1 00:00:10,240 --> 00:00:12,600 Speaker 1: So a'n Stevens. Welcome to the podcast. 2 00:00:13,280 --> 00:00:15,080 Speaker 2: Doctor Paul, great to see you. 3 00:00:15,440 --> 00:00:18,360 Speaker 3: How are things And Matt, thanks for going very very 4 00:00:18,400 --> 00:00:19,880 Speaker 3: well here in Australia. 5 00:00:19,920 --> 00:00:21,800 Speaker 1: And I can see that well. I know that you're 6 00:00:21,840 --> 00:00:23,079 Speaker 1: in Aspen, Colorado. 7 00:00:23,120 --> 00:00:25,440 Speaker 3: You've got a rather nice background there, so I love 8 00:00:25,480 --> 00:00:27,040 Speaker 3: you being in Aspen, Colorado. 9 00:00:28,000 --> 00:00:30,440 Speaker 2: You know, I was born here in Colorado, so born 10 00:00:30,480 --> 00:00:33,879 Speaker 2: in these mountains and then raised in northern California, a 11 00:00:33,880 --> 00:00:36,919 Speaker 2: little town south of San Francisco. So spent a lot 12 00:00:36,960 --> 00:00:39,600 Speaker 2: of time here just growing up. And then I just 13 00:00:39,680 --> 00:00:43,640 Speaker 2: moved back pre pandemic about twenty fifteen. In the pandemic 14 00:00:43,680 --> 00:00:45,680 Speaker 2: hit and I was still going back and forth with California, 15 00:00:45,720 --> 00:00:48,479 Speaker 2: and I basically said I would absolutely never go back 16 00:00:48,479 --> 00:00:49,120 Speaker 2: to California. 17 00:00:49,280 --> 00:00:50,159 Speaker 1: So I moved back to. 18 00:00:50,080 --> 00:00:53,559 Speaker 2: Colorado full time and found myself here in the mountains. 19 00:00:53,640 --> 00:00:57,600 Speaker 1: And Jesus, a lot of active people around there, isn't. 20 00:00:57,440 --> 00:01:01,560 Speaker 2: There Incredibly Yeah, it doesn't matter how active you are, 21 00:01:01,600 --> 00:01:08,039 Speaker 2: there's always someone more active. Like, yeah, we're a little maniacal, 22 00:01:08,240 --> 00:01:09,600 Speaker 2: but in good ways. 23 00:01:09,880 --> 00:01:13,800 Speaker 1: Yeah, not very cold. I mean, you are a scientist, 24 00:01:13,880 --> 00:01:14,680 Speaker 1: data visionary. 25 00:01:14,720 --> 00:01:19,440 Speaker 3: You're also a keynote speaker, and you kind of play 26 00:01:19,440 --> 00:01:23,800 Speaker 3: in the space of human behavior biology and also the 27 00:01:23,840 --> 00:01:28,800 Speaker 3: intersection with AI and so just give people a bit 28 00:01:28,840 --> 00:01:32,199 Speaker 3: of a sense of your background and how you ended 29 00:01:32,280 --> 00:01:33,600 Speaker 3: up where you are right now. 30 00:01:34,160 --> 00:01:34,640 Speaker 1: Professor. 31 00:01:34,959 --> 00:01:39,440 Speaker 2: Yeah, So education wise, I was I studied biotechnology and 32 00:01:39,480 --> 00:01:42,679 Speaker 2: then molecular biology. You were my skills when I was 33 00:01:42,680 --> 00:01:45,240 Speaker 2: in the lab. So I worked in small molecule drug 34 00:01:45,280 --> 00:01:49,040 Speaker 2: therapeutics in biotech for really the first third of my 35 00:01:49,120 --> 00:01:52,120 Speaker 2: career and it was an amazing time. We sequence the 36 00:01:52,160 --> 00:01:55,160 Speaker 2: human genome and it's like, wait, what's next. You know, 37 00:01:55,200 --> 00:01:58,120 Speaker 2: the division back then was knowing the genome would help 38 00:01:58,200 --> 00:02:00,560 Speaker 2: unlock you know, really the future of meta but that 39 00:02:00,640 --> 00:02:02,400 Speaker 2: wasn't quite the case. You know, we didn't really take 40 00:02:02,440 --> 00:02:04,880 Speaker 2: into account. You know, you have the genem over here, 41 00:02:04,920 --> 00:02:07,400 Speaker 2: you have the protium over here, but in between you 42 00:02:07,480 --> 00:02:13,400 Speaker 2: have you know, essentially the gene regulation. So epigenetics, epigenomics, transcriptome, metabolam, 43 00:02:13,480 --> 00:02:16,400 Speaker 2: all those pieces. So it's been quite fun though over 44 00:02:16,400 --> 00:02:19,120 Speaker 2: these last number of years. My research then went into 45 00:02:19,280 --> 00:02:22,399 Speaker 2: data science, so really focusing on user measurement and optimization. 46 00:02:23,000 --> 00:02:25,640 Speaker 2: That was in my twenties, and then further I began 47 00:02:25,720 --> 00:02:29,680 Speaker 2: doing trathlons and iron man distances, and it was through 48 00:02:30,160 --> 00:02:33,560 Speaker 2: those experiences I really began to optimize my data, my 49 00:02:33,639 --> 00:02:37,480 Speaker 2: biology using data basically, and you know that idea that 50 00:02:37,560 --> 00:02:41,280 Speaker 2: when you have wearable data, really any type of data, 51 00:02:41,320 --> 00:02:43,679 Speaker 2: you know, ultimately you can start to synthesize and understand 52 00:02:43,720 --> 00:02:46,560 Speaker 2: how that can impact your body. And so it really 53 00:02:46,600 --> 00:02:51,400 Speaker 2: began using protocols at scale to optimize my biology for racing, 54 00:02:51,760 --> 00:02:54,760 Speaker 2: and that ultimately led me to my current area of research. 55 00:02:55,400 --> 00:02:59,440 Speaker 3: Ah okay, so your interest was in performance initially. 56 00:02:59,520 --> 00:03:04,320 Speaker 2: Performance consciousness, you know, kind of spanning a spectrum. But yeah, absolutely, 57 00:03:05,760 --> 00:03:08,799 Speaker 2: without being too obsessive about it. You know, I think 58 00:03:08,800 --> 00:03:12,600 Speaker 2: there's people who get absolutely obsessive about, you know, the 59 00:03:12,680 --> 00:03:14,600 Speaker 2: measurement side. I guess I would say. 60 00:03:14,440 --> 00:03:19,160 Speaker 1: So Brian Johnson springing to mind, Yeah, I. 61 00:03:19,080 --> 00:03:22,240 Speaker 2: Mean he's he's he's over here, you know, relative to measurement. 62 00:03:22,280 --> 00:03:24,239 Speaker 2: I mean most humans are over here. You know, we're 63 00:03:24,240 --> 00:03:27,440 Speaker 2: probably over here is but certainly not all the way over. 64 00:03:27,560 --> 00:03:30,280 Speaker 2: So I think it's important to have a solid regimen 65 00:03:30,360 --> 00:03:34,120 Speaker 2: and routine and what we call protocols, but also live 66 00:03:34,160 --> 00:03:35,800 Speaker 2: your life, you know as well. 67 00:03:36,520 --> 00:03:42,640 Speaker 3: And in terms of measurement and and and measurement devices, 68 00:03:42,680 --> 00:03:46,200 Speaker 3: what what sort of things do you think are useful 69 00:03:46,240 --> 00:03:49,520 Speaker 3: for people and what sort of what sort of measures 70 00:03:49,520 --> 00:03:50,680 Speaker 3: should they be looking at. 71 00:03:51,400 --> 00:03:54,920 Speaker 2: Yeah, so we spend a lot of time thinking about 72 00:03:54,960 --> 00:04:01,240 Speaker 2: longevity protocols, helped protocols, and we've analyzed tens of thousands 73 00:04:01,240 --> 00:04:03,520 Speaker 2: at this stage. And you know, we look at the 74 00:04:03,840 --> 00:04:09,160 Speaker 2: dominant themes. So you have nutrition, exercise, sleep, stress, you know, 75 00:04:09,280 --> 00:04:12,920 Speaker 2: metabolic regulation of some kind connection you know as well. 76 00:04:13,160 --> 00:04:15,280 Speaker 2: Those usually like the six areas we really you know, 77 00:04:15,720 --> 00:04:19,240 Speaker 2: think about routinely, and so generally starting with like sleep. 78 00:04:19,480 --> 00:04:21,719 Speaker 2: You know, every person we know has an issue with 79 00:04:21,839 --> 00:04:26,800 Speaker 2: sleeping or you know, maybe their gut microbiome. So sleep 80 00:04:26,880 --> 00:04:29,560 Speaker 2: as an example. There's a number of wearables that I've 81 00:04:29,600 --> 00:04:31,640 Speaker 2: used over the years. My favorite is an Aura ring 82 00:04:31,880 --> 00:04:34,800 Speaker 2: because it's really the least invasive, the least amount of EMF. 83 00:04:34,880 --> 00:04:37,919 Speaker 2: You can even turn the bluetooth off, and it's you know, 84 00:04:38,040 --> 00:04:40,679 Speaker 2: very small essentially, and so that's one of my favorite 85 00:04:41,040 --> 00:04:44,479 Speaker 2: for sleep relative to accuracy. When I'm training and doing 86 00:04:44,680 --> 00:04:47,280 Speaker 2: iron Man's or you know, trail running, I usually wear 87 00:04:47,320 --> 00:04:49,680 Speaker 2: a garment and then I also have a loop and 88 00:04:49,720 --> 00:04:51,400 Speaker 2: a fit bit, and so we test all of these 89 00:04:51,400 --> 00:04:54,280 Speaker 2: wearables on the day to day so I think, you know, 90 00:04:54,320 --> 00:04:57,400 Speaker 2: they're all generally good, some better than others. Apple Watch 91 00:04:57,480 --> 00:04:59,360 Speaker 2: is great for a normal human just you know, doing 92 00:04:59,360 --> 00:05:01,200 Speaker 2: the day to day. So it really just depends on 93 00:05:01,240 --> 00:05:02,560 Speaker 2: you know, what your applications are. 94 00:05:03,000 --> 00:05:07,120 Speaker 3: Yeah, it's interesting because recently, I so I've been I've 95 00:05:07,120 --> 00:05:08,919 Speaker 3: been wearing an Apple Watch for a number of years, and 96 00:05:08,960 --> 00:05:11,640 Speaker 3: then recently I was also worrying a garment because of 97 00:05:11,680 --> 00:05:14,400 Speaker 3: an intervention we're doing with the military guys over here 98 00:05:14,560 --> 00:05:18,719 Speaker 3: who all have Garman watches and and and the HRV 99 00:05:19,279 --> 00:05:22,600 Speaker 3: is is a little bit different on both of those devices, right, 100 00:05:22,920 --> 00:05:26,599 Speaker 3: And I think this is what people don't understand is 101 00:05:26,640 --> 00:05:32,520 Speaker 3: that whilst they're all reasonably accurate, they do vary, right, 102 00:05:33,160 --> 00:05:37,120 Speaker 3: And that my understanding is that Garman is probably a 103 00:05:37,120 --> 00:05:39,440 Speaker 3: bit more accurate when it comes to HRV because I 104 00:05:39,520 --> 00:05:41,960 Speaker 3: think they bought first Beat a number of years ago, 105 00:05:42,520 --> 00:05:46,839 Speaker 3: and Apple uses a slightly different measurement technique. I think 106 00:05:46,839 --> 00:05:48,280 Speaker 3: most of them use our MSSD. 107 00:05:48,680 --> 00:05:49,120 Speaker 1: Right, So. 108 00:05:51,480 --> 00:05:55,760 Speaker 3: You have you have to you can't go from device 109 00:05:55,839 --> 00:06:00,560 Speaker 3: to device in order for tracking your trends accurate, right. 110 00:06:00,880 --> 00:06:03,080 Speaker 2: Yeah, as long as you stick with one one device 111 00:06:03,120 --> 00:06:05,640 Speaker 2: and you look at the trends holistically, you'll be fine, right, 112 00:06:05,720 --> 00:06:08,479 Speaker 2: I mean, ninety five percent of humans would be fine. 113 00:06:09,000 --> 00:06:12,640 Speaker 2: You know, there is there's no standard algorithm for HRV measurement, 114 00:06:12,880 --> 00:06:16,000 Speaker 2: you know, so again it absolutely varies between different devices. 115 00:06:16,000 --> 00:06:19,240 Speaker 2: We actually got IRB approval to do a research study 116 00:06:19,240 --> 00:06:22,279 Speaker 2: on exactly that, so looking at the variants of HRV. 117 00:06:22,720 --> 00:06:25,440 Speaker 2: And then to your point, the the Apple Watch is 118 00:06:25,520 --> 00:06:29,160 Speaker 2: also it's a different definition, it's not rms SD and 119 00:06:29,200 --> 00:06:33,599 Speaker 2: then they also I think sample so you know, honestly, 120 00:06:33,640 --> 00:06:35,640 Speaker 2: I think Apple Watch is one of the less accurate 121 00:06:35,680 --> 00:06:37,280 Speaker 2: of all of them. But you know, again it's good 122 00:06:37,360 --> 00:06:39,880 Speaker 2: for the normal US and human for you know, just 123 00:06:39,960 --> 00:06:41,560 Speaker 2: the typical trends. 124 00:06:41,839 --> 00:06:44,960 Speaker 3: Yeah, well that's the thing, isn't it. It's more the 125 00:06:45,200 --> 00:06:48,200 Speaker 3: trend over time rather than the absolute number. 126 00:06:48,240 --> 00:06:48,800 Speaker 1: With this sort of. 127 00:06:48,880 --> 00:06:52,279 Speaker 2: Number doesn't really matter, you know, I mean, it's important, 128 00:06:52,279 --> 00:06:53,440 Speaker 2: but yeah, it's all relative. 129 00:06:53,600 --> 00:06:58,400 Speaker 3: So yeah, last year numbers consistently in the no chains 130 00:06:58,520 --> 00:06:59,360 Speaker 3: or something like that. 131 00:07:00,400 --> 00:07:01,599 Speaker 2: What is what is your HRV? 132 00:07:02,040 --> 00:07:06,240 Speaker 3: You know on an Apple Watch it kicks around fifty, 133 00:07:06,560 --> 00:07:08,240 Speaker 3: sort of bounces around that. 134 00:07:08,240 --> 00:07:11,080 Speaker 1: Number a little bit lower on a garment, right. 135 00:07:11,000 --> 00:07:15,240 Speaker 3: Which is which was interesting. But the garment also told 136 00:07:15,240 --> 00:07:18,080 Speaker 3: me that it once three weeks of data before it 137 00:07:18,240 --> 00:07:22,400 Speaker 3: really gets accurate. And I quite like that, right, I'm like, yeah, 138 00:07:22,520 --> 00:07:23,960 Speaker 3: okay to celebrate. 139 00:07:25,600 --> 00:07:26,800 Speaker 1: Yeah, no, very cool. 140 00:07:27,000 --> 00:07:29,960 Speaker 3: So the guy have a There's a research people that 141 00:07:30,000 --> 00:07:34,400 Speaker 3: I often talk about when I'm presenting to Comforts, and 142 00:07:34,640 --> 00:07:39,360 Speaker 3: it's the the similarities between overtraining syndrome. 143 00:07:39,080 --> 00:07:41,240 Speaker 1: In athletes and corporate burnout. 144 00:07:41,680 --> 00:07:45,920 Speaker 3: Right, So, and I often talk about this type upe 145 00:07:46,200 --> 00:07:50,040 Speaker 3: that people walk, whether there are an elite athlete or 146 00:07:50,480 --> 00:07:55,720 Speaker 3: a corporate there's this very thin line between ultimate peak 147 00:07:55,720 --> 00:07:58,520 Speaker 3: performance on one side of the line and then on 148 00:07:58,560 --> 00:08:01,920 Speaker 3: the other side of the line over training syndrome or burnout. 149 00:08:02,560 --> 00:08:05,440 Speaker 1: And I know that you play in this space. 150 00:08:05,640 --> 00:08:10,680 Speaker 3: So how could people balance whether they're an athlete or 151 00:08:10,720 --> 00:08:14,480 Speaker 3: whether they are a corporate How do they make sure 152 00:08:14,600 --> 00:08:17,640 Speaker 3: that they stay on the right side of that type rope? 153 00:08:18,160 --> 00:08:20,960 Speaker 2: Yeah, one hundred percent. I mean I would. I'd love 154 00:08:20,960 --> 00:08:23,880 Speaker 2: to read the paper you're referencing, but I would. I 155 00:08:23,880 --> 00:08:29,040 Speaker 2: would assume that recovery and autonomic regulation is identical part 156 00:08:29,040 --> 00:08:30,720 Speaker 2: of that, right, And we were just talking about HRV 157 00:08:30,880 --> 00:08:34,960 Speaker 2: as an example, so you know, I would assume that 158 00:08:35,000 --> 00:08:37,079 Speaker 2: there would be a connection, you know, between those two, 159 00:08:37,120 --> 00:08:40,599 Speaker 2: whether it's you know, overtraining or corporate burnout. So recovery. 160 00:08:40,720 --> 00:08:43,840 Speaker 2: You know, everyone's looking for this longevity cure. You know, 161 00:08:43,920 --> 00:08:46,199 Speaker 2: what do you do to stay young? And they want 162 00:08:46,240 --> 00:08:48,720 Speaker 2: to do a pill and peptides and stem cells. And 163 00:08:49,160 --> 00:08:51,840 Speaker 2: it starts with sleep. You know, if you're getting quality 164 00:08:51,880 --> 00:08:54,520 Speaker 2: sleep that you can ideally measure, you don't have to, 165 00:08:54,880 --> 00:08:56,880 Speaker 2: you know, but again I'm a big fan of measurement 166 00:08:56,880 --> 00:09:00,160 Speaker 2: because it allows you to then optimize. But that's it. Know, 167 00:09:00,360 --> 00:09:03,640 Speaker 2: you really start with sleep. And so from that perspective again, 168 00:09:03,840 --> 00:09:07,120 Speaker 2: autonomic you know, HRV resting heart rate, you know, it's 169 00:09:07,200 --> 00:09:11,200 Speaker 2: kind of the inverse correlation. Yeah, all critically. 170 00:09:10,800 --> 00:09:15,840 Speaker 3: Important and and and athletes years ago, before HRV measurement 171 00:09:16,000 --> 00:09:20,600 Speaker 3: became a thing, athletes used to measure their waking heart 172 00:09:20,679 --> 00:09:23,080 Speaker 3: rate as soon as they woke up, right, and if 173 00:09:23,120 --> 00:09:26,040 Speaker 3: they're for resting it, yeah, for resting heart rate and 174 00:09:26,120 --> 00:09:31,240 Speaker 3: if they're they're waking, resting heart rate had gone either up. 175 00:09:31,160 --> 00:09:34,640 Speaker 1: Or down by three or four beats. That was a sign. 176 00:09:34,760 --> 00:09:36,520 Speaker 1: You know, that was the early. 177 00:09:36,440 --> 00:09:44,160 Speaker 3: Indicator of the the current HRV status. Right, And I 178 00:09:43,160 --> 00:09:47,319 Speaker 3: am I completely align with you in terms of recovery. 179 00:09:47,400 --> 00:09:50,800 Speaker 3: I mean, when we think about an athlete, and you know, 180 00:09:50,880 --> 00:09:58,679 Speaker 3: they're constantly manipulating or their their their trainers are manipulating volume, intensity, duration, 181 00:09:59,360 --> 00:10:01,719 Speaker 3: and and you know, one of the key things of 182 00:10:02,040 --> 00:10:06,280 Speaker 3: athlete training is you do not increase volume and intensity 183 00:10:06,360 --> 00:10:09,440 Speaker 3: for a long period of time or you're heading towards burnout. 184 00:10:09,679 --> 00:10:12,640 Speaker 1: Right, So they'll manipulate all those variables. 185 00:10:12,679 --> 00:10:16,559 Speaker 3: But I think for the corporate who's listening to us, 186 00:10:16,960 --> 00:10:20,440 Speaker 3: they're not really in control of volume and intensity. 187 00:10:20,480 --> 00:10:20,640 Speaker 2: You know. 188 00:10:20,760 --> 00:10:23,599 Speaker 3: Sometimes they're just in a heavy period at work. And 189 00:10:23,920 --> 00:10:26,680 Speaker 3: as I say to them, the one lever that you 190 00:10:26,800 --> 00:10:28,520 Speaker 3: have to pull is recovery. 191 00:10:29,679 --> 00:10:32,200 Speaker 1: If you're a corporate, right, I think you'd be honored with. 192 00:10:32,080 --> 00:10:34,439 Speaker 2: That hundred percent. Yeah, you know, and some of the 193 00:10:34,480 --> 00:10:36,200 Speaker 2: stuff I mean again, I'm a big fan of like 194 00:10:36,280 --> 00:10:40,400 Speaker 2: cold plunging for autonomic relations. Yes, here in Colorado we 195 00:10:40,440 --> 00:10:42,400 Speaker 2: go in the rivers right now, all the snows starting 196 00:10:42,440 --> 00:10:46,560 Speaker 2: to melt, so they're pretty chilly, probably you know, high 197 00:10:46,600 --> 00:10:50,720 Speaker 2: thirties or so, you know, depending and but yeah, I 198 00:10:50,760 --> 00:10:53,319 Speaker 2: mean like that as an example. Breathwork would be another. 199 00:10:53,960 --> 00:10:56,360 Speaker 2: So we call these micro habits in our world. You know, 200 00:10:56,440 --> 00:10:59,680 Speaker 2: microrabits build a protocol, and so there are protocols to 201 00:10:59,720 --> 00:11:02,280 Speaker 2: help with recovery. Those protocols to help with anxiety, I 202 00:11:02,320 --> 00:11:04,560 Speaker 2: mean that's another one just stress in general. You know, 203 00:11:04,600 --> 00:11:07,320 Speaker 2: what are you doing to manage the stress? Of course 204 00:11:07,360 --> 00:11:11,080 Speaker 2: the two are obviously connected. So and then for there, 205 00:11:11,160 --> 00:11:12,719 Speaker 2: you know, what are you putting into your body, what's 206 00:11:12,760 --> 00:11:16,320 Speaker 2: your you know, your nutritional regimen, what's your exercise regimen, 207 00:11:17,080 --> 00:11:20,320 Speaker 2: all those pieces, and I find you know, when I 208 00:11:20,320 --> 00:11:21,880 Speaker 2: was iron main training, we used to do what are 209 00:11:21,920 --> 00:11:24,439 Speaker 2: called bricks, you know, and essentially like move your training 210 00:11:24,520 --> 00:11:27,160 Speaker 2: up and then two to three weeks before the race, 211 00:11:27,200 --> 00:11:28,920 Speaker 2: depending on the distance, you know, you would start to 212 00:11:28,960 --> 00:11:32,040 Speaker 2: taper yea to really fortify your muscles and then do 213 00:11:32,080 --> 00:11:34,800 Speaker 2: the race, you know. So there's different strategies there. That 214 00:11:34,840 --> 00:11:35,600 Speaker 2: makes a lot of sense. 215 00:11:36,160 --> 00:11:39,959 Speaker 3: Yeah, And I like to talk to people about micro 216 00:11:40,160 --> 00:11:42,480 Speaker 3: and macro recovery, which. 217 00:11:42,280 --> 00:11:44,600 Speaker 1: You've essentially you've essentially mentioned, right, So. 218 00:11:44,600 --> 00:11:48,719 Speaker 3: Your macro recovery is your sleep, and your micro recovery 219 00:11:49,160 --> 00:11:52,040 Speaker 3: are little bits of recovery you can do throughout the day, 220 00:11:52,280 --> 00:11:55,840 Speaker 3: like just a little bit of get off your arson, move, 221 00:11:56,000 --> 00:11:59,960 Speaker 3: drink some water, do some do some slow controlled breathe. 222 00:12:01,320 --> 00:12:04,760 Speaker 3: That that autonomic regulation. So a lot of people don't 223 00:12:04,760 --> 00:12:08,520 Speaker 3: realize like one of the most powerful ways to switch 224 00:12:08,559 --> 00:12:12,000 Speaker 3: on your parasympathetic nervous system and dampen your sympathetic nervous 225 00:12:12,000 --> 00:12:17,920 Speaker 3: system is through the breath. Do you have a fevered 226 00:12:18,280 --> 00:12:22,440 Speaker 3: recovery breathing protocol, because there's lots of different ones. 227 00:12:22,520 --> 00:12:23,559 Speaker 1: Is there anything? 228 00:12:23,640 --> 00:12:26,920 Speaker 2: No, But I mean I've done so many different kinds, 229 00:12:26,920 --> 00:12:30,079 Speaker 2: from yoga, nidra to box breathing, you know, everything in between. 230 00:12:30,200 --> 00:12:33,040 Speaker 2: But if you have a protocol, we'd love to take 231 00:12:33,080 --> 00:12:34,600 Speaker 2: a look and we can put it on the platform 232 00:12:34,800 --> 00:12:36,600 Speaker 2: and have people you know, ultimately use it. 233 00:12:36,840 --> 00:12:39,880 Speaker 3: So yeah, yeah, Look, I mean I generally say to 234 00:12:39,920 --> 00:12:43,280 Speaker 3: people any type of slow control breathing is going to 235 00:12:43,400 --> 00:12:47,520 Speaker 3: switch on your vegas nerve from the bottom up. I 236 00:12:47,559 --> 00:12:52,680 Speaker 3: have personally have a slight bent for resonant frequency breathing 237 00:12:52,720 --> 00:12:55,920 Speaker 3: because the research shows that that can affect your heart 238 00:12:56,000 --> 00:12:59,680 Speaker 3: rate variability more than others. But I think I think 239 00:12:59,679 --> 00:13:03,880 Speaker 3: they e is just to slow down the breath. And 240 00:13:03,960 --> 00:13:08,080 Speaker 3: another really good protocol that people can use. Actually, my 241 00:13:08,120 --> 00:13:11,680 Speaker 3: PhD supervisor had told me this one is the your 242 00:13:11,800 --> 00:13:16,400 Speaker 3: lowest comfortable breathing rate where people can try, where you 243 00:13:16,400 --> 00:13:18,880 Speaker 3: you just take a normal breath in and then you 244 00:13:19,000 --> 00:13:23,040 Speaker 3: breathe out through per slips as slow as you possibly 245 00:13:23,160 --> 00:13:27,680 Speaker 3: can and squeeze everything out of your diaphragm. But what 246 00:13:27,840 --> 00:13:31,760 Speaker 3: comes really interesting is at the end of that the inhalation, 247 00:13:32,679 --> 00:13:36,480 Speaker 3: you don't have to actively inhaliate because your lungs will 248 00:13:36,640 --> 00:13:40,040 Speaker 3: just fill up automatically because of the pressure vacuum that 249 00:13:40,120 --> 00:13:40,760 Speaker 3: you've created. 250 00:13:40,880 --> 00:13:42,680 Speaker 1: And it's really quite interesting. 251 00:13:42,840 --> 00:13:47,200 Speaker 3: But yeah, I highly recommend that people play with a 252 00:13:47,400 --> 00:13:50,680 Speaker 3: number of different things in terms of recovery, because as 253 00:13:50,679 --> 00:13:54,040 Speaker 3: you as you rightly said eighties, it's the one thing 254 00:13:54,520 --> 00:13:57,760 Speaker 3: that's going to determine what side of that type rope 255 00:13:57,760 --> 00:14:01,839 Speaker 3: that you actually are on them. What what are some 256 00:14:02,520 --> 00:14:07,880 Speaker 3: early warning signs and symptoms that people would see in 257 00:14:08,320 --> 00:14:12,520 Speaker 3: their own data or feel that would suggest that A 258 00:14:12,760 --> 00:14:15,720 Speaker 3: there are an athlete that's overtraining or b there corporate 259 00:14:15,800 --> 00:14:19,080 Speaker 3: that's starting to get on the wrong side of the 260 00:14:19,120 --> 00:14:19,600 Speaker 3: type rope. 261 00:14:20,320 --> 00:14:22,440 Speaker 2: Yeah, one hundred percent. Honestly, I think it's the ones 262 00:14:22,480 --> 00:14:25,880 Speaker 2: we already mentioned, you know, HRV, resting heart rate. I mean, 263 00:14:25,920 --> 00:14:28,840 Speaker 2: I look at HRV, the two of them, really but 264 00:14:28,920 --> 00:14:31,560 Speaker 2: those are my go to and I know, you know, 265 00:14:31,560 --> 00:14:33,640 Speaker 2: if I'm on the high side, I'm in my HV 266 00:14:33,720 --> 00:14:36,040 Speaker 2: can be a size one hundred. I'd say average about 267 00:14:36,080 --> 00:14:39,440 Speaker 2: sixty to seventy with a whoop. And you know, I 268 00:14:39,480 --> 00:14:43,040 Speaker 2: know if I am really overtraining overtired, it's in like 269 00:14:43,080 --> 00:14:46,440 Speaker 2: the thirties. So you know, HRV for me is and 270 00:14:46,480 --> 00:14:48,880 Speaker 2: of course you have again resting heart rate is almost 271 00:14:48,880 --> 00:14:49,880 Speaker 2: like an inverse correlation. 272 00:14:50,720 --> 00:14:50,880 Speaker 1: Yea. 273 00:14:51,280 --> 00:14:53,760 Speaker 2: So those are the two that I go to. You know, 274 00:14:53,800 --> 00:14:55,880 Speaker 2: there's also sleep scores you can get out of the 275 00:14:56,000 --> 00:14:59,520 Speaker 2: or ring or readiness is what they call it. You know, 276 00:14:59,600 --> 00:15:01,920 Speaker 2: both of those are great. It gives you an example 277 00:15:02,040 --> 00:15:05,520 Speaker 2: or a you know, a specific number relative to your 278 00:15:05,560 --> 00:15:08,640 Speaker 2: sleep and how you can improve in similar with just 279 00:15:08,680 --> 00:15:11,120 Speaker 2: your daily readiness. So I think those are all great 280 00:15:11,160 --> 00:15:11,920 Speaker 2: metrics to use. 281 00:15:12,600 --> 00:15:17,000 Speaker 3: Yeah, the ones that they frustrate me a little bit 282 00:15:17,200 --> 00:15:19,920 Speaker 3: as a as a researcher. So when we were looking 283 00:15:19,960 --> 00:15:23,640 Speaker 3: at doing this this intervention we're doing with the military currently, 284 00:15:24,200 --> 00:15:27,160 Speaker 3: you know, we were looking at the different devices and 285 00:15:27,840 --> 00:15:31,640 Speaker 3: looking at HRV and wanting to get the raw data 286 00:15:32,080 --> 00:15:34,400 Speaker 3: right and a lot of them won't share the raw data. 287 00:15:34,520 --> 00:15:37,160 Speaker 3: You know, they'll they'll give you a they'll give you 288 00:15:37,200 --> 00:15:40,480 Speaker 3: a score or a body battery or a readiness score 289 00:15:41,000 --> 00:15:44,240 Speaker 3: where they don't publish the algorithm, and I get why 290 00:15:44,240 --> 00:15:47,520 Speaker 3: they don't because that's their IP, right, and it's probably 291 00:15:48,520 --> 00:15:52,640 Speaker 3: some combination of your sleep and your HRV that they're 292 00:15:52,840 --> 00:15:57,240 Speaker 3: they're integrating to give you your readiness score. Right, just 293 00:15:57,240 --> 00:16:01,160 Speaker 3: just my my annoyance as a researchers they don't give 294 00:16:01,160 --> 00:16:04,920 Speaker 3: you the algorithm so that you can then really accurately 295 00:16:05,000 --> 00:16:08,120 Speaker 3: work out our people are trending. But but I guess 296 00:16:08,120 --> 00:16:10,640 Speaker 3: for the individual, it doesn't really matter, right, So. 297 00:16:11,240 --> 00:16:13,520 Speaker 2: Yeah, exactly for the individual doesn't matter. But actually we 298 00:16:13,600 --> 00:16:15,480 Speaker 2: might have a partner I could recommend to you who 299 00:16:15,560 --> 00:16:18,320 Speaker 2: can support you their you know, relative to the HRV measurement. 300 00:16:18,680 --> 00:16:20,760 Speaker 2: One of our partners, I mean they actually measure each 301 00:16:20,840 --> 00:16:23,200 Speaker 2: of you through four different modalities, you know when they're 302 00:16:23,200 --> 00:16:25,400 Speaker 2: doing a session. It's a group that we work. 303 00:16:25,200 --> 00:16:25,840 Speaker 1: At out of LA. 304 00:16:26,680 --> 00:16:29,120 Speaker 2: So yeah, but happy to chat and it might have 305 00:16:29,240 --> 00:16:30,080 Speaker 2: someone for you there. 306 00:16:30,480 --> 00:16:31,400 Speaker 1: Yeah, okay, cool. 307 00:16:31,720 --> 00:16:36,360 Speaker 3: And so you talk about similar to me, You talk 308 00:16:36,520 --> 00:16:39,600 Speaker 3: that that the next frontier is not just lifespan, right, 309 00:16:39,640 --> 00:16:43,920 Speaker 3: life span is one thing, but health span and mind 310 00:16:44,000 --> 00:16:48,320 Speaker 3: span or other things. So quickly, I mean most people 311 00:16:48,360 --> 00:16:53,840 Speaker 3: will be familiar between health span and lifespan, but but 312 00:16:54,080 --> 00:16:57,480 Speaker 3: just to give the definition or the differentiation between those 313 00:16:57,520 --> 00:17:00,280 Speaker 3: and also this idea of mind span a lot of 314 00:17:00,280 --> 00:17:01,880 Speaker 3: people won't be familiar with. 315 00:17:02,280 --> 00:17:06,159 Speaker 2: Yep, so lifespan. You know, basically, if you were to 316 00:17:06,359 --> 00:17:08,600 Speaker 2: look at a graph, it's like, what is the quality 317 00:17:08,640 --> 00:17:13,240 Speaker 2: of your life through really the later you know stages essentially, 318 00:17:13,440 --> 00:17:15,840 Speaker 2: and then you know, relative to that quality of life, 319 00:17:15,840 --> 00:17:18,960 Speaker 2: can you improve that? Essentially? So if you look at 320 00:17:19,000 --> 00:17:22,119 Speaker 2: your life, you know, people really start slowing down in 321 00:17:22,119 --> 00:17:25,600 Speaker 2: your seventies and eighties, you know, can you basically normalize 322 00:17:25,680 --> 00:17:29,480 Speaker 2: and have a better you know life quality of life? 323 00:17:29,520 --> 00:17:31,480 Speaker 2: I come back to, you know, in those later later 324 00:17:31,520 --> 00:17:35,720 Speaker 2: periods basically, so you're extending those last years. I think 325 00:17:35,720 --> 00:17:41,600 Speaker 2: of mind span as a reflection of your This is 326 00:17:41,600 --> 00:17:44,360 Speaker 2: my personal definition. But you know, I would almost throw 327 00:17:44,400 --> 00:17:48,560 Speaker 2: in consciousness as well as brain and cognition. You know, 328 00:17:48,600 --> 00:17:50,520 Speaker 2: generally we spend a lot of time just thinking about 329 00:17:50,560 --> 00:17:53,560 Speaker 2: brain optimization, but you know consciousness as part of that 330 00:17:53,600 --> 00:17:57,119 Speaker 2: as well. That could include spirituality, conclude connection, you know, 331 00:17:57,160 --> 00:18:00,119 Speaker 2: any of those pieces. So that's also been in there 332 00:18:00,320 --> 00:18:01,760 Speaker 2: of my research over the years. 333 00:18:02,200 --> 00:18:08,040 Speaker 3: Yeah, cool, and Hi is ai either helping in this 334 00:18:08,160 --> 00:18:11,879 Speaker 3: area or helping to ship some of the thinking in 335 00:18:11,920 --> 00:18:12,479 Speaker 3: this area. 336 00:18:13,240 --> 00:18:16,080 Speaker 2: Yeah, I mean, I think there's positives and negatives of everything. 337 00:18:16,200 --> 00:18:19,320 Speaker 2: You know, it's a spectrum, So I believe there are 338 00:18:19,400 --> 00:18:23,520 Speaker 2: some very strong positives. An example right now is one 339 00:18:23,520 --> 00:18:28,000 Speaker 2: of our lead scientists. His name's doctor Galen Buckwalter. Galen 340 00:18:28,119 --> 00:18:30,880 Speaker 2: had a tragic accident when he was seventeen, jumped off 341 00:18:30,880 --> 00:18:34,399 Speaker 2: a bridge, hit a rock, and is a quadriplegic. And 342 00:18:35,240 --> 00:18:38,800 Speaker 2: he has he qualified for a clinical trial at Caltech 343 00:18:38,840 --> 00:18:42,080 Speaker 2: and he has six neural implants in his brain, and 344 00:18:42,160 --> 00:18:44,280 Speaker 2: so I've been with him at cal Tech before. It's 345 00:18:44,280 --> 00:18:47,199 Speaker 2: an amazing clinical trial. He comes in and they screw 346 00:18:47,280 --> 00:18:52,960 Speaker 2: on essentially these they're called peds essentially interfaces onto his skull, 347 00:18:53,240 --> 00:18:55,399 Speaker 2: and then they connect his brain to the Internet. And 348 00:18:55,440 --> 00:18:57,959 Speaker 2: so we are the generation that's seeing the intersection of 349 00:18:58,480 --> 00:19:02,680 Speaker 2: biology and machines right now. And so in that example, 350 00:19:02,880 --> 00:19:05,240 Speaker 2: you know, the AI is helping Galen to control a 351 00:19:05,320 --> 00:19:09,520 Speaker 2: robotic arm and ultimately free him, you know, to some degree. 352 00:19:09,800 --> 00:19:13,800 Speaker 2: So that's called brain computer interfaces. There's also spinal cord 353 00:19:14,080 --> 00:19:16,840 Speaker 2: essentially interfaces where they're going directly into the spinal cord, 354 00:19:16,880 --> 00:19:19,480 Speaker 2: you know, for people who have these tragic injuries and accidents. 355 00:19:19,520 --> 00:19:23,720 Speaker 2: So I think those are very positive applications of AI. 356 00:19:24,800 --> 00:19:26,840 Speaker 2: There's also negative ones as well. You know, you see 357 00:19:26,840 --> 00:19:29,720 Speaker 2: in the workplace, I mean everyone is basically just using 358 00:19:29,760 --> 00:19:33,000 Speaker 2: an LLM to not think yeah, and so I think 359 00:19:33,000 --> 00:19:35,320 Speaker 2: that can very much be to the detriment of the 360 00:19:35,400 --> 00:19:39,280 Speaker 2: human But you know what we found is really it's 361 00:19:39,359 --> 00:19:41,399 Speaker 2: human in the loop. You know that concept like you 362 00:19:41,440 --> 00:19:44,680 Speaker 2: should absolutely utilize the AI, but you can't trust it. 363 00:19:44,760 --> 00:19:48,040 Speaker 2: You know, it's not there yet. And especially you know 364 00:19:48,080 --> 00:19:50,439 Speaker 2: in our world, Paul, I mean we have many uh 365 00:19:50,720 --> 00:19:52,479 Speaker 2: you know clients, you know, we hear about this all 366 00:19:52,520 --> 00:19:55,160 Speaker 2: the time where they're just taking all of their medical 367 00:19:55,359 --> 00:19:58,320 Speaker 2: information and just uploading it to chat GPT. And the 368 00:19:58,440 --> 00:20:02,560 Speaker 2: question is why, Well, in the United States are you know, 369 00:20:02,560 --> 00:20:05,120 Speaker 2: our our physicians are not taught nutrition. You know, they're 370 00:20:05,119 --> 00:20:06,760 Speaker 2: taught maybe three or four days I think out of 371 00:20:06,800 --> 00:20:09,040 Speaker 2: their entire tenure. 372 00:20:09,680 --> 00:20:10,959 Speaker 1: It's pretty much the same over here. 373 00:20:10,960 --> 00:20:13,560 Speaker 3: I think they get about a week's education or nutri 374 00:20:13,840 --> 00:20:17,000 Speaker 3: Do not go and see a doctor with for nutritional advice. 375 00:20:17,080 --> 00:20:20,000 Speaker 2: Right of course? Right well there, and that's that's that's 376 00:20:20,119 --> 00:20:23,080 Speaker 2: kind of insane, right. I have this quick anecdote. I 377 00:20:23,119 --> 00:20:26,240 Speaker 2: broke my collarbone here in Colorado, and I went to 378 00:20:26,240 --> 00:20:29,320 Speaker 2: the number one orthopedic in the country and I was like, 379 00:20:29,359 --> 00:20:31,359 Speaker 2: what's you know. She's like, it's broken. I was like, okay, 380 00:20:31,359 --> 00:20:33,560 Speaker 2: what's my recovery protocol? And she threw me a sling 381 00:20:33,680 --> 00:20:36,520 Speaker 2: and so my recovery protocol was a mobilization. And then 382 00:20:36,520 --> 00:20:38,679 Speaker 2: I went to my network and I was focusing on nutrition, 383 00:20:38,880 --> 00:20:42,280 Speaker 2: bone broth, collagen. I did some pemp PMF if you're 384 00:20:42,320 --> 00:20:47,119 Speaker 2: familiar with that modality, localized electrical stimulation basically, and I 385 00:20:47,160 --> 00:20:49,320 Speaker 2: went back and she said come back in four weeks. 386 00:20:49,320 --> 00:20:51,080 Speaker 2: I went back. I'm sorry, she said come back in six. 387 00:20:51,119 --> 00:20:53,639 Speaker 2: I went back and forth and she did the X 388 00:20:53,720 --> 00:20:55,679 Speaker 2: ray and she's like, oh my gosh, it's completely healed. 389 00:20:55,720 --> 00:20:57,240 Speaker 2: What have you been doing? And I was like, doctor, 390 00:20:57,240 --> 00:20:59,679 Speaker 2: I've been focusing on my nutrition and she's like, we 391 00:20:59,720 --> 00:21:01,199 Speaker 2: never would have thought of that. And it was one 392 00:21:01,240 --> 00:21:02,960 Speaker 2: of those moments. Paul. It's like when I started my 393 00:21:03,000 --> 00:21:04,240 Speaker 2: company is like, okay, we have. 394 00:21:04,240 --> 00:21:04,720 Speaker 1: To do better. 395 00:21:04,880 --> 00:21:07,600 Speaker 2: Like if your doctor is not thinking about nutrition, there's 396 00:21:07,640 --> 00:21:09,240 Speaker 2: an issue, you know, we have to think of the 397 00:21:09,240 --> 00:21:12,439 Speaker 2: whole human. Another example, my backgroun's in molecular biology. I 398 00:21:12,440 --> 00:21:14,720 Speaker 2: didn't really cover that. But I spent many years in 399 00:21:14,760 --> 00:21:17,920 Speaker 2: the lab as a molecular biologist, and you know, from 400 00:21:17,960 --> 00:21:21,840 Speaker 2: that perspective, you know they're not taught genomics, you know, 401 00:21:21,920 --> 00:21:26,040 Speaker 2: let alone epigenomics, let alone peptide. So you know, it's 402 00:21:26,359 --> 00:21:29,560 Speaker 2: it's this fairly terrifying trend. People are now just going 403 00:21:29,600 --> 00:21:31,680 Speaker 2: to the ms and uploading everything because they can't find 404 00:21:31,760 --> 00:21:34,840 Speaker 2: what they need from their doctors today. So you know, 405 00:21:34,920 --> 00:21:37,080 Speaker 2: I again, I try to be an optimist on that front, 406 00:21:37,119 --> 00:21:39,320 Speaker 2: and that's why we're you know, putting some confines around 407 00:21:39,359 --> 00:21:42,000 Speaker 2: what we're building. But it's a it's a challenge. 408 00:21:42,680 --> 00:21:46,560 Speaker 3: It's interesting you mentioned that that whole recovery pace. So 409 00:21:46,560 --> 00:21:50,200 Speaker 3: so last year, in January last year, I had open 410 00:21:50,280 --> 00:21:55,960 Speaker 3: heart surgery because I find out by chance that I 411 00:21:56,000 --> 00:21:59,200 Speaker 3: had a congenital heart defect. I had a bicuspo of 412 00:21:59,280 --> 00:22:01,280 Speaker 3: a ORTI file rather than try customers. 413 00:22:01,280 --> 00:22:04,520 Speaker 1: But but anyway, I ended up having open heart surgery 414 00:22:04,760 --> 00:22:06,360 Speaker 1: and I wanted. 415 00:22:06,119 --> 00:22:08,520 Speaker 3: To get out of that hospital as quick as I 416 00:22:08,640 --> 00:22:14,000 Speaker 3: possibly could because number one, the food was shit right 417 00:22:14,119 --> 00:22:17,800 Speaker 3: that it was so such low protein. And I know 418 00:22:17,880 --> 00:22:20,440 Speaker 3: that if you just had your chest cut open and 419 00:22:20,560 --> 00:22:24,520 Speaker 3: cut through bone, you need you need amino acids big time. 420 00:22:24,600 --> 00:22:27,320 Speaker 3: You need collagen, you need all of those things you need. 421 00:22:27,600 --> 00:22:30,159 Speaker 3: You need to be looking at the window at nature, 422 00:22:30,200 --> 00:22:32,240 Speaker 3: I was looking at at a brick wall. I'm like, 423 00:22:32,520 --> 00:22:37,280 Speaker 3: this place is shocking for my recovery. But I also 424 00:22:37,600 --> 00:22:41,200 Speaker 3: I used bone broths a lot, I had a lot 425 00:22:41,200 --> 00:22:43,440 Speaker 3: of protein, and I used red light and near in 426 00:22:43,560 --> 00:22:48,000 Speaker 3: for real light on the wound, which which was freaking awesome. 427 00:22:48,080 --> 00:22:50,560 Speaker 1: That like how quickly that wound healed. 428 00:22:50,560 --> 00:22:54,240 Speaker 3: And now they actually use you know, real light is 429 00:22:54,280 --> 00:22:57,800 Speaker 3: a standard protocol for burns victim for a very good reason, right. 430 00:22:58,240 --> 00:23:01,440 Speaker 3: And the and the near infra red stimulates your microchondria. 431 00:23:01,520 --> 00:23:04,440 Speaker 3: So there's there's so much stuff that we can do 432 00:23:04,760 --> 00:23:08,960 Speaker 3: in terms of recovery that is just not in the 433 00:23:08,960 --> 00:23:13,040 Speaker 3: healthcare system. And I think the reason for it is 434 00:23:13,600 --> 00:23:16,320 Speaker 3: the healthcare system is really the healthcare system. It's the 435 00:23:16,480 --> 00:23:21,480 Speaker 3: sick curse system, right. It is just interested in can 436 00:23:21,520 --> 00:23:25,520 Speaker 3: we stop or cure this disease and then once we do, boom, 437 00:23:25,600 --> 00:23:30,000 Speaker 3: you're good or fix this thing and then that recovery. 438 00:23:30,160 --> 00:23:34,840 Speaker 3: They are not interested in recovery and optimal health whatsoever. Right, 439 00:23:34,880 --> 00:23:37,679 Speaker 3: So I think it's important for people to understand that 440 00:23:37,840 --> 00:23:39,240 Speaker 3: different or prevention. 441 00:23:39,600 --> 00:23:42,960 Speaker 2: You know, yes, yeah, that's the doctors we work with. 442 00:23:43,560 --> 00:23:45,200 Speaker 2: You know, they're really focused on how do you prevent 443 00:23:45,240 --> 00:23:47,879 Speaker 2: the disease? You know, even gets to the point it's 444 00:23:47,920 --> 00:23:51,840 Speaker 2: an actual disease. Sometimes you can, of course, but you know, 445 00:23:51,920 --> 00:23:54,520 Speaker 2: I think starting there, we're big fans, so we of 446 00:23:54,520 --> 00:23:58,280 Speaker 2: course look at the biomarkers in biometrics, but now pulling 447 00:23:58,320 --> 00:24:00,520 Speaker 2: in you know, the epigenetic data as well well, and 448 00:24:00,600 --> 00:24:02,560 Speaker 2: you can really build this profile of a human and 449 00:24:02,600 --> 00:24:06,080 Speaker 2: really understand you know, their genetic predisposition all around to 450 00:24:06,119 --> 00:24:09,399 Speaker 2: their gene expression and how does that ultimately impact you know, 451 00:24:09,400 --> 00:24:13,119 Speaker 2: their day to day you know. Fascinating fact is, you 452 00:24:13,160 --> 00:24:16,960 Speaker 2: know we control through our behavior and our lifestyle, and 453 00:24:17,040 --> 00:24:18,800 Speaker 2: it depends on the tissue. And it's you know, it's 454 00:24:18,800 --> 00:24:20,399 Speaker 2: a little bit of a controversial number, but you know, 455 00:24:20,480 --> 00:24:22,880 Speaker 2: maybe thirty to fifty sixty percent of our gene expression 456 00:24:22,960 --> 00:24:25,280 Speaker 2: is based on our behavior. It's based on the people 457 00:24:25,280 --> 00:24:28,240 Speaker 2: you surround yourself with. It's based on the conversations, you know, 458 00:24:28,760 --> 00:24:30,680 Speaker 2: the things that you do. How much time do you 459 00:24:30,760 --> 00:24:33,520 Speaker 2: spend in nature? How much time are you behind a desk, 460 00:24:33,600 --> 00:24:35,840 Speaker 2: you know, sitting there hunched over you know, da da 461 00:24:35,880 --> 00:24:38,480 Speaker 2: da so I find it a bit empowering, you know, 462 00:24:38,520 --> 00:24:41,160 Speaker 2: from that perspective, because we do have some control even 463 00:24:41,200 --> 00:24:43,680 Speaker 2: though you have a genetic predisposition, you know, for something 464 00:24:43,680 --> 00:24:46,840 Speaker 2: like Alzheimer's, you know, you can't necessarily stop the onset 465 00:24:46,840 --> 00:24:49,199 Speaker 2: of the disease, but you can help support you know, 466 00:24:49,240 --> 00:24:52,000 Speaker 2: the onset of the condition and the symptoms and so 467 00:24:52,080 --> 00:24:54,959 Speaker 2: forth and similar you know, even with Alzheimer's, as we 468 00:24:54,960 --> 00:24:58,040 Speaker 2: were chatting about earlier, you know, there are protocols that 469 00:24:58,080 --> 00:25:02,080 Speaker 2: outline again behavioral modification changes, things that we can do 470 00:25:03,160 --> 00:25:05,359 Speaker 2: that ultimately can help prevent dementia, you know, so that 471 00:25:05,400 --> 00:25:06,560 Speaker 2: one is more preventable. 472 00:25:07,000 --> 00:25:11,640 Speaker 3: Yeah, absolutely, And and and actually interesting on dementia because 473 00:25:12,400 --> 00:25:17,600 Speaker 3: in Australia and I mean in America and in Australia 474 00:25:17,640 --> 00:25:19,600 Speaker 3: it's always been the UK the biggest killer has been 475 00:25:19,600 --> 00:25:23,919 Speaker 3: cardiovascular disease, and NI for the first time, the biggest 476 00:25:24,000 --> 00:25:25,720 Speaker 3: killer of females is actually dementia. 477 00:25:25,840 --> 00:25:28,040 Speaker 1: It's not cardiovascular disease, right. 478 00:25:28,000 --> 00:25:31,560 Speaker 3: And and and I think there is a there's an 479 00:25:31,600 --> 00:25:35,840 Speaker 3: explosion of dementia just around the court. Well, we're actually 480 00:25:35,840 --> 00:25:39,480 Speaker 3: starting to see it now, you know, with that metabolic 481 00:25:39,560 --> 00:25:42,600 Speaker 3: dysregulation that people have, you know that a lot of 482 00:25:42,600 --> 00:25:46,800 Speaker 3: people are calling it type three diabetes. So and and 483 00:25:47,320 --> 00:25:50,080 Speaker 3: what you mentioned around those protocols there was we just 484 00:25:50,080 --> 00:25:52,879 Speaker 3: talked offer that that Lancet paper that came out that 485 00:25:53,119 --> 00:25:57,439 Speaker 3: identified all of these risk factors for dementia and that 486 00:25:57,440 --> 00:26:02,920 Speaker 3: that by by implementing behavioraliant dimensions, you know, they estimated 487 00:26:03,000 --> 00:26:04,920 Speaker 3: they could reduce I can't remember when it was sixty 488 00:26:05,040 --> 00:26:07,760 Speaker 3: or seventy percent of dementia cases, right, which is pretty think. 489 00:26:07,600 --> 00:26:10,960 Speaker 2: It massive globally, And there's fifty five million you know, 490 00:26:11,080 --> 00:26:12,919 Speaker 2: has of the writing of that paper, So I mean 491 00:26:12,920 --> 00:26:15,840 Speaker 2: we're talking tens of millions of people that could be 492 00:26:15,880 --> 00:26:19,639 Speaker 2: supported through lifestyle and behavior. So yeah, it's definitely a 493 00:26:19,640 --> 00:26:22,600 Speaker 2: mission of ours. We are going to be publishing. You know, 494 00:26:22,640 --> 00:26:24,240 Speaker 2: you can find the paper online, but we put it 495 00:26:24,240 --> 00:26:26,560 Speaker 2: into a protocol. People can follow Paul and we'll be 496 00:26:26,640 --> 00:26:28,560 Speaker 2: giving us away and you know your readers would be 497 00:26:28,880 --> 00:26:31,439 Speaker 2: would have access to that. But that's the concept. And 498 00:26:31,480 --> 00:26:33,600 Speaker 2: imagine giving that to our parents and our grandparents. And 499 00:26:33,640 --> 00:26:35,840 Speaker 2: they shouldn't start in their sixties and seventies. They should 500 00:26:35,880 --> 00:26:36,280 Speaker 2: start now. 501 00:26:36,840 --> 00:26:39,960 Speaker 3: Yeah, that's some of the early research coming out. Nigh 502 00:26:40,119 --> 00:26:43,800 Speaker 3: is saying that that dementia and Alzheimer's are starting in 503 00:26:43,840 --> 00:26:47,600 Speaker 3: your thirties. And it starts with metabolism, right, it starts 504 00:26:47,640 --> 00:26:50,000 Speaker 3: with when you have that high. 505 00:26:49,760 --> 00:26:53,160 Speaker 1: Normal blood sugar, you're on the path. You are on 506 00:26:53,240 --> 00:26:54,120 Speaker 1: the path, right. 507 00:26:54,440 --> 00:26:58,520 Speaker 3: And so we've talked about the protocol, So so let's 508 00:26:58,560 --> 00:27:00,240 Speaker 3: let's talk a little bit about what you do in 509 00:27:00,400 --> 00:27:04,440 Speaker 3: breen one and so just say I'm a typical person 510 00:27:04,440 --> 00:27:08,040 Speaker 3: who comes in through my company or whatever to bring 511 00:27:08,160 --> 00:27:11,360 Speaker 3: one what what what happens? 512 00:27:12,280 --> 00:27:16,399 Speaker 2: Yeah, so we look at the world again based in 513 00:27:16,440 --> 00:27:19,159 Speaker 2: the concept of a protocol. And the protocol is just 514 00:27:19,200 --> 00:27:21,800 Speaker 2: your routine. You know, like Paul, what do you do 515 00:27:21,840 --> 00:27:23,080 Speaker 2: when you get up in the morning. You know, what 516 00:27:23,119 --> 00:27:25,080 Speaker 2: are the ten things you do before you really start 517 00:27:25,119 --> 00:27:29,600 Speaker 2: your day. And so we consider the protocols the framework, 518 00:27:29,640 --> 00:27:31,760 Speaker 2: and then the things that you do or micro habits 519 00:27:31,800 --> 00:27:35,720 Speaker 2: just to oversimplify it. And so we will take a 520 00:27:35,760 --> 00:27:38,439 Speaker 2: scientific paper, we run it through our AI. We generate 521 00:27:38,480 --> 00:27:41,320 Speaker 2: these protocols and then we can tailor them. This concept 522 00:27:41,320 --> 00:27:45,920 Speaker 2: of adaptive AI based on the human based on their demographics, 523 00:27:45,960 --> 00:27:48,760 Speaker 2: based on their genetics, based on their it could be 524 00:27:48,800 --> 00:27:51,560 Speaker 2: a brain scan. We just partnered with an EEG device 525 00:27:51,680 --> 00:27:55,560 Speaker 2: where we can now incorporate EEG data or BCI data 526 00:27:55,600 --> 00:27:58,520 Speaker 2: into these profiles essentially, and then we give them a 527 00:27:58,640 --> 00:28:02,960 Speaker 2: hyper personalized tailor program essentially based on the protocol and 528 00:28:02,960 --> 00:28:05,919 Speaker 2: the micro habits is the concept, and we do that 529 00:28:06,000 --> 00:28:09,720 Speaker 2: on a corporate level. We do it working with concierge doctors. 530 00:28:10,119 --> 00:28:13,959 Speaker 2: That's really been our major focus longevity, you know, that space, 531 00:28:14,000 --> 00:28:17,680 Speaker 2: because it's exploding. We actually just launched peptides dot one, 532 00:28:17,960 --> 00:28:21,320 Speaker 2: which is a offshoot of brain dot one. It's peptides 533 00:28:21,359 --> 00:28:23,560 Speaker 2: with an A S. And you know, the vision there 534 00:28:23,640 --> 00:28:26,760 Speaker 2: is to actually provide information support of people that are 535 00:28:26,800 --> 00:28:31,160 Speaker 2: looking to you know, find quality peptides, which is a challenge. 536 00:28:31,640 --> 00:28:33,359 Speaker 2: You know, we're in this kind of inflection point at 537 00:28:33,440 --> 00:28:36,280 Speaker 2: least here in the States where a lot of these things, 538 00:28:36,320 --> 00:28:38,240 Speaker 2: you know, I've been doing for years as a triathlete. 539 00:28:38,240 --> 00:28:40,920 Speaker 2: I mean, we've been doing peptides for like decades, you know, 540 00:28:41,000 --> 00:28:43,160 Speaker 2: in some cases red light, you know, I've had friends 541 00:28:43,200 --> 00:28:44,920 Speaker 2: that have been doing red light, cold plunging, you know, 542 00:28:44,960 --> 00:28:48,200 Speaker 2: all these things we've used in trathlon for recovery, you know, 543 00:28:48,280 --> 00:28:51,400 Speaker 2: and so forth. But now they're going really mainstream, and 544 00:28:51,440 --> 00:28:53,320 Speaker 2: so that's cool. You know, more and more people have 545 00:28:53,360 --> 00:28:56,360 Speaker 2: access to these awesome tools. But that's kind of just 546 00:28:56,440 --> 00:28:59,360 Speaker 2: the general framework of brain one peptides one is just 547 00:28:59,400 --> 00:29:02,840 Speaker 2: having a essentially a platform for measurement ultimately. 548 00:29:03,160 --> 00:29:06,200 Speaker 3: And well do peptides then I want to come back 549 00:29:06,240 --> 00:29:07,440 Speaker 3: to the to the platform. 550 00:29:07,680 --> 00:29:10,800 Speaker 1: So what what is the what's the status? 551 00:29:10,840 --> 00:29:14,280 Speaker 3: What's the legal status of peptides in the States because 552 00:29:14,840 --> 00:29:17,720 Speaker 3: in Australia, and I think it's pretty similar in the UK, 553 00:29:18,480 --> 00:29:22,200 Speaker 3: and I could go online and I can buy peptides 554 00:29:22,800 --> 00:29:28,040 Speaker 3: for research purposes own, right, I can't a doctor over 555 00:29:28,080 --> 00:29:31,720 Speaker 3: here cannot administer peptides to me because they're they're not 556 00:29:31,800 --> 00:29:36,680 Speaker 3: approved by the TGA. But anecdotally there is a shitload 557 00:29:36,760 --> 00:29:40,200 Speaker 3: of people who are using peptides and it's a bit 558 00:29:40,240 --> 00:29:44,320 Speaker 3: of wild wes, right, because there's no regulation, you don't 559 00:29:44,400 --> 00:29:48,480 Speaker 3: really know like is this is this BPC one five 560 00:29:48,520 --> 00:29:51,440 Speaker 3: seven and I'm buying? Is it actually BPC one five seven? 561 00:29:51,520 --> 00:29:53,840 Speaker 3: Is it quality stuff? Is it not quality stuff? 562 00:29:54,360 --> 00:29:57,520 Speaker 1: So? So what's the what is the landscape in the States, 563 00:29:57,560 --> 00:29:58,720 Speaker 1: Because I know there are. 564 00:29:58,760 --> 00:30:03,320 Speaker 3: Clinics over there so and there's there's doctors who will 565 00:30:03,720 --> 00:30:06,840 Speaker 3: administer them, so it's clearly a bit different over there. 566 00:30:06,880 --> 00:30:10,400 Speaker 3: And I think probably going to be different gain because 567 00:30:10,400 --> 00:30:11,480 Speaker 3: I think JFK is a. 568 00:30:11,400 --> 00:30:14,560 Speaker 1: Big found of peptides, isn't he sore? Where are we 569 00:30:14,600 --> 00:30:16,160 Speaker 1: in terms of the status over there? 570 00:30:16,560 --> 00:30:19,600 Speaker 2: We're in a shift. So when you talk about peptides 571 00:30:19,640 --> 00:30:22,280 Speaker 2: again short chain amino acids, you know, over here you 572 00:30:22,280 --> 00:30:27,320 Speaker 2: have the glps and glps are exploding. I mean it's insane. 573 00:30:28,440 --> 00:30:31,160 Speaker 2: You know the number of humans who are now injecting themselves, 574 00:30:31,160 --> 00:30:34,440 Speaker 2: which I've mixed feelings about. I think there's a time 575 00:30:34,480 --> 00:30:36,520 Speaker 2: and a place for glps. And you know, there's also 576 00:30:36,560 --> 00:30:40,640 Speaker 2: some other areas that the research has shown they're quite efficacious, 577 00:30:40,680 --> 00:30:43,800 Speaker 2: like within women's health PCOS as an example. Actually women 578 00:30:43,920 --> 00:30:46,840 Speaker 2: are on low doos glps. You know, there's some positive 579 00:30:47,480 --> 00:30:51,160 Speaker 2: effects there. But you know, so like they have been, 580 00:30:51,200 --> 00:30:53,800 Speaker 2: I'd say glps have kind of opened the floodgates. So 581 00:30:53,880 --> 00:30:56,520 Speaker 2: now people where again ten years ago, we were doing 582 00:30:56,600 --> 00:31:01,200 Speaker 2: VPC and you know, no one knew GLP one was 583 00:31:01,360 --> 00:31:04,160 Speaker 2: is it? One is? And so now what's happening is 584 00:31:05,080 --> 00:31:08,360 Speaker 2: people are exploring further because they're seeing positive impacts from 585 00:31:08,360 --> 00:31:10,880 Speaker 2: things like glps, and then it's opening, you know, the 586 00:31:10,880 --> 00:31:14,520 Speaker 2: flood gates again of like TV five hundred and BPC 587 00:31:14,880 --> 00:31:18,040 Speaker 2: and the wolverine and you know this. I mean there's 588 00:31:18,360 --> 00:31:20,880 Speaker 2: you know, while there's there's really only about twenty to 589 00:31:20,920 --> 00:31:23,480 Speaker 2: thirty peptides that are like you know, the major players 590 00:31:23,480 --> 00:31:26,000 Speaker 2: in the space, ultimately there's really not that many all 591 00:31:26,040 --> 00:31:28,600 Speaker 2: at all. And so what's happening in the US is 592 00:31:28,640 --> 00:31:32,880 Speaker 2: because of RFK, they're getting reclassified essentially. And I heard 593 00:31:32,920 --> 00:31:37,440 Speaker 2: this week about midweek he will be talking through the 594 00:31:37,480 --> 00:31:40,160 Speaker 2: next five that are going to be reclassified. And if 595 00:31:40,160 --> 00:31:41,480 Speaker 2: I had to guess, it's going to be you know, 596 00:31:41,520 --> 00:31:46,720 Speaker 2: the tv TB five hundred BPC, uh, maybe GHK, you know, 597 00:31:46,800 --> 00:31:50,640 Speaker 2: CEU and so forth. So we're seeing it right now. 598 00:31:50,800 --> 00:31:53,640 Speaker 2: And the good news is that and maybe unlike you 599 00:31:53,680 --> 00:31:57,160 Speaker 2: know in Australia, but you have again these FDA approved 600 00:31:57,240 --> 00:31:58,840 Speaker 2: peptides you can get from your doctor. 601 00:31:59,240 --> 00:32:01,560 Speaker 3: So at least in that is that sorry, is that 602 00:32:01,680 --> 00:32:03,880 Speaker 3: currently you can you can actually. 603 00:32:03,600 --> 00:32:06,640 Speaker 2: Yeah, there's but there's a few you know, of course 604 00:32:06,760 --> 00:32:09,360 Speaker 2: again with like GLP ones, but there's like a handful 605 00:32:09,520 --> 00:32:12,640 Speaker 2: you can get now. And then with this reclassification, you're 606 00:32:12,640 --> 00:32:14,040 Speaker 2: going to be able to get you know, these ones 607 00:32:14,040 --> 00:32:16,760 Speaker 2: that are much more prevalent, like the vpcs and so forth. 608 00:32:16,920 --> 00:32:20,120 Speaker 3: Right, But right now, if somebody wants to in the States, 609 00:32:20,120 --> 00:32:23,880 Speaker 3: if they wanted to get a wolverine stacks, we should 610 00:32:23,880 --> 00:32:25,240 Speaker 3: sort of explain this for people. 611 00:32:25,280 --> 00:32:26,640 Speaker 1: So BPC one. 612 00:32:26,600 --> 00:32:32,040 Speaker 3: Five seven TV five hundred R essentially powerful anti inflammatory 613 00:32:32,040 --> 00:32:35,280 Speaker 3: peptides help wound healing, all of these sorts of things. Right, 614 00:32:35,360 --> 00:32:40,040 Speaker 3: But what so is it similar similar to Australia where 615 00:32:40,080 --> 00:32:41,880 Speaker 3: it's a kind of a gray area where you can 616 00:32:41,920 --> 00:32:45,680 Speaker 3: buy them for research purposes or can you officially go 617 00:32:45,840 --> 00:32:48,320 Speaker 3: to a doctor and get a script now I know 618 00:32:48,360 --> 00:32:51,320 Speaker 3: you can for GPS, but for those other ones? 619 00:32:51,960 --> 00:32:53,360 Speaker 1: Is it a gray area right now? 620 00:32:53,360 --> 00:32:56,440 Speaker 2: It's a gray area right now, it's about to right, Okay, 621 00:32:56,480 --> 00:32:59,960 Speaker 2: So it's quite similar, right, yeah, yeah, it's exactly the same. 622 00:33:00,200 --> 00:33:02,880 Speaker 2: And to your point, you know, further getting them from 623 00:33:02,920 --> 00:33:04,920 Speaker 2: the gray you know, the gray market. You don't know 624 00:33:04,960 --> 00:33:07,320 Speaker 2: where that molecules coming from. You don't know if it's 625 00:33:07,360 --> 00:33:10,480 Speaker 2: been mass spect or run on a mass spectro photometer 626 00:33:10,600 --> 00:33:14,120 Speaker 2: to understand the molecular composition. You don't know the quality, 627 00:33:14,240 --> 00:33:18,520 Speaker 2: if there's contaminants, fungi, you know, biologics. I mean, so 628 00:33:18,600 --> 00:33:20,760 Speaker 2: it's and a lot of these are coming from China 629 00:33:21,280 --> 00:33:24,800 Speaker 2: and most the precursors are absolutely coming from China, So 630 00:33:25,840 --> 00:33:28,400 Speaker 2: you know it's a it is a concern for sure, 631 00:33:28,400 --> 00:33:30,200 Speaker 2: but it's not new. I mean again, having been this 632 00:33:30,680 --> 00:33:33,880 Speaker 2: for many years, it's only gotten i would say exacerbated 633 00:33:33,880 --> 00:33:36,440 Speaker 2: because there's so much more demand. And now we call 634 00:33:36,480 --> 00:33:41,200 Speaker 2: it peptide broification. Uh but uh, you know, like every 635 00:33:41,440 --> 00:33:44,760 Speaker 2: it's like every you know, crypto cannabis bro is now 636 00:33:44,760 --> 00:33:48,800 Speaker 2: going into peptides and it's fairly tough, right, interesting because 637 00:33:48,840 --> 00:33:51,640 Speaker 2: it's such a gold rush. And so you know, back 638 00:33:51,640 --> 00:33:53,560 Speaker 2: to what we do at Brain one Peptides one. We 639 00:33:53,640 --> 00:33:57,120 Speaker 2: provide a framework for people to measure if the peptides work. 640 00:33:57,360 --> 00:33:59,840 Speaker 2: You know, like you can actually see you start taking 641 00:33:59,840 --> 00:34:02,120 Speaker 2: it on a certain day, I'd be considered an intervention. 642 00:34:02,520 --> 00:34:04,400 Speaker 2: You have a baseline of a period of time, it 643 00:34:04,400 --> 00:34:06,880 Speaker 2: could be one week, two weeks depending and then you 644 00:34:07,120 --> 00:34:09,720 Speaker 2: just see, you know, how to your biometrics, biro markers improve. 645 00:34:09,920 --> 00:34:14,640 Speaker 3: Okay, sure, you're people are constantly uploading their data, uploading 646 00:34:14,680 --> 00:34:16,840 Speaker 3: their data from their Apple Watch or whatever it may be, 647 00:34:17,680 --> 00:34:21,439 Speaker 3: getting getting stuff from their doctor, uploading their blood work, 648 00:34:21,719 --> 00:34:24,719 Speaker 3: and you're analyzing all of that in the back end. 649 00:34:24,800 --> 00:34:27,920 Speaker 2: Yeah, correct, Yeah, they just they connect to wearable once 650 00:34:28,280 --> 00:34:30,960 Speaker 2: and then we have different types of scans you can 651 00:34:31,000 --> 00:34:32,600 Speaker 2: do in the app. You can do a voice scan 652 00:34:33,160 --> 00:34:35,560 Speaker 2: and we get fifteen biomarkers from voice. 653 00:34:35,600 --> 00:34:38,319 Speaker 1: We get about four from void from voice from. 654 00:34:38,239 --> 00:34:42,319 Speaker 2: Absolutely absolutely yeah HRV. Honestly I did. We did analysis. 655 00:34:42,320 --> 00:34:45,000 Speaker 2: We saw HRV coming from voice was within five percent 656 00:34:45,040 --> 00:34:45,920 Speaker 2: of what I saw in my. 657 00:34:45,880 --> 00:34:47,560 Speaker 1: Whoop get away. 658 00:34:47,680 --> 00:34:50,640 Speaker 2: Yeah, oh absolutely your voice. You know tension, I mean 659 00:34:50,680 --> 00:34:52,800 Speaker 2: you hear it in someone's voice, you know, in they're tense. 660 00:34:53,160 --> 00:34:54,480 Speaker 2: So even if you just think of it as a 661 00:34:54,480 --> 00:34:59,399 Speaker 2: stress monitor, it's incredible some of the biomarkers that they talk. 662 00:34:59,440 --> 00:35:02,440 Speaker 2: I don't know if I yet, but it's coming, you know. Uh. 663 00:35:02,480 --> 00:35:05,319 Speaker 2: And similar with the face I mean hypertension. HRV have 664 00:35:05,400 --> 00:35:09,080 Speaker 2: also seen it, you know, within within face scans as well. 665 00:35:09,680 --> 00:35:12,520 Speaker 2: So if someone you know, they can they can connect 666 00:35:12,600 --> 00:35:15,680 Speaker 2: their their wearable one time, that's it and then they 667 00:35:15,719 --> 00:35:18,160 Speaker 2: could do these regular you know types of tests and 668 00:35:18,200 --> 00:35:21,520 Speaker 2: then that can also include blood of course, but there's 669 00:35:21,600 --> 00:35:24,279 Speaker 2: challenges with blood as well, you know, relative to when 670 00:35:24,320 --> 00:35:26,719 Speaker 2: you take it, you know, how you take it. You know, 671 00:35:26,840 --> 00:35:30,240 Speaker 2: you get oxidation, you get to naturing of proteins with heat, 672 00:35:30,640 --> 00:35:31,480 Speaker 2: you know, blood. 673 00:35:31,200 --> 00:35:34,920 Speaker 3: Which which lab, which lab has taken it as well, 674 00:35:34,960 --> 00:35:36,200 Speaker 3: because you know, some of. 675 00:35:36,160 --> 00:35:38,480 Speaker 1: The labs are very slightly different. 676 00:35:38,719 --> 00:35:41,360 Speaker 3: I mean to to go back to just just to 677 00:35:41,360 --> 00:35:43,960 Speaker 3: to kind of shine a light on this whole area. 678 00:35:44,120 --> 00:35:47,200 Speaker 3: As you rightly said, like your your blood mark, the 679 00:35:47,239 --> 00:35:50,080 Speaker 3: time that you get it done can be different. Obviously 680 00:35:50,080 --> 00:35:53,920 Speaker 3: everybody knows about fasting versus non fasting, but but that 681 00:35:53,920 --> 00:35:56,720 Speaker 3: that time in your chacidian rhythm, if you're a female, 682 00:35:56,760 --> 00:35:59,239 Speaker 3: where you are in your menstrual cycle, you know you're 683 00:35:59,719 --> 00:36:02,560 Speaker 3: you're sleep last night. They all of these things affected. 684 00:36:02,719 --> 00:36:06,680 Speaker 3: But you know, if we talk about the whole peptide world. 685 00:36:06,760 --> 00:36:09,719 Speaker 3: So JLP's are really interesting, right because they have been 686 00:36:09,760 --> 00:36:13,680 Speaker 3: around for quite some time, right, the early versions of 687 00:36:13,719 --> 00:36:17,600 Speaker 3: the GLP ones were around well over a decade ago. 688 00:36:18,800 --> 00:36:23,080 Speaker 3: But now we are really nih just starting to see 689 00:36:23,360 --> 00:36:26,960 Speaker 3: some of the data come through. And whilst there's very 690 00:36:27,120 --> 00:36:31,200 Speaker 3: very interesting data. Obviously everybody knows around the weight loss, 691 00:36:31,400 --> 00:36:35,040 Speaker 3: but there seems to be early around cardiovascular disease protection, 692 00:36:35,520 --> 00:36:39,279 Speaker 3: potentially something around dementia, some early signals around that. 693 00:36:39,480 --> 00:36:40,800 Speaker 1: But interesting. 694 00:36:40,840 --> 00:36:44,880 Speaker 3: I just read a paper yesterday on people on GLP ones, 695 00:36:45,120 --> 00:36:48,439 Speaker 3: about fifty percent of them have to come off within 696 00:36:48,480 --> 00:36:52,040 Speaker 3: the first year because of the side effects, right, which 697 00:36:52,080 --> 00:36:55,160 Speaker 3: I think they are. The side effects are more prevalent 698 00:36:55,239 --> 00:36:58,640 Speaker 3: than people know. And interesting when you look at the 699 00:36:58,719 --> 00:37:03,800 Speaker 3: biomarkers in a paper, like people were having great bio 700 00:37:03,880 --> 00:37:08,560 Speaker 3: markers when they're on the glps and clear reductions and 701 00:37:08,760 --> 00:37:12,560 Speaker 3: risk factors for a number of different diseases. So looking 702 00:37:12,600 --> 00:37:17,400 Speaker 3: pretty awesome, like liver fat being obliterated, and that's some 703 00:37:17,440 --> 00:37:20,600 Speaker 3: of the stuff on reditory chide and some of the 704 00:37:20,640 --> 00:37:24,479 Speaker 3: stuff around liver fat. But then when people go off 705 00:37:24,600 --> 00:37:30,160 Speaker 3: the golp ones, they put the weight on really really quick, 706 00:37:30,239 --> 00:37:33,960 Speaker 3: like four times as fast as people who've been dieting, 707 00:37:34,760 --> 00:37:38,200 Speaker 3: and all of their markers get. 708 00:37:38,160 --> 00:37:44,040 Speaker 1: Really bad, really really quick. Right, And this is my 709 00:37:44,360 --> 00:37:46,200 Speaker 1: concern with those. 710 00:37:46,480 --> 00:37:49,759 Speaker 3: And then you know, we step into the bigger peptide 711 00:37:49,840 --> 00:37:52,799 Speaker 3: world where you go all those things that we talked 712 00:37:52,800 --> 00:37:55,279 Speaker 3: about before that people are getting on the gray market, Well, 713 00:37:55,920 --> 00:37:58,560 Speaker 3: they haven't had the clinical trials done on them yet. 714 00:37:58,640 --> 00:38:01,160 Speaker 3: And yes, there's lots of onecdotal stuff that you can 715 00:38:01,200 --> 00:38:03,560 Speaker 3: talk to your me. You took PPC and his injury 716 00:38:03,960 --> 00:38:07,319 Speaker 3: got really good, really quick, But again we do not 717 00:38:07,680 --> 00:38:10,440 Speaker 3: know the long term effects yet, right. 718 00:38:11,120 --> 00:38:15,719 Speaker 2: Yeah, truly not I would agree, So, yeah, slightly terrifying 719 00:38:15,760 --> 00:38:21,600 Speaker 2: from from that perspective. Yeah, we where I see a 720 00:38:21,680 --> 00:38:24,560 Speaker 2: market need or just a human need is like the 721 00:38:24,600 --> 00:38:30,719 Speaker 2: concept of microdosing jlps. You know, that's last year. I 722 00:38:30,719 --> 00:38:33,400 Speaker 2: think that makes a lot more sense, depending you know, 723 00:38:33,440 --> 00:38:36,000 Speaker 2: on the on the human and the condition. And then 724 00:38:36,160 --> 00:38:38,719 Speaker 2: just the concept of like tight trading down, you know, 725 00:38:38,840 --> 00:38:41,960 Speaker 2: like how do you go off especially a full jos GLP. 726 00:38:42,200 --> 00:38:44,920 Speaker 2: And then you know, ultimately just to your point going, 727 00:38:45,840 --> 00:38:47,600 Speaker 2: you know, you don't want to go cool turkey on 728 00:38:47,640 --> 00:38:50,320 Speaker 2: these things. So is there a mechanism to tight trade 729 00:38:50,400 --> 00:38:53,400 Speaker 2: you know, essentially down. Finally, like we talked about, you 730 00:38:53,440 --> 00:38:55,759 Speaker 2: know with triathlon training, you're you're tight trading up. You know, 731 00:38:55,800 --> 00:38:59,160 Speaker 2: it's similar. I think there's a sweet spot for people 732 00:38:59,200 --> 00:39:01,399 Speaker 2: that could be very very beneficial, you. 733 00:39:01,360 --> 00:39:03,480 Speaker 1: Know, and oh oh absolutely. 734 00:39:03,560 --> 00:39:06,200 Speaker 3: I mean you look at the research coming out of 735 00:39:06,200 --> 00:39:08,440 Speaker 3: If you're on an antidepressant and you try and go 736 00:39:08,520 --> 00:39:12,200 Speaker 3: cold turkey, Jesus Christ, you're in for a world of 737 00:39:12,320 --> 00:39:15,840 Speaker 3: pee and you've got to really tight trait that dime on. 738 00:39:17,760 --> 00:39:18,720 Speaker 1: Very very slowly. 739 00:39:18,760 --> 00:39:20,520 Speaker 3: And I think I think it's probably the same for 740 00:39:20,640 --> 00:39:24,360 Speaker 3: any drug, right, but particularly the GLPS. I agree and 741 00:39:24,560 --> 00:39:26,480 Speaker 3: Jesus Christ, you've got to be lifting. You've got to 742 00:39:26,520 --> 00:39:28,160 Speaker 3: be doing resistance training when you're on that. 743 00:39:28,200 --> 00:39:31,720 Speaker 2: Well, I was going to say that the muscle loss 744 00:39:31,760 --> 00:39:34,479 Speaker 2: like more than anything. I mean, you know, talk about 745 00:39:34,480 --> 00:39:37,920 Speaker 2: a longevity hack, you know, like it's been tried and true. 746 00:39:38,120 --> 00:39:41,239 Speaker 2: You know, ultimately weights, yeah, you know, into your later 747 00:39:41,280 --> 00:39:43,920 Speaker 2: stages of life, like sixty seventy, keep going. It doesn't 748 00:39:43,920 --> 00:39:46,319 Speaker 2: have to be heavy, but continue doing weights. You know, 749 00:39:46,400 --> 00:39:48,359 Speaker 2: it's like nearly indisputable. 750 00:39:49,160 --> 00:39:52,200 Speaker 3: I actually think, you know, when we look when when 751 00:39:52,239 --> 00:39:56,759 Speaker 3: you look at it, resistance training I think has been 752 00:39:57,080 --> 00:40:00,360 Speaker 3: massively underappreciated over the years. I mean, I've been an 753 00:40:00,360 --> 00:40:06,200 Speaker 3: exercise scientist for thirty years. We've been talking about cardiovascular training, 754 00:40:06,360 --> 00:40:09,920 Speaker 3: and for very good reason, right but I think now 755 00:40:10,360 --> 00:40:15,640 Speaker 3: just seeing the independent and synergistic benefits of resistance training, 756 00:40:15,840 --> 00:40:20,880 Speaker 3: and particularly as we eage as an aging population, I 757 00:40:20,960 --> 00:40:25,719 Speaker 3: actually think that sarcopenia, which is that progressive loss of 758 00:40:25,760 --> 00:40:30,320 Speaker 3: bone and muscle, I actually think it's probably the biggest killer. 759 00:40:30,560 --> 00:40:33,319 Speaker 3: Right now, people go, hold on, what do you mean 760 00:40:33,480 --> 00:40:36,520 Speaker 3: that's ridiculous. Cardiovascular disease is the biggest killer. We're not 761 00:40:36,600 --> 00:40:37,360 Speaker 3: seeing dementia. 762 00:40:37,440 --> 00:40:39,880 Speaker 1: But so if you if. 763 00:40:39,760 --> 00:40:44,960 Speaker 3: You're in your sixties, falls are the seventh biggest killer. 764 00:40:45,280 --> 00:40:48,320 Speaker 3: And the falls generally come because people have lost muscle 765 00:40:48,360 --> 00:40:51,640 Speaker 3: and particularly those fast twitch fibers that you know you're 766 00:40:51,680 --> 00:40:54,879 Speaker 3: reaching out to grab something ere regaining your feet when 767 00:40:54,880 --> 00:40:57,680 Speaker 3: you get into your seventies, falls are the fifth biggest. 768 00:40:57,360 --> 00:40:58,560 Speaker 1: Killer of everybody. 769 00:40:58,680 --> 00:41:03,000 Speaker 3: Right, But if you have low muscle mass, you dramatically 770 00:41:03,000 --> 00:41:06,480 Speaker 3: increase your risk of cardiovascular disease, you dramatically increase your 771 00:41:06,560 --> 00:41:12,200 Speaker 3: risk of dimension your degenerative diseases, and you dramatically increase 772 00:41:12,239 --> 00:41:16,239 Speaker 3: your risk of metabolic diseases like diabetes. So I think 773 00:41:16,239 --> 00:41:19,799 Speaker 3: if we look at not just it on itself, but 774 00:41:19,880 --> 00:41:25,000 Speaker 3: the impact on other things, I actually think low muscle 775 00:41:25,080 --> 00:41:28,040 Speaker 3: mass is one of the biggest killers out there. 776 00:41:28,440 --> 00:41:31,600 Speaker 1: And oh have you got any thinking on that? Yeah? 777 00:41:31,680 --> 00:41:34,319 Speaker 2: No, I mean absolutely. Again, you know, we talk about it. 778 00:41:35,160 --> 00:41:37,520 Speaker 2: A lot of people are interested in these longevity hacks, 779 00:41:37,600 --> 00:41:39,040 Speaker 2: you know, like what can I do? What are the 780 00:41:39,120 --> 00:41:41,560 Speaker 2: quick easy fixes? And so again we really focus on 781 00:41:41,560 --> 00:41:45,600 Speaker 2: the behavioral side. But again, muscle mass is everything, and 782 00:41:45,640 --> 00:41:47,320 Speaker 2: it doesn't you know, you don't have to be ripped, 783 00:41:47,320 --> 00:41:50,520 Speaker 2: but just doing again resistance training any type of weights 784 00:41:50,560 --> 00:41:53,280 Speaker 2: again into your older age like absolutely critical. 785 00:41:53,440 --> 00:41:55,200 Speaker 1: So couldn't agree more. 786 00:41:55,760 --> 00:41:58,960 Speaker 3: And so you talk we need to wind up a 787 00:41:59,000 --> 00:42:03,560 Speaker 3: little bit, but you also talk about behavioral design right, 788 00:42:03,719 --> 00:42:06,560 Speaker 3: which I'm a fan of as well. So so give 789 00:42:06,640 --> 00:42:10,879 Speaker 3: us give our listeners some practical tools that they can 790 00:42:10,920 --> 00:42:16,040 Speaker 3: do around behavioral design to close what what I call 791 00:42:16,120 --> 00:42:18,520 Speaker 3: the knowing doing gap. Are lots of people called it 792 00:42:18,640 --> 00:42:20,279 Speaker 3: right because there's a lot of people listening to this. 793 00:42:20,719 --> 00:42:23,239 Speaker 3: They know what they need to do, but they're not 794 00:42:23,320 --> 00:42:25,640 Speaker 3: quite doing it right. I say, they're waiting for the 795 00:42:25,760 --> 00:42:31,200 Speaker 3: motivation ferry. But what are some little behavioral design hacks 796 00:42:31,280 --> 00:42:33,920 Speaker 3: that that that you have come up with, or that. 797 00:42:33,680 --> 00:42:37,200 Speaker 1: That your system uses people can actually use. 798 00:42:37,600 --> 00:42:40,280 Speaker 2: Yes, so we have thousands of these actually in the system. 799 00:42:40,560 --> 00:42:44,560 Speaker 2: And you know, so for sleep, as an example, you 800 00:42:44,560 --> 00:42:46,880 Speaker 2: want to improve your sleep, well, what can help improve 801 00:42:46,880 --> 00:42:49,399 Speaker 2: your sleep is when you get in the morning, get 802 00:42:49,480 --> 00:42:51,879 Speaker 2: up in the morning. You know your direct sunlight, your 803 00:42:51,920 --> 00:42:56,359 Speaker 2: secedian regulation, and of course cortisol, and you know all 804 00:42:56,400 --> 00:42:58,880 Speaker 2: of these additional stress hormones that actually start in the 805 00:42:58,880 --> 00:43:02,440 Speaker 2: morning but that impact sleep at night. And so you know, 806 00:43:02,520 --> 00:43:05,000 Speaker 2: big fan in the mornings if you can get the 807 00:43:05,040 --> 00:43:07,600 Speaker 2: direct sunlight. I live in a valley here in Colorado. 808 00:43:07,760 --> 00:43:09,879 Speaker 2: So I don't actually get direct sunlight till about nine, 809 00:43:10,520 --> 00:43:13,360 Speaker 2: but as soon as you can do it, it's absolutely 810 00:43:13,400 --> 00:43:16,440 Speaker 2: a beneficial microhabit as we would call it. And you 811 00:43:16,480 --> 00:43:20,000 Speaker 2: can combine that, you know, after breakfast doing a twenty 812 00:43:20,000 --> 00:43:22,279 Speaker 2: minute walk, you know, in the sunshine, and try to 813 00:43:22,280 --> 00:43:24,840 Speaker 2: get you know, both of those things, you know, with hydration, 814 00:43:24,960 --> 00:43:27,120 Speaker 2: which sounds very rudimentary, you know, but people do not 815 00:43:27,200 --> 00:43:30,399 Speaker 2: drink enough water period. Yeah, So you know, those would 816 00:43:30,400 --> 00:43:33,319 Speaker 2: be like three examples of three micro habits. Also, the 817 00:43:33,320 --> 00:43:36,359 Speaker 2: power of connection in community. You know, people who wake 818 00:43:36,440 --> 00:43:39,160 Speaker 2: up in the morning and feel a connection to something. 819 00:43:39,360 --> 00:43:41,280 Speaker 2: You can call it God, you can call it yourself, 820 00:43:41,280 --> 00:43:43,640 Speaker 2: you can call it nature. It doesn't really matter. But 821 00:43:43,760 --> 00:43:47,520 Speaker 2: having that connection that purpose your life expectancy can go up, 822 00:43:47,520 --> 00:43:50,600 Speaker 2: you know, ten plus years just by having that connection. 823 00:43:51,640 --> 00:43:53,919 Speaker 2: An extension that could be community, the people you surround 824 00:43:53,960 --> 00:43:56,360 Speaker 2: yourself with, the things that you do, could be a 825 00:43:56,360 --> 00:43:59,319 Speaker 2: book club, could be you know, bingo. I mean, it 826 00:43:59,360 --> 00:44:02,640 Speaker 2: doesn't really matter as long as you're with people and 827 00:44:02,840 --> 00:44:05,200 Speaker 2: you know, keeping that connection up. So you know, as 828 00:44:05,239 --> 00:44:07,560 Speaker 2: a data scientists and maleculobologist, I'm always looking at the 829 00:44:07,640 --> 00:44:09,759 Speaker 2: data and like trying to see you know, like how 830 00:44:09,760 --> 00:44:12,640 Speaker 2: do we measure this thing? But like community as an example, 831 00:44:12,719 --> 00:44:14,799 Speaker 2: you know, it's it's a very tried and true there's 832 00:44:14,880 --> 00:44:16,920 Speaker 2: enough papers around this. You know, people who have strong 833 00:44:17,000 --> 00:44:20,239 Speaker 2: senses of community live longer. People who are in isolation 834 00:44:20,400 --> 00:44:23,200 Speaker 2: that have things like hearing loss or traumatic brain injury, 835 00:44:23,520 --> 00:44:26,439 Speaker 2: you know, they live shorter lives ultimately. And the good 836 00:44:26,440 --> 00:44:28,080 Speaker 2: news is that again, these are things that we can 837 00:44:28,120 --> 00:44:31,440 Speaker 2: improve once you're cognizant of them and just come up 838 00:44:31,480 --> 00:44:33,880 Speaker 2: with the framework. We call it a protocol. It's literally 839 00:44:33,920 --> 00:44:36,040 Speaker 2: just a routine or a list, you know, and you 840 00:44:36,080 --> 00:44:37,560 Speaker 2: try to do the best you can, and you don't 841 00:44:37,560 --> 00:44:39,799 Speaker 2: beat yourself up, and you start small. You start with 842 00:44:39,920 --> 00:44:42,920 Speaker 2: one or two of these behavioral changes and then they 843 00:44:42,960 --> 00:44:45,000 Speaker 2: grow incrementally. But if you try to do it all 844 00:44:45,040 --> 00:44:47,520 Speaker 2: at once, it's like the people that diet after the 845 00:44:47,560 --> 00:44:51,920 Speaker 2: New Year, you're going to fail. So small micro habits 846 00:44:51,960 --> 00:44:55,000 Speaker 2: that have you know, compounding interest essentially over time. 847 00:44:56,280 --> 00:45:00,560 Speaker 3: And you then are helping people with Brehamong, are helping 848 00:45:00,600 --> 00:45:06,759 Speaker 3: them to measure their progress. And do you suggest or 849 00:45:06,800 --> 00:45:10,279 Speaker 3: does the AI suggest behavioral tweaks that people. 850 00:45:10,040 --> 00:45:13,560 Speaker 2: Can do based that's correct. Yeah, that's when we call 851 00:45:13,600 --> 00:45:16,759 Speaker 2: that adaptive AI. It's that concept. You know. We could 852 00:45:16,800 --> 00:45:19,600 Speaker 2: upload our data right now, Paul, and you know it 853 00:45:19,800 --> 00:45:23,480 Speaker 2: give us a blueprint, and then we can upload our biometrics. 854 00:45:23,840 --> 00:45:26,160 Speaker 2: We could have biomarkers, and that would be a snapshot 855 00:45:26,160 --> 00:45:28,200 Speaker 2: at this moment in time. But it changes, you know, 856 00:45:28,239 --> 00:45:30,560 Speaker 2: your biology changes. I mean that's the thing with blood. 857 00:45:30,600 --> 00:45:32,760 Speaker 2: You know, you can fast, but at the day before 858 00:45:33,280 --> 00:45:35,680 Speaker 2: you have a high carbohydrate or a high protein you 859 00:45:35,680 --> 00:45:38,080 Speaker 2: know day you know that might impact your blood work. 860 00:45:38,239 --> 00:45:40,799 Speaker 2: So we really look at things, you know, similar to 861 00:45:40,840 --> 00:45:43,400 Speaker 2: the whole HRV conversation. You know, it's really important to 862 00:45:43,400 --> 00:45:45,719 Speaker 2: look at the trends over time, and that's what we 863 00:45:45,800 --> 00:45:46,520 Speaker 2: help provide. 864 00:45:47,080 --> 00:45:50,400 Speaker 3: Yeah, and I think this species is really starting to 865 00:45:50,440 --> 00:45:54,200 Speaker 3: get quite interesting. I mean, you take somebody who's wearing 866 00:45:54,200 --> 00:45:58,399 Speaker 3: a continuous glucose monitor, right, and that if you can 867 00:45:58,560 --> 00:45:59,799 Speaker 3: feed that data up. 868 00:46:00,000 --> 00:46:03,200 Speaker 1: I mean, I have here right here is a continuous 869 00:46:03,280 --> 00:46:06,040 Speaker 1: key tone monitor which is just being. 870 00:46:05,920 --> 00:46:10,360 Speaker 3: Released, right, and I know that there are some early 871 00:46:10,520 --> 00:46:15,799 Speaker 3: research versions of a continuous cortisol monitor, right, which for 872 00:46:15,840 --> 00:46:18,319 Speaker 3: me is a bit of a game changer. Right, if 873 00:46:18,360 --> 00:46:24,520 Speaker 3: you are just constantly measuring these things, and particularly your 874 00:46:24,520 --> 00:46:28,760 Speaker 3: glucose in your cortisol right like and getting that real 875 00:46:28,920 --> 00:46:32,920 Speaker 3: time information like geeze, that upens up a whole new world. 876 00:46:33,080 --> 00:46:36,439 Speaker 3: And I think, you know, we're probably twenty years away 877 00:46:36,480 --> 00:46:40,719 Speaker 3: from people having a chip inserted under their skin that 878 00:46:40,920 --> 00:46:46,160 Speaker 3: is just uploading all of this data into AI, that 879 00:46:46,400 --> 00:46:50,320 Speaker 3: is just you know, just making decisions or tweaks on 880 00:46:50,360 --> 00:46:52,239 Speaker 3: the fly. And this whole idea of a digital twin. 881 00:46:53,080 --> 00:46:55,359 Speaker 3: How far away do you think we are from that? 882 00:46:55,520 --> 00:46:56,239 Speaker 1: In reality? 883 00:46:56,600 --> 00:46:58,920 Speaker 2: I think we're pretty close because again we're seeing it 884 00:46:59,000 --> 00:47:01,600 Speaker 2: right now. I mean I mentioned doctor Galen book Walter earlier. 885 00:47:01,640 --> 00:47:03,640 Speaker 2: You know, he has six of these chips literally on 886 00:47:03,719 --> 00:47:07,000 Speaker 2: his brain on his neural tissue, five in the neo, 887 00:47:07,080 --> 00:47:10,760 Speaker 2: one in the prefrontal. It's right now. So to upload 888 00:47:10,800 --> 00:47:13,440 Speaker 2: information that is different. You know. You can't like you know, 889 00:47:13,600 --> 00:47:16,520 Speaker 2: upload or download jiu jitsu and no jiu jitsu yet, 890 00:47:16,560 --> 00:47:19,920 Speaker 2: you know, like in the matrix. But but the ability 891 00:47:19,960 --> 00:47:23,520 Speaker 2: to measure first, you know, we've made massive progressions there 892 00:47:23,560 --> 00:47:26,800 Speaker 2: down to the single neuron basis, and in the future 893 00:47:26,840 --> 00:47:28,719 Speaker 2: there could be a two way communication for that. So 894 00:47:29,960 --> 00:47:31,880 Speaker 2: it's it's all happening quite quickly. 895 00:47:32,400 --> 00:47:35,200 Speaker 3: It's a it's a very interesting space and the word 896 00:47:35,239 --> 00:47:39,040 Speaker 3: that our kids inhabit is going to be very very interesting. Date, 897 00:47:40,239 --> 00:47:43,479 Speaker 3: So where can people go to find out more about you, 898 00:47:43,520 --> 00:47:44,879 Speaker 3: to find out about. 899 00:47:44,600 --> 00:47:49,360 Speaker 1: Brian one and and these? Brian one available. 900 00:47:48,800 --> 00:47:52,040 Speaker 3: For individuals yet and if not yet, what are you 901 00:47:52,239 --> 00:47:53,000 Speaker 3: planning it? 902 00:47:53,000 --> 00:47:55,879 Speaker 2: It will be this summer, so we'll be opening it up. 903 00:47:55,920 --> 00:48:00,480 Speaker 2: Our goal is to give away a million dementia prevention calls, 904 00:48:01,160 --> 00:48:04,359 Speaker 2: so it'll be completely open. We'll make sure you and 905 00:48:04,400 --> 00:48:08,919 Speaker 2: your listeners are aware. And yeah, right now we're working 906 00:48:08,960 --> 00:48:13,240 Speaker 2: primarily with primarily with longevity clinics, concierge doctors and pepti 907 00:48:13,320 --> 00:48:16,759 Speaker 2: companies and so forth. But later the summer. 908 00:48:16,960 --> 00:48:17,560 Speaker 1: Okay, cool? 909 00:48:17,600 --> 00:48:21,040 Speaker 3: And where can people go to register find out more 910 00:48:21,080 --> 00:48:21,680 Speaker 3: about things? 911 00:48:21,680 --> 00:48:23,000 Speaker 1: Where do we send them? 912 00:48:23,080 --> 00:48:28,000 Speaker 2: So it's brain dot one uh and also peptides dot 913 00:48:28,040 --> 00:48:31,520 Speaker 2: o any one. Yeah, they can find us there and 914 00:48:31,880 --> 00:48:34,239 Speaker 2: happily mentioned your name and we'll put them to the 915 00:48:34,239 --> 00:48:34,879 Speaker 2: front of the list. 916 00:48:35,680 --> 00:48:39,560 Speaker 3: Awesome, great stuff, darnth many thanks and go and enjoy 917 00:48:39,560 --> 00:48:41,000 Speaker 3: your day in Colorado. 918 00:48:41,560 --> 00:48:44,360 Speaker 2: Thank you into nature. Such cheers. 919 00:48:44,680 --> 00:48:45,120 Speaker 1: Good month.