1 00:00:00,360 --> 00:00:02,400 Speaker 1: I'll get a team. Welcome to another installing the show. 2 00:00:02,440 --> 00:00:06,320 Speaker 2: It's Jumbo, it's Tiff, It's Galspo, high bloody Glesspo. 3 00:00:06,880 --> 00:00:10,040 Speaker 1: On the same time. Hi mate, Sorry, how about you 4 00:00:10,160 --> 00:00:10,920 Speaker 1: same time again? 5 00:00:11,160 --> 00:00:13,200 Speaker 3: Oh I'm good. I'm glad to be doing it at 6 00:00:13,200 --> 00:00:14,000 Speaker 3: a reasonable time. 7 00:00:14,680 --> 00:00:17,680 Speaker 2: Yeah, well it's probably a little bit more suitable for you. 8 00:00:17,800 --> 00:00:20,319 Speaker 2: It's not middle of the afternoon. TIF, how are you. 9 00:00:20,480 --> 00:00:22,160 Speaker 4: I'm fabulous, Thanks for asking. 10 00:00:22,840 --> 00:00:28,680 Speaker 1: Yeah, no, we care, David and I care. Ie. No, 11 00:00:29,000 --> 00:00:29,680 Speaker 1: there's a lot of love. 12 00:00:29,800 --> 00:00:33,000 Speaker 2: We were talking before we went live about to how 13 00:00:33,040 --> 00:00:35,720 Speaker 2: two of us need makeup to look any good and 14 00:00:35,760 --> 00:00:37,320 Speaker 2: you're not one of them, so that's flattering. 15 00:00:37,920 --> 00:00:40,840 Speaker 4: It's already wear makeup arts just a little week will 16 00:00:40,920 --> 00:00:41,640 Speaker 4: be the miscura. 17 00:00:42,520 --> 00:00:42,920 Speaker 1: Yeah. 18 00:00:43,159 --> 00:00:45,559 Speaker 2: Yeah, I've got this very annoying thing going on at 19 00:00:45,560 --> 00:00:48,199 Speaker 2: the moment, which Gillispo just told me to try some garlic. 20 00:00:48,280 --> 00:00:50,879 Speaker 2: So I have this blocked ear that it just I 21 00:00:50,880 --> 00:00:53,800 Speaker 2: don't know. It's not water, it's not wax. It's just 22 00:00:53,960 --> 00:00:56,400 Speaker 2: like every now and then my ear just blocks like 23 00:00:56,480 --> 00:00:58,200 Speaker 2: this air bubble or something. 24 00:00:58,360 --> 00:01:01,280 Speaker 1: And it's happening right down right now. So if I 25 00:01:01,360 --> 00:01:04,080 Speaker 1: look down like I'm doing now'll probably take me off 26 00:01:04,120 --> 00:01:04,479 Speaker 1: the mic. 27 00:01:04,920 --> 00:01:07,319 Speaker 4: If you'd just take Mike with you, that'll be fine. 28 00:01:07,400 --> 00:01:08,800 Speaker 1: I could just take my mic with me. 29 00:01:09,200 --> 00:01:15,240 Speaker 2: Yep, and David, we're talking tonight about paracetamol, which has 30 00:01:15,280 --> 00:01:18,560 Speaker 2: a particular I don't know what would we call it 31 00:01:19,280 --> 00:01:22,000 Speaker 2: side effect or panadole as we call it in Australia, 32 00:01:22,040 --> 00:01:25,720 Speaker 2: or panadine or pana max. I think like there's a 33 00:01:25,800 --> 00:01:29,680 Speaker 2: million names for it, but it's all the same thing, paracetamol, 34 00:01:29,720 --> 00:01:33,520 Speaker 2: and it has an interesting would we call it side effect? 35 00:01:33,880 --> 00:01:35,039 Speaker 1: What would we call it? 36 00:01:35,200 --> 00:01:35,480 Speaker 2: Yeah? 37 00:01:35,959 --> 00:01:38,679 Speaker 3: I mean it's definitely wasn't intended, so I guess the 38 00:01:38,720 --> 00:01:42,360 Speaker 3: side effect. But you know, there's some really interesting things 39 00:01:42,400 --> 00:01:47,080 Speaker 3: about this drug that range from that to just some 40 00:01:47,120 --> 00:01:48,880 Speaker 3: of the things that we think we know about it 41 00:01:48,920 --> 00:01:52,520 Speaker 3: that probably aren't true too, like the fact that it's 42 00:01:52,520 --> 00:01:55,720 Speaker 3: a good pain killer. So we're going to dig into 43 00:01:55,760 --> 00:01:56,120 Speaker 3: that a bit. 44 00:01:56,640 --> 00:01:59,120 Speaker 1: We are a little bit. If you take panadole, do 45 00:01:59,200 --> 00:02:00,640 Speaker 1: you take any hankillers? 46 00:02:00,960 --> 00:02:03,080 Speaker 4: I did the other day, but very very rarely. 47 00:02:03,720 --> 00:02:05,520 Speaker 1: Yeah, me too. I'm not a big fan. 48 00:02:06,120 --> 00:02:08,440 Speaker 2: I don't like panadine fort because they make you not 49 00:02:08,560 --> 00:02:15,560 Speaker 2: poo for about a week. Canadine thoughts no good. If 50 00:02:15,600 --> 00:02:18,520 Speaker 2: you ever want to clog yourself up forever, Chuck a 51 00:02:18,520 --> 00:02:21,399 Speaker 2: few of those down your gob take away your headache, 52 00:02:21,440 --> 00:02:23,040 Speaker 2: and I'll take away your pooing power. 53 00:02:23,240 --> 00:02:24,799 Speaker 4: I don't want to do that, because I just bought 54 00:02:24,800 --> 00:02:27,000 Speaker 4: a squatty potty and that's quite a novelty in this 55 00:02:27,080 --> 00:02:27,760 Speaker 4: house right there. 56 00:02:30,000 --> 00:02:32,639 Speaker 2: How good are they when you change the old angle 57 00:02:32,680 --> 00:02:33,280 Speaker 2: of the dangle? 58 00:02:33,320 --> 00:02:35,799 Speaker 1: Then hey, when you suck. 59 00:02:35,639 --> 00:02:38,320 Speaker 2: Around with the biomechanics, if you're hipped and your coal 60 00:02:38,440 --> 00:02:41,600 Speaker 2: and shit, does it make a difference? 61 00:02:41,960 --> 00:02:42,919 Speaker 4: Yeah, I love it. 62 00:02:43,160 --> 00:02:43,600 Speaker 5: I love it. 63 00:02:44,280 --> 00:02:45,959 Speaker 4: Someone use my tool the other day and then later 64 00:02:46,040 --> 00:02:50,480 Speaker 4: on they go, plastic thing in your toilet. 65 00:02:51,280 --> 00:02:54,560 Speaker 2: That's a squatty potty, bro, That's that's going to revolutionize 66 00:02:54,560 --> 00:02:55,000 Speaker 2: your life. 67 00:02:55,840 --> 00:02:56,200 Speaker 3: Build them. 68 00:02:56,240 --> 00:02:59,359 Speaker 1: They weren't in doesn't. I have no idea what you're 69 00:02:59,400 --> 00:02:59,959 Speaker 1: talking about. 70 00:03:00,120 --> 00:03:02,359 Speaker 2: So a squatty potty is a thing that wraps around that. 71 00:03:02,560 --> 00:03:04,680 Speaker 2: We'll get to the topic at hand in a moment. 72 00:03:05,760 --> 00:03:08,440 Speaker 2: Fucking hell, we had this big preamble about what we're 73 00:03:08,440 --> 00:03:10,760 Speaker 2: going to talk about. We're doing none of it. It's 74 00:03:10,880 --> 00:03:14,799 Speaker 2: like it's almost like a little plastic wrap around footstool 75 00:03:14,880 --> 00:03:18,120 Speaker 2: for your bog and we sit down and you put 76 00:03:18,120 --> 00:03:20,919 Speaker 2: your feet on it, and I think there's like one 77 00:03:21,080 --> 00:03:23,959 Speaker 2: fifty meal which is six inch, two hundred mil which 78 00:03:24,000 --> 00:03:27,800 Speaker 2: is eight inch, and it elevates your feet so your 79 00:03:27,880 --> 00:03:31,280 Speaker 2: knees come up, so it's almost like you're squatting. So 80 00:03:31,360 --> 00:03:34,320 Speaker 2: it only puts your body, your pelvis, your spine, your 81 00:03:34,400 --> 00:03:39,160 Speaker 2: legs in a position where it's more efficient. 82 00:03:39,240 --> 00:03:43,680 Speaker 1: Let's just say that, why why would you want to 83 00:03:43,680 --> 00:03:47,480 Speaker 1: do that? Because a lot of people get constipated. 84 00:03:47,840 --> 00:03:50,000 Speaker 3: Well, then you need to stop eating fiber. We've talked 85 00:03:50,000 --> 00:03:51,880 Speaker 3: about this before, Craig, stop eating fiber. 86 00:03:51,880 --> 00:03:52,480 Speaker 1: They'll be fine. 87 00:03:53,440 --> 00:03:58,040 Speaker 2: Oh dear, I don't know that you and the Australia 88 00:03:58,080 --> 00:04:00,280 Speaker 2: that you and the AMAC eye on that. 89 00:04:00,880 --> 00:04:02,400 Speaker 3: No, but one of us is right. 90 00:04:05,640 --> 00:04:09,000 Speaker 2: Anyway, squatty potty, if you're unless giving up other than 91 00:04:09,040 --> 00:04:11,040 Speaker 2: giving up fiber, everyone, if you want to try this, 92 00:04:11,080 --> 00:04:14,680 Speaker 2: squatty potty, I've done I think two episodes on twoing 93 00:04:14,720 --> 00:04:16,839 Speaker 2: over the years, so you can look up those now. 94 00:04:17,640 --> 00:04:20,240 Speaker 2: Before we do a deep dive, we've got we're going 95 00:04:20,320 --> 00:04:23,680 Speaker 2: to talk about paracetamol and one of the interesting effects 96 00:04:23,680 --> 00:04:26,880 Speaker 2: of it, I guess. But there's also something interesting I'm 97 00:04:26,880 --> 00:04:30,240 Speaker 2: not going to say too much other than there's some 98 00:04:30,440 --> 00:04:35,160 Speaker 2: audio that TIFF's going to edit in with the magic 99 00:04:35,240 --> 00:04:37,240 Speaker 2: of her fingers. I don't know how she's going to 100 00:04:37,279 --> 00:04:40,000 Speaker 2: do that. Neither is David or David definitely does I don't. 101 00:04:41,240 --> 00:04:42,520 Speaker 2: So let's have a listen to that. 102 00:04:44,920 --> 00:04:47,400 Speaker 5: So we've all got that bottle in our medicine cabinet, right, 103 00:04:47,960 --> 00:04:53,320 Speaker 5: you know, the one we reach for without even thinking headache, fever, general, 104 00:04:53,360 --> 00:04:54,039 Speaker 5: eggs and pans. 105 00:04:54,120 --> 00:04:58,360 Speaker 6: Yeah, that little white pill, lasitam minifin, paracetamol tail and 106 00:04:58,440 --> 00:05:00,400 Speaker 6: all panell Well. 107 00:05:02,000 --> 00:05:05,160 Speaker 5: So many names, right, same stuff though, just depends on well, 108 00:05:05,200 --> 00:05:07,520 Speaker 5: I guess where you are in the world. But it's 109 00:05:07,640 --> 00:05:10,960 Speaker 5: so common, so familiar. But is there more to this 110 00:05:11,640 --> 00:05:14,200 Speaker 5: simple pain reliever than meets the eye? 111 00:05:14,400 --> 00:05:17,200 Speaker 6: That's what we're diving into today. And you know, even 112 00:05:17,320 --> 00:05:20,680 Speaker 6: just that difference in meming acetamnafin here in the US 113 00:05:20,760 --> 00:05:24,479 Speaker 6: and paracetamol everywhere else, it's kind of fascinating, same chemical, 114 00:05:24,560 --> 00:05:27,719 Speaker 6: different name. It hints that I don't know a story 115 00:05:27,760 --> 00:05:29,200 Speaker 6: behind this everyday. 116 00:05:28,800 --> 00:05:31,279 Speaker 5: Thing, definitely, And we tend to think of it as 117 00:05:31,360 --> 00:05:34,000 Speaker 5: the safer option, right, I mean compared to asprin or 118 00:05:34,040 --> 00:05:36,760 Speaker 5: iberprofit like we've been told for years and in always 119 00:05:36,760 --> 00:05:40,159 Speaker 5: it is. But there's always that if use correctly caveat. 120 00:05:39,960 --> 00:05:41,920 Speaker 6: Exactly, and I think that's where we should start a 121 00:05:42,000 --> 00:05:44,919 Speaker 6: seedamnifin might be over the counter and in everyone's home, 122 00:05:45,160 --> 00:05:47,800 Speaker 6: but it actually has what's called a narrow therapeutic window. 123 00:05:47,960 --> 00:05:50,680 Speaker 1: Neuro therapeutic window. Huh im, Sure I've heard that one before. 124 00:05:51,279 --> 00:05:55,040 Speaker 2: All right, there we go. So what was that, David? 125 00:05:55,080 --> 00:06:03,920 Speaker 2: Those two very smooth professional people talking about paracetamol? Who 126 00:06:03,960 --> 00:06:06,159 Speaker 2: were they and what were we just listening to? 127 00:06:07,880 --> 00:06:15,479 Speaker 3: They were your replacements. So that's the latest innovation in AI, 128 00:06:15,680 --> 00:06:20,120 Speaker 3: which is that you can take any document, including this article, 129 00:06:20,160 --> 00:06:23,000 Speaker 3: which is the one I use to create that, and 130 00:06:23,160 --> 00:06:25,839 Speaker 3: shove it into an AI. In this case, it's the 131 00:06:25,880 --> 00:06:33,400 Speaker 3: Google Gemini AI, and it will automatically create a podcast 132 00:06:33,480 --> 00:06:37,400 Speaker 3: type conversation between two people about the contents of the article. 133 00:06:37,960 --> 00:06:41,520 Speaker 3: So the reason I included it when I posted this 134 00:06:41,680 --> 00:06:45,160 Speaker 3: article is some people just prefer to get their information 135 00:06:45,320 --> 00:06:48,160 Speaker 3: that way. Some people don't like reading a two and 136 00:06:48,200 --> 00:06:51,040 Speaker 3: a half thousand word article, and I suspect I may 137 00:06:51,040 --> 00:06:54,760 Speaker 3: be talking to one of them, and an easier way 138 00:06:54,880 --> 00:06:57,960 Speaker 3: for them to get that information is just to hear 139 00:06:58,040 --> 00:07:00,920 Speaker 3: people do what we're doing, which is chat about it 140 00:07:01,720 --> 00:07:04,560 Speaker 3: and I found it amazing because when you listen to 141 00:07:04,600 --> 00:07:06,520 Speaker 3: that all the way through, which people can do by 142 00:07:06,600 --> 00:07:10,440 Speaker 3: just going to the article on my substack and it's 143 00:07:10,480 --> 00:07:13,200 Speaker 3: there as part of it is when you listen to 144 00:07:13,240 --> 00:07:15,640 Speaker 3: it all the way through, it doesn't miss anything. It 145 00:07:15,680 --> 00:07:18,760 Speaker 3: picks up everything that we're about to talk about. It 146 00:07:18,800 --> 00:07:21,720 Speaker 3: does it in a really engaging way in a conversation 147 00:07:21,840 --> 00:07:26,680 Speaker 3: between two people. Admittedly annoying American accent to people, but 148 00:07:28,560 --> 00:07:31,240 Speaker 3: it does a great conversation, does a great job of 149 00:07:31,360 --> 00:07:33,720 Speaker 3: talking about the article. And it'll be interesting to hear 150 00:07:33,840 --> 00:07:37,640 Speaker 3: what your listeners think. Do you and I do a 151 00:07:37,640 --> 00:07:41,800 Speaker 3: better job talking about this article or do they because 152 00:07:42,360 --> 00:07:44,200 Speaker 3: I actually found it really quite engaging. 153 00:07:45,200 --> 00:07:47,560 Speaker 2: Well, if you and I do a better job, then 154 00:07:48,080 --> 00:07:50,680 Speaker 2: Google needs have a good look at themselves, because definitely 155 00:07:51,000 --> 00:07:52,280 Speaker 2: we are not the high watermark. 156 00:07:52,560 --> 00:07:54,840 Speaker 1: But so are you saying that. 157 00:07:56,760 --> 00:08:00,840 Speaker 2: You just put this written article into a program and 158 00:08:01,880 --> 00:08:03,760 Speaker 2: with what instruction? 159 00:08:03,960 --> 00:08:05,720 Speaker 1: So just turn this into a podcast? 160 00:08:06,280 --> 00:08:08,000 Speaker 3: No, I just asked it to give me an audio 161 00:08:08,000 --> 00:08:09,600 Speaker 3: summary and that's what it produced. 162 00:08:10,040 --> 00:08:14,040 Speaker 2: Wow, that is because when I mean, I didn't know that, 163 00:08:14,160 --> 00:08:16,080 Speaker 2: Like you said, I've been busy all done, and you said, 164 00:08:16,160 --> 00:08:18,360 Speaker 2: have you listened to the audio and I went no, 165 00:08:18,600 --> 00:08:21,640 Speaker 2: and then I just listened to ninety seconds. I went, well, 166 00:08:21,680 --> 00:08:24,160 Speaker 2: this is interesting and they are good. Who are they? 167 00:08:25,160 --> 00:08:30,120 Speaker 2: And you went essentially, they're robots. So this could be 168 00:08:30,160 --> 00:08:31,800 Speaker 2: the home straight for the U project. 169 00:08:31,880 --> 00:08:36,319 Speaker 1: Let's be honest, Well, the next step might be the end. 170 00:08:36,760 --> 00:08:39,600 Speaker 3: The next step, as I mentioned to you off air, 171 00:08:39,880 --> 00:08:42,040 Speaker 3: is at the moment you don't get a choice about 172 00:08:42,040 --> 00:08:46,240 Speaker 3: the voices it uses. They're just that bloken and that 173 00:08:46,280 --> 00:08:49,880 Speaker 3: woman who are American. But you could easily imagine the 174 00:08:49,880 --> 00:08:51,600 Speaker 3: next step there is going to be that you could 175 00:08:51,640 --> 00:08:54,240 Speaker 3: supply a voice, so you could say, speak a certain 176 00:08:54,280 --> 00:08:58,560 Speaker 3: sentence in and then it could create the same thing 177 00:08:58,600 --> 00:08:59,760 Speaker 3: but using your voice. 178 00:09:00,840 --> 00:09:03,439 Speaker 2: And then the Tiff and I like, we could plug 179 00:09:03,440 --> 00:09:06,160 Speaker 2: in our voices and I could sit in the bean 180 00:09:06,240 --> 00:09:09,560 Speaker 2: bag and watch bloody Netflix while I'm doing a podcast. 181 00:09:10,000 --> 00:09:10,360 Speaker 1: That's right. 182 00:09:10,400 --> 00:09:13,560 Speaker 3: I could send you an article you could feed it 183 00:09:13,600 --> 00:09:15,280 Speaker 3: in and that'd be done. 184 00:09:16,000 --> 00:09:16,559 Speaker 1: Yeah. 185 00:09:16,760 --> 00:09:20,080 Speaker 2: Yeah, I wonder if they could incorporate swearing, just to 186 00:09:20,120 --> 00:09:22,319 Speaker 2: make it, you know, believable. 187 00:09:24,480 --> 00:09:25,440 Speaker 1: Sure they could. 188 00:09:26,440 --> 00:09:30,360 Speaker 2: Yeah, all right, so give us the skinny. Hey, I'm 189 00:09:30,960 --> 00:09:32,920 Speaker 2: let me just tell you. The article is called the 190 00:09:32,920 --> 00:09:36,680 Speaker 2: empty Pill Paracetamol Surprising side effect. 191 00:09:36,880 --> 00:09:39,680 Speaker 1: And for some of you who are going I think 192 00:09:39,720 --> 00:09:40,800 Speaker 1: I've heard something. 193 00:09:40,480 --> 00:09:43,760 Speaker 2: About this, well done you. We did have a brief 194 00:09:43,840 --> 00:09:47,000 Speaker 2: chat about it, but I reckon it was probably a 195 00:09:47,040 --> 00:09:51,480 Speaker 2: good three years ago, and I think we have a 196 00:09:51,600 --> 00:09:56,400 Speaker 2: very bigger and different audience to them. But for the 197 00:09:56,440 --> 00:09:58,840 Speaker 2: few of you who have heard some of this before, 198 00:09:59,040 --> 00:10:01,160 Speaker 2: just call it revision off you go. 199 00:10:01,200 --> 00:10:03,880 Speaker 3: Champion, well and just you know, a check that we 200 00:10:04,040 --> 00:10:07,480 Speaker 3: still get it right. So I think parasito wal is 201 00:10:07,520 --> 00:10:15,440 Speaker 3: a really interesting painkiller, mostly because it doesn't really work. It's, 202 00:10:16,040 --> 00:10:18,920 Speaker 3: you know, which is surprising given that you know, twenty 203 00:10:18,960 --> 00:10:24,280 Speaker 3: five billion pills are downed by Americans every year. You know. 204 00:10:24,880 --> 00:10:27,800 Speaker 3: In Australia, I think it's something like more than sixty 205 00:10:27,800 --> 00:10:30,520 Speaker 3: percent of us by it at least once a month. 206 00:10:31,720 --> 00:10:38,679 Speaker 3: It's it's one of the world's most heavily consumed medicines 207 00:10:39,120 --> 00:10:45,320 Speaker 3: and consumed for just about anything pain or fever related. 208 00:10:45,920 --> 00:10:48,079 Speaker 3: Now we're not talking about the anti fever of the 209 00:10:48,080 --> 00:10:51,000 Speaker 3: anti inflammatory effects of parasitamal today. What we're talking about 210 00:10:51,120 --> 00:10:55,480 Speaker 3: is the painkilling aspects, and quite a few large recent 211 00:10:55,559 --> 00:10:59,800 Speaker 3: studies have suggested that it really doesn't do much and 212 00:10:59,840 --> 00:11:01,720 Speaker 3: it's the kind of thing that can be studied quite 213 00:11:01,720 --> 00:11:04,439 Speaker 3: well because it's easy to give someone a placebo and 214 00:11:04,600 --> 00:11:08,880 Speaker 3: give them some paracetamol, and so, unlike many of the 215 00:11:08,880 --> 00:11:11,360 Speaker 3: things we talk about where you know the thing you're 216 00:11:11,360 --> 00:11:14,400 Speaker 3: trying to prove might kill someone if you do it, 217 00:11:14,440 --> 00:11:18,400 Speaker 3: this is easy to study. So and a lot of 218 00:11:18,400 --> 00:11:20,199 Speaker 3: those studies and then the most recent one is one 219 00:11:20,200 --> 00:11:22,360 Speaker 3: that came out on back pain just a week or 220 00:11:22,440 --> 00:11:27,160 Speaker 3: so ago, massive study really well conducted multiple control arms 221 00:11:27,160 --> 00:11:32,199 Speaker 3: where people are being given placebos and paracetamol, not just 222 00:11:34,240 --> 00:11:37,320 Speaker 3: that they're testing lots of things for back pain. I mean, 223 00:11:37,720 --> 00:11:39,480 Speaker 3: we could talk about this another day, but what they 224 00:11:39,520 --> 00:11:41,720 Speaker 3: found in that study is essentially there's not much that 225 00:11:41,800 --> 00:11:45,280 Speaker 3: works for back pain. And I'm talking about low back pain. 226 00:11:45,880 --> 00:11:48,720 Speaker 3: A lot of people have low back pain. Almost nothing works, 227 00:11:49,320 --> 00:11:56,880 Speaker 3: including paracetamol. It turns out, so and essentially what a 228 00:11:56,880 --> 00:11:59,360 Speaker 3: lot of the studies are arriving at with paracetamol is 229 00:12:00,400 --> 00:12:03,800 Speaker 3: any effect that is perceived to have occurred is usually 230 00:12:03,920 --> 00:12:07,520 Speaker 3: just a placeivedle effect where the person feels better because 231 00:12:07,520 --> 00:12:10,000 Speaker 3: they believe they've taken something for it. And that's not 232 00:12:10,040 --> 00:12:13,240 Speaker 3: to discount that that is a real effect, or as 233 00:12:13,240 --> 00:12:18,280 Speaker 3: they often say, in the studies that the effect is 234 00:12:18,400 --> 00:12:24,440 Speaker 3: statistically significant yet clinically minimal, meaning a statistician might find 235 00:12:24,480 --> 00:12:27,080 Speaker 3: it interesting, but the person suffering the pain probably doesn't. 236 00:12:27,840 --> 00:12:32,160 Speaker 3: There are some kinds of pain where it can be effective, 237 00:12:33,600 --> 00:12:36,640 Speaker 3: so it's been found to be modestly helpful for some 238 00:12:36,760 --> 00:12:42,520 Speaker 3: types of headache and also some sorts of physical pain 239 00:12:43,040 --> 00:12:47,680 Speaker 3: caused by over exercise and things like that. But it's 240 00:12:47,760 --> 00:12:52,640 Speaker 3: overall not a great pain killer. But it doesn't has 241 00:12:52,679 --> 00:12:56,280 Speaker 3: a stop just taking it by the truckload, and it's 242 00:12:56,400 --> 00:13:00,559 Speaker 3: easily the most sold pain killer in the Western world. 243 00:13:01,200 --> 00:13:03,600 Speaker 3: But its history of getting to there is quite interesting too. 244 00:13:04,200 --> 00:13:07,520 Speaker 3: It really only got there from the start of this 245 00:13:07,640 --> 00:13:12,920 Speaker 3: century onwards because aspirin had a bit of a problem. 246 00:13:12,960 --> 00:13:17,200 Speaker 3: So last century, the big, the big painkiller was aspirin. 247 00:13:18,320 --> 00:13:20,240 Speaker 3: You know, that was what everyone talk that was what 248 00:13:20,320 --> 00:13:26,840 Speaker 3: everyone trusted. And it was because some concerns were raised 249 00:13:26,960 --> 00:13:31,720 Speaker 3: about paracetamol being used in children who were suffering from 250 00:13:31,760 --> 00:13:34,960 Speaker 3: certain viral conditions that they could get a condition called 251 00:13:35,320 --> 00:13:39,920 Speaker 3: raise ariy es, which is a brain swelling thing, quite 252 00:13:40,040 --> 00:13:45,880 Speaker 3: dangerous and nasty. And when that started to become clear, 253 00:13:46,960 --> 00:13:50,800 Speaker 3: a bit of a panic started about using as sorry 254 00:13:50,840 --> 00:13:54,880 Speaker 3: not paracetamol. Doing aspirin did that, and how a bit 255 00:13:54,880 --> 00:14:00,480 Speaker 3: of a panic started about using aspirin, and paracetamol jumped. 256 00:14:00,640 --> 00:14:03,480 Speaker 3: The makers of paracenamole jumped on that market opportunity and 257 00:14:04,240 --> 00:14:08,160 Speaker 3: have really come to own the market since. So you 258 00:14:08,240 --> 00:14:12,640 Speaker 3: get the picture. Everybody takes it all the time. It's massive, 259 00:14:12,920 --> 00:14:17,800 Speaker 3: huge market, not particularly effective, but that doesn't seem to 260 00:14:17,880 --> 00:14:21,240 Speaker 3: bother at anyone. It's what we all take. By the way, 261 00:14:21,320 --> 00:14:27,080 Speaker 3: people are wondering what they should be taking. Thes NSAIDs 262 00:14:27,600 --> 00:14:32,080 Speaker 3: are probably a better choice, that's overprofen, but they have 263 00:14:32,160 --> 00:14:36,400 Speaker 3: their own concerns. You've got to watch out for overdosing there. Overdosing, 264 00:14:36,440 --> 00:14:40,120 Speaker 3: by the way, is a real problem for paracetamol. It 265 00:14:40,240 --> 00:14:44,120 Speaker 3: is the primary cause of acute liver failure in both Britain, 266 00:14:44,240 --> 00:14:48,880 Speaker 3: Australia and the United States every year. So overdosing paracetamol, 267 00:14:49,040 --> 00:14:52,440 Speaker 3: either intentionally or accidentally, and people might say, what about it? 268 00:14:52,480 --> 00:14:55,200 Speaker 3: Why would anyone be doing it intentionally? Because it's a 269 00:14:55,240 --> 00:15:03,600 Speaker 3: preferred form of suicide in some places, and so although 270 00:15:03,640 --> 00:15:06,440 Speaker 3: it's a bit hard to disentangle whether it was intentional 271 00:15:06,560 --> 00:15:09,920 Speaker 3: or not when people are overdosing, but one hundred. There 272 00:15:09,920 --> 00:15:12,280 Speaker 3: are one hundred thousand overdoses a year in the United 273 00:15:12,280 --> 00:15:16,640 Speaker 3: States from paracetamol, and that's because it's got a fairly 274 00:15:16,680 --> 00:15:22,000 Speaker 3: thin line between effective painkilling capability and just a bit 275 00:15:22,040 --> 00:15:24,640 Speaker 3: too much, because it and just a bit too much 276 00:15:24,680 --> 00:15:28,560 Speaker 3: can wreckt the liver, which can result in very dangerous 277 00:15:28,600 --> 00:15:34,760 Speaker 3: acute overdoses, which can often be lethal. So we've got 278 00:15:34,800 --> 00:15:39,960 Speaker 3: this thing which is potentially quite dangerous, is taken by billions, 279 00:15:40,440 --> 00:15:43,400 Speaker 3: well certainly hundreds of millions of US, and taken in 280 00:15:43,520 --> 00:15:49,400 Speaker 3: quantities of billions, and yet it doesn't really isn't all 281 00:15:49,440 --> 00:15:53,280 Speaker 3: that effective against the things that we think it is. 282 00:15:53,720 --> 00:15:56,600 Speaker 3: But the interesting bit I found was that there were 283 00:15:56,640 --> 00:15:59,120 Speaker 3: some studies done in the last five or six years 284 00:15:59,640 --> 00:16:03,600 Speaker 3: that have talked that have looked at does parasnamol have 285 00:16:03,680 --> 00:16:08,760 Speaker 3: an effect other than on pain, and in fact, does 286 00:16:08,800 --> 00:16:12,400 Speaker 3: it affect what I would call social pain? So that 287 00:16:12,640 --> 00:16:17,680 Speaker 3: is whether you feel socially left out of a group, 288 00:16:17,760 --> 00:16:21,000 Speaker 3: So if there's a group activity going on, and whether 289 00:16:21,040 --> 00:16:23,400 Speaker 3: you feel social harm from So, say you're in a 290 00:16:23,400 --> 00:16:26,520 Speaker 3: group with three or four people and everyone else in 291 00:16:26,520 --> 00:16:28,680 Speaker 3: the group is talking to each other and ignoring you, 292 00:16:29,960 --> 00:16:34,320 Speaker 3: do you feel upset by that do you feel you know, 293 00:16:35,280 --> 00:16:39,480 Speaker 3: harm from that, And there's really some quite convincing studies 294 00:16:40,120 --> 00:16:45,000 Speaker 3: that show yes. And these are placebo controlled studies once again, 295 00:16:45,040 --> 00:16:49,640 Speaker 3: where they are giving people parasnamol and they're giving others percebo, 296 00:16:49,760 --> 00:16:52,840 Speaker 3: and they're measuring the degree to which people say they 297 00:16:52,880 --> 00:16:56,720 Speaker 3: feel disaffected by certain behaviors that they're putting through testing. 298 00:16:58,760 --> 00:17:01,040 Speaker 3: They're finding yes, in fact, they do the people who 299 00:17:01,080 --> 00:17:07,520 Speaker 3: are taking the paracetamol feel the pain less, They don't. 300 00:17:07,520 --> 00:17:14,680 Speaker 2: Care subjects of psychometric testing. That sounds like psychology. 301 00:17:14,280 --> 00:17:14,800 Speaker 1: It does. 302 00:17:15,160 --> 00:17:17,920 Speaker 3: But I, of course did then go and look at 303 00:17:18,040 --> 00:17:20,280 Speaker 3: the extended armor of that study that put them in 304 00:17:20,320 --> 00:17:27,359 Speaker 3: a functional MRI machine. Otherwise otherwise I would have discounted 305 00:17:27,400 --> 00:17:32,880 Speaker 3: it entirely. But yes, even when they jammed them into 306 00:17:32,880 --> 00:17:36,000 Speaker 3: an MRI machine and had them play a virtual game 307 00:17:36,040 --> 00:17:39,240 Speaker 3: that excluded them, they saw the bits of the brain 308 00:17:39,280 --> 00:17:43,480 Speaker 3: that are associated with social acceptance being affected in the 309 00:17:43,520 --> 00:17:46,200 Speaker 3: people that were on paracetamol. So what I was doing 310 00:17:46,320 --> 00:17:52,560 Speaker 3: was turning down their sensitivity to oxytocin induced acceptance. Meaning 311 00:17:52,920 --> 00:17:55,800 Speaker 3: when people left you out or mean to you, you 312 00:17:55,840 --> 00:17:58,399 Speaker 3: didn't feel it as much. You didn't care for women. 313 00:17:58,400 --> 00:18:02,439 Speaker 3: It meant they became males in essence, because males are 314 00:18:02,480 --> 00:18:06,080 Speaker 3: much less sensitive to oxytocin any way, and for males 315 00:18:06,080 --> 00:18:09,040 Speaker 3: it means they became psychopaths. Well, I may be exaggerating 316 00:18:09,080 --> 00:18:12,640 Speaker 3: a bit, but it's the same effect, which is that, 317 00:18:13,280 --> 00:18:17,760 Speaker 3: in essence, you lose empathy. So what it was doing 318 00:18:18,320 --> 00:18:22,160 Speaker 3: was affecting empathy. And to extend that study, a whole 319 00:18:22,200 --> 00:18:25,520 Speaker 3: different group of researchers said, does this work the other way? 320 00:18:26,119 --> 00:18:29,960 Speaker 3: Does it affect positive empathy? So we don't just have 321 00:18:30,080 --> 00:18:32,879 Speaker 3: negative empathy where we feel others pain or we feel 322 00:18:32,880 --> 00:18:35,720 Speaker 3: pain because of the way people treat us. We also 323 00:18:35,760 --> 00:18:39,240 Speaker 3: have positive empathy where something good happens for somebody and 324 00:18:39,280 --> 00:18:44,119 Speaker 3: we feel good too. Yes, and psychopaths listening won't know 325 00:18:44,119 --> 00:18:48,080 Speaker 3: what I'm talking about, but take it from me. Normal 326 00:18:48,160 --> 00:18:52,040 Speaker 3: humans feel that when good things happen to other people, 327 00:18:52,080 --> 00:18:53,240 Speaker 3: they feel good too. 328 00:18:54,359 --> 00:18:55,879 Speaker 1: Psychopaths, that's right. 329 00:18:56,400 --> 00:18:58,760 Speaker 3: I just need to you know, it's like having subtitles. 330 00:18:59,200 --> 00:19:01,639 Speaker 3: You need to stand that one in twenty of your 331 00:19:01,640 --> 00:19:04,040 Speaker 3: listeners are psychopaths and they have no idea what we're 332 00:19:04,040 --> 00:19:08,160 Speaker 3: talking about. So you got to pull. 333 00:19:08,000 --> 00:19:10,639 Speaker 2: Those people right now, going, fuck you, we are not 334 00:19:11,119 --> 00:19:14,880 Speaker 2: you're a psychopath now the people, the people who were saying, 335 00:19:14,920 --> 00:19:15,920 Speaker 2: I don't know what he's talking about. 336 00:19:15,960 --> 00:19:21,920 Speaker 3: Ah, the cycles. So anyway, so that experiment once again 337 00:19:22,520 --> 00:19:26,520 Speaker 3: quality can really high quality study. And they did the 338 00:19:26,560 --> 00:19:31,320 Speaker 3: same thing, gave some people paracetamoal, gave others pacebo to 339 00:19:31,359 --> 00:19:35,159 Speaker 3: see what happened, and once again tested it again with 340 00:19:35,240 --> 00:19:38,240 Speaker 3: functional MRI to make sure that they weren't just imagining 341 00:19:38,280 --> 00:19:42,760 Speaker 3: this stuff, and same thing was happening, same parts of 342 00:19:42,760 --> 00:19:46,960 Speaker 3: the brain non activating and coordinating with what people were 343 00:19:47,000 --> 00:19:50,359 Speaker 3: reporting about what they felt. So they were genuinely not 344 00:19:50,440 --> 00:19:53,560 Speaker 3: feeling as good about someone. They knew that something good 345 00:19:53,600 --> 00:19:55,040 Speaker 3: was happening, and they could see that something good was 346 00:19:55,080 --> 00:20:00,040 Speaker 3: happening for the other person, but they didn't care. So 347 00:20:00,119 --> 00:20:03,439 Speaker 3: that's interesting. What that tells us is that parasnomol has 348 00:20:03,480 --> 00:20:07,920 Speaker 3: an effect on the parts of the brain that are 349 00:20:07,960 --> 00:20:11,760 Speaker 3: involved in empathy, the exact same parts of the brain 350 00:20:12,080 --> 00:20:18,120 Speaker 3: that do not work in psychopaths. So what we are 351 00:20:18,440 --> 00:20:22,240 Speaker 3: saying here is that you've got a temporary empathy pill 352 00:20:22,400 --> 00:20:26,439 Speaker 3: or psychopath pill here is that when you take this 353 00:20:26,480 --> 00:20:30,920 Speaker 3: stuff that doesn't really work very well, what you're actually 354 00:20:30,960 --> 00:20:34,760 Speaker 3: doing is dulling down your empathy. You're turning yourself into 355 00:20:34,800 --> 00:20:38,640 Speaker 3: a psychopath. You become less caring, you call, you are 356 00:20:38,720 --> 00:20:42,160 Speaker 3: less concerned about the welfare of others for the time 357 00:20:42,200 --> 00:20:44,000 Speaker 3: that you were on the dose of this pill. The 358 00:20:44,040 --> 00:20:45,720 Speaker 3: other thing the studies found is that it was only 359 00:20:46,080 --> 00:20:48,920 Speaker 3: for the duration of the pill. So you know, if 360 00:20:48,960 --> 00:20:50,640 Speaker 3: it says on the pack this will last four hours, 361 00:20:50,640 --> 00:20:53,120 Speaker 3: then that's how long it lasts, so that we're back 362 00:20:53,160 --> 00:20:56,920 Speaker 3: to normal after four hours. But it was only while 363 00:20:56,960 --> 00:20:59,840 Speaker 3: you were taking it. So don't ask someone for a 364 00:21:00,160 --> 00:21:03,440 Speaker 3: favor or assistance or to care about you if they've 365 00:21:03,600 --> 00:21:07,000 Speaker 3: just taken a paracetamol. Is to take away from that, 366 00:21:07,480 --> 00:21:09,400 Speaker 3: because they're temporary psychopaths. 367 00:21:10,520 --> 00:21:11,560 Speaker 1: That's the name of the show. 368 00:21:11,640 --> 00:21:15,600 Speaker 2: What about the converse of that, where we have to 369 00:21:15,640 --> 00:21:18,960 Speaker 2: go and do something that might be really emotionally confronting 370 00:21:19,000 --> 00:21:23,720 Speaker 2: and psychologically confronting, something that's very difficult. 371 00:21:23,680 --> 00:21:24,680 Speaker 3: Might be a good idea. 372 00:21:25,040 --> 00:21:28,080 Speaker 2: I take a couple of pan and dole, do that 373 00:21:28,160 --> 00:21:31,359 Speaker 2: thing that's really emotionally confronting and difficult. 374 00:21:31,760 --> 00:21:32,639 Speaker 1: Yeah, if you're going to have. 375 00:21:34,400 --> 00:21:37,240 Speaker 2: Like that sounds like not the worst strategy, Like I 376 00:21:37,320 --> 00:21:41,879 Speaker 2: need to go and have these very difficult emotional conversations 377 00:21:41,960 --> 00:21:45,960 Speaker 2: or deal with this thing that's confronting for me. So 378 00:21:46,080 --> 00:21:49,480 Speaker 2: I'll just turn myself into a mild psychopath between now 379 00:21:49,480 --> 00:21:49,960 Speaker 2: and dinner. 380 00:21:50,840 --> 00:21:54,240 Speaker 3: Yeah, look, there's no reason why that wouldn't work. That 381 00:21:54,440 --> 00:21:58,560 Speaker 3: This science is pretty solid. It's it's been well verified. 382 00:21:58,600 --> 00:22:02,440 Speaker 3: The other interesting study that I came is one where 383 00:22:02,880 --> 00:22:08,440 Speaker 3: they noticed that there's been a definitive lack or decline 384 00:22:08,480 --> 00:22:11,280 Speaker 3: in empathy in college students in the United States. So 385 00:22:11,320 --> 00:22:14,840 Speaker 3: there's a study that's done every year where they get 386 00:22:14,960 --> 00:22:18,040 Speaker 3: the same age of child every year, so a first 387 00:22:18,119 --> 00:22:20,879 Speaker 3: year college student, and they've been doing it since the 388 00:22:20,920 --> 00:22:23,480 Speaker 3: nineteen seventies where they just go through every year and 389 00:22:23,520 --> 00:22:26,240 Speaker 3: they ask the same set of questions about how they 390 00:22:26,280 --> 00:22:28,440 Speaker 3: feel about other people and other things and all that 391 00:22:28,480 --> 00:22:32,159 Speaker 3: sort of thing, and they chart that as an empathy score, 392 00:22:32,240 --> 00:22:34,600 Speaker 3: if you like. And that empathy score has been pretty 393 00:22:34,680 --> 00:22:38,600 Speaker 3: much the same up until about the early two thousands 394 00:22:38,600 --> 00:22:41,600 Speaker 3: when it was started dropping like a stone. So empathy 395 00:22:41,640 --> 00:22:44,679 Speaker 3: is off about forty percent on that study since the 396 00:22:44,680 --> 00:22:48,399 Speaker 3: start of the century in the same age of college student. 397 00:22:48,840 --> 00:22:53,400 Speaker 3: And the study authors said, we don't know what's causing this. 398 00:22:53,400 --> 00:22:57,080 Speaker 3: This is weird, right, Why have empathy gone out the window? 399 00:22:57,960 --> 00:23:04,080 Speaker 3: And I don't know coincidence. The takeoff of paracetamol as 400 00:23:04,200 --> 00:23:08,320 Speaker 3: a mass drug used in the billions in the population 401 00:23:08,600 --> 00:23:14,040 Speaker 3: happened at about the same time that people throughout the 402 00:23:14,080 --> 00:23:18,920 Speaker 3: population have lost empathy. Yeah, you know, it's a big look. 403 00:23:18,960 --> 00:23:22,240 Speaker 3: Correlation is not causation, but it's not. I don't think 404 00:23:22,240 --> 00:23:25,120 Speaker 3: it's a long way to go there. We suddenly are 405 00:23:25,200 --> 00:23:28,720 Speaker 3: taking this thing in the bindins and it has a demonstrated, 406 00:23:28,960 --> 00:23:32,159 Speaker 3: proven effect on empathy. It's not a big reach to 407 00:23:32,240 --> 00:23:36,879 Speaker 3: say it's making the population in general less empathetic. So 408 00:23:37,040 --> 00:23:40,959 Speaker 3: if you think people are ruder and careless now than 409 00:23:41,000 --> 00:23:43,840 Speaker 3: in the olden days, maybe it isn't just kids these days. 410 00:23:44,400 --> 00:23:48,840 Speaker 3: Maybe it's just that they're taking a pill that destroys empathy. 411 00:23:50,240 --> 00:23:53,600 Speaker 2: And so you were saying before that typically women are 412 00:23:53,600 --> 00:23:55,480 Speaker 2: more empathetic than men. 413 00:23:56,000 --> 00:23:57,320 Speaker 3: More sensitive to oxytocin. 414 00:23:57,640 --> 00:24:00,520 Speaker 2: Yes, do you think there's a you know, there's a 415 00:24:00,560 --> 00:24:03,919 Speaker 2: testosterone link to that, Like the more testosterone we have, 416 00:24:04,000 --> 00:24:05,359 Speaker 2: the less empathetic we are. 417 00:24:05,320 --> 00:24:05,880 Speaker 1: Or vice versa. 418 00:24:06,000 --> 00:24:09,640 Speaker 3: Yes, yeah, yeah, so testosterone interferes with the action of oxytocin, 419 00:24:09,720 --> 00:24:16,480 Speaker 3: So testosterone impairs oxytocin. Now, there's probably pretty good evolutionary 420 00:24:16,480 --> 00:24:20,800 Speaker 3: reasons for this the reason why women invented men in 421 00:24:20,800 --> 00:24:25,840 Speaker 3: the first place, you know, I mean, the Bible kind 422 00:24:25,840 --> 00:24:30,040 Speaker 3: of got it wrong because from a biological perspective, the 423 00:24:30,080 --> 00:24:34,600 Speaker 3: human race were female, and then they created a subset 424 00:24:35,080 --> 00:24:38,960 Speaker 3: from an evolutionary perspective which was designed to be dispensable 425 00:24:39,600 --> 00:24:42,760 Speaker 3: and more rugged and hard wearing, dispensable because it doesn't 426 00:24:42,760 --> 00:24:46,480 Speaker 3: actually carry the children. So you know, you can have 427 00:24:46,520 --> 00:24:48,480 Speaker 3: as many males as you like, it doesn't you know, 428 00:24:49,040 --> 00:24:51,680 Speaker 3: it's irrelevant the important ones, the ones carrying the children. 429 00:24:52,359 --> 00:24:55,840 Speaker 2: Do you look at t smiling like aier cap. 430 00:24:56,920 --> 00:25:02,159 Speaker 1: This is a favorite part of any podcast. Ever, Well, no, 431 00:25:02,240 --> 00:25:03,040 Speaker 1: it's by design. 432 00:25:03,280 --> 00:25:05,439 Speaker 3: You make the four wheel drive version, you're going to 433 00:25:05,480 --> 00:25:08,040 Speaker 3: lose a few, but they're therefore doing the rugged stuff, 434 00:25:09,359 --> 00:25:11,840 Speaker 3: you know, and it doesn't affect the ability to reproduce 435 00:25:11,880 --> 00:25:14,600 Speaker 3: because you only really need one that's capable of reproduction 436 00:25:15,480 --> 00:25:19,879 Speaker 3: and it's all good. So you know, that is the 437 00:25:19,880 --> 00:25:23,560 Speaker 3: biological history of males, so disappointing as it is. Where 438 00:25:23,640 --> 00:25:28,000 Speaker 3: the four wheel drive off road version of females that 439 00:25:28,040 --> 00:25:30,520 Speaker 3: they created to do the stuff that didn't matter if 440 00:25:30,520 --> 00:25:34,680 Speaker 3: you lost a few. And part of that, yeah, and 441 00:25:34,920 --> 00:25:37,920 Speaker 3: part of that, which is of course why male injury 442 00:25:38,359 --> 00:25:40,520 Speaker 3: and death rates are much much higher than female ones 443 00:25:40,560 --> 00:25:44,439 Speaker 3: because part of testosterone's action is that we have lower 444 00:25:44,560 --> 00:25:48,320 Speaker 3: impulse control, which means we're more likely to do dangerous 445 00:25:48,359 --> 00:25:51,520 Speaker 3: things than a female is. And one of the things 446 00:25:51,520 --> 00:25:55,119 Speaker 3: it interferes with is the reception of oxytocin, which is 447 00:25:55,400 --> 00:25:58,760 Speaker 3: the communal feeling between humans, which is that we are 448 00:25:58,800 --> 00:26:01,720 Speaker 3: concerned about what others think and the welfare of others. 449 00:26:02,480 --> 00:26:05,159 Speaker 3: And if you don't, it's also a good idea to 450 00:26:05,160 --> 00:26:07,240 Speaker 3: turn that down a bit if you're expecting people to 451 00:26:07,280 --> 00:26:08,720 Speaker 3: go out and risk their lives for you. 452 00:26:09,720 --> 00:26:13,840 Speaker 1: Yeah, wow, so bloody interesting. 453 00:26:14,240 --> 00:26:16,960 Speaker 3: Kind of went off topic there a bit, but yeah, 454 00:26:17,000 --> 00:26:18,840 Speaker 3: the history of males for you. 455 00:26:19,560 --> 00:26:20,680 Speaker 1: Yeah, no, I love it. 456 00:26:20,800 --> 00:26:23,920 Speaker 2: So the article on Substack by David is called the 457 00:26:23,960 --> 00:26:30,040 Speaker 2: empathy Pill paracetamol paracetamol surprising side effect? Is there any 458 00:26:30,480 --> 00:26:32,080 Speaker 2: Is there a little bow you want to put on 459 00:26:32,119 --> 00:26:32,720 Speaker 2: that at the end. 460 00:26:34,600 --> 00:26:38,399 Speaker 3: I think it's important to know these things, particularly in 461 00:26:39,440 --> 00:26:42,160 Speaker 3: I mean, I think this is the second highest drug 462 00:26:42,200 --> 00:26:46,679 Speaker 3: on the PBS. So the Australians spend vast amounts of 463 00:26:46,720 --> 00:26:50,399 Speaker 3: money on this drug every year and a lot of 464 00:26:50,480 --> 00:26:54,720 Speaker 3: us are taking a lot of it and it's important 465 00:26:54,760 --> 00:26:57,960 Speaker 3: to know. Hey, a side effect of this thing is 466 00:26:58,000 --> 00:27:01,000 Speaker 3: that you care less about those around you while you're 467 00:27:01,000 --> 00:27:01,320 Speaker 3: on it. 468 00:27:03,320 --> 00:27:06,280 Speaker 1: Oh dear, that's a good thing. I don't take it. 469 00:27:06,359 --> 00:27:10,800 Speaker 1: I already don't care. That's not true, is it, Tiff, 470 00:27:11,080 --> 00:27:15,560 Speaker 1: That's not true. I'm a big softy. 471 00:27:13,400 --> 00:27:13,600 Speaker 4: Yeah. 472 00:27:15,880 --> 00:27:19,159 Speaker 3: Just always check if he's taken some parasnamoor before you 473 00:27:19,240 --> 00:27:25,240 Speaker 3: ask him for a pay, right, Yeah, just just gonna 474 00:27:25,240 --> 00:27:26,919 Speaker 3: have a chat. But I just want to check have 475 00:27:27,000 --> 00:27:29,280 Speaker 3: you taken any parasitamile in the last hour or so. 476 00:27:29,760 --> 00:27:35,920 Speaker 2: It's save everybody some time and just don't ask. So mate, 477 00:27:35,960 --> 00:27:38,359 Speaker 2: we appreciate what say. Goodbye fair but as always we 478 00:27:38,520 --> 00:27:41,560 Speaker 2: appreciate you. Thanks for coming to hang out, you 479 00:27:41,600 --> 00:27:44,679 Speaker 1: Know, pleasure Jack, Thanks buddy, see ya.