation and

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<v Speaker 1>you wonder, oh, I thought you might mention this supplement

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<v Speaker 1>or this supplement, because I see them everywhere, there is

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<v Speaker 1>a good reason why not, and that is because here

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<v Speaker 1>in Australia we're actually pretty lucky that our regulations are

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<v Speaker 1>really tight about what you can and can't talk about

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<v Speaker 1>and promote. So if there are a few gaps here,

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<v Speaker 1>that's why. But I still think you are going to

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<v Speaker 1>find this conversation with Louisa Nicola really really interesting. Protein, sleep, exercise.

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<v Speaker 1>Oh my, Louisa, I'm just so happy to be talking

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<v Speaker 1>to you today because as a woman of my age,

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<v Speaker 1>I'm kind of completely overwhelmed by all the stuff I'm

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<v Speaker 1>being told to do and knowing what's real, what's helpful,

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<v Speaker 1>what's not. And then if i am, I know a

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<v Speaker 1>lot of other women are right, and I'd like to

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<v Speaker 1>start with a big gun. So if there's one thing

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<v Speaker 1>we can advise a woman who's in her kind of

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<v Speaker 1>let's say she's in her forties, that her relationship with

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<v Speaker 1>fitness is pretty typical, which is that maybe she goes

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<v Speaker 1>and fits and starts. She might stick to a gym

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<v Speaker 1>regime for a while and then drop out of it.

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<v Speaker 1>She's had times in her life when she's been fitter

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<v Speaker 1>and times in a life where she's been less. So

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<v Speaker 1>what is the one thing we can advise this woman

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<v Speaker 1>to do to change the quality of the next twenty

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<v Speaker 1>years or so, what would it be.

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<v Speaker 2>Well, first of all, Holly, thank you for how you're

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<v Speaker 2>definitely tapping on something that is becoming quite an epidemic.

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<v Speaker 2>We all are inevitably going to face the decline of

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<v Speaker 2>estrogen and progesterone somewhere throughout our life. I think what's

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<v Speaker 2>happening now is menopause is really at the spotlight. It

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<v Speaker 2>is gaining a lot of traction. And this is really

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<v Speaker 2>due to the fact that we had a lot of

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<v Speaker 2>misinformation around menopause and estrogen, etc. And this is now

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<v Speaker 2>causing a lot of women in midlife and even at

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<v Speaker 2>the age of forty to start rethinking their decisions. So

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<v Speaker 2>to cut a long story shot, because I know we're

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<v Speaker 2>going to evolve throughout this conversation, and to answer your question,

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<v Speaker 2>what can a woman do right now to improve the

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<v Speaker 2>next twenty years of her life? Well, look, she can

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<v Speaker 2>do many things, Okay, but let's talk about what actually

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<v Speaker 2>happens at this stage of life in the fourth decade. Well,

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<v Speaker 2>the transition into many menopause comes at around a decade

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<v Speaker 2>prior to the menopause onset. So if we're thinking it

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<v Speaker 2>around the average age, maybe forty two forty three is

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<v Speaker 2>the onset of perimenopause. When we start to see the

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<v Speaker 2>decline of estrogen and progesterome, we need to start thinking

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<v Speaker 2>about what is actually happening, because in my opinion, menopause

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<v Speaker 2>doesn't just happen to your ovaries. It's a neuroendocrine malfunction. Really,

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<v Speaker 2>we have a lot of things that happen to our

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<v Speaker 2>brain and as a result of that, we then go

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<v Speaker 2>through a cascade of issues ranging from bone mineral density.

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<v Speaker 2>We see a decline in that, we see a decline

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<v Speaker 2>in bone mass, in strength, in muscle mass, in cognitive functions,

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<v Speaker 2>and these are the things we need throughout our lifespan,

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<v Speaker 2>throughout my work and through what I do for a

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<v Speaker 2>living and what I research, which is Alzheimer's disease. What

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<v Speaker 2>I can safely say is the one thing you should

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<v Speaker 2>do right now in your forties is practice good exercise.

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<v Speaker 2>You mentioned people. You know some women go through stages

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<v Speaker 2>of they're really motivated, they go to the gym for

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<v Speaker 2>a week, and maybe they go off the gym. And

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<v Speaker 2>what we know is that consistency is key, right because

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<v Speaker 2>if we're going to build a good foundation for our

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<v Speaker 2>body when we're eighty and when we're ninety, even in

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<v Speaker 2>in your sixties and seventies. Really it's got to be

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<v Speaker 2>consistent effort, consistently going to the gym, consistently putting in work,

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<v Speaker 2>and if you have to follow a structured program from

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<v Speaker 2>a personal trainer, I think that's actually becoming more of

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<v Speaker 2>a need these days just to really get the foundation set.

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<v Speaker 1>So what we keep being told right now is to

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<v Speaker 1>forget the hardcore cardio that we might have been doing

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<v Speaker 1>to chase a dress size in our twenties and focus

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<v Speaker 1>on weights. Is it that simple and is that the

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<v Speaker 1>shift we should definitely make.

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<v Speaker 2>It's not that simple, But let me tell you there

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<v Speaker 2>is a need for everything, every part of exercise. When

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<v Speaker 2>we are looking into the scientific literature, we're usually separating

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<v Speaker 2>exercises into three buckets. Right, We've got strength training, We've

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<v Speaker 2>got cardiovascular training, which is your zone too easy, long

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<v Speaker 2>long runs, long swim sessions, et cetera, cardio if you will,

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<v Speaker 2>and then we've got this high intensity training. Right, So

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<v Speaker 2>if we look at across the board, what is going

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<v Speaker 2>to give you the biggest bang for your buck it

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<v Speaker 2>would be strength and that's because we lose strength and

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<v Speaker 2>muscle mass at a very rapid rate. It comes on

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<v Speaker 2>in the fourth decade, right, and we females need more

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<v Speaker 2>strength if we had to, we still need to work

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<v Speaker 2>on our cardiovascular fitness. Right. When we're looking at cardiovascular fitness,

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<v Speaker 2>we're also taking into account that we're training the powerhouses

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<v Speaker 2>of ourselves, which is called the mitochondria. We've got more

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<v Speaker 2>mitochondria than men. So a lot of this marketing what

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<v Speaker 2>you're seeing when you're talking about zone two training, which

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<v Speaker 2>is dubbed out you should be doing cardio at least

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<v Speaker 2>three hours a week. That's really looking at males. Women

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<v Speaker 2>should actually be prioritizing strength. And when I say strength,

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<v Speaker 2>I'm talking about weights, so resistance training and then high

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<v Speaker 2>intensity training. That's like when you're going hard out, not

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<v Speaker 2>hit training, but high intensity, hard out efforts, and then cardio.

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<v Speaker 1>I've heard you rail against the little pink weights we all.

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<v Speaker 2>Have, Yes, it's you want I try and say women

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<v Speaker 2>should move away from the pink weights because listen, it's

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<v Speaker 2>not doing you anything. You're actually wasting your time if

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<v Speaker 2>you're at the gym lifting small lightweights. If we want

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<v Speaker 2>to prevent sycopenia, which is age related muscle loss. If

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<v Speaker 2>we want to enhance our metabolic rate and glucose metabolism,

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<v Speaker 2>we need to without being too scientific, but we need

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<v Speaker 2>to trigger mechano receptors in muscle fibers, right, and that

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<v Speaker 2>is triggered when we lift heavy. To improve our muscle

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<v Speaker 2>mouse increase our muscle musk, we have to lift heavy.

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<v Speaker 2>You're not going to get anything from lifting these two

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<v Speaker 2>kilo dumbbells, which are often painted pink.

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<v Speaker 1>Okay, let's get a bit more serious. I think we'll

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<v Speaker 1>come back to exercise in a while. So women in

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<v Speaker 1>my age, apparently we cannot eat enough protein. It's just protein,

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<v Speaker 1>protein protein. You can't buy cottage cheese anywhere in the

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<v Speaker 1>shops at the moment because the older women have eaten

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<v Speaker 1>it all. Eat eggs, fish, meat, eggs and fish more

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<v Speaker 1>and more. I wonder if what we're being told is right.

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<v Speaker 2>Look, I actually thought it was and I still do.

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<v Speaker 2>I think that bare minimum, every single individual, but mainly women,

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<v Speaker 2>should be having at minimum one hundred grams of protein

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<v Speaker 2>a day. In it it varies right, because we should

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<v Speaker 2>be eating around one point six to one point eight

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<v Speaker 2>grams perk of body weight. So you know, if you're

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<v Speaker 2>seventy kilos, then literally just seventy kilos, you literally multiply

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<v Speaker 2>seventy by one point six and that's how much protein

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<v Speaker 2>you should be having a day, and that varies.

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<v Speaker 1>What does that much protein actually look like?

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<v Speaker 2>To be honest, it's quite difficult for a lot of women.

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<v Speaker 2>It's quite difficult for me to hit my protein goals

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<v Speaker 2>every day. But it looks like having one hundred and

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<v Speaker 2>fifty grams of chicken breast for lunch, another one hundred

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<v Speaker 2>and fifty grams of chicken breast or similar for dinner,

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<v Speaker 2>having two to three eggs in the morning.

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<v Speaker 1>So the protein is key.

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<v Speaker 2>Protein is key. However, I just interviewed one of the

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<v Speaker 2>biggest scientists in protein, so he was actually responsible for

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<v Speaker 2>the twin study that was actually documented on Netflix, and

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<v Speaker 2>he said something really interesting to me. He noted that

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<v Speaker 2>muscle mass is actually muscle mass, and strength is actually

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<v Speaker 2>ninety percent resistance training and ten percent protein. So I

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<v Speaker 2>was even fed this lie. I was even fed this

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<v Speaker 2>lie that we needed we needed so much protein to

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<v Speaker 2>gain muscle mass. But it turns out that if you're

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<v Speaker 2>not actually stimulating the mechana receptors. As I mentioned earlier,

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<v Speaker 2>if you're not even lifting heavy, but you're meeting your

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<v Speaker 2>protein requirement needs, it doesn't even matter. But I just

0:13:32.407 --> 0:13:36.247
<v Speaker 2>want to add on top of that as well. Protein

0:13:36.367 --> 0:13:41.687
<v Speaker 2>also has other wonders where you can increase your metabolic

0:13:41.767 --> 0:13:43.567
<v Speaker 2>rate by eating it. So it takes a lot to

0:13:43.647 --> 0:13:47.167
<v Speaker 2>digest protein. So once you eat protein, you're also burning

0:13:47.207 --> 0:13:51.287
<v Speaker 2>calories and it keeps you full of for longer if

0:13:51.287 --> 0:13:54.247
<v Speaker 2>you can try and prioritize at least one hundred grams

0:13:54.287 --> 0:13:54.607
<v Speaker 2>a day.

0:13:55.087 --> 0:13:57.767
<v Speaker 1>Okay, that's good, sensible advice, good for me to know.

0:13:58.007 --> 0:14:01.247
<v Speaker 1>I want to ask you about something else, vitamin D sunshine.

0:14:01.367 --> 0:14:03.847
<v Speaker 1>I'm also being told lots of vitamin D.

0:14:04.287 --> 0:14:09.367
<v Speaker 2>Vitamin D is really interesting, right we call it vitamin D,

0:14:09.567 --> 0:14:14.487
<v Speaker 2>but it's a hormone synthesized by the sun. Right now,

0:14:14.527 --> 0:14:17.367
<v Speaker 2>I live in the US, I live in New York,

0:14:17.487 --> 0:14:20.407
<v Speaker 2>so a lot of people in the US are actually

0:14:20.527 --> 0:14:25.967
<v Speaker 2>vitamin D deficient. So we measure it over here with

0:14:26.367 --> 0:14:30.567
<v Speaker 2>nanograms per deesoleader. And what we are trying to and

0:14:30.607 --> 0:14:33.327
<v Speaker 2>you can do the conversions in Australian metrics, and so

0:14:33.367 --> 0:14:37.767
<v Speaker 2>what we're trying to get everyone too is around sixty

0:14:38.087 --> 0:14:42.447
<v Speaker 2>nanograms per deesoleader, but the average is around twenty nanograms

0:14:42.447 --> 0:14:47.767
<v Speaker 2>per desoleader. This doesn't mean that you are sun deficient, right,

0:14:47.807 --> 0:14:50.327
<v Speaker 2>I mean it can, but it could mean that you

0:14:50.367 --> 0:14:56.087
<v Speaker 2>are magnesium deficient. So I've had private clients and patients

0:14:56.447 --> 0:14:59.727
<v Speaker 2>who we've worked on their vitamin D levels and we've

0:14:59.727 --> 0:15:02.487
<v Speaker 2>brought their vitamin D levels up just by supplementing them

0:15:02.607 --> 0:15:07.567
<v Speaker 2>with magnesium alone, because we need magnesium to make vitamin D.

0:15:08.087 --> 0:15:14.007
<v Speaker 2>So vitamin D is extremely, extremely important. It's involved in

0:15:14.727 --> 0:15:17.527
<v Speaker 2>many and zomatic processes in the body. So if you

0:15:17.567 --> 0:15:20.407
<v Speaker 2>want vitamin D deficient, and it's so easy to get tested,

0:15:20.487 --> 0:15:24.007
<v Speaker 2>just go to the GP, get a blood test and

0:15:24.167 --> 0:15:26.847
<v Speaker 2>you will see if you're vitamin D deficient or not.

0:15:27.167 --> 0:15:30.647
<v Speaker 1>How would you feel if you were vitamin D deficient? Like,

0:15:30.727 --> 0:15:32.207
<v Speaker 1>how would you know if you were?

0:15:33.247 --> 0:15:36.927
<v Speaker 2>That's a thing you wouldn't know. It could present as

0:15:37.167 --> 0:15:40.607
<v Speaker 2>dry skin, it could present as fatigue. It could present

0:15:40.767 --> 0:15:43.367
<v Speaker 2>as going to the gym and not getting that not

0:15:43.407 --> 0:15:47.047
<v Speaker 2>being able to lift heavy fast enough. But it's not

0:15:47.767 --> 0:15:50.327
<v Speaker 2>like a you can't get a headache and think, oh

0:15:50.327 --> 0:15:51.527
<v Speaker 2>I'm vitamin D deficient.

0:15:52.247 --> 0:15:54.447
<v Speaker 1>Yeah right, okay, And a few of those things you

0:15:54.567 --> 0:15:57.607
<v Speaker 1>just said are often symptoms that menopausal or perimenopause or

0:15:57.607 --> 0:15:59.287
<v Speaker 1>women living with anyway.

0:15:58.927 --> 0:15:59.847
<v Speaker 2>I know right.

0:16:02.487 --> 0:16:05.167
<v Speaker 1>After this break, Louise and Nicola and I discussed what

0:16:05.367 --> 0:16:08.727
<v Speaker 1>might feel like the most elusive part of this whole thing.

0:16:09.487 --> 0:16:09.927
<v Speaker 2>Sleep.

0:16:12.167 --> 0:16:15.127
<v Speaker 1>All right, I want to ask you about sleep, because

0:16:15.167 --> 0:16:18.207
<v Speaker 1>that's another thing we're being told is so important. And

0:16:18.247 --> 0:16:20.767
<v Speaker 1>we all know that that's true, of course, but sleep

0:16:20.847 --> 0:16:24.087
<v Speaker 1>hygiene is such a buzz term right now. Lots of

0:16:24.127 --> 0:16:27.367
<v Speaker 1>products we can buy to optimize our sleep and measure

0:16:27.407 --> 0:16:30.687
<v Speaker 1>our sleep and see how it's going. Sleep often becomes

0:16:30.727 --> 0:16:33.847
<v Speaker 1>a really big problem for women around this phase of life. Anyway,

0:16:34.167 --> 0:16:37.247
<v Speaker 1>We've got the anxious two am wake up that would

0:16:37.247 --> 0:16:40.407
<v Speaker 1>be very familiar to lots of our listeners. How important

0:16:40.807 --> 0:16:41.607
<v Speaker 1>is sleep?

0:16:42.647 --> 0:16:47.807
<v Speaker 2>So sleep is incredibly important. We go through many things

0:16:47.887 --> 0:16:50.367
<v Speaker 2>during sleep. Sleep is not just this thing that happens

0:16:50.447 --> 0:16:54.807
<v Speaker 2>right during sleep. We go through two different phases. We

0:16:54.927 --> 0:16:57.127
<v Speaker 2>go through non REM sleep, and then we go through

0:16:57.167 --> 0:17:00.887
<v Speaker 2>REM sleep. During the non rapid eye movement sleep, we

0:17:00.967 --> 0:17:05.127
<v Speaker 2>go through a period which is stage three deep sleep.

0:17:05.847 --> 0:17:08.847
<v Speaker 2>And I can't tell you how important this stage is

0:17:08.887 --> 0:17:10.607
<v Speaker 2>to get into and to stay into.

0:17:11.087 --> 0:17:11.287
<v Speaker 1>Right.

0:17:11.607 --> 0:17:13.527
<v Speaker 2>We don't want to just get into deep sleep for

0:17:13.727 --> 0:17:16.167
<v Speaker 2>ten minutes out of the night. We really want to

0:17:16.207 --> 0:17:19.367
<v Speaker 2>be spending maybe at least three hours of deep sleep

0:17:19.607 --> 0:17:23.407
<v Speaker 2>at night. I track my sleep, you know, rigorously, using

0:17:23.447 --> 0:17:26.527
<v Speaker 2>three different types of monitors, and I can tell you

0:17:26.527 --> 0:17:31.087
<v Speaker 2>even sometimes I am experiencing fluctuations in my sleep. So

0:17:31.607 --> 0:17:35.287
<v Speaker 2>during deep sleep, what happens is we activate this system,

0:17:35.447 --> 0:17:38.127
<v Speaker 2>which is called the glymphatic system, and this is like

0:17:38.167 --> 0:17:40.807
<v Speaker 2>a washing machine in your brain. What happens is all

0:17:40.807 --> 0:17:43.927
<v Speaker 2>of the cerebral spinal fluid goes through your brain and

0:17:43.967 --> 0:17:46.727
<v Speaker 2>cleans out all of the debris throughout the day. I'm

0:17:46.807 --> 0:17:49.887
<v Speaker 2>talking amyloid beta that builds up during the day. We've

0:17:49.887 --> 0:17:53.287
<v Speaker 2>got toxins, we've got oh the burdens. Apparently now we've

0:17:53.327 --> 0:17:57.647
<v Speaker 2>got microplastics in our brain, which was actually stated first

0:17:57.647 --> 0:18:02.087
<v Speaker 2>in an Australian study. So sleep is so important and

0:18:02.127 --> 0:18:04.367
<v Speaker 2>there's so many things that we can do to improve

0:18:04.927 --> 0:18:07.287
<v Speaker 2>both the quality of our sleep and the quantity of

0:18:07.327 --> 0:18:12.887
<v Speaker 2>our sleep. However, we now know that consistency and regularity

0:18:12.887 --> 0:18:15.807
<v Speaker 2>of sleep is more important than quantity and quality. So

0:18:16.047 --> 0:18:18.207
<v Speaker 2>going to sleep at the same time every day and

0:18:18.247 --> 0:18:19.887
<v Speaker 2>waking up at the same time every day, which is

0:18:19.927 --> 0:18:23.367
<v Speaker 2>so hard, right, I travel like every three weeks for work,

0:18:23.447 --> 0:18:27.127
<v Speaker 2>so that's incredibly hard for me. But maintaining a regular

0:18:27.447 --> 0:18:30.207
<v Speaker 2>sleep and wake up time and actually doesn't matter whether

0:18:30.247 --> 0:18:35.167
<v Speaker 2>you're sleeping twelve pm till eight am, all right or

0:18:35.287 --> 0:18:38.607
<v Speaker 2>ten pm till six am is based on your chronotype.

0:18:38.607 --> 0:18:41.447
<v Speaker 2>And you can take a chronotype quiz online. Just type

0:18:41.487 --> 0:18:44.327
<v Speaker 2>it in. Take a quiz figure out whether you're an

0:18:44.327 --> 0:18:47.087
<v Speaker 2>early bird or a night owl, and you can go

0:18:47.127 --> 0:18:48.887
<v Speaker 2>to sleep at whatever time that you like.

0:18:49.207 --> 0:18:51.647
<v Speaker 1>There used to be saying that, like the hours before

0:18:52.607 --> 0:18:55.527
<v Speaker 1>midnight are worth more than the sleep you get after.

0:18:55.927 --> 0:18:58.447
<v Speaker 1>Is that true? No?

0:18:58.847 --> 0:19:00.967
<v Speaker 2>I thought that was true as well. But I sit

0:19:01.007 --> 0:19:03.247
<v Speaker 2>on the board with one of the most well known

0:19:03.287 --> 0:19:07.207
<v Speaker 2>sleep doctors and we had dinner probably i would say,

0:19:07.247 --> 0:19:09.207
<v Speaker 2>two months ago, and I brought this up with here

0:19:09.287 --> 0:19:11.847
<v Speaker 2>and he slammed the table. He's like, stop saying this,

0:19:11.927 --> 0:19:14.487
<v Speaker 2>And he explained it to me that it's built on chronotypes.

0:19:14.887 --> 0:19:17.607
<v Speaker 1>Tell me what your sleep hygen looks like to get

0:19:17.647 --> 0:19:19.807
<v Speaker 1>the kind of sleep that you do, Oh, tell me.

0:19:21.847 --> 0:19:24.927
<v Speaker 2>So it's really important for me to be able to

0:19:25.967 --> 0:19:28.447
<v Speaker 2>bring my nervous system down prior to sleep. So a

0:19:28.447 --> 0:19:31.367
<v Speaker 2>lot of people, if you work in a sleep lab right,

0:19:31.447 --> 0:19:35.167
<v Speaker 2>for example, and you get a patient, you're often asked

0:19:35.207 --> 0:19:37.567
<v Speaker 2>two things. Do you have problem falling asleep or trouble

0:19:37.607 --> 0:19:42.207
<v Speaker 2>staying asleep? And it varies across the board. So for me,

0:19:42.527 --> 0:19:44.527
<v Speaker 2>I sleep first of all, i sleep in a pitch

0:19:44.647 --> 0:19:48.567
<v Speaker 2>black room, so I've got blackout curtains. I wear religiously

0:19:48.607 --> 0:19:51.407
<v Speaker 2>an eyemask every night. Even though I've got blackout curtains,

0:19:51.407 --> 0:19:53.927
<v Speaker 2>i still wear an eye mask. I sleep on a

0:19:53.967 --> 0:19:57.487
<v Speaker 2>temperature controlled mattress, and i know not everyone can do that,

0:19:57.567 --> 0:20:00.047
<v Speaker 2>but it's a bit fancy, but it basically I have

0:20:00.087 --> 0:20:02.567
<v Speaker 2>an app on my phone and I can control the

0:20:03.167 --> 0:20:05.567
<v Speaker 2>temperature of the bed, so it goes cold and then

0:20:05.687 --> 0:20:09.287
<v Speaker 2>hot and all throughout the night. I have said it

0:20:09.487 --> 0:20:16.567
<v Speaker 2>at around fifty nine degrees fahrenheit, but it's actually separated

0:20:16.647 --> 0:20:21.087
<v Speaker 2>into cycles, so it matches. It knows Louisa's in deep sleep,

0:20:21.127 --> 0:20:23.207
<v Speaker 2>so I'm going to bring the temperature of the bed down.

0:20:23.847 --> 0:20:26.607
<v Speaker 2>Louisa is in light sleep, so I'm going to bring

0:20:26.647 --> 0:20:28.487
<v Speaker 2>it down. I'm going to bring it up a bit more,

0:20:28.647 --> 0:20:31.367
<v Speaker 2>and I've got an alarm on it. I'm like, well, bed,

0:20:31.967 --> 0:20:35.647
<v Speaker 2>wake me up at seven am, so it starts to

0:20:35.727 --> 0:20:38.327
<v Speaker 2>heat up at six point thirty in the morning because

0:20:38.407 --> 0:20:42.087
<v Speaker 2>heat is actually what wakes us up. Well, heat and light.

0:20:42.167 --> 0:20:44.647
<v Speaker 2>But it's like when the sun comes up, it warms

0:20:44.647 --> 0:20:47.527
<v Speaker 2>your body, which then releases quartersole, and quartersole is what

0:20:47.607 --> 0:20:50.527
<v Speaker 2>wakes you up. Right, So I've got the bed to

0:20:50.607 --> 0:20:52.527
<v Speaker 2>heat up half an hour prior to waking.

0:20:53.127 --> 0:20:55.647
<v Speaker 1>Look that sounds awesome. Do you use mouth tape? I

0:20:55.647 --> 0:20:57.007
<v Speaker 1>see mouth tape everywhere.

0:20:57.687 --> 0:21:01.407
<v Speaker 2>I sometimes do. I don't think it plays as big

0:21:01.407 --> 0:21:03.167
<v Speaker 2>of a role as what we think. I think that's

0:21:03.167 --> 0:21:06.447
<v Speaker 2>more in line with the beauty hacks. If you will, so,

0:21:07.047 --> 0:21:09.207
<v Speaker 2>I don't mouth theare but I also don't mouthbreak.

0:21:09.967 --> 0:21:12.567
<v Speaker 1>So if I don't have a temperature controlled mattress and

0:21:12.607 --> 0:21:15.327
<v Speaker 1>perfect blackout, the best thing I can do to get

0:21:15.327 --> 0:21:18.087
<v Speaker 1>myself in a good place for sleep is to wind down. Yes,

0:21:18.447 --> 0:21:22.007
<v Speaker 1>we've all heard no phones, no blue light, how long

0:21:22.047 --> 0:21:25.247
<v Speaker 1>before bed? And also I hear the longevity guys saying

0:21:25.487 --> 0:21:27.647
<v Speaker 1>you should stop eating a long time before you go

0:21:27.727 --> 0:21:29.687
<v Speaker 1>to sleep. Does that make a big difference?

0:21:30.887 --> 0:21:34.847
<v Speaker 2>So when we eat, it raises our core body temperature. Now,

0:21:35.167 --> 0:21:37.327
<v Speaker 2>in order to fall asleep and stay asleep, our core

0:21:37.367 --> 0:21:39.727
<v Speaker 2>body temperature needs to drop at least two degrees. This

0:21:39.847 --> 0:21:42.807
<v Speaker 2>is why I sleep on a temperature controlled mattress. You

0:21:42.847 --> 0:21:44.807
<v Speaker 2>don't want to be eating too close to bedtime. I

0:21:44.927 --> 0:21:47.327
<v Speaker 2>usually say, make sure you've had your last meal an

0:21:47.407 --> 0:21:50.367
<v Speaker 2>hour and a half to two hours prior to going

0:21:50.407 --> 0:21:53.967
<v Speaker 2>to bed, and that's to allow for digestion, right, anything

0:21:53.967 --> 0:21:59.287
<v Speaker 2>above that, right, I mean, Brian Johnson is having his

0:21:59.407 --> 0:22:01.247
<v Speaker 2>last meal at eleven am, and I think that's just

0:22:01.567 --> 0:22:05.687
<v Speaker 2>really really poor education and marketing for the world. That is,

0:22:06.007 --> 0:22:10.287
<v Speaker 2>in my opinion, stupid. So I think that's in line

0:22:10.327 --> 0:22:11.047
<v Speaker 2>with females.

0:22:11.167 --> 0:22:14.367
<v Speaker 1>So it's also that realistic to most people's lives.

0:22:14.447 --> 0:22:17.687
<v Speaker 2>Let's be honest, and I really want the women listening

0:22:17.767 --> 0:22:21.207
<v Speaker 2>to understand that we are not men, all right, So

0:22:21.727 --> 0:22:24.727
<v Speaker 2>if you hear a male say something, it might be

0:22:24.807 --> 0:22:27.087
<v Speaker 2>great for us, right, but we have to do we

0:22:27.127 --> 0:22:30.247
<v Speaker 2>have to dig a little bit deeper, and women just

0:22:30.327 --> 0:22:33.807
<v Speaker 2>need more fuel in different ranges of you know, different

0:22:33.807 --> 0:22:36.767
<v Speaker 2>stages of our lives. So I don't think that's correct.

0:22:37.327 --> 0:22:40.607
<v Speaker 2>But I also don't think eating at ten pm and

0:22:40.607 --> 0:22:42.247
<v Speaker 2>then going to bed at ten thirty is correct.

0:22:42.287 --> 0:22:44.767
<v Speaker 1>So, just while we're on what you were just saying

0:22:44.767 --> 0:22:47.007
<v Speaker 1>about the men, do you think that one of the reasons.

0:22:47.007 --> 0:22:49.487
<v Speaker 1>It can feel that the health advice coming at women,

0:22:50.007 --> 0:22:53.527
<v Speaker 1>particularly women going through hormonal changes, feels like a lot

0:22:53.687 --> 0:22:55.807
<v Speaker 1>is because we're sort of waking up to the fact

0:22:55.807 --> 0:22:58.247
<v Speaker 1>that a lot of the medical conventions we've been sold

0:22:58.767 --> 0:23:02.007
<v Speaker 1>about what's good for us, we're all about men. And

0:23:02.087 --> 0:23:04.727
<v Speaker 1>now as we're learning more about women, there's all this

0:23:04.847 --> 0:23:06.287
<v Speaker 1>new information to share.

0:23:06.847 --> 0:23:10.807
<v Speaker 2>Yes, so first of all, women very hard to study

0:23:11.567 --> 0:23:14.487
<v Speaker 2>in the lab, So a lot of the studies that

0:23:14.527 --> 0:23:17.087
<v Speaker 2>have been done have been done on men because they're easier.

0:23:17.487 --> 0:23:21.767
<v Speaker 2>Why are they easier because you have to conduct the

0:23:21.847 --> 0:23:24.927
<v Speaker 2>gold standard in academic medicine, which is called a randomized

0:23:24.967 --> 0:23:29.527
<v Speaker 2>control trial. You need women over a long period of time.

0:23:29.927 --> 0:23:33.487
<v Speaker 2>Now what happens with women, Well, we go through menopause,

0:23:33.847 --> 0:23:37.127
<v Speaker 2>so hormones change. That's going to skew the data. Some

0:23:37.207 --> 0:23:40.607
<v Speaker 2>women want to have a child with enter tain year framework,

0:23:40.807 --> 0:23:44.207
<v Speaker 2>so that skews the data. So women just became somewhat

0:23:44.247 --> 0:23:47.847
<v Speaker 2>difficult to work with, right, So therefore not a lot

0:23:47.887 --> 0:23:49.927
<v Speaker 2>of funding was placed upon them. So a lot of

0:23:49.927 --> 0:23:51.967
<v Speaker 2>the funding was placed on men because they were just

0:23:52.047 --> 0:23:57.487
<v Speaker 2>easier subjects. And then we put out all of this information.

0:23:57.607 --> 0:24:01.847
<v Speaker 2>Scientists were like, well, this fasting does this, or zone

0:24:01.887 --> 0:24:04.767
<v Speaker 2>to training does this, and it improves this, but we've

0:24:04.807 --> 0:24:09.607
<v Speaker 2>forgot to include women in that, and we just thought, Okay, well,

0:24:09.607 --> 0:24:13.087
<v Speaker 2>this study says this, but we don't really understand sex differences.

0:24:13.087 --> 0:24:17.447
<v Speaker 2>We're now becoming more attuned with sex differences between men

0:24:17.487 --> 0:24:20.567
<v Speaker 2>and women. We know that women have more estrogen receptors

0:24:20.567 --> 0:24:22.487
<v Speaker 2>in their brain than men. We know that men go

0:24:22.567 --> 0:24:25.167
<v Speaker 2>through their own type of metopause, but the average age

0:24:25.167 --> 0:24:27.367
<v Speaker 2>of metopause for a woman is fifty two. Men it's

0:24:27.407 --> 0:24:33.087
<v Speaker 2>in their seventies, so that's called andropause. So that was

0:24:33.127 --> 0:24:37.407
<v Speaker 2>why all of the marketing was really geared at men. Yeah.

0:24:37.487 --> 0:24:39.727
<v Speaker 1>Right, and now we're understanding that better. There's a lot

0:24:39.767 --> 0:24:41.167
<v Speaker 1>to learn all this.

0:24:41.287 --> 0:24:45.807
<v Speaker 2>So look, I'm I'm in neurosurgery three days a week.

0:24:46.007 --> 0:24:48.727
<v Speaker 2>I study the brain rigorously. It's all I do. It's

0:24:48.727 --> 0:24:51.327
<v Speaker 2>all I've done for the past fifteen years. And every

0:24:51.407 --> 0:24:53.727
<v Speaker 2>day I'm like, oh my gosh, I don't know that.

0:24:53.727 --> 0:24:58.487
<v Speaker 1>Much before we get to dementia and Alzheimer's. You mentioned

0:24:58.527 --> 0:25:00.647
<v Speaker 1>fasting just now, and I wanted to ask you about

0:25:00.647 --> 0:25:03.967
<v Speaker 1>eating in general. A lot of women around my age

0:25:04.407 --> 0:25:08.407
<v Speaker 1>have lived in diet culture forever, right, we've sort of

0:25:08.447 --> 0:25:12.647
<v Speaker 1>withheld food food from ourselves. We've tried a million different diets.

0:25:13.047 --> 0:25:17.127
<v Speaker 1>We've tried Atkins and keto, We've gone donat before two pm,

0:25:17.527 --> 0:25:20.247
<v Speaker 1>only at this time, not at that time. Do you

0:25:20.327 --> 0:25:23.127
<v Speaker 1>think that women, maybe a lot of women are actually

0:25:23.167 --> 0:25:26.167
<v Speaker 1>restricting themselves too much with food at this time in

0:25:26.207 --> 0:25:28.127
<v Speaker 1>their life rather than not enough.

0:25:28.607 --> 0:25:33.367
<v Speaker 2>Yeah. I think women just don't understand food, right. We

0:25:33.567 --> 0:25:36.487
<v Speaker 2>just you know, there's so much to learn. Fasting is

0:25:37.567 --> 0:25:41.007
<v Speaker 2>both beneficial and can be detrimental. It depends and even

0:25:41.207 --> 0:25:44.407
<v Speaker 2>with women just because we're all it depends on stages

0:25:44.487 --> 0:25:48.087
<v Speaker 2>of menstrual cycle. What if you are planning for a pregnancy,

0:25:48.167 --> 0:25:51.407
<v Speaker 2>you're starving yourself and then you claim that you're infertile,

0:25:51.487 --> 0:25:55.247
<v Speaker 2>but maybe you're just not eating enough to produce the

0:25:55.327 --> 0:25:59.247
<v Speaker 2>necessary amount of estrogen to go into ovulation, etc. So

0:26:00.087 --> 0:26:03.807
<v Speaker 2>fasting is great. It can turn on autophagy, which is

0:26:04.127 --> 0:26:08.367
<v Speaker 2>whatever they can actually stimulate stem cells. But I think

0:26:08.527 --> 0:26:13.847
<v Speaker 2>that women should maybe move away from that and maybe

0:26:13.847 --> 0:26:18.567
<v Speaker 2>move towards understanding macro nutrients like how much protein do

0:26:18.607 --> 0:26:21.167
<v Speaker 2>I need in a day, and how can I maybe

0:26:21.247 --> 0:26:26.287
<v Speaker 2>get off sugar and saturated fats and ultra processed foods

0:26:26.287 --> 0:26:30.727
<v Speaker 2>and eat a really good lean diet and exercise. It's

0:26:30.767 --> 0:26:34.687
<v Speaker 2>not rocket science, right, It's like, you know, then we

0:26:34.687 --> 0:26:37.487
<v Speaker 2>can look at calories in, calories out, but it's not

0:26:37.607 --> 0:26:40.527
<v Speaker 2>rocket science. If you are lifting and you are working

0:26:40.567 --> 0:26:42.967
<v Speaker 2>out every day and moving your body, getting your ten

0:26:43.007 --> 0:26:48.407
<v Speaker 2>thousand steps and eating a whole food diet without going overboard,

0:26:49.047 --> 0:26:51.487
<v Speaker 2>I mean, that's the secret, sauce.

0:26:52.647 --> 0:26:55.687
<v Speaker 1>It's really interesting to shift to that. Nourish yourself rather

0:26:55.727 --> 0:26:58.447
<v Speaker 1>than punish yourself. You know, I think a lot of

0:26:58.487 --> 0:27:00.607
<v Speaker 1>women have lived a lot of years of life. I

0:27:00.607 --> 0:27:03.447
<v Speaker 1>shouldn't eat that. I can't have that. I'm bad if

0:27:03.447 --> 0:27:05.487
<v Speaker 1>my lunch is too big. It's like we've got a

0:27:05.527 --> 0:27:07.807
<v Speaker 1>lot of emotion attached to it and we need to shift.

0:27:07.807 --> 0:27:10.647
<v Speaker 1>Oh yeah, to a nourish active right yeah.

0:27:11.207 --> 0:27:15.647
<v Speaker 2>Nourishing your body and eating well to lift heavy is

0:27:15.687 --> 0:27:18.927
<v Speaker 2>I think the new sexy. That's what we have to

0:27:18.967 --> 0:27:21.807
<v Speaker 2>start to think. You know, skinny frail is just not

0:27:21.927 --> 0:27:25.047
<v Speaker 2>going to cut it anymore. If you want to lift heavy,

0:27:25.407 --> 0:27:27.247
<v Speaker 2>if you want to have the energy, and if you

0:27:27.247 --> 0:27:29.767
<v Speaker 2>don't want to fall and break your hip, well, you

0:27:29.807 --> 0:27:31.847
<v Speaker 2>have to get used to eating. You have to get

0:27:31.927 --> 0:27:36.367
<v Speaker 2>used to eating. The rainbow I just did a podcast

0:27:36.487 --> 0:27:40.487
<v Speaker 2>with doctor Tim Spector, who's a professor and he is

0:27:40.487 --> 0:27:43.527
<v Speaker 2>an epidemiologist who looks into the gut microbiome, and he

0:27:43.607 --> 0:27:49.167
<v Speaker 2>was telling me how eating the rainbow is really important

0:27:49.287 --> 0:27:53.967
<v Speaker 2>and that our gut microbiome is very much correlated to

0:27:54.327 --> 0:27:59.447
<v Speaker 2>diseases such as cardiovascular disease, cancer, Alzheimer's disease. So feeding

0:27:59.447 --> 0:28:04.807
<v Speaker 2>your microbiome, getting the necessary amount of nutrients is going

0:28:04.847 --> 0:28:06.487
<v Speaker 2>to help you throughout midlife.

0:28:06.807 --> 0:28:08.767
<v Speaker 1>Also, the rainbow is a nice pet. Did to remember,

0:28:08.807 --> 0:28:10.607
<v Speaker 1>eat the rain in bone. Make it as simple as

0:28:10.607 --> 0:28:13.687
<v Speaker 1>you can. Yeah, okay, you talked before about if you

0:28:13.727 --> 0:28:16.247
<v Speaker 1>want to not fall and break a hip. This is

0:28:16.287 --> 0:28:18.447
<v Speaker 1>a large part of why we're telling women to eat

0:28:18.487 --> 0:28:23.127
<v Speaker 1>so well and lift heavy. Right, it's trying to avoid osteoporosis.

0:28:23.287 --> 0:28:25.367
<v Speaker 1>Is that right? Is that what we're all trying to avoid?

0:28:26.127 --> 0:28:33.487
<v Speaker 2>Yep. Yep Osteoporosis is something that occurs during the late stages,

0:28:33.527 --> 0:28:38.127
<v Speaker 2>like postmenopausal women, just because of the depletion of estrogen.

0:28:38.207 --> 0:28:43.047
<v Speaker 2>We have estrogen receptors on our bones, so if they

0:28:43.087 --> 0:28:47.087
<v Speaker 2>are not stimulated through estrogen, and this is even if

0:28:47.127 --> 0:28:50.167
<v Speaker 2>you're you're taking hit for example, if you're you're getting

0:28:50.207 --> 0:28:53.607
<v Speaker 2>on hormones even if it's not. We need to stimulate

0:28:54.127 --> 0:28:59.767
<v Speaker 2>our bone mass because bone mass obviously reduces the risk

0:28:59.887 --> 0:29:04.287
<v Speaker 2>of osteoporosis and fractures. But what happens is we need

0:29:04.327 --> 0:29:09.167
<v Speaker 2>to stimulate something called osteoblasts. Okay, and that's the creation

0:29:09.407 --> 0:29:12.927
<v Speaker 2>of these new bone cells. But what happens is we

0:29:13.007 --> 0:29:17.687
<v Speaker 2>get during menopause a huge turnover of osteoclass, so the

0:29:17.767 --> 0:29:20.247
<v Speaker 2>breaking down of the bones at a much faster rate

0:29:20.327 --> 0:29:24.807
<v Speaker 2>than the osteoblasts. So we're not regenerating our bone cells

0:29:24.847 --> 0:29:28.007
<v Speaker 2>as much. Now, how do we overcome that? Well, Vitamin

0:29:28.087 --> 0:29:32.687
<v Speaker 2>D actually is incredibly important for that because our bones

0:29:32.687 --> 0:29:35.367
<v Speaker 2>are made of many things, so vitamin D can help

0:29:35.447 --> 0:29:40.247
<v Speaker 2>you offset that. But nothing, and I mean nothing, compares

0:29:40.647 --> 0:29:44.647
<v Speaker 2>to working out at the gym and lifting heavy like

0:29:44.727 --> 0:29:48.527
<v Speaker 2>I mentioned earlier, weight training, mechanical loading.

0:29:52.967 --> 0:29:55.527
<v Speaker 1>After this break, I asked Louisa about what most of

0:29:55.607 --> 0:29:58.727
<v Speaker 1>us fear the most when we think about getting older, dementia,

0:29:59.207 --> 0:30:08.367
<v Speaker 1>Alzheimer's disease, and cognitive decline. I've heard you say that

0:30:08.407 --> 0:30:13.767
<v Speaker 1>your mission to eradicate Alzheimer's disease? Now, am I incorrect?

0:30:13.807 --> 0:30:17.647
<v Speaker 1>When I'm sometimes saying dementia and sometimes saying Alzheimer's Are

0:30:17.687 --> 0:30:20.407
<v Speaker 1>they different things? Just so I've got my language right.

0:30:20.727 --> 0:30:25.007
<v Speaker 2>Yes, So dementia is the umbrella term that is used

0:30:25.327 --> 0:30:31.327
<v Speaker 2>just to speak about a deficit in our cognitive abilities.

0:30:31.367 --> 0:30:37.007
<v Speaker 2>Now underneath dementia sits Alzheimer's disease, dementia with Lewis body

0:30:38.247 --> 0:30:42.167
<v Speaker 2>Parkinson's dementia front to temporal dementia. The reason why we

0:30:42.327 --> 0:30:45.967
<v Speaker 2>know Alzheimer's disease is because it is the most prevalent

0:30:46.007 --> 0:30:50.127
<v Speaker 2>out of all of the dementia's Alzheimer's dementia fifty five

0:30:50.207 --> 0:30:53.167
<v Speaker 2>million people that I actually around sixty million people worldwide

0:30:53.247 --> 0:30:55.687
<v Speaker 2>have this disease. That number is going to triple by

0:30:55.687 --> 0:30:58.887
<v Speaker 2>the year twenty fifty. So Alzheimer's disease is different. They've

0:30:58.927 --> 0:31:00.567
<v Speaker 2>all got different pathologies.

0:31:01.047 --> 0:31:02.327
<v Speaker 1>Why is it going to triple?

0:31:02.927 --> 0:31:07.367
<v Speaker 2>We have substantial evidence to show that lifestyle and environment

0:31:07.727 --> 0:31:11.007
<v Speaker 2>affects the rates of our Ceimer's disease. So I mentioned

0:31:11.007 --> 0:31:13.327
<v Speaker 2>around sixty million people worldwide. If you have a look

0:31:13.327 --> 0:31:16.127
<v Speaker 2>across the board, around ninety five percent of these people

0:31:16.807 --> 0:31:21.727
<v Speaker 2>got Alzheimer's disease through lifestyle, not because of a genetic makeup.

0:31:22.047 --> 0:31:23.967
<v Speaker 1>So that's why when you say your mission is to

0:31:24.007 --> 0:31:28.007
<v Speaker 1>eradicate it, you believe this is preventable with lifestyle changes.

0:31:28.807 --> 0:31:32.487
<v Speaker 2>I believe it is a one hundred percent preventable disease.

0:31:32.967 --> 0:31:34.767
<v Speaker 1>So a lot of the people listening to this will

0:31:34.767 --> 0:31:38.887
<v Speaker 1>have loved ones who've been through this, and again maybe

0:31:38.927 --> 0:31:42.767
<v Speaker 1>the umbrella term dementia, maybe not specifically Alzheimer's, and a

0:31:42.767 --> 0:31:45.407
<v Speaker 1>lot of midlife women are terrified that's what's going to

0:31:45.407 --> 0:31:49.007
<v Speaker 1>happen to them, because sometimes they've seen really distressing things

0:31:49.047 --> 0:31:51.927
<v Speaker 1>happen to their loved ones in this space. So, of

0:31:52.007 --> 0:31:53.967
<v Speaker 1>all the things we've been talking about today, is that

0:31:54.087 --> 0:31:57.527
<v Speaker 1>part of what will help this prevention or is this

0:31:57.607 --> 0:31:58.607
<v Speaker 1>the whole separate thing.

0:31:59.727 --> 0:32:03.567
<v Speaker 2>So, first of all, it's interesting to note that, yeah,

0:32:03.687 --> 0:32:07.767
<v Speaker 2>one in three people, you'll you know, you look around you.

0:32:08.047 --> 0:32:09.527
<v Speaker 2>If you're in a room with two other people, one

0:32:09.527 --> 0:32:12.247
<v Speaker 2>of you is going to get the disease. Two out

0:32:12.247 --> 0:32:15.687
<v Speaker 2>of three cases of Alzheimer's disease is female, which is

0:32:15.727 --> 0:32:20.127
<v Speaker 2>even more scarier for females. Good and bad news. Right,

0:32:20.687 --> 0:32:24.647
<v Speaker 2>when we talk about genetics, there is a difference between

0:32:24.727 --> 0:32:30.087
<v Speaker 2>genetic risk factors and genetic mutations. Genetic mutations are mistakes

0:32:30.167 --> 0:32:32.847
<v Speaker 2>in the genetic code. For example, if you've got a

0:32:32.887 --> 0:32:38.287
<v Speaker 2>genetic mutation on chromosome four, you will get Huntington's disease. Okay,

0:32:39.247 --> 0:32:43.167
<v Speaker 2>we have When it comes to Alzheimer's disease, there's only

0:32:43.367 --> 0:32:49.167
<v Speaker 2>three genetic mutations involved in the disease. That's Presnell and one,

0:32:49.887 --> 0:32:55.327
<v Speaker 2>Presnell and two, and the APP gene. That only accounts

0:32:55.327 --> 0:32:57.647
<v Speaker 2>for about I would say point five percent of the

0:32:57.647 --> 0:33:01.967
<v Speaker 2>Alzheimer's disease cases. The other part of it is genetic

0:33:02.087 --> 0:33:05.527
<v Speaker 2>risk factors. You've probably heard of the APE four gene.

0:33:06.047 --> 0:33:09.047
<v Speaker 2>This is a risk factor gene. Now we've all got

0:33:09.847 --> 0:33:15.687
<v Speaker 2>the apoe gene, the APO lipoprotein epsilon gene, and we

0:33:15.807 --> 0:33:18.567
<v Speaker 2>get two allyls. We get one from mum, one from Dad,

0:33:18.567 --> 0:33:21.927
<v Speaker 2>and where it consists of a po E two, three

0:33:22.087 --> 0:33:26.247
<v Speaker 2>and four. If we get two copies of the Apo

0:33:26.407 --> 0:33:28.687
<v Speaker 2>E two gene, for example, which is extremely rare, but

0:33:28.767 --> 0:33:33.967
<v Speaker 2>Apo E two is a protective, protective gene. So if

0:33:34.047 --> 0:33:36.807
<v Speaker 2>you've got at least one ALLYL, then you're in a

0:33:36.807 --> 0:33:39.567
<v Speaker 2>really good place. Then you can be an E three

0:33:39.647 --> 0:33:42.567
<v Speaker 2>E three which doesn't raise your risk at all of

0:33:42.607 --> 0:33:45.047
<v Speaker 2>getting the disease, and it doesn't lower your risk. It's

0:33:45.087 --> 0:33:48.767
<v Speaker 2>the average. I'm an E three E three carrier. I've

0:33:48.807 --> 0:33:51.287
<v Speaker 2>had a patient who was E three E two, which

0:33:51.367 --> 0:33:53.807
<v Speaker 2>was phenomenal. That's what I wish I had. But you

0:33:53.847 --> 0:33:57.007
<v Speaker 2>don't determine that your parents do. Then we've got the

0:33:57.047 --> 0:33:59.727
<v Speaker 2>APO e four gene. Now, the APO e four you

0:33:59.767 --> 0:34:02.767
<v Speaker 2>can either have one copy or you can have two copies.

0:34:03.167 --> 0:34:07.287
<v Speaker 2>Now Chris Hamsworth has two copies of the gene, which

0:34:07.327 --> 0:34:11.687
<v Speaker 2>means that he raises his risk over ten times of

0:34:11.727 --> 0:34:15.807
<v Speaker 2>getting the disease. And this gene is involved in what

0:34:15.847 --> 0:34:19.967
<v Speaker 2>we call lipid metabolism. So basically in our brain, we

0:34:20.087 --> 0:34:24.927
<v Speaker 2>have different transporters that help transport fats, and so we

0:34:24.967 --> 0:34:28.687
<v Speaker 2>can utilize fat in our brain, different types of fats. Right,

0:34:29.487 --> 0:34:32.047
<v Speaker 2>and if we have the APO e four gene as

0:34:32.087 --> 0:34:35.127
<v Speaker 2>opposed to the APOE two, the APO e four basically

0:34:35.487 --> 0:34:40.047
<v Speaker 2>becomes a dumb transport. It doesn't help us. It doesn't

0:34:40.087 --> 0:34:42.847
<v Speaker 2>allow us to transport fat as well as we do.

0:34:42.927 --> 0:34:46.207
<v Speaker 2>So what ends up happening, Well, our brain is the

0:34:46.247 --> 0:34:49.367
<v Speaker 2>most vascular rich organ in the entire body, so then

0:34:49.407 --> 0:34:54.087
<v Speaker 2>we end up getting the accumulation of fat in the

0:34:54.167 --> 0:34:57.447
<v Speaker 2>vessels of our brain. So just like we do with

0:34:57.527 --> 0:35:01.367
<v Speaker 2>cardiovascular disease, which is an occlusion in a blood vessel

0:35:01.487 --> 0:35:04.007
<v Speaker 2>because of the build up of PLAK can happen in

0:35:04.047 --> 0:35:07.447
<v Speaker 2>our brain. Now, this could lead to a stroke, or

0:35:07.487 --> 0:35:10.567
<v Speaker 2>it could lead to an occlusion in one of the

0:35:10.647 --> 0:35:13.847
<v Speaker 2>vessels in the brain, which stops our brain from functioning correctly.

0:35:14.607 --> 0:35:17.687
<v Speaker 2>So the APO E four gene raises your risk of

0:35:17.727 --> 0:35:20.207
<v Speaker 2>getting the disease, but it's not a foe gun conclusion

0:35:20.687 --> 0:35:23.007
<v Speaker 2>if you are an E four E four carrier. By

0:35:23.047 --> 0:35:27.487
<v Speaker 2>the way, I think everybody should get tested. Everyone can

0:35:27.487 --> 0:35:31.607
<v Speaker 2>get tested, and if you're scared, it's just like figuring

0:35:31.647 --> 0:35:34.047
<v Speaker 2>out whether the bus is coming if you're on the road.

0:35:34.167 --> 0:35:36.887
<v Speaker 2>You want to know what you're up against. You don't

0:35:36.887 --> 0:35:37.927
<v Speaker 2>have to do it, but it's.

0:35:37.847 --> 0:35:38.367
<v Speaker 1>Nice to know.

0:35:38.847 --> 0:35:40.927
<v Speaker 2>So let's just say you do have either one copy

0:35:41.007 --> 0:35:42.727
<v Speaker 2>or two copies. It just means you have to be

0:35:42.767 --> 0:35:47.007
<v Speaker 2>a bit more vigilant with your lifestyle interventions. It may

0:35:47.127 --> 0:35:52.927
<v Speaker 2>mean really honing down with your cholesterol panel right, looking

0:35:53.007 --> 0:35:57.007
<v Speaker 2>at your LDL cholesterol, looking at your APO B cholesterol.

0:35:57.407 --> 0:35:59.647
<v Speaker 2>We know that especially in women, and this was a

0:35:59.647 --> 0:36:02.687
<v Speaker 2>really well known study that was released, especially in women

0:36:03.327 --> 0:36:06.567
<v Speaker 2>who are E four carriers. You want to maintain a

0:36:06.967 --> 0:36:11.607
<v Speaker 2>LDL cholesterol level below seven that's American units. So we

0:36:11.727 --> 0:36:17.527
<v Speaker 2>know that we need to really really consider cardiovascular disease

0:36:17.647 --> 0:36:18.407
<v Speaker 2>risk as well.

0:36:19.527 --> 0:36:22.687
<v Speaker 1>So assuming that testing is available, but even if not,

0:36:22.887 --> 0:36:25.647
<v Speaker 1>we should be considering all these lifestyle choices we're talking

0:36:25.647 --> 0:36:29.527
<v Speaker 1>about today to be helpful in safeguarding against Alzheimer's as

0:36:29.527 --> 0:36:31.647
<v Speaker 1>well as cardio issues and all the other things we

0:36:31.727 --> 0:36:33.767
<v Speaker 1>might worry about in terms of our aging bodies.

0:36:34.407 --> 0:36:38.007
<v Speaker 2>Yeah, there's a real nice saying, which is what's good

0:36:38.007 --> 0:36:41.087
<v Speaker 2>for the heart is good for the brain. So just

0:36:41.167 --> 0:36:45.247
<v Speaker 2>remember that even if you don't have an E four copy,

0:36:45.567 --> 0:36:48.247
<v Speaker 2>you are still at risk of getting Alzheimer's disease if

0:36:48.287 --> 0:36:50.607
<v Speaker 2>you do not sleep well, if you do not exercise

0:36:50.647 --> 0:36:54.207
<v Speaker 2>every day, if you do not lower your stress, if

0:36:54.247 --> 0:36:57.247
<v Speaker 2>you do not look at your micro nutrient profiles.

0:36:57.927 --> 0:37:00.727
<v Speaker 1>So to recap, if you are going to tell midlife

0:37:00.727 --> 0:37:02.887
<v Speaker 1>women who are totally lost when it comes to how

0:37:02.887 --> 0:37:06.687
<v Speaker 1>to care for themselves, what should they start doing today?

0:37:07.647 --> 0:37:11.007
<v Speaker 2>I have this pyramid and the pyramid at the bottom

0:37:11.007 --> 0:37:15.647
<v Speaker 2>of the pyramid for you to age well sits exercise.

0:37:16.247 --> 0:37:20.047
<v Speaker 2>It is the ultimate, in my opinion, the ultimate elixa

0:37:20.367 --> 0:37:23.127
<v Speaker 2>for longevity and brain health. So we really want to

0:37:23.647 --> 0:37:27.567
<v Speaker 2>hone in the exercise. On top of that is sleep,

0:37:27.967 --> 0:37:31.167
<v Speaker 2>and then it's nutrition. I would definitely recommend everybody getting

0:37:31.207 --> 0:37:34.127
<v Speaker 2>a blood test, figure out what you might be deficient in,

0:37:34.567 --> 0:37:37.927
<v Speaker 2>figure out are you perimenopausal? Is do you need to

0:37:38.007 --> 0:37:42.607
<v Speaker 2>discuss hormone replacement therapy with your obgyn. These are the

0:37:42.607 --> 0:37:44.367
<v Speaker 2>things that we need to be doing. But the biggest

0:37:44.407 --> 0:37:47.847
<v Speaker 2>bang for your buck. Oh and also lower the bad

0:37:47.927 --> 0:37:51.007
<v Speaker 2>stress that comes into your life and manage anxiety. If

0:37:51.007 --> 0:37:51.647
<v Speaker 2>you can.

0:37:56.407 --> 0:37:59.567
<v Speaker 1>There, you are friends. If there's one takeaway from that

0:37:59.567 --> 0:38:03.847
<v Speaker 1>that I've internalized, it's exercise that the pyramid for well

0:38:03.887 --> 0:38:11.887
<v Speaker 1>being goes. Exercise, then sleep, then nutrition of course protein, creatine, magnesium, sleep.

0:38:12.127 --> 0:38:14.087
<v Speaker 1>If you like me, you probably need to listen to

0:38:14.127 --> 0:38:16.367
<v Speaker 1>this again and write some things down. And the other

0:38:16.447 --> 0:38:19.087
<v Speaker 1>most important thing that Luisa said to us is to

0:38:19.167 --> 0:38:22.847
<v Speaker 1>remember that we are not men as we start to

0:38:22.927 --> 0:38:26.407
<v Speaker 1>understand our bodies again and learn to care for them now,

0:38:26.807 --> 0:38:30.167
<v Speaker 1>respecting the complexities of the female body and specifically your

0:38:30.287 --> 0:38:34.527
<v Speaker 1>female body is key. Okay, friends, go and eat an

0:38:34.527 --> 0:38:38.287
<v Speaker 1>egg and lift something heavy and enjoy feeling kick ass.

0:38:38.527 --> 0:38:41.247
<v Speaker 1>I will see you back here for mid season six

0:38:41.367 --> 0:38:44.447
<v Speaker 1>in a few short weeks until then. Thank you so

0:38:44.647 --> 0:38:47.367
<v Speaker 1>much for being with us through this season of mid

0:38:47.767 --> 0:38:50.407
<v Speaker 1>The executive producer of this episode is name A. Brown,

0:38:50.887 --> 0:38:54.167
<v Speaker 1>The producer is Charlie Blackman, and we've had audio production

0:38:54.367 --> 0:39:00.847
<v Speaker 1>by Jacob Brown. I'll see you next time. The information

0:39:00.967 --> 0:39:04.927
<v Speaker 1>discussed in this episode is not intended to replace professional

0:39:04.967 --> 0:39:09.847
<v Speaker 1>medical advice. Please remember that supplement availability, safety, and regulation

0:39:10.047 --> 0:39:14.447
<v Speaker 1>vary between countries, including Australia. Always seek guidance from your

0:39:14.487 --> 0:39:18.327
<v Speaker 1>GP or pharmacist and ensure any therapeutic goods are listed

0:39:18.367 --> 0:39:22.887
<v Speaker 1>on the Australian Register of Therapeutic Goods the AARTG