1
00:00:00,120 --> 00:00:04,200
Speaker 1: You might have a small benefit from a regenerative medicine approach,

2
00:00:04,440 --> 00:00:06,600
Speaker 1: but if you're not living clean and your your cells

3
00:00:06,600 --> 00:00:08,480
Speaker 1: are going to flip right back to their bad biology

4
00:00:08,480 --> 00:00:11,120
Speaker 1: in a minute. So we like to optimize people ahead

5
00:00:11,119 --> 00:00:16,919
Speaker 1: of time. Diet, sleep, exercise strategies, supplements, hormone optimization in

6
00:00:16,960 --> 00:00:20,200
Speaker 1: some cases, or mesas all of the above. The better

7
00:00:20,280 --> 00:00:22,640
Speaker 1: your body is receptive to these, the more you'll get

8
00:00:22,640 --> 00:00:30,720
Speaker 1: out of it.

9
00:00:33,479 --> 00:00:36,000
Speaker 2: Hey everyone, before we get into this week's podcast, we

10
00:00:36,080 --> 00:00:39,559
Speaker 2: got a pretty cool announcement to make you are not

11
00:00:39,840 --> 00:00:41,600
Speaker 2: able to connect with us.

12
00:00:41,920 --> 00:00:44,680
Speaker 3: We have a pretty cool little widget that's on the website.

13
00:00:44,800 --> 00:00:49,680
Speaker 3: Just go to poleteilor dot biz Forwards Life podcast and

14
00:00:49,760 --> 00:00:52,240
Speaker 3: near the top of the page you'll see a little

15
00:00:52,479 --> 00:00:55,600
Speaker 3: icon that says send a message to the pole Teeler podcast.

16
00:00:56,040 --> 00:00:58,040
Speaker 2: And so what we can do with that You just

17
00:00:58,080 --> 00:01:01,480
Speaker 2: click on that and then you send an audio message

18
00:01:01,760 --> 00:01:03,240
Speaker 2: and we will get the audio message.

19
00:01:03,320 --> 00:01:04,840
Speaker 3: Now, the first thing I want to do.

20
00:01:04,800 --> 00:01:10,000
Speaker 2: With using it is actually do and ask me anything episode.

21
00:01:10,360 --> 00:01:12,160
Speaker 2: So all you gotta do if you got a question

22
00:01:12,240 --> 00:01:14,720
Speaker 2: that we want me to cover is just go to

23
00:01:14,920 --> 00:01:20,199
Speaker 2: Paul Taylor dot biz Forward Slash podcast and on start

24
00:01:20,240 --> 00:01:23,280
Speaker 2: the recording and then send us a message about what

25
00:01:23,319 --> 00:01:25,640
Speaker 2: you would like me to talk about, and they ask

26
00:01:25,760 --> 00:01:27,039
Speaker 2: me anything and leave your name.

27
00:01:27,440 --> 00:01:29,320
Speaker 3: We will call it out on the show. I'll get

28
00:01:29,360 --> 00:01:31,920
Speaker 3: that all put together. And the other thing you can

29
00:01:31,959 --> 00:01:33,600
Speaker 3: do is just leave us a message about what you

30
00:01:33,720 --> 00:01:36,160
Speaker 3: like about the podcast, what you don't like about the podcast,

31
00:01:36,200 --> 00:01:38,400
Speaker 3: day I talk too much, all of that sort of stuff,

32
00:01:38,680 --> 00:01:41,000
Speaker 3: and just give us some feedback and we will use

33
00:01:41,040 --> 00:01:44,679
Speaker 3: that to continuously improve. So looking forward to hearing from

34
00:01:44,680 --> 00:01:47,320
Speaker 3: you now. I hover the podcast.

35
00:01:46,920 --> 00:01:49,960
Speaker 2: Doctor Jeff Gross, Welcome to the podcast.

36
00:01:50,720 --> 00:01:52,800
Speaker 4: Happy to be here in great meeting you today, Paul,

37
00:01:53,200 --> 00:01:55,200
Speaker 4: and you are as I was just saying, you're the

38
00:01:55,280 --> 00:01:59,760
Speaker 4: second person in two days that I've interviewed from Las Vegas, Nevada.

39
00:02:00,200 --> 00:02:04,800
Speaker 1: It's a new destination center for migration within the US,

40
00:02:05,720 --> 00:02:14,040
Speaker 1: growing tech, growing other industries, not just casinos. So probably

41
00:02:14,800 --> 00:02:18,800
Speaker 1: there's a huge migration of Californians who are trying to

42
00:02:18,880 --> 00:02:24,520
Speaker 1: get away from the disaster of California and Las Vegas

43
00:02:24,560 --> 00:02:28,080
Speaker 1: and Reno, which you add those two together, you have

44
00:02:28,080 --> 00:02:34,800
Speaker 1: probably ninety five percent of the Nevaden population our destinations

45
00:02:35,280 --> 00:02:39,079
Speaker 1: with significant benefits at this time.

46
00:02:39,160 --> 00:02:43,600
Speaker 2: Oh, that's really interesting. So were you an original resident

47
00:02:43,680 --> 00:02:45,799
Speaker 2: of well for many years.

48
00:02:45,880 --> 00:02:49,960
Speaker 1: I was a Californian till about two thousand and fifteen

49
00:02:50,080 --> 00:02:52,880
Speaker 1: or so, and before that, I've lived on the East

50
00:02:52,880 --> 00:02:56,000
Speaker 1: Coast in the Washington DC area. I've lived in the

51
00:02:56,040 --> 00:03:00,920
Speaker 1: Midwest in Ohio and for a couple of years in Albuquerque,

52
00:03:00,960 --> 00:03:01,440
Speaker 1: New Mexico.

53
00:03:01,520 --> 00:03:04,560
Speaker 2: Wow, you've been around. Yeah. I had to tell you what.

54
00:03:04,680 --> 00:03:07,880
Speaker 2: It's almost like those places that you talked about. It's

55
00:03:07,919 --> 00:03:10,639
Speaker 2: almost like different countries in the States.

56
00:03:10,280 --> 00:03:15,440
Speaker 1: Isn't it. It really is. You know, the different geography.

57
00:03:15,760 --> 00:03:18,480
Speaker 1: You know, you are mountains, We've got the coast, and

58
00:03:18,520 --> 00:03:19,520
Speaker 1: now I live in the desert.

59
00:03:19,800 --> 00:03:22,760
Speaker 2: Yeah, and Jesus gets bloody hot. I've been in Las

60
00:03:22,880 --> 00:03:25,520
Speaker 2: Vegas once. It was twenty years ago. Was a death

61
00:03:25,600 --> 00:03:28,119
Speaker 2: valley as well. But just even in Las Vegas, God

62
00:03:28,240 --> 00:03:31,440
Speaker 2: in summer. You know all about it, don't you, Yes, sir,

63
00:03:33,520 --> 00:03:36,000
Speaker 2: so Jeff, we are going to talk about a really

64
00:03:36,320 --> 00:03:41,240
Speaker 2: interesting topic in medicine, and that's stem cell therapies. It's

65
00:03:41,320 --> 00:03:46,640
Speaker 2: obviously not without its controversies, but you are extremely well

66
00:03:46,720 --> 00:03:49,960
Speaker 2: qualified to talk on the subject. I was really interesting

67
00:03:49,960 --> 00:03:54,240
Speaker 2: your background, having a degree in biochemistry and molecular biology,

68
00:03:54,360 --> 00:03:58,080
Speaker 2: then going on to study medicine and then surgery. So

69
00:03:58,280 --> 00:04:00,920
Speaker 2: just give us, give the listeners. There's a little bit

70
00:04:00,920 --> 00:04:05,280
Speaker 2: of a toure of your background and also how you

71
00:04:05,440 --> 00:04:09,120
Speaker 2: brought yourself to this place to looking at stem cell

72
00:04:09,400 --> 00:04:12,440
Speaker 2: therapies and longevity benefits. Particularly, thank you.

73
00:04:12,920 --> 00:04:17,200
Speaker 1: I appreciate the opportunity. I'll start at the at the

74
00:04:17,200 --> 00:04:20,040
Speaker 1: basic level, and I think I mean this in a

75
00:04:20,080 --> 00:04:23,040
Speaker 1: positive way. You'll identify with this. I'm a nerd, so

76
00:04:23,200 --> 00:04:26,280
Speaker 1: when the when the science is interesting, I follow it.

77
00:04:26,400 --> 00:04:30,400
Speaker 1: So so my my undergraduate you know, background is heavily

78
00:04:30,440 --> 00:04:34,960
Speaker 1: into cellular biology and biochemistry. And then you know, in America,

79
00:04:35,040 --> 00:04:38,960
Speaker 1: you go you go right from undergrad typically to medical school,

80
00:04:38,960 --> 00:04:41,880
Speaker 1: which is another four years, and then residency and fellowship

81
00:04:41,880 --> 00:04:44,599
Speaker 1: mind was another seven on top of that. So you

82
00:04:44,680 --> 00:04:48,360
Speaker 1: get so busy and narrowed down the specialty pipeline that

83
00:04:48,720 --> 00:04:52,640
Speaker 1: the molecular biology piece that you know, stimulated your brain

84
00:04:52,720 --> 00:04:55,320
Speaker 1: so much sort of got you know, put on a shelf.

85
00:04:55,960 --> 00:04:59,159
Speaker 1: And I was practicing for this is now my I

86
00:04:59,160 --> 00:05:02,520
Speaker 1: think twenty fifth year or just started my twenty sixth

87
00:05:02,560 --> 00:05:05,799
Speaker 1: year of I'm a neurosurgeon and I have a spine specialty.

88
00:05:05,839 --> 00:05:08,760
Speaker 1: I do a lot of neck and backcare. Second opinions.

89
00:05:08,880 --> 00:05:11,640
Speaker 1: I'd take on the failed cases that were treated elsewhere,

90
00:05:12,240 --> 00:05:15,560
Speaker 1: and I've always tried to, you know, reduce and avoid surgery,

91
00:05:16,160 --> 00:05:19,799
Speaker 1: you know, that being the last option, because we really

92
00:05:19,839 --> 00:05:23,200
Speaker 1: aren't doing anything differently than we were doing in the

93
00:05:23,279 --> 00:05:26,599
Speaker 1: nineteen fifties. Yeah, maybe there's a smaller incision or a

94
00:05:26,640 --> 00:05:30,279
Speaker 1: new gidget or widget or gadget or something, but it's

95
00:05:30,320 --> 00:05:34,360
Speaker 1: the same approach. So it became frustrated over the years,

96
00:05:34,400 --> 00:05:37,240
Speaker 1: and so did my patients, because my patients would come

97
00:05:37,279 --> 00:05:40,840
Speaker 1: in and say, hey, we've tried the physiotherapy, we've tried

98
00:05:40,920 --> 00:05:45,040
Speaker 1: the anti inflammatory medications, we've tried the occupuncture of the chiropractic,

99
00:05:45,080 --> 00:05:49,360
Speaker 1: the physical training, we've tried maybe even some spinal injections,

100
00:05:50,080 --> 00:05:52,359
Speaker 1: but you know those are all temporary. I'm looking for

101
00:05:52,400 --> 00:05:56,119
Speaker 1: something that can help me with this ongoing problem, this pain,

102
00:05:56,240 --> 00:05:59,320
Speaker 1: this whatever pinsioner disc issue. I'd say, well, I guess

103
00:05:59,360 --> 00:06:01,360
Speaker 1: the only thing left talk about is what's on the

104
00:06:01,400 --> 00:06:04,039
Speaker 1: surgical menu. And they'd say, oh, but I'm not ready

105
00:06:04,120 --> 00:06:07,000
Speaker 1: for that. I'd say, great, I'm happy to hear that,

106
00:06:07,480 --> 00:06:09,520
Speaker 1: but I don't have a lot more to offer you

107
00:06:09,960 --> 00:06:13,360
Speaker 1: at this time. And they would say, well, how about lasers?

108
00:06:13,400 --> 00:06:18,160
Speaker 1: How about how about crystals? How about stem cells? And

109
00:06:18,240 --> 00:06:21,560
Speaker 1: you hear it enough times and you you know what,

110
00:06:21,560 --> 00:06:24,440
Speaker 1: what about stem cells? So instead of going to the

111
00:06:24,480 --> 00:06:29,040
Speaker 1: annual you know, spine neurosurgeons meetings, which I had done

112
00:06:29,120 --> 00:06:33,039
Speaker 1: for decades and didn't you know, nothing was changing. I

113
00:06:33,160 --> 00:06:36,880
Speaker 1: decided to open my mind and go back to my roots,

114
00:06:36,880 --> 00:06:40,440
Speaker 1: and I went to stem cell conferences and got re educated.

115
00:06:40,440 --> 00:06:43,200
Speaker 1: This about six years ago, and I did it to

116
00:06:43,279 --> 00:06:46,880
Speaker 1: offer something new, a new tool to my patient's suffering

117
00:06:46,880 --> 00:06:49,680
Speaker 1: from neck and back pain and problems. But it has

118
00:06:49,920 --> 00:06:53,279
Speaker 1: opened up an entire new world for me and people

119
00:06:53,320 --> 00:06:57,560
Speaker 1: who see me in offering a new option, in tapping

120
00:06:57,600 --> 00:07:01,320
Speaker 1: back into our own blueprint of what creates us, what

121
00:07:01,640 --> 00:07:06,320
Speaker 1: heals us, and what maintains us, and using that strategically

122
00:07:06,320 --> 00:07:10,160
Speaker 1: to help repair a problem or help you know, heal

123
00:07:10,320 --> 00:07:15,760
Speaker 1: or regenerate or slow the aging process of physiologically.

124
00:07:14,960 --> 00:07:18,960
Speaker 2: And biologically interesting. I'll tell you what. My daughter is

125
00:07:19,040 --> 00:07:23,320
Speaker 2: going to love this, right she is. She's eighteen and

126
00:07:23,680 --> 00:07:27,720
Speaker 2: about to go to university. And for years she said

127
00:07:27,760 --> 00:07:32,560
Speaker 2: she wanted to study medicine, and we sent her. Last year,

128
00:07:32,720 --> 00:07:37,440
Speaker 2: my wife found this medical internship in Nepal for want

129
00:07:37,440 --> 00:07:40,720
Speaker 2: to be medical students. So off she went for a

130
00:07:40,720 --> 00:07:42,520
Speaker 2: couple of weeks to Nepal with a bunch of other

131
00:07:42,600 --> 00:07:45,800
Speaker 2: want to be medical students. Had a blast. They were

132
00:07:46,200 --> 00:07:51,360
Speaker 2: shadowing Nepalese doctors in remote Nepal, even in surgery, right.

133
00:07:51,520 --> 00:07:55,360
Speaker 2: And she came back. She had a fantastic time. But

134
00:07:55,480 --> 00:07:59,160
Speaker 2: she said to me, Dad, I've realized that everybody that

135
00:07:59,360 --> 00:08:03,480
Speaker 2: was on that course was so passionate about medicine. I've

136
00:08:03,520 --> 00:08:07,080
Speaker 2: realized that my passion is biology. So she wants to

137
00:08:07,080 --> 00:08:10,640
Speaker 2: go and study BioMed and we looked into it and

138
00:08:10,680 --> 00:08:14,559
Speaker 2: there's so many different pathways once you finish your degree

139
00:08:14,600 --> 00:08:18,680
Speaker 2: in BioMed. And I said to her, all that biological engineering,

140
00:08:19,360 --> 00:08:23,160
Speaker 2: like that's the future, right, and I presume stem cell

141
00:08:23,280 --> 00:08:28,280
Speaker 2: therapies come under that broad umbrella of biological engineering.

142
00:08:29,040 --> 00:08:32,840
Speaker 1: Yeah, so there's the biological side of bioengineering. There's the

143
00:08:33,000 --> 00:08:36,760
Speaker 1: tech side of bioengineering. When you think about elon MUSK

144
00:08:36,960 --> 00:08:40,840
Speaker 1: and neurolink and things like that. So and then there

145
00:08:40,920 --> 00:08:44,360
Speaker 1: have to be people that help bridge those So I

146
00:08:44,400 --> 00:08:46,360
Speaker 1: think that there are those faults under that and bro.

147
00:08:46,520 --> 00:08:49,239
Speaker 2: Yeah, awesome. So give us a bit of an overview

148
00:08:49,760 --> 00:08:55,199
Speaker 2: of stem cell therapies and particularly the different types. Right,

149
00:08:55,280 --> 00:08:58,920
Speaker 2: So I know there's embryonic theory potent, there's adult stem

150
00:08:58,960 --> 00:09:02,800
Speaker 2: cell therapy. So just give our listeners who maybe not

151
00:09:03,360 --> 00:09:05,880
Speaker 2: all over this topic, just a bit of a high

152
00:09:05,920 --> 00:09:06,640
Speaker 2: level overview.

153
00:09:06,960 --> 00:09:11,199
Speaker 1: Perfect. So stem cell one oh one is basically it

154
00:09:11,280 --> 00:09:14,559
Speaker 1: comes in different forms. Although we use the phrase stem cells,

155
00:09:15,120 --> 00:09:18,960
Speaker 1: not everything we do involves the use of stem cells.

156
00:09:19,280 --> 00:09:25,000
Speaker 1: For example, there's a lower level regenerative medicine biologic called

157
00:09:25,160 --> 00:09:28,600
Speaker 1: PRP or platelet rich plasma, and it comes in different forms.

158
00:09:28,960 --> 00:09:34,480
Speaker 2: I've had PRP in an achilles injury and I'm currently

159
00:09:34,520 --> 00:09:39,440
Speaker 2: recovering from an acl and the sports medicine doctors suggested PRP, right,

160
00:09:39,720 --> 00:09:41,800
Speaker 2: which is why they spin your own blood and pull

161
00:09:41,880 --> 00:09:44,360
Speaker 2: off the plate reach plasma right.

162
00:09:44,320 --> 00:09:47,680
Speaker 1: Right, So what's in that platelet rich plasma are many

163
00:09:47,720 --> 00:09:51,000
Speaker 1: of the things that stem cells make to help you heal.

164
00:09:51,040 --> 00:09:56,560
Speaker 1: They make proteins, peptides, growth factors, proteins that involve the

165
00:09:56,600 --> 00:10:00,160
Speaker 1: production of collagen when you want to help maintain or

166
00:10:00,160 --> 00:10:02,960
Speaker 1: in your case, heal and injury. And they also put

167
00:10:02,960 --> 00:10:08,679
Speaker 1: off cell signaling bodies called extracellular vesicles or for short, exosomes.

168
00:10:09,120 --> 00:10:12,840
Speaker 1: So there's concentrated from your blood, they get centrifuged and

169
00:10:13,000 --> 00:10:17,200
Speaker 1: separated and re delivered into an area that needs more

170
00:10:17,280 --> 00:10:19,199
Speaker 1: love than it could. You could, your body could give

171
00:10:19,200 --> 00:10:21,640
Speaker 1: it on its own. So that's great, and that's kind

172
00:10:21,640 --> 00:10:25,520
Speaker 1: of a low level offering that's available almost ubiquitously now

173
00:10:25,640 --> 00:10:28,840
Speaker 1: in most of the world. Sometimes it takes a few sessions,

174
00:10:28,920 --> 00:10:31,560
Speaker 1: and it's certainly easy enough and worth trying before you

175
00:10:31,679 --> 00:10:36,320
Speaker 1: undergo something more invasive or major, Right, why not try it? Okay?

176
00:10:36,800 --> 00:10:39,720
Speaker 1: So the next step up from that would be to

177
00:10:39,760 --> 00:10:43,760
Speaker 1: actually deliver stem cells. And stem cells come from two sources,

178
00:10:44,120 --> 00:10:47,040
Speaker 1: and those sources would be an adult. Like you said,

179
00:10:47,080 --> 00:10:50,360
Speaker 1: you can harvest your own stem cells, hopefully with the

180
00:10:50,360 --> 00:10:53,680
Speaker 1: help of a clinician. You know, you don't, don't under yourself.

181
00:10:53,880 --> 00:10:56,840
Speaker 1: But it can come from your bone marra. It could

182
00:10:56,840 --> 00:10:59,400
Speaker 1: come from a you know, fatty tissue and other places,

183
00:10:59,400 --> 00:11:02,280
Speaker 1: but bone is probably the richest source. And you think

184
00:11:02,320 --> 00:11:04,760
Speaker 1: about it. If a sad case, if a child has

185
00:11:04,840 --> 00:11:08,959
Speaker 1: leukemia and they have to undergo a complete chemotherapy, killing

186
00:11:08,960 --> 00:11:11,240
Speaker 1: of the bone marrow and a replacement with a bone

187
00:11:11,280 --> 00:11:14,119
Speaker 1: marrow donor to save that child. That is a replacement

188
00:11:14,200 --> 00:11:17,120
Speaker 1: of that child's stem cells in the bone marrow. So

189
00:11:17,679 --> 00:11:20,920
Speaker 1: now that requires matching because it's such a significant replacement.

190
00:11:21,000 --> 00:11:26,320
Speaker 1: But typically stem cells don't require any matching. They're not rejected.

191
00:11:26,480 --> 00:11:28,679
Speaker 1: Theoretically they can be, but I've never seen it or

192
00:11:28,720 --> 00:11:32,320
Speaker 1: read about it. So they're immunoprivileged. So the immune system says,

193
00:11:32,320 --> 00:11:34,640
Speaker 1: come on in. But the other source is what we

194
00:11:34,679 --> 00:11:37,160
Speaker 1: call perry natal. Pery natal means it comes from the

195
00:11:37,240 --> 00:11:41,800
Speaker 1: afterbirth products from a mother who is, you know, congratulations,

196
00:11:41,840 --> 00:11:44,640
Speaker 1: here's your baby that we just delivered by c section.

197
00:11:45,440 --> 00:11:48,520
Speaker 1: Instead of throwing away the amniotic fluid, the umbilical cord,

198
00:11:48,600 --> 00:11:51,320
Speaker 1: the placenta, can we keep it and use it, you know,

199
00:11:51,400 --> 00:11:53,480
Speaker 1: in medical purposes. That's how that happens. So it's a

200
00:11:53,559 --> 00:11:56,959
Speaker 1: very ethical process. There are myths, you know, of some

201
00:11:57,280 --> 00:12:01,160
Speaker 1: nefarious things happening, you know, but I've ever really seen that.

202
00:12:01,240 --> 00:12:05,120
Speaker 1: I think it's more of a smear campaign that pharmaceutical

203
00:12:05,160 --> 00:12:08,680
Speaker 1: companies and other companies want out there. So that's the

204
00:12:08,720 --> 00:12:11,439
Speaker 1: most active and richest source, Paul. So when you when

205
00:12:11,480 --> 00:12:14,480
Speaker 1: you take your car and you go for an oil change,

206
00:12:15,440 --> 00:12:17,079
Speaker 1: you know, you don't put the old oil back in.

207
00:12:17,160 --> 00:12:22,960
Speaker 1: So I like that young, fresh, bioactive that you know,

208
00:12:23,160 --> 00:12:27,560
Speaker 1: cells and other products that aren't affected by years of

209
00:12:28,160 --> 00:12:32,240
Speaker 1: electromagnetic waves and toxins in the pollutants and whatever. We

210
00:12:32,320 --> 00:12:35,920
Speaker 1: you know, neuro stress from giving yourself the wrong mental

211
00:12:35,960 --> 00:12:36,480
Speaker 1: signals and.

212
00:12:36,480 --> 00:12:39,080
Speaker 2: All that because not Jeff, sorry to interrupt. It is

213
00:12:39,120 --> 00:12:44,000
Speaker 2: one of the mechanisms of aging is stem cell exhaustion,

214
00:12:44,240 --> 00:12:48,840
Speaker 2: isn't it. So that's why those embryonic stale sales are

215
00:12:48,880 --> 00:12:52,199
Speaker 2: those ones that you're talking about. They're cleaner if you

216
00:12:52,440 --> 00:12:54,280
Speaker 2: like stem sales set.

217
00:12:54,480 --> 00:12:57,040
Speaker 1: Yeah, they're the most active because they have not been

218
00:12:57,720 --> 00:13:00,800
Speaker 1: ruined by the world in the environment, and they're as

219
00:13:00,920 --> 00:13:04,319
Speaker 1: naive and active as they come. Now we call these

220
00:13:04,360 --> 00:13:08,520
Speaker 1: perinatal embryonic is actually involved in the embryo making a

221
00:13:08,559 --> 00:13:13,600
Speaker 1: feed in and you can induce certain these stem cells

222
00:13:13,600 --> 00:13:16,640
Speaker 1: at the time of a birth or an adult back

223
00:13:16,760 --> 00:13:20,240
Speaker 1: into the embryonic state. There's a Nobel prize about how

224
00:13:20,280 --> 00:13:22,960
Speaker 1: to do that. And those cells have even more power

225
00:13:23,280 --> 00:13:25,319
Speaker 1: and we're learning how to harness them. And only very

226
00:13:25,360 --> 00:13:28,680
Speaker 1: certain circumstances are those in use in the world, and

227
00:13:28,720 --> 00:13:31,680
Speaker 1: here in the us A they are. They are under

228
00:13:31,720 --> 00:13:35,319
Speaker 1: research and they're called you know, induced pluripotent stem cells,

229
00:13:35,360 --> 00:13:38,280
Speaker 1: which are more of an embryonic state. Now, those are

230
00:13:38,320 --> 00:13:40,640
Speaker 1: the cells someday that are going to help us regrow

231
00:13:40,679 --> 00:13:43,920
Speaker 1: a finger or a limb or an organ better than

232
00:13:44,400 --> 00:13:45,360
Speaker 1: what we have right now?

233
00:13:45,600 --> 00:13:47,760
Speaker 2: Are they some of the ones that you can you

234
00:13:47,760 --> 00:13:54,680
Speaker 2: hear some people go into Mexico to get done or yeah, okay, cool, Yeah, So.

235
00:13:54,800 --> 00:13:56,720
Speaker 1: Let's take let's take that comment for a minute and

236
00:13:56,720 --> 00:13:59,240
Speaker 1: build on it. In the US we're actually late to

237
00:13:59,280 --> 00:14:03,280
Speaker 1: the game. Europe and Asia are way ahead in the

238
00:14:03,360 --> 00:14:07,840
Speaker 1: regenerative medicine field, and most of the professional athletes who

239
00:14:07,920 --> 00:14:10,760
Speaker 1: needed some type of stem cell based treatment would go

240
00:14:10,800 --> 00:14:14,480
Speaker 1: to Europe for decades, right, you know, Tiger Woods, Peyton

241
00:14:14,520 --> 00:14:17,280
Speaker 1: manning some of these players. And if you read the

242
00:14:17,320 --> 00:14:19,880
Speaker 1: Asian literature, and a lot of the good clinical medicine

243
00:14:20,120 --> 00:14:23,359
Speaker 1: that we follow here in US are based on studies

244
00:14:23,680 --> 00:14:26,200
Speaker 1: with years of follow up that are done in these

245
00:14:26,240 --> 00:14:31,080
Speaker 1: other countries. Mexico and Central America is a little less regulated,

246
00:14:31,200 --> 00:14:34,760
Speaker 1: but they also have access to not only we'll call

247
00:14:34,800 --> 00:14:38,120
Speaker 1: them multipotent stem cells, which are usually the ones at

248
00:14:38,160 --> 00:14:41,360
Speaker 1: birth or thereafter, but they do, like you said, have

249
00:14:41,440 --> 00:14:46,000
Speaker 1: access to these induced embryonic state stem cells. So that's

250
00:14:46,080 --> 00:14:49,520
Speaker 1: a growing idea. And then back to the underlying question

251
00:14:49,600 --> 00:14:53,800
Speaker 1: here is there's a third level of regenerative medicine, and

252
00:14:53,840 --> 00:14:58,280
Speaker 1: that's based on these cell signaling particles called extracellular vesicles

253
00:14:58,360 --> 00:15:01,800
Speaker 1: or exosomes that stems and in fact all cells produce,

254
00:15:02,120 --> 00:15:06,880
Speaker 1: but the actual work that one's own body does, that

255
00:15:07,000 --> 00:15:10,200
Speaker 1: needs a little re encouragement to behave at a more

256
00:15:10,200 --> 00:15:15,880
Speaker 1: youthful restorative you know, anti inflammatory status comes from these

257
00:15:15,880 --> 00:15:19,800
Speaker 1: stem cells signaling. So, Paul, if I gave you in

258
00:15:19,840 --> 00:15:22,840
Speaker 1: your vein a dose of stem cells in ten to

259
00:15:22,880 --> 00:15:25,920
Speaker 1: fourteen days, they be gone, but the benefits would last

260
00:15:26,400 --> 00:15:29,080
Speaker 1: weeks and months, if not some of the benefits permanent.

261
00:15:29,480 --> 00:15:32,720
Speaker 1: Why is that because those stem cells have produced and

262
00:15:32,800 --> 00:15:37,640
Speaker 1: delivered these exosomes full of heat shock proteins and peptides

263
00:15:37,680 --> 00:15:41,360
Speaker 1: and growth factors and re education and encouragement to their

264
00:15:41,400 --> 00:15:44,440
Speaker 1: neighboring cells of your body that does the actual work.

265
00:15:44,720 --> 00:15:46,640
Speaker 1: So we're now skipping ahead of stem cells. So the

266
00:15:46,760 --> 00:15:51,720
Speaker 1: latest and greatest are these stem cells derived exosomes, And

267
00:15:51,800 --> 00:15:56,840
Speaker 1: they have advantages. They're less costly, they penetrate the body better,

268
00:15:57,000 --> 00:15:59,560
Speaker 1: they can cross the blood brain barrier and get into

269
00:15:59,560 --> 00:16:03,280
Speaker 1: the brain. They are also more easily handled and stored

270
00:16:03,880 --> 00:16:06,760
Speaker 1: and they don't have anyone else's DNA and some people

271
00:16:06,880 --> 00:16:09,720
Speaker 1: like that, and these are just generic. We have some

272
00:16:09,800 --> 00:16:13,080
Speaker 1: designer ones coming that are available in China that I

273
00:16:13,120 --> 00:16:16,840
Speaker 1: think will be fantastic. You know, some for helping build

274
00:16:16,920 --> 00:16:20,560
Speaker 1: muscle mass, which is correlated with longevity, helping improve bondency.

275
00:16:21,000 --> 00:16:24,720
Speaker 1: Some are from the immune cells that help identify and

276
00:16:24,760 --> 00:16:28,480
Speaker 1: remove abnormal cells like sinessence cells and cancer cells. So

277
00:16:28,720 --> 00:16:30,560
Speaker 1: we are just at the forefront.

278
00:16:30,920 --> 00:16:35,440
Speaker 2: Interest interesting that the exosomes are really coming to the

279
00:16:35,480 --> 00:16:39,040
Speaker 2: forefront eye. I did interview a professor who's in the

280
00:16:39,080 --> 00:16:42,200
Speaker 2: area of exosomes and we were talking about the interaction

281
00:16:42,400 --> 00:16:46,640
Speaker 2: with miokinds produced in muscle yes and exosomes and how

282
00:16:46,680 --> 00:16:47,680
Speaker 2: they work together.

283
00:16:47,920 --> 00:16:52,440
Speaker 1: Yeah, you're singing my song there. Myokinds are amazing. And

284
00:16:52,480 --> 00:16:56,400
Speaker 1: one way to stimulate your own stem cells is move exercise.

285
00:16:56,560 --> 00:16:59,360
Speaker 1: You know, we call this hormesis where you give the

286
00:16:59,400 --> 00:17:02,800
Speaker 1: body a little bit the stress to build resilience when

287
00:17:02,840 --> 00:17:05,280
Speaker 1: your body, you know, needs it, and that helps release

288
00:17:05,720 --> 00:17:09,080
Speaker 1: stem cells. It helps clear out zombies and essence cells

289
00:17:09,119 --> 00:17:12,040
Speaker 1: which are taking up space and resources but not doing

290
00:17:12,080 --> 00:17:15,560
Speaker 1: any good, so that you have a younger population of cells.

291
00:17:15,560 --> 00:17:17,639
Speaker 1: And when you do you have a younger you know,

292
00:17:18,000 --> 00:17:21,479
Speaker 1: physiologic body and this can be measured in biological age

293
00:17:21,520 --> 00:17:26,840
Speaker 1: tests through certain markers and probably with the biofitness bioage

294
00:17:26,840 --> 00:17:28,000
Speaker 1: fitness testing that you do.

295
00:17:28,200 --> 00:17:33,240
Speaker 2: So yeah, yes, interesting and very interesting that you mentioned hormesis.

296
00:17:33,320 --> 00:17:35,919
Speaker 2: We could go down that rabbit hole, which we won't,

297
00:17:36,200 --> 00:17:39,760
Speaker 2: and I'm about to start a lab with Professor Grant

298
00:17:39,760 --> 00:17:43,480
Speaker 2: Scofield called the Hormesis Lab, love it, where we are

299
00:17:43,600 --> 00:17:48,720
Speaker 2: looking at hormetic interventions to enhance health span. Right, so

300
00:17:48,720 --> 00:17:52,400
Speaker 2: it's his exercise saun a cold exposure. You know, these

301
00:17:52,600 --> 00:17:58,480
Speaker 2: small It's amazing how the body adapts to small doses

302
00:17:58,520 --> 00:18:03,560
Speaker 2: of stressors, right right. It's through the signaling, the cellular

303
00:18:03,680 --> 00:18:07,080
Speaker 2: signaling that all of this takes place, right, which is

304
00:18:07,480 --> 00:18:11,000
Speaker 2: why you're obviously so interested in this area. So talk

305
00:18:11,119 --> 00:18:15,840
Speaker 2: to you about some of the use kisses, both currently

306
00:18:16,119 --> 00:18:19,120
Speaker 2: the stuff that you do and that others are doing

307
00:18:19,119 --> 00:18:21,800
Speaker 2: in those use cases, and then we'll come back to

308
00:18:21,840 --> 00:18:24,399
Speaker 2: some potential future use cases. But let's give us the

309
00:18:24,440 --> 00:18:25,720
Speaker 2: state of play right now.

310
00:18:26,200 --> 00:18:30,560
Speaker 1: Right, So, the low hanging fruit all is muscular skeletal

311
00:18:31,119 --> 00:18:38,640
Speaker 1: structural things like joints, particularly degenerated joints. Loss of cartilage, osteoarthritis,

312
00:18:38,720 --> 00:18:40,960
Speaker 1: or bone on bone. Those are all part of the

313
00:18:41,000 --> 00:18:45,160
Speaker 1: same package. We follow a French protocol whereby the fifteen

314
00:18:45,240 --> 00:18:48,840
Speaker 1: year follow up clinical data was published a few years back,

315
00:18:48,880 --> 00:18:51,919
Speaker 1: so they're probably ready to publish their twenty year in

316
00:18:52,040 --> 00:18:55,399
Speaker 1: which at that time they only had stem cells. Exosomes

317
00:18:55,440 --> 00:18:58,200
Speaker 1: are only available in the last five or five or

318
00:18:58,200 --> 00:19:00,560
Speaker 1: eight years, depending on what part of the world. So

319
00:19:00,720 --> 00:19:06,040
Speaker 1: they injected stem cells into patients knees who were already

320
00:19:06,080 --> 00:19:10,800
Speaker 1: recommended a knee replacement surgery. So they took patients they said,

321
00:19:10,880 --> 00:19:12,840
Speaker 1: you need to need replacement, Well, wait a minute, would

322
00:19:12,880 --> 00:19:14,879
Speaker 1: you like to join our study to try not to

323
00:19:14,920 --> 00:19:17,440
Speaker 1: have one? So they had no problem signing up people.

324
00:19:17,920 --> 00:19:21,439
Speaker 1: And this is doctor Philippe Hernegeau. I probably mispronounced that,

325
00:19:21,600 --> 00:19:27,600
Speaker 1: but University of Paris East, an orthopedic surgeon who published this,

326
00:19:27,640 --> 00:19:30,320
Speaker 1: and they did half the patients they injected into the

327
00:19:30,359 --> 00:19:33,639
Speaker 1: cartilage of the joint, and we use the word intra

328
00:19:33,920 --> 00:19:36,840
Speaker 1: articular when we do that, and half the patients got

329
00:19:36,840 --> 00:19:40,280
Speaker 1: it into the bone edge just above them below the joint,

330
00:19:41,040 --> 00:19:45,000
Speaker 1: which is called the subchondri bone. It's an old leftover

331
00:19:45,080 --> 00:19:46,880
Speaker 1: part of the growth plate. But you know it lives

332
00:19:46,880 --> 00:19:52,959
Speaker 1: in there. The cells that produce cartilage, they're called chondrocytes,

333
00:19:52,960 --> 00:19:57,280
Speaker 1: and those cells are the cells that produced that cartilage,

334
00:19:57,560 --> 00:20:01,440
Speaker 1: that meniscus, that acl in the first place. And they

335
00:20:01,560 --> 00:20:05,320
Speaker 1: found over fifteen years that the best results and longest

336
00:20:05,400 --> 00:20:08,760
Speaker 1: lasting results come from and injecting the bone edges. So

337
00:20:08,840 --> 00:20:11,760
Speaker 1: that's what we do. You might say, wait a minute,

338
00:20:11,600 --> 00:20:14,560
Speaker 1: the bone injection. That sounds painful. Well, we do give

339
00:20:14,600 --> 00:20:18,399
Speaker 1: a little twilight sedation for that, and it's usually a

340
00:20:18,440 --> 00:20:21,880
Speaker 1: one and done in most cases, and there's no downtime.

341
00:20:21,920 --> 00:20:25,040
Speaker 1: You can go right back to sports. You'd be sore

342
00:20:25,119 --> 00:20:27,679
Speaker 1: for a week, but what have you go back to

343
00:20:27,680 --> 00:20:30,200
Speaker 1: your thing. And we've seen, you know, months down the line,

344
00:20:30,240 --> 00:20:32,679
Speaker 1: we have some patients we've done some MRIs after the

345
00:20:32,720 --> 00:20:38,520
Speaker 1: fact and we've seen restoration in cartilage thickness and improvement

346
00:20:38,680 --> 00:20:41,240
Speaker 1: that goes with that in pain and improvement and functions.

347
00:20:41,320 --> 00:20:45,080
Speaker 1: So we are seeing a reversal and a regeneration of

348
00:20:45,119 --> 00:20:47,320
Speaker 1: the cartilage of the joint because we're putting in a

349
00:20:47,440 --> 00:20:51,040
Speaker 1: factory order to the factory for some new cartilage in

350
00:20:51,080 --> 00:20:53,560
Speaker 1: a person whose body, like you said, is stem cells

351
00:20:53,560 --> 00:20:56,040
Speaker 1: are exhausted. Otherwise they would have healed it themselves already.

352
00:20:56,800 --> 00:21:01,359
Speaker 2: Yeah. That for somebody like you used to doing surgery.

353
00:21:01,640 --> 00:21:05,600
Speaker 2: When you see that and done those operations, that must

354
00:21:05,640 --> 00:21:06,440
Speaker 2: just blow your mind.

355
00:21:06,560 --> 00:21:10,520
Speaker 1: It's a renewal of my interest in clinical medicine because

356
00:21:10,520 --> 00:21:13,040
Speaker 1: I was in a rut doing these same surgeries over

357
00:21:13,080 --> 00:21:15,680
Speaker 1: and over again, or trying to keep people away from them.

358
00:21:15,720 --> 00:21:18,920
Speaker 1: You know, here's a very simple way that we can

359
00:21:18,960 --> 00:21:21,959
Speaker 1: help people without surgery, not in every case, but in

360
00:21:22,000 --> 00:21:25,399
Speaker 1: many cases, or maybe push out the surgery because there

361
00:21:25,400 --> 00:21:27,880
Speaker 1: are always new things coming, push it out ten years

362
00:21:27,920 --> 00:21:29,879
Speaker 1: and by then we have another stem cell solution. So

363
00:21:30,880 --> 00:21:33,399
Speaker 1: it's been wonderful and remarkable. I wish I had this

364
00:21:33,440 --> 00:21:34,639
Speaker 1: tool my entire career.

365
00:21:35,119 --> 00:21:39,040
Speaker 2: So knaseed hips would obviously lend themselves to this very

366
00:21:39,160 --> 00:21:42,160
Speaker 2: very strongly. And the amount of knee and hip replacements

367
00:21:42,160 --> 00:21:45,920
Speaker 2: that are to is just ridiculous. What about the spine

368
00:21:46,000 --> 00:21:48,679
Speaker 2: as well, because I know, you know, in extreme cases

369
00:21:48,720 --> 00:21:52,960
Speaker 2: when people have long term spinal issues, sometimes they get

370
00:21:53,080 --> 00:21:57,960
Speaker 2: spinal fusion, which my understanding has a hit rate of

371
00:21:58,080 --> 00:22:01,199
Speaker 2: around our success rate of around fifty percent. I think

372
00:22:01,240 --> 00:22:05,800
Speaker 2: there was some Harvard doctor who did placebo operations and

373
00:22:05,960 --> 00:22:08,600
Speaker 2: got similar results from.

374
00:22:08,920 --> 00:22:11,560
Speaker 1: I don't know who would sign up for the placebo spine.

375
00:22:11,640 --> 00:22:15,440
Speaker 2: Yeah, no exactly, but has it got use cases there

376
00:22:15,520 --> 00:22:17,920
Speaker 2: in spinal difficulties as well.

377
00:22:18,119 --> 00:22:21,399
Speaker 1: Yeah. Now, the key to understanding the spine, because it's

378
00:22:21,440 --> 00:22:24,680
Speaker 1: a complex structure, is to know exactly where the pain

379
00:22:24,760 --> 00:22:27,200
Speaker 1: is coming from. Is it coming from a disk source,

380
00:22:27,320 --> 00:22:29,520
Speaker 1: Is it coming from a facet joint, which are the

381
00:22:29,560 --> 00:22:31,600
Speaker 1: joints in the back of the spine. Is it coming

382
00:22:31,640 --> 00:22:34,879
Speaker 1: from both or something else, or has the spine become

383
00:22:34,960 --> 00:22:39,080
Speaker 1: debilitated whether aren't the muscular support. So we have to

384
00:22:39,080 --> 00:22:41,280
Speaker 1: come to an understanding, and we have to you know,

385
00:22:41,520 --> 00:22:44,720
Speaker 1: practically test that sometimes with some numbing shots to see

386
00:22:44,760 --> 00:22:49,359
Speaker 1: what temporarily resolves pain. And based on that, based on

387
00:22:49,400 --> 00:22:52,560
Speaker 1: a good exam, based on some high quality MR images

388
00:22:52,600 --> 00:22:55,040
Speaker 1: done in a very special way, we put all that

389
00:22:55,080 --> 00:22:58,399
Speaker 1: information together and come with some kind of plan. Not

390
00:22:58,560 --> 00:23:01,800
Speaker 1: everyone we can. If we can treat part of it

391
00:23:01,920 --> 00:23:04,640
Speaker 1: and that's good enough to keep someone away from surgery,

392
00:23:04,840 --> 00:23:07,480
Speaker 1: that could be something we do. So we treat plenty

393
00:23:07,480 --> 00:23:11,760
Speaker 1: of spines. Spines take longer, usually nine months or more

394
00:23:12,080 --> 00:23:15,680
Speaker 1: to improve. This is my observation. We'll collect all these

395
00:23:15,720 --> 00:23:19,239
Speaker 1: someday and publish them but I'm not. I don't have

396
00:23:19,320 --> 00:23:22,640
Speaker 1: a reason why that is, but except that spinal disc

397
00:23:22,760 --> 00:23:25,760
Speaker 1: isn't like a nimaniscus. Spinal disc has two different forms

398
00:23:25,760 --> 00:23:28,600
Speaker 1: of cartilage, and I think that's part of the reason.

399
00:23:28,640 --> 00:23:30,800
Speaker 1: So we're learning more about it all the time.

400
00:23:31,080 --> 00:23:34,919
Speaker 2: Yeah, that's definitely more complicated than nas and hips, and

401
00:23:34,960 --> 00:23:41,240
Speaker 2: so let's not talk about just overall the difference between

402
00:23:41,760 --> 00:23:47,880
Speaker 2: the benefits of these regenerative treatments versus the typical medical approaches.

403
00:23:48,440 --> 00:23:53,840
Speaker 2: So you've mentioned their return to daily activities, that's one benefit.

404
00:23:54,240 --> 00:23:58,000
Speaker 2: What other benefits d you see other than like avoiding surgery? Right,

405
00:23:58,040 --> 00:24:01,760
Speaker 2: So I had a actually, let's take I recently, a

406
00:24:01,800 --> 00:24:06,360
Speaker 2: couple of years ago, had a hip resurfacing, right, and

407
00:24:06,480 --> 00:24:09,520
Speaker 2: the rehab took quite a while. It took quite a

408
00:24:09,560 --> 00:24:11,480
Speaker 2: few months. I'm not a couple of years, and the

409
00:24:11,520 --> 00:24:15,840
Speaker 2: hip feels fantastic. But that ain't gonna last forever, right,

410
00:24:15,920 --> 00:24:19,200
Speaker 2: I'm gonna have to go and revisit that at some stage.

411
00:24:19,600 --> 00:24:23,680
Speaker 2: So talk about what some of the other benefits would

412
00:24:23,720 --> 00:24:25,840
Speaker 2: be other than quicker recovery.

413
00:24:26,040 --> 00:24:29,920
Speaker 1: Well, besides the you know, the quicker recovery, least, lesser invasion,

414
00:24:30,000 --> 00:24:33,320
Speaker 1: less risk of infection, and less. Yeah, you don't have

415
00:24:33,359 --> 00:24:35,240
Speaker 1: the long recovery, you don't need a bunch of pain

416
00:24:35,280 --> 00:24:40,320
Speaker 1: medicines after, and potentially a reduced costs because if you

417
00:24:40,320 --> 00:24:42,760
Speaker 1: you know, if you're someone who has to recover from

418
00:24:42,800 --> 00:24:46,720
Speaker 1: a surgery and miswork, miss income, you know, pain and

419
00:24:46,760 --> 00:24:49,080
Speaker 1: suffering that goes with that. I mean, at the end

420
00:24:49,080 --> 00:24:52,120
Speaker 1: of the day, these procedures are are more affordable, especially

421
00:24:52,200 --> 00:24:56,200
Speaker 1: using the stem cell derived exosomes and related growth factors.

422
00:24:56,200 --> 00:24:59,960
Speaker 1: They're they're less costly than stem cells in some cases.

423
00:25:00,119 --> 00:25:02,280
Speaker 1: For example, if we did a knee and it required

424
00:25:02,280 --> 00:25:05,240
Speaker 1: a dose above and a dose below, usually something like

425
00:25:05,280 --> 00:25:08,200
Speaker 1: that is in the ten to twelve thousand dollars US

426
00:25:08,840 --> 00:25:13,560
Speaker 1: dollar range includes everything. So that's you know, you look

427
00:25:13,600 --> 00:25:17,240
Speaker 1: at a you know, a knee surgery depending on what

428
00:25:17,400 --> 00:25:19,560
Speaker 1: your health insurance may or may not cover. Here in

429
00:25:19,960 --> 00:25:22,760
Speaker 1: the US, it's complex. They have deductibles you have to meet,

430
00:25:22,800 --> 00:25:25,840
Speaker 1: and cope's and things. You may be saving money doing

431
00:25:25,920 --> 00:25:27,479
Speaker 1: the regenerative medicine approach.

432
00:25:28,000 --> 00:25:30,800
Speaker 2: Yeah, and then the other thing is that you don't

433
00:25:30,840 --> 00:25:36,400
Speaker 2: have any foreign bodies inside. You read yesterday, Actually some

434
00:25:36,560 --> 00:25:41,200
Speaker 2: cases in the UK were hip joints that they had

435
00:25:41,240 --> 00:25:46,560
Speaker 2: put in were actually leaking out toxins and causing really

436
00:25:46,680 --> 00:25:49,440
Speaker 2: poor health. I remember, they're going to not going shit,

437
00:25:49,520 --> 00:25:53,720
Speaker 2: what type of joint was that. I've I've got obviously

438
00:25:53,800 --> 00:25:56,600
Speaker 2: foreign bodies in there. I've got metal in my body.

439
00:25:57,080 --> 00:26:00,320
Speaker 2: You're not introducing foreign bodies in there. Now, generally these

440
00:26:00,320 --> 00:26:01,960
Speaker 2: things are pretty See if I think that was just

441
00:26:02,119 --> 00:26:04,879
Speaker 2: one type of hip joint that had it had a

442
00:26:04,920 --> 00:26:08,480
Speaker 2: couple of different joins and that was the issue with it.

443
00:26:08,520 --> 00:26:12,080
Speaker 2: But that's got to be a benefit if you're not

444
00:26:12,400 --> 00:26:15,000
Speaker 2: introducing foreign substances into the body.

445
00:26:15,200 --> 00:26:17,840
Speaker 1: Oh, absolutely true. You know, all of those things have

446
00:26:17,960 --> 00:26:23,200
Speaker 1: frictional wear and and material you know, failure over time.

447
00:26:23,440 --> 00:26:26,840
Speaker 1: And the other benefit here with going in a regenerative

448
00:26:26,920 --> 00:26:30,600
Speaker 1: injectional route is you know, you talk about like you're resurfacing.

449
00:26:30,720 --> 00:26:34,240
Speaker 1: Anytime you go into a joint to trim some cartilage

450
00:26:34,400 --> 00:26:37,240
Speaker 1: or you know, try to help in a regular surface

451
00:26:37,320 --> 00:26:41,320
Speaker 1: become more regular so it moves smoother. You're actually increasing

452
00:26:42,640 --> 00:26:46,639
Speaker 1: the development of osteoarthritis. You know, some doctors just use

453
00:26:46,720 --> 00:26:49,480
Speaker 1: the word arthritis in that joint. Over time, Yes, you

454
00:26:49,560 --> 00:26:52,639
Speaker 1: have benefit for a while, but you're accelerating the process.

455
00:26:52,880 --> 00:26:55,560
Speaker 1: So we seek to do the reverse of that. Right,

456
00:26:55,880 --> 00:26:58,480
Speaker 1: So we would take someone like you, and I would

457
00:26:58,480 --> 00:27:00,240
Speaker 1: have loved to have you. You know, at the time

458
00:27:00,280 --> 00:27:04,160
Speaker 1: of your resurfacing inject you know, the surface, the edge

459
00:27:04,200 --> 00:27:05,960
Speaker 1: of the bone and the ball of your hip joint

460
00:27:06,040 --> 00:27:09,480
Speaker 1: and maybe even also the receptor part the cup of

461
00:27:09,520 --> 00:27:12,679
Speaker 1: the joint with the regenerative biologics. You're still candidate, but

462
00:27:12,960 --> 00:27:16,320
Speaker 1: that would be what we would do to try to improve. Now,

463
00:27:17,200 --> 00:27:18,640
Speaker 1: now that you have a nice shape in your hip,

464
00:27:18,680 --> 00:27:21,600
Speaker 1: we want to help you produce and maintain that joint,

465
00:27:21,600 --> 00:27:25,280
Speaker 1: better lubricate it, better produce the proteins and growth factors

466
00:27:25,320 --> 00:27:28,480
Speaker 1: and the collagen and the cartilage in there to help

467
00:27:28,520 --> 00:27:30,320
Speaker 1: restore interesting.

468
00:27:30,560 --> 00:27:32,360
Speaker 2: I think when the other hips roady, I'll be coming

469
00:27:32,400 --> 00:27:32,720
Speaker 2: to you.

470
00:27:34,480 --> 00:27:34,920
Speaker 1: Perfect.

471
00:27:35,520 --> 00:27:38,560
Speaker 2: So let's talk about your journey and when you were

472
00:27:38,680 --> 00:27:43,159
Speaker 2: shifting across from the traditional stuff. What were some of

473
00:27:43,200 --> 00:27:44,920
Speaker 2: the challenges that you went through.

474
00:27:45,119 --> 00:27:48,240
Speaker 1: Well, some people, you know, are completely dependent on their

475
00:27:48,240 --> 00:27:50,959
Speaker 1: health insurance here in the US, and they don't have

476
00:27:51,000 --> 00:27:54,919
Speaker 1: the resources, even though these are reasonably affordable compared to

477
00:27:54,960 --> 00:27:58,639
Speaker 1: most things, so some people have trouble with that. Luckily,

478
00:27:58,720 --> 00:28:01,720
Speaker 1: we've been able to work with some charitable programs. There's

479
00:28:01,720 --> 00:28:04,960
Speaker 1: a there's a Veterans group, we support being able to

480
00:28:04,960 --> 00:28:07,800
Speaker 1: provide some you know, pro bono care. There there are

481
00:28:07,800 --> 00:28:10,520
Speaker 1: some people who think that they're that these procedures are

482
00:28:10,560 --> 00:28:14,199
Speaker 1: illegal because we are not allowed in the US to

483
00:28:14,240 --> 00:28:19,080
Speaker 1: make marketing claims that we're curing or treating anything. Certainly,

484
00:28:19,119 --> 00:28:22,880
Speaker 1: doctors can't give guarantees about anything, but we're very cautious

485
00:28:22,920 --> 00:28:25,000
Speaker 1: not to make claims. So anything we say here today,

486
00:28:25,320 --> 00:28:29,000
Speaker 1: Paul is for educational purposes and and I'm allowed to

487
00:28:29,320 --> 00:28:33,600
Speaker 1: speak to anecdotal results, which I have, and but I'm

488
00:28:33,640 --> 00:28:35,919
Speaker 1: not allowed to make a claim. So despite what you

489
00:28:35,960 --> 00:28:38,560
Speaker 1: think in the US about free speech, it's uh, there

490
00:28:38,560 --> 00:28:39,400
Speaker 1: are limitations.

491
00:28:39,880 --> 00:28:43,400
Speaker 2: Is that different to you doing surgery? Could you make

492
00:28:43,560 --> 00:28:45,560
Speaker 2: our ours? That? Is that the same across the board

493
00:28:45,600 --> 00:28:50,200
Speaker 2: that you can't make claims. Are they particularly tight on

494
00:28:50,480 --> 00:28:51,640
Speaker 2: stem cell therapies?

495
00:28:51,920 --> 00:28:54,280
Speaker 1: Well, I think I think the stem cell therapies are

496
00:28:54,320 --> 00:28:58,600
Speaker 1: an exciting area for governmental regulation. I don't know if

497
00:28:58,600 --> 00:29:01,760
Speaker 1: there are any tighter but doc aren't supposed to make

498
00:29:01,800 --> 00:29:06,720
Speaker 1: claims about anything that hasn't been given approval for said claims.

499
00:29:07,320 --> 00:29:12,520
Speaker 1: And these these are usually drugs and devices. So a

500
00:29:12,840 --> 00:29:17,400
Speaker 1: surgery is unregulated by the FDA, by the government regenerative

501
00:29:17,440 --> 00:29:21,560
Speaker 1: medicine is regulated and there are no yet any approvals.

502
00:29:21,600 --> 00:29:24,920
Speaker 1: There are no disapprovals. Just so we're clear. It's sort

503
00:29:24,960 --> 00:29:27,240
Speaker 1: of this in limbo state.

504
00:29:27,320 --> 00:29:30,320
Speaker 2: Right, got it? Interesting type rope that you've got to

505
00:29:30,360 --> 00:29:34,640
Speaker 2: walk in. And then let's just talk about other potential

506
00:29:34,800 --> 00:29:37,760
Speaker 2: use cases. So you're in a particular area, but I

507
00:29:37,920 --> 00:29:43,280
Speaker 2: have seen the some potential for stem cell therapies for

508
00:29:43,920 --> 00:29:49,120
Speaker 2: like diabetes, neurodegenerative disorders, those sorts of things. Get just

509
00:29:49,160 --> 00:29:52,360
Speaker 2: give our listeners. I know it's not your particular specialization,

510
00:29:52,440 --> 00:29:55,680
Speaker 2: but just you know, what's the potential here.

511
00:29:55,840 --> 00:29:57,680
Speaker 1: Yeah, no, we we do some of this too. You

512
00:29:57,720 --> 00:30:00,360
Speaker 1: can you cannot be in the regenerative medicine fel to

513
00:30:00,360 --> 00:30:04,400
Speaker 1: not you know, easily expand into other areas. But we

514
00:30:04,520 --> 00:30:08,760
Speaker 1: have IV treatments for people who have any type of

515
00:30:09,000 --> 00:30:13,239
Speaker 1: inflammatory burden. Inflammatory is a code word for you know,

516
00:30:13,480 --> 00:30:16,920
Speaker 1: degeneration of the cell, the tissues the body, which is

517
00:30:16,960 --> 00:30:20,680
Speaker 1: another theory of aging, right, this whole inflammating. So anything

518
00:30:20,720 --> 00:30:25,320
Speaker 1: we can do to slow, reverse reverse the inflammatory activities

519
00:30:25,320 --> 00:30:28,680
Speaker 1: inside of a cell, we call that cellular metabolism and

520
00:30:28,680 --> 00:30:31,479
Speaker 1: flip it into an anti inflammatory mode, which is more

521
00:30:31,480 --> 00:30:37,640
Speaker 1: of an optimal mode. And optimal mode heals better, restores,

522
00:30:38,240 --> 00:30:42,000
Speaker 1: maintains the adult bodies. So that's what we're seeking. So

523
00:30:42,040 --> 00:30:45,520
Speaker 1: we do IV for people with organ damage with type

524
00:30:45,520 --> 00:30:49,040
Speaker 1: two diabetes that has an inflammatory component. Most of the

525
00:30:49,080 --> 00:30:54,080
Speaker 1: diseases of aging are diseases of inflammation. Right coronary artery disease,

526
00:30:54,200 --> 00:30:58,440
Speaker 1: have the plaques, has an inflammatory component, Alzheimer's disease, misfolded

527
00:30:58,480 --> 00:31:02,440
Speaker 1: proteins has an inflammatory component. We look at osteoarthritis we've

528
00:31:02,440 --> 00:31:05,440
Speaker 1: talked about of course has a huge inflammatory component. And

529
00:31:05,480 --> 00:31:09,800
Speaker 1: then people with inflammatory issues in general like autoimmune you know,

530
00:31:10,040 --> 00:31:17,080
Speaker 1: flammatory bowel problems, exzema, psoriasis, other arthritis type problems, thyroid problems,

531
00:31:17,280 --> 00:31:19,840
Speaker 1: and certain infections that are known to have a very

532
00:31:20,000 --> 00:31:25,000
Speaker 1: hyper inflammatory reaction like COVID nineteen and line disease. I

533
00:31:25,000 --> 00:31:26,840
Speaker 1: don't know if you have that in your part of

534
00:31:26,880 --> 00:31:29,600
Speaker 1: the world. Okay, these are things we see that are

535
00:31:29,680 --> 00:31:33,160
Speaker 1: quite helpful. And then recovery from stroke and heart attack,

536
00:31:33,640 --> 00:31:37,520
Speaker 1: you know, there's an inflammatory component. And even after traumatic

537
00:31:37,560 --> 00:31:41,280
Speaker 1: brain injury, we're seeing some benefits now using the exosomes.

538
00:31:41,440 --> 00:31:45,120
Speaker 2: Wow, So the exosomes go into the IV.

539
00:31:45,760 --> 00:31:47,920
Speaker 1: They can do IB and the other way to give

540
00:31:47,960 --> 00:31:49,760
Speaker 1: them into the brain. Is nasal spray.

541
00:31:50,040 --> 00:31:53,880
Speaker 2: Oh yeah, there's some really interesting stuff coming out on

542
00:31:54,040 --> 00:31:56,200
Speaker 2: nasl spray. Somebody was talking me the other day about

543
00:31:56,320 --> 00:32:01,239
Speaker 2: BDNF in the nasole spray. I'm like, what, because that

544
00:32:01,360 --> 00:32:03,360
Speaker 2: is direct access to the brion, isn't it.

545
00:32:03,360 --> 00:32:05,400
Speaker 1: It is? There are a couple of different ways to

546
00:32:05,880 --> 00:32:07,840
Speaker 1: you know, get to the brain through the back of

547
00:32:07,880 --> 00:32:10,320
Speaker 1: the nose. There's a ganglion in the back of the nose,

548
00:32:10,360 --> 00:32:14,880
Speaker 1: but the cribber form plate, which is where you know

549
00:32:15,160 --> 00:32:19,080
Speaker 1: there's nerves that transmit smell sneak up into the skull

550
00:32:19,200 --> 00:32:21,680
Speaker 1: and get to that part of the brain. We're using

551
00:32:21,680 --> 00:32:23,600
Speaker 1: that little railway, if you will.

552
00:32:24,240 --> 00:32:28,840
Speaker 2: That is an absolute game changer, right. I was a

553
00:32:28,840 --> 00:32:31,040
Speaker 2: little bit aware of stem cells. There's there's so much

554
00:32:31,080 --> 00:32:33,600
Speaker 2: regulation here in Australia, like trying to get stem cells

555
00:32:33,640 --> 00:32:36,960
Speaker 2: orotpy in Australia. That this is why Australians go to

556
00:32:37,560 --> 00:32:40,560
Speaker 2: whether they go to Mexico, Panama or the United States,

557
00:32:40,600 --> 00:32:43,840
Speaker 2: if they want something that's a little bit less controversial

558
00:32:43,880 --> 00:32:50,360
Speaker 2: and more regulated, but that that delivery through ivy of exosomes.

559
00:32:51,120 --> 00:32:54,600
Speaker 2: That is a potential game changer for so much stuff

560
00:32:54,640 --> 00:32:57,800
Speaker 2: because as you rightly say. If you look at most

561
00:32:57,880 --> 00:33:02,600
Speaker 2: chronic diseases have an inflammatory component, and it is one

562
00:33:02,640 --> 00:33:05,800
Speaker 2: of the major ways that we use is that cellular inflammation.

563
00:33:06,440 --> 00:33:10,560
Speaker 2: So you can actually target certain types of information or

564
00:33:10,600 --> 00:33:14,480
Speaker 2: inflammation in certain areas. Or does it just when you'd

565
00:33:14,520 --> 00:33:17,440
Speaker 2: introduce the exosomes through an IV does it just have

566
00:33:17,720 --> 00:33:20,560
Speaker 2: wide spread effects throughout the whole system. Give me a

567
00:33:20,640 --> 00:33:21,960
Speaker 2: little bit of a steer on it.

568
00:33:22,040 --> 00:33:25,400
Speaker 1: Yeah, So stem cells tend to target areas of inflammation.

569
00:33:25,520 --> 00:33:29,239
Speaker 1: Exosomes are not so smart they go everywhere. They just

570
00:33:29,440 --> 00:33:32,320
Speaker 1: go to the wherever. But because they are so small,

571
00:33:32,480 --> 00:33:35,200
Speaker 1: not that cells aren't small, that these are. You know,

572
00:33:35,360 --> 00:33:39,360
Speaker 1: they're called nanoparticles because they're measured in diameter by nanometers,

573
00:33:39,840 --> 00:33:42,320
Speaker 1: so there are a thousand times smaller than a cell,

574
00:33:42,640 --> 00:33:46,160
Speaker 1: which is measured in microns. So these particles just they

575
00:33:46,240 --> 00:33:48,840
Speaker 1: diffuse as if they're part of the fluid. The problem

576
00:33:48,840 --> 00:33:52,160
Speaker 1: with stem cells IV is such a large percentage of

577
00:33:52,200 --> 00:33:55,240
Speaker 1: that does first goes up the vein to the heart,

578
00:33:55,600 --> 00:33:58,320
Speaker 1: then to the lungs, then back to the heart to

579
00:33:58,320 --> 00:34:00,920
Speaker 1: get pumped to the body. Turns out those cells are

580
00:34:00,960 --> 00:34:05,920
Speaker 1: sticky and the heart lung heart shuttle can take eighty

581
00:34:05,920 --> 00:34:08,480
Speaker 1: percent or more of those cells and the body is

582
00:34:08,719 --> 00:34:12,680
Speaker 1: doesn't get the type of volume of those cells that

583
00:34:12,719 --> 00:34:13,360
Speaker 1: we desire.

584
00:34:14,080 --> 00:34:18,560
Speaker 2: That's interesting, okay. And the exosomes that they behave differently

585
00:34:18,680 --> 00:34:19,880
Speaker 2: are are they.

586
00:34:20,080 --> 00:34:22,280
Speaker 1: They're just they're part of the fluid of the plasma

587
00:34:22,320 --> 00:34:24,680
Speaker 1: of the blood and they just they're not sticky. They

588
00:34:24,760 --> 00:34:27,560
Speaker 1: just go wherever and they don't get hung up because

589
00:34:27,600 --> 00:34:30,560
Speaker 1: of their size and stickiness. Stickiness could be the receptors

590
00:34:30,600 --> 00:34:34,120
Speaker 1: and things. Exosomes have minimal, if any receptors on them.

591
00:34:34,280 --> 00:34:39,200
Speaker 2: Wow, that is fascinating. And are there any known negative

592
00:34:39,200 --> 00:34:42,880
Speaker 2: effects of exisomes going throughout the entire body?

593
00:34:43,440 --> 00:34:46,600
Speaker 1: So the only issues you have besides you know pain

594
00:34:46,680 --> 00:34:48,880
Speaker 1: at the IV side or you know, bleeding from the

595
00:34:48,880 --> 00:34:52,960
Speaker 1: IV site is if you harbor a lot of inflammation already,

596
00:34:52,960 --> 00:34:57,840
Speaker 1: whether it's limes disease or something. Your cells store produce

597
00:34:57,880 --> 00:35:03,279
Speaker 1: and store cells signaling proteins called cytokinds that call for

598
00:35:03,360 --> 00:35:06,960
Speaker 1: the immune system. This is the whole cytokind storm during COVID, right,

599
00:35:07,280 --> 00:35:09,880
Speaker 1: and your body has to get rid of those. So

600
00:35:09,920 --> 00:35:13,320
Speaker 1: when you get the stem cell derived exosomes, those cells

601
00:35:13,360 --> 00:35:16,879
Speaker 1: have to flip over their factory machinery from defense mode

602
00:35:16,920 --> 00:35:21,600
Speaker 1: to peace time, from inflammation to anti inflammation. When they

603
00:35:21,600 --> 00:35:23,759
Speaker 1: do that, they still have to purge out that old

604
00:35:24,200 --> 00:35:26,440
Speaker 1: the stock on the shelves, if you will. And so

605
00:35:26,800 --> 00:35:29,960
Speaker 1: some people as they release those, have a day or

606
00:35:30,040 --> 00:35:33,200
Speaker 1: two of a flu like set of symptoms, not the

607
00:35:33,239 --> 00:35:36,040
Speaker 1: flu itself, but flu like syndrome. Of you have a

608
00:35:36,040 --> 00:35:38,320
Speaker 1: low grade fever. You can have aches and pains, you

609
00:35:38,360 --> 00:35:40,880
Speaker 1: can be sleepy and sluggish because those going into your

610
00:35:40,880 --> 00:35:42,759
Speaker 1: bloodstream and they have to go out your body. So

611
00:35:43,000 --> 00:35:46,160
Speaker 1: as you're flipping over, turning over a new leaf, if

612
00:35:46,200 --> 00:35:49,000
Speaker 1: you will. In the minority of patients, we do see.

613
00:35:48,760 --> 00:35:53,320
Speaker 2: That with IV okay, but no big long term issues. Now.

614
00:35:53,520 --> 00:35:57,640
Speaker 2: That then opens the door in my mind and tell

615
00:35:57,640 --> 00:36:01,120
Speaker 2: me if I'm wrong. From somebody coming in and going

616
00:36:01,640 --> 00:36:06,120
Speaker 2: I have a particular inflammatory issue, to someone coming in

617
00:36:06,160 --> 00:36:08,759
Speaker 2: and going, hey, I'm in my fifties, I feel good,

618
00:36:08,880 --> 00:36:10,560
Speaker 2: but I want to go from good to great.

619
00:36:10,880 --> 00:36:14,600
Speaker 1: Yes. So we have the biohacking crowd.

620
00:36:14,680 --> 00:36:16,040
Speaker 2: I'm one of them. I do them.

621
00:36:16,480 --> 00:36:19,120
Speaker 1: I do IV exosomes on myself four times a year,

622
00:36:19,239 --> 00:36:23,240
Speaker 1: just because you know, preventative. We have some even younger people,

623
00:36:23,280 --> 00:36:26,840
Speaker 1: some people in their upper twenties who want to stay

624
00:36:26,880 --> 00:36:30,040
Speaker 1: young because the earlier you start, the better, and they

625
00:36:30,040 --> 00:36:32,440
Speaker 1: don't always feel a difference. People with a lot of

626
00:36:32,440 --> 00:36:35,279
Speaker 1: information will tend to feel a difference. More energy you need,

627
00:36:35,360 --> 00:36:39,880
Speaker 1: more cognitive you know, sharpness recovery after workouts has improved.

628
00:36:40,040 --> 00:36:42,359
Speaker 1: But the young people will say, I don't really feel much.

629
00:36:42,400 --> 00:36:44,719
Speaker 1: But I had one young athlete who tracks his heart

630
00:36:44,760 --> 00:36:49,120
Speaker 1: rate variability HRV. I can't remember what device he was using,

631
00:36:49,160 --> 00:36:51,200
Speaker 1: maybe a whoop band or something, or or a ring.

632
00:36:51,719 --> 00:36:53,239
Speaker 1: He said, I don't really feel much. But the next

633
00:36:53,280 --> 00:36:57,000
Speaker 1: day he sent me a snapshot of his HRV which

634
00:36:57,040 --> 00:37:00,880
Speaker 1: had jumped without any other intervention by fifty which is,

635
00:37:00,920 --> 00:37:03,880
Speaker 1: as you probably know, huge, right. So we've seen that

636
00:37:03,960 --> 00:37:07,719
Speaker 1: in multiple people as an observation, so we know there

637
00:37:07,800 --> 00:37:12,440
Speaker 1: is a physiologic benefit to the stem cell derived exystems

638
00:37:12,480 --> 00:37:13,600
Speaker 1: even if you don't feel it.

639
00:37:14,000 --> 00:37:16,120
Speaker 4: Yeah, yeah, yeah, And then this is the thing, right,

640
00:37:16,160 --> 00:37:19,600
Speaker 4: if people don't feel that people there are people walking

641
00:37:19,640 --> 00:37:24,040
Speaker 4: around with chronic disease who are not aware of it.

642
00:37:24,160 --> 00:37:30,560
Speaker 2: Like it's not like chronic disease just happens overnight. The processes,

643
00:37:30,680 --> 00:37:36,120
Speaker 2: the cellular mechanisms are there for decades right before people

644
00:37:36,239 --> 00:37:40,799
Speaker 2: feel any type of symptoms. So that's really interesting. So

645
00:37:41,400 --> 00:37:45,000
Speaker 2: for the skeptics in this area, there are there's quite

646
00:37:45,000 --> 00:37:48,680
Speaker 2: a few skeptics, right, there's the believers and the non believers.

647
00:37:49,480 --> 00:37:51,759
Speaker 2: And what's your message to these skeptics.

648
00:37:52,000 --> 00:37:55,000
Speaker 1: Yeah, you'll you'll be surrounded on your deathbed by the

649
00:37:55,080 --> 00:37:59,880
Speaker 1: non skeptics. So it's it'll play out on its own.

650
00:38:00,120 --> 00:38:05,040
Speaker 1: So you know, listen, you know, we try to post

651
00:38:05,040 --> 00:38:08,760
Speaker 1: our success stories, uh, you know, on our social media,

652
00:38:08,840 --> 00:38:11,400
Speaker 1: so people we interview patients, you know, tell us what

653
00:38:11,480 --> 00:38:14,000
Speaker 1: you feel, what you've gotten out of this. That doesn't

654
00:38:14,000 --> 00:38:18,200
Speaker 1: mean everyone gets that result, but you know, hippocratic oath says,

655
00:38:18,280 --> 00:38:21,160
Speaker 1: we have to try to help people with our knowledge, right,

656
00:38:21,200 --> 00:38:24,920
Speaker 1: And I don't want to let, you know, government over

657
00:38:25,040 --> 00:38:30,800
Speaker 1: regulation or naysayers, you know, detract from my fulfilling my oath.

658
00:38:31,160 --> 00:38:34,239
Speaker 1: So this is just an in advancement on what I

659
00:38:34,280 --> 00:38:36,400
Speaker 1: can do for people who are interested. It's an option.

660
00:38:36,440 --> 00:38:38,680
Speaker 1: It's not the only option. No one's going to twist

661
00:38:38,680 --> 00:38:41,680
Speaker 1: your arm to do it. If you're skeptical, do your homework.

662
00:38:42,160 --> 00:38:46,920
Speaker 1: Search all the clinical publications in medical journals on a

663
00:38:46,920 --> 00:38:49,200
Speaker 1: certain topic and see what's out there. Look at the

664
00:38:49,200 --> 00:38:52,120
Speaker 1: biology of it. Just because it's not being done everywhere

665
00:38:52,200 --> 00:38:56,160
Speaker 1: doesn't mean it's wrong. Think about when someone said, hey,

666
00:38:56,160 --> 00:38:59,840
Speaker 1: we've got this mold, it's going to help cure bacterial infection.

667
00:39:00,600 --> 00:39:03,080
Speaker 1: People probably thought penicillin was a little wacky at the

668
00:39:03,120 --> 00:39:03,719
Speaker 1: beginning too.

669
00:39:03,840 --> 00:39:07,799
Speaker 2: So yes, yeah, but that is the best answer I've

670
00:39:07,800 --> 00:39:11,840
Speaker 2: ever heard. You're going to be Surroundedn't your fight nonst

671
00:39:12,000 --> 00:39:18,160
Speaker 2: rafts cracky? So let's talk about the with this regenerate

672
00:39:18,239 --> 00:39:21,839
Speaker 2: medsine and particularly what you're doing the interaction with lifestyle,

673
00:39:22,000 --> 00:39:26,760
Speaker 2: because you could see the potential for some people to go, oh,

674
00:39:26,800 --> 00:39:29,319
Speaker 2: you know what, I don't need to worry about exercise

675
00:39:29,360 --> 00:39:31,920
Speaker 2: and healthy eating. I'll just go and get my stem

676
00:39:31,960 --> 00:39:34,719
Speaker 2: cells are exosomes done on an ivy every couple of months,

677
00:39:34,719 --> 00:39:35,520
Speaker 2: and then it'll be good.

678
00:39:35,960 --> 00:39:38,239
Speaker 1: Yeah, listen, it's it's the whole package. Right. If you

679
00:39:38,719 --> 00:39:42,680
Speaker 1: might have a small benefit from a regenerative medicine approach,

680
00:39:42,920 --> 00:39:45,399
Speaker 1: but if you're not living clean and your your cells

681
00:39:45,440 --> 00:39:47,320
Speaker 1: are going to flip right back to their bad biology

682
00:39:47,320 --> 00:39:49,480
Speaker 1: in a minute. So you know, we we like to

683
00:39:49,520 --> 00:39:54,600
Speaker 1: optimize people ahead of time, diet, sleep, exercise strategies, supplements,

684
00:39:55,280 --> 00:39:59,080
Speaker 1: Hormone optimization in some cases or misis all of the above.

685
00:39:59,560 --> 00:40:02,399
Speaker 1: The better your body is receptive to these, the more

686
00:40:02,440 --> 00:40:03,920
Speaker 1: you'll get out of it, and the more and the

687
00:40:03,960 --> 00:40:05,160
Speaker 1: more prolonged response.

688
00:40:05,520 --> 00:40:10,719
Speaker 2: Theoretically, and in terms of the length of the benefits,

689
00:40:11,160 --> 00:40:17,000
Speaker 2: presumably that depends on the state of the individual that's

690
00:40:17,120 --> 00:40:18,799
Speaker 2: coming in. I'm guessing, but.

691
00:40:18,920 --> 00:40:21,480
Speaker 1: It's just like a degenerated joint. If we see, you know,

692
00:40:21,760 --> 00:40:25,040
Speaker 1: of an end stage worn down joint, what we call

693
00:40:25,160 --> 00:40:28,600
Speaker 1: bone on bone, generally speaking, it's gonna take a lot

694
00:40:28,640 --> 00:40:32,439
Speaker 1: more to help that person get the regenerative benefits they're

695
00:40:32,440 --> 00:40:35,560
Speaker 1: looking for. If someone is only partially degenerated and starting

696
00:40:35,600 --> 00:40:38,520
Speaker 1: to have symptoms on the earlier side, then there's a

697
00:40:38,520 --> 00:40:40,759
Speaker 1: lot less travel that has to be done to get

698
00:40:40,760 --> 00:40:42,920
Speaker 1: that joint to improve. So we like to get to

699
00:40:42,960 --> 00:40:46,560
Speaker 1: things earlier. Although I wouldn't turn away someone bone on bone,

700
00:40:47,040 --> 00:40:49,520
Speaker 1: because if I can help someone avoid a knee replacement

701
00:40:49,600 --> 00:40:53,799
Speaker 1: or hip replacement or shoulder replacement or something, I think

702
00:40:53,800 --> 00:40:55,640
Speaker 1: that I think that's a good service.

703
00:40:56,160 --> 00:40:59,200
Speaker 2: Now, interesting question here, because I was, just as you

704
00:40:59,239 --> 00:41:02,760
Speaker 2: were talking about it, thinking about some of the recent

705
00:41:02,800 --> 00:41:07,160
Speaker 2: research you may be aware of that said that humans

706
00:41:07,160 --> 00:41:11,800
Speaker 2: seem to age it's not linear. There was that paper

707
00:41:11,840 --> 00:41:14,759
Speaker 2: that was released saying that there seemed to be a

708
00:41:14,880 --> 00:41:19,160
Speaker 2: couple of aging spurts, one in the early forties, one

709
00:41:19,239 --> 00:41:22,280
Speaker 2: around sixty, and then there was another paper I find

710
00:41:22,840 --> 00:41:25,400
Speaker 2: that there was seem to be a third one around

711
00:41:25,480 --> 00:41:29,400
Speaker 2: seventy eight or eighty. That first study didn't follow people

712
00:41:29,440 --> 00:41:33,160
Speaker 2: to that age, So there's this suggestion now that aging

713
00:41:33,239 --> 00:41:35,600
Speaker 2: is not linear. I think that study needs to be

714
00:41:35,640 --> 00:41:39,160
Speaker 2: repeated because the sample size was relatively small. Right, there's

715
00:41:39,200 --> 00:41:43,040
Speaker 2: all these headlines around it. But if true and it

716
00:41:43,080 --> 00:41:47,200
Speaker 2: seems to be certainly within that population, does that then

717
00:41:47,760 --> 00:41:51,560
Speaker 2: suggest that there would be optimal times of your life

718
00:41:51,800 --> 00:41:57,320
Speaker 2: forgetting this, or if you were talking to your younger self,

719
00:41:58,200 --> 00:42:02,040
Speaker 2: would you be saying, hey, to just start this really early?

720
00:42:02,200 --> 00:42:05,160
Speaker 2: Like what? So, I guess what I'm asking, when do

721
00:42:05,320 --> 00:42:09,680
Speaker 2: you start to see those signs of significant cellular wir

722
00:42:09,880 --> 00:42:14,440
Speaker 2: in te where this sort of interventions would be the

723
00:42:14,520 --> 00:42:17,279
Speaker 2: best buying for your buck in terms of the marie

724
00:42:17,320 --> 00:42:17,560
Speaker 2: you're going.

725
00:42:17,760 --> 00:42:20,400
Speaker 1: It's a great question. It's a it's a thought question.

726
00:42:20,560 --> 00:42:23,600
Speaker 1: So I think what we need to know is more

727
00:42:23,680 --> 00:42:28,320
Speaker 1: about why we have these we'll call it steep falloffs

728
00:42:28,600 --> 00:42:31,719
Speaker 1: in you know, cellular activity in the forties and in

729
00:42:31,760 --> 00:42:36,240
Speaker 1: the sixties, because nothing in biology is truly linear anyway. Yes,

730
00:42:36,280 --> 00:42:40,240
Speaker 1: and so is it because you know we we deplete

731
00:42:40,640 --> 00:42:44,680
Speaker 1: you know, stem cell activity. Is it because of hormonal

732
00:42:44,800 --> 00:42:47,680
Speaker 1: changes or is it the perfect storm of more than

733
00:42:47,680 --> 00:42:50,759
Speaker 1: one of these things? And in biology it always is, right,

734
00:42:50,800 --> 00:42:54,200
Speaker 1: it's a it's a combination of competing factors. So if

735
00:42:54,239 --> 00:42:59,120
Speaker 1: we could, if we could start regenerative medicine before that first,

736
00:42:59,160 --> 00:43:02,000
Speaker 1: and before that's can peak, can we push that peak

737
00:43:02,040 --> 00:43:06,960
Speaker 1: off in time? I think that is really the strategy here.

738
00:43:07,360 --> 00:43:09,919
Speaker 1: That doesn't mean in the middle of one of those

739
00:43:10,320 --> 00:43:14,440
Speaker 1: big cliffs of the aging process we couldn't help someone

740
00:43:14,480 --> 00:43:18,400
Speaker 1: slow or you know, lessen the height of the cliff

741
00:43:18,920 --> 00:43:22,600
Speaker 1: on the curve either. But I think you have to

742
00:43:22,640 --> 00:43:25,600
Speaker 1: start early and often and get ahead of it in

743
00:43:25,640 --> 00:43:29,600
Speaker 1: a preventative manner, which is really what good medicine is

744
00:43:29,640 --> 00:43:32,360
Speaker 1: all about. Is promoting health and wellness and preventing illness

745
00:43:32,440 --> 00:43:35,239
Speaker 1: not having to treat it is the big win.

746
00:43:35,719 --> 00:43:39,160
Speaker 2: Wow, now you are taught. That's very controversial, Jeff. You're

747
00:43:39,200 --> 00:43:41,799
Speaker 2: talking about a healthcare system rather than a sick car

748
00:43:41,840 --> 00:43:46,279
Speaker 2: system there, because in this Cardana, I'm pretty sure it's

749
00:43:46,560 --> 00:43:51,239
Speaker 2: very similar in the States. In this country, ninety seven

750
00:43:51,360 --> 00:43:55,120
Speaker 2: or ninety eight percent of all government healthcare spending is

751
00:43:55,160 --> 00:44:00,000
Speaker 2: on tertiary treatment, and there's very very little on primary

752
00:44:00,080 --> 00:44:03,279
Speaker 2: and secondary prevention. I often say, we don't have a

753
00:44:03,280 --> 00:44:05,840
Speaker 2: health care system in this country. We have a sick

754
00:44:06,000 --> 00:44:07,520
Speaker 2: cur system in this country.

755
00:44:07,600 --> 00:44:10,439
Speaker 1: Yes, same here. You know, it's even if they spent

756
00:44:10,560 --> 00:44:14,440
Speaker 1: more money here in the US on preventative care, they

757
00:44:14,719 --> 00:44:19,280
Speaker 1: would also in parallel have to remove all the nasty

758
00:44:19,320 --> 00:44:22,920
Speaker 1: inclusions in our food source and water and EMPs and

759
00:44:22,960 --> 00:44:24,800
Speaker 1: all kinds of things going on. So it's going to

760
00:44:24,840 --> 00:44:27,359
Speaker 1: take more than just preventive healthcare. It's going to take

761
00:44:27,400 --> 00:44:30,920
Speaker 1: preventative behaviors for our entire population.

762
00:44:31,560 --> 00:44:36,759
Speaker 2: Yeah, yeah, absolutely so, given that the amazing advances and

763
00:44:36,920 --> 00:44:41,440
Speaker 2: technology that are happening right now, you know, going even

764
00:44:41,520 --> 00:44:43,880
Speaker 2: in this field, going from stand cells to the end

765
00:44:43,880 --> 00:44:48,799
Speaker 2: harnessing x zones, what do you think the future trajectory

766
00:44:49,040 --> 00:44:53,759
Speaker 2: is for this longevity regenerative medicine, call it whatever you want.

767
00:44:54,000 --> 00:44:55,920
Speaker 2: I like to call it. I like to focus on

768
00:44:55,960 --> 00:45:00,239
Speaker 2: the health span rather than the lifespan. But given that

769
00:45:00,320 --> 00:45:03,880
Speaker 2: your finger is well and truly on the pulse here,

770
00:45:04,360 --> 00:45:06,200
Speaker 2: what do you think future stey it looks like.

771
00:45:06,200 --> 00:45:09,160
Speaker 1: Well, I think the future is already here in some places,

772
00:45:09,239 --> 00:45:11,799
Speaker 1: just not here in the US. But we're working on

773
00:45:11,920 --> 00:45:14,080
Speaker 1: some projects here in my own clinic to get what

774
00:45:14,160 --> 00:45:16,840
Speaker 1: we call designer exosomes. These are exisomes that would be

775
00:45:16,920 --> 00:45:21,440
Speaker 1: chalk full of mitochondria, for example, to donate donate those

776
00:45:21,480 --> 00:45:25,359
Speaker 1: mitochondria to cells whose mitochondria are less functional, not only

777
00:45:25,360 --> 00:45:29,360
Speaker 1: for mitochondria disease, but for frailty and to help improve

778
00:45:29,480 --> 00:45:32,600
Speaker 1: muscle mass. As you know, muscle mass and boneens are

779
00:45:32,600 --> 00:45:36,200
Speaker 1: correlated with longevity and also brain function. The brain is

780
00:45:36,280 --> 00:45:39,960
Speaker 1: highly dependent on mitochondria, and I think we need to

781
00:45:40,000 --> 00:45:43,239
Speaker 1: spend more time giving mitochondria our love, and if we

782
00:45:43,280 --> 00:45:45,560
Speaker 1: take care of mitochondria, we are taking care of ourselves.

783
00:45:45,640 --> 00:45:48,600
Speaker 1: So those will be designer exosomes. The other one we're

784
00:45:48,640 --> 00:45:51,200
Speaker 1: working closely with now and hope to have very soon

785
00:45:51,320 --> 00:45:56,000
Speaker 1: are a certain subpopulation of exosomes come from immune cells.

786
00:45:56,520 --> 00:45:59,720
Speaker 1: And these immune cells, these specific T cells, their job

787
00:45:59,880 --> 00:46:04,280
Speaker 1: is to identify and remove by cell death certain abnormal

788
00:46:04,320 --> 00:46:07,640
Speaker 1: cells like cancer cells. So you can imagine we have

789
00:46:07,680 --> 00:46:14,640
Speaker 1: these targeted exosomes that can help help someone address a

790
00:46:14,800 --> 00:46:19,279
Speaker 1: cancer diagnosis and whether it's a solid tumor or a

791
00:46:19,320 --> 00:46:22,520
Speaker 1: circulating tumor. And these are in addition to you know,

792
00:46:22,600 --> 00:46:25,080
Speaker 1: some of the things that are becoming online here now

793
00:46:25,680 --> 00:46:29,640
Speaker 1: these called car T cells where they train kind of

794
00:46:29,680 --> 00:46:34,600
Speaker 1: these these regenerative cells through a process to identify and

795
00:46:34,640 --> 00:46:37,640
Speaker 1: remove cancer cells. It's almost like your own vaccinated cells

796
00:46:37,800 --> 00:46:40,880
Speaker 1: come in and do the job. That's another angle. And

797
00:46:40,960 --> 00:46:44,800
Speaker 1: then as I mentioned earlier, these induced pluropotent more embryonic

798
00:46:44,920 --> 00:46:49,360
Speaker 1: cells that as you probably saw in the news in

799
00:46:49,400 --> 00:46:52,600
Speaker 1: the last few months in China, they cured a person

800
00:46:52,640 --> 00:46:55,319
Speaker 1: of diabetes type one. They did it by using some

801
00:46:55,360 --> 00:46:59,080
Speaker 1: of these induced pluropotent cells. So those cells have more

802
00:46:59,120 --> 00:47:02,360
Speaker 1: ability to do. We just need to control them safely.

803
00:47:02,760 --> 00:47:05,160
Speaker 1: That's some of the limitations on those right now.

804
00:47:05,640 --> 00:47:09,839
Speaker 2: That's really interesting, and I think obviously the brain has

805
00:47:09,920 --> 00:47:13,640
Speaker 2: then got to be a target because as we what

806
00:47:13,719 --> 00:47:17,280
Speaker 2: we see in Australia and I would imagine it's very similar,

807
00:47:17,320 --> 00:47:22,160
Speaker 2: there is the massive rise in dementia as a killer.

808
00:47:22,680 --> 00:47:24,719
Speaker 2: And I think there's a couple of things that are

809
00:47:24,760 --> 00:47:30,480
Speaker 2: behind that. Right is number one, unhealthy behaviors that people have.

810
00:47:31,080 --> 00:47:35,960
Speaker 2: But secondly, as we live longer, right as the population

811
00:47:36,160 --> 00:47:42,240
Speaker 2: is living longer, neurodegenertive diseases and cancers almost become something

812
00:47:42,280 --> 00:47:45,160
Speaker 2: that's going to be locked in, right because of just

813
00:47:45,320 --> 00:47:47,360
Speaker 2: that overall we're.

814
00:47:47,200 --> 00:47:51,840
Speaker 1: In terror of the body, right, agreed. Listen, the older

815
00:47:51,880 --> 00:47:55,080
Speaker 1: we live, the more degenerative problems we are for facing.

816
00:47:55,440 --> 00:47:58,560
Speaker 1: So the earlier we can start some type of regenerative

817
00:47:58,600 --> 00:48:03,520
Speaker 1: behaviors in our lifestyle and our food and maybe even

818
00:48:03,640 --> 00:48:07,839
Speaker 1: augmentative regeneritive therapists like we're talking about today, to help

819
00:48:07,880 --> 00:48:12,279
Speaker 1: slow that process, that would be a game changer. It

820
00:48:12,400 --> 00:48:14,440
Speaker 1: might push the problem down the line. And I think

821
00:48:14,440 --> 00:48:16,960
Speaker 1: you could do to delay the formation of the generative

822
00:48:16,960 --> 00:48:20,840
Speaker 1: diseases gives us a chance to learn about them more

823
00:48:21,320 --> 00:48:23,680
Speaker 1: and have a new solution for them ten or twenty

824
00:48:23,719 --> 00:48:24,279
Speaker 1: years from now.

825
00:48:24,680 --> 00:48:29,040
Speaker 2: What's your thoughts? So a little bit off pace this question, right,

826
00:48:29,080 --> 00:48:33,719
Speaker 2: So in the whole longevity medicine space, there are some

827
00:48:33,920 --> 00:48:38,680
Speaker 2: people who are really focused on enhancing health span, and

828
00:48:38,719 --> 00:48:41,759
Speaker 2: then there's the other crowd that are focused on enhancing

829
00:48:41,920 --> 00:48:47,560
Speaker 2: lifespan and who believe that it's possible and that we're

830
00:48:47,560 --> 00:48:50,680
Speaker 2: going to see human beings live to one hundred and

831
00:48:50,680 --> 00:48:54,080
Speaker 2: fifty two hundred years old. You have some people talking

832
00:48:54,120 --> 00:48:58,440
Speaker 2: about that. What's your view on this? Opinion. Right, this

833
00:48:58,560 --> 00:49:00,000
Speaker 2: is obviously a hypothetical question.

834
00:49:00,520 --> 00:49:04,040
Speaker 1: Yep, Well, listen, if you all your time and efforts

835
00:49:04,080 --> 00:49:08,440
Speaker 1: full time, we're dedicated to living longer, those things that

836
00:49:08,480 --> 00:49:10,759
Speaker 1: make you live longer will also make you healthier. So

837
00:49:11,080 --> 00:49:14,280
Speaker 1: you're working towards life span, is really also working towards

838
00:49:14,320 --> 00:49:16,680
Speaker 1: health span. But you're right, we don't want to just

839
00:49:16,760 --> 00:49:19,319
Speaker 1: live longer and be laid up in a nursing home

840
00:49:19,360 --> 00:49:21,719
Speaker 1: for decades at the end of our life, right. We

841
00:49:21,760 --> 00:49:24,040
Speaker 1: want our we want our health span to fill our

842
00:49:24,080 --> 00:49:28,160
Speaker 1: lifespan with really, so they end at the same time. So,

843
00:49:28,440 --> 00:49:30,200
Speaker 1: you know, if you had to like a Brian Johnson,

844
00:49:30,280 --> 00:49:32,879
Speaker 1: his full time endo it you know, he he does

845
00:49:33,040 --> 00:49:36,439
Speaker 1: have a propensity to live beyond one fifty and so forth.

846
00:49:36,480 --> 00:49:40,279
Speaker 1: He's doing everything perfectly right, He's Yeah, he's basically like

847
00:49:40,320 --> 00:49:43,800
Speaker 1: a pristine you know car that never leaves the garage

848
00:49:43,920 --> 00:49:46,200
Speaker 1: or gets an oil change every day whether it needs

849
00:49:46,200 --> 00:49:49,200
Speaker 1: it or not. You know, so it's going to last longer,

850
00:49:49,320 --> 00:49:52,400
Speaker 1: it's going to you know, people talk about escape velocity

851
00:49:52,440 --> 00:49:54,960
Speaker 1: where we're going to live forever.

852
00:49:56,040 --> 00:49:59,280
Speaker 2: Talks about escape velocity, Right, I don't.

853
00:49:59,080 --> 00:50:01,560
Speaker 1: Know what that's going to teake. I'm not seeking that.

854
00:50:01,760 --> 00:50:04,280
Speaker 1: I don't know that anyone. You know, a few people

855
00:50:04,320 --> 00:50:08,359
Speaker 1: may have that desire at some point. You know, we're

856
00:50:08,719 --> 00:50:11,680
Speaker 1: talking more about you know, the sci fi and things

857
00:50:11,719 --> 00:50:13,239
Speaker 1: like that, but that doesn't mean that you're not going

858
00:50:13,320 --> 00:50:16,720
Speaker 1: to be less fiction in the future. I'm not working

859
00:50:16,760 --> 00:50:19,200
Speaker 1: towards escape velocity. But everything we do to you know,

860
00:50:19,280 --> 00:50:22,880
Speaker 1: push health span and longevity, we will see people we

861
00:50:22,920 --> 00:50:25,080
Speaker 1: already we already have people living into the one hundred

862
00:50:25,080 --> 00:50:27,920
Speaker 1: and twenties. We will see one hundred and fifties in

863
00:50:28,080 --> 00:50:33,200
Speaker 1: subgroups of lifelong good behavioring good behavior people who are

864
00:50:33,239 --> 00:50:34,680
Speaker 1: doing all the right things along the way. And then

865
00:50:34,719 --> 00:50:37,480
Speaker 1: maybe some strategies on top of that with stem cells

866
00:50:37,480 --> 00:50:38,000
Speaker 1: and what have you.

867
00:50:38,239 --> 00:50:41,560
Speaker 2: Yeah. Interesting, So you think that that is quite quite

868
00:50:41,560 --> 00:50:46,120
Speaker 2: a possibility, And right right now I'm interested until that's proven. Right,

869
00:50:46,239 --> 00:50:50,839
Speaker 2: I'm interested in you designing these designer XI zomes that

870
00:50:50,920 --> 00:50:55,359
Speaker 2: will KP me healthy and vital, and then as soon

871
00:50:55,360 --> 00:50:59,920
Speaker 2: as I head one hundred, they all explode and I

872
00:51:00,120 --> 00:51:01,480
Speaker 2: that's it. I'm just done.

873
00:51:01,960 --> 00:51:04,359
Speaker 1: That's it. Yeah, I don't think we're quite know yet

874
00:51:04,400 --> 00:51:05,120
Speaker 1: time living it.

875
00:51:05,239 --> 00:51:08,520
Speaker 2: Yeah, So talk about you know what you guys do

876
00:51:08,719 --> 00:51:13,040
Speaker 2: the resale stuff. Are you making sure that you're right

877
00:51:13,120 --> 00:51:16,520
Speaker 2: on the bleeding edge of all of this stuff.

878
00:51:16,800 --> 00:51:20,640
Speaker 1: Well, a few things. One is we only use the

879
00:51:20,719 --> 00:51:24,880
Speaker 1: highest quality biologics. So the stem cell drived exostomes we

880
00:51:24,960 --> 00:51:28,320
Speaker 1: have come from young, healthy mothers that are screened in

881
00:51:28,360 --> 00:51:33,160
Speaker 1: their first trimester and can't be drinking, can't be smoking,

882
00:51:33,640 --> 00:51:37,480
Speaker 1: they can't be having high risk behaviors. They have to

883
00:51:37,520 --> 00:51:42,480
Speaker 1: be non vaccinated for COVID not because that's necessarily bad,

884
00:51:42,520 --> 00:51:44,360
Speaker 1: it's just we just don't know enough. We haven't had

885
00:51:44,480 --> 00:51:48,359
Speaker 1: enough time to understand the full linkture of that. So

886
00:51:48,760 --> 00:51:52,960
Speaker 1: just to remove that variable, we're using unvaxed donors, and

887
00:51:53,000 --> 00:51:56,400
Speaker 1: then those those tissues go to a highly competent and

888
00:51:56,440 --> 00:51:59,960
Speaker 1: certified lab where they're tested in screen for all diseases.

889
00:52:00,200 --> 00:52:01,879
Speaker 1: So we're only using the best of the best.

890
00:52:02,160 --> 00:52:05,239
Speaker 2: And tell our list is why mother's frite, why females?

891
00:52:05,680 --> 00:52:08,640
Speaker 2: Why to just give our listeners a sense of that.

892
00:52:09,560 --> 00:52:14,720
Speaker 1: Because females have wombs, and those wombs produce the best

893
00:52:14,880 --> 00:52:18,880
Speaker 1: stem cells when it's creating and developing a fetus. So

894
00:52:18,920 --> 00:52:23,160
Speaker 1: we're taking from the amniotic fluid, the growth factors, the proteins,

895
00:52:23,160 --> 00:52:26,840
Speaker 1: the peptides, the exosomes, and we're getting them in a

896
00:52:26,880 --> 00:52:31,000
Speaker 1: concentrated way. That's why I mean, that's what I prefer you.

897
00:52:31,000 --> 00:52:33,160
Speaker 1: You could take stem cells or you could probably even

898
00:52:33,160 --> 00:52:35,680
Speaker 1: derive exisomes from a man, but you have to send

899
00:52:35,719 --> 00:52:40,400
Speaker 1: them off and it's very expensive and doesn't doesn't make twist. Okay,

900
00:52:40,560 --> 00:52:43,800
Speaker 1: we take them from the baby factories basically, yeah, yeah, okay.

901
00:52:44,080 --> 00:52:47,360
Speaker 2: And do you guys use peptides as well as stem

902
00:52:47,360 --> 00:52:48,440
Speaker 2: cells and exosomes.

903
00:52:48,680 --> 00:52:51,480
Speaker 1: Yeah? It just to be clear, most peptides. Our bodies

904
00:52:51,480 --> 00:52:54,799
Speaker 1: make peptides, stem cells derive peptides. Exisomes are chalk full

905
00:52:54,840 --> 00:52:59,600
Speaker 1: of peptides. We also use exogenous peptides, supplemental peptides. Usually

906
00:52:59,600 --> 00:53:02,319
Speaker 1: if you're here something you want, the Wolverine protocol, the

907
00:53:02,360 --> 00:53:05,920
Speaker 1: BPC one fifty seven TB five hundred copper peptid. There

908
00:53:05,920 --> 00:53:08,640
Speaker 1: are so many out there. We are learning more and

909
00:53:08,680 --> 00:53:11,840
Speaker 1: more about them all the time, and.

910
00:53:11,880 --> 00:53:16,000
Speaker 2: The FDA are starting to come down a little bit

911
00:53:16,080 --> 00:53:20,640
Speaker 2: on peptides. Have you any concern about the FDA coming

912
00:53:20,680 --> 00:53:23,040
Speaker 2: down on exisomes in the future.

913
00:53:23,520 --> 00:53:26,240
Speaker 1: Yeah, So the listen anything that the FDA is coming

914
00:53:26,280 --> 00:53:31,240
Speaker 1: down on without a foundational basis, meaning they're disregarding the lurture.

915
00:53:31,840 --> 00:53:33,719
Speaker 1: There's got to be another reason for that, and you

916
00:53:33,800 --> 00:53:36,840
Speaker 1: got to follow all of the influences and the money

917
00:53:36,840 --> 00:53:39,640
Speaker 1: for that. But the FDA says they do regulate these things.

918
00:53:39,680 --> 00:53:44,719
Speaker 1: Doctors do not prescribe peptides. We can coach and recommend

919
00:53:44,719 --> 00:53:46,919
Speaker 1: them and people have to obtain them on their own,

920
00:53:47,040 --> 00:53:51,239
Speaker 1: which is easy. And then for the exisomes, we're very

921
00:53:51,440 --> 00:53:55,680
Speaker 1: very careful that we aren't making any claims marketing claims

922
00:53:55,680 --> 00:53:58,160
Speaker 1: that we're curing or treating something because we want to

923
00:53:58,160 --> 00:54:01,240
Speaker 1: remain compliant with the FDA regulates.

924
00:54:01,640 --> 00:54:06,640
Speaker 2: I can imagine there's a fur bit of frustration in

925
00:54:06,880 --> 00:54:12,320
Speaker 2: your field and people like you around the limitations that

926
00:54:13,160 --> 00:54:16,000
Speaker 2: are placed on you know, what you can access, what

927
00:54:16,040 --> 00:54:17,480
Speaker 2: you can do for your patients.

928
00:54:18,840 --> 00:54:21,680
Speaker 1: Sometimes I think that the patients who are inclined to

929
00:54:21,680 --> 00:54:27,600
Speaker 1: look into these treatments understand that they are newer to

930
00:54:27,640 --> 00:54:30,440
Speaker 1: the US. We share with our patients all the clinical

931
00:54:30,480 --> 00:54:34,040
Speaker 1: literature that they're interested in, usually that's from Asia or

932
00:54:34,280 --> 00:54:38,520
Speaker 1: from Europe. We show them what people are doing. They

933
00:54:38,560 --> 00:54:41,480
Speaker 1: are approved by the way. In the States. There's one

934
00:54:41,520 --> 00:54:45,560
Speaker 1: state that this past may put into effect a law

935
00:54:45,600 --> 00:54:48,000
Speaker 1: that was passed a little bit earlier that does approve

936
00:54:48,080 --> 00:54:51,680
Speaker 1: the use of regenerative biologics, and that's the state of Utah. So,

937
00:54:52,600 --> 00:54:55,040
Speaker 1: like a lot of crazy things in the US, we're

938
00:54:55,120 --> 00:54:58,400
Speaker 1: sort of at civil war right where the federal government

939
00:54:58,800 --> 00:55:02,400
Speaker 1: has one opinion, the individual state or states have others.

940
00:55:03,040 --> 00:55:07,359
Speaker 2: Yeah, that's that's that's really interesting. So give our listeners

941
00:55:07,440 --> 00:55:11,359
Speaker 2: just a little bit of a guidance around those who

942
00:55:11,400 --> 00:55:16,439
Speaker 2: want to explore regenerative treatments. What sort of guidance would

943
00:55:16,480 --> 00:55:19,200
Speaker 2: you give somebody who's thinking about this particularly, You know,

944
00:55:19,239 --> 00:55:22,319
Speaker 2: a large part of my audience is in Australia where

945
00:55:22,640 --> 00:55:26,200
Speaker 2: we can't access clinics like yours, So what sort of

946
00:55:26,280 --> 00:55:29,920
Speaker 2: guidance would you give people in general and who are

947
00:55:30,320 --> 00:55:33,399
Speaker 2: interested in this area, because for me it's a very

948
00:55:33,440 --> 00:55:37,680
Speaker 2: interesting area. But do you know talking about xisomes, that's

949
00:55:37,760 --> 00:55:40,840
Speaker 2: like wow, this is game changing stuff.

950
00:55:41,239 --> 00:55:44,319
Speaker 1: Well, if you're in Australia and you are you want

951
00:55:44,360 --> 00:55:48,560
Speaker 1: to stimulate your own exosomes, you can exercise, do yoga.

952
00:55:49,280 --> 00:55:53,000
Speaker 1: They stimulate stemsar release, which stimulates the exosome activity. You

953
00:55:53,040 --> 00:55:57,320
Speaker 1: can imbibe exosomes there. You can get exosomes from healthy

954
00:55:57,680 --> 00:56:01,160
Speaker 1: fruits and vegetables. Plants you can have them from they're

955
00:56:01,280 --> 00:56:04,239
Speaker 1: very rich in bone marrow or bone broth. They're very

956
00:56:04,360 --> 00:56:08,279
Speaker 1: rich in colosstrum. They're available in milk, well closs from

957
00:56:08,280 --> 00:56:12,320
Speaker 1: its better mother's milk, the first milk. In some cultures

958
00:56:12,320 --> 00:56:15,759
Speaker 1: people actually eat the placenta, so yes, yeah, right, and

959
00:56:15,840 --> 00:56:18,960
Speaker 1: it's placental capsules or things like that make you be

960
00:56:19,040 --> 00:56:22,359
Speaker 1: animal as well, have to be human. So that's one

961
00:56:22,400 --> 00:56:25,680
Speaker 1: way to get some axisomes into your body. And then

962
00:56:25,800 --> 00:56:29,600
Speaker 1: if you're interested in something you know more direct than supplemented,

963
00:56:29,680 --> 00:56:32,880
Speaker 1: like what we do here, do your homework so you know,

964
00:56:33,080 --> 00:56:36,440
Speaker 1: use your your internet searches, search for the kinds of

965
00:56:36,440 --> 00:56:39,600
Speaker 1: things you are looking to address, whether it's anti aging

966
00:56:39,960 --> 00:56:43,920
Speaker 1: or knee degeneration, or you know, lupus or what have you,

967
00:56:44,440 --> 00:56:47,120
Speaker 1: and type in the word stem cells, lupus, what have you.

968
00:56:47,400 --> 00:56:49,759
Speaker 1: If you type in exosomes instead of stem cells, you're

969
00:56:49,800 --> 00:56:52,440
Speaker 1: not going to get as much literature. We do translate

970
00:56:52,480 --> 00:56:56,680
Speaker 1: a lot of a stem cell type of clinical reports

971
00:56:56,680 --> 00:56:59,799
Speaker 1: from years gone by into axisomes, since stem cells are

972
00:56:59,800 --> 00:57:03,400
Speaker 1: really the delivery of exisomes. And then see what's out there,

973
00:57:03,719 --> 00:57:06,040
Speaker 1: and if you find something interesting, see where they're doing it,

974
00:57:06,200 --> 00:57:08,400
Speaker 1: you know, and are you willing to travel? I suppose

975
00:57:08,400 --> 00:57:09,120
Speaker 1: that might be a way.

976
00:57:09,400 --> 00:57:11,920
Speaker 2: I think lots of people will be willing to travel,

977
00:57:12,360 --> 00:57:15,720
Speaker 2: so presumably people from overseas can come to your clinic

978
00:57:15,880 --> 00:57:20,120
Speaker 2: sure and get these exosome I these or our treatments

979
00:57:20,120 --> 00:57:24,440
Speaker 2: for particular stuff. So work this, Jeff. This has been

980
00:57:24,520 --> 00:57:29,840
Speaker 2: absolutely fascinating. Where can people go to learn more about

981
00:57:30,000 --> 00:57:33,600
Speaker 2: what you do specifically and your clinic and the treatments

982
00:57:33,640 --> 00:57:34,520
Speaker 2: that are on offer.

983
00:57:34,800 --> 00:57:38,360
Speaker 1: Thank you, Paul. The practice name is called re Celebrate

984
00:57:38,920 --> 00:57:43,440
Speaker 1: because we're celebrating the renewal of ourselves. So that's brilliant,

985
00:57:46,040 --> 00:57:47,840
Speaker 1: and that's why we walk the dog at night so

986
00:57:47,880 --> 00:57:49,120
Speaker 1: we can come up with these ideas.

987
00:57:49,200 --> 00:57:49,360
Speaker 2: Right.

988
00:57:49,600 --> 00:57:53,439
Speaker 1: It's spelled r e c e l L for sell

989
00:57:54,080 --> 00:57:57,840
Speaker 1: e b r A te And if you type that

990
00:57:57,920 --> 00:58:00,640
Speaker 1: in your search browser, you will find us. I think

991
00:58:00,640 --> 00:58:02,840
Speaker 1: I'm the only person using that word in that spelling.

992
00:58:03,320 --> 00:58:07,120
Speaker 1: Our clinic name. That's that's our website, that's our Instagram,

993
00:58:07,240 --> 00:58:09,960
Speaker 1: that's our Facebook, that's our LinkedIn, that's our whatever. We

994
00:58:10,040 --> 00:58:12,520
Speaker 1: have a YouTube. Just type that in you'll find it.

995
00:58:13,160 --> 00:58:15,680
Speaker 2: Ya'll tell you what the day that when you were

996
00:58:15,680 --> 00:58:17,880
Speaker 2: walking the dog and you came up with that. I'm

997
00:58:17,880 --> 00:58:20,800
Speaker 2: sure you come home and jumped on to see if

998
00:58:20,840 --> 00:58:24,200
Speaker 2: that demand name was taken that ought to be in

999
00:58:24,240 --> 00:58:24,520
Speaker 2: the day.

1000
00:58:24,760 --> 00:58:29,000
Speaker 1: You're just like, yes, yes, that's exactly what happened. I

1001
00:58:29,040 --> 00:58:31,440
Speaker 1: probably bought it, you know, on the walk, you know,

1002
00:58:31,560 --> 00:58:34,040
Speaker 1: got into my account, checked it out. It's available, go

1003
00:58:34,240 --> 00:58:37,080
Speaker 1: you know by right then and there. So you're exactly right.

1004
00:58:38,240 --> 00:58:41,880
Speaker 2: That is brilliant, Je. Look, this must be for you

1005
00:58:42,480 --> 00:58:45,920
Speaker 2: particularly exciting, right, and a new lease of life for

1006
00:58:46,040 --> 00:58:51,240
Speaker 2: your career, right, so you're re celebrating your career very

1007
00:58:51,280 --> 00:58:53,960
Speaker 2: good as well as do all of this stuff. So

1008
00:58:54,400 --> 00:58:56,680
Speaker 2: it must be must be so cold to be on

1009
00:58:56,720 --> 00:59:00,600
Speaker 2: the bleeding edge, but also to just be able to

1010
00:59:01,080 --> 00:59:06,360
Speaker 2: intervene with people in a pretty non indasive way compared

1011
00:59:06,400 --> 00:59:10,600
Speaker 2: to some of the other traditional treatments and just see

1012
00:59:11,000 --> 00:59:14,880
Speaker 2: people walking out of your office in completely different health

1013
00:59:14,920 --> 00:59:16,600
Speaker 2: than they walked in. That's going to be cool.

1014
00:59:16,680 --> 00:59:20,280
Speaker 1: It's wonderfully rewarding, and you're you're absolutely right. I have

1015
00:59:20,360 --> 00:59:24,520
Speaker 1: a shot of regenerative activity into my own professional life.

1016
00:59:24,600 --> 00:59:26,360
Speaker 1: So thank you you well player.

1017
00:59:27,200 --> 00:59:30,080
Speaker 2: Excellent Jeff, keep up your great work. I'm sure there's

1018
00:59:30,120 --> 00:59:32,960
Speaker 2: so many people that will benefit. And uh, it's got

1019
00:59:32,960 --> 00:59:35,400
Speaker 2: to be very exciting to be just on the bleeding

1020
00:59:35,480 --> 00:59:35,919
Speaker 2: edge here.

1021
00:59:36,520 --> 00:59:38,200
Speaker 1: Great Thank you for having this has been great.

1022
00:59:38,720 --> 00:59:41,120
Speaker 2: I think I think you've got yourself at least one

1023
00:59:41,240 --> 00:59:43,680
Speaker 2: future patient out of this podcast. I can tell you

1024
00:59:43,760 --> 00:59:51,360
Speaker 2: that right now be happy to help you