WEBVTT - #2078 The Statin Delusion - David Gillespie

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<v Speaker 1>I get a team Craig Anthony Harper reporting in It's

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<v Speaker 1>four oh two, it's bloody, it's New Year's Eve, it's news.

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<v Speaker 1>I don't even know why we're recording today. Well I

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<v Speaker 1>do because I asked David and he's got no life

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<v Speaker 1>and I've got no life between the two of us,

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<v Speaker 1>los as we went. Fuck it, let's record an episode

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<v Speaker 1>of the Year project. Happy New Year, mate?

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<v Speaker 2>How are you?

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<v Speaker 3>Yeah? Good? How are you?

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<v Speaker 2>I'm good?

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<v Speaker 1>You don't I could get in trouble saying this, but

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<v Speaker 1>fuck it, I'll say. You don't strike me as the

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<v Speaker 1>super festive type. Am I right or wrong with that?

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<v Speaker 1>I think you're probably right. I don't tend to go

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<v Speaker 1>in for celebrating things. I guess yeah.

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<v Speaker 3>I'm also just quite happy if people ignore my birthday

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<v Speaker 3>and things like that too.

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<v Speaker 1>What, yeah, is that a personality thing with you? Is

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<v Speaker 1>that just a personal preference? Where have you always been

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<v Speaker 1>like that?

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<v Speaker 3>Like?

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<v Speaker 1>I can't ever see you despite the fact that you

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<v Speaker 1>have a profile and you're very public in a way,

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<v Speaker 1>you seem you don't seem like an introvert, but you

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<v Speaker 1>definitely seem like somebody who doesn't want to be in

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<v Speaker 1>the middle of a crowd or be the center of

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<v Speaker 1>attention at all, unlike a lot of other public figures.

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<v Speaker 3>Yeah, I've well, I guess maybe it's just laziness. I

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<v Speaker 3>think being the center of attention takes a lot of

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<v Speaker 3>work and is unnecessary for a lot of what I

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<v Speaker 3>have to do, in the sense that all the things

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<v Speaker 3>I've written about are really about providing people with knowledge

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<v Speaker 3>and the tools to do something about something in their lives.

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<v Speaker 3>Like I don't bother writing books, you know, clutching our

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<v Speaker 3>pearls and wringing our hands about climate change even though

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<v Speaker 3>it's very real and very dangerous and so on, because

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<v Speaker 3>I can't think of a way to write a book

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<v Speaker 3>that results in someone being able to meaningfully affect it.

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<v Speaker 3>And it's sort of something that I follow with everything

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<v Speaker 3>I write. The person has to be able to put

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<v Speaker 3>the book down and immediately implement something at a personal

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<v Speaker 3>level that changes something about their lives. And I guess

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<v Speaker 3>that doesn't need me to be an Instagram star to

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<v Speaker 3>do that. It just needs me to be accurate and constant.

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<v Speaker 3>And like I said, probably all boils down to laziness

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<v Speaker 3>in the end, because to be an Instagram star, I'd

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<v Speaker 3>have to do all sorts of things I quite frankly

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<v Speaker 3>wouldn't be comfortable doing, you know, tiktoks and videos and

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<v Speaker 3>unboxings and all that sort of crap.

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<v Speaker 2>Maybe yeah, I just think for you though, like.

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<v Speaker 1>I know, you've got a profile and you you know,

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<v Speaker 1>I guess if I asked ten people, have you heard

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<v Speaker 1>of David Gillespie, the author you know, Sweet Poison, blah

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<v Speaker 1>blah blah all that, I don't know. I think maybe

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<v Speaker 1>three or four ossies might have heard of you, compared

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<v Speaker 1>to none out of ten for me, which I'm fine with.

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<v Speaker 1>But I just think for you, the bigger the bigger

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<v Speaker 1>your social media presence, the more awareness around your messages,

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<v Speaker 1>Like if you had a million followers on Instagram, not

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<v Speaker 1>because you're dancing like a fuck with at a train

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<v Speaker 1>station or unwrapping a fucking you know, a high def

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<v Speaker 1>TV or I don't know.

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<v Speaker 2>Look here's here's my breakfast. Hey everyone, you know.

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<v Speaker 1>I mean, there's a lot of that, But I just think,

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<v Speaker 1>like for you, I actually get frustrated because your writing

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<v Speaker 1>is so brilliant, and I just think enough people don't

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<v Speaker 1>see it, and there's so much shit out there. There's

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<v Speaker 1>so much poor writing and poor information and misinformation that

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<v Speaker 1>is overexposed, you know. Yeah, And I guess I guess

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<v Speaker 1>I live in hope that you know, there's an old

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<v Speaker 1>saying and I can't remember who said it, probably Mark Twain.

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<v Speaker 3>He comes up with all the best ones. You know,

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<v Speaker 3>if it's really news, it'll find you. And I guess

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<v Speaker 3>I live in hope that if someone really needs to

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<v Speaker 3>hear anything I've got to say, there's enough of my

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<v Speaker 3>stuff out there in various places that they will find it.

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<v Speaker 3>And m I just you know, I'd love to have

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<v Speaker 3>a million followers on something, because, as you say, a

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<v Speaker 3>lot more people would read what I had to say.

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<v Speaker 3>But I'm not prepared to get into the churn that

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<v Speaker 3>is required to make that happen. So yeah, like I said,

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<v Speaker 3>it comes back to laziness.

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<v Speaker 2>Well, I think, yah, maybe maybe wisdom.

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<v Speaker 1>I think sometimes I put a fair bit of effort

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<v Speaker 1>into my Instagram, only my Instagram, not really Facebook or whatever.

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<v Speaker 1>And I've got across Facebook and Instagram over one hundred

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<v Speaker 1>thousand followers, which is a few, but it's not bizarre, right,

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<v Speaker 1>But sometimes I think for the time, effort and energy,

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<v Speaker 1>and also what's funny is sometimes I will write something

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<v Speaker 1>that is, you know, as close to profound.

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<v Speaker 2>As I'm going to get.

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<v Speaker 1>Like, it's quite deep and thoughtful, insightful, and potentially if

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<v Speaker 1>somebody would turn that theory into behavior.

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<v Speaker 2>It might be really valuable. And it'll get out of ten.

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<v Speaker 1>Let's say it gets a one response, and then I'll

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<v Speaker 1>put up I'll write on my whiteboard, don't be a

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<v Speaker 1>fucking idiot, and that'll get a nine.

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<v Speaker 2>Right. It's like the.

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<v Speaker 1>Stuff that is so base and so and it's almost

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<v Speaker 1>like the more I swear, the greater the response. In fact,

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<v Speaker 1>it's not. It's not like it is. There's a direct correlation.

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<v Speaker 1>And in fact, I think you've discovered.

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<v Speaker 3>You discovered Ricky Gervais's secret success.

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<v Speaker 1>Then I think I discovered before him. I mean, my

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<v Speaker 1>second book had fuck on the front cover, and that

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<v Speaker 1>was twenty ten, so that was fifteen years ago. And

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<v Speaker 1>that my subsequent book to that, which Penguin saw that

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<v Speaker 1>was just called stop Fucking Around thirty Principles for Blah

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<v Speaker 1>blah blah. Right, And Penguin saw that book and reached

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<v Speaker 1>out to me, which I know is not the normal

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<v Speaker 1>kind of protocol, and said, we had a look at it,

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<v Speaker 1>we liked it, and I sold a lot, right, I

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<v Speaker 1>sold a lot of that book, as you know, like

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<v Speaker 1>I think in Australia ten thousand is the best seller,

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<v Speaker 1>and it was way way, way more than that, with

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<v Speaker 1>no distribution, no publisher, al self published, no interviews, right,

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<v Speaker 1>And so they went, we want.

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<v Speaker 2>You to do a big version of that and.

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<v Speaker 1>Anyway, so I spent I got paid to write a book,

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<v Speaker 1>as you do, and.

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<v Speaker 2>Then I had to deliver it within one hundred and

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<v Speaker 2>eighty days, which I did. But blah blah blah blah.

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<v Speaker 1>I did all this stuff and then they named it

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<v Speaker 1>pull Your Finger Out, which I fucking hated. Right the

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<v Speaker 1>first one stopped fucking around, and this was meant to

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<v Speaker 1>be the bigger, better version.

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<v Speaker 2>I'm like, and I said to them, that's a terrible name.

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<v Speaker 1>And they're like, oh, you know, we've done all the whatever,

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<v Speaker 1>the testing out, you know, and it really tested well,

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<v Speaker 1>and I just said, it absolutely won't work. And I

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<v Speaker 1>don't know if you've ever done this, but I went

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<v Speaker 1>into Penguin and I sat down in a boardroom with

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<v Speaker 1>like ten people who worked on it and marketing and

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<v Speaker 1>branding and market research and all the you know, look

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<v Speaker 1>and feel and color and vibe, and which was great,

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<v Speaker 1>and they were great. Everything was great except the title,

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<v Speaker 1>and then that book, which was a much better book

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<v Speaker 1>in my opinion. I wrote both it it was outsold

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<v Speaker 1>by the first one six to one.

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<v Speaker 2>Yeah, just because it's a shit title, you know.

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<v Speaker 3>Well, yeah, and you will have discovered that it doesn't

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<v Speaker 3>matter what you think of the title. If you signed

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<v Speaker 3>a standard Penguins publication contract, they have entire control over

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<v Speaker 3>the title to cover everything that's on the front and

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<v Speaker 3>back cover, and you they ask you, out of courtesy

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<v Speaker 3>what you think of it. But if you it's a

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<v Speaker 3>pr exercise. If you say it sucks, I want something else,

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<v Speaker 3>they'll say, well, thank you for your input, and go

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<v Speaker 3>ahead and do what they were going to do.

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<v Speaker 1>Anyway, I told them like I sat in the boardroom

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<v Speaker 1>and they literally had this reveal where they had an

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<v Speaker 1>a frame with the book on the cover right so

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<v Speaker 1>that all the artwork, and they pulled off a sheet essentially,

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<v Speaker 1>and my first words were I hate it, and everyone

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<v Speaker 1>looked at me like, apparently you're not meant to say that,

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<v Speaker 1>But anyway.

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<v Speaker 3>I'm having a similar experience at the moment with the

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<v Speaker 3>title of my next book, which but I look, I

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<v Speaker 3>come from the position of I think, never having successfully

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<v Speaker 3>given a good title to anything, and so I have

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<v Speaker 3>no confidence in my ability to be any better at

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<v Speaker 3>it than they are. So, you know, no matter what

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<v Speaker 3>my opinion of their title, I doubt anything I would

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<v Speaker 3>come up with is any better. You know, I find

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<v Speaker 3>that even when in writing an article. You know, at

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<v Speaker 3>the end of writing an article, I have to think

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<v Speaker 3>of a title for it, and I'm usually pretty stumped

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<v Speaker 3>about what to call it. And I doubt I've cracked

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<v Speaker 3>the magic. You know, this is highly clickable if you

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<v Speaker 3>just call it this title. You know, for starters. I

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<v Speaker 3>don't use the word fucking any of the titles of

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<v Speaker 3>any of my pieces or books.

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<v Speaker 1>Well, you've gone okay, So I don't think, well, who knows,

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<v Speaker 1>I mean, you got you are going okay.

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<v Speaker 3>But maybe I should, Yeah, maybe I should. Do you

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<v Speaker 3>know there's that new thing on substack where they do

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<v Speaker 3>the what are they called the ab testing, where you

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<v Speaker 3>can give it alternate titles, and it spends the first

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<v Speaker 3>hour dividing up your audience with various titles and then

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<v Speaker 3>picks the one that worked the best. Maybe I should

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<v Speaker 3>try a few profanities and see what happens. Huh.

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<v Speaker 1>I did a just tongue in cheek, completely ridiculous. You know,

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<v Speaker 1>how you develop scales and then you get scales validated

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<v Speaker 1>over the time. So for my PhD I developed a scale,

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<v Speaker 1>but just for fun, I did another bullshit scale called

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<v Speaker 1>called the fuck scale, which is friendship, understanding, caring, and kindness.

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<v Speaker 1>And it was an emotional kind of investment scale friendship, understanding, caring,

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<v Speaker 1>and kindness and fuck was an acronym for those four words,

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<v Speaker 1>and it was like how many one to seven fucks

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<v Speaker 1>on a like art scale, like how many fucks do

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<v Speaker 1>you give?

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<v Speaker 2>Right? Anyway?

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<v Speaker 1>And it was just complete, Well, that went nuts my

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<v Speaker 1>actual scale that I put up, which is a psychometric

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<v Speaker 1>evaluation like a real one.

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<v Speaker 4>Yeah, whatever sounds boring this other one, you know, the

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<v Speaker 4>fuck scale, Oh my god. Anyway, it's what happens before

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<v Speaker 4>we talk about our actual topic, which will take.

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<v Speaker 2>Six minutes knowing you and me or more. I wanted

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<v Speaker 2>to ask you how would you label How would you

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<v Speaker 2>label your.

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<v Speaker 1>Books or your writing? Would you call it would you

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<v Speaker 1>call it self help, would you call it education? Would

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<v Speaker 1>you call it something else? Or would you call it

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<v Speaker 1>a synthesis of a few things?

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<v Speaker 3>It's education sound like I'm trying to lecture to people,

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<v Speaker 3>which I'm not. I really really hate Ritchie self help books,

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<v Speaker 3>you know, it did really really turned me off. I

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<v Speaker 3>sort of think of it more of you as invested

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<v Speaker 3>investigative journalism with some self help stuff or how to

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<v Speaker 3>apply this at the end of it. You know, so

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<v Speaker 3>this is all terribly interesting, but what does it mean

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<v Speaker 3>to you and me? And I don't like to just

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<v Speaker 3>do the research and not be able to do that,

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<v Speaker 3>and so it's yeah, it's mostly yeah, it's that it's

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<v Speaker 3>not education. Sounds a little bit creachy, like I'm trying

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<v Speaker 3>to teach you something, like like I know it and

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<v Speaker 3>you don't, and I've got to teach you. And usually

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<v Speaker 3>in my books, I don't know the answer before I start.

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<v Speaker 3>I just have a sense that there's something wrong in

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<v Speaker 3>what we're being told about how something works, and I

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<v Speaker 3>like to dig in, and the book ends up being

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<v Speaker 3>the documentation of what I found. And there's been many

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<v Speaker 3>starts at books where I find, actually what we're being

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<v Speaker 3>told about this is the sum of our knowledge on this,

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<v Speaker 3>and there is no other evidence. And so there really

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<v Speaker 3>is no point writing a book that says, well, you know,

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<v Speaker 3>everything the Heart Foundation says is absolutely correct.

0:13:31.800 --> 0:13:35.240
<v Speaker 1>You know who's buying that, yeah, yeah, or a book

0:13:35.320 --> 0:13:37.760
<v Speaker 1>that says, hey, the other books were right, You're welcome

0:13:38.080 --> 0:13:39.120
<v Speaker 1>the next time.

0:13:39.120 --> 0:13:42.640
<v Speaker 3>The less boat into it. I have looked into it

0:13:42.679 --> 0:13:43.600
<v Speaker 3>and they were right.

0:13:44.600 --> 0:13:49.480
<v Speaker 1>I can I can confirm your honor. Yeah, I for me,

0:13:49.640 --> 0:13:52.880
<v Speaker 1>one of them consider I was going to say battles.

0:13:52.920 --> 0:13:55.560
<v Speaker 1>It's not a fucking battle. But one of my constant

0:13:55.600 --> 0:13:59.840
<v Speaker 1>considerations is like, even like I did a gig recently

0:14:00.120 --> 0:14:03.640
<v Speaker 1>for actually for a supplement company down here, but it

0:14:03.720 --> 0:14:06.760
<v Speaker 1>wasn't We didn't talk about their supplements. It's just an

0:14:06.920 --> 0:14:13.800
<v Speaker 1>education night for blokes, you know, in that health, fitness, wellness, performance, aging,

0:14:14.080 --> 0:14:19.200
<v Speaker 1>anti aging, just general stuff, you know, food, exercise, lifestyle, sleep, stress, anxiety,

0:14:19.280 --> 0:14:24.840
<v Speaker 1>self management, all that stuff. And I'm constantly going, so,

0:14:24.920 --> 0:14:28.080
<v Speaker 1>here's something that's worth thinking about, or here's some information,

0:14:29.160 --> 0:14:31.680
<v Speaker 1>here's what we know, here's a bit of research. But

0:14:31.760 --> 0:14:33.480
<v Speaker 1>then I've kind of got to go so what can

0:14:33.520 --> 0:14:34.280
<v Speaker 1>we do about that?

0:14:34.320 --> 0:14:37.320
<v Speaker 2>Though? So that's all well and good, but now what

0:14:37.360 --> 0:14:39.840
<v Speaker 2>does that mean to do to you? And what can

0:14:39.880 --> 0:14:42.320
<v Speaker 2>you do with that? Because I think as well as

0:14:42.320 --> 0:14:48.720
<v Speaker 2>presenting potentially information and problems and current flowared thinking or

0:14:49.480 --> 0:14:50.360
<v Speaker 2>dodgy science.

0:14:50.440 --> 0:14:53.520
<v Speaker 1>You've still got to say. You've still got to give

0:14:53.560 --> 0:14:57.920
<v Speaker 1>them some hope or direction or information or some answers

0:14:58.000 --> 0:15:00.920
<v Speaker 1>that they might be able to, at the very least say, well,

0:15:00.960 --> 0:15:03.560
<v Speaker 1>I'm going to try this because what he spoke about,

0:15:03.600 --> 0:15:07.320
<v Speaker 1>I'm dealing with that. So starting tomorrow, I'm going to whatever.

0:15:07.320 --> 0:15:09.160
<v Speaker 1>I'm going to walk for fifteen minutes a day for

0:15:09.200 --> 0:15:10.960
<v Speaker 1>the next hundred days and see what happens.

0:15:11.000 --> 0:15:14.600
<v Speaker 2>You know, just so people have got a little bit

0:15:14.640 --> 0:15:15.680
<v Speaker 2>of an.

0:15:15.560 --> 0:15:20.000
<v Speaker 3>Action plan at least that applies generally except for the

0:15:20.040 --> 0:15:23.960
<v Speaker 3>topics like the one we're going to discus today, which

0:15:24.000 --> 0:15:28.640
<v Speaker 3>is about drugs. And you know, I don't want anyone

0:15:29.160 --> 0:15:31.520
<v Speaker 3>to be asking me, like you, for example, at the

0:15:31.600 --> 0:15:34.080
<v Speaker 3>end of what we discussed today, so what does this

0:15:34.200 --> 0:15:37.560
<v Speaker 3>mean we should do? Because my answer will be talk

0:15:37.560 --> 0:15:42.240
<v Speaker 3>to your doctor, because I don't want to get into

0:15:42.280 --> 0:15:45.480
<v Speaker 3>a space where I'm telling someone to take a drug

0:15:45.560 --> 0:15:49.880
<v Speaker 3>or not take a drug. In this particular space, what

0:15:50.000 --> 0:15:52.920
<v Speaker 3>we're talking about is what is the evidence actually say?

0:15:53.600 --> 0:15:58.720
<v Speaker 3>And I guess what does it say about us? Given

0:15:58.760 --> 0:15:59.320
<v Speaker 3>the evidence?

0:16:00.720 --> 0:16:03.360
<v Speaker 1>All right, well, let's jump into it. We're talking about writing.

0:16:03.440 --> 0:16:08.040
<v Speaker 1>Let's talk about some of your writing from a substack.

0:16:08.160 --> 0:16:11.000
<v Speaker 1>So this went up two days ago. It's called the

0:16:11.000 --> 0:16:14.480
<v Speaker 1>statin delusion. Everyone, So if you don't follow galspo and substack,

0:16:15.480 --> 0:16:18.760
<v Speaker 1>it's free and it's a great resource, so you should

0:16:18.760 --> 0:16:22.640
<v Speaker 1>definitely do that, all right, tell us about the statined delusion.

0:16:22.720 --> 0:16:25.480
<v Speaker 1>We are trading the remote possibility of a heart attack

0:16:26.080 --> 0:16:28.400
<v Speaker 1>for the certainty of metabolic decay.

0:16:28.680 --> 0:16:30.240
<v Speaker 2>Is the kind of subheading.

0:16:31.080 --> 0:16:34.560
<v Speaker 3>Yeah, so, and I start with an analogy in the

0:16:35.920 --> 0:16:40.120
<v Speaker 3>article and can read that. Go ahead, Yeah, yeah.

0:16:39.920 --> 0:16:42.240
<v Speaker 1>I think that might set it up nicely for people.

0:16:44.040 --> 0:16:46.240
<v Speaker 1>Imagine taking your car to the garage for a road

0:16:46.240 --> 0:16:50.680
<v Speaker 1>worthy certificate. The mechanics circles the vehicle and hums. He

0:16:50.720 --> 0:16:54.600
<v Speaker 1>admits the engineers in pristine. The engine is pristine, and

0:16:54.640 --> 0:16:58.760
<v Speaker 1>the car runs perfectly, but he insists on replacing the transmission.

0:16:59.160 --> 0:17:02.120
<v Speaker 1>This is not because is broken. It is because a

0:17:02.160 --> 0:17:06.400
<v Speaker 1>complex algorithm suggests a four percent chance it might shudder

0:17:06.680 --> 0:17:08.439
<v Speaker 1>in two thousand and thirty two.

0:17:08.600 --> 0:17:11.560
<v Speaker 2>That's funny. You'd call the police. You'd call him a

0:17:11.600 --> 0:17:12.359
<v Speaker 2>fraud and a thief.

0:17:12.440 --> 0:17:15.200
<v Speaker 1>Yet we thank doctors when they do the exact same

0:17:15.280 --> 0:17:19.399
<v Speaker 1>thing with our cardiovascular system. We then head to a chemist.

0:17:19.760 --> 0:17:22.600
<v Speaker 1>This is the state of modern medicine in Australia. We

0:17:22.640 --> 0:17:27.040
<v Speaker 1>are witnessing a monumental act in pharmaceutical theatrics. Health is

0:17:27.080 --> 0:17:30.080
<v Speaker 1>treated as a deficiency of medication.

0:17:31.000 --> 0:17:32.959
<v Speaker 2>All right, I could go on, but I'll let you

0:17:33.040 --> 0:17:33.560
<v Speaker 2>jump in.

0:17:34.040 --> 0:17:39.800
<v Speaker 3>So this is about statens and the interesting thing about

0:17:39.800 --> 0:17:43.040
<v Speaker 3>that so well, first of all, what are staturns. So

0:17:43.160 --> 0:17:46.960
<v Speaker 3>statins are the most prescribed drug in Australia today, the

0:17:47.119 --> 0:17:54.280
<v Speaker 3>most prescribed drug, and I think the stats are pretty extraordinary.

0:17:54.440 --> 0:18:00.320
<v Speaker 3>I think it's something like half of everybody over the

0:18:00.359 --> 0:18:02.880
<v Speaker 3>age of sixty five and a significant proportion of those

0:18:02.960 --> 0:18:06.240
<v Speaker 3>under the age of sixty five in Australia are on statins.

0:18:08.280 --> 0:18:10.840
<v Speaker 3>If a person is over the age of sixty five

0:18:10.840 --> 0:18:13.080
<v Speaker 3>and also has type two diabetes, they've got an eighty

0:18:13.119 --> 0:18:16.320
<v Speaker 3>percent chance of being on Staaten's in Australia. So statins

0:18:16.359 --> 0:18:20.040
<v Speaker 3>are handed out like lollipops at the fate. You know

0:18:20.119 --> 0:18:23.560
<v Speaker 3>this is this is a drug that is massively prescribed

0:18:23.600 --> 0:18:26.879
<v Speaker 3>in Australia. Australia is, by the way, the world leader

0:18:26.920 --> 0:18:29.480
<v Speaker 3>in the prescription of statns. There is no one who

0:18:29.520 --> 0:18:33.920
<v Speaker 3>prescribes more of them on a per capita basis than Australia,

0:18:34.600 --> 0:18:35.280
<v Speaker 3>and we've.

0:18:36.400 --> 0:18:38.640
<v Speaker 1>Just sorry for the ten people who are going, what

0:18:38.680 --> 0:18:41.200
<v Speaker 1>are they They treat high cholesterol, right.

0:18:41.480 --> 0:18:44.320
<v Speaker 3>So what they do. What they do is reduce the

0:18:44.440 --> 0:18:48.280
<v Speaker 3>level of LDL cholesterol, which is theoretically the bad cholesterol.

0:18:48.320 --> 0:18:52.840
<v Speaker 3>And we could go into why I say theoretically and

0:18:53.160 --> 0:18:58.280
<v Speaker 3>you're imagining parenthesis around the bad bit there, and we

0:18:58.359 --> 0:19:00.320
<v Speaker 3>might or we might not. We might leave that for

0:19:00.400 --> 0:19:04.680
<v Speaker 3>another show. But what they do is they do definitively

0:19:05.280 --> 0:19:07.439
<v Speaker 3>or a lot of people, not everyone, but for a

0:19:07.440 --> 0:19:12.119
<v Speaker 3>lot of people, lower the level of LDL cholesterol. And

0:19:12.680 --> 0:19:15.240
<v Speaker 3>if you've ever been to a doctor and had a

0:19:15.280 --> 0:19:19.399
<v Speaker 3>blood test, they'll they'll show you a print out that

0:19:19.480 --> 0:19:22.320
<v Speaker 3>will give you a level of LDL cholesterol. It will

0:19:22.359 --> 0:19:24.560
<v Speaker 3>give you sort of total cholesterol, also give you ld

0:19:24.640 --> 0:19:29.119
<v Speaker 3>old cholesterol and sometimes HDL cholesterol, which is theoretically the

0:19:29.160 --> 0:19:35.479
<v Speaker 3>good cholesterol. And Staton's lower for many people the number

0:19:35.640 --> 0:19:42.240
<v Speaker 3>LDL cholesterol. And for a long time now, the accepted

0:19:42.359 --> 0:19:47.800
<v Speaker 3>science has been that that's a good thing. That if

0:19:47.840 --> 0:19:51.240
<v Speaker 3>you lower people's ld OL cholesterol, it should present prevent

0:19:51.400 --> 0:19:55.919
<v Speaker 3>them having fatal heart attacks or any heart attacks, or

0:19:55.960 --> 0:19:57.720
<v Speaker 3>you know, should reduce the number of heart attacks they're

0:19:57.800 --> 0:19:59.600
<v Speaker 3>likely to have or reduce their risk of heart attack,

0:19:59.720 --> 0:20:02.439
<v Speaker 3>or any number of ways of spinning it, but in general,

0:20:02.480 --> 0:20:06.240
<v Speaker 3>the theory is that if you lower LDOL cholesterol, you

0:20:06.320 --> 0:20:13.520
<v Speaker 3>should have less cardiac events in your life. And initially

0:20:13.560 --> 0:20:16.119
<v Speaker 3>these drugs were used when they first sort of hit

0:20:16.160 --> 0:20:19.320
<v Speaker 3>the market in the nineteen eighties or late nineteen eighties

0:20:19.359 --> 0:20:22.960
<v Speaker 3>early nineteen nineties, they were initially used to give to

0:20:23.040 --> 0:20:27.520
<v Speaker 3>people who had already had a heart attack, so they've

0:20:27.560 --> 0:20:32.600
<v Speaker 3>had their first cardiac event, often young, younger people sort

0:20:32.600 --> 0:20:35.399
<v Speaker 3>of around you, under fifty or so, and they were

0:20:35.440 --> 0:20:40.000
<v Speaker 3>given to them as a way of presenting preventing further

0:20:40.080 --> 0:20:44.879
<v Speaker 3>cardiac events. And there were some early studies that suggested

0:20:44.920 --> 0:20:48.520
<v Speaker 3>that they were reasonably effective at that and honestly, those

0:20:48.560 --> 0:20:51.400
<v Speaker 3>studies have not to my knowledge, been debunked in any

0:20:51.440 --> 0:20:54.600
<v Speaker 3>great degree since then, despite some of the problems I'm

0:20:54.600 --> 0:21:01.200
<v Speaker 3>about to discuss with the studies. But the what has

0:21:01.240 --> 0:21:03.880
<v Speaker 3>happened though, is that the drug companies have taken that

0:21:04.320 --> 0:21:09.359
<v Speaker 3>glimmer of success. And you might imagine that people under

0:21:09.359 --> 0:21:12.040
<v Speaker 3>fifty who've had a heart attack, well it's actually only

0:21:12.080 --> 0:21:14.879
<v Speaker 3>men under fifty who've had a heart attack. The studies

0:21:14.880 --> 0:21:19.600
<v Speaker 3>didn't show any definitive benefit for women, but men under

0:21:19.640 --> 0:21:24.720
<v Speaker 3>fifty who've had a heart attack is a relatively small market,

0:21:26.119 --> 0:21:28.720
<v Speaker 3>and it's certainly not getting you anywhere near the numbers

0:21:28.760 --> 0:21:30.840
<v Speaker 3>I just gave you before. You know, with six out

0:21:30.880 --> 0:21:33.919
<v Speaker 3>of ten people over the age of sixty five taking

0:21:33.920 --> 0:21:36.760
<v Speaker 3>a drug every day of the week, you're not getting

0:21:36.760 --> 0:21:40.920
<v Speaker 3>near that. So the drug companies managed to convert that

0:21:41.040 --> 0:21:46.879
<v Speaker 3>glimmer of success into over the last thirty years, a

0:21:46.960 --> 0:21:51.680
<v Speaker 3>widespread program of everyone being given or as many people

0:21:51.680 --> 0:21:54.919
<v Speaker 3>as possible being given these things as a preventative measure.

0:21:55.440 --> 0:21:58.320
<v Speaker 3>So you might feel perfectly well. And this is why

0:21:58.359 --> 0:22:01.399
<v Speaker 3>I use the mechanic analogy. The start, you might feel

0:22:01.440 --> 0:22:04.840
<v Speaker 3>perfectly well. It might you might look perfectly well. There

0:22:04.920 --> 0:22:07.000
<v Speaker 3>might be nothing wrong with your heart to you know,

0:22:07.040 --> 0:22:10.280
<v Speaker 3>the casual observer or the medical observer, but you never know,

0:22:11.080 --> 0:22:16.120
<v Speaker 3>you know, just in case, just in case, take this thing,

0:22:16.640 --> 0:22:20.000
<v Speaker 3>and you know it'll it'll reduce your risk of ever

0:22:20.040 --> 0:22:20.959
<v Speaker 3>having a heart attack.

0:22:21.680 --> 0:22:25.280
<v Speaker 1>Well, based on that logic, I should wear my motorcycle

0:22:25.359 --> 0:22:27.919
<v Speaker 1>helmet on and off the motorbike. I should wear that

0:22:28.000 --> 0:22:32.359
<v Speaker 1>around the house pretty much, same logic, exact same logic, Yeah,

0:22:32.480 --> 0:22:38.040
<v Speaker 1>which is you just never know. And even though you've

0:22:38.040 --> 0:22:40.200
<v Speaker 1>never had a heart attack and you don't seem to

0:22:40.240 --> 0:22:43.080
<v Speaker 1>be at risk of having a heart attack, why not

0:22:44.560 --> 0:22:46.960
<v Speaker 1>And if these and if the drugs that we're talking

0:22:46.960 --> 0:22:51.120
<v Speaker 1>about were completely harmless, like if I was talking about

0:22:51.200 --> 0:22:52.320
<v Speaker 1>here was a sugar pill.

0:22:54.040 --> 0:22:58.200
<v Speaker 3>And it made people feel better to take one every day,

0:22:58.359 --> 0:23:01.600
<v Speaker 3>to you know, you say, oh, you know, I've said

0:23:01.680 --> 0:23:03.640
<v Speaker 3>my three hele Mary's and I've taken a sugar pill,

0:23:03.680 --> 0:23:06.600
<v Speaker 3>So I'm definitely not having a heart attack today. That's

0:23:07.520 --> 0:23:10.000
<v Speaker 3>that would be fine. People can believe what they want

0:23:10.040 --> 0:23:14.760
<v Speaker 3>to believe, but these are not harmless. Their mechanism of

0:23:14.800 --> 0:23:20.320
<v Speaker 3>action is to shut down the liver's production of something

0:23:20.320 --> 0:23:23.880
<v Speaker 3>which is used to produce cholesterol called coenzyme Q ten.

0:23:25.320 --> 0:23:28.840
<v Speaker 3>So coenzyme Q ten you might have heard of before

0:23:28.880 --> 0:23:33.160
<v Speaker 3>if you've ever seen any cosmetics commercials, because it's often

0:23:33.200 --> 0:23:35.480
<v Speaker 3>touted as being something that you want to rub on

0:23:35.520 --> 0:23:38.760
<v Speaker 3>your skin or something. I've never quite followed the logic

0:23:38.800 --> 0:23:43.160
<v Speaker 3>of that, but it's it is actually a pretty handy

0:23:43.200 --> 0:23:44.960
<v Speaker 3>thing to have in your body. It's it's kind of

0:23:45.000 --> 0:23:49.480
<v Speaker 3>regarded in medicine as the starter motor for your cellular metabolism.

0:23:50.320 --> 0:23:54.520
<v Speaker 3>So it's it's the spark that gets cells producing the

0:23:54.600 --> 0:23:58.960
<v Speaker 3>right level of energy, and it's all. It does some

0:23:59.000 --> 0:24:01.000
<v Speaker 3>other things as well as as always the body never

0:24:01.080 --> 0:24:04.479
<v Speaker 3>just does one thing with anything, you know, and some

0:24:04.800 --> 0:24:06.880
<v Speaker 3>one of the others is that it is a very

0:24:06.960 --> 0:24:12.520
<v Speaker 3>very powerful antioxidant. So, and antioxidants are pretty handy. You

0:24:12.520 --> 0:24:17.800
<v Speaker 3>will recall from how many discussions about cancer that antioxidants

0:24:17.800 --> 0:24:21.080
<v Speaker 3>are a big part of stopping that happening because they

0:24:23.240 --> 0:24:26.320
<v Speaker 3>reduce the potential for oxidation within the system, particularly when

0:24:26.320 --> 0:24:29.200
<v Speaker 3>you take things that oxidize easily like seed oils. But

0:24:29.240 --> 0:24:31.560
<v Speaker 3>that's a little bit of the side So the mechanism

0:24:31.640 --> 0:24:34.240
<v Speaker 3>of action for Staton, though, is that they shut down

0:24:34.240 --> 0:24:38.639
<v Speaker 3>the production of coenzon q ten. So, as you might imagine,

0:24:38.960 --> 0:24:43.399
<v Speaker 3>there could be side effects, and the side effects have

0:24:43.480 --> 0:24:46.520
<v Speaker 3>started to become really quite apparent. There's a significant increase

0:24:46.600 --> 0:24:49.600
<v Speaker 3>nine percent increase in the incidence of type two diabetes

0:24:49.720 --> 0:24:53.800
<v Speaker 3>because apparently coinzon q ten is pretty handy in the pancreas,

0:24:55.000 --> 0:24:58.560
<v Speaker 3>and so there is a significant It's so much so

0:24:58.680 --> 0:25:00.960
<v Speaker 3>that the FDA and the United States now requires a

0:25:01.000 --> 0:25:07.320
<v Speaker 3>warning on statins to say that to say that there's

0:25:07.359 --> 0:25:13.080
<v Speaker 3>also many people who take statan's report muscle pain, and

0:25:13.359 --> 0:25:18.040
<v Speaker 3>it's often the reason that people stop taking them. You know,

0:25:18.160 --> 0:25:20.639
<v Speaker 3>much of the spare of the medical profession. You know,

0:25:20.880 --> 0:25:23.240
<v Speaker 3>they call that non compliance. Well, a big reason for

0:25:23.320 --> 0:25:26.439
<v Speaker 3>non compliance is that people experience muscle pain. Some of

0:25:26.480 --> 0:25:29.560
<v Speaker 3>the studies have shown that it's around twenty percent one

0:25:29.600 --> 0:25:34.160
<v Speaker 3>in five people taking statin's experience study experience muscle pain.

0:25:34.760 --> 0:25:38.920
<v Speaker 3>There's some interesting new evidence that suggests that they also

0:25:39.000 --> 0:25:42.680
<v Speaker 3>increase the incidence of stroke, which is a bit ironic

0:25:43.040 --> 0:25:46.960
<v Speaker 3>because you know, it's sort of training avoiding heart disease

0:25:47.880 --> 0:25:52.119
<v Speaker 3>and acquiring a risk of stroke. And these are all

0:25:52.240 --> 0:25:55.720
<v Speaker 3>quite concerning things for something that you may not need

0:25:55.760 --> 0:25:58.879
<v Speaker 3>to be taking at all in the first place. And

0:26:00.200 --> 0:26:05.040
<v Speaker 3>the problem here is with the evidence. Now there's precious

0:26:05.840 --> 0:26:11.160
<v Speaker 3>little objective evidence about the effectiveness of statins, and that's

0:26:11.160 --> 0:26:16.200
<v Speaker 3>because of a really peculiar arrangement between the drug companies

0:26:16.960 --> 0:26:23.160
<v Speaker 3>and the research group who are responsible for I think

0:26:23.200 --> 0:26:26.800
<v Speaker 3>it's twenty seven out of twenty eight of the major

0:26:26.840 --> 0:26:33.399
<v Speaker 3>statin trials analyzed and reported on by something called the

0:26:33.400 --> 0:26:36.959
<v Speaker 3>Clinical Trial Service Unit, which is part of the University

0:26:36.960 --> 0:26:41.359
<v Speaker 3>of Oxford. It's a joint thing between the NHMRC in

0:26:41.400 --> 0:26:45.720
<v Speaker 3>Australia and the University of Oxford, and so almost all

0:26:45.760 --> 0:26:48.960
<v Speaker 3>the data we have on the efficacy of statins comes

0:26:49.119 --> 0:26:53.439
<v Speaker 3>from this group, which in itself isn't necessarily a problem

0:26:53.520 --> 0:26:55.320
<v Speaker 3>except when you start to digging in a little about

0:26:55.760 --> 0:27:00.600
<v Speaker 3>how they're funded. So they're funded essentially by the companies

0:27:01.600 --> 0:27:07.240
<v Speaker 3>and they which once again you'd say, okay, well, that's

0:27:07.280 --> 0:27:08.720
<v Speaker 3>a cause for concerns, So we need to be a

0:27:08.760 --> 0:27:12.400
<v Speaker 3>little bit careful about anything that they say, particularly when

0:27:12.480 --> 0:27:15.439
<v Speaker 3>what they say seems to be at odds with the

0:27:15.480 --> 0:27:20.800
<v Speaker 3>few independent studies that have been done. But maybe that's

0:27:20.800 --> 0:27:22.919
<v Speaker 3>a coincidence, So you need to dig a little bit

0:27:22.960 --> 0:27:26.720
<v Speaker 3>further than that. And one of the big concerns about

0:27:26.720 --> 0:27:30.679
<v Speaker 3>this group is that they never publish the original data,

0:27:30.880 --> 0:27:33.919
<v Speaker 3>the raw data that is being used in the trials,

0:27:34.000 --> 0:27:38.920
<v Speaker 3>So they'll publish their interpretation of the data, but never

0:27:38.960 --> 0:27:41.960
<v Speaker 3>the actual data, so other scientists can't look at the

0:27:42.040 --> 0:27:45.080
<v Speaker 3>data and see if they agree with the conclusions that

0:27:45.080 --> 0:27:45.760
<v Speaker 3>they've come out.

0:27:46.560 --> 0:27:50.720
<v Speaker 1>How is that I mean as and I know, I

0:27:50.800 --> 0:27:53.320
<v Speaker 1>know we've established that psychology is not real And my

0:27:53.440 --> 0:27:57.080
<v Speaker 1>PhD is essentially analogous to getting a Barista qualification.

0:27:57.520 --> 0:27:58.560
<v Speaker 2>We've sorted out.

0:27:58.960 --> 0:28:01.800
<v Speaker 3>But you can make more money with it though.

0:28:02.320 --> 0:28:06.280
<v Speaker 1>Yeah, no, I know, I know, hello, Barista school, it's ups.

0:28:08.200 --> 0:28:11.800
<v Speaker 2>But how is that even a thing?

0:28:12.119 --> 0:28:16.400
<v Speaker 1>Where like, how in twenty twenty five can we have

0:28:16.520 --> 0:28:24.320
<v Speaker 1>companies that have got an extremely huge financial interest in

0:28:24.400 --> 0:28:29.720
<v Speaker 1>the outcome of the research fund the research, knowing that,

0:28:30.600 --> 0:28:35.679
<v Speaker 1>with the academic institution knowing that should they produce data

0:28:35.720 --> 0:28:41.080
<v Speaker 1>that doesn't align with the wants of the bank, the

0:28:41.120 --> 0:28:45.200
<v Speaker 1>pharmaceutical bank, then they're going to get funding cut. I mean,

0:28:45.800 --> 0:28:49.280
<v Speaker 1>it's just like that. Just isn't how science. I mean

0:28:49.320 --> 0:28:53.120
<v Speaker 1>to me, that's not science at all. There's no objectivity

0:28:53.160 --> 0:28:56.400
<v Speaker 1>there like that just and I don't just mean with

0:28:56.480 --> 0:29:00.080
<v Speaker 1>pharma college or pharmaceutical industry, but with all of it.

0:29:00.320 --> 0:29:01.640
<v Speaker 2>Like, if something's.

0:29:01.240 --> 0:29:04.720
<v Speaker 1>Funded by a group that has a financial interest in

0:29:04.760 --> 0:29:07.280
<v Speaker 1>the outcome of the science, who's going to believe that?

0:29:07.440 --> 0:29:10.240
<v Speaker 2>And why is that still a thing? Yeah?

0:29:10.280 --> 0:29:13.280
<v Speaker 3>Well, a good question. This is probably the most egregious

0:29:13.320 --> 0:29:19.560
<v Speaker 3>example of it, but it is rife. There are enormous

0:29:19.640 --> 0:29:24.400
<v Speaker 3>numbers of trials that are covertly funded by Coca Cola

0:29:24.480 --> 0:29:27.280
<v Speaker 3>and Pepsi and some on that come to the conclusion

0:29:27.320 --> 0:29:31.280
<v Speaker 3>that there's nothing wrong with sugar. And you know, they

0:29:31.280 --> 0:29:34.000
<v Speaker 3>don't say this is Cooke's trial on this this is

0:29:34.080 --> 0:29:36.840
<v Speaker 3>you know, it comes from a reputable university, and the

0:29:36.880 --> 0:29:40.640
<v Speaker 3>fundings come from something called ICSI. I can't remember the

0:29:40.680 --> 0:29:44.640
<v Speaker 3>acronym stand for, but it's an international research thing, and

0:29:44.800 --> 0:29:47.800
<v Speaker 3>you have to dig pretty hard to find out who's

0:29:47.840 --> 0:29:50.000
<v Speaker 3>actually paying for it. And you have to really understand

0:29:50.080 --> 0:29:53.000
<v Speaker 3>the study to understand how they've bent the rules a

0:29:53.040 --> 0:29:55.120
<v Speaker 3>bit to make sure that they get the result they want.

0:29:56.160 --> 0:29:59.360
<v Speaker 3>And on that point, one of the big criticisms of

0:29:59.440 --> 0:30:02.800
<v Speaker 3>the studies that these folks produce is that they use

0:30:03.280 --> 0:30:06.480
<v Speaker 3>a way of measuring the results which is not standard.

0:30:07.720 --> 0:30:10.840
<v Speaker 3>So in a normal trial, you just go head to head,

0:30:10.840 --> 0:30:12.840
<v Speaker 3>you say, right, we've got a thousand people taking the drug,

0:30:12.880 --> 0:30:15.720
<v Speaker 3>we've got a thousand people taking the placebo. Let's measure

0:30:15.720 --> 0:30:18.840
<v Speaker 3>the outcomes. You think that would be the That's called

0:30:18.840 --> 0:30:23.360
<v Speaker 3>an intention to treat trial, and that's the way most

0:30:23.360 --> 0:30:26.719
<v Speaker 3>science is done if you want a placebo controlled trial,

0:30:26.760 --> 0:30:30.200
<v Speaker 3>which is what you do with the drug, right, But

0:30:30.240 --> 0:30:33.320
<v Speaker 3>that's not how they do it. So what they do

0:30:33.720 --> 0:30:38.680
<v Speaker 3>is they report their results based on the degree of

0:30:38.840 --> 0:30:42.560
<v Speaker 3>responsiveness to the drug. So the amount that the person's

0:30:42.920 --> 0:30:47.000
<v Speaker 3>LDL was reduced, and they put them in one group

0:30:47.560 --> 0:30:50.600
<v Speaker 3>and the people whose LDL wasn't reduced in another group.

0:30:51.080 --> 0:30:55.800
<v Speaker 3>And these crossover both of the people with the perceibo

0:30:56.160 --> 0:30:57.840
<v Speaker 3>and the non perceivo on. Because you can't see the

0:30:57.880 --> 0:31:01.280
<v Speaker 3>original data, you don't know which is which, and they're

0:31:01.360 --> 0:31:06.960
<v Speaker 3>just saying, of the people whose LDL was reduced, we

0:31:07.000 --> 0:31:13.360
<v Speaker 3>report that they had, you know, ten percent lower incidents

0:31:13.400 --> 0:31:17.720
<v Speaker 3>of maya cardial events ten years later or something like that.

0:31:18.160 --> 0:31:21.200
<v Speaker 3>And because you can't look at the original data and

0:31:21.240 --> 0:31:25.600
<v Speaker 3>you can't essentially do what any study would do, which

0:31:25.640 --> 0:31:27.840
<v Speaker 3>is just put the people who took the perceibo versus

0:31:27.880 --> 0:31:30.040
<v Speaker 3>the people who took the drug side by side and

0:31:30.080 --> 0:31:33.320
<v Speaker 3>see the outcomes, you've just got this muddy in. And

0:31:33.720 --> 0:31:36.800
<v Speaker 3>there is a strong suspicion amongst many researchers that the

0:31:36.840 --> 0:31:40.440
<v Speaker 3>reason it's done that way is to make it that

0:31:40.520 --> 0:31:43.480
<v Speaker 3>you get a positive outcome for statins from their trials

0:31:43.760 --> 0:31:50.120
<v Speaker 3>that otherwise would not be there. So it's that's why

0:31:50.680 --> 0:31:53.600
<v Speaker 3>there's concern in this area. Now there are studies done

0:31:53.840 --> 0:31:57.840
<v Speaker 3>by independent groups. There are independent groups of scientists who

0:31:57.880 --> 0:32:00.320
<v Speaker 3>have looked at as much data as they can find

0:32:00.360 --> 0:32:03.400
<v Speaker 3>on this. Have tried to work back from the data

0:32:03.400 --> 0:32:05.800
<v Speaker 3>that is published about this and have come to the

0:32:05.840 --> 0:32:14.640
<v Speaker 3>conclusion that there's by and large no real preventative benefit.

0:32:15.680 --> 0:32:19.040
<v Speaker 3>They would agree there is a benefit to people who

0:32:19.040 --> 0:32:22.440
<v Speaker 3>have already had a heart attack. There is a benefit.

0:32:22.720 --> 0:32:25.720
<v Speaker 3>It is not a huge one, but there is one. Yes,

0:32:26.000 --> 0:32:29.000
<v Speaker 3>But they would say there just isn't data there to

0:32:29.520 --> 0:32:33.560
<v Speaker 3>support the notion that people taking these things as a

0:32:33.600 --> 0:32:37.640
<v Speaker 3>prophylactic you know, or you you with your motiviing helmet,

0:32:38.280 --> 0:32:41.840
<v Speaker 3>it just makes any difference whatsoever There might even be

0:32:42.080 --> 0:32:45.880
<v Speaker 3>There might even be an argument depending on who's taking it.

0:32:46.160 --> 0:32:50.000
<v Speaker 3>You know, somebody with no history of anything, who's relatively

0:32:50.040 --> 0:32:55.240
<v Speaker 3>fit and healthy and forty years old, the risks might

0:32:55.320 --> 0:32:59.600
<v Speaker 3>be greater than the potential benefits even well, exactly because

0:32:59.600 --> 0:33:01.720
<v Speaker 3>of the risk that I outlined before. So we're talking

0:33:01.720 --> 0:33:06.240
<v Speaker 3>about things like hemorrhagic stroke, type two diabetes. So those

0:33:06.280 --> 0:33:10.560
<v Speaker 3>type two diabetes incidences are relative increase over a person

0:33:10.560 --> 0:33:14.000
<v Speaker 3>who would never have gotten it before. So this is

0:33:14.040 --> 0:33:16.240
<v Speaker 3>a brand new disease that they would not have been

0:33:16.840 --> 0:33:19.800
<v Speaker 3>likely to get prior to taking the drug. And this

0:33:19.880 --> 0:33:23.719
<v Speaker 3>has been established beyond doubt in the research. So you know,

0:33:24.200 --> 0:33:28.600
<v Speaker 3>hemorrhagic stroke, type two diabetes, massive incidents of muscle pain

0:33:28.680 --> 0:33:32.000
<v Speaker 3>one in five with muscle pain that is significant. There's

0:33:32.040 --> 0:33:38.320
<v Speaker 3>some evidence of cognitive decline making dementia worse, so you know,

0:33:38.440 --> 0:33:41.880
<v Speaker 3>it's there are certainly a list of things that we

0:33:41.920 --> 0:33:44.040
<v Speaker 3>should be a bit concerned about with these things, which

0:33:44.080 --> 0:33:46.600
<v Speaker 3>is why I say these are not lollies, these are

0:33:46.600 --> 0:33:49.520
<v Speaker 3>not placebos. It does matter if you take it if

0:33:49.520 --> 0:33:53.160
<v Speaker 3>you don't need to take it. And then besides all

0:33:53.200 --> 0:33:57.840
<v Speaker 3>of this, we've also had a persistent moving of the

0:33:57.880 --> 0:34:02.880
<v Speaker 3>goalposts in terms of what is the target level of LDL.

0:34:03.600 --> 0:34:06.120
<v Speaker 3>So and I put a bit of a history of

0:34:06.160 --> 0:34:09.960
<v Speaker 3>this in the in the article where they you know

0:34:10.719 --> 0:34:13.759
<v Speaker 3>where the goalposts have been moving. The target started at

0:34:13.760 --> 0:34:20.240
<v Speaker 3>three point five and has moved so that these numbers,

0:34:20.280 --> 0:34:22.320
<v Speaker 3>by the way, are the standard numbers that appear on

0:34:22.640 --> 0:34:28.040
<v Speaker 3>Australian you know, blood reports. So when these drugs first

0:34:28.040 --> 0:34:31.200
<v Speaker 3>came out, if you had a total cholesterol count of

0:34:31.400 --> 0:34:34.160
<v Speaker 3>six point five million miles per later you were given

0:34:34.160 --> 0:34:35.680
<v Speaker 3>a clean bill of health and cent on your way.

0:34:37.160 --> 0:34:39.879
<v Speaker 3>But then they said they started moving the target on

0:34:39.880 --> 0:34:42.399
<v Speaker 3>once they discovered LDL and started to be able to say, oh,

0:34:42.440 --> 0:34:44.200
<v Speaker 3>this is the magic thing that needs to be fixed.

0:34:45.239 --> 0:34:47.080
<v Speaker 3>They started at the target of you want to get

0:34:47.080 --> 0:34:50.520
<v Speaker 3>it at three point five, and then it moved to

0:34:50.600 --> 0:34:54.200
<v Speaker 3>two point five, then to one point eight, and today

0:34:54.200 --> 0:34:59.719
<v Speaker 3>it's one point four. So each movement of this target

0:35:00.480 --> 0:35:04.000
<v Speaker 3>increases the number of people in the population who the

0:35:04.080 --> 0:35:08.600
<v Speaker 3>target would suggest need to have this thing right, and

0:35:08.640 --> 0:35:12.000
<v Speaker 3>so steadily, not surprisingly, the number of people in the

0:35:12.040 --> 0:35:16.920
<v Speaker 3>population being prescribed to these things has increased very rapidly,

0:35:17.000 --> 0:35:19.120
<v Speaker 3>until now we are, as I said, top of the

0:35:19.200 --> 0:35:23.399
<v Speaker 3>league in the OECD, We now prescribe more statons per

0:35:23.440 --> 0:35:28.239
<v Speaker 3>person than anyone else in the world. Yes, so, and

0:35:28.280 --> 0:35:31.600
<v Speaker 3>that's a direct result of you know, the well meaning

0:35:31.680 --> 0:35:35.280
<v Speaker 3>GP down the road he sees the official target. Oh,

0:35:35.320 --> 0:35:37.719
<v Speaker 3>it was three point five and now it's one point four.

0:35:38.080 --> 0:35:41.399
<v Speaker 3>I guess before I barely had any patients that were,

0:35:41.719 --> 0:35:43.359
<v Speaker 3>you know, needing to have these things, and now they

0:35:43.480 --> 0:35:44.560
<v Speaker 3>now suddenly all of them do.

0:35:45.600 --> 0:35:48.040
<v Speaker 2>Yeah, yeah, yeah.

0:35:48.120 --> 0:35:50.160
<v Speaker 1>I was just as you were talking, I was trying

0:35:50.160 --> 0:35:53.040
<v Speaker 1>to find I don't know if you've seen you don't

0:35:53.080 --> 0:35:56.719
<v Speaker 1>look at social media much, but it came across my

0:35:57.320 --> 0:36:01.319
<v Speaker 1>or it came to my attention this these papers, that

0:36:01.400 --> 0:36:04.320
<v Speaker 1>these I think it was two guys wrote based purely

0:36:04.400 --> 0:36:08.040
<v Speaker 1>on fraudulent data and fraud, like the whole thing was bullshit.

0:36:08.880 --> 0:36:14.359
<v Speaker 1>So they wrote these papers on these stupid topics, but

0:36:14.440 --> 0:36:18.960
<v Speaker 1>really well written. They are academics, really well written. And

0:36:19.080 --> 0:36:21.400
<v Speaker 1>these papers there was I think it was like nine

0:36:21.400 --> 0:36:24.759
<v Speaker 1>of them got published in like Tier one and two,

0:36:25.400 --> 0:36:29.240
<v Speaker 1>which for my listeners is kind of the gold standard

0:36:29.280 --> 0:36:35.960
<v Speaker 1>Tier one anyway, papers journals, and I just wonder how

0:36:36.040 --> 0:36:38.640
<v Speaker 1>much stuff. And I was just looking then at some

0:36:38.800 --> 0:36:41.920
<v Speaker 1>of the stuff I was trying to find. I was

0:36:41.920 --> 0:36:44.080
<v Speaker 1>trying to find those I can't, but I wonder how

0:36:44.160 --> 0:36:50.560
<v Speaker 1>much just fabrication and kind of you know, I don't know,

0:36:51.239 --> 0:36:55.200
<v Speaker 1>bending bending of the rules, but bending of the truth

0:36:55.280 --> 0:36:58.000
<v Speaker 1>goes on in trying to put these papers together. And

0:36:58.440 --> 0:37:01.399
<v Speaker 1>like I know, one of my friends is going through

0:37:01.440 --> 0:37:04.640
<v Speaker 1>this thing now where they're looking at the data and

0:37:04.680 --> 0:37:07.719
<v Speaker 1>the data is not telling him a lot with his research,

0:37:07.960 --> 0:37:10.600
<v Speaker 1>and so they because he has to produce a paper,

0:37:11.400 --> 0:37:15.719
<v Speaker 1>and he's desperately it's not me, by the way, but

0:37:16.440 --> 0:37:21.080
<v Speaker 1>desperately trying to find something to write a paper on

0:37:21.360 --> 0:37:25.560
<v Speaker 1>and to find some kind of correlation between A and.

0:37:25.480 --> 0:37:30.279
<v Speaker 2>B, because sometimes there's sometimes it just tells you fuck all, Well.

0:37:30.160 --> 0:37:33.200
<v Speaker 3>There's nothing more boring than you have a hypothesis that

0:37:34.280 --> 0:37:36.640
<v Speaker 3>you know, if you do a then B happens, and

0:37:36.680 --> 0:37:38.319
<v Speaker 3>then you go and measure it all and you find

0:37:38.360 --> 0:37:43.200
<v Speaker 3>out that it doesn't, and then your paper consists of, well,

0:37:43.200 --> 0:37:44.160
<v Speaker 3>I guess I was wrong.

0:37:45.200 --> 0:37:49.160
<v Speaker 2>Yeah, yeah, essentially essentially.

0:37:49.480 --> 0:37:51.120
<v Speaker 3>I mean, and we've seen a bit of that in

0:37:51.160 --> 0:37:54.080
<v Speaker 3>the in the in the research on and this comes

0:37:54.080 --> 0:37:55.799
<v Speaker 3>back to this point about the importance of being able

0:37:55.800 --> 0:37:58.560
<v Speaker 3>to see the underlying data. So there was a massive

0:38:00.080 --> 0:38:02.719
<v Speaker 3>study done back in the days when governments did spend

0:38:02.719 --> 0:38:04.640
<v Speaker 3>a lot of money on this sort of thing because

0:38:04.640 --> 0:38:08.000
<v Speaker 3>of the heart disease was absolutely peaking in the late

0:38:08.120 --> 0:38:12.360
<v Speaker 3>nineteen sixties in the United States, the massive rates of

0:38:12.400 --> 0:38:15.520
<v Speaker 3>increase of heart disease. We now know that that was

0:38:15.520 --> 0:38:18.440
<v Speaker 3>because of the massive rates of smoking. But even to

0:38:18.440 --> 0:38:20.279
<v Speaker 3>this day, no one's going to admit that they still

0:38:20.280 --> 0:38:22.520
<v Speaker 3>want to pin it with saturated fat. But they did

0:38:23.239 --> 0:38:31.120
<v Speaker 3>these huge studies where they Minnesota County Experiment for example.

0:38:31.520 --> 0:38:32.880
<v Speaker 3>I can't remember how I think it was close to

0:38:32.880 --> 0:38:36.400
<v Speaker 3>one hundred thousand people were enrolled in it. I can

0:38:36.400 --> 0:38:38.880
<v Speaker 3>you imagine the cost of doing something like that for

0:38:39.000 --> 0:38:43.120
<v Speaker 3>years on end, where they were having half the people

0:38:43.239 --> 0:38:47.000
<v Speaker 3>were eating a normal saturated fat diet and the other

0:38:47.080 --> 0:38:49.600
<v Speaker 3>half had a lower fat diet or eating seed oils

0:38:49.640 --> 0:38:53.640
<v Speaker 3>instead or things like that, and they measured and their

0:38:53.680 --> 0:38:56.440
<v Speaker 3>hypothesis was that the people who were eating the lower

0:38:56.480 --> 0:39:02.080
<v Speaker 3>fat diet and the polyon saturates, etc. Would have less

0:39:02.520 --> 0:39:05.919
<v Speaker 3>coronary events than the people eating the normal the butter,

0:39:05.960 --> 0:39:09.520
<v Speaker 3>the cheese, the milk, et cetera. And it turned out

0:39:09.520 --> 0:39:14.000
<v Speaker 3>it didn't, and so they never published. So this thing

0:39:14.600 --> 0:39:18.400
<v Speaker 3>went on at enormous expense for I think four years,

0:39:19.080 --> 0:39:24.719
<v Speaker 3>huge numbers of people involved, large, you know, and they

0:39:24.719 --> 0:39:29.200
<v Speaker 3>put out a paper that essentially said nothing, so essentially

0:39:29.520 --> 0:39:34.400
<v Speaker 3>didn't publish at all. Recently, the National Institutes of Health

0:39:35.000 --> 0:39:38.680
<v Speaker 3>reinvestigated that and had access to the original data, so

0:39:38.719 --> 0:39:42.440
<v Speaker 3>they went back into the archives, they dug up the data,

0:39:42.520 --> 0:39:45.080
<v Speaker 3>and they did their own reanalysis of it without all

0:39:45.080 --> 0:39:47.040
<v Speaker 3>the preconceptions of the people who were running it in

0:39:47.080 --> 0:39:50.240
<v Speaker 3>the first place, which was to find that eating saturated

0:39:50.280 --> 0:39:54.560
<v Speaker 3>fat cause heart disease. What they found was in fact

0:39:54.560 --> 0:39:56.880
<v Speaker 3>the opposite. What they found was that when you properly

0:39:56.920 --> 0:40:00.000
<v Speaker 3>analyze the data, the people who had more heart disease,

0:40:00.239 --> 0:40:03.160
<v Speaker 3>and in fact the people who died more often. So

0:40:03.239 --> 0:40:05.880
<v Speaker 3>the higher mortality rate was with the people who were

0:40:06.000 --> 0:40:09.439
<v Speaker 3>not eating the standard saturated fat diet, the people who

0:40:09.480 --> 0:40:12.680
<v Speaker 3>were lowering the cholesterol, the people who were having less

0:40:12.680 --> 0:40:15.439
<v Speaker 3>fat and on actually had not just a higher rate

0:40:15.520 --> 0:40:18.960
<v Speaker 3>of cronary events leading to death, but a higher rate

0:40:19.040 --> 0:40:22.799
<v Speaker 3>of all causes death, meaning usually that is another way

0:40:22.840 --> 0:40:25.120
<v Speaker 3>of saying a lot more of them died of cancer

0:40:25.160 --> 0:40:29.000
<v Speaker 3>as well. So you know, we talked some other time

0:40:29.040 --> 0:40:32.480
<v Speaker 3>about why that was. But that's why having access to

0:40:32.520 --> 0:40:35.960
<v Speaker 3>the underlying data is really important, so that other scientists

0:40:36.600 --> 0:40:38.960
<v Speaker 3>can go back and have a look themselves and do

0:40:39.000 --> 0:40:41.440
<v Speaker 3>their own analysis and see if they agree with what

0:40:41.480 --> 0:40:42.239
<v Speaker 3>you came up with.

0:40:43.239 --> 0:40:46.120
<v Speaker 2>Yeah, yeah, well that makes Yeah.

0:40:46.480 --> 0:40:49.720
<v Speaker 1>I wish we could get that kind of second review

0:40:49.880 --> 0:40:51.840
<v Speaker 1>on a lot of research.

0:40:53.160 --> 0:40:58.160
<v Speaker 2>And being dependent on trusting.

0:40:57.719 --> 0:41:02.920
<v Speaker 1>People who have a ender, who have a financial incentive

0:41:02.960 --> 0:41:04.360
<v Speaker 1>to produce certain outcomes.

0:41:04.360 --> 0:41:07.279
<v Speaker 2>It's not like it doesn't work, just doesn't work.

0:41:07.320 --> 0:41:09.200
<v Speaker 1>I don't know if that's going to go away anytime,

0:41:09.239 --> 0:41:13.120
<v Speaker 1>because I know funding for research is not abundant and

0:41:13.520 --> 0:41:17.520
<v Speaker 1>institution's financial Academic institutions have got to stay afloat, so

0:41:18.160 --> 0:41:21.160
<v Speaker 1>they're never going to stop taking money but I don't

0:41:21.160 --> 0:41:23.280
<v Speaker 1>know what the solution is, so that other solution.

0:41:23.800 --> 0:41:27.600
<v Speaker 3>The solution is government money. It has to be fund

0:41:27.960 --> 0:41:30.600
<v Speaker 3>You have to have governments that are prepared to invest

0:41:30.680 --> 0:41:36.400
<v Speaker 3>in research and you know, truly independent money that doesn't

0:41:36.440 --> 0:41:39.960
<v Speaker 3>care about the outcome, that is prepared to pay, you know,

0:41:40.320 --> 0:41:45.160
<v Speaker 3>for agencies like the CSIRO for example, to exist. And

0:41:45.200 --> 0:41:48.160
<v Speaker 3>it always, you know, frustrates me every time I hear

0:41:48.200 --> 0:41:51.280
<v Speaker 3>that the CSIRO's funding is being cut yet again, because

0:41:51.320 --> 0:41:53.640
<v Speaker 3>what inevitably happens there is they have to go and

0:41:53.719 --> 0:41:56.800
<v Speaker 3>seek funding from the private sector. If they have two choices,

0:41:56.800 --> 0:41:59.239
<v Speaker 3>they either start firing people or they get funding from

0:41:59.280 --> 0:42:01.400
<v Speaker 3>the private sector. And the private sector is only going

0:42:01.400 --> 0:42:03.080
<v Speaker 3>to give them money if they produce the results they

0:42:03.120 --> 0:42:03.640
<v Speaker 3>want to see.

0:42:04.280 --> 0:42:09.239
<v Speaker 1>Hmmm, yeah, one hundred uh. The article is called the

0:42:09.239 --> 0:42:13.520
<v Speaker 1>Statin Delusion. His name is David Brian Kevin Patrick Gillespie.

0:42:13.800 --> 0:42:14.839
<v Speaker 1>It's on substack.

0:42:15.600 --> 0:42:15.839
<v Speaker 2>Yeah.

0:42:15.880 --> 0:42:17.920
<v Speaker 3>You can also get to it from Facebook or just

0:42:17.960 --> 0:42:20.200
<v Speaker 3>from my website. Just go to David Gillespie dot org

0:42:21.080 --> 0:42:23.600
<v Speaker 3>and you can get to it from there too. One

0:42:23.600 --> 0:42:25.600
<v Speaker 3>thing I want to say about this article, and I

0:42:25.719 --> 0:42:28.000
<v Speaker 3>mentioned it at the top, and just just to stop

0:42:28.040 --> 0:42:32.440
<v Speaker 3>you and I being sued Craig is. This is not

0:42:32.560 --> 0:42:36.520
<v Speaker 3>medical advice. I am a lawyer. Craig is whatever he is,

0:42:36.719 --> 0:42:41.800
<v Speaker 3>but he's not a doctor and this is not medical advice.

0:42:42.680 --> 0:42:47.000
<v Speaker 3>Before you do anything, assuming you want to, about taking

0:42:47.040 --> 0:42:50.080
<v Speaker 3>statins or not taking statins, you have a conversation with

0:42:50.120 --> 0:42:52.640
<v Speaker 3>your doctor and ask them about this.

0:42:54.239 --> 0:42:58.000
<v Speaker 2>Spoken authorized by David Gillespie, lawyer. Lawyer.

0:42:58.680 --> 0:43:00.960
<v Speaker 1>Yeah, and just for the record, but I disagree with

0:43:01.200 --> 0:43:02.239
<v Speaker 1>everything he said.

0:43:03.840 --> 0:43:05.120
<v Speaker 2>Just fucking with you, mate.

0:43:05.160 --> 0:43:07.720
<v Speaker 1>We'll say goodbye affair as always, but for the minute,

0:43:08.080 --> 0:43:10.320
<v Speaker 1>thank you again and happy New Year Champ.

0:43:10.760 --> 0:43:11.960
<v Speaker 3>Yeah, having new you to you too.